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Concise Results
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protein AHNAK2 isoform 1 [Homo sapiens]
Protein Classification
List of domain hits
Name
Accession
Description
Interval
E-value
TamB super family
cl34519 Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, ...
3328-3832
3.16e-09
Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, and vesicular transport];
COG2911 :Pssm-ID: 442155 [Multi-domain]
Cd Length: 766
Bit Score: 63.91
E-value: 3.16e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3328 QAS VD VS A PKAEA D V S LPSM - Q G D L KTTD L SIQLPSVDLEVQAGQV D VKL PEG HVP --- EGAGLKGHLPKVEMP S FKMPK 3403
Cdd:COG2911 11 DDG VD LE A DRLRL D W S PLAL l R G R L CIDE L ALSASLDGDRLRLDNL D LDA PEG ALS gll DLVQATLDAEGLDLA S SALDD 90
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3404 V DL K S P -- QVDIK G ---- PK LD LKV pka EVTV PD VE v S L PSVEVDV q A PRAKL DG --- AR L EG D LS LA EKDVTA k D S K FK 3474
Cdd:COG2911 91 L DL R S G gn RLTLS G nlsa AS LD GDL --- DLDA PD LA - D L AALLPGL - A GSLSG DG lds LS L DA D GT LA QHRLDL - D A K GE 164
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3475 MPKFKMP --- SFGVSAP G RSIEAS - L DVSAPKVE A DVS LS SMQ G DLKATD L SIQ ----------- PPSA DL EVQAVQVDV 3539
Cdd:COG2911 165 PASLSLA lsg GLDRDDG G TLSRLD f L NTGRWGLA A PAT LS YDD G RVTLGP L CLA gggslclsgtl GGTL DL QLRLKNLPL 244
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3540 E LL EGPV P EGA GL K G hlpkvempslktpkv D L K G p QI D VK G PKLDLK G p K A EVRVPD vevslp SVEVDVQAPKAK L DA G R 3619
Cdd:COG2911 245 A LL NPFL P DDL GL S G --------------- T L N G - DA D LS G GLANPQ G - D A SLSLSG ------ DLTLNDGLGGLP L GL G D 301
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3620 L EGDLS LA DKDV T A k D SKFKMPKFKMP S FRV S A P ------- GKSMEASVDVSAP ------------------ KVEA D VS L 3674
Cdd:COG2911 302 L TLNAR LA NGRL T L - D LTLDGGGLGTL S LSG S V P ladglpp SAPLDGNLRLDNL dlallnpllpgvlerlsg QLNG D LR L 380
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3675 ------ P SMQ G D L KTT D LSIQP P SADLKVQAGQMDVKLPEGQV pegaglkehlp KVEMPSLKMPK -- VD L K G p Q VD IK G P 3746
Cdd:COG2911 381 sgtlaa P QLN G Q L TLD D GRLKL P ALGVRLTDINLRLRFDGDRL ----------- TLDGLTADSGG gt LT L S G - T VD LD G L 448
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3747 K ---- L D LK VSKAE V TA P D --- VE VS ---------- L P SVEVD V QA PRA KLDSAQ L EGDLSLADK DV TAKDSKFK mpkfk 3809
Cdd:COG2911 449 S wpad L T LK GDNLR V LN P P dyt AT VS gdltltgtpd G P TLSGN V TV PRA RITLPE L PPSAVSLSD DV VVVNRPPE ----- 523
570 580
....*....|....*....|...
gi 156766050 3810 m P SFGVS A P G KSIEASVH V SAPK 3832
Cdd:COG2911 524 - P VPEEE A A G LPLDLDLN V NLGD 545
PDZ_canonical super family
cl49608 canonical PDZ domain; Canonical PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs ...
125-181
1.44e-07
canonical PDZ domain; Canonical PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain. PDZ domains usually bind to short specific peptide sequences located at the C-terminal end of their partner proteins known as PDZ binding motifs. These domains can also interact with internal peptide motifs and certain lipids, and can take part in a head-to-tail oligomerization with other PDZ domains. The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping mediated by beta-strands. The canonical PDZ domain contains six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2), arranged in the order: beta-strands A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F.
cd06752 :Pssm-ID: 483948 [Multi-domain]
Cd Length: 83
Bit Score: 51.93
E-value: 1.44e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 125 G YSVT GG GDQ -- GIF VKQ V LK DS S A AK L f N L R EGDQ L LS TT - V F FE N I KYED A L K I L QYS 181
Cdd:cd06752 14 G FNIR GG KAS gl GIF ISK V IP DS D A HR L - G L K EGDQ I LS VN g V D FE D I EHSE A V K V L KTA 72
TamB super family
cl34519 Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, ...
3990-4527
2.37e-07
Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, and vesicular transport];
COG2911 :Pssm-ID: 442155 [Multi-domain]
Cd Length: 766
Bit Score: 57.74
E-value: 2.37e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3990 S VD VT A PKVEA D V S LPSM - Q G D L KATD L SVQPPSADLEVQAGQV D VKL PEG PV pe GAS L KGHLPKVQMPSFKMPKVD L KG 4068
Cdd:COG2911 13 G VD LE A DRLRL D W S PLAL l R G R L CIDE L ALSASLDGDRLRLDNL D LDA PEG AL -- SGL L DLVQATLDAEGLDLASSA L DD 90
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 4069 PQIDVK G PK L D L K G P -------- KAEVT APD VK m S L SSMEVDV q A PRAKL DG --- VQ L EG D LS LA DKDVTA k D S K FKMPK 4137
Cdd:COG2911 91 LDLRSG G NR L T L S G N lsaasldg DLDLD APD LA - D L AALLPGL - A GSLSG DG lds LS L DA D GT LA QHRLDL - D A K GEPAS 167
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 4138 FKMPSF G VSAPGKSME ---- ASVDVSELKAK A DVS L PSMQ G DLKTTD L SIQ ----------- SPSA DL EVQAGQVDVK L P 4202
Cdd:COG2911 168 LSLALS G GLDRDDGGT lsrl DFLNTGRWGLA A PAT L SYDD G RVTLGP L CLA gggslclsgtl GGTL DL QLRLKNLPLA L L 247
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 4203 EGP LP KGA GL K G hlpkvqmpclkmpkv A L K G pqvdvkgp KL DL K G PK A D vmt P VVEV SL --- PSMEVDVEAP G AK L DSVR 4279
Cdd:COG2911 248 NPF LP DDL GL S G --------------- T L N G -------- DA DL S G GL A N --- P QGDA SL sls GDLTLNDGLG G LP L GLGD 301
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 4280 L EGDLS LA DKDM T A k D SKFKMPKFKMP S FGV S A P ------- GKSIEAS L DVSA L ------------------ KVEA D VS L 4334
Cdd:COG2911 302 L TLNAR LA NGRL T L - D LTLDGGGLGTL S LSG S V P ladglpp SAPLDGN L RLDN L dlallnpllpgvlerlsg QLNG D LR L 380
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 4335 ------ P SMQ G D L KTTHLSIQP P SADLEVQAGQEDVKLPEG ------- PVHE G A G --- L K G HLP k L QMP S FKVP k VD LKG 4398
Cdd:COG2911 381 sgtlaa P QLN G Q L TLDDGRLKL P ALGVRLTDINLRLRFDGD rltldgl TADS G G G tlt L S G TVD - L DGL S WPAD - LT LKG 458
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 4399 PQID V NV P K l D LKG pkve VT S PN L DVS ---- L P SMEVDIQA P G A KLDSTR L EGDLSLADK DV TAKDSKFK mpkfkm P SFG 4474
Cdd:COG2911 459 DNLR V LN P P - D YTA ---- TV S GD L TLT gtpd G P TLSGNVTV P R A RITLPE L PPSAVSLSD DV VVVNRPPE ------ P VPE 527
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 156766050 4475 MLSP G KSIEVSVD V SAPK ------------ MEA D MSI ------- P SMQ G DLKTTDL R IQ A PSAD L EVQA G QV 4527
Cdd:COG2911 528 EEAA G LPLDLDLN V NLGD dvrvrgfgldar LGG D LRL tgtpgga P RLT G EINLVRG R YN A YGQR L TIER G SI 599
TamB super family
cl34519 Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, ...
854-1456
1.21e-06
Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, and vesicular transport];
COG2911 :Pssm-ID: 442155 [Multi-domain]
Cd Length: 766
Bit Score: 55.43
E-value: 1.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 854 D S VD VS A PKVEA D V S LSSM - Q G D L KATD L SIQPPSADLEVQAGQV D VKL PEG pvp EGA G pkvhlpkvemp SFKMPKVD L K 932
Cdd:COG2911 12 D G VD LE A DRLRL D W S PLAL l R G R L CIDE L ALSASLDGDRLRLDNL D LDA PEG --- ALS G ----------- LLDLVQAT L D 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 933 GPQI D VKG --- PK LDL KGPKAEV T A p D G EV S LP S MEV D VQAQ ---------------- KAKL DG --- AW L EG D LS LA DKD 990
Cdd:COG2911 78 AEGL D LAS sal DD LDL RSGGNRL T L - S G NL S AA S LDG D LDLD apdladlaallpglag SLSG DG lds LS L DA D GT LA QHR 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 991 VTA k D S K FKMPKFKMP --- SFGVSAP G KSIK - ALVDVSAPKVE A DLS L PSMQ G DLKTTD L SIQ ----------- PAST DL 1055
Cdd:COG2911 157 LDL - D A K GEPASLSLA lsg GLDRDDG G TLSR l DFLNTGRWGLA A PAT L SYDD G RVTLGP L CLA gggslclsgtl GGTL DL 235
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1056 KVQADQVDVK L PEGH LP EGA GL K G hlpkvempsfkmpkv A L K G p QV D VK G pkl D L KS P KAEV tap DVEV S L p SVEVDVEA 1135
Cdd:COG2911 236 QLRLKNLPLA L LNPF LP DDL GL S G --------------- T L N G - DA D LS G --- G L AN P QGDA --- SLSL S G - DLTLNDGL 292
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1136 P G AK L DSAR L EGELS LA DKDV T A k D SRFKMPKFKMP S FGA S A P ------- GKSIEASVDVSAP ----------------- 1191
Cdd:COG2911 293 G G LP L GLGD L TLNAR LA NGRL T L - D LTLDGGGLGTL S LSG S V P ladglpp SAPLDGNLRLDNL dlallnpllpgvlerls 371
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1192 - KVEA D VS L ------ P SMQ G D L KTT D LSIQP P SADLEVHAGQVDVKL --------- L EGHVPE G AG - FK G hlpkvqmpsl 1254
Cdd:COG2911 372 g QLNG D LR L sgtlaa P QLN G Q L TLD D GRLKL P ALGVRLTDINLRLRF dgdrltldg L TADSGG G TL t LS G ---------- 441
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1255 kmp K VDL K G PQVEVR gpk L D LKG HKAE V TAHE --- VA VS l PSVEVDMQAP G AK L D G aqldgdlsladk D VT AKDSKFKM P 1331
Cdd:COG2911 442 --- T VDL D G LSWPAD --- L T LKG DNLR V LNPP dyt AT VS - GDLTLTGTPD G PT L S G ------------ N VT VPRARITL P 502
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1332 kfkmpsfgvsapg KSIEAS V D LS APK V EADMSLPSMQGDLKTTD lsiq P PST DL ELQA G Q l DV KL pegpvp E G A GL KGH L 1411
Cdd:COG2911 503 ------------- ELPPSA V S LS DDV V VVNRPPEPVPEEEAAGL ---- P LDL DL NVNL G D - DV RV ------ R G F GL DAR L 558
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 156766050 1412 --- PK L QMPSFKV P ---- KVD L KGPEIDIK G PK L DLK ----------- DP KVEVT A ---- P DV EVSL 1456
Cdd:COG2911 559 ggd LR L TGTPGGA P rltg EIN L VRGRYNAY G QR L TIE rgsitfngppl DP YLDIE A vrtv D DV TAGV 625
AsmA super family
cl34531 Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall ...
2741-3135
2.03e-06
Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall/membrane/envelope biogenesis];
COG2982 :Pssm-ID: 442221 [Multi-domain]
Cd Length: 491
Bit Score: 54.27
E-value: 2.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2741 MP E VD L K GP Q I DVK ----- GP N V D LKGPK A EVT A PD vkmslssmev DVQ A PRAKLDGARLE - G D L SLA D KGMT A K dskfk 2814
Cdd:COG2982 106 VD E IT L D GP V I NLE rdadg RA N W D FLLAA A AAA A DA ---------- EAS A WSLDIGRLEIT d G R L VYD D AASG A D ----- 170
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2815 mpk FKMPSFGVSAP G K S IEASVDV S e LKVEAD G SFPSMQ G DL k TTDIRIQ P PSAQ L EVQA G QVDVK L p E G H V p EG AGL K G 2894
Cdd:COG2982 171 --- LTLDDLNLTLS G P S LDGPFRL S - GSGRLN G QPLTLD G KI - GGLLALG P YPLK L DLRS G DLRLS L - D G T V - DL AGL D G 243
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2895 H L p KVQM PS FK -- MPKVDLKG P Q idvk GPKLD L K G P kae V TA PDVEVS L PSV evdveap RAK L DGAR L E GDLS LADK D VT 2972
Cdd:COG2982 244 Q L - ALSG PS LR dl LALLGVTL P E ---- PGPFS L S G R --- L TA DGDRLR L EDL ------- KGT L GDSD L T GDLS VTGG D RP 308
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2973 A KDSKFKMPKFKMPSFGVS AP GKSIEVSVDVSAPKVE A EVS L PSMQ ---------- GD LK TTDISIEPPS A Q L EVQA G QV 3042
Cdd:COG2982 309 A LTGDLASDRLDLDDLLPA AP AAAAAGAPAAARGLPD A PLD L SALR aldadvrlsa DS LK LGGLPLGDLA A H L TLDD G RL 388
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3043 DL KLPEGHVPE G A g L K G H L pklqmpsfkmp KV D RK G PQID V KG p KL D L K G PKTDVTA PD VEVSQP ----- GMEV D VEAP G 3117
Cdd:COG2982 389 DL DPLSAGLYG G T - L S G S L ----------- TL D AR G DPPR V AL - KL S L S G VDLGPLL PD LAGFDR lsgtl NGDL D LSGT G 455
410 420
....*....|....*....|
gi 156766050 3118 AKLDG -- A R L E G DL SL ADK D 3135
Cdd:COG2982 456 NSVAA ll A S L N G SA SL SLG D 475
AsmA super family
cl34531 Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall ...
1429-1815
2.50e-06
Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall/membrane/envelope biogenesis];
COG2982 :Pssm-ID: 442221 [Multi-domain]
Cd Length: 491
Bit Score: 53.89
E-value: 2.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1429 P EI DIK GP KLD L KDPKVEVTAP D VEVSLPSVEV D V EA PGAK LD G GRLE edms LA D KD L TTK D SKFKM p KFKMPSFGVSAP 1508
Cdd:COG2982 107 D EI TLD GP VIN L ERDADGRANW D FLLAAAAAAA D A EA SAWS LD I GRLE ---- IT D GR L VYD D AASGA - DLTLDDLNLTLS 181
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1509 G K S IEASVDV S A pkv EADVSLPSMQG D L K AT - D L SIQ P PSAD L EVQA G QVDVK L p E G P V S e G AGL K G H L p KVQM PS FK -- 1585
Cdd:COG2982 182 G P S LDGPFRL S G --- SGRLNGQPLTL D G K IG g L L ALG P YPLK L DLRS G DLRLS L - D G T V D - L AGL D G Q L - ALSG PS LR dl 255
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1586 MPKVDLKG P Q idvk GPKLD L K G pkvevtapdv KMSLSSMEVDVQAPRAK L DGAQ L E GDLS LADKAVT A KDSKFKMPKFKM 1665
Cdd:COG2982 256 LALLGVTL P E ---- PGPFS L S G ---------- RLTADGDRLRLEDLKGT L GDSD L T GDLS VTGGDRP A LTGDLASDRLDL 321
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1666 PSFGVS AP GKSIEASVDVSEPKVE A DVS L PSMQ ---------- GD LK TTD L SIQSPS A D L EVQA G QVNVKLPEGP L PE G A 1735
Cdd:COG2982 322 DDLLPA AP AAAAAGAPAAARGLPD A PLD L SALR aldadvrlsa DS LK LGG L PLGDLA A H L TLDD G RLDLDPLSAG L YG G T 401
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1736 g FK G H L pkvqmpslkmp KVALK G PQMD V KG p KL D L K G PKAEVMA PD VEVSLP ----- SVEV D VEAP G AKLDSVR -- L E G D 1808
Cdd:COG2982 402 - LS G S L ----------- TLDAR G DPPR V AL - KL S L S G VDLGPLL PD LAGFDR lsgtl NGDL D LSGT G NSVAALL as L N G S 468
....*..
gi 156766050 1809 L SL ADK D 1815
Cdd:COG2982 469 A SL SLG D 475
AsmA super family
cl34531 Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall ...
2356-2803
3.12e-06
Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall/membrane/envelope biogenesis];
COG2982 :Pssm-ID: 442221 [Multi-domain]
Cd Length: 491
Bit Score: 53.50
E-value: 3.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2356 SMQ GDL ktt D LS VQ P psa DLE V QA G Q V DVKL P E G PVPE gaglkghl P KLQMPSFKM p KVD ---- L K G ---- PQ I DVK GP K 2427
Cdd:COG2982 51 TID GDL --- S LS LF P --- WPG V TL G D V TLSN P D G FGGP -------- P LASAERLEL - DLA llpl L S G elev DE I TLD GP V 115
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2428 LD L KGPKTDVMAP D VEVSQPSVEV D V EA PGAK LD gaw L e G D L SVA D KDVTTK D SRFKI p KFKMPSFGVSAP G K S IEASVD 2507
Cdd:COG2982 116 IN L ERDADGRANW D FLLAAAAAAA D A EA SAWS LD --- I - G R L EIT D GRLVYD D AASGA - DLTLDDLNLTLS G P S LDGPFR 190
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2508 V S A p KVEAD G SLSSMQ G DL k ATD L SIQ P PSAD L EVQA G QVDVK L p E G P V p EG AGL K G H L pkvqmpsfkmpem D L K GP Q L D 2587
Cdd:COG2982 191 L S G - SGRLN G QPLTLD G KI - GGL L ALG P YPLK L DLRS G DLRLS L - D G T V - DL AGL D G Q L ------------- A L S GP S L R 253
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2588 VKGPK L DLKG P KAEVTAPDVEMSLSSMEVDVQAPRAK L DGAR L E GDLS LADKGVT A KDSKFKMPKFKMPSFRVS AP GESI 2667
Cdd:COG2982 254 DLLAL L GVTL P EPGPFSLSGRLTADGDRLRLEDLKGT L GDSD L T GDLS VTGGDRP A LTGDLASDRLDLDDLLPA AP AAAA 333
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2668 ----------- E A LV D V S E L K - VE AD MS L PS mq GD LK TTDISIQPPS A Q L EVQA G QV D VKLPEGHVPE G A g L K G H L --- P 2732
Cdd:COG2982 334 agapaaarglp D A PL D L S A L R a LD AD VR L SA -- DS LK LGGLPLGDLA A H L TLDD G RL D LDPLSAGLYG G T - L S G S L tld A 410
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 156766050 2733 KLQM P SFK mpe VD L KGPQI D VKGPNV DL K G PKAEVTAPDVKMS LS SMEVD V Q A PR A K L D G arl EGD LSL A D 2803
Cdd:COG2982 411 RGDP P RVA --- LK L SLSGV D LGPLLP DL A G FDRLSGTLNGDLD LS GTGNS V A A LL A S L N G --- SAS LSL G D 475
PTZ00121 super family
cl31754 MAEBL; Provisional
427-677
9.79e-04
MAEBL; Provisional
PTZ00121 :Pssm-ID: 173412 [Multi-domain]
Cd Length: 2084
Bit Score: 45.90
E-value: 9.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 427 Q A Q E TAV A QR K PR A QPT pgm SREG E GEGLQSLEIGI A RLSLRDTT E GGTQIGPP E IRVRVHDL K TP --- K FAFSTE K EP E 503
Cdd:PTZ00121 1553 K A E E LKK A EE K KK A EEA --- KKAE E DKNMALRKAEE A KKAEEARI E EVMKLYEE E KKMKAEEA K KA eea K IKAEEL K KA E 1629
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 504 R E RRLSTPQRG K RQDASS KA GTGL K G EE VEGA gwmpg REPTTHAE A QG D EGDG EE glqr TRIT EE QD K GREDTEGQIRMP 583
Cdd:PTZ00121 1630 E E KKKVEQLKK K EAEEKK KA EELK K A EE ENKI ----- KAAEEAKK A EE D KKKA EE ---- AKKA EE DE K KAAEALKKEAEE 1700
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 584 KF K IPS L GWSPSKHT K TGR E KATEDT E QGREG E ATATADRREQRRT EE GL KD K E DSDSMTNTT K IQLIHD E KRL K KEQIL 663
Cdd:PTZ00121 1701 AK K AEE L KKKEAEEK K KAE E LKKAEE E NKIKA E EAKKEAEEDKKKA EE AK KD E E EKKKIAHLK K EEEKKA E EIR K EKEAV 1780
250
....*....|....
gi 156766050 664 T E K E VATK D S K FK M 677
Cdd:PTZ00121 1781 I E E E LDEE D E K RR M 1794
AsmA super family
cl34531 Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall ...
1759-2145
1.39e-03
Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall/membrane/envelope biogenesis];
COG2982 :Pssm-ID: 442221 [Multi-domain]
Cd Length: 491
Bit Score: 45.03
E-value: 1.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1759 PQMDVK GP KLD L KGPKAEVMAP D VEVSLPSVEV D V EA PGAK -- LDSVRLE - G D L SLA D K ---- D V T AK D SKFKM pkfkmp 1831
Cdd:COG2982 107 DEITLD GP VIN L ERDADGRANW D FLLAAAAAAA D A EA SAWS ld IGRLEIT d G R L VYD D A asga D L T LD D LNLTL ------ 180
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1832 sf GVSAPGKSIEA S VDVSAPKVEAEVSLP - SMQGD L KTTD L CIP L P S A DL VVQA - G Q VD M klpegqvpeg AGL K G H L p KV 1909
Cdd:COG2982 181 -- SGPSLDGPFRL S GSGRLNGQPLTLDGK i GGLLA L GPYP L KLD L R S G DL RLSL d G T VD L ---------- AGL D G Q L - AL 247
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1910 DM PS FK -- MPKVDLKG P QTDVKGAKLD L KGPKAEVTAP D V evslpsmevdvqaq K AK L DGAR L E GDLS LADK D MT A KDSK 1987
Cdd:COG2982 248 SG PS LR dl LALLGVTL P EPGPFSLSGR L TADGDRLRLE D L -------------- K GT L GDSD L T GDLS VTGG D RP A LTGD 313
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1988 FKMPKFKMPSFGVS AP GRSIEASVDVPAPKVE A DVS L PSMQ ---------- GD LK TTD L SIQPPS A D L KVQT G QV D VKLP 2057
Cdd:COG2982 314 LASDRLDLDDLLPA AP AAAAAGAPAAARGLPD A PLD L SALR aldadvrlsa DS LK LGG L PLGDLA A H L TLDD G RL D LDPL 393
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2058 EGHVPE G A g L K G H L pkvempslkmp KV D LK G PQVDIKG p KL D L KDPKVEMRV PD VEVSLP ----- SMEV D VQAPRAKLDS 2132
Cdd:COG2982 394 SAGLYG G T - L S G S L ----------- TL D AR G DPPRVAL - KL S L SGVDLGPLL PD LAGFDR lsgtl NGDL D LSGTGNSVAA 460
410
....*....|....*
gi 156766050 2133 -- A H L Q G DLT L ANK D 2145
Cdd:COG2982 461 ll A S L N G SAS L SLG D 475
AsmA super family
cl34531 Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall ...
3079-3384
2.83e-03
Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall/membrane/envelope biogenesis];
COG2982 :Pssm-ID: 442221 [Multi-domain]
Cd Length: 491
Bit Score: 43.87
E-value: 2.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3079 PQ I DVK GP KLD L KGPKTDVTAP D VEVSQPGMEV D V EA PGAK LD GA RLE --- G D L SLA D K ---- D V T AK D SKFKM pkfkmp 3151
Cdd:COG2982 107 DE I TLD GP VIN L ERDADGRANW D FLLAAAAAAA D A EA SAWS LD IG RLE itd G R L VYD D A asga D L T LD D LNLTL ------ 180
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3152 sf GVSAPGKSIEVLVDVSAPKVEAD L SL p SMQ G D L KNTDISI eppsa Q L EVQA G QVDVK L p E G H V l EG AGL K G H L p K L QM 3231
Cdd:COG2982 181 -- SGPSLDGPFRLSGSGRLNGQPLT L DG - KIG G L L ALGPYPL ----- K L DLRS G DLRLS L - D G T V - DL AGL D G Q L - A L SG 249
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3232 PS FK -- MPKVDRKG P Q idik GPKLD L K G p KMDVTAPDVEVSQPS mevdveapg AK L DGAR L E GDLS LADK D VT A KDSKFK 3309
Cdd:COG2982 250 PS LR dl LALLGVTL P E ---- PGPFS L S G - RLTADGDRLRLEDLK --------- GT L GDSD L T GDLS VTGG D RP A LTGDLA 315
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3310 MPKFKMPSYRAS AP GKSIQASVDVSAPKAE A DVS L PSMQ ---------- GD LK TTD L SIQLPSVD L EVQA G QV D VKLPEG 3379
Cdd:COG2982 316 SDRLDLDDLLPA AP AAAAAGAPAAARGLPD A PLD L SALR aldadvrlsa DS LK LGG L PLGDLAAH L TLDD G RL D LDPLSA 395
....*
gi 156766050 3380 HVPE G 3384
Cdd:COG2982 396 GLYG G 400
Name
Accession
Description
Interval
E-value
TamB
COG2911 Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, ...
3328-3832
3.16e-09
Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 442155 [Multi-domain]
Cd Length: 766
Bit Score: 63.91
E-value: 3.16e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3328 QAS VD VS A PKAEA D V S LPSM - Q G D L KTTD L SIQLPSVDLEVQAGQV D VKL PEG HVP --- EGAGLKGHLPKVEMP S FKMPK 3403
Cdd:COG2911 11 DDG VD LE A DRLRL D W S PLAL l R G R L CIDE L ALSASLDGDRLRLDNL D LDA PEG ALS gll DLVQATLDAEGLDLA S SALDD 90
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3404 V DL K S P -- QVDIK G ---- PK LD LKV pka EVTV PD VE v S L PSVEVDV q A PRAKL DG --- AR L EG D LS LA EKDVTA k D S K FK 3474
Cdd:COG2911 91 L DL R S G gn RLTLS G nlsa AS LD GDL --- DLDA PD LA - D L AALLPGL - A GSLSG DG lds LS L DA D GT LA QHRLDL - D A K GE 164
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3475 MPKFKMP --- SFGVSAP G RSIEAS - L DVSAPKVE A DVS LS SMQ G DLKATD L SIQ ----------- PPSA DL EVQAVQVDV 3539
Cdd:COG2911 165 PASLSLA lsg GLDRDDG G TLSRLD f L NTGRWGLA A PAT LS YDD G RVTLGP L CLA gggslclsgtl GGTL DL QLRLKNLPL 244
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3540 E LL EGPV P EGA GL K G hlpkvempslktpkv D L K G p QI D VK G PKLDLK G p K A EVRVPD vevslp SVEVDVQAPKAK L DA G R 3619
Cdd:COG2911 245 A LL NPFL P DDL GL S G --------------- T L N G - DA D LS G GLANPQ G - D A SLSLSG ------ DLTLNDGLGGLP L GL G D 301
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3620 L EGDLS LA DKDV T A k D SKFKMPKFKMP S FRV S A P ------- GKSMEASVDVSAP ------------------ KVEA D VS L 3674
Cdd:COG2911 302 L TLNAR LA NGRL T L - D LTLDGGGLGTL S LSG S V P ladglpp SAPLDGNLRLDNL dlallnpllpgvlerlsg QLNG D LR L 380
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3675 ------ P SMQ G D L KTT D LSIQP P SADLKVQAGQMDVKLPEGQV pegaglkehlp KVEMPSLKMPK -- VD L K G p Q VD IK G P 3746
Cdd:COG2911 381 sgtlaa P QLN G Q L TLD D GRLKL P ALGVRLTDINLRLRFDGDRL ----------- TLDGLTADSGG gt LT L S G - T VD LD G L 448
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3747 K ---- L D LK VSKAE V TA P D --- VE VS ---------- L P SVEVD V QA PRA KLDSAQ L EGDLSLADK DV TAKDSKFK mpkfk 3809
Cdd:COG2911 449 S wpad L T LK GDNLR V LN P P dyt AT VS gdltltgtpd G P TLSGN V TV PRA RITLPE L PPSAVSLSD DV VVVNRPPE ----- 523
570 580
....*....|....*....|...
gi 156766050 3810 m P SFGVS A P G KSIEASVH V SAPK 3832
Cdd:COG2911 524 - P VPEEE A A G LPLDLDLN V NLGD 545
PDZ_PDZD11-like
cd06752 PDZ domain of PDZ domain-containing protein 11, and related domains; PDZ (PSD-95 (Postsynaptic ...
125-181
1.44e-07
PDZ domain of PDZ domain-containing protein 11, and related domains; PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain of PDZD11, and related domains. PDZD11 (also known as ATPase-interacting PDZ protein, plasma membrane calcium ATPase-interacting single-PDZ protein, PMCA-interacting single-PDZ protein, PISP) is involved in the dynamic assembly of apical junctions (AJs). It is recruited by PLEKHA7 to AJs to promote the efficient junctional recruitment and stabilization of nectins, and the efficient early phases of assembly of AJs in epithelial cells. The PDZD11 PDZ domain binds nectin-1 and nectin-3. PDZD11 also binds to a PDZ binding motif located in the C-terminal tail of the human sodium-dependent multivitamin transporter, to the cytoplasmic tail of the Menkes copper ATPase ATP7A, and to the cytoplasmic tail of all plasma membrane Ca2+-ATPase b-splice variants. PDZ domains usually bind in a sequence-specific manner to short peptide sequences located at the C-terminal end of their partner proteins (known as PDZ binding motifs). The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping mediated by beta-strands. This PDZD11-like family domain is a canonical PDZ domain containing six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2), arranged in the order: beta-strands A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F.
Pssm-ID: 467234 [Multi-domain]
Cd Length: 83
Bit Score: 51.93
E-value: 1.44e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 125 G YSVT GG GDQ -- GIF VKQ V LK DS S A AK L f N L R EGDQ L LS TT - V F FE N I KYED A L K I L QYS 181
Cdd:cd06752 14 G FNIR GG KAS gl GIF ISK V IP DS D A HR L - G L K EGDQ I LS VN g V D FE D I EHSE A V K V L KTA 72
TamB
COG2911 Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, ...
3990-4527
2.37e-07
Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 442155 [Multi-domain]
Cd Length: 766
Bit Score: 57.74
E-value: 2.37e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3990 S VD VT A PKVEA D V S LPSM - Q G D L KATD L SVQPPSADLEVQAGQV D VKL PEG PV pe GAS L KGHLPKVQMPSFKMPKVD L KG 4068
Cdd:COG2911 13 G VD LE A DRLRL D W S PLAL l R G R L CIDE L ALSASLDGDRLRLDNL D LDA PEG AL -- SGL L DLVQATLDAEGLDLASSA L DD 90
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 4069 PQIDVK G PK L D L K G P -------- KAEVT APD VK m S L SSMEVDV q A PRAKL DG --- VQ L EG D LS LA DKDVTA k D S K FKMPK 4137
Cdd:COG2911 91 LDLRSG G NR L T L S G N lsaasldg DLDLD APD LA - D L AALLPGL - A GSLSG DG lds LS L DA D GT LA QHRLDL - D A K GEPAS 167
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 4138 FKMPSF G VSAPGKSME ---- ASVDVSELKAK A DVS L PSMQ G DLKTTD L SIQ ----------- SPSA DL EVQAGQVDVK L P 4202
Cdd:COG2911 168 LSLALS G GLDRDDGGT lsrl DFLNTGRWGLA A PAT L SYDD G RVTLGP L CLA gggslclsgtl GGTL DL QLRLKNLPLA L L 247
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 4203 EGP LP KGA GL K G hlpkvqmpclkmpkv A L K G pqvdvkgp KL DL K G PK A D vmt P VVEV SL --- PSMEVDVEAP G AK L DSVR 4279
Cdd:COG2911 248 NPF LP DDL GL S G --------------- T L N G -------- DA DL S G GL A N --- P QGDA SL sls GDLTLNDGLG G LP L GLGD 301
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 4280 L EGDLS LA DKDM T A k D SKFKMPKFKMP S FGV S A P ------- GKSIEAS L DVSA L ------------------ KVEA D VS L 4334
Cdd:COG2911 302 L TLNAR LA NGRL T L - D LTLDGGGLGTL S LSG S V P ladglpp SAPLDGN L RLDN L dlallnpllpgvlerlsg QLNG D LR L 380
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 4335 ------ P SMQ G D L KTTHLSIQP P SADLEVQAGQEDVKLPEG ------- PVHE G A G --- L K G HLP k L QMP S FKVP k VD LKG 4398
Cdd:COG2911 381 sgtlaa P QLN G Q L TLDDGRLKL P ALGVRLTDINLRLRFDGD rltldgl TADS G G G tlt L S G TVD - L DGL S WPAD - LT LKG 458
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 4399 PQID V NV P K l D LKG pkve VT S PN L DVS ---- L P SMEVDIQA P G A KLDSTR L EGDLSLADK DV TAKDSKFK mpkfkm P SFG 4474
Cdd:COG2911 459 DNLR V LN P P - D YTA ---- TV S GD L TLT gtpd G P TLSGNVTV P R A RITLPE L PPSAVSLSD DV VVVNRPPE ------ P VPE 527
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 156766050 4475 MLSP G KSIEVSVD V SAPK ------------ MEA D MSI ------- P SMQ G DLKTTDL R IQ A PSAD L EVQA G QV 4527
Cdd:COG2911 528 EEAA G LPLDLDLN V NLGD dvrvrgfgldar LGG D LRL tgtpgga P RLT G EINLVRG R YN A YGQR L TIER G SI 599
TamB
COG2911 Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, ...
854-1456
1.21e-06
Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 442155 [Multi-domain]
Cd Length: 766
Bit Score: 55.43
E-value: 1.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 854 D S VD VS A PKVEA D V S LSSM - Q G D L KATD L SIQPPSADLEVQAGQV D VKL PEG pvp EGA G pkvhlpkvemp SFKMPKVD L K 932
Cdd:COG2911 12 D G VD LE A DRLRL D W S PLAL l R G R L CIDE L ALSASLDGDRLRLDNL D LDA PEG --- ALS G ----------- LLDLVQAT L D 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 933 GPQI D VKG --- PK LDL KGPKAEV T A p D G EV S LP S MEV D VQAQ ---------------- KAKL DG --- AW L EG D LS LA DKD 990
Cdd:COG2911 78 AEGL D LAS sal DD LDL RSGGNRL T L - S G NL S AA S LDG D LDLD apdladlaallpglag SLSG DG lds LS L DA D GT LA QHR 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 991 VTA k D S K FKMPKFKMP --- SFGVSAP G KSIK - ALVDVSAPKVE A DLS L PSMQ G DLKTTD L SIQ ----------- PAST DL 1055
Cdd:COG2911 157 LDL - D A K GEPASLSLA lsg GLDRDDG G TLSR l DFLNTGRWGLA A PAT L SYDD G RVTLGP L CLA gggslclsgtl GGTL DL 235
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1056 KVQADQVDVK L PEGH LP EGA GL K G hlpkvempsfkmpkv A L K G p QV D VK G pkl D L KS P KAEV tap DVEV S L p SVEVDVEA 1135
Cdd:COG2911 236 QLRLKNLPLA L LNPF LP DDL GL S G --------------- T L N G - DA D LS G --- G L AN P QGDA --- SLSL S G - DLTLNDGL 292
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1136 P G AK L DSAR L EGELS LA DKDV T A k D SRFKMPKFKMP S FGA S A P ------- GKSIEASVDVSAP ----------------- 1191
Cdd:COG2911 293 G G LP L GLGD L TLNAR LA NGRL T L - D LTLDGGGLGTL S LSG S V P ladglpp SAPLDGNLRLDNL dlallnpllpgvlerls 371
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1192 - KVEA D VS L ------ P SMQ G D L KTT D LSIQP P SADLEVHAGQVDVKL --------- L EGHVPE G AG - FK G hlpkvqmpsl 1254
Cdd:COG2911 372 g QLNG D LR L sgtlaa P QLN G Q L TLD D GRLKL P ALGVRLTDINLRLRF dgdrltldg L TADSGG G TL t LS G ---------- 441
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1255 kmp K VDL K G PQVEVR gpk L D LKG HKAE V TAHE --- VA VS l PSVEVDMQAP G AK L D G aqldgdlsladk D VT AKDSKFKM P 1331
Cdd:COG2911 442 --- T VDL D G LSWPAD --- L T LKG DNLR V LNPP dyt AT VS - GDLTLTGTPD G PT L S G ------------ N VT VPRARITL P 502
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1332 kfkmpsfgvsapg KSIEAS V D LS APK V EADMSLPSMQGDLKTTD lsiq P PST DL ELQA G Q l DV KL pegpvp E G A GL KGH L 1411
Cdd:COG2911 503 ------------- ELPPSA V S LS DDV V VVNRPPEPVPEEEAAGL ---- P LDL DL NVNL G D - DV RV ------ R G F GL DAR L 558
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 156766050 1412 --- PK L QMPSFKV P ---- KVD L KGPEIDIK G PK L DLK ----------- DP KVEVT A ---- P DV EVSL 1456
Cdd:COG2911 559 ggd LR L TGTPGGA P rltg EIN L VRGRYNAY G QR L TIE rgsitfngppl DP YLDIE A vrtv D DV TAGV 625
AsmA
COG2982 Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall ...
2741-3135
2.03e-06
Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442221 [Multi-domain]
Cd Length: 491
Bit Score: 54.27
E-value: 2.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2741 MP E VD L K GP Q I DVK ----- GP N V D LKGPK A EVT A PD vkmslssmev DVQ A PRAKLDGARLE - G D L SLA D KGMT A K dskfk 2814
Cdd:COG2982 106 VD E IT L D GP V I NLE rdadg RA N W D FLLAA A AAA A DA ---------- EAS A WSLDIGRLEIT d G R L VYD D AASG A D ----- 170
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2815 mpk FKMPSFGVSAP G K S IEASVDV S e LKVEAD G SFPSMQ G DL k TTDIRIQ P PSAQ L EVQA G QVDVK L p E G H V p EG AGL K G 2894
Cdd:COG2982 171 --- LTLDDLNLTLS G P S LDGPFRL S - GSGRLN G QPLTLD G KI - GGLLALG P YPLK L DLRS G DLRLS L - D G T V - DL AGL D G 243
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2895 H L p KVQM PS FK -- MPKVDLKG P Q idvk GPKLD L K G P kae V TA PDVEVS L PSV evdveap RAK L DGAR L E GDLS LADK D VT 2972
Cdd:COG2982 244 Q L - ALSG PS LR dl LALLGVTL P E ---- PGPFS L S G R --- L TA DGDRLR L EDL ------- KGT L GDSD L T GDLS VTGG D RP 308
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2973 A KDSKFKMPKFKMPSFGVS AP GKSIEVSVDVSAPKVE A EVS L PSMQ ---------- GD LK TTDISIEPPS A Q L EVQA G QV 3042
Cdd:COG2982 309 A LTGDLASDRLDLDDLLPA AP AAAAAGAPAAARGLPD A PLD L SALR aldadvrlsa DS LK LGGLPLGDLA A H L TLDD G RL 388
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3043 DL KLPEGHVPE G A g L K G H L pklqmpsfkmp KV D RK G PQID V KG p KL D L K G PKTDVTA PD VEVSQP ----- GMEV D VEAP G 3117
Cdd:COG2982 389 DL DPLSAGLYG G T - L S G S L ----------- TL D AR G DPPR V AL - KL S L S G VDLGPLL PD LAGFDR lsgtl NGDL D LSGT G 455
410 420
....*....|....*....|
gi 156766050 3118 AKLDG -- A R L E G DL SL ADK D 3135
Cdd:COG2982 456 NSVAA ll A S L N G SA SL SLG D 475
AsmA
COG2982 Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall ...
1429-1815
2.50e-06
Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442221 [Multi-domain]
Cd Length: 491
Bit Score: 53.89
E-value: 2.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1429 P EI DIK GP KLD L KDPKVEVTAP D VEVSLPSVEV D V EA PGAK LD G GRLE edms LA D KD L TTK D SKFKM p KFKMPSFGVSAP 1508
Cdd:COG2982 107 D EI TLD GP VIN L ERDADGRANW D FLLAAAAAAA D A EA SAWS LD I GRLE ---- IT D GR L VYD D AASGA - DLTLDDLNLTLS 181
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1509 G K S IEASVDV S A pkv EADVSLPSMQG D L K AT - D L SIQ P PSAD L EVQA G QVDVK L p E G P V S e G AGL K G H L p KVQM PS FK -- 1585
Cdd:COG2982 182 G P S LDGPFRL S G --- SGRLNGQPLTL D G K IG g L L ALG P YPLK L DLRS G DLRLS L - D G T V D - L AGL D G Q L - ALSG PS LR dl 255
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1586 MPKVDLKG P Q idvk GPKLD L K G pkvevtapdv KMSLSSMEVDVQAPRAK L DGAQ L E GDLS LADKAVT A KDSKFKMPKFKM 1665
Cdd:COG2982 256 LALLGVTL P E ---- PGPFS L S G ---------- RLTADGDRLRLEDLKGT L GDSD L T GDLS VTGGDRP A LTGDLASDRLDL 321
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1666 PSFGVS AP GKSIEASVDVSEPKVE A DVS L PSMQ ---------- GD LK TTD L SIQSPS A D L EVQA G QVNVKLPEGP L PE G A 1735
Cdd:COG2982 322 DDLLPA AP AAAAAGAPAAARGLPD A PLD L SALR aldadvrlsa DS LK LGG L PLGDLA A H L TLDD G RLDLDPLSAG L YG G T 401
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1736 g FK G H L pkvqmpslkmp KVALK G PQMD V KG p KL D L K G PKAEVMA PD VEVSLP ----- SVEV D VEAP G AKLDSVR -- L E G D 1808
Cdd:COG2982 402 - LS G S L ----------- TLDAR G DPPR V AL - KL S L S G VDLGPLL PD LAGFDR lsgtl NGDL D LSGT G NSVAALL as L N G S 468
....*..
gi 156766050 1809 L SL ADK D 1815
Cdd:COG2982 469 A SL SLG D 475
AsmA
COG2982 Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall ...
2356-2803
3.12e-06
Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442221 [Multi-domain]
Cd Length: 491
Bit Score: 53.50
E-value: 3.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2356 SMQ GDL ktt D LS VQ P psa DLE V QA G Q V DVKL P E G PVPE gaglkghl P KLQMPSFKM p KVD ---- L K G ---- PQ I DVK GP K 2427
Cdd:COG2982 51 TID GDL --- S LS LF P --- WPG V TL G D V TLSN P D G FGGP -------- P LASAERLEL - DLA llpl L S G elev DE I TLD GP V 115
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2428 LD L KGPKTDVMAP D VEVSQPSVEV D V EA PGAK LD gaw L e G D L SVA D KDVTTK D SRFKI p KFKMPSFGVSAP G K S IEASVD 2507
Cdd:COG2982 116 IN L ERDADGRANW D FLLAAAAAAA D A EA SAWS LD --- I - G R L EIT D GRLVYD D AASGA - DLTLDDLNLTLS G P S LDGPFR 190
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2508 V S A p KVEAD G SLSSMQ G DL k ATD L SIQ P PSAD L EVQA G QVDVK L p E G P V p EG AGL K G H L pkvqmpsfkmpem D L K GP Q L D 2587
Cdd:COG2982 191 L S G - SGRLN G QPLTLD G KI - GGL L ALG P YPLK L DLRS G DLRLS L - D G T V - DL AGL D G Q L ------------- A L S GP S L R 253
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2588 VKGPK L DLKG P KAEVTAPDVEMSLSSMEVDVQAPRAK L DGAR L E GDLS LADKGVT A KDSKFKMPKFKMPSFRVS AP GESI 2667
Cdd:COG2982 254 DLLAL L GVTL P EPGPFSLSGRLTADGDRLRLEDLKGT L GDSD L T GDLS VTGGDRP A LTGDLASDRLDLDDLLPA AP AAAA 333
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2668 ----------- E A LV D V S E L K - VE AD MS L PS mq GD LK TTDISIQPPS A Q L EVQA G QV D VKLPEGHVPE G A g L K G H L --- P 2732
Cdd:COG2982 334 agapaaarglp D A PL D L S A L R a LD AD VR L SA -- DS LK LGGLPLGDLA A H L TLDD G RL D LDPLSAGLYG G T - L S G S L tld A 410
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 156766050 2733 KLQM P SFK mpe VD L KGPQI D VKGPNV DL K G PKAEVTAPDVKMS LS SMEVD V Q A PR A K L D G arl EGD LSL A D 2803
Cdd:COG2982 411 RGDP P RVA --- LK L SLSGV D LGPLLP DL A G FDRLSGTLNGDLD LS GTGNS V A A LL A S L N G --- SAS LSL G D 475
PTZ00121
PTZ00121 MAEBL; Provisional
427-677
9.79e-04
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain]
Cd Length: 2084
Bit Score: 45.90
E-value: 9.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 427 Q A Q E TAV A QR K PR A QPT pgm SREG E GEGLQSLEIGI A RLSLRDTT E GGTQIGPP E IRVRVHDL K TP --- K FAFSTE K EP E 503
Cdd:PTZ00121 1553 K A E E LKK A EE K KK A EEA --- KKAE E DKNMALRKAEE A KKAEEARI E EVMKLYEE E KKMKAEEA K KA eea K IKAEEL K KA E 1629
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 504 R E RRLSTPQRG K RQDASS KA GTGL K G EE VEGA gwmpg REPTTHAE A QG D EGDG EE glqr TRIT EE QD K GREDTEGQIRMP 583
Cdd:PTZ00121 1630 E E KKKVEQLKK K EAEEKK KA EELK K A EE ENKI ----- KAAEEAKK A EE D KKKA EE ---- AKKA EE DE K KAAEALKKEAEE 1700
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 584 KF K IPS L GWSPSKHT K TGR E KATEDT E QGREG E ATATADRREQRRT EE GL KD K E DSDSMTNTT K IQLIHD E KRL K KEQIL 663
Cdd:PTZ00121 1701 AK K AEE L KKKEAEEK K KAE E LKKAEE E NKIKA E EAKKEAEEDKKKA EE AK KD E E EKKKIAHLK K EEEKKA E EIR K EKEAV 1780
250
....*....|....
gi 156766050 664 T E K E VATK D S K FK M 677
Cdd:PTZ00121 1781 I E E E LDEE D E K RR M 1794
PDZ
smart00228 Domain present in PSD-95, Dlg, and ZO-1/2; Also called DHR (Dlg homologous region) or GLGF ...
125-193
1.22e-03
Domain present in PSD-95, Dlg, and ZO-1/2; Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides; others appear to bind internal (non-C-terminal) polypeptides. Different PDZs possess different binding specificities.
Pssm-ID: 214570 [Multi-domain]
Cd Length: 85
Bit Score: 40.83
E-value: 1.22e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 156766050 125 G Y S VT GG G D -- Q G IF V KQ V LKD S S AAK L f N LR E GD QL L S - TTVFF E NIKYED A LKI L QYSEP y KV QFKIR R Q 193
Cdd:smart00228 15 G F S LV GG K D eg G G VV V SS V VPG S P AAK A - G LR V GD VI L E v NGTSV E GLTHLE A VDL L KKAGG - KV TLTVL R G 84
AsmA
COG2982 Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall ...
1759-2145
1.39e-03
Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442221 [Multi-domain]
Cd Length: 491
Bit Score: 45.03
E-value: 1.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1759 PQMDVK GP KLD L KGPKAEVMAP D VEVSLPSVEV D V EA PGAK -- LDSVRLE - G D L SLA D K ---- D V T AK D SKFKM pkfkmp 1831
Cdd:COG2982 107 DEITLD GP VIN L ERDADGRANW D FLLAAAAAAA D A EA SAWS ld IGRLEIT d G R L VYD D A asga D L T LD D LNLTL ------ 180
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1832 sf GVSAPGKSIEA S VDVSAPKVEAEVSLP - SMQGD L KTTD L CIP L P S A DL VVQA - G Q VD M klpegqvpeg AGL K G H L p KV 1909
Cdd:COG2982 181 -- SGPSLDGPFRL S GSGRLNGQPLTLDGK i GGLLA L GPYP L KLD L R S G DL RLSL d G T VD L ---------- AGL D G Q L - AL 247
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1910 DM PS FK -- MPKVDLKG P QTDVKGAKLD L KGPKAEVTAP D V evslpsmevdvqaq K AK L DGAR L E GDLS LADK D MT A KDSK 1987
Cdd:COG2982 248 SG PS LR dl LALLGVTL P EPGPFSLSGR L TADGDRLRLE D L -------------- K GT L GDSD L T GDLS VTGG D RP A LTGD 313
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1988 FKMPKFKMPSFGVS AP GRSIEASVDVPAPKVE A DVS L PSMQ ---------- GD LK TTD L SIQPPS A D L KVQT G QV D VKLP 2057
Cdd:COG2982 314 LASDRLDLDDLLPA AP AAAAAGAPAAARGLPD A PLD L SALR aldadvrlsa DS LK LGG L PLGDLA A H L TLDD G RL D LDPL 393
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2058 EGHVPE G A g L K G H L pkvempslkmp KV D LK G PQVDIKG p KL D L KDPKVEMRV PD VEVSLP ----- SMEV D VQAPRAKLDS 2132
Cdd:COG2982 394 SAGLYG G T - L S G S L ----------- TL D AR G DPPRVAL - KL S L SGVDLGPLL PD LAGFDR lsgtl NGDL D LSGTGNSVAA 460
410
....*....|....*
gi 156766050 2133 -- A H L Q G DLT L ANK D 2145
Cdd:COG2982 461 ll A S L N G SAS L SLG D 475
AsmA
COG2982 Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall ...
3079-3384
2.83e-03
Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442221 [Multi-domain]
Cd Length: 491
Bit Score: 43.87
E-value: 2.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3079 PQ I DVK GP KLD L KGPKTDVTAP D VEVSQPGMEV D V EA PGAK LD GA RLE --- G D L SLA D K ---- D V T AK D SKFKM pkfkmp 3151
Cdd:COG2982 107 DE I TLD GP VIN L ERDADGRANW D FLLAAAAAAA D A EA SAWS LD IG RLE itd G R L VYD D A asga D L T LD D LNLTL ------ 180
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3152 sf GVSAPGKSIEVLVDVSAPKVEAD L SL p SMQ G D L KNTDISI eppsa Q L EVQA G QVDVK L p E G H V l EG AGL K G H L p K L QM 3231
Cdd:COG2982 181 -- SGPSLDGPFRLSGSGRLNGQPLT L DG - KIG G L L ALGPYPL ----- K L DLRS G DLRLS L - D G T V - DL AGL D G Q L - A L SG 249
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3232 PS FK -- MPKVDRKG P Q idik GPKLD L K G p KMDVTAPDVEVSQPS mevdveapg AK L DGAR L E GDLS LADK D VT A KDSKFK 3309
Cdd:COG2982 250 PS LR dl LALLGVTL P E ---- PGPFS L S G - RLTADGDRLRLEDLK --------- GT L GDSD L T GDLS VTGG D RP A LTGDLA 315
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3310 MPKFKMPSYRAS AP GKSIQASVDVSAPKAE A DVS L PSMQ ---------- GD LK TTD L SIQLPSVD L EVQA G QV D VKLPEG 3379
Cdd:COG2982 316 SDRLDLDDLLPA AP AAAAAGAPAAARGLPD A PLD L SALR aldadvrlsa DS LK LGG L PLGDLAAH L TLDD G RL D LDPLSA 395
....*
gi 156766050 3380 HVPE G 3384
Cdd:COG2982 396 GLYG G 400
Name
Accession
Description
Interval
E-value
TamB
COG2911 Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, ...
3328-3832
3.16e-09
Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 442155 [Multi-domain]
Cd Length: 766
Bit Score: 63.91
E-value: 3.16e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3328 QAS VD VS A PKAEA D V S LPSM - Q G D L KTTD L SIQLPSVDLEVQAGQV D VKL PEG HVP --- EGAGLKGHLPKVEMP S FKMPK 3403
Cdd:COG2911 11 DDG VD LE A DRLRL D W S PLAL l R G R L CIDE L ALSASLDGDRLRLDNL D LDA PEG ALS gll DLVQATLDAEGLDLA S SALDD 90
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3404 V DL K S P -- QVDIK G ---- PK LD LKV pka EVTV PD VE v S L PSVEVDV q A PRAKL DG --- AR L EG D LS LA EKDVTA k D S K FK 3474
Cdd:COG2911 91 L DL R S G gn RLTLS G nlsa AS LD GDL --- DLDA PD LA - D L AALLPGL - A GSLSG DG lds LS L DA D GT LA QHRLDL - D A K GE 164
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3475 MPKFKMP --- SFGVSAP G RSIEAS - L DVSAPKVE A DVS LS SMQ G DLKATD L SIQ ----------- PPSA DL EVQAVQVDV 3539
Cdd:COG2911 165 PASLSLA lsg GLDRDDG G TLSRLD f L NTGRWGLA A PAT LS YDD G RVTLGP L CLA gggslclsgtl GGTL DL QLRLKNLPL 244
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3540 E LL EGPV P EGA GL K G hlpkvempslktpkv D L K G p QI D VK G PKLDLK G p K A EVRVPD vevslp SVEVDVQAPKAK L DA G R 3619
Cdd:COG2911 245 A LL NPFL P DDL GL S G --------------- T L N G - DA D LS G GLANPQ G - D A SLSLSG ------ DLTLNDGLGGLP L GL G D 301
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3620 L EGDLS LA DKDV T A k D SKFKMPKFKMP S FRV S A P ------- GKSMEASVDVSAP ------------------ KVEA D VS L 3674
Cdd:COG2911 302 L TLNAR LA NGRL T L - D LTLDGGGLGTL S LSG S V P ladglpp SAPLDGNLRLDNL dlallnpllpgvlerlsg QLNG D LR L 380
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3675 ------ P SMQ G D L KTT D LSIQP P SADLKVQAGQMDVKLPEGQV pegaglkehlp KVEMPSLKMPK -- VD L K G p Q VD IK G P 3746
Cdd:COG2911 381 sgtlaa P QLN G Q L TLD D GRLKL P ALGVRLTDINLRLRFDGDRL ----------- TLDGLTADSGG gt LT L S G - T VD LD G L 448
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3747 K ---- L D LK VSKAE V TA P D --- VE VS ---------- L P SVEVD V QA PRA KLDSAQ L EGDLSLADK DV TAKDSKFK mpkfk 3809
Cdd:COG2911 449 S wpad L T LK GDNLR V LN P P dyt AT VS gdltltgtpd G P TLSGN V TV PRA RITLPE L PPSAVSLSD DV VVVNRPPE ----- 523
570 580
....*....|....*....|...
gi 156766050 3810 m P SFGVS A P G KSIEASVH V SAPK 3832
Cdd:COG2911 524 - P VPEEE A A G LPLDLDLN V NLGD 545
PDZ_PDZD11-like
cd06752 PDZ domain of PDZ domain-containing protein 11, and related domains; PDZ (PSD-95 (Postsynaptic ...
125-181
1.44e-07
PDZ domain of PDZ domain-containing protein 11, and related domains; PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain of PDZD11, and related domains. PDZD11 (also known as ATPase-interacting PDZ protein, plasma membrane calcium ATPase-interacting single-PDZ protein, PMCA-interacting single-PDZ protein, PISP) is involved in the dynamic assembly of apical junctions (AJs). It is recruited by PLEKHA7 to AJs to promote the efficient junctional recruitment and stabilization of nectins, and the efficient early phases of assembly of AJs in epithelial cells. The PDZD11 PDZ domain binds nectin-1 and nectin-3. PDZD11 also binds to a PDZ binding motif located in the C-terminal tail of the human sodium-dependent multivitamin transporter, to the cytoplasmic tail of the Menkes copper ATPase ATP7A, and to the cytoplasmic tail of all plasma membrane Ca2+-ATPase b-splice variants. PDZ domains usually bind in a sequence-specific manner to short peptide sequences located at the C-terminal end of their partner proteins (known as PDZ binding motifs). The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping mediated by beta-strands. This PDZD11-like family domain is a canonical PDZ domain containing six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2), arranged in the order: beta-strands A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F.
Pssm-ID: 467234 [Multi-domain]
Cd Length: 83
Bit Score: 51.93
E-value: 1.44e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 125 G YSVT GG GDQ -- GIF VKQ V LK DS S A AK L f N L R EGDQ L LS TT - V F FE N I KYED A L K I L QYS 181
Cdd:cd06752 14 G FNIR GG KAS gl GIF ISK V IP DS D A HR L - G L K EGDQ I LS VN g V D FE D I EHSE A V K V L KTA 72
TamB
COG2911 Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, ...
3990-4527
2.37e-07
Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 442155 [Multi-domain]
Cd Length: 766
Bit Score: 57.74
E-value: 2.37e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3990 S VD VT A PKVEA D V S LPSM - Q G D L KATD L SVQPPSADLEVQAGQV D VKL PEG PV pe GAS L KGHLPKVQMPSFKMPKVD L KG 4068
Cdd:COG2911 13 G VD LE A DRLRL D W S PLAL l R G R L CIDE L ALSASLDGDRLRLDNL D LDA PEG AL -- SGL L DLVQATLDAEGLDLASSA L DD 90
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 4069 PQIDVK G PK L D L K G P -------- KAEVT APD VK m S L SSMEVDV q A PRAKL DG --- VQ L EG D LS LA DKDVTA k D S K FKMPK 4137
Cdd:COG2911 91 LDLRSG G NR L T L S G N lsaasldg DLDLD APD LA - D L AALLPGL - A GSLSG DG lds LS L DA D GT LA QHRLDL - D A K GEPAS 167
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 4138 FKMPSF G VSAPGKSME ---- ASVDVSELKAK A DVS L PSMQ G DLKTTD L SIQ ----------- SPSA DL EVQAGQVDVK L P 4202
Cdd:COG2911 168 LSLALS G GLDRDDGGT lsrl DFLNTGRWGLA A PAT L SYDD G RVTLGP L CLA gggslclsgtl GGTL DL QLRLKNLPLA L L 247
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 4203 EGP LP KGA GL K G hlpkvqmpclkmpkv A L K G pqvdvkgp KL DL K G PK A D vmt P VVEV SL --- PSMEVDVEAP G AK L DSVR 4279
Cdd:COG2911 248 NPF LP DDL GL S G --------------- T L N G -------- DA DL S G GL A N --- P QGDA SL sls GDLTLNDGLG G LP L GLGD 301
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 4280 L EGDLS LA DKDM T A k D SKFKMPKFKMP S FGV S A P ------- GKSIEAS L DVSA L ------------------ KVEA D VS L 4334
Cdd:COG2911 302 L TLNAR LA NGRL T L - D LTLDGGGLGTL S LSG S V P ladglpp SAPLDGN L RLDN L dlallnpllpgvlerlsg QLNG D LR L 380
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 4335 ------ P SMQ G D L KTTHLSIQP P SADLEVQAGQEDVKLPEG ------- PVHE G A G --- L K G HLP k L QMP S FKVP k VD LKG 4398
Cdd:COG2911 381 sgtlaa P QLN G Q L TLDDGRLKL P ALGVRLTDINLRLRFDGD rltldgl TADS G G G tlt L S G TVD - L DGL S WPAD - LT LKG 458
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 4399 PQID V NV P K l D LKG pkve VT S PN L DVS ---- L P SMEVDIQA P G A KLDSTR L EGDLSLADK DV TAKDSKFK mpkfkm P SFG 4474
Cdd:COG2911 459 DNLR V LN P P - D YTA ---- TV S GD L TLT gtpd G P TLSGNVTV P R A RITLPE L PPSAVSLSD DV VVVNRPPE ------ P VPE 527
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 156766050 4475 MLSP G KSIEVSVD V SAPK ------------ MEA D MSI ------- P SMQ G DLKTTDL R IQ A PSAD L EVQA G QV 4527
Cdd:COG2911 528 EEAA G LPLDLDLN V NLGD dvrvrgfgldar LGG D LRL tgtpgga P RLT G EINLVRG R YN A YGQR L TIER G SI 599
TamB
COG2911 Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, ...
3825-4453
4.48e-07
Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 442155 [Multi-domain]
Cd Length: 766
Bit Score: 56.59
E-value: 4.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3825 S V HVS A PKVEA D V S L psmq GD L KTTD L S I QPHSADLTVQARQVDMKL L EGHV PE e AG L K G H L PK VQ M p SFKMPKV DL KG - 3903
Cdd:COG2911 13 G V DLE A DRLRL D W S P ---- LA L LRGR L C I DELALSASLDGDRLRLDN L DLDA PE - GA L S G L L DL VQ A - TLDAEGL DL AS s 86
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3904 -- PEI D IKGPKLD L K ---------- D PKVEVT APD VE --- VS LP SVEVDVEAP G ak LD GAR L EG D LS LA DKDMTA k D S K F 3968
Cdd:COG2911 87 al DDL D LRSGGNR L T lsgnlsaasl D GDLDLD APD LA dla AL LP GLAGSLSGD G -- LD SLS L DA D GT LA QHRLDL - D A K G 163
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3969 KMPKFKMPSF G VSAPGKSME ---- ASVDVTAPKVE A DVS L PSMQ G DLKATD L SVQ ppsadlev QA G QVDVK lpe G PVPEG 4044
Cdd:COG2911 164 EPASLSLALS G GLDRDDGGT lsrl DFLNTGRWGLA A PAT L SYDD G RVTLGP L CLA -------- GG G SLCLS --- G TLGGT 232
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 4045 AS L KGH L PKVQM --- PS F KMPKVD L K G pqi DVK G p KL DL K G PK A evt A P DVKM SLS --- SMEVDVQAPRAK L DGVQ L EGD 4118
Cdd:COG2911 233 LD L QLR L KNLPL all NP F LPDDLG L S G --- TLN G - DA DL S G GL A --- N P QGDA SLS lsg DLTLNDGLGGLP L GLGD L TLN 305
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 4119 LS LA DKDV T A k D SKFKMPKFKMP S FGV S A P ------- GKSMEASVDVSE L ------------------ KAKA D VS L ---- 4169
Cdd:COG2911 306 AR LA NGRL T L - D LTLDGGGLGTL S LSG S V P ladglpp SAPLDGNLRLDN L dlallnpllpgvlerlsg QLNG D LR L sgtl 384
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 4170 -- P SMQ G D L KTT D LSIQS P SADLEVQAGQVDVKLPEG plpkgaglkghlpkvqmpclkmp KVA L K G PQV D VK G PK L D L K G 4247
Cdd:COG2911 385 aa P QLN G Q L TLD D GRLKL P ALGVRLTDINLRLRFDGD ----------------------- RLT L D G LTA D SG G GT L T L S G 441
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 4248 pkadvmtpvvevslpsmevdveap GAK LD SVRLEG DL S L ADKDMTAKDSKF kmpkfkmpsfgvsapgksie ASLD VS A - L 4326
Cdd:COG2911 442 ------------------------ TVD LD GLSWPA DL T L KGDNLRVLNPPD -------------------- YTAT VS G d L 477
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 4327 KVEADVSL P SMQ G DLKTTHLS I QP P SADLEVQAGQE DV klpegp V HEGA glkghlpklqm P SFK VP KVDLK G PQI D VNV p 4406
Cdd:COG2911 478 TLTGTPDG P TLS G NVTVPRAR I TL P ELPPSAVSLSD DV ------ V VVNR ----------- P PEP VP EEEAA G LPL D LDL - 539
650 660 670 680
....*....|....*....|....*....|....*....|....*..
gi 156766050 4407 KLD L k G PK V E V TSPN LD VS L psm EV D IQAP G AKLDST RL E G DLS L AD 4453
Cdd:COG2911 540 NVN L - G DD V R V RGFG LD AR L --- GG D LRLT G TPGGAP RL T G EIN L VR 582
TamB
COG2911 Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, ...
854-1456
1.21e-06
Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 442155 [Multi-domain]
Cd Length: 766
Bit Score: 55.43
E-value: 1.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 854 D S VD VS A PKVEA D V S LSSM - Q G D L KATD L SIQPPSADLEVQAGQV D VKL PEG pvp EGA G pkvhlpkvemp SFKMPKVD L K 932
Cdd:COG2911 12 D G VD LE A DRLRL D W S PLAL l R G R L CIDE L ALSASLDGDRLRLDNL D LDA PEG --- ALS G ----------- LLDLVQAT L D 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 933 GPQI D VKG --- PK LDL KGPKAEV T A p D G EV S LP S MEV D VQAQ ---------------- KAKL DG --- AW L EG D LS LA DKD 990
Cdd:COG2911 78 AEGL D LAS sal DD LDL RSGGNRL T L - S G NL S AA S LDG D LDLD apdladlaallpglag SLSG DG lds LS L DA D GT LA QHR 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 991 VTA k D S K FKMPKFKMP --- SFGVSAP G KSIK - ALVDVSAPKVE A DLS L PSMQ G DLKTTD L SIQ ----------- PAST DL 1055
Cdd:COG2911 157 LDL - D A K GEPASLSLA lsg GLDRDDG G TLSR l DFLNTGRWGLA A PAT L SYDD G RVTLGP L CLA gggslclsgtl GGTL DL 235
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1056 KVQADQVDVK L PEGH LP EGA GL K G hlpkvempsfkmpkv A L K G p QV D VK G pkl D L KS P KAEV tap DVEV S L p SVEVDVEA 1135
Cdd:COG2911 236 QLRLKNLPLA L LNPF LP DDL GL S G --------------- T L N G - DA D LS G --- G L AN P QGDA --- SLSL S G - DLTLNDGL 292
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1136 P G AK L DSAR L EGELS LA DKDV T A k D SRFKMPKFKMP S FGA S A P ------- GKSIEASVDVSAP ----------------- 1191
Cdd:COG2911 293 G G LP L GLGD L TLNAR LA NGRL T L - D LTLDGGGLGTL S LSG S V P ladglpp SAPLDGNLRLDNL dlallnpllpgvlerls 371
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1192 - KVEA D VS L ------ P SMQ G D L KTT D LSIQP P SADLEVHAGQVDVKL --------- L EGHVPE G AG - FK G hlpkvqmpsl 1254
Cdd:COG2911 372 g QLNG D LR L sgtlaa P QLN G Q L TLD D GRLKL P ALGVRLTDINLRLRF dgdrltldg L TADSGG G TL t LS G ---------- 441
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1255 kmp K VDL K G PQVEVR gpk L D LKG HKAE V TAHE --- VA VS l PSVEVDMQAP G AK L D G aqldgdlsladk D VT AKDSKFKM P 1331
Cdd:COG2911 442 --- T VDL D G LSWPAD --- L T LKG DNLR V LNPP dyt AT VS - GDLTLTGTPD G PT L S G ------------ N VT VPRARITL P 502
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1332 kfkmpsfgvsapg KSIEAS V D LS APK V EADMSLPSMQGDLKTTD lsiq P PST DL ELQA G Q l DV KL pegpvp E G A GL KGH L 1411
Cdd:COG2911 503 ------------- ELPPSA V S LS DDV V VVNRPPEPVPEEEAAGL ---- P LDL DL NVNL G D - DV RV ------ R G F GL DAR L 558
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 156766050 1412 --- PK L QMPSFKV P ---- KVD L KGPEIDIK G PK L DLK ----------- DP KVEVT A ---- P DV EVSL 1456
Cdd:COG2911 559 ggd LR L TGTPGGA P rltg EIN L VRGRYNAY G QR L TIE rgsitfngppl DP YLDIE A vrtv D DV TAGV 625
AsmA
COG2982 Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall ...
1036-1468
1.31e-06
Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442221 [Multi-domain]
Cd Length: 491
Bit Score: 55.04
E-value: 1.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1036 SMQ GDL ktt D LS IQ P A std LK V QADQ V DVKL P E G HLPE gaglkghl P KVEMPSFKM p KV A ---- L K G ---- PQVDVK GP K 1107
Cdd:COG2982 51 TID GDL --- S LS LF P W --- PG V TLGD V TLSN P D G FGGP -------- P LASAERLEL - DL A llpl L S G elev DEITLD GP V 115
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1108 LD L KSPKAEVTAP D VEVSLPSVEV D V EA PGAK LD SA RLE --- G E L SLA D K ---- D V T AK D SRFKM pkf KM PS FGASAP gk 1180
Cdd:COG2982 116 IN L ERDADGRANW D FLLAAAAAAA D A EA SAWS LD IG RLE itd G R L VYD D A asga D L T LD D LNLTL --- SG PS LDGPFR -- 190
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1181 s IEA S VDVSAPKVEA D VSL psmqgdlk TTD L SIQ P PSAD L EVHA G QVDVK L l E G H V p EG AG FK G H L p KVQM PSL K -- MPK 1258
Cdd:COG2982 191 - LSG S GRLNGQPLTL D GKI -------- GGL L ALG P YPLK L DLRS G DLRLS L - D G T V - DL AG LD G Q L - ALSG PSL R dl LAL 258
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1259 VDLKG P Q vevr GPKLD L K G H kae V TA HEVAVS L PSVE vdmqapg AK L DGAQ L D GDLS LADK D VT A KDSKFKMPKFKMPSF 1338
Cdd:COG2982 259 LGVTL P E ---- PGPFS L S G R --- L TA DGDRLR L EDLK ------- GT L GDSD L T GDLS VTGG D RP A LTGDLASDRLDLDDL 324
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1339 GVS AP GKSIEAS ----------- V DLSA - PKVE AD MS L PS mq GD LK TTD L SIQPPSTD L E L QA G Q LD VKLPEGPVPE G A g 1406
Cdd:COG2982 325 LPA AP AAAAAGA paaarglpdap L DLSA l RALD AD VR L SA -- DS LK LGG L PLGDLAAH L T L DD G R LD LDPLSAGLYG G T - 401
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 156766050 1407 L K G H L pklqmpsfkvp KV D LK G PEIDIKG p KL D L KDPKVEVTA PD VEVSLP ----- SVEV D VEAP G A 1468
Cdd:COG2982 402 L S G S L ----------- TL D AR G DPPRVAL - KL S L SGVDLGPLL PD LAGFDR lsgtl NGDL D LSGT G N 456
AsmA
COG2982 Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall ...
2741-3135
2.03e-06
Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442221 [Multi-domain]
Cd Length: 491
Bit Score: 54.27
E-value: 2.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2741 MP E VD L K GP Q I DVK ----- GP N V D LKGPK A EVT A PD vkmslssmev DVQ A PRAKLDGARLE - G D L SLA D KGMT A K dskfk 2814
Cdd:COG2982 106 VD E IT L D GP V I NLE rdadg RA N W D FLLAA A AAA A DA ---------- EAS A WSLDIGRLEIT d G R L VYD D AASG A D ----- 170
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2815 mpk FKMPSFGVSAP G K S IEASVDV S e LKVEAD G SFPSMQ G DL k TTDIRIQ P PSAQ L EVQA G QVDVK L p E G H V p EG AGL K G 2894
Cdd:COG2982 171 --- LTLDDLNLTLS G P S LDGPFRL S - GSGRLN G QPLTLD G KI - GGLLALG P YPLK L DLRS G DLRLS L - D G T V - DL AGL D G 243
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2895 H L p KVQM PS FK -- MPKVDLKG P Q idvk GPKLD L K G P kae V TA PDVEVS L PSV evdveap RAK L DGAR L E GDLS LADK D VT 2972
Cdd:COG2982 244 Q L - ALSG PS LR dl LALLGVTL P E ---- PGPFS L S G R --- L TA DGDRLR L EDL ------- KGT L GDSD L T GDLS VTGG D RP 308
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2973 A KDSKFKMPKFKMPSFGVS AP GKSIEVSVDVSAPKVE A EVS L PSMQ ---------- GD LK TTDISIEPPS A Q L EVQA G QV 3042
Cdd:COG2982 309 A LTGDLASDRLDLDDLLPA AP AAAAAGAPAAARGLPD A PLD L SALR aldadvrlsa DS LK LGGLPLGDLA A H L TLDD G RL 388
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3043 DL KLPEGHVPE G A g L K G H L pklqmpsfkmp KV D RK G PQID V KG p KL D L K G PKTDVTA PD VEVSQP ----- GMEV D VEAP G 3117
Cdd:COG2982 389 DL DPLSAGLYG G T - L S G S L ----------- TL D AR G DPPR V AL - KL S L S G VDLGPLL PD LAGFDR lsgtl NGDL D LSGT G 455
410 420
....*....|....*....|
gi 156766050 3118 AKLDG -- A R L E G DL SL ADK D 3135
Cdd:COG2982 456 NSVAA ll A S L N G SA SL SLG D 475
AsmA
COG2982 Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall ...
1429-1815
2.50e-06
Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442221 [Multi-domain]
Cd Length: 491
Bit Score: 53.89
E-value: 2.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1429 P EI DIK GP KLD L KDPKVEVTAP D VEVSLPSVEV D V EA PGAK LD G GRLE edms LA D KD L TTK D SKFKM p KFKMPSFGVSAP 1508
Cdd:COG2982 107 D EI TLD GP VIN L ERDADGRANW D FLLAAAAAAA D A EA SAWS LD I GRLE ---- IT D GR L VYD D AASGA - DLTLDDLNLTLS 181
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1509 G K S IEASVDV S A pkv EADVSLPSMQG D L K AT - D L SIQ P PSAD L EVQA G QVDVK L p E G P V S e G AGL K G H L p KVQM PS FK -- 1585
Cdd:COG2982 182 G P S LDGPFRL S G --- SGRLNGQPLTL D G K IG g L L ALG P YPLK L DLRS G DLRLS L - D G T V D - L AGL D G Q L - ALSG PS LR dl 255
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1586 MPKVDLKG P Q idvk GPKLD L K G pkvevtapdv KMSLSSMEVDVQAPRAK L DGAQ L E GDLS LADKAVT A KDSKFKMPKFKM 1665
Cdd:COG2982 256 LALLGVTL P E ---- PGPFS L S G ---------- RLTADGDRLRLEDLKGT L GDSD L T GDLS VTGGDRP A LTGDLASDRLDL 321
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1666 PSFGVS AP GKSIEASVDVSEPKVE A DVS L PSMQ ---------- GD LK TTD L SIQSPS A D L EVQA G QVNVKLPEGP L PE G A 1735
Cdd:COG2982 322 DDLLPA AP AAAAAGAPAAARGLPD A PLD L SALR aldadvrlsa DS LK LGG L PLGDLA A H L TLDD G RLDLDPLSAG L YG G T 401
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1736 g FK G H L pkvqmpslkmp KVALK G PQMD V KG p KL D L K G PKAEVMA PD VEVSLP ----- SVEV D VEAP G AKLDSVR -- L E G D 1808
Cdd:COG2982 402 - LS G S L ----------- TLDAR G DPPR V AL - KL S L S G VDLGPLL PD LAGFDR lsgtl NGDL D LSGT G NSVAALL as L N G S 468
....*..
gi 156766050 1809 L SL ADK D 1815
Cdd:COG2982 469 A SL SLG D 475
AsmA
COG2982 Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall ...
871-1320
2.65e-06
Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442221 [Multi-domain]
Cd Length: 491
Bit Score: 53.89
E-value: 2.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 871 SMQ GDL kat D LS IQ P psa DLE V QA G Q V DVKL P E G P vpe G AG P KVHLPKV E M p SFKMPKV d L K G ---- PQ I DVK GP KLD L k 946
Cdd:COG2982 51 TID GDL --- S LS LF P --- WPG V TL G D V TLSN P D G F --- G GP P LASAERL E L - DLALLPL - L S G elev DE I TLD GP VIN L - 118
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 947 gpkae VTAP DG EVSLPSMEVDVQ A QKAKLDG AW LE -- G D L SLA D KDVTAK D SKFKM p KFKMPSFGVSAP G K S IKALVDV S 1024
Cdd:COG2982 119 ----- ERDA DG RANWDFLLAAAA A AADAEAS AW SL di G R L EIT D GRLVYD D AASGA - DLTLDDLNLTLS G P S LDGPFRL S 192
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1025 A pkv EAD L SLPSMQG D L K TT - D L SIQ P ASTD L KVQADQVDVK L p E G HL p EG AGL K G H L pkv EMPSFKMPKVALKGPQVDV 1103
Cdd:COG2982 193 G --- SGR L NGQPLTL D G K IG g L L ALG P YPLK L DLRSGDLRLS L - D G TV - DL AGL D G Q L --- ALSGPSLRDLLALLGVTLP 264
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1104 KGPKLD L K spk AEV TA PDVEVS L PSVE vdveapg AK L DSAR L E G E LS LADK D VT A KDSRFKMPKFKMPSFGAS AP GKSIE 1183
Cdd:COG2982 265 EPGPFS L S --- GRL TA DGDRLR L EDLK ------- GT L GDSD L T G D LS VTGG D RP A LTGDLASDRLDLDDLLPA AP AAAAA 334
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1184 ASVDVSAPKVE A DVS L PSMQ ---------- GD LK TTD L SIQPPS A D L EVHA G QV D VKL L EGHVPE G A g FK G H L pkvqmps 1253
Cdd:COG2982 335 GAPAAARGLPD A PLD L SALR aldadvrlsa DS LK LGG L PLGDLA A H L TLDD G RL D LDP L SAGLYG G T - LS G S L ------- 406
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 156766050 1254 lkmp KV D LK G PQVE V RG p KL D L K G HKAEVTAHEV A VSLP ----- SVEV D MQAP G AKLDG -- A Q L D G DL SL ADK D 1320
Cdd:COG2982 407 ---- TL D AR G DPPR V AL - KL S L S G VDLGPLLPDL A GFDR lsgtl NGDL D LSGT G NSVAA ll A S L N G SA SL SLG D 475
AsmA
COG2982 Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall ...
2356-2803
3.12e-06
Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442221 [Multi-domain]
Cd Length: 491
Bit Score: 53.50
E-value: 3.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2356 SMQ GDL ktt D LS VQ P psa DLE V QA G Q V DVKL P E G PVPE gaglkghl P KLQMPSFKM p KVD ---- L K G ---- PQ I DVK GP K 2427
Cdd:COG2982 51 TID GDL --- S LS LF P --- WPG V TL G D V TLSN P D G FGGP -------- P LASAERLEL - DLA llpl L S G elev DE I TLD GP V 115
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2428 LD L KGPKTDVMAP D VEVSQPSVEV D V EA PGAK LD gaw L e G D L SVA D KDVTTK D SRFKI p KFKMPSFGVSAP G K S IEASVD 2507
Cdd:COG2982 116 IN L ERDADGRANW D FLLAAAAAAA D A EA SAWS LD --- I - G R L EIT D GRLVYD D AASGA - DLTLDDLNLTLS G P S LDGPFR 190
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2508 V S A p KVEAD G SLSSMQ G DL k ATD L SIQ P PSAD L EVQA G QVDVK L p E G P V p EG AGL K G H L pkvqmpsfkmpem D L K GP Q L D 2587
Cdd:COG2982 191 L S G - SGRLN G QPLTLD G KI - GGL L ALG P YPLK L DLRS G DLRLS L - D G T V - DL AGL D G Q L ------------- A L S GP S L R 253
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2588 VKGPK L DLKG P KAEVTAPDVEMSLSSMEVDVQAPRAK L DGAR L E GDLS LADKGVT A KDSKFKMPKFKMPSFRVS AP GESI 2667
Cdd:COG2982 254 DLLAL L GVTL P EPGPFSLSGRLTADGDRLRLEDLKGT L GDSD L T GDLS VTGGDRP A LTGDLASDRLDLDDLLPA AP AAAA 333
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2668 ----------- E A LV D V S E L K - VE AD MS L PS mq GD LK TTDISIQPPS A Q L EVQA G QV D VKLPEGHVPE G A g L K G H L --- P 2732
Cdd:COG2982 334 agapaaarglp D A PL D L S A L R a LD AD VR L SA -- DS LK LGGLPLGDLA A H L TLDD G RL D LDPLSAGLYG G T - L S G S L tld A 410
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 156766050 2733 KLQM P SFK mpe VD L KGPQI D VKGPNV DL K G PKAEVTAPDVKMS LS SMEVD V Q A PR A K L D G arl EGD LSL A D 2803
Cdd:COG2982 411 RGDP P RVA --- LK L SLSGV D LGPLLP DL A G FDRLSGTLNGDLD LS GTGNS V A A LL A S L N G --- SAS LSL G D 475
TamB
COG2911 Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, ...
1021-1607
4.40e-06
Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 442155 [Multi-domain]
Cd Length: 766
Bit Score: 53.51
E-value: 4.40e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1021 VD VS A PKVEA D L S LPSM - Q G D L KTTD L SIQPASTDLKVQA D QV D VKL PEG H L pe GAG L KGHLPKVEMPSFKMPKV AL KGP 1099
Cdd:COG2911 14 VD LE A DRLRL D W S PLAL l R G R L CIDE L ALSASLDGDRLRL D NL D LDA PEG A L -- SGL L DLVQATLDAEGLDLASS AL DDL 91
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1100 QVDVK G PK L D L K -------- SPKAEVT APD VE --- VS LP SVEVDVEAP G ak LDS AR L EGELS LA DKDVTA k D SRFKMPKF 1168
Cdd:COG2911 92 DLRSG G NR L T L S gnlsaasl DGDLDLD APD LA dla AL LP GLAGSLSGD G -- LDS LS L DADGT LA QHRLDL - D AKGEPASL 168
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1169 KMPSF G ASAPGKSIE ---- ASVDVSAPKVE A DVS L PSMQ G DLKTTD L SIQ ----------- PPSA DL EVHAGQVDVK LL E 1233
Cdd:COG2911 169 SLALS G GLDRDDGGT lsrl DFLNTGRWGLA A PAT L SYDD G RVTLGP L CLA gggslclsgtl GGTL DL QLRLKNLPLA LL N 248
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1234 GHV P EGA G FK G hlpkvqmpslkmpkv D L K G p QVEVR G PKLDLK G h K A EVTAHE vavslp SVEVDMQAP G AK L DGAQ L DGD 1313
Cdd:COG2911 249 PFL P DDL G LS G --------------- T L N G - DADLS G GLANPQ G - D A SLSLSG ------ DLTLNDGLG G LP L GLGD L TLN 305
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1314 LS LA DKDV T A kdskfkmpkfkmpsfgvsapgksi EASV D L sapkve ADMSLP S MQ G DLKTT D LSIQPPST D LE L QAGQ LD 1393
Cdd:COG2911 306 AR LA NGRL T L ------------------------ DLTL D G ------ GGLGTL S LS G SVPLA D GLPPSAPL D GN L RLDN LD 355
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1394 VK L PEGPV P E - GAG L K G H L pklqmpsfkvp KV DL K gpeid IK G P kld L KD P KV -- EV T AP D VEVS LP SVE V DVEAPGAK - 1469
Cdd:COG2911 356 LA L LNPLL P G v LER L S G Q L ----------- NG DL R ----- LS G T --- L AA P QL ng QL T LD D GRLK LP ALG V RLTDINLR l 416
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1470 - L DG G RL EE D MSL AD K --------- DLTTKDSKFKMP - KF K MPSFG V SA P G ksi EASVD VS AP - KVEADVSL P SMQ G DLK 1537
Cdd:COG2911 417 r F DG D RL TL D GLT AD S gggtltlsg TVDLDGLSWPAD l TL K GDNLR V LN P P --- DYTAT VS GD l TLTGTPDG P TLS G NVT 493
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 156766050 1538 ATDLS I QP P SADLEVQAGQV DV KLPEG P VSE gaglkgh L P KVQMPSFKM p KV DL K --- G PQID V K G PK LD LKG 1607
Cdd:COG2911 494 VPRAR I TL P ELPPSAVSLSD DV VVVNR P PEP ------- V P EEEAAGLPL - DL DL N vnl G DDVR V R G FG LD ARL 558
PDZ_canonical
cd00136 canonical PDZ domain; Canonical PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs ...
112-179
6.08e-06
canonical PDZ domain; Canonical PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain. PDZ domains usually bind to short specific peptide sequences located at the C-terminal end of their partner proteins known as PDZ binding motifs. These domains can also interact with internal peptide motifs and certain lipids, and can take part in a head-to-tail oligomerization with other PDZ domains. The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping mediated by beta-strands. The canonical PDZ domain contains six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2), arranged in the order: beta-strands A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F.
Pssm-ID: 467153 [Multi-domain]
Cd Length: 81
Bit Score: 47.54
E-value: 6.08e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 156766050 112 E VTL KTEVEA G a S G Y S VT GG -- G DQ GIFV KQ V LKDSS AA KLFN LR E GD QL L ST - T V FF E NIKY E D A LKI L Q 179
Cdd:cd00136 1 T VTL EKDPGG G - L G F S IR GG kd G GG GIFV SR V EPGGP AA RDGR LR V GD RI L EV n G V SL E GLTH E E A VEL L K 70
PDZ_RapGEF2_RapGEF6-like
cd06755 PDZ domain of Rap guanine nucleotide exchange factor 2 and Rap guanine nucleotide exchange ...
125-179
9.34e-06
PDZ domain of Rap guanine nucleotide exchange factor 2 and Rap guanine nucleotide exchange factor 6, and related domains; PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain of Rap guanine nucleotide exchange factor 2 (RapGEF2, also named RA-GEF-1, PDZ-GEF1, CNrasGEF and nRapGEP) and Rap guanine nucleotide exchange factor 6 (RapGEF6, also named RA-GEF-2 and PDZ-GEF2). RapGEF2 and RapGEF6 constitute a subfamily of guanine nucleotide exchange factors (GEFs) for RAP small GTPases that is characterized by the possession of the PDZ and Ras/Rap-associating domains. They activate Rap small GTPases, by catalyzing the release of GDP from the inactive GDP-bound forms, thereby accelerating GTP loading to yield the active GTP-bound forms. The PDZ domain of RapGEF6 (also known as PDZ-GEF2) binds junctional adhesion molecule A (JAM-A). PDZ domains usually bind in a sequence-specific manner to short peptide sequences located at the C-terminal end of their partner proteins (known as PDZ binding motifs). The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping mediated by beta-strands. This RapGEF2 and RapGEF6 family domain is a canonical PDZ domain containing six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2), arranged in the order: beta-strands A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F.
Pssm-ID: 467237 [Multi-domain]
Cd Length: 83
Bit Score: 46.87
E-value: 9.34e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 156766050 125 GY S VT GG GDQ -- GIFV KQ V L K D S S AA KL f N L RE GDQ L L STT - VF FENI KYED AL K IL Q 179
Cdd:cd06755 15 HF S LL GG SEK gf GIFV SK V E K G S K AA EA - G L KR GDQ I L EVN g QN FENI TLKK AL E IL R 71
PDZ1_MUPP1-like
cd06689 PDZ domain 1 of multi-PDZ-domain protein 1 (MUPP1) and PATJ (protein-associated tight junction) ...
120-179
1.14e-05
PDZ domain 1 of multi-PDZ-domain protein 1 (MUPP1) and PATJ (protein-associated tight junction), and related domains; PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain 1 of MUPP1 and PATJ, and related domains. MUPP1 and PATJ serve as scaffolding proteins linking different proteins and protein complexes involved in the organization of tight junctions and epithelial polarity. MUPP1 contains an L27 (Lin-2 and Lin-7 binding) domain and 13 PDZ domains. PATJ (also known as INAD-like) contains an L27 domain and ten PDZ domains. MUPP1 and PATJ share several binding partners, including junctional adhesion molecules (JAM), zonula occludens (ZO)-3, Pals1 (protein associated with Lin-7), Par (partitioning defective)-6 proteins, and nectins (adherence junction adhesion molecules). PATJ lacks 3 PDZ domains seen in MUPP1: PDZ6, 9, and 13; consequently, MUPP1 PDZ7 and 8 align with PATJ PDZ6 and 7; and MUPP1 PDZ domains 10-12 align with PATJ PDZ domains 8-10. PDZ domains usually bind in a sequence-specific manner to short peptide sequences located at the C-terminal end of their partner proteins (known as PDZ binding motifs). The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping mediated by beta-strands. This MUPP1-like family PDZ1 domain is a canonical PDZ domain containing six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2), arranged in the order: beta-strands A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F.
Pssm-ID: 467176 [Multi-domain]
Cd Length: 102
Bit Score: 47.24
E-value: 1.14e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 156766050 120 E A G AS G Y SV T G ----- G G DQ GIFV KQVLKD S S AA KLFN L R E G DQ L L ST -- TVFFEN I KYED A LK ILQ 179
Cdd:cd06689 24 E S G GL G F SV V G lksen R G EL GIFV QEIQPG S V AA RDGR L K E N DQ I L AI ng QPLDQS I SHQQ A IA ILQ 90
AsmA
COG2982 Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall ...
700-1155
1.51e-05
Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442221 [Multi-domain]
Cd Length: 491
Bit Score: 51.58
E-value: 1.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 700 V SA PKV E A D VS LL S - MQ G D L KTTDLSVQT P SAD LE VQ - DG QVDVKLPEGPLPEG A S lkghl PKVQRP SL KMPKVDLKGPK 777
Cdd:COG2982 85 A SA ERL E L D LA LL P l LS G E L EVDEITLDG P VIN LE RD a DG RANWDFLLAAAAAA A D ----- AEASAW SL DIGRLEITDGR 159
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 778 L DLKGPKAEVT apdvk MS L SSMEVDVQA P R ak LDG A - RL E G DLS L ADKEV T A k D S K FKMP k FKMPSFGVSAPGK S MEDSV 856
Cdd:COG2982 160 L VYDDAASGAD ----- LT L DDLNLTLSG P S -- LDG P f RL S G SGR L NGQPL T L - D G K IGGL - LALGPYPLKLDLR S GDLRL 230
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 857 DVS apkve AD V S L SSMQ G D L KAT dlsiqpp SAD L EVQAGQVD V K LPE gpvpegagpkvhlpkvempsfkmpkvdlkgpqi 936
Cdd:COG2982 231 SLD ----- GT V D L AGLD G Q L ALS ------- GPS L RDLLALLG V T LPE --------------------------------- 265
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 937 dvk GPKLD L K G P kae V TA PDGEVS L PSM evdvqaq K AK L DGAW L E GDLS LADK D VT A KDSKFKMPKFKMPSFGVS AP GKS 1016
Cdd:COG2982 266 --- PGPFS L S G R --- L TA DGDRLR L EDL ------- K GT L GDSD L T GDLS VTGG D RP A LTGDLASDRLDLDDLLPA AP AAA 332
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1017 IKALVDVSAPKVE A D L S L PSMQ ---------- GD LK TTD L SIQPASTD L KVQADQV D VKLPEGH L PE G A g L K G H L pkvem 1086
Cdd:COG2982 333 AAGAPAAARGLPD A P L D L SALR aldadvrlsa DS LK LGG L PLGDLAAH L TLDDGRL D LDPLSAG L YG G T - L S G S L ----- 406
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 156766050 1087 psfkmp KVALK G PQVD V KG p KL D L KSPKAEVTA PD VEVSLP ----- SVEV D VEAP G AKLDS -- A R L E G EL SL ADK D 1155
Cdd:COG2982 407 ------ TLDAR G DPPR V AL - KL S L SGVDLGPLL PD LAGFDR lsgtl NGDL D LSGT G NSVAA ll A S L N G SA SL SLG D 475
TamB
COG2911 Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, ...
2505-3044
1.54e-05
Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 442155 [Multi-domain]
Cd Length: 766
Bit Score: 51.58
E-value: 1.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2505 S VD VS A PKVEA D G S LSSM - Q G D L KATD L SIQPPSADLEVQAGQV D VKL PEG PV pe GAG L KGHLPKVQMPSFKMPEMD L KG 2583
Cdd:COG2911 13 G VD LE A DRLRL D W S PLAL l R G R L CIDE L ALSASLDGDRLRLDNL D LDA PEG AL -- SGL L DLVQATLDAEGLDLASSA L DD 90
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2584 PQ L DVK G PK L D L K G P -------- KAEVT APD VE m S L SSMEVDV q A PRAKL DG AR leg D LSL ADK G VT A KDS kfkmpkfkm 2655
Cdd:COG2911 91 LD L RSG G NR L T L S G N lsaasldg DLDLD APD LA - D L AALLPGL - A GSLSG DG LD --- S LSL DAD G TL A QHR --------- 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2656 ps FRVS A P GE SIEALVDV S - E L KVEADMS L PSMQ g D L K T TDISIQP P s A Q L EVQA G Q V DV klp EGHVPE G A G --- L K G H L 2731
Cdd:COG2911 157 -- LDLD A K GE PASLSLAL S g G L DRDDGGT L SRLD - F L N T GRWGLAA P - A T L SYDD G R V TL --- GPLCLA G G G slc L S G T L 229
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2732 PKLQMPSFKMPEVD L K ------ GPQIDVK G P --- NV DL K G PK A evt A P DVKM SLS --- SMEVDVQAPRAK L DGAR L EGDL 2799
Cdd:COG2911 230 GGTLDLQLRLKNLP L A llnpfl PDDLGLS G T lng DA DL S G GL A --- N P QGDA SLS lsg DLTLNDGLGGLP L GLGD L TLNA 306
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2800 S LA DKGM T A k D SKFKMPKFKMP S FGV S A P ------- GKSIEASVDVSE L ------------------ KVEA D GSF ----- 2849
Cdd:COG2911 307 R LA NGRL T L - D LTLDGGGLGTL S LSG S V P ladglpp SAPLDGNLRLDN L dlallnpllpgvlerlsg QLNG D LRL sgtla 385
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2850 - P SMQ G D L KTT D I R IQP P SAQLEVQAGQVDVKLPE --------- GHVPE G AG - L K G hlp K V QMPSFKM P - KVD LKG ---- 2913
Cdd:COG2911 386 a P QLN G Q L TLD D G R LKL P ALGVRLTDINLRLRFDG drltldglt ADSGG G TL t L S G --- T V DLDGLSW P a DLT LKG dnlr 462
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2914 ------------ PQIDVK G P -- KLD L K G ---- P K A EV T A P DVEV S LP S VEV DV eaprakldga RLEGDLSLADKDVT A KD 2975
Cdd:COG2911 463 vlnppdytatvs GDLTLT G T pd GPT L S G nvtv P R A RI T L P ELPP S AV S LSD DV ---------- VVVNRPPEPVPEEE A AG 532
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 156766050 2976 SKFKM pkfkmp SFG V SAPGK sievs V D V SAPKVE A E vslps MQ GDL KT T DISIEP P SA -- QLEVQA G QVDL 3044
Cdd:COG2911 533 LPLDL ------ DLN V NLGDD ----- V R V RGFGLD A R ----- LG GDL RL T GTPGGA P RL tg EINLVR G RYNA 587
TamB
COG2911 Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, ...
3000-3615
1.54e-05
Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 442155 [Multi-domain]
Cd Length: 766
Bit Score: 51.58
E-value: 1.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3000 S VD VS A PKVEAEV S L psmq GD L KTTDIS I EPPSAQLEVQAGQVD L KLPEGHV PEGA g L K G H L P ---- K L QMPSFKMPKVD 3075
Cdd:COG2911 13 G VD LE A DRLRLDW S P ---- LA L LRGRLC I DELALSASLDGDRLR L DNLDLDA PEGA - L S G L L D lvqa T L DAEGLDLASSA 87
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3076 RKGPQIDVK G PK L D L K G PKT -------- D VT APD VEVSQ --- PG MEVDVEAP G ak LD GAR L EG D LS LA DKDVTAK dskfk 3144
Cdd:COG2911 88 LDDLDLRSG G NR L T L S G NLS aasldgdl D LD APD LADLA all PG LAGSLSGD G -- LD SLS L DA D GT LA QHRLDLD ----- 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3145 m P K FKMP S FGVSAP G K sievl V D VSAPKVEAD L S lpsmqg D L KNTDISIEP P s A Q L EVQA G Q V DV klp EGHV L E G A G --- 3221
Cdd:COG2911 161 - A K GEPA S LSLALS G G ----- L D RDDGGTLSR L D ------ F L NTGRWGLAA P - A T L SYDD G R V TL --- GPLC L A G G G slc 224
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3222 ---------- L KGH L PK L QMPSFKMPKV D RK G PQIDIK G p KL DL K G pkm DVTA P DVEV S --- QPSMEVDVEAP G AK L DGA 3288
Cdd:COG2911 225 lsgtlggtld L QLR L KN L PLALLNPFLP D DL G LSGTLN G - DA DL S G --- GLAN P QGDA S lsl SGDLTLNDGLG G LP L GLG 300
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3289 R L EGDLS LA DKDV T A k D SKFKMPKFKMP S YRA S A P ------- GKSIQASVDVSAP ------------------ KAEA D VS 3343
Cdd:COG2911 301 D L TLNAR LA NGRL T L - D LTLDGGGLGTL S LSG S V P ladglpp SAPLDGNLRLDNL dlallnpllpgvlerlsg QLNG D LR 379
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3344 L ------ P SMQ G D L KTT D LSIQ LP SVDLEVQAGQVDVKLPE --------- GHVPE G ---------------- A G L KGHLP 3392
Cdd:COG2911 380 L sgtlaa P QLN G Q L TLD D GRLK LP ALGVRLTDINLRLRFDG drltldglt ADSGG G tltlsgtvdldglswp A D L TLKGD 459
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3393 KVEMPSFKMPKVDL k S PQVDIK G P ------ KLDLK VP K A EV T V P DVEV S LP S VEV DV QAPRAKLDGARL E gdlslaekdv 3466
Cdd:COG2911 460 NLRVLNPPDYTATV - S GDLTLT G T pdgptl SGNVT VP R A RI T L P ELPP S AV S LSD DV VVVNRPPEPVPE E ---------- 528
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3467 takdskfkmpkfkmpsfgv S A P G RSIEAS L D V SAPK vea DV SLSSM ------ Q GDL KA T DLSIQP P SADL E VQA V QVDVE 3540
Cdd:COG2911 529 ------------------- E A A G LPLDLD L N V NLGD --- DV RVRGF gldarl G GDL RL T GTPGGA P RLTG E INL V RGRYN 586
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 156766050 3541 LL egpvpe G AG L K ghlpkvemps LKTPKVDLK GP QI D vkg P K LD L kgp K A EVR V P DV EVSL p S V EVDVQA PK AK L 3615
Cdd:COG2911 587 AY ------ G QR L T ---------- IERGSITFN GP PL D --- P Y LD I --- E A VRT V D DV TAGV - R V TGTASN PK IT L 638
PDZ1_FL-whirlin
cd06740 PDZ domain 1 of the full-length isoform of whirlin and related domains; PDZ (PSD-95 ...
113-181
2.89e-05
PDZ domain 1 of the full-length isoform of whirlin and related domains; PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain 1 of the full-length isoform of whirlin and related domains. Whirlin is an essential protein for developmental pathways in photoreceptor cells of the retina and hair cells of the inner ear. The full-length whirlin isoform has two harmonin N-like domains, three PDZ domains, a proline-rich region, and a PDZ-binding motif. Whirlin isoforms may form different complexes at the periciliary membrane complex (PMC) in photoreceptors, and the stereociliary tip and base in inner ear hair cells. It interacts with ADGRV1 and usherin at the PMC; with SANS and RpgrORF15 at the connecting cilium in photoreceptors; with EPS8, MYO15A, p55, and CASK proteins at the stereociliary tip of inner ear hair cells; and with ADGRV1, usherin, and PDZD7 at the stereociliary base in inner ear hair cells. Mutations in the gene encoding whirlin (WHRN; also known as USH2D and DFNB31), have been found to cause either USH2 subtype (USH2D) or autosomal recessive non-syndromic deafness type 31 (DFNB31). Whirlin is the key protein in the USH2 complex (whirlin, usherin and GPR98) which recruits other USH2 causative proteins at the periciliary membrane in photoreceptors and the ankle link of the stereocilia in hair cells. Whirlin's interaction with espin, another stereociliary protein, may be important for the architecture of the USH2 complex. PDZ domains usually bind in a sequence-specific manner to short peptide sequences located at the C-terminal end of their partner proteins (known as PDZ binding motifs). The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping mediated by beta-strands. This whirlin family PDZ1 domain is a canonical PDZ domain containing six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2), arranged in the order: beta-strands A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F.
Pssm-ID: 467222 [Multi-domain]
Cd Length: 82
Bit Score: 45.43
E-value: 2.89e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 156766050 113 VTLK TEVEAGAS G Y S VT GG GDQ -- GI F V KQ V LKD S S A A K L f N LR E GDQ L L STT - V F FE NIKYED A L KIL QY S 181
Cdd:cd06740 4 VTLK RSKSHEGL G F S IR GG AEH gv GI Y V SL V EPG S L A E K E - G LR V GDQ I L RVN d V S FE KVTHAE A V KIL RV S 74
TamB
COG2911 Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, ...
1515-2101
2.98e-05
Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 442155 [Multi-domain]
Cd Length: 766
Bit Score: 50.81
E-value: 2.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1515 S VD VS A PKVEA D V S LPSM - Q G D L KATD L SIQPPSADLEVQAGQV D VKL PEG PV S eg AG L KGHLPKVQMPSFKMPKVD L KG 1593
Cdd:COG2911 13 G VD LE A DRLRL D W S PLAL l R G R L CIDE L ALSASLDGDRLRLDNL D LDA PEG AL S -- GL L DLVQATLDAEGLDLASSA L DD 90
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1594 PQIDVK G PK L D L K G P -------- KVEVT APD VK m S L SSMEVDV q A PRAKL DG --- AQ L EG D LS LA DKAVTA k D S K FKMPK 1662
Cdd:COG2911 91 LDLRSG G NR L T L S G N lsaasldg DLDLD APD LA - D L AALLPGL - A GSLSG DG lds LS L DA D GT LA QHRLDL - D A K GEPAS 167
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1663 FKMP --- SFGVSAP G KSIEAS - VDVSEPKVE A DVS L PSMQ G DLKTTD L SIQ ----------- SPSA DL EVQAGQVNVK L P 1727
Cdd:COG2911 168 LSLA lsg GLDRDDG G TLSRLD f LNTGRWGLA A PAT L SYDD G RVTLGP L CLA gggslclsgtl GGTL DL QLRLKNLPLA L L 247
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1728 EGP LP EGA G FK G hlpkvqmpslkmpkv A L K G pqmdvkgp KL DL K G PK A evm A P DVEV SL --- PSVEVDVEAP G AK L DSVR 1804
Cdd:COG2911 248 NPF LP DDL G LS G --------------- T L N G -------- DA DL S G GL A --- N P QGDA SL sls GDLTLNDGLG G LP L GLGD 301
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1805 L EGDLS LA DKDV T A kdskfkmpkfkmpsfgvsapgksi EASV D vsapkv EAEVSLP S MQ G DLKTT D LCI P LPSA D LVVQA 1884
Cdd:COG2911 302 L TLNAR LA NGRL T L ------------------------ DLTL D ------ GGGLGTL S LS G SVPLA D GLP P SAPL D GNLRL 351
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1885 GQV D MK L PEGQV P E - GAG L K G H L p KV D mpsfkmpk VD L K G P -------- Q TDVKGAK L D L KGPKAEV T APDVEVSLPSME 1955
Cdd:COG2911 352 DNL D LA L LNPLL P G v LER L S G Q L - NG D -------- LR L S G T laapqlng Q LTLDDGR L K L PALGVRL T DINLRLRFDGDR 422
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1956 VDVQAQK A KLD G -- AR L E G DLS L ADKDMT A k D SKF K MPKFKM psfg VSA P GRSIEA S V D V pap KVEADVSL P SMQ G DLKT 2033
Cdd:COG2911 423 LTLDGLT A DSG G gt LT L S G TVD L DGLSWP A - D LTL K GDNLRV ---- LNP P DYTATV S G D L --- TLTGTPDG P TLS G NVTV 494
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 156766050 2034 TDLS I QP P SADLKVQTGQV DV KLPEGHVPE gaglkgh L P KV E MPS L KM p KV DL K --- G PQ V DIK G PK LD LK 2101
Cdd:COG2911 495 PRAR I TL P ELPPSAVSLSD DV VVVNRPPEP ------- V P EE E AAG L PL - DL DL N vnl G DD V RVR G FG LD AR 557
AsmA
COG2982 Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall ...
2254-2637
3.80e-05
Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442221 [Multi-domain]
Cd Length: 491
Bit Score: 50.04
E-value: 3.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2254 P EI DIK GP KLD L KDPKVEVTAP D VEVSLPSVEV D VK A PGAK LD GA RLE gdms LA D KDVTAK D SKFKM pkfkml SFGVSA L 2333
Cdd:COG2982 107 D EI TLD GP VIN L ERDADGRANW D FLLAAAAAAA D AE A SAWS LD IG RLE ---- IT D GRLVYD D AASGA ------ DLTLDD L 176
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2334 GKSIEASADVSALKVEADVS L psm Q G DLK T T D LSVQPP sad L EVQAGQVDVK L PE G PVP eg AG L K G HL pklqmpsf KMPK 2413
Cdd:COG2982 177 NLTLSGPSLDGPFRLSGSGR L --- N G QPL T L D GKIGGL --- L ALGPYPLKLD L RS G DLR -- LS L D G TV -------- DLAG 240
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2414 V D L kgp Q IDVK GP K L DLKGPKTD V MA P dv E VSQP S VEVDVE A P G --------- AK L DGAW L E GDLSV ADK D VTTKDSRFK 2484
Cdd:COG2982 241 L D G --- Q LALS GP S L RDLLALLG V TL P -- E PGPF S LSGRLT A D G drlrledlk GT L GDSD L T GDLSV TGG D RPALTGDLA 315
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2485 IPKFKMPSFGVS AP GKSIEASVDVSAP ------------ KVE AD GS LS S mq GD LK ATD L SIQPPS A D L EVQA G QV D VKLP 2552
Cdd:COG2982 316 SDRLDLDDLLPA AP AAAAAGAPAAARG lpdapldlsalr ALD AD VR LS A -- DS LK LGG L PLGDLA A H L TLDD G RL D LDPL 393
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2553 EGPVPE G A g L K G H L pkvqmpsfkmp EM D LK G PQLD V KG p KL D L K G PKAEVTA PD VEMS -- LS --- SMEV D VQAPRAKLDG 2627
Cdd:COG2982 394 SAGLYG G T - L S G S L ----------- TL D AR G DPPR V AL - KL S L S G VDLGPLL PD LAGF dr LS gtl NGDL D LSGTGNSVAA 460
410
....*....|..
gi 156766050 2628 -- A R L E G DL SL A 2637
Cdd:COG2982 461 ll A S L N G SA SL S 472
TamB
COG2911 Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, ...
2263-2878
7.95e-05
Autotransporter translocation and assembly protein TamB [Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 442155 [Multi-domain]
Cd Length: 766
Bit Score: 49.27
E-value: 7.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2263 L D L K D PK V EVT A PDVEVSL psvevdvk A P G A ---- K L DGAR L EGDM SL ADKDVTAKDSKFKM P KF kmlsf GV S A L GKSIE 2338
Cdd:COG2911 7 L T L R D DG V DLE A DRLRLDW -------- S P L A llrg R L CIDE L ALSA SL DGDRLRLDNLDLDA P EG ----- AL S G L LDLVQ 73
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2339 A SA D VSA L KVEADV slpsmqgdlk TT DL SVQPPSAD L EVQ a G QVDVKLPE G ---- PV P EG A G L KGH LP K L Q mpsfkm PKV 2414
Cdd:COG2911 74 A TL D AEG L DLASSA ---------- LD DL DLRSGGNR L TLS - G NLSAASLD G dldl DA P DL A D L AAL LP G L A ------ GSL 136
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2415 DLK G pqid VKGPK LD LK G pktdvmapdv EVS Q PSVEV D VEAPG A K L DG A w L E G D L SVA D KDVT tkdsr FKIPKFKMPSF G 2494
Cdd:COG2911 137 SGD G ---- LDSLS LD AD G ---------- TLA Q HRLDL D AKGEP A S L SL A - L S G G L DRD D GGTL ----- SRLDFLNTGRW G 196
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2495 VS AP gksie A SVDVSAPK V EADGSLSSMQ G D L KAT dl SIQPPSA DL EVQAGQVDVK L PEGPV P EGA GL K G hlpkvqmpsf 2574
Cdd:COG2911 197 LA AP ----- A TLSYDDGR V TLGPLCLAGG G S L CLS -- GTLGGTL DL QLRLKNLPLA L LNPFL P DDL GL S G ---------- 259
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2575 kmpem D L K G p QL D VK G PKLDLK G p K A EVTAPD vemsls SMEVDVQAPRAK L DGAR L EGDLS LA DKGV T A k D SKFKMPKFK 2654
Cdd:COG2911 260 ----- T L N G - DA D LS G GLANPQ G - D A SLSLSG ------ DLTLNDGLGGLP L GLGD L TLNAR LA NGRL T L - D LTLDGGGLG 325
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2655 MP S FRV S A P GES --------------------- IEA L VD -- VSE L -- KVEA D MS L ------ P SMQ G D L KTT D ISIQP P SA 2703
Cdd:COG2911 326 TL S LSG S V P LAD glppsapldgnlrldnldlal LNP L LP gv LER L sg QLNG D LR L sgtlaa P QLN G Q L TLD D GRLKL P AL 405
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2704 QLEVQAGQVDVKLPE --------- GHVPE G AG - L K G hlpklqmpsfkmp E VDL K G PQIDV kgp NVD LKG PKAE V T - A PD V 2772
Cdd:COG2911 406 GVRLTDINLRLRFDG drltldglt ADSGG G TL t L S G ------------- T VDL D G LSWPA --- DLT LKG DNLR V L n P PD Y 469
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2773 KMSL S S mev D VQA p RAKL DG AR L E G DL sladkgm T AKDSKFKM P KFKMPSFGV S ----------------- A P G KSIEAS 2835
Cdd:COG2911 470 TATV S G --- D LTL - TGTP DG PT L S G NV ------- T VPRARITL P ELPPSAVSL S ddvvvvnrppepvpeee A A G LPLDLD 538
650 660 670 680
....*....|....*....|....*....|....*....|....*...
gi 156766050 2836 VD V S --- ELK V EAD G SFPSMQ GDL KT T DIRIQP P SA -- QLEVQA G QVD 2878
Cdd:COG2911 539 LN V N lgd DVR V RGF G LDARLG GDL RL T GTPGGA P RL tg EINLVR G RYN 586
AsmA
COG2982 Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall ...
3244-3630
1.36e-04
Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442221 [Multi-domain]
Cd Length: 491
Bit Score: 48.50
E-value: 1.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3244 PQ I DIK GP KLD L kgpkmd VTAP D vev SQPSMEVDVE A PG A KL D GARLEGD L SLAD kd VTAK D SKF kmpkfkmp S Y RAS A P 3323
Cdd:COG2982 107 DE I TLD GP VIN L ------ ERDA D --- GRANWDFLLA A AA A AA D AEASAWS L DIGR -- LEIT D GRL -------- V Y DDA A S 167
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3324 G KSIQAS --- VDV S A P KAEADVS L p S MQ G D L KTTD L SIQLP - SVD L EVQAGQVDVK L PE G HVP eg AG L K G HL pkvempsf 3399
Cdd:COG2982 168 G ADLTLD dln LTL S G P SLDGPFR L - S GS G R L NGQP L TLDGK i GGL L ALGPYPLKLD L RS G DLR -- LS L D G TV -------- 236
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3400 KMPKV D L ksp Q VDIK GP K L DLKVPKAE VT V P ------- DVEVSLPSVEVDVQAPRAK L DGAR L E GDLS LAEK D VT A KDSK 3472
Cdd:COG2982 237 DLAGL D G --- Q LALS GP S L RDLLALLG VT L P epgpfsl SGRLTADGDRLRLEDLKGT L GDSD L T GDLS VTGG D RP A LTGD 313
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3473 FKMPKFKMPSFGVS AP GRSIEAS ----------- LD V SA - PKVE ADV S LS S mq GD LK ATD L SIQPPS A D L EVQAVQV D VE 3540
Cdd:COG2982 314 LASDRLDLDDLLPA AP AAAAAGA paaarglpdap LD L SA l RALD ADV R LS A -- DS LK LGG L PLGDLA A H L TLDDGRL D LD 391
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3541 L L EGPVPE G A g L K G H L pkvempslktp KV D LK G PQID V KG p KL D L K G PKAEVRV PD VEVSLP ----- SVEV D VQAPKAKL 3615
Cdd:COG2982 392 P L SAGLYG G T - L S G S L ----------- TL D AR G DPPR V AL - KL S L S G VDLGPLL PD LAGFDR lsgtl NGDL D LSGTGNSV 458
410
....*....|....*..
gi 156766050 3616 D A -- GR L E G DL SL ADK D 3630
Cdd:COG2982 459 A A ll AS L N G SA SL SLG D 475
AsmA
COG2982 Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall ...
4176-4622
3.86e-04
Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442221 [Multi-domain]
Cd Length: 491
Bit Score: 46.96
E-value: 3.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 4176 LKTT D LSIQS P SADLE --- VQ A GQVDVK L PEG PL pkgag L K G H L pkvqmpcl KMPKVA L K GP QVDV ------ KGPKLD L K 4246
Cdd:COG2982 66 VTLG D VTLSN P DGFGG ppl AS A ERLELD L ALL PL ----- L S G E L -------- EVDEIT L D GP VINL erdadg RANWDF L L 132
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 4247 GPK A DVMTP vvevslpsmev DVE A PGAKLDSVRLE - G D L SLA D K ---- D M T AK D SKFKM pkf KM PS FGVSAP gks IEA S L 4321
Cdd:COG2982 133 AAA A AAADA ----------- EAS A WSLDIGRLEIT d G R L VYD D A asga D L T LD D LNLTL --- SG PS LDGPFR --- LSG S G 195
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 4322 DVSALKVEA D VSLPSM qgdlktth L SIQ P PSAD L EVQA G QEDVK L p E G P V h EG AGL K G H L pklqmp SFKV P KVDLKGPQI 4401
Cdd:COG2982 196 RLNGQPLTL D GKIGGL -------- L ALG P YPLK L DLRS G DLRLS L - D G T V - DL AGL D G Q L ------ ALSG P SLRDLLALL 259
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 4402 D V NV P --- KLD L K G p KVEVTSPN L DVS lpsmev D IQA pga K L DSTR L E GDLS LADK D VT A KDSKFKMPKFKMPSFGMLS P 4478
Cdd:COG2982 260 G V TL P epg PFS L S G - RLTADGDR L RLE ------ D LKG --- T L GDSD L T GDLS VTGG D RP A LTGDLASDRLDLDDLLPAA P 329
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 4479 GKSIEVSVDVSAP ------------ KME AD MSIPS mq GD LK TTD L RIQAPS A D L EVQA G QV DL ----- K L PE G H mpevag 4541
Cdd:COG2982 330 AAAAAGAPAAARG lpdapldlsalr ALD AD VRLSA -- DS LK LGG L PLGDLA A H L TLDD G RL DL dplsa G L YG G T ------ 401
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 4542 L K G H L pkvempsfkmp KV D LK G PQVD V KG p KL D L K G PKAEVMA PD VEVSLP ----- SVET D VQAP G SMLDG -- A R L E G DL 4614
Cdd:COG2982 402 L S G S L ----------- TL D AR G DPPR V AL - KL S L S G VDLGPLL PD LAGFDR lsgtl NGDL D LSGT G NSVAA ll A S L N G SA 469
....*...
gi 156766050 4615 SL AHE D V A 4622
Cdd:COG2982 470 SL SLG D G A 477
AsmA
COG2982 Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall ...
3904-4290
3.93e-04
Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442221 [Multi-domain]
Cd Length: 491
Bit Score: 46.96
E-value: 3.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3904 P EI DIK GP KLD L KDPKVEVTAP D VEVSLPSVEV D V EA PGAK LD GA RLE --- G D L SLA D KDMT A K dskfkmpk FKMPSFGV 3980
Cdd:COG2982 107 D EI TLD GP VIN L ERDADGRANW D FLLAAAAAAA D A EA SAWS LD IG RLE itd G R L VYD D AASG A D -------- LTLDDLNL 178
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3981 SAP G K S MEASVDVTA pkveadvslpsm Q G D L KATD L SVQPPSA - D L EVQAGQVDVK L PE G PVP eg A SL K G HLPKVQMPS f 4059
Cdd:COG2982 179 TLS G P S LDGPFRLSG ------------ S G R L NGQP L TLDGKIG g L L ALGPYPLKLD L RS G DLR -- L SL D G TVDLAGLDG - 243
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 4060 kmp KVD L K GP QIDVKGPK L DLKG P KAEVTAPDVKMSLSSMEVDVQAPRAK L DGVQ L E GDLS LADK D VT A KDSKFKMPKFK 4139
Cdd:COG2982 244 --- QLA L S GP SLRDLLAL L GVTL P EPGPFSLSGRLTADGDRLRLEDLKGT L GDSD L T GDLS VTGG D RP A LTGDLASDRLD 320
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 4140 MPSFGVS AP GKSMEAS ----------- V D V S E L K A - K ADV S L PS mq GD LK TTD L SIQSPS A D L EVQA G QV D VKLPEGP L P 4207
Cdd:COG2982 321 LDDLLPA AP AAAAAGA paaarglpdap L D L S A L R A l D ADV R L SA -- DS LK LGG L PLGDLA A H L TLDD G RL D LDPLSAG L Y 398
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 4208 K G A g L K G H L pkvqmpclkmp KVALK G PQVD V KG p KL D L K G PKADVMT P VVEVSLP ----- SMEV D VEAP G AKLDSVR -- L 4280
Cdd:COG2982 399 G G T - L S G S L ----------- TLDAR G DPPR V AL - KL S L S G VDLGPLL P DLAGFDR lsgtl NGDL D LSGT G NSVAALL as L 465
410
....*....|
gi 156766050 4281 E G DL SL ADK D 4290
Cdd:COG2982 466 N G SA SL SLG D 475
AsmA
COG2982 Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall ...
1518-1980
4.78e-04
Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442221 [Multi-domain]
Cd Length: 491
Bit Score: 46.57
E-value: 4.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1518 V SA PKV E A D VS L PS - MQ G D L KATDLSIQP P SAD LE VQ A - G QVDVKLPEGPVSEG A G lkghl PKVQMP S FKMPKVDLKGPQ 1595
Cdd:COG2982 85 A SA ERL E L D LA L LP l LS G E L EVDEITLDG P VIN LE RD A d G RANWDFLLAAAAAA A D ----- AEASAW S LDIGRLEITDGR 159
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1596 IDVKGPKLDLK gpkve V T AP D VKMS LS SMEV D VQAP --- RAK L D G AQ L EG D LSLADKA vtakdskfkmpkf KMPSFGVSA 1672
Cdd:COG2982 160 LVYDDAASGAD ----- L T LD D LNLT LS GPSL D GPFR lsg SGR L N G QP L TL D GKIGGLL ------------- ALGPYPLKL 221
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1673 PGK S IEASVDVS epkve AD V S L PSMQ G D L KTT dlsiqsp SAD L EVQAGQVN V K LPE GP lpegagfkghlpkvqmpslkmp 1752
Cdd:COG2982 222 DLR S GDLRLSLD ----- GT V D L AGLD G Q L ALS ------- GPS L RDLLALLG V T LPE PG ---------------------- 267
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1753 KVA L K G pqmdvkgpkl D L KGPKAEVMAP D VE vslpsvevdveapg AK L DSVR L E GDLS LADK D VT A KDSKFKMPKFKMPS 1832
Cdd:COG2982 268 PFS L S G ---------- R L TADGDRLRLE D LK -------------- GT L GDSD L T GDLS VTGG D RP A LTGDLASDRLDLDD 323
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1833 FGVS AP GKSIEASVDVSAPKVE A EVS L PSMQ ---------- GD LK TTD L CIPLPS A D L VVQA G QV D MKLPEGQVPE G A g L 1902
Cdd:COG2982 324 LLPA AP AAAAAGAPAAARGLPD A PLD L SALR aldadvrlsa DS LK LGG L PLGDLA A H L TLDD G RL D LDPLSAGLYG G T - L 402
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1903 K G H L pkvdmpsfkmp KV D LK G PQTD V K g A KL D L K G PKAEVTA PD VEVSLP ----- SMEV D VQAQKAKLDG -- A R L E G DL S 1975
Cdd:COG2982 403 S G S L ----------- TL D AR G DPPR V A - L KL S L S G VDLGPLL PD LAGFDR lsgtl NGDL D LSGTGNSVAA ll A S L N G SA S 470
....*
gi 156766050 1976 L ADK D 1980
Cdd:COG2982 471 L SLG D 475
PDZ1_PTPN13_FRMPD2-like
cd06694 PDZ domain 1 of protein tyrosine phosphatase non-receptor type 13 (PTPN13),FERM and PDZ ...
109-193
7.26e-04
PDZ domain 1 of protein tyrosine phosphatase non-receptor type 13 (PTPN13),FERM and PDZ domain-containing protein 2 (FRMPD2), and related domains; PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain 1 of PTPN13 [also known as Fas-associated protein-tyrosine phosphatase 1 (FAP-1), protein-tyrosine phosphatase 1E (PTP-E1), and protein-tyrosine phosphatase (PTPL1)], FRMPD2 (also known as PDZ domain-containing protein 4; PDZ domain-containing protein 5C), and related domains. PTPN13 regulates negative apoptotic signaling and mediates phosphoinositide 3-kinase (PI3K) signaling. PTPN13 has five PDZ domains. Proteins known to interact with PTPN13 PDZ domains include: PLEKHA1 and PLEKHA2 via PTPN13-PDZ domain 1, Fas receptor and thyroid receptor-interacting protein 6 via PTPN13-PDZ domain 2, nerve growth factor receptor and protein kinase N2 via PTPN13-PDZ domain 3, PDZ and LIM domain 4 (PDLIM4) via PTPN13-PDZ domains 2 and 4, and brain calpain-2 via PTPN13-PDZ domains 3, 4 and 5. Calpain-2-mediated PTPN13 fragments may be involved in abnormal tau aggregation and increased risk for Alzheimer's disease. FRMPD2 is localized in the basolateral membranes of polarized epithelial cells and is associated with tight junction formation and immune response; it contains 3 PDZ domains. PDZ domains usually bind in a sequence-specific manner to short peptide sequences located at the C-terminal end of their partner proteins (known as PDZ binding motifs). The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping mediated by beta-strands. This PTPN13 family PDZ1 domain is a canonical PDZ domain containing six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2), arranged in the order: beta-strands A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F.
Pssm-ID: 467180 [Multi-domain]
Cd Length: 92
Bit Score: 42.00
E-value: 7.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 109 E ATE VTLK TEVEA G A s G YSVT GG G ----- D Q GIFVK QVLKDSS A A K LFNLRE GD QLLSTT - VFF E NIKYED A LK I L Q YS e 182
Cdd:cd06694 1 E IVI VTLK KDPQK G L - G FTIV GG E nsgsl D L GIFVK SIIPGGP A D K DGRIKP GD RIIAIN g QSL E GKTHHA A VE I I Q NA - 78
90
....*....|.
gi 156766050 183 P Y KV QFK I RRQ 193
Cdd:cd06694 79 P D KV ELI I SQP 89
AsmA
COG2982 Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall ...
3454-3960
7.52e-04
Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442221 [Multi-domain]
Cd Length: 491
Bit Score: 45.80
E-value: 7.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3454 RLE GDLSL aekdvtakd S K F KM P KFKMPSFGV S A P GRSIEAS L d V SA PKV E A D VS L SS - MQ G D L KATDLSIQP P SAD LE V 3532
Cdd:COG2982 51 TID GDLSL --------- S L F PW P GVTLGDVTL S N P DGFGGPP L - A SA ERL E L D LA L LP l LS G E L EVDEITLDG P VIN LE R 120
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3533 Q A vqvdvell E G p VPEGAG L KGHLPKVEMPSLKTPKV D LKG pq IDVKGPK L DLKGPKAEV rvp D VEVSLPSVEVDVQAPK 3612
Cdd:COG2982 121 D A -------- D G - RANWDF L LAAAAAAADAEASAWSL D IGR -- LEITDGR L VYDDAASGA --- D LTLDDLNLTLSGPSLD 186
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3613 AKL dag RL E G DLS L ADKDV T A k D S K FKMP k FKMPSFRVSAPGK S MEASVDVSA pkvea D V S L PSMQ G D L KTT dlsiqpp S 3692
Cdd:COG2982 187 GPF --- RL S G SGR L NGQPL T L - D G K IGGL - LALGPYPLKLDLR S GDLRLSLDG ----- T V D L AGLD G Q L ALS ------- G 249
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3693 AD L KVQAGQMD V K LPE GQ vpegaglkehlpkvempslkmp KVD L K G pqvdikgpkl D L KVSKAEVTAP D V evslpsvevd 3772
Cdd:COG2982 250 PS L RDLLALLG V T LPE PG ---------------------- PFS L S G ---------- R L TADGDRLRLE D L ---------- 287
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3773 vqap RAK L DSAQ L E GDLS LADK D VT A KDSKFKMPKFKMPSFGVS AP GKSIEASVHVSAPKVE A DVS L PSMQ --------- 3843
Cdd:COG2982 288 ---- KGT L GDSD L T GDLS VTGG D RP A LTGDLASDRLDLDDLLPA AP AAAAAGAPAAARGLPD A PLD L SALR aldadvrls 363
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3844 - GD LK TTD L SIQPHS A D LT VQARQV D MKL L EGHVPEEA g L K G H L pkvqmpsfkmp KV D LK G PEIDIKG p KL D L KDPKVEV 3922
Cdd:COG2982 364 a DS LK LGG L PLGDLA A H LT LDDGRL D LDP L SAGLYGGT - L S G S L ----------- TL D AR G DPPRVAL - KL S L SGVDLGP 430
490 500 510 520
....*....|....*....|....*....|....*....|....*
gi 156766050 3923 TA PD VEVSLP ----- SVEV D VEAP G AKLDG -- A R L E G DL SL ADK D 3960
Cdd:COG2982 431 LL PD LAGFDR lsgtl NGDL D LSGT G NSVAA ll A S L N G SA SL SLG D 475
PTZ00121
PTZ00121 MAEBL; Provisional
427-677
9.79e-04
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain]
Cd Length: 2084
Bit Score: 45.90
E-value: 9.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 427 Q A Q E TAV A QR K PR A QPT pgm SREG E GEGLQSLEIGI A RLSLRDTT E GGTQIGPP E IRVRVHDL K TP --- K FAFSTE K EP E 503
Cdd:PTZ00121 1553 K A E E LKK A EE K KK A EEA --- KKAE E DKNMALRKAEE A KKAEEARI E EVMKLYEE E KKMKAEEA K KA eea K IKAEEL K KA E 1629
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 504 R E RRLSTPQRG K RQDASS KA GTGL K G EE VEGA gwmpg REPTTHAE A QG D EGDG EE glqr TRIT EE QD K GREDTEGQIRMP 583
Cdd:PTZ00121 1630 E E KKKVEQLKK K EAEEKK KA EELK K A EE ENKI ----- KAAEEAKK A EE D KKKA EE ---- AKKA EE DE K KAAEALKKEAEE 1700
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 584 KF K IPS L GWSPSKHT K TGR E KATEDT E QGREG E ATATADRREQRRT EE GL KD K E DSDSMTNTT K IQLIHD E KRL K KEQIL 663
Cdd:PTZ00121 1701 AK K AEE L KKKEAEEK K KAE E LKKAEE E NKIKA E EAKKEAEEDKKKA EE AK KD E E EKKKIAHLK K EEEKKA E EIR K EKEAV 1780
250
....*....|....
gi 156766050 664 T E K E VATK D S K FK M 677
Cdd:PTZ00121 1781 I E E E LDEE D E K RR M 1794
PDZ
smart00228 Domain present in PSD-95, Dlg, and ZO-1/2; Also called DHR (Dlg homologous region) or GLGF ...
125-193
1.22e-03
Domain present in PSD-95, Dlg, and ZO-1/2; Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides; others appear to bind internal (non-C-terminal) polypeptides. Different PDZs possess different binding specificities.
Pssm-ID: 214570 [Multi-domain]
Cd Length: 85
Bit Score: 40.83
E-value: 1.22e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 156766050 125 G Y S VT GG G D -- Q G IF V KQ V LKD S S AAK L f N LR E GD QL L S - TTVFF E NIKYED A LKI L QYSEP y KV QFKIR R Q 193
Cdd:smart00228 15 G F S LV GG K D eg G G VV V SS V VPG S P AAK A - G LR V GD VI L E v NGTSV E GLTHLE A VDL L KKAGG - KV TLTVL R G 84
AsmA
COG2982 Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall ...
1759-2145
1.39e-03
Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442221 [Multi-domain]
Cd Length: 491
Bit Score: 45.03
E-value: 1.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1759 PQMDVK GP KLD L KGPKAEVMAP D VEVSLPSVEV D V EA PGAK -- LDSVRLE - G D L SLA D K ---- D V T AK D SKFKM pkfkmp 1831
Cdd:COG2982 107 DEITLD GP VIN L ERDADGRANW D FLLAAAAAAA D A EA SAWS ld IGRLEIT d G R L VYD D A asga D L T LD D LNLTL ------ 180
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1832 sf GVSAPGKSIEA S VDVSAPKVEAEVSLP - SMQGD L KTTD L CIP L P S A DL VVQA - G Q VD M klpegqvpeg AGL K G H L p KV 1909
Cdd:COG2982 181 -- SGPSLDGPFRL S GSGRLNGQPLTLDGK i GGLLA L GPYP L KLD L R S G DL RLSL d G T VD L ---------- AGL D G Q L - AL 247
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1910 DM PS FK -- MPKVDLKG P QTDVKGAKLD L KGPKAEVTAP D V evslpsmevdvqaq K AK L DGAR L E GDLS LADK D MT A KDSK 1987
Cdd:COG2982 248 SG PS LR dl LALLGVTL P EPGPFSLSGR L TADGDRLRLE D L -------------- K GT L GDSD L T GDLS VTGG D RP A LTGD 313
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 1988 FKMPKFKMPSFGVS AP GRSIEASVDVPAPKVE A DVS L PSMQ ---------- GD LK TTD L SIQPPS A D L KVQT G QV D VKLP 2057
Cdd:COG2982 314 LASDRLDLDDLLPA AP AAAAAGAPAAARGLPD A PLD L SALR aldadvrlsa DS LK LGG L PLGDLA A H L TLDD G RL D LDPL 393
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 2058 EGHVPE G A g L K G H L pkvempslkmp KV D LK G PQVDIKG p KL D L KDPKVEMRV PD VEVSLP ----- SMEV D VQAPRAKLDS 2132
Cdd:COG2982 394 SAGLYG G T - L S G S L ----------- TL D AR G DPPRVAL - KL S L SGVDLGPLL PD LAGFDR lsgtl NGDL D LSGTGNSVAA 460
410
....*....|....*
gi 156766050 2133 -- A H L Q G DLT L ANK D 2145
Cdd:COG2982 461 ll A S L N G SAS L SLG D 475
PDZ13_MUPP1-like
cd06676 PDZ domain 13 of multi-PDZ-domain protein 1 (MUPP1) and related domains; PDZ (PSD-95 ...
118-179
1.60e-03
PDZ domain 13 of multi-PDZ-domain protein 1 (MUPP1) and related domains; PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain 13 of MUPP1. MUPP1 and PATJ serve as scaffolding proteins linking different proteins and protein complexes involved in the organization of tight junctions and epithelial polarity. MUPP1 contains an L27 (Lin-2 and Lin-7 binding) domain and 13 PDZ domains. PATJ (also known as INAD-like) contains an L27 domain and ten PDZ domains. PATJ lacks 3 PDZ domains seen in MUPP1: PDZ6, PDZ9, and PDZ13. This MuPP1-like PDZ13 domain is therefore absent from PATJ. MUPP1 and PATJ share several binding partners, including junctional adhesion molecules (JAM), zonula occludens (ZO)-3, Pals1 (protein associated with Lin-7), Par (partitioning defective)-6 proteins, and nectins (adherence junction adhesion molecules). PDZ domains usually bind in a sequence-specific manner to short peptide sequences located at the C-terminal end of their partner proteins (known as PDZ binding motifs). The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping mediated by beta-strands. This MUPP1-like family PDZ13 domain is a canonical PDZ domain containing six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2), arranged in the order: beta-strands A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F.
Pssm-ID: 467164 [Multi-domain]
Cd Length: 83
Bit Score: 40.40
E-value: 1.60e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 118 EV E A G AS G Y -- S VT GG ----- GD QG I F VK Q V LKDSS AA KLFN L RE GDQ L L STT - VFF E NIKY E D A LK IL Q 179
Cdd:cd06676 3 TL E R G SD G L gf S IV GG fgsph GD LP I Y VK T V FEKGA AA EDGR L KR GDQ I L AVN g ESL E GVTH E E A VN IL K 72
PDZ2_ZO1-like_ds
cd06728 PDZ domain 2 of Zonula Occludens-1 (ZO-1), ZO-2 and ZO-3, and related domains; form ...
136-193
1.61e-03
PDZ domain 2 of Zonula Occludens-1 (ZO-1), ZO-2 and ZO-3, and related domains; form domain-swapping dimers; PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain 2 of ZO-1, -2, -3 and related domains. Zonula occludens proteins (ZO-1, ZO-2, ZO-3) are multi-PDZ domain proteins involved in the maintenance and biogenesis of multi-protein networks at the cytoplasmic surface of intercellular contacts in epithelial and endothelial cells. They have three N-terminal PDZ domains, PDZ1-3, followed by a Src homology-3 (SH3) domain and a guanylate kinase (GuK)-like domain. Among protein-protein interactions for all ZO proteins is the binding of the first PDZ domain (PDZ1) to the C-termini of claudins , and the homo- and hetero-dimerization of ZO-proteins via their second PDZ domain (PDZ2), which takes place by symmetrical domain swapping of the first two beta-strands of PDZ2. At the cell level, ZO-1 and ZO-2 are involved in polarity maintenance, gene transcription, cell proliferation, and tumor cell metastasis. PDZ domains usually bind in a sequence-specific manner to short peptide sequences located at the C-terminal end of their partner proteins (known as PDZ binding motifs). The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping mediated by beta-strands. This ZO family PDZ2 domain is a canonical PDZ domain containing six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2), arranged in the order: beta-strands A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F.
Pssm-ID: 467210 [Multi-domain]
Cd Length: 79
Bit Score: 40.28
E-value: 1.61e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 156766050 136 IFVK QVLK DS S AAK LF NL R EGD QL L --- S T T V ff EN IKYED A L K ILQY S EP y K V Q FKIR R Q 193
Cdd:cd06728 22 IFVK EITP DS L AAK DG NL Q EGD II L kin G T P V -- EN LSLSE A K K LIEK S KD - K L Q LVVL R D 79
PDZ3_PDZD2-PDZ1_hPro-IL-16-like
cd06759 PDZ domain 3 of PDZ domain containing 2 (PDZD2), PDZ domain 1 of human pro-interleukin-16 ...
111-161
2.19e-03
PDZ domain 3 of PDZ domain containing 2 (PDZD2), PDZ domain 1 of human pro-interleukin-16 (isoform 1, 1332 AA), and related domains; PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain 3 of PDZD2, also known as KIAA0300, PIN-1, activated in prostate cancer (AIPC) and PDZ domain-containing protein 3 (PDZK3). PDZD2 has seven PDZ domains. PDZD2 is expressed at exceptionally high levels in the pancreas and certain cancer tissues, such as prostate cancer. It promotes the proliferation of insulinoma cells and is upregulated during prostate tumorigenesis. In osteosarcoma (OS), the microRNA miR-363 acts as a tumor suppressor by inhibiting PDZD2. This family also includes the first PDZ domain (PDZ1) of human pro-interleukin-16 (isoform 1, also known as nPro-Il-16; 1332 amino-acid protein). Precursor IL-16 is cleaved to produce pro-IL-16 and mature IL-16 (derived from the C-terminal 121 AA). Pro-IL-16 functions as a regulator of T cell growth; mature IL-16 is a CD4 ligand that induces chemotaxis and CD25 expression in CD4+ T cells. IL-16 bioactivity has been closely associated with the progression of several different cancers. PDZ domains usually bind in a sequence-specific manner to short peptide sequences located at the C-terminal end of their partner proteins (known as PDZ binding motifs). The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping mediated by beta-strands. This PDZD2-like family PDZ3 domain is a canonical PDZ domain containing six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2), arranged in the order: beta-strands A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F.
Pssm-ID: 467240 [Multi-domain]
Cd Length: 87
Bit Score: 40.34
E-value: 2.19e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 156766050 111 TEVT L KTEVEAGAS G Y S VT GG ----- G DQ GI F VK QVLKDSS AA KLFN L R EGD QL L S 161
Cdd:cd06759 1 STIV L MKGAGGKGL G F S IV GG rdspr G PM GI Y VK TIFPGGA AA EDGR L K EGD EI L E 56
PDZ1_PDZD7-like
cd10833 PDZ domain 1 of the canonical isoform 1 of PDZ domain containing 7 (PDZD7), and related ...
120-181
2.21e-03
PDZ domain 1 of the canonical isoform 1 of PDZ domain containing 7 (PDZD7), and related domains; PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain 1 of the long isoform 1 of PDZD7, and related domains. PDZD7 is critical for the organization of Usher syndrome type 2 (USH2) complex. Usher syndrome is the leading cause of hereditary sensory deaf-blindness in humans; USH2 is the most common sub-type. Formation of the USH2 complex is based upon heterodimerization between PDZD7 and whirlin (another PDZ domain-containing protein) and a subsequent dynamic interplay between USH2 proteins via their multiple PDZ domains. The PDZD7 PDZ2 domain binds GPR98 (also known as VLGR1) and usherin (USH2A). PDZD7 and whirlin form heterodimers through their multiple PDZ domains; whirlin and PDZD7 interact with usherin and GPR98 to form an interdependent ankle link complex. PDZD7 also interacts with myosin VIIa. PDZD7 also forms homodimers through its PDZ2 domain. Various isoforms of PDZD7 produced by alternative splicing have been identified; this subgroup includes the first PDZ domain of the canonical isoform of PDZD7- isoform 1. PDZ domains usually bind in a sequence-specific manner to short peptide sequences located at the C-terminal end of their partner proteins (known as PDZ binding motifs). The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping mediated by beta-strands. This PDZD7-like family PDZ1 domain is a canonical PDZ domain containing six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2), arranged in the order: beta-strands A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F.
Pssm-ID: 467269 [Multi-domain]
Cd Length: 84
Bit Score: 40.11
E-value: 2.21e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 156766050 120 EA G AS G Y SV T GG GDQ G -- IFV KQ V LKD S S A AKL f N L RE GD QLLS - TT V FF ENI KYED A L K I L QY S 181
Cdd:cd10833 10 PD G SL G F SV R GG SEH G lg IFV SK V EEG S A A ERA - G L CV GD KITE v NG V SL ENI TMSS A V K V L TG S 73
PDZ_densin_erbin-like
cd06749 PDZ domain of densin, erbin, and related domains; PDZ (PSD-95 (Postsynaptic density protein 95) ...
125-179
2.54e-03
PDZ domain of densin, erbin, and related domains; PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain of densin, erbin, and related domains. Densin (also known as leucine-rich repeat-containing protein 7, LRRC7, densin-180, protein LAP1) and erbin (also known as densin-180-like protein, Erbb2-interacting protein, protein LAP2) belong to the LAP (leucine-rich repeat and PDZ domain) family of scaffolding proteins that play roles in the maintenance of cell shape and apical-basal polarity. Densin and erbin are components of the excitatory postsynaptic compartment and are regulators of dendritic morphology and postsynaptic structure. The densin PDZ domain binds CaV1.3 alpha1 subunit, delta-catenin, and MAGUIN-1. Binding partners of the erbin PDZ domain include ErbB receptor tyrosine kinase ErbB2, HTLV-1 Tax1, Cav1.3 Ca2+channels, and constituents of the cadherin:catenin cell adhesion complex, in particular delta-catenin, p0071 and ARVCF. The erbin PDZ domain binds Smad3, a transductor of the TGFbeta pathway, possibly by a novel interface of binding. Erbin and two other LAP proteins (scribble and lano) redundantly regulate epithelial polarity and apical adhesion complex. PDZ domains usually bind in a sequence-specific manner to short peptide sequences located at the C-terminal end of their partner proteins (known as PDZ binding motifs). The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping mediated by beta-strands. This densin and erbin-like family domain is a canonical PDZ domain containing six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2), arranged as beta-strands A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F.
Pssm-ID: 467231 [Multi-domain]
Cd Length: 87
Bit Score: 40.00
E-value: 2.54e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 156766050 125 G Y S VT GG ---------- G D Q GIFV KQ V LK D SS A A KL fn L RE GD QL L STT - VF F E NI KYED A LKI L Q 179
Cdd:cd06749 12 G F S IS GG igsqgnpfrp D D D GIFV TK V QP D GP A S KL -- L QP GD KI L EVN g YD F V NI EHGQ A VSL L K 75
PDZ2-PTPN13_FRMPD2-like
cd06792 PDZ domain 2 of tyrosine kinase PTPN13, FERM and PDZ domain-containing protein 2 (FRMPD2), and ...
109-179
2.78e-03
PDZ domain 2 of tyrosine kinase PTPN13, FERM and PDZ domain-containing protein 2 (FRMPD2), and similar domains; PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain 2 of human PTPN13, and related domains. PTPN13, also known as Fas-associated protein-tyrosine phosphatase 1 (FAP-1), protein-tyrosine phosphatase 1E (PTP-E1), and protein-tyrosine phosphatase (PTPL1), negatively regulates FAS-mediated apoptosis and NGFR-mediated pro-apoptotic signaling, and may also regulate phosphoinositide 3-kinase (PI3K) signaling. It contains 5 PDZ domains; interaction partners of its second PDZ domain (PDZ2) include the Fas receptor (TNFRSF6) and thyroid receptor-interacting protein 6 (TRIP6). The second PDZ (PDZ2) domain, but not PDZ1 or PDZ3, of FRMPD2 binds to GluN2A and GluN2B, two subunits of N-methyl-d-aspartic acid (NMDA) receptors. Other binding partners of the FRMPDZ2 PDZ2 domain include NOD2, and catenin family members, delta catenin (CTNND2), armadillo repeat gene deleted in velo-cardio-facial syndrome (ARVCF) and p0071 (also known as plakophilin 4; PKP4). PDZ domains usually bind in a sequence-specific manner to short peptide sequences located at the C-terminal end of their partner proteins (known as PDZ binding motifs). The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping mediated by beta-strands. This PTPN13-like family PDZ2 domain is a canonical PDZ domain containing six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2), arranged in the order: beta-strands A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F.
Pssm-ID: 467254 [Multi-domain]
Cd Length: 87
Bit Score: 39.89
E-value: 2.78e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 156766050 109 EAT EV T L KTEV ea G AS G Y SVTGG GDQ ----- GI F VK QVLKDSS A AKLFNLRE GD Q LL STT - V FF E NIKYED A LKI L Q 179
Cdd:cd06792 1 DVF EV E L SKKD -- G SL G I SVTGG INT svrhg GI Y VK SLVPGGA A EQDGRIQK GD R LL EVN g V SL E GVTHKQ A VEC L K 75
AsmA
COG2982 Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall ...
3079-3384
2.83e-03
Uncharacterized conserved protein AsmA involved in outer membrane biogenesis [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442221 [Multi-domain]
Cd Length: 491
Bit Score: 43.87
E-value: 2.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3079 PQ I DVK GP KLD L KGPKTDVTAP D VEVSQPGMEV D V EA PGAK LD GA RLE --- G D L SLA D K ---- D V T AK D SKFKM pkfkmp 3151
Cdd:COG2982 107 DE I TLD GP VIN L ERDADGRANW D FLLAAAAAAA D A EA SAWS LD IG RLE itd G R L VYD D A asga D L T LD D LNLTL ------ 180
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3152 sf GVSAPGKSIEVLVDVSAPKVEAD L SL p SMQ G D L KNTDISI eppsa Q L EVQA G QVDVK L p E G H V l EG AGL K G H L p K L QM 3231
Cdd:COG2982 181 -- SGPSLDGPFRLSGSGRLNGQPLT L DG - KIG G L L ALGPYPL ----- K L DLRS G DLRLS L - D G T V - DL AGL D G Q L - A L SG 249
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3232 PS FK -- MPKVDRKG P Q idik GPKLD L K G p KMDVTAPDVEVSQPS mevdveapg AK L DGAR L E GDLS LADK D VT A KDSKFK 3309
Cdd:COG2982 250 PS LR dl LALLGVTL P E ---- PGPFS L S G - RLTADGDRLRLEDLK --------- GT L GDSD L T GDLS VTGG D RP A LTGDLA 315
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156766050 3310 MPKFKMPSYRAS AP GKSIQASVDVSAPKAE A DVS L PSMQ ---------- GD LK TTD L SIQLPSVD L EVQA G QV D VKLPEG 3379
Cdd:COG2982 316 SDRLDLDDLLPA AP AAAAAGAPAAARGLPD A PLD L SALR aldadvrlsa DS LK LGG L PLGDLAAH L TLDD G RL D LDPLSA 395
....*
gi 156766050 3380 HVPE G 3384
Cdd:COG2982 396 GLYG G 400
PDZ3_ZO1-like_domain
cd06729 PDZ domain 3 of Zonula Occludens-1 (ZO-1), homologs ZO-2 and ZO-3, and related domains; PDZ ...
122-178
2.93e-03
PDZ domain 3 of Zonula Occludens-1 (ZO-1), homologs ZO-2 and ZO-3, and related domains; PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain 3 of ZO-1, -2, -3 and related domains. Zonula occludens proteins (ZO-1, ZO-2, ZO-3) are multi-PDZ domain proteins involved in the maintenance and biogenesis of multi-protein networks at the cytoplasmic surface of intercellular contacts in epithelial and endothelial cells. They have three N-terminal PDZ domains, PDZ1-3, followed by a Src homology-3 (SH3) domain and a guanylate kinase (GuK)-like domain. Among protein-protein interactions for all ZO proteins is the binding of the first PDZ domain (PDZ1) to the C-termini of claudins , and the homo- and hetero-dimerization of ZO-proteins via their second PDZ domain (PDZ2), which takes place by symmetrical domain swapping of the first two beta-strands of PDZ2. At the cell level, ZO-1 and ZO-2 are involved in polarity maintenance, gene transcription, cell proliferation, and tumor cell metastasis. PDZ domains usually bind in a sequence-specific manner to short peptide sequences located at the C-terminal end of their partner proteins (known as PDZ binding motifs). The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping mediated by beta-strands. This ZO family PDZ3 domain is a canonical PDZ domain containing six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2), arranged in the order: beta-strands A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F.
Pssm-ID: 467211 [Multi-domain]
Cd Length: 82
Bit Score: 39.86
E-value: 2.93e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 156766050 122 G AS G YSVT GG G D Q GIFV KQ V LKD S S A A K L f N L R EGDQ L L S - TT V F F E N IKY E D A LKI L 178
Cdd:cd06729 11 G SV G LRLA GG N D V GIFV AG V QEG S P A E K Q - G L Q EGDQ I L K v NG V D F R N LTR E E A VLF L 67
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
