NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1570883856|gb|RYT85838|]
View 

acetate kinase [Bifidobacterium animalis]

Protein Classification

acetate/propionate family kinase( domain architecture ID 10000961)

acetate/propionate family kinase such as acetate kinase that catalyzes the production of acetyl-CoA by phosphorylating acetate in the presence of ATP; may act on propionate and/or other substrates as well

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
AckA COG0282
Acetate kinase [Energy production and conversion];
3-399 0e+00

Acetate kinase [Energy production and conversion];


:

Pssm-ID: 440051  Cd Length: 395  Bit Score: 581.61  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856   3 KTVLVINSGSSSIKYQLVDLESGEGIASGIVEKIGEPiDGHYKYEY-NGEKHELDEKVENHEQGLKRVLGFFEEYGPSLE 81
Cdd:COG0282     1 MKILVLNAGSSSLKFQLFDMDSEEVLAKGLVERIGLP-GARLKHKDaGGEKVERELPIPDHAAALALVLELLTDHGIIKD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856  82 ETGIIAVGHRVVQGGDTFPNPALVTPDTTAKVEELAVLAPLHNGPEAKGARVMRELLPEIPQVYVFDSSFFQQLPKASST 161
Cdd:COG0282    80 LDEIDAVGHRVVHGGEKFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQTMPEVAYL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 162 YALNKEVADKYKIKRYGAHGTSHWFVSSQIPEFLGIDAEAakgLKQIVLHIGNGASASAELGGRPIETSMGLTPLEGLVM 241
Cdd:COG0282   160 YALPYELYEKYGIRRYGFHGTSHRYVAERAAELLGKPLAD---LRLITAHLGNGASLCAIKNGKSVDTSMGFTPLEGLVM 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 242 GSRTGDIDPAAVFHLMRNADMNVDELDDLFNKKSGMMGMTGF-GDMREVHRLVAEGDENAKLALDIYVHRIVSYIGAYTA 320
Cdd:COG0282   237 GTRSGDIDPGVVLYLMRKEGLSADEVDDLLNKESGLLGLSGIsSDMRDLEEAAASGDERARLALDMFVYRIKKYIGAYAA 316

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1570883856 321 QLGGLDVLTFTAGVGENDEIVRRMVCEKLAPFGVKLDNDKNDTRSKEpRIISTPDSTVTVVVYPTNEELAIAQRANEIV 399
Cdd:COG0282   317 ALGGLDALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANAARGGE-RVISTPDSRVKVLVIPTNEELMIARDTLRLL 394
 
Name Accession Description Interval E-value
AckA COG0282
Acetate kinase [Energy production and conversion];
3-399 0e+00

Acetate kinase [Energy production and conversion];


Pssm-ID: 440051  Cd Length: 395  Bit Score: 581.61  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856   3 KTVLVINSGSSSIKYQLVDLESGEGIASGIVEKIGEPiDGHYKYEY-NGEKHELDEKVENHEQGLKRVLGFFEEYGPSLE 81
Cdd:COG0282     1 MKILVLNAGSSSLKFQLFDMDSEEVLAKGLVERIGLP-GARLKHKDaGGEKVERELPIPDHAAALALVLELLTDHGIIKD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856  82 ETGIIAVGHRVVQGGDTFPNPALVTPDTTAKVEELAVLAPLHNGPEAKGARVMRELLPEIPQVYVFDSSFFQQLPKASST 161
Cdd:COG0282    80 LDEIDAVGHRVVHGGEKFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQTMPEVAYL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 162 YALNKEVADKYKIKRYGAHGTSHWFVSSQIPEFLGIDAEAakgLKQIVLHIGNGASASAELGGRPIETSMGLTPLEGLVM 241
Cdd:COG0282   160 YALPYELYEKYGIRRYGFHGTSHRYVAERAAELLGKPLAD---LRLITAHLGNGASLCAIKNGKSVDTSMGFTPLEGLVM 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 242 GSRTGDIDPAAVFHLMRNADMNVDELDDLFNKKSGMMGMTGF-GDMREVHRLVAEGDENAKLALDIYVHRIVSYIGAYTA 320
Cdd:COG0282   237 GTRSGDIDPGVVLYLMRKEGLSADEVDDLLNKESGLLGLSGIsSDMRDLEEAAASGDERARLALDMFVYRIKKYIGAYAA 316

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1570883856 321 QLGGLDVLTFTAGVGENDEIVRRMVCEKLAPFGVKLDNDKNDTRSKEpRIISTPDSTVTVVVYPTNEELAIAQRANEIV 399
Cdd:COG0282   317 ALGGLDALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANAARGGE-RVISTPDSRVKVLVIPTNEELMIARDTLRLL 394
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 3-399 0e+00

acetate kinase A/propionate kinase 2; Reviewed


Pssm-ID: 234680  Cd Length: 402  Bit Score: 557.03  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856   3 KTVLVINSGSSSIKYQLVDLESGEGIASGIVEKIGEPiDGHYKYEYNGEKHELDEK-VENHEQGLKRVLGFF--EEYGPS 79
Cdd:PRK00180    1 MKILVLNAGSSSLKFQLIDMPNEEVLASGLVERIGLP-DSRIKIKVDGGEKEEEELpIPDHAEALKFLLNTLtdGKLGLI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856  80 LEETGIIAVGHRVVQGGDTFPNPALVTPDTTAKVEELAVLAPLHNGPEAKGARVMRELLPEIPQVYVFDSSFFQQLPKAS 159
Cdd:PRK00180   80 KDLDEITAVGHRVVHGGEKFTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNVPQVAVFDTAFHQTMPEEA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 160 STYALNKEVADKYKIKRYGAHGTSHWFVSSQIPEFLGIDAEaakGLKQIVLHIGNGASASAELGGRPIETSMGLTPLEGL 239
Cdd:PRK00180  160 YLYALPYELYEKYGIRRYGFHGTSHRYVSQRAAELLGKPLE---ELNLITCHLGNGASIAAIKNGKSVDTSMGFTPLEGL 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 240 VMGSRTGDIDPAAVFHLMRNADMNVDELDDLFNKKSGMMGMTGFG-DMREVHRLVAEGDENAKLALDIYVHRIVSYIGAY 318
Cdd:PRK00180  237 VMGTRSGDIDPAIIPYLMEKLGMSVDEIDNLLNKKSGLLGLSGVSsDMRDIEAAAEEGDERAKLALDVFVYRLAKYIGSY 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 319 TAQL-GGLDVLTFTAGVGENDEIVRRMVCEKLAPFGVKLDNDKNDT-RSKEPRIISTPDSTVTVVVYPTNEELAIAQRAN 396
Cdd:PRK00180  317 AAALnGRLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNLAaRFGKEGDISTPDSKVKVLVIPTNEELMIARDTL 396


                  ...
gi 1570883856 397 EIV 399
Cdd:PRK00180  397 RLL 399
ASKHA_NBD_AcK_PK cd24010
nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain ...
 5-393 0e+00

nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain family; The family corresponds to a group of proteins which transfer phosphate from ATP to a short chain aliphatic acid. It includes acetate kinase (AckA) and propionate kinase (TdcD and PduW). Acetate kinase (EC 2.7.2.1), also called acetokinase, catalyzes the formation of acetyl phosphate from acetate and ATP. It can also catalyze the reverse reaction in the presence of a divalent cation. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically. Propionate kinase TdcD (EC 2.7.2.15) catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor. The family also includes propionate kinase PduW (EC 2.7.2.15) that works with phosphate acetyltransferase (pta) to capture exogenous propionate and regenerate propionyl-CoA during degradation of propionate and 1,2-propanediol (1,2-PD). This protein restores growth to an eutQ deletion on ethanolamine and tetrathionate under anoxic conditions. The AcK/PK family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466860  Cd Length: 392  Bit Score: 531.70  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856   5 VLVINSGSSSIKYQLVDLESGEGIASGIVEKIGEPiDGHYKYEY-NGEKHELDEKVENHEQGLKRVLGFFEEYGPSLEET 83
Cdd:cd24010     1 ILVINCGSSSLKFQLFDMPTEEVLASGLVERIGLE-GARLKHKVnNGEKIKEELPIPDHEEALKAILDTLTDPELGVSLD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856  84 GIIAVGHRVVQGGDTFPNPALVTPDTTAKVEELAVLAPLHNGPEAKGARVMRELLPEIPQVYVFDSSFFQQLPKASSTYA 163
Cdd:cd24010    80 EIDAVGHRVVHGGEKFTESVLIDDEVIAAIEDLSPLAPLHNPANLAGIEAARKLLPDVPQVAVFDTAFHQTMPPHAYLYA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 164 LNKEVADKYKIKRYGAHGTSHWFVSSQIPEFLGIDAEAakgLKQIVLHIGNGASASAELGGRPIETSMGLTPLEGLVMGS 243
Cdd:cd24010   160 LPYELYEKYGIRRYGFHGTSHRYVSRRAAELLGKPLED---LNLITCHLGNGASICAIKNGKSVDTSMGLTPLEGLVMGT 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 244 RTGDIDPAAVFHLMRNADMNVDELDDLFNKKSGMMGMTG-FGDMREVHRLVAEGDENAKLALDIYVHRIVSYIGAYTAQL 322
Cdd:cd24010   237 RSGDIDPAIVFYLMKKEGMSVDEIERLLNKKSGLLGISGvSSDMRDIEEAAEEGDERAKLALDVFVYRIKKYIGAYAAAL 316

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1570883856 323 GGLDVLTFTAGVGENDEIVRRMVCEKLAPFGVKLDNDKNDTRSKEPRIISTPDSTVTVVVYPTNEELAIAQ 393
Cdd:cd24010   317 GGVDAIVFTGGIGENSALIRELVCEGLEFLGIELDEEKNKAAGGGEREISTPDSKVKVLVIPTNEELMIAR 387
Acetate_kinase pfam00871
Acetokinase family; This family includes acetate kinase, butyrate kinase and ...
 5-393 2.56e-148

Acetokinase family; This family includes acetate kinase, butyrate kinase and 2-methylpropanoate kinase.


Pssm-ID: 395700  Cd Length: 387  Bit Score: 426.07  E-value: 2.56e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856   5 VLVINSGSSSIKYQLVDLESGEGIASGIVEKIGEPIDGHYKYEYNGEKHELDEKVENHEQGLKRVLGFFEEYGPSLEETG 84
Cdd:pfam00871   2 VLVLNAGSSSIKFQLFDAVIGEVLLSGLAERIGLPNARILWKMNGGKKNAALLAGADHSEALNFILNTLLKHKIIELLAE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856  85 IIAVGHRVVQGGDTFPNPALVTPDTTAKVEELAVLAPLHNGPEAKGARVMRELLPEIPQVYVFDSSFFQQLPKASSTYAL 164
Cdd:pfam00871  82 ITLIGHRVVHGGEKFTESVLITDEVIQGIKDLIPLAPLHNPAHLDGIEEAFKLFPQVKNVAVFDTAFHQTMPEEAYLYAL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 165 NKEVADKYKIKRYGAHGTSHWFVSSQIPEFLGidaEAAKGLKQIVLHIGNGASASAELGGRPIETSMGLTPLEGLVMGSR 244
Cdd:pfam00871 162 PYSWYKEHGIRRYGFHGTSHKYVSQRAAKILN---KPLEDLNLITCHLGNGASVCAVRNGKSVDTSMGFTPLEGLVMGTR 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 245 TGDIDPAAVFHLMRNADMNVDELDDLFNKKSGMMGMTGF-GDMREVHRLVAEGDENAKLALDIYVHRIVSYIGAYTAQLG 323
Cdd:pfam00871 239 SGDIDPAIIFYLAETLGMSADEINNTLNKKSGLLGLSGVsSDLRYVEDAYAEGKEDAQLAIKVYVHRLAKYIGSYAASLE 318

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 324 GLDVLTFTAGVGENDEIVRRMVCEKLAPFGVKLDNDKNdTRSKEPRIISTPDSTVTVVVYPTNEELAIAQ 393
Cdd:pfam00871 319 RLDAIVFTGGIGENAAMVRELVLNALEVLGFEIDPERN-NRFGKSGVISTEDSRVKVVVIPTNEELMIAQ 387
ackA TIGR00016
acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in ...
 1-395 8.78e-136

acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in the secretion of acetate. It catalyzes the reaction ATP + acetate = ADP + acetyl phosphate. Some members of this family have been shown to act on propionate as well as acetate. An example of a propionate/acetate kinase is TdcD of E. coli (SP|P11868), an enzyme of an anaerobic pathway of threonine catabolism. It is not known how many members of this family act on additional substrates besides acetate. [Energy metabolism, Fermentation]


Pssm-ID: 272856  Cd Length: 404  Bit Score: 394.47  E-value: 8.78e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856   1 MAKTVLVINSGSSSIKYQLVDLESGEGI-ASGIVEKIGEPIDGHYKYEYNGEKHELDEKVENHEQGLKRVLGFFEEYGPS 79
Cdd:TIGR00016   2 SSMKILVLNAGSSSLKFALFDAVNGEEVlASGLAERIFLPNARIKWVEDGGKKEAELLAGADHQEALKFILNTLLKDKII 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856  80 LEETGIIAVGHRVVQGGDTFPNPALVTPDTTAKVEELAVLAPLHNGPEAKGARVMREL--LPEIPQVYVFDSSFFQQLPK 157
Cdd:TIGR00016  82 KLLSEIDLIGHRVVHGGEKFTDSVIITDEVIQKIKDISPLAPLHNPAHLIGIEAALKLfpLPKAKNVAVFDTAFHQTMPE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 158 ASSTYALNKEVADKYKIKRYGAHGTSHWFVSSQIPEFLGidaEAAKGLKQIVLHIGNGASASAELGGRPIETSMGLTPLE 237
Cdd:TIGR00016 162 EAYLYALPYSWYKEHGVRRYGFHGTSHKYVTQRAAKILN---KPLDDLNLIVCHLGNGASVCAIKNGKSIDTSMGFTPLE 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 238 GLVMGSRTGDIDPAAVFHLMRNADMNVDELDDLFNKKSGMMGMTGF-GDMREVHRLVAEGDENAKLALDIYVHRIVSYIG 316
Cdd:TIGR00016 239 GLMMGTRSGDIDPAIIFYLAETLGMSADDIENTLNKKSGLLGISGLsSDLRDIEDAYAEGNEQAKLAIKVYVHRIAKYIG 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 317 AYTAQLGG-LDVLTFTAGVGENDEIVRRMVCEKLAPFGVKLDNDKND-TRSKEPRIISTPDSTVTVVVYPTNEELAIAQR 394
Cdd:TIGR00016 319 SYIASLEGnLDAIVFTGGIGENAAMVRELVLEKLEVLGFELDPELNNaARSGKSGVISTPESKVKILVIPTNEELMIAQD 398


                  .
gi 1570883856 395 A 395
Cdd:TIGR00016 399 A 399
 
Name Accession Description Interval E-value
AckA COG0282
Acetate kinase [Energy production and conversion];
3-399 0e+00

Acetate kinase [Energy production and conversion];


Pssm-ID: 440051  Cd Length: 395  Bit Score: 581.61  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856   3 KTVLVINSGSSSIKYQLVDLESGEGIASGIVEKIGEPiDGHYKYEY-NGEKHELDEKVENHEQGLKRVLGFFEEYGPSLE 81
Cdd:COG0282     1 MKILVLNAGSSSLKFQLFDMDSEEVLAKGLVERIGLP-GARLKHKDaGGEKVERELPIPDHAAALALVLELLTDHGIIKD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856  82 ETGIIAVGHRVVQGGDTFPNPALVTPDTTAKVEELAVLAPLHNGPEAKGARVMRELLPEIPQVYVFDSSFFQQLPKASST 161
Cdd:COG0282    80 LDEIDAVGHRVVHGGEKFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQTMPEVAYL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 162 YALNKEVADKYKIKRYGAHGTSHWFVSSQIPEFLGIDAEAakgLKQIVLHIGNGASASAELGGRPIETSMGLTPLEGLVM 241
Cdd:COG0282   160 YALPYELYEKYGIRRYGFHGTSHRYVAERAAELLGKPLAD---LRLITAHLGNGASLCAIKNGKSVDTSMGFTPLEGLVM 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 242 GSRTGDIDPAAVFHLMRNADMNVDELDDLFNKKSGMMGMTGF-GDMREVHRLVAEGDENAKLALDIYVHRIVSYIGAYTA 320
Cdd:COG0282   237 GTRSGDIDPGVVLYLMRKEGLSADEVDDLLNKESGLLGLSGIsSDMRDLEEAAASGDERARLALDMFVYRIKKYIGAYAA 316

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1570883856 321 QLGGLDVLTFTAGVGENDEIVRRMVCEKLAPFGVKLDNDKNDTRSKEpRIISTPDSTVTVVVYPTNEELAIAQRANEIV 399
Cdd:COG0282   317 ALGGLDALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANAARGGE-RVISTPDSRVKVLVIPTNEELMIARDTLRLL 394
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 3-399 0e+00

acetate kinase A/propionate kinase 2; Reviewed


Pssm-ID: 234680  Cd Length: 402  Bit Score: 557.03  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856   3 KTVLVINSGSSSIKYQLVDLESGEGIASGIVEKIGEPiDGHYKYEYNGEKHELDEK-VENHEQGLKRVLGFF--EEYGPS 79
Cdd:PRK00180    1 MKILVLNAGSSSLKFQLIDMPNEEVLASGLVERIGLP-DSRIKIKVDGGEKEEEELpIPDHAEALKFLLNTLtdGKLGLI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856  80 LEETGIIAVGHRVVQGGDTFPNPALVTPDTTAKVEELAVLAPLHNGPEAKGARVMRELLPEIPQVYVFDSSFFQQLPKAS 159
Cdd:PRK00180   80 KDLDEITAVGHRVVHGGEKFTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNVPQVAVFDTAFHQTMPEEA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 160 STYALNKEVADKYKIKRYGAHGTSHWFVSSQIPEFLGIDAEaakGLKQIVLHIGNGASASAELGGRPIETSMGLTPLEGL 239
Cdd:PRK00180  160 YLYALPYELYEKYGIRRYGFHGTSHRYVSQRAAELLGKPLE---ELNLITCHLGNGASIAAIKNGKSVDTSMGFTPLEGL 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 240 VMGSRTGDIDPAAVFHLMRNADMNVDELDDLFNKKSGMMGMTGFG-DMREVHRLVAEGDENAKLALDIYVHRIVSYIGAY 318
Cdd:PRK00180  237 VMGTRSGDIDPAIIPYLMEKLGMSVDEIDNLLNKKSGLLGLSGVSsDMRDIEAAAEEGDERAKLALDVFVYRLAKYIGSY 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 319 TAQL-GGLDVLTFTAGVGENDEIVRRMVCEKLAPFGVKLDNDKNDT-RSKEPRIISTPDSTVTVVVYPTNEELAIAQRAN 396
Cdd:PRK00180  317 AAALnGRLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNLAaRFGKEGDISTPDSKVKVLVIPTNEELMIARDTL 396


                  ...
gi 1570883856 397 EIV 399
Cdd:PRK00180  397 RLL 399
ASKHA_NBD_AcK_PK cd24010
nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain ...
 5-393 0e+00

nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain family; The family corresponds to a group of proteins which transfer phosphate from ATP to a short chain aliphatic acid. It includes acetate kinase (AckA) and propionate kinase (TdcD and PduW). Acetate kinase (EC 2.7.2.1), also called acetokinase, catalyzes the formation of acetyl phosphate from acetate and ATP. It can also catalyze the reverse reaction in the presence of a divalent cation. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically. Propionate kinase TdcD (EC 2.7.2.15) catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor. The family also includes propionate kinase PduW (EC 2.7.2.15) that works with phosphate acetyltransferase (pta) to capture exogenous propionate and regenerate propionyl-CoA during degradation of propionate and 1,2-propanediol (1,2-PD). This protein restores growth to an eutQ deletion on ethanolamine and tetrathionate under anoxic conditions. The AcK/PK family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466860  Cd Length: 392  Bit Score: 531.70  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856   5 VLVINSGSSSIKYQLVDLESGEGIASGIVEKIGEPiDGHYKYEY-NGEKHELDEKVENHEQGLKRVLGFFEEYGPSLEET 83
Cdd:cd24010     1 ILVINCGSSSLKFQLFDMPTEEVLASGLVERIGLE-GARLKHKVnNGEKIKEELPIPDHEEALKAILDTLTDPELGVSLD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856  84 GIIAVGHRVVQGGDTFPNPALVTPDTTAKVEELAVLAPLHNGPEAKGARVMRELLPEIPQVYVFDSSFFQQLPKASSTYA 163
Cdd:cd24010    80 EIDAVGHRVVHGGEKFTESVLIDDEVIAAIEDLSPLAPLHNPANLAGIEAARKLLPDVPQVAVFDTAFHQTMPPHAYLYA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 164 LNKEVADKYKIKRYGAHGTSHWFVSSQIPEFLGIDAEAakgLKQIVLHIGNGASASAELGGRPIETSMGLTPLEGLVMGS 243
Cdd:cd24010   160 LPYELYEKYGIRRYGFHGTSHRYVSRRAAELLGKPLED---LNLITCHLGNGASICAIKNGKSVDTSMGLTPLEGLVMGT 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 244 RTGDIDPAAVFHLMRNADMNVDELDDLFNKKSGMMGMTG-FGDMREVHRLVAEGDENAKLALDIYVHRIVSYIGAYTAQL 322
Cdd:cd24010   237 RSGDIDPAIVFYLMKKEGMSVDEIERLLNKKSGLLGISGvSSDMRDIEEAAEEGDERAKLALDVFVYRIKKYIGAYAAAL 316

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1570883856 323 GGLDVLTFTAGVGENDEIVRRMVCEKLAPFGVKLDNDKNDTRSKEPRIISTPDSTVTVVVYPTNEELAIAQ 393
Cdd:cd24010   317 GGVDAIVFTGGIGENSALIRELVCEGLEFLGIELDEEKNKAAGGGEREISTPDSKVKVLVIPTNEELMIAR 387
Acetate_kinase pfam00871
Acetokinase family; This family includes acetate kinase, butyrate kinase and ...
 5-393 2.56e-148

Acetokinase family; This family includes acetate kinase, butyrate kinase and 2-methylpropanoate kinase.


Pssm-ID: 395700  Cd Length: 387  Bit Score: 426.07  E-value: 2.56e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856   5 VLVINSGSSSIKYQLVDLESGEGIASGIVEKIGEPIDGHYKYEYNGEKHELDEKVENHEQGLKRVLGFFEEYGPSLEETG 84
Cdd:pfam00871   2 VLVLNAGSSSIKFQLFDAVIGEVLLSGLAERIGLPNARILWKMNGGKKNAALLAGADHSEALNFILNTLLKHKIIELLAE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856  85 IIAVGHRVVQGGDTFPNPALVTPDTTAKVEELAVLAPLHNGPEAKGARVMRELLPEIPQVYVFDSSFFQQLPKASSTYAL 164
Cdd:pfam00871  82 ITLIGHRVVHGGEKFTESVLITDEVIQGIKDLIPLAPLHNPAHLDGIEEAFKLFPQVKNVAVFDTAFHQTMPEEAYLYAL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 165 NKEVADKYKIKRYGAHGTSHWFVSSQIPEFLGidaEAAKGLKQIVLHIGNGASASAELGGRPIETSMGLTPLEGLVMGSR 244
Cdd:pfam00871 162 PYSWYKEHGIRRYGFHGTSHKYVSQRAAKILN---KPLEDLNLITCHLGNGASVCAVRNGKSVDTSMGFTPLEGLVMGTR 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 245 TGDIDPAAVFHLMRNADMNVDELDDLFNKKSGMMGMTGF-GDMREVHRLVAEGDENAKLALDIYVHRIVSYIGAYTAQLG 323
Cdd:pfam00871 239 SGDIDPAIIFYLAETLGMSADEINNTLNKKSGLLGLSGVsSDLRYVEDAYAEGKEDAQLAIKVYVHRLAKYIGSYAASLE 318

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 324 GLDVLTFTAGVGENDEIVRRMVCEKLAPFGVKLDNDKNdTRSKEPRIISTPDSTVTVVVYPTNEELAIAQ 393
Cdd:pfam00871 319 RLDAIVFTGGIGENAAMVRELVLNALEVLGFEIDPERN-NRFGKSGVISTEDSRVKVVVIPTNEELMIAQ 387
ackA TIGR00016
acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in ...
 1-395 8.78e-136

acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in the secretion of acetate. It catalyzes the reaction ATP + acetate = ADP + acetyl phosphate. Some members of this family have been shown to act on propionate as well as acetate. An example of a propionate/acetate kinase is TdcD of E. coli (SP|P11868), an enzyme of an anaerobic pathway of threonine catabolism. It is not known how many members of this family act on additional substrates besides acetate. [Energy metabolism, Fermentation]


Pssm-ID: 272856  Cd Length: 404  Bit Score: 394.47  E-value: 8.78e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856   1 MAKTVLVINSGSSSIKYQLVDLESGEGI-ASGIVEKIGEPIDGHYKYEYNGEKHELDEKVENHEQGLKRVLGFFEEYGPS 79
Cdd:TIGR00016   2 SSMKILVLNAGSSSLKFALFDAVNGEEVlASGLAERIFLPNARIKWVEDGGKKEAELLAGADHQEALKFILNTLLKDKII 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856  80 LEETGIIAVGHRVVQGGDTFPNPALVTPDTTAKVEELAVLAPLHNGPEAKGARVMREL--LPEIPQVYVFDSSFFQQLPK 157
Cdd:TIGR00016  82 KLLSEIDLIGHRVVHGGEKFTDSVIITDEVIQKIKDISPLAPLHNPAHLIGIEAALKLfpLPKAKNVAVFDTAFHQTMPE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 158 ASSTYALNKEVADKYKIKRYGAHGTSHWFVSSQIPEFLGidaEAAKGLKQIVLHIGNGASASAELGGRPIETSMGLTPLE 237
Cdd:TIGR00016 162 EAYLYALPYSWYKEHGVRRYGFHGTSHKYVTQRAAKILN---KPLDDLNLIVCHLGNGASVCAIKNGKSIDTSMGFTPLE 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 238 GLVMGSRTGDIDPAAVFHLMRNADMNVDELDDLFNKKSGMMGMTGF-GDMREVHRLVAEGDENAKLALDIYVHRIVSYIG 316
Cdd:TIGR00016 239 GLMMGTRSGDIDPAIIFYLAETLGMSADDIENTLNKKSGLLGISGLsSDLRDIEDAYAEGNEQAKLAIKVYVHRIAKYIG 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 317 AYTAQLGG-LDVLTFTAGVGENDEIVRRMVCEKLAPFGVKLDNDKND-TRSKEPRIISTPDSTVTVVVYPTNEELAIAQR 394
Cdd:TIGR00016 319 SYIASLEGnLDAIVFTGGIGENAAMVRELVLEKLEVLGFELDPELNNaARSGKSGVISTPESKVKILVIPTNEELMIAQD 398


                  .
gi 1570883856 395 A 395
Cdd:TIGR00016 399 A 399
PRK07157 PRK07157
acetate kinase; Provisional
 1-398 5.25e-121

acetate kinase; Provisional


Pssm-ID: 235948  Cd Length: 400  Bit Score: 356.74  E-value: 5.25e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856   1 MAKTVLVINSGSSSIKYQLVDLESGEGIASGIVEKIGEPiDGHYKYEYNGEKHELDEKVENHEQGLKRVLGFFEEYG--P 78
Cdd:PRK07157    1 MKAKILVINAGSSSIKWQLFDKENLNLIASGLAERIGLE-NGLIKIKFGKKKYEKEVDMPNHKVAVAVLIEIWEENKliE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856  79 SLEETGIIavGHRVVQGGDTFPNPALVTPDTTAKVEELAVLAPLHNGPEAKGARVMRELLPEIPQVYVFDSSFFQQLPKA 158
Cdd:PRK07157   80 DLEEIELI--GFRVVHGGDYFNGPTKLDDKEISKIEKVAKYAPLHNPGALQTIKAFKKVLPKAKLSASFDTAFHTSIPKI 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 159 SSTYALNKEVADKYKIKRYGAHGTSHWFVSSQIPEFLGIDaeaakGLKQIVLHIGNGASASAELGGRPIETSMGLTPLEG 238
Cdd:PRK07157  158 NYTYPINYEIAKKYGIKKYGFHGISHKFITNKVEKILNKD-----KVNFVNLHIGNGASLCAIKNSKSIDTSMGLTPLAG 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 239 LVMGSRTGDIDPAAVFHLMRNADMNVDELDDLFNKKSGMMGMTGFG-DMREVHRLVAEGDENAKLALDIYVHRIVSYIGA 317
Cdd:PRK07157  233 VMMGTRSGDIDPSIHEFVAKEANMSISEFTDLLNKKSGLLGVSGISsDLRDVIKAAESGNKRAKFALDLYAQKIVDYLAN 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 318 YTAQLGG-LDVLTFTAGVGENDEIVRRMVCEKLAPFGVKLDNDKNDTRSKE---PRIISTPDSTVTVVVYPTNEELAIAQ 393
Cdd:PRK07157  313 YINKIGKkIDAIVFTAGVGENSAFVRELVINKINIPNIKLDKEKNLKKIGEygpIELISTPDSDIPVYVIRTNEELLIAK 392


                  ....*
gi 1570883856 394 RANEI 398
Cdd:PRK07157  393 NAIKL 397
PRK12379 PRK12379
propionate kinase;
4-398 4.40e-112

propionate kinase;


Pssm-ID: 183484  Cd Length: 396  Bit Score: 334.01  E-value: 4.40e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856   4 TVLVINSGSSSIKYQLVDLESGEGIASGIVEKIGEpidGHYKYEYNG-EKHELDEKveNHEQGLKRVlgFFEeygpsLEE 82
Cdd:PRK12379    6 VVLVINCGSSSIKFSVLDASDCEVLMSGIADGINS---ENAFLSVNGgEPAPLAHH--SYEGALKAI--AFE-----LEK 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856  83 TGII----AVGHRVVQGGDTFPNPALVTPDTTAKVEELAVLAPLHNGPEAKGARVMRELLPEIPQVYVFDSSFFQQLPKA 158
Cdd:PRK12379   74 RNLNdsvaLIGHRIAHGGSIFTESVIITDEVIDNIRRVSPLAPLHNYANLSGIEAAQQLFPGVTQVAVFDTSFHQTLAPE 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 159 SSTYALNKEVADKYKIKRYGAHGTSHWFVSSQIPEFLGIDaEAAKGLkqIVLHIGNGASASAELGGRPIETSMGLTPLEG 238
Cdd:PRK12379  154 AYLYGLPWEYYEELGVRRYGFHGTSHRYVSQRAHSLLNLD-EDDSGL--VVAHLGNGASICAVRNGQSVDTSMGMTPLEG 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 239 LVMGSRTGDIDPAAVFHLMRNADMNVDELDDLFNKKSGMMGMTGF-GDMREVHRLVAEGDENAKLALDIYVHRIVSYIGA 317
Cdd:PRK12379  231 LMMGTRSGDVDFGAMAWIASQTGQTLGDLERVVNKESGLLGISGLsSDLRVLEKAWHEGHERAQLAIKTFVHRIARHIAG 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 318 YTAQLGGLDVLTFTAGVGENDEIVRRMVCEKLAPFGVKLDNDKND-TRSKEPRIISTPDSTVTVVVYPTNEELAIAQRAN 396
Cdd:PRK12379  311 HAASLHRLDGIIFTGGIGENSSLIRRLVMEHLAVLGLEIDTEMNNqPNSGGERIISSENSRVICAVIPTNEEKMIALDAI 390


                  ..
gi 1570883856 397 EI 398
Cdd:PRK12379  391 HL 392
PRK12397 PRK12397
acetate/propionate family kinase;
1-393 2.23e-109

acetate/propionate family kinase;


Pssm-ID: 183500  Cd Length: 404  Bit Score: 327.18  E-value: 2.23e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856   1 MAKTVLVINSGSSSIKYQLVDLESGEGIASGIVEKIGEPiDGHYKYEYNGEKHELDEKVENHEQGLKRVLGFFEEYG--P 78
Cdd:PRK12397    1 MSYKIMAINAGSSSLKFQLLEMPQGDMLCQGLIERIGMA-DAQVTIKTHSQKWQETVPVADHRDAVTLLLEKLLGYQiiN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856  79 SLEEtgIIAVGHRVVQGGDTFPNPALVTPDTTAKVEELAVLAPLHNGPEAKGARVMRELLPEIPQVYVFDSSFFQQLPKA 158
Cdd:PRK12397   80 SLRD--IDGVGHRVAHGGEFFKDSTLVTDETLAQIERLAELAPLHNPVNALGIHVFRQLLPDAPSVAVFDTAFHQTLDEP 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 159 SSTYALNKEVADKYKIKRYGAHGTSHWFVSSQIPEFLGIDAEAakgLKQIVLHIGNGASASAELGGRPIETSMGLTPLEG 238
Cdd:PRK12397  158 AYIYPLPWRYYAELGIRRYGFHGTSHKYVSGVLAEKLGVPLSA---LRVICCHLGNGSSICAIKNGRSVNTSMGFTPQSG 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 239 LVMGSRTGDIDPAAVFHLMRNADMNVDELDDLFNKKSGMMGMTGFG-DMREVHRLVAEGDENAKLALDIYVHRIVSYIGA 317
Cdd:PRK12397  235 VMMGTRSGDIDPSILPWIAQREGKTPQQLNQLLNNESGLLGVSGVSsDYRDVEQAANTGNRQAKLALTLFAERIRATIGS 314

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1570883856 318 YTAQLGGLDVLTFTAGVGENDEIVRRMVCEKLAPFGVKLDNDKNdtrSKEPRIISTPDSTVTVVVYPTNEELAIAQ 393
Cdd:PRK12397  315 YIMQMGGLDALVFTGGIGENSARARSAVCHNLQFLGLAVDEEKN---QRNATFIQTENALVKVAVINTNEELMIAQ 387
PRK12440 PRK12440
acetate/propionate family kinase;
5-399 1.75e-97

acetate/propionate family kinase;


Pssm-ID: 183528  Cd Length: 397  Bit Score: 296.77  E-value: 1.75e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856   5 VLVINSGSSSIKYQLVDLESGEGIASGIVEKIGEPiDGHYKYEYNGEKHE--LDEKVENHEQGLKRVLGFFEEYGPSlee 82
Cdd:PRK12440    6 VLVINSGSSSLKFAVIDSVTGEAVLSGLGECFGLE-DARMSWKYQGEKTEiaIEGEDNHHKIAIGRLVGLTEELGFT--- 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856  83 TGIIAVGHRVVQGGDTFPNPALVTPDTTAKVEELAVLAPLHNGPEAKGARVMRELLPEIPQVYVFDSSFFQQLPKASSTY 162
Cdd:PRK12440   82 QDIVAVGHRIVHGGEKFTSTVRIDEEVTAEIESLSDLAPLHNPAGAIGIRAAMAAFPSLPQFAVFDTAFHQTMPKKAFTG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 163 ALNKEVADKYKIKRYGAHGTSHWFVSSQIPEFLGIDAEAAKGlkqIVLHIGNGASASAELGGRPIETSMGLTPLEGLVMG 242
Cdd:PRK12440  162 AIAKELYTDFGIRRYGFHGTSHYFVSREAAKMLNKPIEESSF---ISVHLGNGASVCAIKNGQSVDTSMGFTPLSGLMMG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 243 SRTGDIDPAAVFHLMRNAdMNVDELDDLFNKKSGMMGMTGF-GDMREVHRLVAEGDENAKLALDIYVHRIVSYIGAYTAQ 321
Cdd:PRK12440  239 TRCGDLDPGIIEFLLKKG-WSQEKVFNSLNKKSGFLGVSGLtSDARGILEAMEEGHEGATLAFEVFTYRVAKYIASYLAA 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 322 LGGLDVLTFTAGVGENDEIVRRMVCEKLAPFGVKLDNDKN-DTRSKEPRIISTPDS-TVTVVVYPTNEELAIAQRANEIV 399
Cdd:PRK12440  318 LDSLDGIIFTGGIGENSLPIRREILKNLKLLGFVEDEKGNeDARFGKAGIIAKSELlNAVAMVIPTNEEFVIAQQSVELL 397
PRK07058 PRK07058
acetate/propionate family kinase;
1-405 1.01e-87

acetate/propionate family kinase;


Pssm-ID: 235922  Cd Length: 396  Bit Score: 271.54  E-value: 1.01e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856   1 MAKTVLVINSGSSSIKYQLVDLESGEG--IASGIVEKIGEPIDGHYkyEYNGEKHELDEKVENHEQgLKRVLG-FFEEYG 77
Cdd:PRK07058    2 SKPLLLTFNAGSSTVKIGLFEVDGNEArrIGKGDIDFRRAPLRFHL--RNGGETLDIPLKASVTDD-LHTVLDeTFDWLA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856  78 PSLEETGIIAVGHRVVQGGDTFPNPALVTPDTTAKVEELAVLAPLHNGPEAKGARVMRELLPEIPQVYVFDSSFFQQLPK 157
Cdd:PRK07058   79 AHFDVSELVAVGHRVVHGGDRFAGAVLIDDATLDAIEALVPLAPLHQPQSLRLIRAIRHLRPHLPQTASFDTAFHRTQPD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 158 ASSTYALNKEVADKyKIKRYGAHGTSHWFVSSQIPEflgIDAEAAKGlKQIVLHIGNGASASAELGGRPIETSMGLTPLE 237
Cdd:PRK07058  159 LVRRFAIPRALHDE-GIKRYGFHGLSYKFVAGELRR---RAPELARG-KVVAAHLGSGASLCALDAGKSRDTSMGFSTLD 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 238 GLVMGSRTGDIDPAAVFHLMRNADMNVDELDDLFNKKSGMMGMTGF-GDMREvhrLVAEGDENAKLALDIYVHRIVSYIG 316
Cdd:PRK07058  234 GIPMATRCGALDPGVVLHLLKQEGMSLDEVEDLLYHRSGLLGVSGIsGDTRD---LLASDAPEAREALDLFALRIAGEIA 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 317 AYTAQLGGLDVLTFTAGVGENDEIVRRMVCEKLAPFGVKLDNDKNDTRSkepRIISTPDSTVTVVVYPTNEELAIAQRAN 396
Cdd:PRK07058  311 RLAATLGGLDAVVFTAGIGEHQPAIRAAVCERLAWLGVELDPAANAANA---FTISSRTSRVAAFVIPTDEEQVIADEAF 387


                  ....*....
gi 1570883856 397 EIVTAGEDT 405
Cdd:PRK07058  388 SVLRAMPAT 396
ASKHA_NBD_BK cd24011
nucleotide-binding domain (NBD) of the butyrate kinase (BK) domain family; Butyrate kinase (EC ...
 208-352 1.47e-18

nucleotide-binding domain (NBD) of the butyrate kinase (BK) domain family; Butyrate kinase (EC 2.7.2.7) catalyzes the formation of butyryl-CoA by phosphorylating butyrate in the presence of ATP to form butyryl phosphate. Butyrate kinases exist in many fermentative species of the bacterial and archaeal families. They belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466861  Cd Length: 345  Bit Score: 86.05  E-value: 1.47e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 208 IVLHIGNGASASAELGGRPIETSMGLtPLEGLVMGSRTGDIDPAAVFHLMRNADMNVDELDDLFNKKSGMMGMTGFGDMR 287
Cdd:cd24011   177 IVAHLGGGISVGAHRKGRVIDVNNAL-DGEGPFSPERAGTLPVGDLIKLCFSGKYTLEELKKKLKGKGGLVAYLGTNDFR 255

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1570883856 288 EVHRLVAEGDENAKLALDIYVHRIVSYIGAYTAQLGG-LDVLTFTAGVGENDEIVRRMV--CEKLAPF 352
Cdd:cd24011   256 EVEKRIEAGDEKAKLVLDAMAYQIAKEIGALAAVLKGkVDAIILTGGLAYSKRLVDRIKerVGFIAPV 323
PRK03011 PRK03011
butyrate kinase; Provisional
 208-395 9.30e-13

butyrate kinase; Provisional


Pssm-ID: 235099  Cd Length: 358  Bit Score: 69.03  E-value: 9.30e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 208 IVLHIGNGASASAELGGRPIETSMGLtPLEGLVMGSRTGDIDPAAVFHLMRNADMNVDELDDLFNKKSGMMGMTGFGDMR 287
Cdd:PRK03011  179 IVAHLGGGISVGAHRKGRVIDVNNAL-DGEGPFSPERAGGLPVGDLVELCFSGKYTKEELKKKLVGKGGLVAYLGTNDAR 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570883856 288 EVHRLVAEGDENAKLALDIYVHRIVSYIGAYTAQLGG-LDVLTFTAGVGENDEIV---RRMVcEKLAPfgvkldndkndt 363
Cdd:PRK03011  258 EVEKRIEEGDEKAKLVYEAMAYQIAKEIGAMAAVLKGkVDAIVLTGGLAYSKRLVeriKERV-SFIAP------------ 324

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1570883856 364 rskepriistpdstvtVVVYP-TNEELAIAQRA 395
Cdd:PRK03011  325 ----------------VIVYPgEDEMEALAEGA 341
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH