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Conserved domains on  [gi|1571068627|gb|QBB69751|]
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sugar MFS transporter [Pseudolysobacter antarcticus]

Protein Classification

sugar MFS transporter( domain architecture ID 13024430)

sugar major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of sugar substrates including glucose, galactose, mannose and fucose

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_FucP_like cd17394
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ...
 17-420 3.46e-116

Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340952 [Multi-domain]  Cd Length: 401  Bit Score: 345.75  E-value: 3.46e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627  17 IAIIGGLFFIFGFVTWLNGPLITFVKLAFNLDDVNAFLVPMAFYLSYFFLALPSSWILKRTGMKRGMALGLFVMAIGAAV 96
Cdd:cd17394     1 LALVTSLFFLWGFATNLNDILIPQFKNIFDLSNFQASLVQFAFFGAYFIMAIPAGMLIKRYGYKKGILLGLGLYAIGALL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627  97 FGQFATMRIFPGALTGLFVIGAGLSLLQTASNPYISILGPIDSAAQRIAVMGICNKVAGILAPLVINALVLRGIGDLASK 176
Cdd:cd17394    81 FIPAASLRTYGLFLIALFVLASGLALLQTAANPYVTVLGPEETAARRLNLAQAFNSLGSTIAPLFGSYLILSGIPSTATA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 177 VESADVAGKTALSDEFAAKIHMPYMLMAGVLVLLAIWVMRSPLPEISASAANvaptSLSGKNEKSSIFHFAHLWLGVLCL 256
Cdd:cd17394   161 LAAMSAAELQAYKTAELASVQLPYLGIALVLLLLAVLILLSKLPEIEAAEAE----ALGSKGTLLRLLKNPHLRLGVLAI 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 257 FLYVGVEVMAGDAIGTYGQSFH--LPLDQTTFFTSFTLTAMLVGYLVGLVAIPRFvSQERYLAISAVLGVLFSIGAYLTQ 334
Cdd:cd17394   237 FFYVGAEVAIWSFLINYLMEYIagLTETSAATFVSYYWGGFMVGRFLGTALLKKI-SPKKLLAVFALLGLLLLLGAIFTG 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 335 GYISVGFVAALGFANAMMWPAIFPLAIRGLGRFTEFGSALLIMGISGGAIVPQLFAHLKQHHDFQAVFLILMVPCYLYIL 414
Cdd:cd17394   316 GMVALYALVLVGFFNSIMFPTIFSLALKGLGKHTKTGSGLLVMAIVGGAVVPLIQGAVADDAAGLRIAFLVPLLCFAYIL 395


                  ....*.
gi 1571068627 415 FYAVKG 420
Cdd:cd17394   396 FYGLRG 401
 
Name Accession Description Interval E-value
MFS_FucP_like cd17394
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ...
 17-420 3.46e-116

Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340952 [Multi-domain]  Cd Length: 401  Bit Score: 345.75  E-value: 3.46e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627  17 IAIIGGLFFIFGFVTWLNGPLITFVKLAFNLDDVNAFLVPMAFYLSYFFLALPSSWILKRTGMKRGMALGLFVMAIGAAV 96
Cdd:cd17394     1 LALVTSLFFLWGFATNLNDILIPQFKNIFDLSNFQASLVQFAFFGAYFIMAIPAGMLIKRYGYKKGILLGLGLYAIGALL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627  97 FGQFATMRIFPGALTGLFVIGAGLSLLQTASNPYISILGPIDSAAQRIAVMGICNKVAGILAPLVINALVLRGIGDLASK 176
Cdd:cd17394    81 FIPAASLRTYGLFLIALFVLASGLALLQTAANPYVTVLGPEETAARRLNLAQAFNSLGSTIAPLFGSYLILSGIPSTATA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 177 VESADVAGKTALSDEFAAKIHMPYMLMAGVLVLLAIWVMRSPLPEISASAANvaptSLSGKNEKSSIFHFAHLWLGVLCL 256
Cdd:cd17394   161 LAAMSAAELQAYKTAELASVQLPYLGIALVLLLLAVLILLSKLPEIEAAEAE----ALGSKGTLLRLLKNPHLRLGVLAI 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 257 FLYVGVEVMAGDAIGTYGQSFH--LPLDQTTFFTSFTLTAMLVGYLVGLVAIPRFvSQERYLAISAVLGVLFSIGAYLTQ 334
Cdd:cd17394   237 FFYVGAEVAIWSFLINYLMEYIagLTETSAATFVSYYWGGFMVGRFLGTALLKKI-SPKKLLAVFALLGLLLLLGAIFTG 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 335 GYISVGFVAALGFANAMMWPAIFPLAIRGLGRFTEFGSALLIMGISGGAIVPQLFAHLKQHHDFQAVFLILMVPCYLYIL 414
Cdd:cd17394   316 GMVALYALVLVGFFNSIMFPTIFSLALKGLGKHTKTGSGLLVMAIVGGAVVPLIQGAVADDAAGLRIAFLVPLLCFAYIL 395


                  ....*.
gi 1571068627 415 FYAVKG 420
Cdd:cd17394   396 FYGLRG 401
gluP TIGR01272
glucose/galactose transporter; This model describes the glucose/galactose transporter in ...
 97-416 9.44e-96

glucose/galactose transporter; This model describes the glucose/galactose transporter in bacteria. This belongs to the larger facilitator superfamily. Disruption of the loci leads to the total loss of glucose or galactose uptake in E.coli. Putative transporters in other bacterial species were isolated by functional complementation, which restored it functional activity. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273531 [Multi-domain]  Cd Length: 310  Bit Score: 290.26  E-value: 9.44e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627  97 FGQFATMRIFPGALTGLFVIGAGLSLLQTASNPYISILGPIDSAAQRIAVMGICNKVAGILAPLVINALVLRGIGDLASK 176
Cdd:TIGR01272   1 FGPAASQRYYVLFLGALFVLASGLTILQVAANPYVSILGPIETAASRLALTQAFNKLGTTVAPLFGGSLILSGAGDLSMQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 177 VESADVagktalsdeFAAKIHMPYMLMAGVLVLLAIWVMRSPLPEISAsaANVAPTSLSGKNEKSSIFHFAHLWLGVLCL 256
Cdd:TIGR01272  81 VATANA---------EAAKVHTPYLLLAGALAVLAIIFAFLPLPELQE--ADVARVSSGDTTQKTSAFQFTHLVLGALGI 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 257 FLYVGVEVMAGDAIGTYGQSFH---LPLDQTTFFTSFTLTAMLVGYLVGLVAIPrFVSQERYLAISAVLGVLFSIGAYLT 333
Cdd:TIGR01272 150 FVYVGAEVSAGSFLVNFLSDPHalgLPEDQAAHFTAYTWGGAMVGRFIGSAVMP-MISQGRYLAFNAFLAVLLSIGAALT 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 334 QGYISVGFVAALGFANAMMWPAIFPLAIRGLGRFTEFGSALLIMGISGGAIVPQLFAHLKQHHDFQAVFlILMVPCYLYI 413
Cdd:TIGR01272 229 HGYVAMWFVLALGLFNSIMFPTIFSLALNALGRHTSQGSGILCLAIVGGAIVPLLQGSLADCLGIQLAF-ALPVPCYLYI 307


                  ...
gi 1571068627 414 LFY 416
Cdd:TIGR01272 308 LFY 310
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
9-421 4.04e-72

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 232.05  E-value: 4.04e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627   9 PQRSHTSSIAIIGGLFFIFGFVTWLNGPLITFVKLAFNLDDVNAFLVPMAFYLSYFFLALPSSWILKRTGMKRGMALGLF 88
Cdd:COG0738     2 SKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627  89 VMAIGAAVfgqFATMRIFPGALTGLFVIGAGLSLLQTASNPYISILGPiDSAAQRIAVMGICNKVAGILAPLVINALVLR 168
Cdd:COG0738    82 LMALGLLL---FALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGP-ETAASRLNLLHAFFSLGALLGPLLGGLLILL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 169 GIGdlaskvesadvagktalsdefaAKIHMPYMLMAGVLVLLAIWVMRSPLPEISASAANVAPTSLSGKneksSIFHFAH 248
Cdd:COG0738   158 GLS----------------------LSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLK----SLLKNPR 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 249 LWLGVLCLFLYVGVEVMAGDAIGTYGQS-FHLPLDQTTFFTSFTLTAMLVGYLVGLVAIpRFVSQERYLAISAVLGVLFS 327
Cdd:COG0738   212 LLLGGLAIFLYVGAEGAIGDWLPLYLKDvLGLSEATAALGLSLFWGGMTIGRFLGGFLL-KRFGPVRLLRLSALLAAVGL 290

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 328 IGAYLTQG-YISVGFVAALGFANAMMWPAIFPLAIRGLGRFT-EFGSALLIMGISGGAIVPQLFAHLKQHHDFQAVFLIL 405
Cdd:COG0738   291 LLALLAPGpWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTaAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVP 370

                         410
                  ....*....|....*.
gi 1571068627 406 MVpCYLYILFYAVKGY 421
Cdd:COG0738   371 LV-CYLLILLLALALK 385
PRK10133 PRK10133
L-fucose:H+ symporter permease;
3-417 1.25e-34

L-fucose:H+ symporter permease;


Pssm-ID: 182260 [Multi-domain]  Cd Length: 438  Bit Score: 133.87  E-value: 1.25e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627   3 ITASDAPQ-RSHTSSIAIIGGLFFIFGFVTWLNGPLITFVKLAFNLDDVNAFLVPMAFYLSYFFLALPSSWILKRTGMKR 81
Cdd:PRK10133   13 AVDKDAGQsRSYIIPFALLCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKA 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627  82 GMALGLFVMAIGAAVFGQFATMRIFPGALTGLFVIGAGLSLLQTASNPYISILGPIDSAAQRIAVMGICNKVAGILAPLV 161
Cdd:PRK10133   93 GIITGLFLYALGAALFWPAAEIMNYTLFLVGLFIIAAGLGCLETAANPFVTVLGPESSGHFRLNLAQTFNSFGAIIAVVF 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 162 INALVLRGIGDLASKV-ESADVAGKTALSDEFAAKIHMPYMLMAGVLVLLAIWVMRSPLPEISASAANVAPTSlSGKNEK 240
Cdd:PRK10133  173 GQSLILSNVPHQSQDVlDKMTPEQLSAYKHSLVLSVQTPYMIIVAIVLLVALLIMLTKFPALQSDNHSDAKQG-SFSASL 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 241 SSIFHFAHLWLGVLCLFLYVGVEVMAGDAIGTYGQSfHLPLDQTTFFTSFTLTAML---VGYLVGLVAIPRFvSQERYLA 317
Cdd:PRK10133  252 SRLARIRHWRWAVLAQFCYVGAQTACWSYLIRYAVE-EIPGMTAGFAANYLTGTMVcffIGRFTGTWLISRF-APHKVLA 329

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 318 ISAVLGVLFSIGAYLTQGYISvgfVAALGFANAMM---WPAIFPLAIRGLGRFTEFGSALLIMGISGGAIVPQLFAHLKQ 394
Cdd:PRK10133  330 AYALIAMALCLISAFAGGHVG---LIALTLCSAFMsiqYPTIFSLGIKNLGQDTKYGSSFIVMTIIGGGIVTPVMGFVSD 406

                         410       420
                  ....*....|....*....|...
gi 1571068627 395 HHDFQAVFLILMVPCYLYILFYA 417
Cdd:PRK10133  407 AAGNIPTAELIPALCFAVIFIFA 429
MFS_1 pfam07690
Major Facilitator Superfamily;
23-159 1.76e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 43.56  E-value: 1.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627  23 LFFIFGFVTWLNGPLITFVKLAFNLDDVNAFLVPMAFYLSYFFLALPSSWILKRTGMKRGMALGLFVMAIGAAVFGQFAT 102
Cdd:pfam07690 208 ALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSL 287

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1571068627 103 MRIFPGALTGLFVIGAGLSLLQTASNPYISILGPIDSAAQRIAVMGICNKVAGILAP 159
Cdd:pfam07690 288 TLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
 
Name Accession Description Interval E-value
MFS_FucP_like cd17394
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ...
 17-420 3.46e-116

Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340952 [Multi-domain]  Cd Length: 401  Bit Score: 345.75  E-value: 3.46e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627  17 IAIIGGLFFIFGFVTWLNGPLITFVKLAFNLDDVNAFLVPMAFYLSYFFLALPSSWILKRTGMKRGMALGLFVMAIGAAV 96
Cdd:cd17394     1 LALVTSLFFLWGFATNLNDILIPQFKNIFDLSNFQASLVQFAFFGAYFIMAIPAGMLIKRYGYKKGILLGLGLYAIGALL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627  97 FGQFATMRIFPGALTGLFVIGAGLSLLQTASNPYISILGPIDSAAQRIAVMGICNKVAGILAPLVINALVLRGIGDLASK 176
Cdd:cd17394    81 FIPAASLRTYGLFLIALFVLASGLALLQTAANPYVTVLGPEETAARRLNLAQAFNSLGSTIAPLFGSYLILSGIPSTATA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 177 VESADVAGKTALSDEFAAKIHMPYMLMAGVLVLLAIWVMRSPLPEISASAANvaptSLSGKNEKSSIFHFAHLWLGVLCL 256
Cdd:cd17394   161 LAAMSAAELQAYKTAELASVQLPYLGIALVLLLLAVLILLSKLPEIEAAEAE----ALGSKGTLLRLLKNPHLRLGVLAI 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 257 FLYVGVEVMAGDAIGTYGQSFH--LPLDQTTFFTSFTLTAMLVGYLVGLVAIPRFvSQERYLAISAVLGVLFSIGAYLTQ 334
Cdd:cd17394   237 FFYVGAEVAIWSFLINYLMEYIagLTETSAATFVSYYWGGFMVGRFLGTALLKKI-SPKKLLAVFALLGLLLLLGAIFTG 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 335 GYISVGFVAALGFANAMMWPAIFPLAIRGLGRFTEFGSALLIMGISGGAIVPQLFAHLKQHHDFQAVFLILMVPCYLYIL 414
Cdd:cd17394   316 GMVALYALVLVGFFNSIMFPTIFSLALKGLGKHTKTGSGLLVMAIVGGAVVPLIQGAVADDAAGLRIAFLVPLLCFAYIL 395


                  ....*.
gi 1571068627 415 FYAVKG 420
Cdd:cd17394   396 FYGLRG 401
gluP TIGR01272
glucose/galactose transporter; This model describes the glucose/galactose transporter in ...
 97-416 9.44e-96

glucose/galactose transporter; This model describes the glucose/galactose transporter in bacteria. This belongs to the larger facilitator superfamily. Disruption of the loci leads to the total loss of glucose or galactose uptake in E.coli. Putative transporters in other bacterial species were isolated by functional complementation, which restored it functional activity. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273531 [Multi-domain]  Cd Length: 310  Bit Score: 290.26  E-value: 9.44e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627  97 FGQFATMRIFPGALTGLFVIGAGLSLLQTASNPYISILGPIDSAAQRIAVMGICNKVAGILAPLVINALVLRGIGDLASK 176
Cdd:TIGR01272   1 FGPAASQRYYVLFLGALFVLASGLTILQVAANPYVSILGPIETAASRLALTQAFNKLGTTVAPLFGGSLILSGAGDLSMQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 177 VESADVagktalsdeFAAKIHMPYMLMAGVLVLLAIWVMRSPLPEISAsaANVAPTSLSGKNEKSSIFHFAHLWLGVLCL 256
Cdd:TIGR01272  81 VATANA---------EAAKVHTPYLLLAGALAVLAIIFAFLPLPELQE--ADVARVSSGDTTQKTSAFQFTHLVLGALGI 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 257 FLYVGVEVMAGDAIGTYGQSFH---LPLDQTTFFTSFTLTAMLVGYLVGLVAIPrFVSQERYLAISAVLGVLFSIGAYLT 333
Cdd:TIGR01272 150 FVYVGAEVSAGSFLVNFLSDPHalgLPEDQAAHFTAYTWGGAMVGRFIGSAVMP-MISQGRYLAFNAFLAVLLSIGAALT 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 334 QGYISVGFVAALGFANAMMWPAIFPLAIRGLGRFTEFGSALLIMGISGGAIVPQLFAHLKQHHDFQAVFlILMVPCYLYI 413
Cdd:TIGR01272 229 HGYVAMWFVLALGLFNSIMFPTIFSLALNALGRHTSQGSGILCLAIVGGAIVPLLQGSLADCLGIQLAF-ALPVPCYLYI 307


                  ...
gi 1571068627 414 LFY 416
Cdd:TIGR01272 308 LFY 310
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
9-421 4.04e-72

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 232.05  E-value: 4.04e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627   9 PQRSHTSSIAIIGGLFFIFGFVTWLNGPLITFVKLAFNLDDVNAFLVPMAFYLSYFFLALPSSWILKRTGMKRGMALGLF 88
Cdd:COG0738     2 SKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627  89 VMAIGAAVfgqFATMRIFPGALTGLFVIGAGLSLLQTASNPYISILGPiDSAAQRIAVMGICNKVAGILAPLVINALVLR 168
Cdd:COG0738    82 LMALGLLL---FALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGP-ETAASRLNLLHAFFSLGALLGPLLGGLLILL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 169 GIGdlaskvesadvagktalsdefaAKIHMPYMLMAGVLVLLAIWVMRSPLPEISASAANVAPTSLSGKneksSIFHFAH 248
Cdd:COG0738   158 GLS----------------------LSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLK----SLLKNPR 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 249 LWLGVLCLFLYVGVEVMAGDAIGTYGQS-FHLPLDQTTFFTSFTLTAMLVGYLVGLVAIpRFVSQERYLAISAVLGVLFS 327
Cdd:COG0738   212 LLLGGLAIFLYVGAEGAIGDWLPLYLKDvLGLSEATAALGLSLFWGGMTIGRFLGGFLL-KRFGPVRLLRLSALLAAVGL 290

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 328 IGAYLTQG-YISVGFVAALGFANAMMWPAIFPLAIRGLGRFT-EFGSALLIMGISGGAIVPQLFAHLKQHHDFQAVFLIL 405
Cdd:COG0738   291 LLALLAPGpWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTaAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVP 370

                         410
                  ....*....|....*.
gi 1571068627 406 MVpCYLYILFYAVKGY 421
Cdd:COG0738   371 LV-CYLLILLLALALK 385
PRK10133 PRK10133
L-fucose:H+ symporter permease;
3-417 1.25e-34

L-fucose:H+ symporter permease;


Pssm-ID: 182260 [Multi-domain]  Cd Length: 438  Bit Score: 133.87  E-value: 1.25e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627   3 ITASDAPQ-RSHTSSIAIIGGLFFIFGFVTWLNGPLITFVKLAFNLDDVNAFLVPMAFYLSYFFLALPSSWILKRTGMKR 81
Cdd:PRK10133   13 AVDKDAGQsRSYIIPFALLCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKA 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627  82 GMALGLFVMAIGAAVFGQFATMRIFPGALTGLFVIGAGLSLLQTASNPYISILGPIDSAAQRIAVMGICNKVAGILAPLV 161
Cdd:PRK10133   93 GIITGLFLYALGAALFWPAAEIMNYTLFLVGLFIIAAGLGCLETAANPFVTVLGPESSGHFRLNLAQTFNSFGAIIAVVF 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 162 INALVLRGIGDLASKV-ESADVAGKTALSDEFAAKIHMPYMLMAGVLVLLAIWVMRSPLPEISASAANVAPTSlSGKNEK 240
Cdd:PRK10133  173 GQSLILSNVPHQSQDVlDKMTPEQLSAYKHSLVLSVQTPYMIIVAIVLLVALLIMLTKFPALQSDNHSDAKQG-SFSASL 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 241 SSIFHFAHLWLGVLCLFLYVGVEVMAGDAIGTYGQSfHLPLDQTTFFTSFTLTAML---VGYLVGLVAIPRFvSQERYLA 317
Cdd:PRK10133  252 SRLARIRHWRWAVLAQFCYVGAQTACWSYLIRYAVE-EIPGMTAGFAANYLTGTMVcffIGRFTGTWLISRF-APHKVLA 329

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 318 ISAVLGVLFSIGAYLTQGYISvgfVAALGFANAMM---WPAIFPLAIRGLGRFTEFGSALLIMGISGGAIVPQLFAHLKQ 394
Cdd:PRK10133  330 AYALIAMALCLISAFAGGHVG---LIALTLCSAFMsiqYPTIFSLGIKNLGQDTKYGSSFIVMTIIGGGIVTPVMGFVSD 406

                         410       420
                  ....*....|....*....|...
gi 1571068627 395 HHDFQAVFLILMVPCYLYILFYA 417
Cdd:PRK10133  407 AAGNIPTAELIPALCFAVIFIFA 429
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 23-416 2.35e-15

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 76.98  E-value: 2.35e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627  23 LFFIFGFVTWLNGPLITFVKLAFNLDDVNAFLVPMAFYLSYFFLALPSSWILKRTGMKRGMALGLFVMAIGAAVFgqfAT 102
Cdd:cd17333     4 SFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALI---FA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 103 MRIFPGALTGLFVIGAGLSLLQTASNPYISILGPIDSAAqRIAVMGICNKVAGILAPLVINALVLRGIGdlaskvesadv 182
Cdd:cd17333    81 TPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSAT-RLNVLHGFFGLGALIGPLIATSLLTSELS----------- 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 183 agktalsdefaakIHMPYMLMAGVLVLLAIWVMRSPLPEiSASAANVAPTSLSGKNEKSSIFHFAHLWLGVLCLFLYVGV 262
Cdd:cd17333   149 -------------WSWAYLIIGLIYLLLAILILLTLFPE-LPSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGA 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 263 EVMAGDAIGTYGQ-SFHLPLDQTTFFTSFTLTAMLVGYLVGlVAIPRFVSQERYLAISAVLGVLFSIGAYLTQGYISVGF 341
Cdd:cd17333   215 ETAFSSWVPSYLVeKKHVSDGLAGYLLSGFWVGITIGRLLG-GPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLV 293

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1571068627 342 -VAALGFANAMMWPAIFPLAIRGLGRF-TEFGSALLIMGISGGAIVPQLFAHLKQHHDFQAVFLILMVPCYLYILFY 416
Cdd:cd17333   294 aTALLGLFMAALFPTILSLGISNLPYAkGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVLA 370
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
6-418 1.59e-10

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 62.19  E-value: 1.59e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627   6 SDAPQRSHTSSIAIIGGLFFIFGFVTWLNGPLITFVKLAFNLDDVNAFLVPMAFYLSYFFLALPSSWILKRTGMKRGMAL 85
Cdd:COG2271     1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627  86 GLFVMAIGAAVFGQFATmriFPGALTGLFVIGAGLSLLQTASNPYISILGPIDSAAQRIAVMGICNKVAGILAPLVINAL 165
Cdd:COG2271    81 GLLLWGLATLLFGFATS---FWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 166 VLrgigdlaskvesadvagktalsdefAAKIHMPYMLMAGVLVLLAIWVmrsplpeisasaanvaptslsgknekssifh 245
Cdd:COG2271   158 LA-------------------------AFGWRAAFLILGLPGLLLALLR------------------------------- 181

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 246 fahLWLGVLCLFLYVGVEVMAGDAIGTY-GQSFHLPLDQTTFFTSFTLTAMLVGYLVGLVAIPRFVSQERYLAI--SAVL 322
Cdd:COG2271   182 ---FWLLALAYFLVYFALYGFLTWLPTYlVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAigLLLA 258

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 323 GVLFSIGAYLTQGYISVGFVAALGFANAMMWPAIFPLAIRGLGRfTEFGSA---LLIMGISGGAIVPQLFAHLKQHHDFQ 399
Cdd:COG2271   259 ALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPK-KARGTAsglVNTFGFLGGALGPLLVGYLLDATGYQ 337

                         410
                  ....*....|....*....
gi 1571068627 400 AVFLILMVPCYLYILFYAV 418
Cdd:COG2271   338 AAFLLLAALALLAALLALL 356
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
8-362 2.61e-08

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 55.37  E-value: 2.61e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627   8 APQRSHTSSIAIIGGLFFIFGFVTWLNGPLITFVKLAFNLDDVNAFLVPMAFYLSYFFLALPSSWILKRTGMKRGMALGL 87
Cdd:COG2814     3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627  88 FVMAIGAAVFGQFATMRIFpgaLTGLFVIGAGLSLLQTASNPYISILGPIDSAAQRIAVMGICNKVAGILAPLVINALvl 167
Cdd:COG2814    83 LLFALGSLLCALAPSLWLL---LAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLL-- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 168 rgigdlaskvesADVAGKTALsdefaakihmpyMLMAGVLVLLAIWVMRSPLPEISASAANVAPTSLsgknekSSIFHFA 247
Cdd:COG2814   158 ------------ADLFGWRWV------------FLVNAVLALLALLLLLRLLPESRPAARARLRGSL------RELLRRP 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 248 HLWLGVLCLFLYVGVEVMAGDAIGTYGQS-FHLPLDQTTFFTSFTLTAMLVGYLVGLVAIPRFVSQERYLAISAVLGVLF 326
Cdd:COG2814   208 RLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGL 287

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1571068627 327 SIGAYLTQGYISVGFVAALGFANAMMWPAIFPLAIR 362
Cdd:COG2814   288 LLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAE 323
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 20-416 2.13e-07

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 52.81  E-value: 2.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627  20 IGGLFFIFGFVTWLNGPLITFVKLAFNLDDVNAFLVPMAFYLSYFFLALPSSWILKRTGMKRGMALGLFVMAIGAAVfgq 99
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALL--- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 100 FATMRIFPGALTGLFVIGAGLSLLQTASNPYISILGPIDSAAQRIAVMGICNKVAGILAPLVINALVLRGIGDLASkves 179
Cdd:cd06174    78 FAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRA---- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 180 advagktalsdefaakihMPYMLMAGVLVLLAIWVMRSPLPEISASAANVAPTSLSGKNEKSSIFHFAHLWLGVLCLFLY 259
Cdd:cd06174   154 ------------------VFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLV 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 260 VGVEVMAGDAIGTYG-QSFHLPLDQTTFFTSFTLTAMLVGYLVGLVAIPRFVSQERYLAISAVLGVLFSIGAYL-TQGYI 337
Cdd:cd06174   216 NLAYYSFSTLLPLFLlDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLaPSLLL 295

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 338 SVGFVAALGFANAMMWPAIFPLA--IRGLGRFTEFGSALLIMGISGGAIVPQLFAHL-KQHHDFQAVFLILMVPCYLYIL 414
Cdd:cd06174   296 LLLLLLLLGFGLGGLLPLSFALIaeLFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLlAATFGLTGAFLVLAVLLLLAAI 375


                  ..
gi 1571068627 415 FY 416
Cdd:cd06174   376 LL 377
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
1-407 1.45e-06

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 50.26  E-value: 1.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627   1 MSITASDAPQRSHTSSIAIIGGLFFI---FGFVTWLNGPLITFVKLAFNLDDVNAFLVPMAFYLSYFFLALPSSWILKRT 77
Cdd:COG2807     1 MSTTSSSARRSRRAGRWLLLLAIVLValnLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627  78 GMKRGMALGLFVMAIGAAVFGQFATmriFPGALTGLFVIGAGLSLLQTASNPYISILGPiDSAAQRIAVMGICNKVAGIL 157
Cdd:COG2807    81 GLERTLLLALLLLAAGLLLRSLAPS---VALLLAGTALIGAGIAVGNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAAL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 158 APLVinalvlrgigdlaskveSADVAGKTALSDEFAAkihmpYMLMAGVLVLLAIWVMRSPLPEISASAANVAPTSLsgk 237
Cdd:COG2807   157 AAGL-----------------TVPLAAALGWRGALAV-----WALLALLALLLWLPLLRRRPAAAAAAPAAASLRSL--- 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 238 nekssiFHFAHLWLGVLCLFLYVGVEVMAGDAIGTYGQSFHLPLDQTTFFTSFTLTAMLVGYLVGLVAIPRFVSQERYLA 317
Cdd:COG2807   212 ------WRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLL 285

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 318 ISAVLGVLFSIGAYLTQGYISVGFVAALGFANAMMWPAIFPLAIRGLGRFTEFGSALLIM---GISGGAIVPQLFAHLKQ 394
Cdd:COG2807   286 LLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAALSGMAqsvGYLLAALGPLLVGALHD 365

                         410
                  ....*....|....
gi 1571068627 395 H-HDFQAVFLILMV 407
Cdd:COG2807   366 AtGSWTAALLLLAA 379
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 12-218 1.70e-06

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 49.86  E-value: 1.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627  12 SHTSSIAIIGGLFFIFGFVTwLNGPLITFVKLAFNLDDVNAFLVPMAFYLSYFFLALPSSWILKRTGMKRGMALGLFVMA 91
Cdd:cd17321   167 ARTFSGAVLAAFLLGAALGG-LLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTA 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627  92 IGAAVFGQFATMRIFPGALTGLFVIGAGLSLLQTASNPYISILGPIDSAAQRIAVMGICNKVAGILAPLVINALVLRGIG 171
Cdd:cd17321   246 VGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAGLS 325

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1571068627 172 DLASkvESADVAGKTALSDEFAAKIHMPYMLMAGVLVLLAIWVMRSP 218
Cdd:cd17321   326 ANLG--DSGVAALLSAAAAAFAAGFHLAFLVAAALALLAALLALLLP 370
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
17-216 4.27e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 48.74  E-value: 4.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627  17 IAIIGGLFFIFGFVTWLNGPLITFVKLAFNLDDVNAFLVPMAFYLSYFFLALPSSWILKRTGMKRGMALGLFVMAIGAAV 96
Cdd:COG2211   231 LLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLL 310

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627  97 FGqFATMRIFPGALTGLFVIGAGLSLLQTASNPYISILGPIDSAAQRI-------AVMGICNKVAGILAPLVInALVLRG 169
Cdd:COG2211   311 LF-FLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRrreglyfGIFTFAIKLGQALAGALA-GLLLAL 388

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1571068627 170 IGDLASkvesadvagkTALSDEFAAKIHMPYMLMAGVLVLLAIWVMR 216
Cdd:COG2211   389 FGYVAG----------AAQSPSALTGIRLLFFLLPAVLLLLAALLLL 425
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
17-407 8.84e-06

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 47.57  E-value: 8.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627  17 IAIIGGLFFIFGFVTW-LNGPLITFVKLAFNLDDVNAFLVPMAFYLSYFFLALPSSWILKRTGMKRGMALGLFVMAIGAA 95
Cdd:COG2223     6 VLLLATLAFFLAFGVWyLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627  96 VFGQFATmriFPGALTGLFVIGAGLSLLQTASNPYISILGPidsAAQRIAVMGIcNKVAGILAPLVINALVLRGIGDLAs 175
Cdd:COG2223    86 LLALAVS---YWLLLLLGLLLGIGGGGSFAVGIALVSKWFP---PDRRGLALGL-AAGGGNLGAAVAAFLAPLLIAAFG- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 176 kvesadvagktalsdefaakIHMPYMLMAGVLVLLAIWVMRSpLPEISASAANVAPTSLSGKNEkssIFHFAHLWLGVLC 255
Cdd:COG2223   158 --------------------WRNAFLILGILLLVVAVLAWLF-LRDPPAGAAAAAKASLRDQLE---ALRDPRFWLLSLL 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 256 LFLYVGVEVMAGDAIGTYGQS-FHLPLDQTTFFTSFTLTAMLVGYLVGLVAIPRFVSQERYLAISAVLGVLFSIGAYLTQ 334
Cdd:COG2223   214 YFGTFGSFIGFSSWLPPYLVDqFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALG 293

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1571068627 335 GYISVGFVAALGFANAMMWPAIFPLAIRGLGRFTEFGSA---LLIMGISGGAIVPQLFAHLKQH-HDFQAVFLILMV 407
Cdd:COG2223   294 SLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVyglVGAAGGLGGFLGPLLFGALLDAtGSYTAAFLVFAV 370
MFS_1 pfam07690
Major Facilitator Superfamily;
23-159 1.76e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 43.56  E-value: 1.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627  23 LFFIFGFVTWLNGPLITFVKLAFNLDDVNAFLVPMAFYLSYFFLALPSSWILKRTGMKRGMALGLFVMAIGAAVFGQFAT 102
Cdd:pfam07690 208 ALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSL 287

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1571068627 103 MRIFPGALTGLFVIGAGLSLLQTASNPYISILGPIDSAAQRIAVMGICNKVAGILAP 159
Cdd:pfam07690 288 TLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_1 pfam07690
Major Facilitator Superfamily;
19-366 3.26e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 42.79  E-value: 3.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627  19 IIGGLFFIFGFVTWLNGPLITFVKLAFNLDDVNAFLVPMAFYLSYFFLALPSSWILKRTGMKRGMALGLFVMAIGAAVFG 98
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627  99 QFATMRIFpgaLTGLFVIGAGLSLLQTASNPYISILGPIDSAAQRIAVMGICNKVAGILAPLVINALVLRGIgdlaskve 178
Cdd:pfam07690  81 FASSLWLL---LVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-------- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 179 sadvagktalsdefaakIHMPYMLMAGVLVLLAIWVMRSPLPEISASAANVAPTSLSGKNEKSSIFHFAHLWLgVLCLFL 258
Cdd:pfam07690 150 -----------------WRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWL-LLALLL 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571068627 259 YVGVEVMAGDAIGTYGQSFHLPLDQTTFFTSFTLTAMLVGYLVGLVAIPRFVSQERYL---AISAVLGVLFSIGAYLTQG 335
Cdd:pfam07690 212 FGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLlalLLLILAALGLLLLSLTLSS 291

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1571068627 336 YISVGFVAALGFANAMMWPAIFPLAIRGLGR 366
Cdd:pfam07690 292 LWLLLALLLLGFGFGLVFPALNALVSDLAPK 322
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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