|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
11-386 |
1.06e-52 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 179.73 E-value: 1.06e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 11 LKVLYSDTFIMAVGFYMLVPLLAYHFLQDLTLTIAAVAALTAVRTAAQNGMMPIAGWVADRINFRRAILIGVLVRASGFA 90
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 91 MLGTVDSVPLLVVASILTGLGGALFHPASYSAYAALTTGSDRIRVYSTREVVSNVGFIVGPIIGGFLAGADFAFVSLSAA 170
Cdd:cd17329 81 LLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 171 GMFVIAFIISAFGLP----GPGEDDKARTPPRLRVAFADLAFVRYCALVAGTAVLVAQFYLVIPFRAAEFTSGP-SDLGF 245
Cdd:cd17329 161 VLFLLAALVLLFLLPetrpKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGeSLLGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 246 IYSGAAIVMVLTMLPLTGAANRFlPDRVTLAGATTCLGVGVGIMGLSTNLFGMLVGVAVFIVGQMLAQPVLNATVSRFAP 325
Cdd:cd17329 241 LLALNALLIVLLQFPVARLVERF-RLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAP 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1563883176 326 EGSVASYFGVQGLANAIGGVVGSSSAGVIYALagsgePGASWVWLTYPAWAVIVAVLFVVF 386
Cdd:cd17329 320 PDKRGSYMGFYALAWGLGRAIGPLVGGLLLDL-----LGPGLPWLILAALGLIAAALLLGL 375
|
|
| PRK11646 |
PRK11646 |
multidrug efflux MFS transporter MdtH; |
17-370 |
4.15e-34 |
|
multidrug efflux MFS transporter MdtH;
Pssm-ID: 183255 Cd Length: 400 Bit Score: 130.95 E-value: 4.15e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 17 DTFIMAVGFYMLVPLLAYHFLQDLTLTIAAVAALTAVRTAAQNGMMPIAGWVADRINFRRAILIGVLVRASGFAMLGTVD 96
Cdd:PRK11646 18 DNMLVVLGFFVVFPLISIRFVDQLGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMAIAH 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 97 SVPLLVVASILTGLGGALFHPASYSAYAALTTGSDRIRVYSTREVVSNVGFIVGPIIGGFLAGADFAFVSLSAAGMFVIA 176
Cdd:PRK11646 98 EPWLLWLSCILSGLGGTLFDPPRTALVIKLIRPHQRGRFFSLLMMQDSAGAVIGALLGSWLLQYDFRLVCATGAVLFVLA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 177 FIISAFGLPgPGEDDKARTPPR--LRVAFADLAFVRYCALVAGTAVLVAQFYLVIPFRAAEFTSGPSDLGFIYSGAAIVM 254
Cdd:PRK11646 178 AAFNAWLLP-AYKLSTVRTPVRegMTRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPIMVNDIAGSPSAVKWMYAIEACLS 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 255 VLTMLPLTG-AANRFLPDRVTLAGATTcLGVGVGIMGLSTNLFGMLVGVAVFIVGQMLAQPVLNATVSRFAPEGSVASYF 333
Cdd:PRK11646 257 LTLLYPIARwSEKRFRLEHRLMAGLLI-MSLSMFPIGMVSNLQQLFTLICLFYIGSIIAEPARETLSASLADARARGSYM 335
|
330 340 350
....*....|....*....|....*....|....*...
gi 1563883176 334 GVQGLANAIGGVVGSSSAGVIYALAGS-GEPGASWVWL 370
Cdd:PRK11646 336 GFSRLGLALGGAIGYIGGGWLFDLGKAlNQPELPWMML 373
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
14-359 |
1.79e-29 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 117.68 E-value: 1.79e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 14 LYSDTFIMAVGFYMLVPLLAYhFLQDLTLTIAAVAALTAVRTAAQNGMMPIAGWVADRINFRRAILIGVLVRASGFAMLG 93
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPL-YAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 94 TVDSVPLLVVASILTGLGGALFHPASYSAYAALTTGSDRIRVYSTREVVSNVGFIVGPIIGGFLAGA-DFAFVSLSAAGM 172
Cdd:cd17325 80 FATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAlGYRAPFLVCAAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 173 FVIAFIISAFGLPGPGEDDKARTPP------RLRVAFADLAFVRYCALVAGTAVLVAQFYLVIPFRAAE-FTSGPSDLGF 245
Cdd:cd17325 160 ALLALVLALLLLPEPRPPPNKRAVSaarlrsGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAElGGLSPAQIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 246 IYSGAAIVMVLTMLPLTGAANRFLPDRVTLAGATTClGVGVGIMGLSTNLFGMLVGVAVFIVGQMLAQPVLNATVSRFAP 325
Cdd:cd17325 240 LFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLS-AVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVP 318
|
330 340 350
....*....|....*....|....*....|....
gi 1563883176 326 EGSVASYFGVQGLANAIGGVVGSSSAGVIYALAG 359
Cdd:cd17325 319 PEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG 352
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
9-344 |
4.46e-27 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 110.45 E-value: 4.46e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 9 FALKVLYSDTFIMAVGFYMLVPLLAYhFLQDLTLTIAAVAALTAVRTAAQNGMMPIAGWVADRINFRRAILIGVLVRASG 88
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPL-IAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 89 FAMLGTVDSVPLLVVASILTGLGGALFHPASYSAYAALTTGSDRIRVYSTREVVSNVGFIVGPIIGGFLAGA-DFAFVSL 167
Cdd:COG2814 89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLfGWRWVFL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 168 SAAGMFVIAFIISAFGLPGPGEDDKARTPPRLRVAFADLAFVRYCALVAGTAVLVAQFYLVIPFRAAE-FTSGPSDLGFI 246
Cdd:COG2814 169 VNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGLL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 247 YSGAAIVMVLTMLPLTGAANRFLPDRVTLAGAtTCLGVGVGIMGLSTNLFGMLVGVAVFIVGQMLAQPVLNATVSRFAPE 326
Cdd:COG2814 249 LALFGLGGVLGALLAGRLADRFGRRRLLLIGL-LLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPP 327
|
330
....*....|....*...
gi 1563883176 327 GSVASYFGVQGLANAIGG 344
Cdd:COG2814 328 EARGRASGLYNSAFFLGG 345
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
18-348 |
8.47e-21 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 92.48 E-value: 8.47e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 18 TFIMAVGFYMLVPLLAYHFLQDLTLTIAAVAALTAVRTAAQNGMMPIAGWVADRINFRRAILIGVLVRASGFAMLGTVDS 97
Cdd:pfam07690 5 AFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 98 VPLLVVASILTGLGGALFHPASYSAYAALTTGSDRIRVYSTREVVSNVGFIVGPIIGGFLAGA-DFAFVSLSAAGMFVIA 176
Cdd:pfam07690 85 LWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLfGWRAAFLILAILSLLA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 177 FIISAFGLPGPGEDDKARTPPRLRVAFADLAFVR------YCALVAGTAVLVAQFYLVIPFRAAEFTSGPSDLGFIYSGA 250
Cdd:pfam07690 165 AVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLrdpvlwLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 251 AIVMVLTMLPLTGAANRFLPDRVTLAGATTCLGVGVGIMGLSTNLFGMLVGVAVFIVG--QMLAQPVLNATVSRFAPEGS 328
Cdd:pfam07690 245 GLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGfgFGLVFPALNALVSDLAPKEE 324
|
330 340
....*....|....*....|
gi 1563883176 329 VASYFGVQGLANAIGGVVGS 348
Cdd:pfam07690 325 RGTASGLYNTAGSLGGALGP 344
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
11-360 |
1.36e-20 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 92.25 E-value: 1.36e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 11 LKVLYSDTFIMAVGFYMLVPLLAYhFLQDLTLTIAAVAALTAVRTAAQNGMMPIAGWVADRINFRRAILIGVLVRASGFA 90
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPA-IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 91 MLGTVDSVPLLVVASILTGLGGALFHPASYSAYAALTTGSDRIRVYSTREVVSNVGFIVGPIIGGFLAGADFAFVSLSAA 170
Cdd:cd17474 80 LCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 171 GMFVIAFIISAFGLPGPGEDDKARTPPRLRVAFADLAFVRYCALVAGTAVLVAQFYLVI---PFRAA-EFTSGPSDLGFI 246
Cdd:cd17474 160 ALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLtylPFLLElLYGISPIIIGLL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 247 YSGAAIVMVLTMLPLTGAANRFLPDRVTLAGATTCLGVGVGIMGLSTNLFGMLVGVAVFIVGQMLAQPVLNATVSRFAPE 326
Cdd:cd17474 240 FAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPE 319
|
330 340 350
....*....|....*....|....*....|....
gi 1563883176 327 GSVASYFGVQGLANAIGGVVGSSSAGVIYALAGS 360
Cdd:cd17474 320 EERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGL 353
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
19-374 |
1.11e-19 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 89.17 E-value: 1.11e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 19 FIMAVGFYMLVPLLAYHF--LQDLTLTIAAVAALTAVRTAAQNGMMPIAGWVADRINFRRAILIGVLVRASGFAMLGTVD 96
Cdd:cd17330 6 FLDALGFGIVFPVLPFYVreFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 97 SVPLLVVASILTGLGGALFhPASYSAYAALTTGSDRIRVYSTREVVSNVGFIVGPIIGGFLA-GADFAFVSLSAAGMFVI 175
Cdd:cd17330 86 NLWLLFLARFLDGLTGGNV-SVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLStPYGYALPFLVAAALALL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 176 AFIISAFGLPgpgeddkartppRLRvafadLAFVRYCALVAGTAVLVAQFYLvipFRAAEFTSGPSDLGFIYSGAAIVMV 255
Cdd:cd17330 165 NLVLVLFFLP------------PLR-----RLLLVYFLIALAFAGLESVFSL---FLKDRFGFSPSQIGLLLALVGIAGI 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 256 LTMLPLTGAANRFLPDRVTLAGATTCLGVGVGIMGLSTNLFGMLVGVAVFIVGQMLAQPVLNATVSRFAPEGSVASYFGV 335
Cdd:cd17330 225 LAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGI 304
|
330 340 350
....*....|....*....|....*....|....*....
gi 1563883176 336 QGLANAIGGVVGSSSAGVIYALAGSGEPGASWVWLTYPA 374
Cdd:cd17330 305 IQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIA 343
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
1-359 |
6.02e-19 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 88.04 E-value: 6.02e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 1 MAKRPPVSFALKVLYS-DTFIMAVGFYMLVPLLAYHFLQDLTLTIAAVAALTAVRTAAQNGMMPIAGWVADRIN-----F 74
Cdd:COG2211 1 TAAKKKLSLKEKLAYGlGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRtrwgrR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 75 RRAILIGVLVRASGFAMLGTVDSVP------LLVVASILTGLGGALFHPASYSAYAALTTGSD-RIRVYSTREVVSNVGF 147
Cdd:COG2211 81 RPWILIGAIPLALSFVLLFTAPDLSptgkliYALVTYLLLGLAYTLVNIPYSALGAELTPDYEeRTRLSSWRFAFAGLGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 148 IVGPIIGGFLAGA-------DFAFVSLSAAGMFVIAFIISAFGLPGPGEDDKARTPPR--LRVAFADLAFVRYCALVAGT 218
Cdd:COG2211 161 LLASVLPPPLVAAfggdaalGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKesLKALLKNRPFLLLLLAYLLF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 219 AVLVAQFYLVIPFRAAEFTSGPSDLGFIYSGAAIVMVLTMLPLTGAANRFLPDRVTLAGATTCLGVGVGIMGLS--TNLF 296
Cdd:COG2211 241 FLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgpGNLW 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 297 GMLVGVAVFIVGQMLAQPVLNATVSRFAPEGSVAS-------YFGVQGLANAIGGVVGSSSAGVIYALAG 359
Cdd:COG2211 321 LLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTgrrreglYFGIFTFAIKLGQALAGALAGLLLALFG 390
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
26-360 |
2.05e-16 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 80.16 E-value: 2.05e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 26 YMLVPLLAYHFLQDLTLTIAAVAALTAVRTAAQNGMMPIAGWVADRINFRRAILIGVLVRASGFAMLGTVDSVPLLVVAS 105
Cdd:cd06174 12 RGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 106 ILTGLGGALFHPASYSAYAALTTGSDRIRVYSTREVVSNVGFIVGPIIGGFLA---GADFAFVSLSAAGMFVIAFIISAF 182
Cdd:cd06174 92 FLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAsslGFGWRAVFLIAAALALLAAILLLL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 183 GLPGPGEDDKARTPPR--------LRVAFADLAFVRYCALVAGTAVLVAQFYLVIPFRAAE-FTSGPSDLGFIYSGAAIV 253
Cdd:cd06174 172 VVPDPPESARAKNEEAssksvlklLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDlGGLSVAVAGLLLSLFGLA 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 254 MVLTMLPLTGAANRFLPDRVTLAGATTCLGVGVGIMGLSTNLFGMLVGVAVFIVGQMLAQPVLNATVSRFAPEGSVASYF 333
Cdd:cd06174 252 GALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAF 331
|
330 340
....*....|....*....|....*..
gi 1563883176 334 GVQGLANAIGGVVGSSSAGVIYALAGS 360
Cdd:cd06174 332 GLLNTFGFLGGAIGPLLAGFLLAATFG 358
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
18-359 |
2.91e-16 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 79.56 E-value: 2.91e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 18 TFIMAVGFYMLVPLLAYhFLQDLTLTIAAVAALTAVRTAAQNGMMPIAGWVADRINFRRAILIGVLVRASGFAMLGTVDS 97
Cdd:cd17489 5 NFFFFLSFYLLLPVLPL-YAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 98 VPLLVVASILTGLGGALFHPASYSAYAALTTGSDRIRVYSTREVVSNVGFIVGPIIGGFLAGA-DFAFVSLSAAGMFVIA 176
Cdd:cd17489 84 VALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHlGFAVLFIVAAVLALLA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 177 FIIsAFGLPGPGEDDKARTPPRLRvafADLAFVRYCALVAGTAVLVAQ--FYLVIPFRAAEFTS-GPSDLGFIYSGAAIV 253
Cdd:cd17489 164 LLL-VFLVKDPPPVAAEEAEAGTR---AFRRLVEKKVLPPALILFLASiaYGAISTFLPLYAAErGISNAGLFFTVYAIA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 254 MVLTMLPLTGAANRFLPDRVTLAGATTcLGVGVGIMGLSTNLFGMLVGVAVFIVGQMLAQPVLNATVSRFAPEGSVASYF 333
Cdd:cd17489 240 LLLSRPFSGKLSDRKGPKTVIIPGLLL-LALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAAN 318
|
330 340
....*....|....*....|....*.
gi 1563883176 334 GVQGLANAIGGVVGSSSAGVIYALAG 359
Cdd:cd17489 319 GTFFIFFDLGIGLGGLLLGLVAELFG 344
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
36-359 |
4.73e-16 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 79.20 E-value: 4.73e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 36 FLQDLTLTIAAVAALTAVRTAAQNGMMPIAGWVADRINFRRAILIGVLVRASGFAML-----GTVDSVPLLVVASILTGL 110
Cdd:cd06173 25 LVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLallalLGSLSLWLLLVLAFLLGI 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 111 GGALFHPASYSAYAALTTGSDRIRVYSTREVVSNVGFIVGPIIGGFLAGA-DFAFVSLSAAGMFVIAFIISAFGLPGPGE 189
Cdd:cd06173 105 ASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALlGPGGAFAINALSFLLSALLLLFIRRPPPA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 190 DDKARTPPRLRVAFADLAFVRYCALVAGTAVLVAQFYLV--------IPFRAAEFTSGPSDLGFIYSGAAIVMVLTMLpL 261
Cdd:cd06173 185 APGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLggaltvllPLLAKEVLGGGAAGYGLLLAAFGVGALLGAL-L 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 262 TGAANRFLPDRVTLAGATTCLGVGVGIMGLSTNLFGMLVGVAVFIVGQMLAQPVLNATVSRFAPEGSVASYFGVQGLANA 341
Cdd:cd06173 264 LGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNS 343
|
330
....*....|....*...
gi 1563883176 342 IGGVVGSSSAGVIYALAG 359
Cdd:cd06173 344 GAMPLGALLAGLLADALG 361
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
19-391 |
6.47e-16 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 78.37 E-value: 6.47e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 19 FIMAVGFYMLVPLLAYHFLQDLTLTIAAVAALTAVRTAAQNGMMPIAGWVADRINFRRAILIGVLVRASGFAMLGTVDSV 98
Cdd:COG2271 19 YFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSF 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 99 PLLVVASILTGLGGALFHPASYSAYAALTTGSDRIRVYSTREVVSNVGFIVGPIIGGFLAGAdfafvsLSAAGMFVIAFI 178
Cdd:COG2271 99 WQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA------FGWRAAFLILGL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 179 ISAFGLPgpgeddkartpprlrVAFADLAFVRYCALVAGTAVLVaqfyLVIPFRAAEFTSGPSDLGFIYSGAAIVMVLTM 258
Cdd:COG2271 173 PGLLLAL---------------LRFWLLALAYFLVYFALYGFLT----WLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 259 LPLTGAANRFL-PDRVTLAGATTCLGVGVGIMGLSTNLFGMLVGVAVFIVGQMLAQPVLNATVSRFAPEGSVASYFGVQG 337
Cdd:COG2271 234 LLGGWLSDRLGrRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVN 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1563883176 338 LANAIGGVVGSSSAGVIYALAgsgepGASWVWLTYPAWAVIVAVLFVVFGPRRA 391
Cdd:COG2271 314 TFGFLGGALGPLLVGYLLDAT-----GYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
10-184 |
1.66e-15 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 77.23 E-value: 1.66e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 10 ALKVLYSDTFIMAVGFYMLVPLLAYHFLQDLTLTIAAVAALTAVRTAAQNGMMPIAGWVADRINFRRAILIGVLVRASGF 89
Cdd:cd17325 200 RLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVAL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 90 AMLGTVDSVPLLVVASILTGLGGALFHPASYSAYAALTTGSDRIRVYSTREVVSNVGFIVGPIIGGFLAGA-DFAFVSLS 168
Cdd:cd17325 280 LLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAfGFATPFLA 359
|
170
....*....|....*.
gi 1563883176 169 AAGMFVIAFIISAFGL 184
Cdd:cd17325 360 AAALLLLAAVLFLLLR 375
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
63-343 |
3.07e-15 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 76.46 E-value: 3.07e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 63 PIAGWVADRINFRRAILIGVLVRASGFAMLGTVDSVPLLVVASILTGLGGALFHPASYSAYAALTTGSDRIRVYSTREVV 142
Cdd:cd17473 53 PLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAA 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 143 SNVGFIVGPIIGGFLAGADFAFVSLSAAGMFVIAFIISAFgLPGPGEDDKARTPPRLRVAFADLAFVRYCALVAGTAVLV 222
Cdd:cd17473 133 MSLGGVVFLLLGGALAEIGWRAPFLVYLLALPVLILVLLF-LPEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAML 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 223 AqFYLV---IPFRAAEFTSG-PSDLGFIYSGAAIVMVLTMLpLTGAANRFLPDRVTLAGATTCLGVGVGIMGLSTNLFGM 298
Cdd:cd17473 212 L-FYVIpiqLPFLLQERGGGsAALIGLALAIASLAGAIGAL-LFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVV 289
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 1563883176 299 LVGVAVFIVGQMLAQPVLNATVSRFAPEGSVASYFGVQGLANAIG 343
Cdd:cd17473 290 LLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLG 334
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
14-363 |
1.36e-13 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 71.49 E-value: 1.36e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 14 LYSDTFIMAVGFYMLVPLLAYHfLQDLTLTIAAVAALTAVRTAAQNGMMPIAGWVADRINFRRAILIGVLVRASGFAMLG 93
Cdd:cd17390 1 LYLVGFLDLFGVSMILPLLSTH-IRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 94 TVDSVPLLVVASILTGLGGalfHPASYS-AYAA-LTTGSDRIRVYSTREVVSNVGFIVGPIIGGFLAGAD--FAFVSLSA 169
Cdd:cd17390 80 FSTSLALLFLSRIPLGIFK---HTQSLCkAYLSdLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDggFYYVALLC 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 170 AGMFVIAFIISAFGLPgpgeddkartpprlrvAFADLAFVRYCALVAGTaVLVAQFYLVIPFRaaeFTSGPSDLGFIYSG 249
Cdd:cd17390 157 SAIFILNAGLVWFLLS----------------KLWDLLLVRFLMGFSVL-LFRSNFSLYLEER---FDLSPKTIGYLISY 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 250 AAIVMVLTMLpLTGAANRFLP--DRVTLAGATTCLGVGVGIMGLSTNLFGMLVGVAVFIVGQMLAQPVLNATVSRFAPEG 327
Cdd:cd17390 217 SGVLGALSGF-LVGRILKLYKnnEYLLLLHSFILLALSLLGLALAPSIWLLVLCLTPLSISSAVLRTCSTSLLLSRGKSK 295
|
330 340 350
....*....|....*....|....*....|....*.
gi 1563883176 328 SVASYFGVQGLANAIGGVVGSSSAGVIYALAGSGEP 363
Cdd:cd17390 296 ERGTLLGVGQSVTSLARILAPLLSGLLQEFSVSGPG 331
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
11-368 |
9.81e-13 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 68.82 E-value: 9.81e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 11 LKVLYSDTFIMAVGFYMLVPLLAyHFLQDLTLTIAAVAALTAVRTAAQNGMM----PIAGWVADRINFRRAILIGVLVRA 86
Cdd:cd17388 1 LIFILVTVLLDAMGIGLIMPVLP-TLLREFVGDSADAATHYGVLLALYALMQfifaPILGALSDRFGRRPVLLLSLAGAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 87 SGFAMLGTVDSVPLLVVASILTGLGGALFhpASYSAYAA-LTTGSDRIRVYSTREVVSNVGFIVGPIIGGFLAGADFAFV 165
Cdd:cd17388 80 LDYLLMAFAPTLWWLYLGRIIAGITGATG--AVAAAYIAdVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISPRAP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 166 SLSAAGMFVIAFIISAFGLPG--PGEDDKARTPPRLRvAFADLAFVRYCALVAGTAVLVAQFYLV--IP------FRAAE 235
Cdd:cd17388 158 FLVAAGLNGLNFLLGLFVLPEslPPERRRAFRWRRAN-PFGSLRWLTGFPGLLGLLAVFFLIQLIgqVPattwvlFTEDR 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 236 FTSGPSDLGFIYSGAAIVMVLTMLPLTGAANRFLPDRVTLAGATTCLGVGVGIMGLSTNLFGMLVGVAVFIVGQMlAQPV 315
Cdd:cd17388 237 FDWSPTMVGLSLAVFGLLHALFQAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALGGI-AGPA 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1563883176 316 LNATVSRFAPEGSVASYFGVQGLANAIGGVVGSSSAGVIYALAGSGEPGASWV 368
Cdd:cd17388 316 LQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAASPATWPGLAWI 368
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
27-182 |
2.27e-12 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 67.58 E-value: 2.27e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 27 MLVPLLAYhFLQDLTLTIAAVAALTAVRTAAQNGMMPIAGWVADRINFRRAILIGVLVRASGFAMLGTVDSVPLLVVASI 106
Cdd:cd17478 14 FLPALLPL-LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVA 92
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1563883176 107 LTGLGGALFHPASySAYAALTTGSDRIRVYSTREVVSNVGFIVGPIIGGFLAGADFAFVSLSaagMFVIAFIISAF 182
Cdd:cd17478 93 LAGIGSAAFHPEG-ARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLI---LLIIPGLAVAL 164
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
19-395 |
2.78e-12 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 67.60 E-value: 2.78e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 19 FIMAVGFYMLVPLLAYHFLQDLTLTIAAVAALTAVRTAAQNGMMPIAGWVADRINFRRAILIGVLVRASGFAMLGTVDSV 98
Cdd:COG2223 14 FFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSY 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 99 PLLVVASILTGLGGALFHPASYSAYAALTTGSDRIRVYSTREVVSNVGFIVGPIIGGFLAGA-DFAFVSLSAAGMFVIAF 177
Cdd:COG2223 94 WLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAfGWRNAFLILGILLLVVA 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 178 IISAFGLPGPGEDDKARTPPRLR---VAFADLAFVRYCALVAGT--AVLVAQFYLViPFRAAEFTSGPSDLGFIYSGAAI 252
Cdd:COG2223 174 VLAWLFLRDPPAGAAAAAKASLRdqlEALRDPRFWLLSLLYFGTfgSFIGFSSWLP-PYLVDQFGLSAATAGLLAALFAL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 253 VMVLTMLPLTGAANRFLPDRVTLAGATTCLGVGVGIMGLSTNLFGMLVGVAVFIVGQMLAQPVLNATVSRFAPEGSVASY 332
Cdd:COG2223 253 LGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAV 332
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1563883176 333 FGVQGLANAIGGVVGSSSAGVIYALAGSgepgASWVWLTYPAWAVIVAVLFVVFGPRRASGSA 395
Cdd:COG2223 333 YGLVGAAGGLGGFLGPLLFGALLDATGS----YTAAFLVFAVLALVALVLTLLLYRRPRRAAA 391
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
66-359 |
4.73e-12 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 66.86 E-value: 4.73e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 66 GWVADRINFRRAILIGVLVRASGFAMLGTVDSVPLLVVASILTGLGGalFHPASYSAYAALTTGSDRIRVYSTREVVSN- 144
Cdd:cd17472 53 GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGA--ISSVVMALLADLTREENRTKAMALIGASIGi 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 145 ---VGFIVGPIIGGFLaGADFAFVSLSAAGMFVIAFIISAFGLPGPGEDDKARTPPRLRVAFADLAFVRYCALV-AGTAV 220
Cdd:cd17472 131 afaISMVLGPLLAAHL-GVSGLFLITAILSLVSLLILLFFVPDPPKIVQISEKEKKKLKKLLKNKRLLRLDFSIfILHFV 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 221 LVAQFYlVIPFRAAEFTSGPSDLGFIYSGAAIVMVLTMLPLTGAANRFLPDRVTLAGATTCLGVGVGIMGL-STNLFGML 299
Cdd:cd17472 210 LMAFFY-ILPLLLTQLGGGKGQLWKVYLPAILIGFILMVPFVIYAEKKGKMKQVFVSSILLIAVGFLLLLFaATSLWLLI 288
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 300 VGVAVFIVGQMLAQPVLNATVSRFAPEGSVASYFGVQGLANAIGGVVGSSSAGVIYALAG 359
Cdd:cd17472 289 IGLIIFFIGFNLLEALLPSLVSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLG 348
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
27-355 |
4.24e-11 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 63.72 E-value: 4.24e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 27 MLVPLLAYhFLQDLTLTIAAVAALTAVRTAAQNGMMPIAGWVADRINFRRAI-LIGVLVRASGFAMLGTVDSVPLLVVAS 105
Cdd:cd17370 17 MARSILPL-FLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLvILGYGLSALAKPLLALAGSWQLVLLLR 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 106 ILTGLGGALFHPASYSAYAALTTGSDRIRVYSTREVVSNVGFIVGPIIGGFLagadFAFVSLSAAGMFVIAFIISAFGL- 184
Cdd:cd17370 96 ILERLGKGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALL----LYLLGGNYRTIFLLAAIPALLALl 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 185 -------PGPGEDDKARTPPRLRVAFADLAFVRYCALVAgtavLVAQFYLVIPF---RAAEFTSGPSDLGFIYSGAAIVM 254
Cdd:cd17370 172 illfvvkEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVA----LFALGNFSFAFlilRAQELGLSAALIPLLYALFNLVY 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 255 VLTMLPLTGAANRFLPDRVTLAGATtCLGVGVGIMGLSTNLFGMLVGVAVFIVGQMLAQPVLNATVSRFAPEGSVASYFG 334
Cdd:cd17370 248 ALAAYPAGRLSDRIGRKKLLILGYL-SLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYG 326
|
330 340
....*....|....*....|.
gi 1563883176 335 VQGLANAIGGVVGSSSAGVIY 355
Cdd:cd17370 327 LFNTVVGIGWLLASLIAGYLW 347
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
24-389 |
9.99e-11 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 62.98 E-value: 9.99e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 24 GFYMLVPLLAYHFLQDLTLTIAAVAALTAVRT-AAQNGMMPIA-GWVADRI-NFRRAILIGVLVRASGFAMLGTVD-SVP 99
Cdd:cd17346 17 SYYGMRAILILYLTAQLGDGFSEADAASIYGAyTALVYLTPIIgGWLADKVlGARRTVFIGGILMALGYLLLALSPfSVS 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 100 LLVVASILTGLGGALFHPASYSAYAALTTGSD--RIRVYSTREVVSNVGFIVGPIIGGFLAGA-DFAFVSLSAAGMFVIA 176
Cdd:cd17346 97 MLYLGLALIIVGNGLFKPNISSLVGKLYDENDprRDSGFSIFYMGINLGAFLAPLLCGTLGDNyGYHYGFGLAAVGMLLG 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 177 FIISAFGlpgpgeddKARTPPRLRVafadLAFVRYCALVAGTAVLVAQFYLVIPFRAAEFTSGpSDLGFIYSGAAI---- 252
Cdd:cd17346 177 LLIFLLG--------RKKLLERKKM----LAIIILFLFAVVFWAIYEQAGTSLALFADENVDR-LLGGFTIPPSWFqsln 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 253 ---VMVLTML-----PLTGAANRFLPDRVTLAGATTCLGVGVGIMGLSTNLFG---------MLVGVAVFIVGQMLAQPV 315
Cdd:cd17346 244 plfIILLAPIlaalwTKLGKRGKDPSIPTKFALGLLLLGLSFLLMVLAASFAGgsgkvsalwLVLSYFLQTLGELCLSPV 323
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1563883176 316 LNATVSRFAPEGSVASYFGV----QGLANAIGGVVGSSSAGVIYALAGSGEPGAswVWLTYPAWAVIVAVLFVVFGPR 389
Cdd:cd17346 324 GLSMITKLAPAKFAGFMMGLwflaSALGNILAGYLAGFYAQPKDPLASALVYTD--YFGLIGVIALVAGIILLLLAKK 399
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
18-380 |
1.10e-10 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 62.57 E-value: 1.10e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 18 TFIMAVGFYMLVPLLAyHFLQDLTLTIAAVAALTAVRTAAQNGMMPIAGWVADRINFRRAILIGVLVRASGFAMLGTVDS 97
Cdd:cd17324 8 AFAIGTTEYVIQGLLP-DIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 98 VPLLVVASILTGLGGALFHPASYSAYAALTTGSDRIRVYSTREVVSNVGFIVGPIIGGFLAGA-DFAFVSLSAAGMFVIA 176
Cdd:cd17324 87 FALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLlGWRAAFLAIAVLALLA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 177 FIISAFGLPgPGEDDKARTPPRLRVAFADLAFVRYCALVAGTAVLVAQFYLVI----PFRAAEFTSGPSDLGFIYSGAAI 252
Cdd:cd17324 167 ALLLWRLLP-SLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYtylaPFLTDVPGFSSSAIIGLLLLFGV 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 253 VMVLTMlPLTGAANRFLPDRVTLAGATTCLGVGVGIMGLSTNLFGMLVGVAVFIVGQMLAQPVLNATVSRFAPEGS---V 329
Cdd:cd17324 246 AGVVGS-PLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARglaS 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1563883176 330 ASYFGVQGLANAIGGVVGSssagviYALAGSGEPGASWVWLTYPAWAVIVA 380
Cdd:cd17324 325 SLYLAAYNLGGALGAALGG------LVLDHGGWAGVGWVGAALLLLALLLA 369
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
19-359 |
1.24e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 62.56 E-value: 1.24e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 19 FIMAVGFYMLVPLLAyHFLQDLTLTIAAVAALTAVRTAAQNGMMPIAGWVADRINFRRAILIGVLVRASGFAMLGTVDSV 98
Cdd:COG0738 18 FLWGFATALWGPLIP-ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSY 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 99 PLLVVASILTGLGGALFHPASYsAYAALTTGSDRIRVYSTREVVSNVGFIVGPIIGGFLAGADFAF-----VSLSAAGMF 173
Cdd:COG0738 97 PLLLLALFLLGLGLGLLDVAAN-PYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLswhlpYLILAVLLL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 174 VIAFIISAFGLPGPGEDDKARTPPR--LRVAFADLAFVRYC-ALVAGTAVLVAQFYLVIPFRAAEFTSGPSDLGFIYSGA 250
Cdd:COG0738 176 LLALLFLRSKLPEIEEEEEEAAGSAasLKSLLKNPRLLLGGlAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLF 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 251 AIVMVLTMLpLTGAANRFLPDRVTLAGATTCLGVGVGIMGLSTNLFGMLVGVAVFIVGQMLAQPVLNATVSRFAPEGSvA 330
Cdd:COG0738 256 WGGMTIGRF-LGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRT-A 333
|
330 340
....*....|....*....|....*....
gi 1563883176 331 SYFGVQGLANAIGGVVGSSSAGVIYALAG 359
Cdd:COG0738 334 AAVSAVLIMGIVGGAIGPPLIGFLADAFG 362
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
14-386 |
9.21e-10 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 59.88 E-value: 9.21e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 14 LYSDTFIMAVGFYMLVPLLAYHFLQD--LTLTIAAVAALTAVRTAAqngMMPIAGWVADRINFRRAILIGVLVRASGFAM 91
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLEREgvSTALIGLVASAYYLGILL---GSPLVPRLIRRVGHIRAFAAGAAITAVSVLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 92 LGTVDSVPLLVVASILTGLGGALFHPASYSAYAALTTGSDRIRVYSTREVVSNVGFIVGPIIGGFLAGADFAFVSLSAAG 171
Cdd:cd17477 78 LALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPFLIAAVL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 172 MFVIAFIISAFGLPGPGEDDKARTPPRLRVAFADLAFVryCALVAGtaVLVAQFYLVIPFRAAEFTSGPSDLGFIYSGAA 251
Cdd:cd17477 158 LLLALVPLLLTRRAAPEIEEAESISLRRLLRIAPLALL--GAFVAG--FLEGAFYSLLPLYGLRLGLSVAQAALLLAAFV 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 252 IVMVLTMLPLTGAANRFLPDRVTLAGATTCLGVGVGIMGLSTNLFGMLVGVAVFIVGQMLAQPVLNATVSRFAPEGSVAS 331
Cdd:cd17477 234 LGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVA 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1563883176 332 YFGVQGLANAIGGVVGSSSAGVIYALAGSgepgaswvwLTYPAWAVIVAVLFVVF 386
Cdd:cd17477 314 ANAALLLLYGLGSVIGPLLAGALMDAFGP---------HGLFLFLAAVALLFLLF 359
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
60-380 |
8.85e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 56.80 E-value: 8.85e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 60 GMMPIAGWVADRINFRRAILIGVLVRASGFAMLGTVDSVPLLVVASILTGLGGALFHPASYSAYAALTTGSDRIRVYSTR 139
Cdd:cd17321 46 ALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLW 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 140 EVVSNVGFIVGPIIGGFLAGAdfafvsLSAAGMFVIAFIISAFGLPGpgeddkarTPPRLRVAFADLAFvryCALVAGTA 219
Cdd:cd17321 126 GAVVGIGAALGPLLGGLLLEL------FGWRWIFLINVPIGLVALLL--------ARTFSGAVLAAFLL---GAALGGLL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 220 VLVAQFYLVIpfraaeFTSGPSDLGFIYSGAAIVMVLtMLPLTGAANRFLPDRVTLAGATTCLGVGVGIM---GLSTNLF 296
Cdd:cd17321 189 FLLPLYLQGV------LGYSPLQAGLALLPLALAMLV-AAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLallGADSSVW 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 297 GMLVGVAVFIVGQMLAQPVLNATVSRFAPEGSVASYFGVQGLANAIGGVVGSSSAGVIYALAGSGEPGASWVWLTYPAWA 376
Cdd:cd17321 262 LLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAGLSANLGDSGVAALLSAAA 341
|
....
gi 1563883176 377 VIVA 380
Cdd:cd17321 342 AAFA 345
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
63-359 |
3.88e-08 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 54.92 E-value: 3.88e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 63 PIAGWVADRINFRRAILIGVLVRASGFAMLGTVDSVPLLvvasILTGLGGALFH--PASYSAYAALTTGSDRIRVYSTRE 140
Cdd:cd17331 53 PLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPML----FLSRLPSVFMHamQAAQMVVTDLTDPGERAAALGRLG 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 141 VVSNVGFIVGPIIGGFLAGA--DFAFVSLSAAGMFVIAFIISAFgLPGP--GEDDKARTPPRLRVAFADLAFVRYCALVA 216
Cdd:cd17331 129 LSYGIGMVVGSFLGGLLTKKfgEQAAALVAAVGSLLSIVLVILL-IPSNtkSKREKEAKESASPPSVFNLKEILRLLRLP 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 217 GTA-VLVAQFYLVIP---FRAA-------EFTSGPSDLGFIYSGAAIVMVLTMLPLTGAANRFLPDRVTLAGATTCLGVG 285
Cdd:cd17331 208 GVAfLLLVKLLSGLPigmFQSMfslvamdFFGLTPEENGYLMSYAGVLGMVVQGLLVGPLTKRFGERSLLKLSVALLAIG 287
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1563883176 286 VGIMGLSTNLFGMLVGVAVFIVGQMLAQPVLNATVSRFAPEGSVASYFGVQGLANAIGGVVGSSSAGVIYALAG 359
Cdd:cd17331 288 YLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYG 361
|
|
| PTR2 |
COG3104 |
Dipeptide/tripeptide permease [Amino acid transport and metabolism]; |
61-389 |
9.81e-08 |
|
Dipeptide/tripeptide permease [Amino acid transport and metabolism];
Pssm-ID: 442338 [Multi-domain] Cd Length: 479 Bit Score: 53.66 E-value: 9.81e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 61 MMPIAG-WVADR-INFRRAILIGVLVRASGFAMLGTVDSVPLLVVASILTGLGGALFHPASYSAYAALTTGSDRIR--VY 136
Cdd:COG3104 70 LTPLLGgWLADRlLGQRRAILLGGILMALGHFLLALPGGVTLFYLGLALIAVGNGLFKPNISSLVGQLYDPGDPRRdaGF 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 137 STREVVSNVGFIVGPIIGGFLA---GADFAFvSLSAAGMFvIAFIISAFG---LPGPGEDDKARTPPRLRVAFADLAFVR 210
Cdd:COG3104 150 TIFYMGINIGAFLAPLLCGYLGekyGWHYGF-GAAAIGML-IGLIIFLLGrkyLGDIGLEPDNPLSKKERLIAVALGALL 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 211 YCALVAG-----------TAVLVAQFYLVIPFRAAEFTSGPSD---LGFIYSGAAIV----------------------- 253
Cdd:COG3104 228 LVLVLAGllsnanianylLYVIAIIAYFIFILRSKKLTKEERKrllAILILFLFSIVfwalyeqagtslnlfadrnvdrs 307
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 254 -----------------MVLTMLPLTGAANRFLPDR-------VTLAGATTCLGVGVGIMGLSTNLFG---------MLV 300
Cdd:COG3104 308 lfgfeippswfqslnplFIIILAPVFAALWTKLGKRgkepstpTKFALGLLLLGLGFLVMALAALLAGaggkvsplwLVL 387
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 301 GVAVFIVGQMLAQPVLNATVSRFAPEGSVASYFGVQGLANAIGGVVgsssAGVIYALAgsGEPGASWVWLTYPAWAVIVA 380
Cdd:COG3104 388 AYLLLTIGELCLSPVGLSMITKLAPARFAGQMMGLWFLATALGNLL----AGLLAGLY--AVPGYTAYFLLLGGIALVAG 461
|
....*....
gi 1563883176 381 VLFVVFGPR 389
Cdd:COG3104 462 VVLLLLSPK 470
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
38-364 |
3.86e-07 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 51.42 E-value: 3.86e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 38 QDLTLTIAAVAALTAVRTAAQNGMMPIAGWVADRINFRRAILIGVLVRASGFAMLGTVDSVPLLVVASILTGLGGALFHP 117
Cdd:cd17319 31 KDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFP 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 118 ASYSAYAALTTGSDRIRVYSTREVVSNVGFIVGPIIGGFLAGAdfafvsLSAAGMFVIafiisaFGLPGpgeddkartpp 197
Cdd:cd17319 111 GAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLL------FGWRWAFII------EGLLG----------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 198 rLRVAFADLAFVR---YCALVAGTAVLVAQFYL--VIPFRAAEFTSGPSDLGFIYSGAAIVMVLTMLPLTGAANRFLPD- 271
Cdd:cd17319 168 -LLLAVLWWFYLRqvwGLALGYFGINYALYGLLtwLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGa 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 272 -RVTLAGATTCLGVGVGIMGLSTNLFGMLVGVAVFIVGQMLAQPVLNATVSRFAPEGSVASYFGVQGLANAIGGVVGSSS 350
Cdd:cd17319 247 rRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLL 326
|
330
....*....|....
gi 1563883176 351 AGVIYALAGSGEPG 364
Cdd:cd17319 327 IGYLVDATGSYTAA 340
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
14-300 |
4.65e-07 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 51.39 E-value: 4.65e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 14 LYSDTFIMAVGFYMLVPLLAYHFLQDLTLTIAAVAALTAVRTAAQNGMMPIAGWVADRINFRRA-ILIGVLVRASGFAML 92
Cdd:cd17471 1 LLLATLLTGLAGAFVLPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRKPlILLALLAGALGYLLF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 93 GTVDS-VPLLVVASILTGLGGALFhPASYS---AYAALTTGSDRIRVYSTREVVSNVGFIVGPIIGGFLAGA-DFAFVSL 167
Cdd:cd17471 81 AFLRNyWVLLLVGVVLLSLGAAAF-PQLFAlarEYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVlGFTGLFL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 168 SAAGMFVIAFIISAFGLPGPGEDDKARTPPRLRVAFADLAFVRYCALVAGTAVLVAQFYLV-IP-FRAAEFTSGPSDLGF 245
Cdd:cd17471 160 LAALLYLVVALLVLFLLPSVKPPAQKATPASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIaMPlYVTNELGGSESWVGL 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 1563883176 246 IYSGAAIVMVLTMLPLTGAANRFLPDRVTLAGATTCLgVGVGIMGLSTNLFGMLV 300
Cdd:cd17471 240 LFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGV-LFYLGLALATSLWQLIA 293
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
38-357 |
5.82e-07 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 51.04 E-value: 5.82e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 38 QDLTLTIAAVAALTAVRTAAQNGMMPIAGWVADRINFRRAILIGVLVRASGFAMLGTVDSVPLLVVASILTGLGGALFHP 117
Cdd:cd17320 27 RDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSV 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 118 ASYSAYAALTTGSDRIRVYSTREVVSNVGFIVGPIIGGFLAG-----ADFAFVslsaAGMFVIAFIISAFGLPGPGEDDK 192
Cdd:cd17320 107 VARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLffgwrAIFVFL----ALLGLLLLLLVLLFLPETLPEEK 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 193 ARTPPR-----LRVAFADLAFVRYCALVAGTAVLVAQFYLVIPFRAAE-FTSGPSDLGFIYSGAAIVMVLTMLPLTGAAN 266
Cdd:cd17320 183 RKPLLSsllraYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEqLGLSPAQFGLLFALNAIALILGSLLNGRLVR 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 267 RFLPDRVTLAGATTCLGVGVGIMGLST----NLFGMLVGVAVFIVGQMLAQPVLNATVSRFAPE--GSVAS-----YFGV 335
Cdd:cd17320 263 RFGPRRLLRLGLLLLLAAALVLLLAALlgglSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHvaGTASAllgflQFLI 342
|
330 340
....*....|....*....|..
gi 1563883176 336 QGLANAIGGVVGSSSAGVIYAL 357
Cdd:cd17320 343 GALAGALVGLLPNGTALPMGLL 364
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
18-297 |
1.26e-06 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 49.81 E-value: 1.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 18 TFIMAVGFYMLVPLLAYhFLQDLTLTIAAVAALTAVRTAAQNGMMPIAGWVADRINFRRAILIGVLVRASGFAMLGTVDS 97
Cdd:COG0477 23 TFLEGLDFTIVNVALPS-IAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPS 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 98 VPLLVVASILTGLGGALFHPASYSAYAALTTGSDRIRVYSTREVVSNVGFIVGPIIGGFLAGAdfafvsLSAAGMFVIAF 177
Cdd:COG0477 102 PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAA------LGWRWIFLINA 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 178 IISAFGLPGPGEDDKARTPPRLRVAFADLAFVRYCALVAGTAVLVAQFYLVIPFRAAEFTSGPSDLGFIYSGAAIVMVLT 257
Cdd:COG0477 176 PLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLA 255
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 1563883176 258 MLPLTGAANRFLPDRVTLAGATTCLGVGVGIMGLSTNLFG 297
Cdd:COG0477 256 LLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| PRK10054 |
PRK10054 |
efflux MFS transporter YdeE; |
66-338 |
1.66e-06 |
|
efflux MFS transporter YdeE;
Pssm-ID: 182213 Cd Length: 395 Bit Score: 49.74 E-value: 1.66e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 66 GWVADRINFRRAILIGVLVRASGFAMLGTVDSVPLLVVASILTGLGGALFHPASYSAYAALTTGSDRIRVYSTREVVSNV 145
Cdd:PRK10054 64 GILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVVLFFALINCAYSVFSTVLKAWFADNLSSTSKTKIFSLNYTMLNI 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 146 GFIVGPIIGGFLA--GADFAF---VSLSAAGMFVIAFIISAFGLPGPGEDDKARTPPRLRVAFADLAFVR---YCALVAG 217
Cdd:PRK10054 144 GWTVGPPLGTLLVmqSINLPFwlaAICSAFPLVFIQIWVQRSEKAIATETGSVWSPSVLLQDKALLWFTCsgfLASFVSG 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 218 T-AVLVAQFYLVIpfraaeftsgpSDLGFIYSGAAIV------MVLTMLPLTGAANRFLPDRVTLAGATTCLGVG-VGIM 289
Cdd:PRK10054 224 AfASCISQYVMVV-----------ADSDFAEKVVAVVlpvnaaMVVSLQYSVGRRLNAANIRPLMTAGTLCFVIGlVGFI 292
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 1563883176 290 GLSTNLFGMLVGVAVFIVGQMLAQPVLNATVSRFAPEGSVASYFGVQGL 338
Cdd:PRK10054 293 FSGNSLLLWGMSAAVFTVGEIIYAPGEYMLIDHIAPPGMKASYFSAQSL 341
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
63-182 |
1.93e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 49.51 E-value: 1.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 63 PIAGWVADRINFRRAILIGVLVRASGFAMLGTVDSVPLLVVASILTGLGGALFHPASYSAYAALTTGSDRIRVYSTREVV 142
Cdd:cd17489 245 PFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIF 324
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1563883176 143 SNVGFIVGPIIGGFLA-GADFAFVSLSAAGMFVIAFIISAF 182
Cdd:cd17489 325 FDLGIGLGGLLLGLVAeLFGYRAMFLLAAVVVLLALVLYIF 365
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
18-386 |
3.04e-06 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 48.81 E-value: 3.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 18 TFIMAVGFYMLVPLLAYHflQDLTLTIAAVAALTAVRTAAQNGMMPIAGWVADRINFRRAILIGVLVRASGFAMLGTVDS 97
Cdd:cd17355 13 ILSWGIRYYFGVFIIPII--AEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATS 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 98 VPLLVVASILTGLGGALFhpASYSAYAALTTGSDRIRVYSTREVVSNVG----FIVGPIIGGFLAGADFAFVSLSAAGMF 173
Cdd:cd17355 91 LWQLYLLWGLLGGGGAGT--LAAVAFATVAAWWFERRRGLALGILTAGGglgsLVFLPLGAALIEAFGWRTALLVLALLA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 174 VIAFIISAFGLPGPGEDDKARTPPR---------LRVAFADLAFVRYCALVAGTAVLVAQFYLVIPFRAAEFTSGPSDLG 244
Cdd:cd17355 169 LLVLVPVLLLLRRRPADLALRAYDDaspaspgstLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 245 FIYSGAAIVMVLTMLPLTGAANRFLPdRVTLAGATTCLGVGVGIMGLSTNLFGMLVGVAVFIVGQMLAQ-PVLNATVSRF 323
Cdd:cd17355 249 VALALIGLFNIVGRLLSGWLGDRYSP-RRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATvPLTAALAARY 327
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1563883176 324 APEGSVASYFGVQGLANAIGGVVGSSSAGVIYALAGSGepgaSWVWLTYPAWAVIVAVLFVVF 386
Cdd:cd17355 328 FGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSY----TAAWALAVALGLIAALLVLPI 386
|
|
| 2A0121 |
TIGR00900 |
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds] |
63-337 |
1.28e-05 |
|
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 162098 [Multi-domain] Cd Length: 365 Bit Score: 46.93 E-value: 1.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 63 PIAGWVADRINFRRAILIGVLVRA------SGFAMLGTVdSVPLLVVASILTGLGGALFHPASYSAYAALTTGSDRIRVY 136
Cdd:TIGR00900 52 PIAGALADRYDRKKVMIGADLIRAvlvavlPFVALLGGL-NIWQVYVLAGILAIAQAFFTPAYQAMLPDLVPEEQLTQAN 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 137 STREVVSNVGFIVGPIIGGFLAGadfaFVSLSAA-GMFVIAFIISA---FGLPGPGEDDKARTPPR---LRVAFADLAFV 209
Cdd:TIGR00900 131 SLSQAVRSLFYIVGPGIGGLMYA----TLGIKWAiWVDAVGFAISAlliVSVRIPELAASEIQALSnavLRDTREGIKFV 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 210 RYCALVAGTAVLVAQFYLV--------IPFRAAEFTSGPS-DLGFIYSGAAIVMVLTMLpLTGAANRFLPDRVTLAGATT 280
Cdd:TIGR00900 207 LKNPLLRTLLLLALLFNLVfapaivalFPYVQSKYLGRGStHYGWVLAAFGLGALLGAL-LLGLLGRYFKRMALMTGAIF 285
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1563883176 281 CLGVGVGIMGL-STNLFGMLVGVAVFIVGQMLAQPVLNATVSRFAPEGSVASYFGVQG 337
Cdd:TIGR00900 286 VIGLAILVVGLtPPNFPLFLVLWFAIGVGYGPINVPQGTLLQRRVPAELLGRVFGAQF 343
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
18-184 |
1.59e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 46.82 E-value: 1.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 18 TFIMAVGFYMLVPLLAYHFLQDLTLTIAAVAALTAVRTAAQNGMMPIAGWVADRINFRRAILIGVLVRASGFAMLGTV-- 95
Cdd:COG2211 237 YLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgp 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 96 DSVPLLVVASILTGLGGALFHPASYS------AYAALTTGSDRI-RVYSTREVVSNVGFIVGPIIGGFLAGAdFAFVSLS 168
Cdd:COG2211 317 GNLWLLLVLAALAGIGLGAILVLPWAmladvvDYDEWKTGRRREgLYFGIFTFAIKLGQALAGALAGLLLAL-FGYVAGA 395
|
170
....*....|....*.
gi 1563883176 169 AAGMFVIAFIISAFGL 184
Cdd:COG2211 396 AQSPSALTGIRLLFFL 411
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
38-387 |
2.15e-05 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 46.40 E-value: 2.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 38 QDLTLTIAAVAALTAVRTAAQNGMMPIAGWVADRINFRRAILIGVLVRASGFAMLGTVDSVPLLVVASILTGLGGALFHP 117
Cdd:COG2807 46 ADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNV 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 118 A-------SYSAYAALTTGsdrirVYSTrevVSNVGFIVGPIIGGFLAGAD---FAFVSLSAAgMFVIAFIISAFGLPGP 187
Cdd:COG2807 126 LlpglikrWFPDRVGLMTG-----LYTA---AMGLGAALAAGLTVPLAAALgwrGALAVWALL-ALLALLLWLPLLRRRP 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 188 GEDDKARTPPRLRVAFADLAFVrycALVAGTAVLVAQFYLVIPFRAAEFTS---GPSDLGFIYSGAAIVMVLTMLPLTGA 264
Cdd:COG2807 197 AAAAAAPAAASLRSLWRSPLAW---LLTLFFGLQSLLYYAVVAWLPPILRDaglSAATAGLLLSLFQLAGIPGSLLVPLL 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 265 ANRFLPDRVTLAGATTCLGVGVGIMGLSTNLFGMLVGVAVFIVGQMLAQPVLNATVSRFAPEGSVASYFGVQGLANAIGG 344
Cdd:COG2807 274 ADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAALSGMAQSVGYLLA 353
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1563883176 345 VVGSSSAGVIYALAGSgepgASWVWLTYPAWAVIVAVLFVVFG 387
Cdd:COG2807 354 ALGPLLVGALHDATGS----WTAALLLLAALAVLMLVAGLLAG 392
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
62-158 |
3.61e-05 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 45.25 E-value: 3.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 62 MPIAGWVADRINFRRAILIGVLVRASGFAMLGTVDSVPLLVVASILTGLGGALFHPASYSAYAALTTGSDRIRVYSTREV 141
Cdd:cd17502 47 QPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGA 126
|
90
....*....|....*..
gi 1563883176 142 VSNVGFIVGPIIGGFLA 158
Cdd:cd17502 127 VFGIASVAGPLIGGAFT 143
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
18-182 |
4.61e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 45.30 E-value: 4.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 18 TFIMAVGFYMLVPLLAYHFLQDLTLTIAAVAALTAVRTAAQNGMMPIAGWVADRINFRRAILIGVLVRASGFAMLGTVDS 97
Cdd:cd06173 217 LALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPS 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 98 VPLLVVASILTGLGGALFHPASYSAYAALTTGSDRIRVYSTREVVSNVGFIVGPIIGGFLAGADFAFVSLSAAGMFVIAF 177
Cdd:cd06173 297 LWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLA 376
|
....*
gi 1563883176 178 IISAF 182
Cdd:cd06173 377 ALLLL 381
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
213-359 |
9.08e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 44.19 E-value: 9.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 213 ALVAGTAVLVAQFYLV---IPFRAAEFTSGPSDLGFIYSGAAIVMVLTMLPLTGAANRFlPDRVTLAGATTCLGVGVGIM 289
Cdd:COG2814 14 ALALGAFLSGLGIGIVlpaLPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRF-GRRRVLLLGLLLFALGSLLC 92
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 290 GLSTNLFGMLVGVAVFIVGQMLAQPVLNATVSRFAPEGSVASYFGVQGLANAIGGVVGSSSAGVIYALAG 359
Cdd:COG2814 93 ALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
9-184 |
1.55e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 43.41 E-value: 1.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 9 FALKVLYSDTFIMAVGFYMLVPLLAY------HFLQDLTLTIAAVAALTAVRTAAQNgmmPIAGWVADRINFRRAILIGV 82
Cdd:cd17391 201 SLLISLFVTTFIIQLANQSIEPILTLyirqlmGDASNLAFISGLVFSATGVSSLLSA---PRLGKLGDRIGHHRILLGAL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 83 LVRASGFAMLGTVDSVPLLVVASILTGLGGALFHPASYSAYAALTTGSDRIRVYSTREVVSNVGFIVGPIIGGFLAGA-D 161
Cdd:cd17391 278 LASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHfG 357
|
170 180
....*....|....*....|...
gi 1563883176 162 FAFVSLSAAGMFVIAFIISAFGL 184
Cdd:cd17391 358 YRAVFVVTALLVLLNAIWSFIFL 380
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
10-181 |
1.69e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 43.31 E-value: 1.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 10 ALKVLYSDTFIMAVGFYMLVPLLAYHFLQDLTLTIAAVAALTAVRTAAQNGMMPIAGWVADRINFRRAILIGVLVRASGF 89
Cdd:cd17324 199 RLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALL 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 90 AMLGTVDSVPLLVVASILTGLGGALFHPAsYSAYAALTTGSDRIRVYSTREVVSNVGFIVGPIIGG-FLAGADFAFVSLS 168
Cdd:cd17324 279 LLTLLGPSPLLLLVGLVLWGLGFFAAHSA-LQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGlVLDHGGWAGVGWV 357
|
170
....*....|...
gi 1563883176 169 AAGMFVIAFIISA 181
Cdd:cd17324 358 GAALLLLALLLAL 370
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
64-182 |
3.99e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 42.18 E-value: 3.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 64 IAGWVADRINFRRAILIGVLVRASGFAMLGTVDSVPLLVVASILTGLGGALFHPASYSAYAALTTGSDRIRVYSTREVVS 143
Cdd:cd17330 230 LIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQ 309
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1563883176 144 NVGFIVGPIIGGFLAGADFAFVS-LSAAGMFVIAFIISAF 182
Cdd:cd17330 310 SLARIIGPLLAGPLYSFLGPGVPfLLAAGLLLIALFLLSL 349
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
211-386 |
4.92e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 42.03 E-value: 4.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 211 YCALVAGTAVLVAQFYLVIPFRAAEFTSGPSDLGFIYSGAAIVMVLTMLPLTGAANRFLPdRVTLAGATTCLGVGVGIMG 290
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGR-RPVLLLGLLLFALGALLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 291 LSTNLFGMLVGVAVFIVGQMLAQPVLNATVSRFAPEGSVASYFGVQGLANAIGGVVGSSSAGVIYALAGSGEPgasWVWL 370
Cdd:cd06174 80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWR---AVFL 156
|
170
....*....|....*.
gi 1563883176 371 TYPAWAVIVAVLFVVF 386
Cdd:cd06174 157 IAAALALLAAILLLLV 172
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
36-184 |
6.26e-04 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 41.47 E-value: 6.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 36 FLQDLTLTIAAVAAL-TAVRTAAQNGMMPIAGWVADRINFRRAILIGVLVRASGFAMLGTVDSVPLLVVASILTGLGGAL 114
Cdd:cd17393 225 YLRDVLGASAALAALgYAVFSLAMTVGRLFGDRLVDRFGDVAVLRAGALLAALGLLLALLAPSVWVALAGFALMGLGLSV 304
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 115 FHPASYSAYAALTTGSDRIRVySTREVVSNVGFIVGPIIGGFLAGAdfafVSLSAAGMFVIAFIISAFGL 184
Cdd:cd17393 305 VVPLAFSAAGALPGLAAGIAV-ARVATLGYLGFLVGPPLIGFLADA----TGLRTAFLVVALLALLVALL 369
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
63-160 |
6.86e-04 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 41.45 E-value: 6.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 63 PIAGWVADRINFRRAILIGVLVRASGFAMLGTVDSVPLLVVASILTGLGGALFHPASYSAYAALTTGSDRIRVYSTREVV 142
Cdd:cd17328 52 PIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFA 131
|
90
....*....|....*...
gi 1563883176 143 SNVGFIVGPIIGGFLAGA 160
Cdd:cd17328 132 IPLGSGLGYVVGGLVAQA 149
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
19-186 |
7.44e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 41.37 E-value: 7.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 19 FIMAVGFYML----VPLLAYHFlQDLTLTIAAVAALTAVRTAAQNGMMPIAGWVADRINFRRAILIGVLVRASGFAMLGT 94
Cdd:cd17370 205 YLLAVALFALgnfsFAFLILRA-QELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFAL 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 95 VDSVPLLVVASILTGLGGALFHPASYSAYAALTTGSDRIRVYStrevVSNVGFIVGPIIGGFLAGADFAFVSLSAAgmFV 174
Cdd:cd17370 284 GSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYG----LFNTVVGIGWLLASLIAGYLWDLISPSAA--FL 357
|
170
....*....|..
gi 1563883176 175 IAFIISAFGLPG 186
Cdd:cd17370 358 FSAVLALIALLL 369
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
61-157 |
1.73e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 40.25 E-value: 1.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 61 MMPIAGWVADRINFRRAILIGVLVRASGFAMLGTVDSVPLLVVASILTGLGGALFHPASYSAYAALTTGSDRIRVYSTRE 140
Cdd:cd17503 47 MIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVG 126
|
90
....*....|....*..
gi 1563883176 141 VVSNVGFIVGPIIGGFL 157
Cdd:cd17503 127 LVILLAPAIGPTLGGWL 143
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
65-177 |
2.22e-03 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 39.92 E-value: 2.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 65 AGWVADRINFRRAILIGVLVRASGFAMLGTVDSVPLLVVASILTGLGGALFHPASYSAYAALTTGSDR-----IRVYSTR 139
Cdd:cd17313 301 IGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHSESGRgqgtdTGLLNLA 380
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1563883176 140 EVVSN--VGFIVGPIIGGFLAGADFAFVSLSAAGMFVIAF 177
Cdd:cd17313 381 ISLAQilVSLLAGPIIDVKGYGTVFPVAAVASFLSLVGAL 420
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
35-360 |
3.22e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 39.46 E-value: 3.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 35 HFLQDLTLTIAAVAALTAVRTAAQNGMMPIAGWVADRINFRRAILIGVLVRASGFAMLGTVDSVPLLVVA-SILTGLGGA 113
Cdd:cd17352 28 ELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLTyGVLGGLGLG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 114 LFHPAsysAYAALTTGSDRIRVYSTREVVSNVG---FIVGPIIGGFLAGADFAFVSLSAAGMFVIAFIISAFglpgpged 190
Cdd:cd17352 108 LIYSP---AIVIVGQYFEKKRGLATGIAVAGSGvgtFVFPPLLRYLLDNYGWRGALLILGGLCLNLCVCGLL-------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 191 dkartpprLRVaFADLAFVRYCALVAGTAVLVAQFYLVIPFRAAEFTSGPSDLGFIYSGAAIVMVLTMLPLTGAANRFLP 270
Cdd:cd17352 177 --------LRL-LKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRI 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 271 DRVTLAGAT-TCLGVGVGIMGLSTNLFGMLVGVAVFIVGQMLAQPVLNATVSRFAPEGSVASYFGVQGLANAIGGVVGSS 349
Cdd:cd17352 248 GRLYLYIFTlLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPP 327
|
330
....*....|.
gi 1563883176 350 SAGVIYALAGS 360
Cdd:cd17352 328 IAGLLRDYTGD 338
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
1-182 |
4.15e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 39.10 E-value: 4.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 1 MAKRPPVSFALKVLYSDTFIMAVGFYMLVPLLAYHFLQDLTLTIAAVAALTAVRTAAQNGMMPIAGWVADRINFRRAILI 80
Cdd:cd17504 173 LLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLI 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 81 GVLVRASGFAMLGTV-DSVPLLVVASILTGLGGALfhpaSYSAYAALTTGSDRIRVYSTREVVSNVGFIVGPIIGGFLAG 159
Cdd:cd17504 253 GLVISAVGLLLLALLhSSLWALVVALLLIGIGLGL----AFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAG 328
|
170 180 190
....*....|....*....|....*....|
gi 1563883176 160 A-------DFAFVSLSAAGMFVIAFIISAF 182
Cdd:cd17504 329 AilttytvSITSGGVPTEGAYVLAFLIGAA 358
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
62-182 |
5.85e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 38.76 E-value: 5.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 62 MPIAGWVADRINFRRAILIGVLVRASGFAMLGTVDSVPLLVVASILTGLGGALfHPASYSAYAALTTGSDRIRVYSTREV 141
Cdd:cd06179 49 GPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGT-QGLGAAVASELVPNKYRGLVQGVVNL 127
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1563883176 142 VSNVGFIVGPIIGGFLAGADFA---FVSLSAAGMFVIAFIISAF 182
Cdd:cd06179 128 VASPGSALGPLIAGALVEANAAgwrWIFYINAIFNALALILLFF 171
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
227-403 |
6.68e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 38.17 E-value: 6.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 227 LVIPFRAAEFTSGPSDLGFIYSGAAIVMVLTMLPLTGAANRFLPDRVTLAGATTcLGVGVGIMGLSTNLFGMLVGVAVFI 306
Cdd:pfam07690 18 ALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLL-FALGLLLLLFASSLWLLLVLRVLQG 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1563883176 307 VGQMLAQPVLNATVSRFAPEGSVASYFGVQGLANAIGGVVGSSSAGVIYALAgsgepGASWVWLTYPAWAVIVAVLFVVF 386
Cdd:pfam07690 97 LGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF-----GWRAAFLILAILSLLAAVLLLLP 171
|
170
....*....|....*..
gi 1563883176 387 GPRRASGSADSKPSAPQ 403
Cdd:pfam07690 172 RPPPESKRPKPAEEARL 188
|
|
| |
