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Conserved domains on  [gi|1566407268|gb|QAZ37977|]
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PQQ-dependent dehydrogenase, methanol/ethanol family [Methylibium sp. Pch-M]

Protein Classification

methanol/ethanol family PQQ-dependent dehydrogenase( domain architecture ID 10178893)

methanol/ethanol family PQQ-dependent dehydrogenase similar to Thauera butanivorans 1-butanol dehydrogenase (quinone) that catalyzes the oxidation of 1-butanol to 1-butanal and may function primarily in energy generation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PQQ_ADH_I cd10277
Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); ...
 60-583 0e+00

Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); This bacterial family of homodimeric ethanol dehydrogenases utilize pyrroloquinoline quinone (PQQ) as a cofactor. It represents proteins whose expression may be induced by ethanol, and which are similar to quinoprotein methanol dehydrogenases, but have higher specificities for ethanol and other primary and secondary alcohols. Dehydrogenases with PQQ cofactors, such as ethanol, methanol, and membrane-bound glucose dehydrogenases, form an 8-bladed beta-propeller.


:

Pssm-ID: 199835 [Multi-domain]  Cd Length: 529  Bit Score: 783.41  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268  60 LLNADKDANNWLHYGKDYQNTRFSALTQITTDNVKKLVPKWNLSFGV-NEAQDSQTTVVNGRIYVTASQNKVFSLDGVTG 138
Cdd:cd10277     1 LLNDAKETGNWLTYGRGYNGQRYSPLKQINTDNVKNLVPAWSFSFGGkQRGQESQPIVNDGVMYVTTSYNRVFAIDAKTG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 139 KMLWKYERSLPGDLGPklCCDAVNRGVAVYKDMVFMATLDTHVVALNNTTGQVVWERKMGDYQTGEIYTSMPLVAKGMVI 218
Cdd:cd10277    81 KELWKYKHRLPEDIRP--CCDVVNRGVALYGDKVYFGTLDAHLVALDAKTGKVVWKKKVADYKAGYSMTLAPLVVKGKVI 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 219 VGNSGGDVGaNVGRITALDPATGNTIWEFKTRPTSADHPQAKTWANDSWKTGGGSAWLTGTYDAKTNTVLWGVGNPAPDF 298
Cdd:cd10277   159 VGVSGGEFG-VRGFIAALDAETGKEVWRTYTVPGPGEPGSTDTWPGDAWKTGGGATWLTGTYDPETNLLYWGVGNPAPWN 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 299 DPsVRKGDNLYTNSTVALDADTGKIKYHFQYTPNDAWDYDGNNEMILVD---DDKGRKVWLHGDRNGHLYSIDRTNGKCN 375
Cdd:cd10277   238 GD-LRPGDNLYTSSVLALDPDTGKIKWHYQYTPNDTWDYDGVNEPVLFDytkNGKPVKALVHADRNGFFYVLDRTNGKLI 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 376 WVVPIARVNWVT-GFGDNCRPIVNPDKVPGYDRIATDIAPILDGGKEWHPAAYSLRTKLVYVPFIDSSMDVQAKKSEWKK 454
Cdd:cd10277   317 WATPFVKKITWAsIDLKTGRPIYDEDKVPPKKGKTVDFCPSFLGGKNWPPMAYSPDTGLFYVPANHWCMDLTGEPVSYKK 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 455 GEWFLSSKVLK---ANPYTGGVKAFNATTGEQVWTRPQSTPATSGLLATAGKLVFSGDAEGYFSALKDDTGEELWRFNVG 531
Cdd:cd10277   397 GAAYLGAGFTIkppFEDHIGELQAIDPTTGKKVWEHKTPLPLWGGVLTTAGGLVFTGTPDGYFRAFDAKTGKELWEFQTG 476

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1566407268 532 SGIHGNPTTFTADGKQYVAIVYGPGGGSLWPLVYDE-LFKRNNRGGGMMVFGL 583
Cdd:cd10277   477 SGIIGPPVTWEVDGKQYVAVLSGWGGAAPLWGGDMAkLLKNVPQGGSLWVFAL 529
 
Name Accession Description Interval E-value
PQQ_ADH_I cd10277
Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); ...
 60-583 0e+00

Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); This bacterial family of homodimeric ethanol dehydrogenases utilize pyrroloquinoline quinone (PQQ) as a cofactor. It represents proteins whose expression may be induced by ethanol, and which are similar to quinoprotein methanol dehydrogenases, but have higher specificities for ethanol and other primary and secondary alcohols. Dehydrogenases with PQQ cofactors, such as ethanol, methanol, and membrane-bound glucose dehydrogenases, form an 8-bladed beta-propeller.


Pssm-ID: 199835 [Multi-domain]  Cd Length: 529  Bit Score: 783.41  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268  60 LLNADKDANNWLHYGKDYQNTRFSALTQITTDNVKKLVPKWNLSFGV-NEAQDSQTTVVNGRIYVTASQNKVFSLDGVTG 138
Cdd:cd10277     1 LLNDAKETGNWLTYGRGYNGQRYSPLKQINTDNVKNLVPAWSFSFGGkQRGQESQPIVNDGVMYVTTSYNRVFAIDAKTG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 139 KMLWKYERSLPGDLGPklCCDAVNRGVAVYKDMVFMATLDTHVVALNNTTGQVVWERKMGDYQTGEIYTSMPLVAKGMVI 218
Cdd:cd10277    81 KELWKYKHRLPEDIRP--CCDVVNRGVALYGDKVYFGTLDAHLVALDAKTGKVVWKKKVADYKAGYSMTLAPLVVKGKVI 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 219 VGNSGGDVGaNVGRITALDPATGNTIWEFKTRPTSADHPQAKTWANDSWKTGGGSAWLTGTYDAKTNTVLWGVGNPAPDF 298
Cdd:cd10277   159 VGVSGGEFG-VRGFIAALDAETGKEVWRTYTVPGPGEPGSTDTWPGDAWKTGGGATWLTGTYDPETNLLYWGVGNPAPWN 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 299 DPsVRKGDNLYTNSTVALDADTGKIKYHFQYTPNDAWDYDGNNEMILVD---DDKGRKVWLHGDRNGHLYSIDRTNGKCN 375
Cdd:cd10277   238 GD-LRPGDNLYTSSVLALDPDTGKIKWHYQYTPNDTWDYDGVNEPVLFDytkNGKPVKALVHADRNGFFYVLDRTNGKLI 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 376 WVVPIARVNWVT-GFGDNCRPIVNPDKVPGYDRIATDIAPILDGGKEWHPAAYSLRTKLVYVPFIDSSMDVQAKKSEWKK 454
Cdd:cd10277   317 WATPFVKKITWAsIDLKTGRPIYDEDKVPPKKGKTVDFCPSFLGGKNWPPMAYSPDTGLFYVPANHWCMDLTGEPVSYKK 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 455 GEWFLSSKVLK---ANPYTGGVKAFNATTGEQVWTRPQSTPATSGLLATAGKLVFSGDAEGYFSALKDDTGEELWRFNVG 531
Cdd:cd10277   397 GAAYLGAGFTIkppFEDHIGELQAIDPTTGKKVWEHKTPLPLWGGVLTTAGGLVFTGTPDGYFRAFDAKTGKELWEFQTG 476

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1566407268 532 SGIHGNPTTFTADGKQYVAIVYGPGGGSLWPLVYDE-LFKRNNRGGGMMVFGL 583
Cdd:cd10277   477 SGIIGPPVTWEVDGKQYVAVLSGWGGAAPLWGGDMAkLLKNVPQGGSLWVFAL 529
PQQ_enz_alc_DH TIGR03075
PQQ-dependent dehydrogenase, methanol/ethanol family; This protein family has a phylogenetic ...
 55-557 0e+00

PQQ-dependent dehydrogenase, methanol/ethanol family; This protein family has a phylogenetic distribution very similar to that coenzyme PQQ biosynthesis enzymes, as shown by partial phylogenetic profiling. Genes in this family often are found adjacent to the PQQ biosynthesis genes themselves. An unusual, strained disulfide bond between adjacent Cys residues contributes to PQQ-binding, as does a Trp residue that is part of a PQQ enzyme repeat (see pfam01011). Characterized members include the dehydrogenase subunit of a membrane-anchored, three subunit alcohol (ethanol) dehydrogenase of Gluconobacter suboxydans, a homodimeric ethanol dehydrogenase in Pseudomonas aeruginosa, and the large subunit of an alpha2/beta2 heterotetrameric methanol dehydrogenase in Methylobacterium extorquens.


Pssm-ID: 274419 [Multi-domain]  Cd Length: 527  Bit Score: 591.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268  55 VSNDMLLNADKDANNWLHYGKDYQNTRFSALTQITTDNVKKLVPKWNLSFGVNEAQDSQTTVVNGRIYVTASQNKVFSLD 134
Cdd:TIGR03075   6 VTNEDLLNDAKDPSDWLTYGGGYAGQRYSPLDQINTDNVKKLQPAWTFSLGKQRGQESQPLVVDGVMYVTTSYSRVYALD 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 135 GVTGKMLWKYERSLPGDLGPKLCCDAVNRGVAVYKDMVFMATLDTHVVALNNTTGQVVWERKMGDYQTGEIYTSMPLVAK 214
Cdd:TIGR03075  86 AKTGKILWKYDPKLPDDIIPVMCCDVVNRGAALYDGKVFFGTLDARLVALDAKTGKVVWSKKNGDYKKGYTITAAPLVVK 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 215 GMVIVGNSGGDVGAnVGRITALDPATGNTIW------------EFKTRPTSADhPQAKTWANDSWKTGGGSAWLTGTYDA 282
Cdd:TIGR03075 166 GKVITGISGGEFGV-RGYVTAYDAKTGKLVWrrytvpgdmgylKKTGKPVGGD-PGAKTWPGDAWKTGGGATWGTGSYDP 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 283 KTNTVLWGVGNPAPdFDPSVRKGDNLYTNSTVALDADTGKIKYHFQYTPNDAWDYDGNNEMILVD---DDKGRKVWLHGD 359
Cdd:TIGR03075 244 ETNLIYFGTGNPAP-WNSHLRPGDNLYTSSIVARDPDTGKIKWHYQTTPHDEWDYDGVNEMILFDlkkDGKPRKLLAHAD 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 360 RNGHLYSIDRTNGKCNWVVP-IARVNWVTGF-GDNCRPIVNPDKVP--GYDRIATDIAPILDGGKEWHPAAYSLRTKLVY 435
Cdd:TIGR03075 323 RNGFFYVLDRTNGKLLSAEPfVDKVNWATGVdLKTGRPIEVPEARStdGKKGKPVEVCPGFLGGKNWQPMAYSPKTGLFY 402

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 436 VPFIDSSMDVQAKKSEWKKGEWFL----SSKVLKaNPYTGGVKAFNATTGEQVWTRPQSTPATSGLLATAGKLVFSGDAE 511
Cdd:TIGR03075 403 VPANHVCMDYWPEKVSYKKGAAYLgagfTIKPPP-DDHIGSLIAWDPITGKIVWEHKEDFPLWGGVLATAGDLVFTGTLE 481

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 1566407268 512 GYFSALKDDTGEELWRFNVGSGIHGNPTTFTADGKQYVAIVYGPGG 557
Cdd:TIGR03075 482 GYFKAFDAKTGEELWKFKTGSGIVGPPVTYEQDGKQYVAVLSGWGG 527
Gcd COG4993
Glucose dehydrogenase, PQQ-dependent [Carbohydrate transport and metabolism];
66-583 0e+00

Glucose dehydrogenase, PQQ-dependent [Carbohydrate transport and metabolism];


Pssm-ID: 444017 [Multi-domain]  Cd Length: 515  Bit Score: 585.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268  66 DANNWLHYGKDYQNTRFSALTQITTDNVKKLVPKWNLSFGVNEAQDSQTT--VVNGRIYVTASQNKVFSLDGVTGKMLWK 143
Cdd:COG4993     1 DPGDWLAYGGDYAGQRYSPLDQINPDNVKKLKVAWTFSTGDLPERGHEATplVVDGVLYVCTPHNRVFALDAATGKELWR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 144 YERSLPGDLGpklCCDAVNRGVAVYKDMVFMATLDTHVVALNNTTGQVVWERKMGDYQTGEIYTSMPLVAKGMVIVGNSG 223
Cdd:COG4993    81 YDPKLPDDAA---CCDVVNRGVAYYDGRIFLGTLDGRLVALDAKTGKVCWDVKVGDPKKGYTITSAPLVVKDKVIVGGSG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 224 GDVGAnVGRITALDPATGNTIWEFKTRPTSADhPQAKTW-ANDSWKTGGGSAWLTGTYDAKTNTVLWGVGNPAPDFDPSV 302
Cdd:COG4993   158 GEFGP-RGVVRAYDARTGKLVWRFDTIPDPGE-PGAETWpPGDTWKRGGGNVWGTMSYDPELGLVYLPTGNPAPDWNGGQ 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 303 RKGDNLYTNSTVALDADTGKIKYHFQYTPNDAWDYDGNNEMILVD---DDKGRKVWLHGDRNGHLYSIDRTNGKCNWVVP 379
Cdd:COG4993   236 RPGDNLYSSSIVALDADTGELKWHYQTVPHDLWDYDGPNEPILVDlpvDGKTRKALVQATKNGFIYVLDRETGEPLVTQP 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 380 IAR-VNWVTGFG-DNCRPIVNPdkvPGYDRIATDIAPILDGGKEWHPAAYSLRTKLVYVPFIDSSMDVQAKKSEWKKGEW 457
Cdd:COG4993   316 FVKpPNWATEIDmWGATPIQTP---PSLDGKTTLICPGALGGKNWGPAAYDPETGLLYVPANELCMDYELVPREYQAGAP 392

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 458 FLSSKVLKA---NPYTGGVKAFNATTGEQVWTRPQSTPATSGLLATAGKLVFSGDAEGYFSALKDDTGEELWRFNVGSGI 534
Cdd:COG4993   393 YLGATLTMYpcpAPPWGTLTAIDLNTGKIVWQVPLGFPNWGGPLATAGGLVFIGTLDGYLRAFDAKTGKELWKFRLPSGG 472

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*....
gi 1566407268 535 HGNPTTFTADGKQYVAIVYGpGGGSLWPLVYdelfkrNNRGGGMMVFGL 583
Cdd:COG4993   473 QATPMTYEVDGKQYVAVAAG-GGGWLGLGLY------TPQGDYLIAFAL 514
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 115-376 9.34e-15

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 73.98  E-value: 9.34e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 115 TVVNGRIYVTASQNKVFSLDGVTGKMLWKYErsLPGDlgpklccdaVNRGVAVYKDMVFMATLDTHVVALNNTTGQVVWE 194
Cdd:pfam13360  30 AVDGGRLFVATGGGQLVALDAATGKLLWRQT--LSGE---------VLGAPLVAGGRVFVVAGDGSLIALDAADGRRLWS 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 195 RKMGDYQTGEIYTSMPLVAKGMVIVGNSGGDVganvgriTALDPATGNTIWEfktRPTSAdhpqaktwandswktgggsa 274
Cdd:pfam13360  99 YQRSGEPLALRSSGSPAVVGDTVVAGFSSGKL-------VALDPATGKVRWE---APLAA-------------------- 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 275 wltgtydAKTNTVLWGVGNPAPdfdPSVRKGDNLYT----NSTVALDADTGKIKYhfqytpndAWDYDGNNEMILVDDdk 350
Cdd:pfam13360 149 -------PRGTNELERLVDITG---TPVVAGGRVFAsayqGRLVAFDAATGRRLW--------TREISGPNGPILDGD-- 208

                         250       260
                  ....*....|....*....|....*..
gi 1566407268 351 grkvWLHGDR-NGHLYSIDRTNGKCNW 376
Cdd:pfam13360 209 ----LLYVVSdDGELYALDRATGAVVW 231
PRK11138 PRK11138
outer membrane biogenesis protein BamB; Provisional
 115-376 1.44e-11

outer membrane biogenesis protein BamB; Provisional


Pssm-ID: 236857 [Multi-domain]  Cd Length: 394  Bit Score: 66.49  E-value: 1.44e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 115 TVVNGRIYVTASQNKVFSLDGVTGKMLWK-----YERSLPGDLGPKLccdavNRGVAVYKDMVFMATLDTHVVALNNTTG 189
Cdd:PRK11138   66 AVAYNKVYAADRAGLVKALDADTGKEIWSvdlseKDGWFSKNKSALL-----SGGVTVAGGKVYIGSEKGQVYALNAEDG 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 190 QVVWERKMGdyqtGEIyTSMPLVAKGMVIVGNSGgdvganvGRITALDPATGNTIWEFKT-------RPTSAdhPQAktw 262
Cdd:PRK11138  141 EVAWQTKVA----GEA-LSRPVVSDGLVLVHTSN-------GMLQALNESDGAVKWTVNLdvpsltlRGESA--PAT--- 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 263 andswkTGGGSAWltGTYDAKTNTVL-------W--GVGNPA--------PDFDPS-VRKGDNLYTNS----TVALDADT 320
Cdd:PRK11138  204 ------AFGGAIV--GGDNGRVSAVLmeqgqliWqqRISQPTgateidrlVDVDTTpVVVGGVVYALAyngnLVALDLRS 275

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1566407268 321 GKIkyhfqytpndAW--DYDGNNEMIlVDDDKGRKVwlhgDRNGHLYSIDRTNGKCNW 376
Cdd:PRK11138  276 GQI----------VWkrEYGSVNDFA-VDGGRIYLV----DQNDRVYALDTRGGVELW 318
 
Name Accession Description Interval E-value
PQQ_ADH_I cd10277
Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); ...
 60-583 0e+00

Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); This bacterial family of homodimeric ethanol dehydrogenases utilize pyrroloquinoline quinone (PQQ) as a cofactor. It represents proteins whose expression may be induced by ethanol, and which are similar to quinoprotein methanol dehydrogenases, but have higher specificities for ethanol and other primary and secondary alcohols. Dehydrogenases with PQQ cofactors, such as ethanol, methanol, and membrane-bound glucose dehydrogenases, form an 8-bladed beta-propeller.


Pssm-ID: 199835 [Multi-domain]  Cd Length: 529  Bit Score: 783.41  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268  60 LLNADKDANNWLHYGKDYQNTRFSALTQITTDNVKKLVPKWNLSFGV-NEAQDSQTTVVNGRIYVTASQNKVFSLDGVTG 138
Cdd:cd10277     1 LLNDAKETGNWLTYGRGYNGQRYSPLKQINTDNVKNLVPAWSFSFGGkQRGQESQPIVNDGVMYVTTSYNRVFAIDAKTG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 139 KMLWKYERSLPGDLGPklCCDAVNRGVAVYKDMVFMATLDTHVVALNNTTGQVVWERKMGDYQTGEIYTSMPLVAKGMVI 218
Cdd:cd10277    81 KELWKYKHRLPEDIRP--CCDVVNRGVALYGDKVYFGTLDAHLVALDAKTGKVVWKKKVADYKAGYSMTLAPLVVKGKVI 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 219 VGNSGGDVGaNVGRITALDPATGNTIWEFKTRPTSADHPQAKTWANDSWKTGGGSAWLTGTYDAKTNTVLWGVGNPAPDF 298
Cdd:cd10277   159 VGVSGGEFG-VRGFIAALDAETGKEVWRTYTVPGPGEPGSTDTWPGDAWKTGGGATWLTGTYDPETNLLYWGVGNPAPWN 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 299 DPsVRKGDNLYTNSTVALDADTGKIKYHFQYTPNDAWDYDGNNEMILVD---DDKGRKVWLHGDRNGHLYSIDRTNGKCN 375
Cdd:cd10277   238 GD-LRPGDNLYTSSVLALDPDTGKIKWHYQYTPNDTWDYDGVNEPVLFDytkNGKPVKALVHADRNGFFYVLDRTNGKLI 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 376 WVVPIARVNWVT-GFGDNCRPIVNPDKVPGYDRIATDIAPILDGGKEWHPAAYSLRTKLVYVPFIDSSMDVQAKKSEWKK 454
Cdd:cd10277   317 WATPFVKKITWAsIDLKTGRPIYDEDKVPPKKGKTVDFCPSFLGGKNWPPMAYSPDTGLFYVPANHWCMDLTGEPVSYKK 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 455 GEWFLSSKVLK---ANPYTGGVKAFNATTGEQVWTRPQSTPATSGLLATAGKLVFSGDAEGYFSALKDDTGEELWRFNVG 531
Cdd:cd10277   397 GAAYLGAGFTIkppFEDHIGELQAIDPTTGKKVWEHKTPLPLWGGVLTTAGGLVFTGTPDGYFRAFDAKTGKELWEFQTG 476

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1566407268 532 SGIHGNPTTFTADGKQYVAIVYGPGGGSLWPLVYDE-LFKRNNRGGGMMVFGL 583
Cdd:cd10277   477 SGIIGPPVTWEVDGKQYVAVLSGWGGAAPLWGGDMAkLLKNVPQGGSLWVFAL 529
PQQ_enz_alc_DH TIGR03075
PQQ-dependent dehydrogenase, methanol/ethanol family; This protein family has a phylogenetic ...
 55-557 0e+00

PQQ-dependent dehydrogenase, methanol/ethanol family; This protein family has a phylogenetic distribution very similar to that coenzyme PQQ biosynthesis enzymes, as shown by partial phylogenetic profiling. Genes in this family often are found adjacent to the PQQ biosynthesis genes themselves. An unusual, strained disulfide bond between adjacent Cys residues contributes to PQQ-binding, as does a Trp residue that is part of a PQQ enzyme repeat (see pfam01011). Characterized members include the dehydrogenase subunit of a membrane-anchored, three subunit alcohol (ethanol) dehydrogenase of Gluconobacter suboxydans, a homodimeric ethanol dehydrogenase in Pseudomonas aeruginosa, and the large subunit of an alpha2/beta2 heterotetrameric methanol dehydrogenase in Methylobacterium extorquens.


Pssm-ID: 274419 [Multi-domain]  Cd Length: 527  Bit Score: 591.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268  55 VSNDMLLNADKDANNWLHYGKDYQNTRFSALTQITTDNVKKLVPKWNLSFGVNEAQDSQTTVVNGRIYVTASQNKVFSLD 134
Cdd:TIGR03075   6 VTNEDLLNDAKDPSDWLTYGGGYAGQRYSPLDQINTDNVKKLQPAWTFSLGKQRGQESQPLVVDGVMYVTTSYSRVYALD 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 135 GVTGKMLWKYERSLPGDLGPKLCCDAVNRGVAVYKDMVFMATLDTHVVALNNTTGQVVWERKMGDYQTGEIYTSMPLVAK 214
Cdd:TIGR03075  86 AKTGKILWKYDPKLPDDIIPVMCCDVVNRGAALYDGKVFFGTLDARLVALDAKTGKVVWSKKNGDYKKGYTITAAPLVVK 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 215 GMVIVGNSGGDVGAnVGRITALDPATGNTIW------------EFKTRPTSADhPQAKTWANDSWKTGGGSAWLTGTYDA 282
Cdd:TIGR03075 166 GKVITGISGGEFGV-RGYVTAYDAKTGKLVWrrytvpgdmgylKKTGKPVGGD-PGAKTWPGDAWKTGGGATWGTGSYDP 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 283 KTNTVLWGVGNPAPdFDPSVRKGDNLYTNSTVALDADTGKIKYHFQYTPNDAWDYDGNNEMILVD---DDKGRKVWLHGD 359
Cdd:TIGR03075 244 ETNLIYFGTGNPAP-WNSHLRPGDNLYTSSIVARDPDTGKIKWHYQTTPHDEWDYDGVNEMILFDlkkDGKPRKLLAHAD 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 360 RNGHLYSIDRTNGKCNWVVP-IARVNWVTGF-GDNCRPIVNPDKVP--GYDRIATDIAPILDGGKEWHPAAYSLRTKLVY 435
Cdd:TIGR03075 323 RNGFFYVLDRTNGKLLSAEPfVDKVNWATGVdLKTGRPIEVPEARStdGKKGKPVEVCPGFLGGKNWQPMAYSPKTGLFY 402

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 436 VPFIDSSMDVQAKKSEWKKGEWFL----SSKVLKaNPYTGGVKAFNATTGEQVWTRPQSTPATSGLLATAGKLVFSGDAE 511
Cdd:TIGR03075 403 VPANHVCMDYWPEKVSYKKGAAYLgagfTIKPPP-DDHIGSLIAWDPITGKIVWEHKEDFPLWGGVLATAGDLVFTGTLE 481

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 1566407268 512 GYFSALKDDTGEELWRFNVGSGIHGNPTTFTADGKQYVAIVYGPGG 557
Cdd:TIGR03075 482 GYFKAFDAKTGEELWKFKTGSGIVGPPVTYEQDGKQYVAVLSGWGG 527
Gcd COG4993
Glucose dehydrogenase, PQQ-dependent [Carbohydrate transport and metabolism];
66-583 0e+00

Glucose dehydrogenase, PQQ-dependent [Carbohydrate transport and metabolism];


Pssm-ID: 444017 [Multi-domain]  Cd Length: 515  Bit Score: 585.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268  66 DANNWLHYGKDYQNTRFSALTQITTDNVKKLVPKWNLSFGVNEAQDSQTT--VVNGRIYVTASQNKVFSLDGVTGKMLWK 143
Cdd:COG4993     1 DPGDWLAYGGDYAGQRYSPLDQINPDNVKKLKVAWTFSTGDLPERGHEATplVVDGVLYVCTPHNRVFALDAATGKELWR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 144 YERSLPGDLGpklCCDAVNRGVAVYKDMVFMATLDTHVVALNNTTGQVVWERKMGDYQTGEIYTSMPLVAKGMVIVGNSG 223
Cdd:COG4993    81 YDPKLPDDAA---CCDVVNRGVAYYDGRIFLGTLDGRLVALDAKTGKVCWDVKVGDPKKGYTITSAPLVVKDKVIVGGSG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 224 GDVGAnVGRITALDPATGNTIWEFKTRPTSADhPQAKTW-ANDSWKTGGGSAWLTGTYDAKTNTVLWGVGNPAPDFDPSV 302
Cdd:COG4993   158 GEFGP-RGVVRAYDARTGKLVWRFDTIPDPGE-PGAETWpPGDTWKRGGGNVWGTMSYDPELGLVYLPTGNPAPDWNGGQ 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 303 RKGDNLYTNSTVALDADTGKIKYHFQYTPNDAWDYDGNNEMILVD---DDKGRKVWLHGDRNGHLYSIDRTNGKCNWVVP 379
Cdd:COG4993   236 RPGDNLYSSSIVALDADTGELKWHYQTVPHDLWDYDGPNEPILVDlpvDGKTRKALVQATKNGFIYVLDRETGEPLVTQP 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 380 IAR-VNWVTGFG-DNCRPIVNPdkvPGYDRIATDIAPILDGGKEWHPAAYSLRTKLVYVPFIDSSMDVQAKKSEWKKGEW 457
Cdd:COG4993   316 FVKpPNWATEIDmWGATPIQTP---PSLDGKTTLICPGALGGKNWGPAAYDPETGLLYVPANELCMDYELVPREYQAGAP 392

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 458 FLSSKVLKA---NPYTGGVKAFNATTGEQVWTRPQSTPATSGLLATAGKLVFSGDAEGYFSALKDDTGEELWRFNVGSGI 534
Cdd:COG4993   393 YLGATLTMYpcpAPPWGTLTAIDLNTGKIVWQVPLGFPNWGGPLATAGGLVFIGTLDGYLRAFDAKTGKELWKFRLPSGG 472

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*....
gi 1566407268 535 HGNPTTFTADGKQYVAIVYGpGGGSLWPLVYdelfkrNNRGGGMMVFGL 583
Cdd:COG4993   473 QATPMTYEVDGKQYVAVAAG-GGGWLGLGLY------TPQGDYLIAFAL 514
PQQ_MDH cd10278
Large subunit of methanol dehydrogenase (moxF); Methanol dehydrogenase is a key enzyme in the ...
 70-583 1.86e-158

Large subunit of methanol dehydrogenase (moxF); Methanol dehydrogenase is a key enzyme in the utilization of C1 compounds as a source of energy and carbon by bacteria. It catalyzes the oxidation of methanol to formaldehyde, transfering two electrons per methanol to cytochrome c(L) as the acceptor. Methanol dehydrogenase belongs to a family of dehydrogenases with pyrroloquinoline quinone (PQQ) as cofactor, which also includes dehydrogenases specific to other alcohols and membrane-bound glucose dehydrogenases. This alignment model for the large subunit contains an 8-bladed beta-propeller; the functional enzyme forms a heterotetramer composed of two large and two small subunits.


Pssm-ID: 199836 [Multi-domain]  Cd Length: 553  Bit Score: 464.49  E-value: 1.86e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268  70 WLHYGKDYQNTRFSALTQITTDNVKKLVPKWNLSFGVNEAQDSQTTVVNGRIYV-TASQNKVFSLD-GVTGKMLWKYERS 147
Cdd:cd10278     1 WVMPGKDYANTRYSPLAQINKDNVKNLKVAWTFSTGVLRGHEGAPLVVGDTMYVvTPFPNNVYALDlNDPGKILWKYKPK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 148 LPGDLGPKLCCDAVNRGVAVYKDMVFMATLDTHVVALNNTTGQVVWERKMGDYQTGEIYTSMPLVAKGMVIVGNSGGDVG 227
Cdd:cd10278    81 QDPSAVAVACCDVVNRGLAYADGKIFFNQLDGHLVALDAKTGKEVWKVKNGDPKVGETLTMAPLVVKDKVIVGISGGEFG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 228 ANvGRITALDPATGNTIWE-FKTRP---------TSADHPQ-------AKTWANDSWKTGGGSAWLTGTYDAKTNTVLWG 290
Cdd:cd10278   161 VR-GYVTAYDLKTGKLVWRaYSTGPdkdvligpdFNPFNPHdggkdlgLSTWPGDAWKIGGGTNWGWYSYDPKLNLVYYG 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 291 VGNPAPdFDPSVRKGDNLYTNSTVALDADTGKIKYHFQYTPNDAWDYDGNNEMILVD---DDKGRKVWLHGDRNGHLYSI 367
Cdd:cd10278   240 TGNPGP-WNPTQRPGDNKWSMTIFARDPDTGEAKWAYQMTPHDEWDYDGVNEMILVDqtvDGKKRKLLVHFDRNGFVYTL 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 368 DRTNGKCNWVVPIARVNWVTGFG-DNCRPIVNPDKVPGYDRIATDIAPILDGGKEWHPAAYSLRTKLVYVPFIDSSMDVQ 446
Cdd:cd10278   319 DRTTGELLSAEKFDPVNNWKGVDlKTGRPVKDPEKSTHMDHNVTDICPSAMGGKDQQPSSYSPKTGLFYVPTNHLCMDYE 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 447 AKKSEWKKGEWFLSSKV-LKANP--YTGGVKAFNATTGEQVWTRPQSTPATSGLLATAGKLVFSGDAEGYFSALKDDTGE 523
Cdd:cd10278   399 PFEVNYTAGQPYVGATLaMYPGPggHMGQFKAWDPVTGKTKWEIKERFPVWSGTLATAGGLVFYGTLDGWFKAVDAKTGK 478

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1566407268 524 ELWRFNVGSGIHGNPTTFTADGKQYVAIVYGPGGGSLWPLVYD---------------ELFKRNNRGGGMMVFGL 583
Cdd:cd10278   479 LLWKFKLPSGIIGNPITYKHDGKQYVAVLSGVGGWAGVGVAAGlrdptaglgavgafkDLPNYTQMGGTLYVFSL 553
PQQ_ADH_II cd10279
PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); This family of ...
 69-583 3.53e-145

PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); This family of monomeric and soluble type II alcohol dehydrogenases utilizes pyrroloquinoline quinone (PQQ) as a cofactor and is related to ethanol, methanol, and membrane-bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller.


Pssm-ID: 199837 [Multi-domain]  Cd Length: 549  Bit Score: 430.53  E-value: 3.53e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268  69 NWLHYGKDYQNTRFSALTQITTDNVKKLVPKWNLSFGVNEAQDSQTTVVNGRIYVTASQNKVFSLDGVTGKMLWKYERSL 148
Cdd:cd10279     2 NWLSYGRDYDEQRFSPLTQINRSNVGQLGLAWYFDLDTNRGQEATPLVVDGVMYVSGPWSVVYALDARTGKLLWQYDPEV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 149 PGDLGPKLCCDAVNRGVAVYKDMVFMATLDTHVVALNNTTGQVVWERKMGDYQTGEIYTSMPLVAKGMVIVGNSGGDVGA 228
Cdd:cd10279    82 DRESGRKACCDVVNRGVAVWDGKVFVGTLDGRLIALDAKTGKEVWSVDTIDPRKPYTITGAPRVAKGKVVIGNGGAEFGV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 229 NvGRITALDPATGNTIWEFKTRPTSADHP---------QAKTWANDSWKTG-GGSAWLTGTYDAKTNTVLWGVGNPAPdF 298
Cdd:cd10279   162 R-GYVSAYDAETGKLVWRFYTVPGNPAKPfehasleaaAATWWTGEWWRTGgGGTVWDSITYDPELDLLYIGTGNGSP-W 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 299 DPSVR---KGDNLYTNSTVALDADTGKIKYHFQYTPNDAWDYDGNNEMILVD---DDKGRKVWLHGDRNGHLYSIDRTNG 372
Cdd:cd10279   240 NRKVRspgGGDNLFLSSIVALDADTGRYKWHYQTTPGDTWDYTATQPIILADleiDGKPRKVLMHAPKNGFFYVLDRATG 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 373 KCNWVVPIARVNWVTGF-GDNCRPIVNPDKvpGYDRIATDIAPILDGGKEWHPAAYSLRTKLVYVPFIDSSMDVQAKKSE 451
Cdd:cd10279   320 KLLSAEPFVPVNWATGIdLKTGRPIENPEA--RYTKGPKLVFPGPLGAHNWHPMSYNPDTGLVYIPAQEIPAVYEDDPGD 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 452 WKKGEWF------LSSKVLKANPY-------TGGVKAFNATTGEQVWTRPQSTPATSGLLATAGKLVFSGDAEGYFSALK 518
Cdd:cd10279   398 FGYNPLGwntgitPDATPPPAAAKralrkatRGRLVAWDPVTQKAAWRVEHPGPWNGGVLATAGNLVFQGTADGELAAYD 477

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1566407268 519 DDTGEELWRFNVGSGIHGNPTTFTADGKQYVAIVYGPGG--GSLWPLVYDELFKRNNrgGGMMVFGL 583
Cdd:cd10279   478 ARTGEKLWSFDTGSGIVAAPMTYSVDGEQYVAVLAGWGGagALSGGPPGAAGKVQNP--GRLLVFKL 542
PQQ_DH_like cd00216
PQQ-dependent dehydrogenases and related proteins; This family is composed of dehydrogenases ...
 91-581 3.27e-104

PQQ-dependent dehydrogenases and related proteins; This family is composed of dehydrogenases with pyrroloquinoline quinone (PQQ) as a cofactor, such as ethanol, methanol, and membrane-bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller, and the family also includes distantly related proteins which are not enzymatically active and do not bind PQQ.


Pssm-ID: 199833 [Multi-domain]  Cd Length: 434  Bit Score: 321.48  E-value: 3.27e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268  91 DNVKKLVPKWNLSFGV--NEAQDSQTTVVNGRIYVTASQNKVFSLDGVTGKMLWKYERSLPGDLGPKlCCDAVNRGVAVY 168
Cdd:cd00216     2 DNVFQLTPAWSFSTGDggNRGSELTPIVVDGVMYATTSFSRVFALDADDGKEIWSYDPALKDGWFEA-CCDLVNRGVAVW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 169 KDMVFMATLDTHVVALNNTTGQVVWERKMGDYQTGEIYTSMPLVAKGMVIVGNSGGDVGAnVGRITALDPATGNTIWEFK 248
Cdd:cd00216    81 GGKVYIGVLDGRVYALNAETGKVAWKVKNADVLGGYTATSAPVVVDGLVIIGSSGDEFGV-RGYLTAYDVATGEEKWRFY 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 249 TRPTSADHPQAK----------TWANDSWKTGGGSAWLTGTYDAKTNTVLWGVGNPAP-DFDPSVRKGDNLYTNSTVALD 317
Cdd:cd00216   160 LVMPDPNLLPGKdstvtdrntpTGDEHTWTSGGGTGWSSAAYDAELNLIYVGGGNPTPwNWGGNRTPGDNLYTSSIVAVN 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 318 ADTGKIKYHFQYTPNDAWDYDGNNEMILVD---DDKGRKVWLHGDRNGHLYSIDRTNGKCNWVVPIArvnwvtgfgdncr 394
Cdd:cd00216   240 ADTGEMKWQYQTTPHDAWDYDGDNTPVLADikvKGKKVKVLFAPAKNGNFYVLDRRNGELVSARPLV------------- 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 395 pivnpdkvpgydriatdiapildggkewhPAAYSLRTKLVYVPfidssmdvqakksewkkgewflsskvlkANpytGGVK 474
Cdd:cd00216   307 -----------------------------PDSYDPDRELFYVP----------------------------AN---GRIM 326

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 475 AFNATTGEQVWTRPQSTPATSGLLATAGKLVFSGDAEGYFSALKDDTGEELWRFNVGSGIHGNPTTFTADGKQYVAIVYG 554
Cdd:cd00216   327 ALDPVTGVVVWEKSELHPLLGGPLSTAGNLVFVGTSDGYLKAYNADTGEKLWQQKVPSGFQAEPVTYEVDGEQYVLIQAG 406

                         490       500
                  ....*....|....*....|....*..
gi 1566407268 555 PGGGSLWPLVYDELFKRNNRGGGMMVF 581
Cdd:cd00216   407 GGGAFPLWGGMADLTRGTQMGGTVVVY 433
PQQ_mGDH cd10280
Membrane-bound PQQ-dependent glucose dehydrogenase; This bacterial subfamily of enzymes ...
 70-568 1.57e-78

Membrane-bound PQQ-dependent glucose dehydrogenase; This bacterial subfamily of enzymes belongs to the dehydrogenase family with pyrroloquinoline quinone (PQQ) as cofactor, and is the only subfamily that is bound to the membrane. Glucose dehydrogenase converts D-glucose to D-glucono-1,5-lactone in a reaction that is coupled with the respiratory chain in the periplasmic oxidation of sugars and alcohols in gram-negative bacteria. Ubiquinone functions as the electron acceptor. The alignment model contains an 8-bladed beta-propeller.


Pssm-ID: 199838 [Multi-domain]  Cd Length: 616  Bit Score: 259.82  E-value: 1.57e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268  70 WLHYGKDYQNTRFSALTQITTDNVKKLVPKW------NLSFGVNEAQDsQTT--VVNGRIYVTASQNKVFSLDGVTGKML 141
Cdd:cd10280     1 WPAYGGDPGGTRYSPLDQITPDNVGKLKVAWtyhtgdLPGPDGNEGTF-EATplKVGGTLYLCTPHNRVIALDAATGKEL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 142 WKYERSLPGDLGPKLccdAVNRGVAVYKD---------MVFMATLDTHVVALNNTTGQVVWE----------RKMGDYQT 202
Cdd:cd10280    80 WRFDPKAGADAAPGH---QTCRGVSYWEDgaaaaacarRIFFGTGDARLIALDARTGKPCPDfgdngvvdlrEGLGRVKP 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 203 GEIY-TSMPLVAKGMVIVGNSGGD---VGANVGRITALDPATGNTIWEFKTRPTSADHPQAktwANDSWKT-GGGSAWLT 277
Cdd:cd10280   157 GFYSsTSPPTVYGDLVIVGSAVADnqaVDAPSGVIRAFDVRTGKLVWAFDTIPPPGEAGPD---TAGAWYTrGGPNVWAG 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 278 GTYDAKTNTVLWGVGNPAPDFDPSVRKGDNLYTNSTVALDADTGKIKYHFQYTPNDAWDYDGNNEMILVD---DDKGRKV 354
Cdd:cd10280   234 MSADEKLGLVYLPTGSATPDFYGGDRPGDNLFANSLVALDAATGKRRWHFQTVHHDLWDYDLPAQPTLVDvprDGKTVPA 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 355 WLHGDRNGHLYSIDRTNGKCNWVV--------------------------PIARVN------W-VTGFG-DNCR------ 394
Cdd:cd10280   314 VAQPTKQGFVFVLDRRTGKPLWPVeerpvpqgdvpgertsptqpfptlppPFARQGlteddmWgATPFDqLACRiqfrsl 393

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 395 ---PIVNPdkvPGYDRiaTDIAPILDGGKEWHPAAYSLRTKLVYV-----PFI--------DSSMDVQAKKSEWKKG--- 455
Cdd:cd10280   394 ryeGLFTP---PSLDG--TLIFPGNDGGANWGGAAVDPERGILYVnsnrlPFViqlvprapGDPAGVAGGGEGGGGGggp 468

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 456 ------------EWFLSSKVLKAN--PYtGGVKAFNATTGEQVWTRP-----------------QSTPATSGLLATAGKL 504
Cdd:cd10280   469 spqagtpygvgrGRFLSPLGLPCQapPW-GTLTAIDLNTGKILWQVPlgtvpdlgpkgiplpipTGTPNLGGPVVTAGGL 547

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1566407268 505 VF-SGDAEGYFSALKDDTGEELWRFNVGSGIHGNPTTFTADGKQYVAIVYGpGGGSLWPLVYDEL 568
Cdd:cd10280   548 VFiAATQDNYLRAFDKATGKELWEARLPAGGQATPMTYEVDGKQYVVIAAG-GHGSLGTKRGDSV 611
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 83-376 5.03e-17

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 82.94  E-value: 5.03e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268  83 SALTQITtdNVKKLVPKWNLSFG-VNEAQDS--QTTVVNGRIYVTASQNKVFSLDGVTGKMLWKYerslpgDLGpklccD 159
Cdd:COG1520    21 APLPEFE--PSVKVKQLWSASVGdGVGKGYSrlAPAVAGDRVYAADADGRVAALDAATGKELWRV------DLG-----E 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 160 AVNRGVAVYKDMVFMATLDTHVVALNNTTGQVVWERKMgdyqTGEIYTSmPLVAKGMVIVgnSGGDvganvGRITALDPA 239
Cdd:COG1520    88 PLSGGVGADGGLVVVGTEDGEVIALDADDGEELWRARL----SSEVLAA-PAVAGGRVVV--RTGD-----GRVYALDAA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 240 TGNTIWEFKT-------RPTSAdhPQAktwANDSWKTGGGSAWLTGtYDAKTNTVLW--GVGNP--APDFD-------PS 301
Cdd:COG1520   156 TGERLWSYQRpvpaltlRGTSS--PVI---VGGAVLVGFANGKLVA-LDLANGQPLWeqRVAQPrgRTELErlvdvdgTP 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 302 VRKGDNLYTNS----TVALDADTGKIkyhfqytpndAW--DYDGNNEMiLVDddkGRKVWLhGDRNGHLYSIDRTNGKCN 375
Cdd:COG1520   230 VVDGGVVYAVAyqgrLAALDLRSGRV----------LWsrDLSSYTGL-AVD---GNNLYV-TDDDGRVWALDRRNGAEL 294


                  .
gi 1566407268 376 W 376
Cdd:COG1520   295 W 295
BamB_YfgL cd10276
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ...
 88-380 1.03e-15

Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.


Pssm-ID: 199834 [Multi-domain]  Cd Length: 358  Bit Score: 78.91  E-value: 1.03e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268  88 ITTDNVKKLvpkWNLSFGVNEAQDSQTT--VVNGRIYVTASQNKVFSLDGVTGKMLWKYERSLPGDLGPklccdavnrGV 165
Cdd:cd10276     9 TPEFDPEVL---WSKSVGNGGMAGIDLTpvVAGDMVYAADANGQVSAFNATTGKIIWETSLSGKGFLGG---------TP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 166 AVYKDMVFMATLDTHVVALNNTTGQVVWERKMGDyqtGEIYTSmPLVAKGMVIVGNSGgdvganvGRITALDPATGNTIW 245
Cdd:cd10276    77 AVGNGKIFVGTESGYLYALDAKDGSELWRTEVSD---SQLLSP-PTYADGKIYVGTGD-------GRLYYCNAETGKVVW 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 246 EFKTRPTSADHPQAKTWANDSWKTGGGSAWLTGTY-DAKTNTVLW--GVGNPAP------DFDPS---VRKGDNLYTNS- 312
Cdd:cd10276   146 NRTSTAPELSLRGGAAPVGAYDVVFVGDGNGTVVAlNTGTGVDIWefSVSEPRGrtelprMIDSSvtyVVVGGYLYSTSy 225

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1566407268 313 ---TVALDADTGKIkyhfqytpNDAWDYDGNNEMILvdDDKGRkVWLhGDRNGHLYSIDRTNGKCNWVVPI 380
Cdd:cd10276   226 qgyLVALDFESGQF--------LWSRKASGGTSTST--DANGR-VYV-GDGEGSLYCLDASTGDELWSQTV 284
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 115-376 9.34e-15

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 73.98  E-value: 9.34e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 115 TVVNGRIYVTASQNKVFSLDGVTGKMLWKYErsLPGDlgpklccdaVNRGVAVYKDMVFMATLDTHVVALNNTTGQVVWE 194
Cdd:pfam13360  30 AVDGGRLFVATGGGQLVALDAATGKLLWRQT--LSGE---------VLGAPLVAGGRVFVVAGDGSLIALDAADGRRLWS 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 195 RKMGDYQTGEIYTSMPLVAKGMVIVGNSGGDVganvgriTALDPATGNTIWEfktRPTSAdhpqaktwandswktgggsa 274
Cdd:pfam13360  99 YQRSGEPLALRSSGSPAVVGDTVVAGFSSGKL-------VALDPATGKVRWE---APLAA-------------------- 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 275 wltgtydAKTNTVLWGVGNPAPdfdPSVRKGDNLYT----NSTVALDADTGKIKYhfqytpndAWDYDGNNEMILVDDdk 350
Cdd:pfam13360 149 -------PRGTNELERLVDITG---TPVVAGGRVFAsayqGRLVAFDAATGRRLW--------TREISGPNGPILDGD-- 208

                         250       260
                  ....*....|....*....|....*..
gi 1566407268 351 grkvWLHGDR-NGHLYSIDRTNGKCNW 376
Cdd:pfam13360 209 ----LLYVVSdDGELYALDRATGAVVW 231
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 116-376 1.17e-14

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 75.74  E-value: 1.17e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 116 VVNGRIYVTASQNKVFSLDGVTGKMLWKyerslpGDLGPKLccdavNRGVAVYKDMVFMATLDTHVVALNNTTGQVVWER 195
Cdd:TIGR03300  63 VAGGKVYAADADGTVAALDAETGKRLWR------VDLDERL-----SGGVGADGGLVFVGTEKGEVIALDAEDGKELWRA 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 196 KMgdyqTGEIyTSMPLVAKGMVIVgnSGGDvganvGRITALDPATGNTIWEFKTrptsadHPQAKTWANDSWKTGGGSAW 275
Cdd:TIGR03300 132 KL----SSEV-LSPPLVANGLVVV--RTND-----GRLTALDAATGERLWTYSR------VTPPLTLRGSASPVIADGGV 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 276 LTGT-------YDAKTNTVLW--GVGNPAP----------DFDPSVRkGDNLYT----NSTVALDADTGKIkyhfqytpn 332
Cdd:TIGR03300 194 LVGFaggklvaLDLQTGQPLWeqRVALPKGrtelerlvdvDGDPVVD-GGQVYAvsyqGRVAALDLRSGRV--------- 263

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1566407268 333 dAW--DYDGNNEMiLVDDdkgRKVWLhGDRNGHLYSIDRTNGKCNW 376
Cdd:TIGR03300 264 -LWkrDASSYQGP-AVDD---NRLYV-TDADGVVVALDRRSGSELW 303
BamB_YfgL cd10276
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ...
 166-533 2.38e-12

Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.


Pssm-ID: 199834 [Multi-domain]  Cd Length: 358  Bit Score: 68.51  E-value: 2.38e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 166 AVYKDMVFMATLDTHVVALNNTTGQVVWERKMGDyqtGEIYTSMPLVAKGMVIVGNSGGDvganvgrITALDPATGNTIW 245
Cdd:cd10276    35 VVAGDMVYAADANGQVSAFNATTGKIIWETSLSG---KGFLGGTPAVGNGKIFVGTESGY-------LYALDAKDGSELW 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 246 -------EFKTRPTSADhpqaktwandswktgggsawltgtydaktNTVLWGVGNpapdfdpsvrkgdnlytNSTVALDA 318
Cdd:cd10276   105 rtevsdsQLLSPPTYAD-----------------------------GKIYVGTGD-----------------GRLYYCNA 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 319 DTGKIKYHFQYTPND-------AWDYDGNNEMIlvdddkgrkvwlhGDRNGHLYSIDRTNGKCNWVVPIARVNWVTgfgd 391
Cdd:cd10276   139 ETGKVVWNRTSTAPElslrggaAPVGAYDVVFV-------------GDGNGTVVALNTGTGVDIWEFSVSEPRGRT---- 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 392 ncrpivnpdKVPGYDRIatDIAPILDGGKewhpaAYSLRtklvyvpfidssmdvqakksewkkgewflsskvlkanpYTG 471
Cdd:cd10276   202 ---------ELPRMIDS--SVTYVVVGGY-----LYSTS--------------------------------------YQG 227

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1566407268 472 GVKAFNATTGEQVWTRPQStpATSGLLATAGKLVFSGDAEGYFSALKDDTGEELWRFNVGSG 533
Cdd:cd10276   228 YLVALDFESGQFLWSRKAS--GGTSTSTDANGRVYVGDGEGSLYCLDASTGDELWSQTVLLG 287
PRK11138 PRK11138
outer membrane biogenesis protein BamB; Provisional
 115-376 1.44e-11

outer membrane biogenesis protein BamB; Provisional


Pssm-ID: 236857 [Multi-domain]  Cd Length: 394  Bit Score: 66.49  E-value: 1.44e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 115 TVVNGRIYVTASQNKVFSLDGVTGKMLWK-----YERSLPGDLGPKLccdavNRGVAVYKDMVFMATLDTHVVALNNTTG 189
Cdd:PRK11138   66 AVAYNKVYAADRAGLVKALDADTGKEIWSvdlseKDGWFSKNKSALL-----SGGVTVAGGKVYIGSEKGQVYALNAEDG 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 190 QVVWERKMGdyqtGEIyTSMPLVAKGMVIVGNSGgdvganvGRITALDPATGNTIWEFKT-------RPTSAdhPQAktw 262
Cdd:PRK11138  141 EVAWQTKVA----GEA-LSRPVVSDGLVLVHTSN-------GMLQALNESDGAVKWTVNLdvpsltlRGESA--PAT--- 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 263 andswkTGGGSAWltGTYDAKTNTVL-------W--GVGNPA--------PDFDPS-VRKGDNLYTNS----TVALDADT 320
Cdd:PRK11138  204 ------AFGGAIV--GGDNGRVSAVLmeqgqliWqqRISQPTgateidrlVDVDTTpVVVGGVVYALAyngnLVALDLRS 275

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1566407268 321 GKIkyhfqytpndAW--DYDGNNEMIlVDDDKGRKVwlhgDRNGHLYSIDRTNGKCNW 376
Cdd:PRK11138  276 GQI----------VWkrEYGSVNDFA-VDGGRIYLV----DQNDRVYALDTRGGVELW 318
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 115-246 3.95e-10

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 61.87  E-value: 3.95e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 115 TVVNGRIYVTASQNKVFSLDGVTGKMLWKyeRSLPGD-LGPklccdavnrgVAVYKDMVFMATLDTHVVALNNTTGQVVW 193
Cdd:TIGR03300 102 GADGGLVFVGTEKGEVIALDAEDGKELWR--AKLSSEvLSP----------PLVANGLVVVRTNDGRLTALDAATGERLW 169

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1566407268 194 erkmgDYQTGEIY-----TSMPLVAKGMVIVGNSGgdvganvGRITALDPATGNTIWE 246
Cdd:TIGR03300 170 -----TYSRVTPPltlrgSASPVIADGGVLVGFAG-------GKLVALDLQTGQPLWE 215
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 190-527 5.19e-10

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 61.37  E-value: 5.19e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 190 QVVWERKMGDYQTGEIYTSMPLVAKGMVIVGNSGGDVganvgriTALDPATGNTIWEFKT-RPTSAdhpqaktwandswk 268
Cdd:COG1520    33 KQLWSASVGDGVGKGYSRLAPAVAGDRVYAADADGRV-------AALDAATGKELWRVDLgEPLSG-------------- 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 269 tG---GGSAWLTGT-------YDAKTNTVLWGVGNPAPDFDPSVRKGDNLYTNST----VALDADTGKIKyhfqytpnda 334
Cdd:COG1520    92 -GvgaDGGLVVVGTedgeviaLDADDGEELWRARLSSEVLAAPAVAGGRVVVRTGdgrvYALDAATGERL---------- 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 335 WDYD---------GNNEMILVDDdkgrkVWLHGDRNGHLYSIDRTNGKCNWVVPIARvnwvtgfgdncrpivnPDKVPGY 405
Cdd:COG1520   161 WSYQrpvpaltlrGTSSPVIVGG-----AVLVGFANGKLVALDLANGQPLWEQRVAQ----------------PRGRTEL 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 406 DRIAtDI--APILDGGkewhpaayslrtkLVYVpfidSSmdvqakksewkkgewflsskvlkanpYTGGVKAFNATTGEQ 483
Cdd:COG1520   220 ERLV-DVdgTPVVDGG-------------VVYA----VA--------------------------YQGRLAALDLRSGRV 255

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1566407268 484 VWTRPQSTPATsglLATAGKLVFSGDAEGYFSALKDDTGEELWR 527
Cdd:COG1520   256 LWSRDLSSYTG---LAVDGNNLYVTDDDGRVWALDRRNGAELWK 296
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 188-527 2.74e-09

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 59.18  E-value: 2.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 188 TGQVVWERKMGDYQTGEIYTSMPLVAKGMVIVgnSGGDvganvGRITALDPATGNTIWE--FKTRPTSAdhpqaktwand 265
Cdd:TIGR03300  39 KVDQVWSASVGDGVGHYYLRLQPAVAGGKVYA--ADAD-----GTVAALDAETGKRLWRvdLDERLSGG----------- 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 266 swKTGGGSAWLTGTY-------DAKTNTVLWGVGNPAPDFDPSVRKGDNLYTNST----VALDADTGKIKyhfqytpnda 334
Cdd:TIGR03300 101 --VGADGGLVFVGTEkgevialDAEDGKELWRAKLSSEVLSPPLVANGLVVVRTNdgrlTALDAATGERL---------- 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 335 WDYD---------GNNEMILVDDdkgrkVWLHGDRNGHLYSIDRTNGKCNWVVPIArvnwvtgfgdncrpivNPDKVPGY 405
Cdd:TIGR03300 169 WTYSrvtppltlrGSASPVIADG-----GVLVGFAGGKLVALDLQTGQPLWEQRVA----------------LPKGRTEL 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 406 DRIaTDI--APILDGGkewhpaayslrtklvyvpfidssmdvqakksewkkgewflsskVLKANPYTGGVKAFNATTGEQ 483
Cdd:TIGR03300 228 ERL-VDVdgDPVVDGG-------------------------------------------QVYAVSYQGRVAALDLRSGRV 263

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1566407268 484 VWTRPQSTPATsglLATAGKLVFSGDAEGYFSALKDDTGEELWR 527
Cdd:TIGR03300 264 LWKRDASSYQG---PAVDDNRLYVTDADGVVVALDRRSGSELWK 304
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 231-527 8.46e-09

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 56.26  E-value: 8.46e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 231 GRITALDPATGNTIWEFK-TRPTSADHPQAKTWAndswKTGGGSAWLTGtYDAKTNTVLW-------GVGNPAPDFDPS- 301
Cdd:pfam13360   3 GVVTALDAATGAELWRVDlETGLGGGVAVDGGRL----FVATGGGQLVA-LDAATGKLLWrqtlsgeVLGAPLVAGGRVf 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 302 VRKGDNLYTnstvALDADTGKIKYHFQyTPNDAWDYDGNNEMILVDDdkgrKVWLHGDRnGHLYSIDRTNGKCNWVVPIA 381
Cdd:pfam13360  78 VVAGDGSLI----ALDAADGRRLWSYQ-RSGEPLALRSSGSPAVVGD----TVVAGFSS-GKLVALDPATGKVRWEAPLA 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 382 RvnwvtgfgdncrpivnpdkvpgyDRIATDIAPILDggkewhpaayslrtkLVYVPFIDSSmdvqakksewkkgewflss 461
Cdd:pfam13360 148 A-----------------------PRGTNELERLVD---------------ITGTPVVAGG------------------- 170

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1566407268 462 kVLKANPYTGGVKAFNATTGEQVWTRPQSTPATsglLATAGKLVFSGDAEGYFSALKDDTGEELWR 527
Cdd:pfam13360 171 -RVFASAYQGRLVAFDAATGRRLWTREISGPNG---PILDGDLLYVVSDDGELYALDRATGAVVWK 232
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 111-228 9.58e-09

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 57.52  E-value: 9.58e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 111 DSQTTVVNGRIYVTASQNKVFSLDGVTGKMLWKyeRSLPGdlgpklccdavNRGVAVYKDMVFMATLDTHVVALNNTTGQ 190
Cdd:COG1520   226 DGTPVVDGGVVYAVAYQGRLAALDLRSGRVLWS--RDLSS-----------YTGLAVDGNNLYVTDDDGRVWALDRRNGA 292

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1566407268 191 VVWE------RK------------MGDYQ---------TGEIY----------TSMPLVAKGMVIVGNSGGDVGA 228
Cdd:COG1520   293 ELWKqdallyRGltapvvlgdyvvVGDFEgylhwlsrdDGSLVarlrvdgsgiRAAPVVVGDTLYVQTRDGTLAA 367
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 471-563 1.11e-08

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 55.87  E-value: 1.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 471 GGVKAFNATTGEQVWTRPQSTPATSGLlATAGKLVFSGDAEGYFSALKDDTGEELWRFNVGSGIHGNPTtfTADGKQYVA 550
Cdd:pfam13360   3 GVVTALDAATGAELWRVDLETGLGGGV-AVDGGRLFVATGGGQLVALDAATGKLLWRQTLSGEVLGAPL--VAGGRVFVV 79

                          90
                  ....*....|...
gi 1566407268 551 ivygPGGGSLWPL 563
Cdd:pfam13360  80 ----AGDGSLIAL 88
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 111-241 2.10e-08

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 56.48  E-value: 2.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 111 DSQTTVVNGRIYVTASQNKVFSLDGVTGKMLWKYERSlpgdlgpklccdaVNRGVAVYKDMVFMATLDTHVVALNNTTGQ 190
Cdd:TIGR03300 234 DGDPVVDGGQVYAVSYQGRVAALDLRSGRVLWKRDAS-------------SYQGPAVDDNRLYVTDADGVVVALDRRSGS 300

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1566407268 191 VVWERKMGDYQtgeiYTSMPLVAKGMVIVGNsggdvgaNVGRITALDPATG 241
Cdd:TIGR03300 301 ELWKNDELKYR----QLTAPAVLGGYLVVGD-------FEGYLHWLDRDDG 340
BamB_YfgL cd10276
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ...
 469-549 6.07e-08

Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.


Pssm-ID: 199834 [Multi-domain]  Cd Length: 358  Bit Score: 55.03  E-value: 6.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 469 YTGGVKAFNATTGEQVWTRPQSTPA-TSGLLATAGKLVFSGDAEGYFSALKDDTGEELWRFNVGSGIHGNPTTFtADGKQ 547
Cdd:cd10276    46 ANGQVSAFNATTGKIIWETSLSGKGfLGGTPAVGNGKIFVGTESGYLYALDAKDGSELWRTEVSDSQLLSPPTY-ADGKI 124


                  ..
gi 1566407268 548 YV 549
Cdd:cd10276   125 YV 126
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 178-389 1.82e-07

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 52.41  E-value: 1.82e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 178 DTHVVALNNTTGQVVWERKMGDYQTGEiytsmPLVAKGMVIVGNSGgdvganvGRITALDPATGNTIW------EFKTRP 251
Cdd:pfam13360   2 DGVVTALDAATGAELWRVDLETGLGGG-----VAVDGGRLFVATGG-------GQLVALDAATGKLLWrqtlsgEVLGAP 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 252 TSADhpqAKTWANdswkTGGGSAWltgTYDAKTNTVLWGVGNPAP------DFDPSVRkGDNLYTNST----VALDADTG 321
Cdd:pfam13360  70 LVAG---GRVFVV----AGDGSLI---ALDAADGRRLWSYQRSGEplalrsSGSPAVV-GDTVVAGFSsgklVALDPATG 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 322 KIKyhfqytpndaWDY-----DGNNEMILVDDDKGRKVwLHGDR------NGHLYSIDRTNGKCNWVVPIARVN--WVTG 388
Cdd:pfam13360 139 KVR----------WEAplaapRGTNELERLVDITGTPV-VAGGRvfasayQGRLVAFDAATGRRLWTREISGPNgpILDG 207


                  .
gi 1566407268 389 F 389
Cdd:pfam13360 208 D 208
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 471-532 2.10e-06

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 50.20  E-value: 2.10e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1566407268 471 GGVKAFNATTGEQVWTRPQSTPATSGlLATAGKLVFSGDAEGYFSALKDDTGEELWRFNVGS 532
Cdd:COG1520    67 GRVAALDAATGKELWRVDLGEPLSGG-VGADGGLVVVGTEDGEVIALDADDGEELWRARLSS 127
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 107-245 2.94e-06

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 48.55  E-value: 2.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 107 NEAQDSQTTVVNGRIYVTASQNKVFSLDGVTGKMLWKYERSLPGDLGPKLCCDAVNRGVAVYKDMVFMATLDTHVVALNN 186
Cdd:pfam13360 107 ALRSSGSPAVVGDTVVAGFSSGKLVALDPATGKVRWEAPLAAPRGTNELERLVDITGTPVVAGGRVFASAYQGRLVAFDA 186

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1566407268 187 TTGQVVWERKMGDYQTgeiytsmPLVAKGMVIVGNSGgdvganvGRITALDPATGNTIW 245
Cdd:pfam13360 187 ATGRRLWTREISGPNG-------PILDGDLLYVVSDD-------GELYALDRATGAVVW 231
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 466-532 2.95e-06

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 49.55  E-value: 2.95e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1566407268 466 ANPYTGGVKAFNATTGEQVWTRPQSTPATSGLlATAGKLVFSGDAEGYFSALKDDTGEELWRFNVGS 532
Cdd:TIGR03300  70 AADADGTVAALDAETGKRLWRVDLDERLSGGV-GADGGLVFVGTEKGEVIALDAEDGKELWRAKLSS 135
PRK11138 PRK11138
outer membrane biogenesis protein BamB; Provisional
 461-531 7.21e-06

outer membrane biogenesis protein BamB; Provisional


Pssm-ID: 236857 [Multi-domain]  Cd Length: 394  Bit Score: 48.39  E-value: 7.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 461 SKVLKANPYtGGVKAFNATTGEQVWTR---------PQSTPAT-SGLLATAGKLVFSGDAEGYFSALKDDTGEELWRFNV 530
Cdd:PRK11138   70 NKVYAADRA-GLVKALDADTGKEIWSVdlsekdgwfSKNKSALlSGGVTVAGGKVYIGSEKGQVYALNAEDGEVAWQTKV 148


                  .
gi 1566407268 531 G 531
Cdd:PRK11138  149 A 149
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 471-533 1.10e-05

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 48.00  E-value: 1.10e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1566407268 471 GGVKAFNATTGEQVWTRPQSTPA----TSGLLATAGKLVFSGDAEGYFSALKDDTGEELWRFNVGSG 533
Cdd:TIGR03300 155 GRLTALDAATGERLWTYSRVTPPltlrGSASPVIADGGVLVGFAGGKLVALDLQTGQPLWEQRVALP 221
BamB_YfgL cd10276
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ...
 92-226 1.67e-05

Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.


Pssm-ID: 199834 [Multi-domain]  Cd Length: 358  Bit Score: 47.33  E-value: 1.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268  92 NVKKLVPKWNLSFGVNEAQ-------DSQTT--VVNGRIYVTASQNKVFSLDGVTGKMLWKYERSlpgdlgpklccdAVN 162
Cdd:cd10276   182 NTGTGVDIWEFSVSEPRGRtelprmiDSSVTyvVVGGYLYSTSYQGYLVALDFESGQFLWSRKAS------------GGT 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 163 RGVAVYKDMVFMATLDTHVVALNNTTGQVVWE------RK-------------MGDYQTGEIY----------------- 206
Cdd:cd10276   250 STSTDANGRVYVGDGEGSLYCLDASTGDELWSqtvllgRVlsspaiyvgvyiyVTDNAEGYLYclkdndgltvarvevdy 329

                         170       180
                  ....*....|....*....|....
gi 1566407268 207 ----TSMPLVAKGMVIVGNSGGDV 226
Cdd:cd10276   330 sqyiLQGPAVSDGWLYYGTDDGYL 353
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 471-532 1.52e-04

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 44.42  E-value: 1.52e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1566407268 471 GGVKAFNATTGEQVWTRPQSTPA----TSGLLATAGKLVFSGDAEGYFSALKDDTGEELWRFNVGS 532
Cdd:COG1520   147 GRVYALDAATGERLWSYQRPVPAltlrGTSSPVIVGGAVLVGFANGKLVALDLANGQPLWEQRVAQ 212
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 471-544 3.84e-03

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 39.31  E-value: 3.84e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1566407268 471 GGVKAFNATTGEQVWTRPQSTPA----TSGLLATAGKLVFSGDAEGYFSALKDDTGEELWRFNVGSGIHGNPTTFTAD 544
Cdd:pfam13360  83 GSLIALDAADGRRLWSYQRSGEPlalrSSGSPAVVGDTVVAGFSSGKLVALDPATGKVRWEAPLAAPRGTNELERLVD 160
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 471-557 9.06e-03

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 38.15  E-value: 9.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1566407268 471 GGVKAFNATTGEQVWtrpqSTPATSGLLAT---AGKLVFSGDAEGYFSALKDDTGEELWRF-NVGSGIHGNPTTFTADGK 546
Cdd:pfam13360  43 GQLVALDAATGKLLW----RQTLSGEVLGAplvAGGRVFVVAGDGSLIALDAADGRRLWSYqRSGEPLALRSSGSPAVVG 118

                          90
                  ....*....|.
gi 1566407268 547 QYVAIVYGPGG 557
Cdd:pfam13360 119 DTVVAGFSSGK 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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