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Conserved domains on  [gi|156119621|ref|NP_002158|]
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DNA-binding protein inhibitor ID-3 [Homo sapiens]

Protein Classification

DNA-binding protein inhibitor ID-3( domain architecture ID 14444561)

DNA-binding protein inhibitor ID-3 acts as transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity

Gene Ontology:  GO:0046983|GO:0140416|GO:0045892

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
bHLH_dnHLH_ID3 cd19693
basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID3 and similar ...
23-83 2.31e-35

basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID3 and similar proteins; ID3, also termed Class B basic helix-loop-helix protein 25 (bHLHb25), or helix-loop-helix protein HEIR-1, or ID-like protein inhibitor HLH 1R21, or inhibitor of DNA binding 3, or inhibitor of differentiation 3, is a dominant negative helix-loop-helix (dnHLH) transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the bHLH transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. It negatively regulates muscle differentiation by inhibiting the DNA-binding activities of the myogenic regulatory factors.


:

Pssm-ID: 381536  Cd Length: 61  Bit Score: 115.65  E-value: 2.31e-35
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 156119621  23 AIARGRGKGPAAEEPLSLLDDMNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVV 83
Cdd:cd19693    1 SSRNGSNKGPALEEPVSLLYDMNDCYSRLRELVPGVPQGTKLSQVEILQHVIDYILDLQIV 61
 
Name Accession Description Interval E-value
bHLH_dnHLH_ID3 cd19693
basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID3 and similar ...
23-83 2.31e-35

basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID3 and similar proteins; ID3, also termed Class B basic helix-loop-helix protein 25 (bHLHb25), or helix-loop-helix protein HEIR-1, or ID-like protein inhibitor HLH 1R21, or inhibitor of DNA binding 3, or inhibitor of differentiation 3, is a dominant negative helix-loop-helix (dnHLH) transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the bHLH transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. It negatively regulates muscle differentiation by inhibiting the DNA-binding activities of the myogenic regulatory factors.


Pssm-ID: 381536  Cd Length: 61  Bit Score: 115.65  E-value: 2.31e-35
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 156119621  23 AIARGRGKGPAAEEPLSLLDDMNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVV 83
Cdd:cd19693    1 SSRNGSNKGPALEEPVSLLYDMNDCYSRLRELVPGVPQGTKLSQVEILQHVIDYILDLQIV 61
HLH pfam00010
Helix-loop-helix DNA-binding domain;
42-81 6.02e-13

Helix-loop-helix DNA-binding domain;


Pssm-ID: 459628 [Multi-domain]  Cd Length: 53  Bit Score: 58.63  E-value: 6.02e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 156119621   42 DDMNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQ 81
Cdd:pfam00010  14 DRINDAFDELRELLPTLPPDKKLSKAEILRLAIEYIKHLQ 53
HLH smart00353
helix loop helix domain;
42-86 6.55e-13

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 58.38  E-value: 6.55e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 156119621    42 DDMNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVLAE 86
Cdd:smart00353   9 RKINEAFDELRSLLPTLPKNKKLSKAEILRLAIEYIKSLQEELQK 53
 
Name Accession Description Interval E-value
bHLH_dnHLH_ID3 cd19693
basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID3 and similar ...
23-83 2.31e-35

basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID3 and similar proteins; ID3, also termed Class B basic helix-loop-helix protein 25 (bHLHb25), or helix-loop-helix protein HEIR-1, or ID-like protein inhibitor HLH 1R21, or inhibitor of DNA binding 3, or inhibitor of differentiation 3, is a dominant negative helix-loop-helix (dnHLH) transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the bHLH transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. It negatively regulates muscle differentiation by inhibiting the DNA-binding activities of the myogenic regulatory factors.


Pssm-ID: 381536  Cd Length: 61  Bit Score: 115.65  E-value: 2.31e-35
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 156119621  23 AIARGRGKGPAAEEPLSLLDDMNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVV 83
Cdd:cd19693    1 SSRNGSNKGPALEEPVSLLYDMNDCYSRLRELVPGVPQGTKLSQVEILQHVIDYILDLQIV 61
bHLH_dnHLH_ID cd19684
basic helix-loop-helix (bHLH) domain found in the DNA-binding protein inhibitor (ID) family; ...
37-83 3.01e-23

basic helix-loop-helix (bHLH) domain found in the DNA-binding protein inhibitor (ID) family; The ID family includes a dominant negative group of helix-loop-helix (dnHLH) proteins, ID1-4, that are negative regulators of bHLH transcription factors. They contain the HLH-dimerization domain but lack the basic domain necessary for DNA-binding. ID proteins inhibit binding to DNA and transcriptional transactivation by heterodimerization with bHLH proteins. They also interact with many non-bHLH proteins in complex networks. ID proteins have been implicated in regulating gene expression as well as cell-cycle progression. Whereas ID-1, ID-2 and ID-3, are generally considered as tumor promoters, ID4 on the contrary has emerged as a tumor suppressor.


Pssm-ID: 381527  Cd Length: 47  Bit Score: 84.63  E-value: 3.01e-23
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 156119621  37 PLSLLDDMNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVV 83
Cdd:cd19684    1 NDILNAEMQDCYSKLKELVPTIPQNKKVSKVEILQHVIDYILDLQLA 47
bHLH_dnHLH_ID2 cd19692
basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID2 and similar ...
21-84 8.84e-23

basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID2 and similar proteins; ID2, also termed Class B basic helix-loop-helix protein 26 (bHLHb26), or inhibitor of DNA binding 2, or inhibitor of differentiation 2, is a dominant negative helix-loop-helix (dnHLH) transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the bHLH transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. It has been implicated in the regulation of cell proliferation and differentiation in myogenesis, neurogenesis, and/or hematopoiesis.


Pssm-ID: 381535  Cd Length: 66  Bit Score: 83.91  E-value: 8.84e-23
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 156119621  21 SLAIARGrgKGPAaEEPLSLLDDMNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVL 84
Cdd:cd19692    2 SLGISRS--KTPV-DDPMSLLYNMNDCYSKLKELVPSIPQNKKVSKMEILQHVIDYILDLQIAL 62
bHLH_dnHLH_ID1 cd19691
basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID1 and similar ...
40-86 6.92e-18

basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID1 and similar proteins; ID1, also termed Class B basic helix-loop-helix protein 24 (bHLHb24), or inhibitor of DNA binding 1, or inhibitor of differentiation 1, is a dominant negative helix-loop-helix (dnHLH) transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the bHLH transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. ID1 interferes with centrosomal function. It has been implicated in the regulation of cell proliferation and differentiation in myogenesis, neurogenesis, and/or hematopoiesis.


Pssm-ID: 381534  Cd Length: 52  Bit Score: 71.37  E-value: 6.92e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 156119621  40 LLDDMNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVLAE 86
Cdd:cd19691    4 LLYDMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIWDLQVELDS 50
bHLH_dnHLH_ID4 cd19694
basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID4 and similar ...
35-84 4.82e-17

basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID4 and similar proteins; ID4, also termed Class B basic helix-loop-helix protein 27 (bHLHb27), or inhibitor of DNA binding 4, or inhibitor of differentiation 4, is a dominant negative helix-loop-helix (dnHLH) transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the bHLH transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. It plays a role in adipose cell differentiation.


Pssm-ID: 381537  Cd Length: 60  Bit Score: 69.27  E-value: 4.82e-17
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 156119621  35 EEPLSLLDDMNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVL 84
Cdd:cd19694    2 EEALCLQYDMNDCYSRLKRLVPTIPPNKKVSKVEILQHVIDYILDLQLAL 51
HLH pfam00010
Helix-loop-helix DNA-binding domain;
42-81 6.02e-13

Helix-loop-helix DNA-binding domain;


Pssm-ID: 459628 [Multi-domain]  Cd Length: 53  Bit Score: 58.63  E-value: 6.02e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 156119621   42 DDMNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQ 81
Cdd:pfam00010  14 DRINDAFDELRELLPTLPPDKKLSKAEILRLAIEYIKHLQ 53
HLH smart00353
helix loop helix domain;
42-86 6.55e-13

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 58.38  E-value: 6.55e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 156119621    42 DDMNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVLAE 86
Cdd:smart00353   9 RKINEAFDELRSLLPTLPKNKKLSKAEILRLAIEYIKSLQEELQK 53
bHLH_dnHLH_EMC_like cd19695
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein ...
48-87 7.45e-12

basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein extra-macrochaetae and similar proteins; Extra-macrochaetae is a negative regulator of sensory organ development in Drosophila. It belongs to dominant negative group of helix-loop-helix (dnHLH) proteins, which lack a basic DNA-binding domain but can form heterodimers with other HLH proteins, thereby inhibiting DNA binding.


Pssm-ID: 381538  Cd Length: 52  Bit Score: 55.84  E-value: 7.45e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 156119621  48 YSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVLAEP 87
Cdd:cd19695   12 LAKLRNLVPTLPKNRKVSKLELLQHVIDYIADLEEQLEDH 51
bHLH_SF cd00083
basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators ...
42-81 1.85e-10

basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. Members of the bHLH superfamily have two highly conserved and functionally distinct regions. The basic part is at the amino end of the bHLH that may bind DNA to a consensus hexanucleotide sequence known as the E box (CANNTG). Different families of bHLH proteins recognize different E-box consensus sequences. At the carboxyl-terminal end of the region is the HLH region that interacts with other proteins to form homo- and heterodimers. bHLH proteins function as a diverse set of regulatory factors because they recognize different DNA sequences and dimerize with different proteins. The bHLH proteins can be divided to cell-type specific and widely expressed proteins. The cell-type specific members of bHLH superfamily are involved in cell-fate determination and act in neurogenesis, cardiogenesis, myogenesis, and hematopoiesis.


Pssm-ID: 381392 [Multi-domain]  Cd Length: 46  Bit Score: 52.14  E-value: 1.85e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 156119621  42 DDMNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQ 81
Cdd:cd00083    6 DKINDAFEELKRLLPELPDSKKLSKASILQKAVEYIRELQ 45
bHLH_TS_ASCL cd11418
basic helix-loop-helix (bHLH) domain found in achaete-scute complex-like (ASCL) family; The ...
45-84 2.17e-08

basic helix-loop-helix (bHLH) domain found in achaete-scute complex-like (ASCL) family; The achaete-scute complex-like (ASCL, also known as achaete-scute complex homolog or ASH) family of bHLH transcription factors, ASCL1-5, have been implicated in cell fate specification and differentiation. They are critical for proper development of the nervous system. The deregulation of ASCL plays a key role in psychiatric and neurological disorders. ASCL-1, also termed Class A basic helix-loop-helix protein 46 (bHLHa46), or achaete-scute homolog 1 (ASH-1), or mammalian achaete-scute homolog 1 (Mash1), is a neural-specific bHLH transcription factor that is expressed in subsets of neural progenitors in both the central and peripheral nervous system. It plays a key role in neuronal differentiation and specification in the nervous system. ASCL-2, also termed achaete-scute homolog 2 (ASH-2), or Class A basic helix-loop-helix protein 45 (bHLHa45), or mammalian achaete-scute homolog 2 (Mash2), is a bHLH transcription factor that is involved in Schwann cell differentiation and control of proliferation in adult peripheral nerves. ASCL-3, also termed Class A basic helix-loop-helix protein 42 (bHLHa42), or bHLH transcriptional regulator Sgn-1, or achaete-scute homolog 3 (ASH-3), is a bHLH transcription factor specifically localized in the duct cells of the salivary glands. It may act as transcriptional repressor that inhibits myogenesis. The family also includes Drosophila melanogaster achaete-scute complex (AS-C) proteins, which consists of lethal of scute (also known as achaete-scute complex protein T3 or AST3), scute (also known as achaete-scute complex protein T4 or AST4), achaete (also known as achaete-scute complex protein T5 or AST5), and asense (also known as achaete-scute complex protein T8 or AST8). They are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system, as well as in sex determination and dosage compensation.


Pssm-ID: 381424 [Multi-domain]  Cd Length: 56  Bit Score: 46.83  E-value: 2.17e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 156119621  45 NHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVL 84
Cdd:cd11418   17 NDAFDRLRQHVPYLKRRKKLSKVKTLRRAIEYIRHLQKLL 56
bHLH_TS cd11390
tissue specific basic helix-loop-helix (bHLH-TS) domain family; Tissue specific bHLH domain ...
43-84 2.71e-07

tissue specific basic helix-loop-helix (bHLH-TS) domain family; Tissue specific bHLH domain family includes transcription regulators whose expression are restricted to certain tissues. They are involved in cell-fate determination and process in neurogenesis, cardiogenesis, myogenesis, and hematopoiesis and include proteins from myogenic regulatory factor (MRF) family, twist-related protein (TWIST) family, scleraxis-like family, heart- and neural crest derivatives-expressed protein (HAND) family, helix-loop-helix protein (HEN) family, musculin-like family, germline alpha (FIGLA) family, T-cell acute lymphocytic leukemia protein/ lymphoblastic leukemia-derived sequence (TAL/LYL) family, ovary, uterus and testis protein (OUT) family, mesoderm posterior protein (Mesp) family, muscle, intestine and stomach expression 1 (MIST-1) family, protein atonal homologs (ATOH) family, neurogenin (NGN) family, neurogenic differentiation factor (NeuroD) family, achaete-scute complex-like (ASCL) family, Fer3-like protein (FERD3L)-like family, and Oligodendrocyte lineage genes (OLIG) family of transcription factors.


Pssm-ID: 381396 [Multi-domain]  Cd Length: 55  Bit Score: 44.10  E-value: 2.71e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 156119621  43 DMNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVL 84
Cdd:cd11390   14 DLNDAFEALRKVLPTVPPDKKLSKIETLRLAINYIAALSDLL 55
bHLH_TS_HAND1 cd18952
basic helix-loop-helix (bHLH) domain found in heart- and neural crest derivatives-expressed ...
26-86 1.46e-06

basic helix-loop-helix (bHLH) domain found in heart- and neural crest derivatives-expressed protein 1 (HAND1) and similar proteins; HAND1, also termed Class A basic helix-loop-helix protein 27 (bHLHa27), or extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1 (eHAND), is a bHLH transcription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis.


Pssm-ID: 381522 [Multi-domain]  Cd Length: 60  Bit Score: 42.32  E-value: 1.46e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 156119621  26 RGRGKGPAAEEPLSllDDMNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVLAE 86
Cdd:cd18952    1 RRKGAGPKKERRRT--ESINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDVLAK 59
bHLH_TS_ASCL1_like cd19723
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster achaete-scute complex ...
45-84 3.36e-06

basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster achaete-scute complex (AS-C) proteins, achaete-scute-like proteins, ASCL1-2, and similar proteins; This subfamily includes Drosophila melanogaster AS-C proteins and two ASCL family of transcription factors, ASCL-1 and ASCL-2. Drosophila melanogaster AS-C proteins includes lethal of scute (also known as achaete-scute complex protein T3 or AST3), scute (also known as achaete-scute complex protein T4 or AST4), achaete (also known as achaete-scute complex protein T5 or AST5), and asense (also known as achaete-scute complex protein T8 or AST8). They are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system, as well as in sex determination and dosage compensation. ASCL-1, also termed Class A basic helix-loop-helix protein 46 (bHLHa46), or achaete-scute homolog 1 (ASH-1), or mammalian achaete scute homolog 1 (Mash1), is expressed in subsets of neural progenitors in both the central and peripheral nervous system. It plays a key role in neuronal differentiation and specification in the nervous system. ASCL-2, also termed achaete-scute homolog 2 (ASH-2), or Class A basic helix-loop-helix protein 45 (bHLHa45), or mammalian achaete scute homolog 2 (Mash2), is involved in Schwann cell differentiation and control of proliferation in adult peripheral nerves.


Pssm-ID: 381566  Cd Length: 56  Bit Score: 41.28  E-value: 3.36e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 156119621  45 NHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVL 84
Cdd:cd19723   17 NLGFATLREHVPNGRANKKMSKVETLRSAVEYIRQLQQLL 56
bHLH_TS_FIGLA cd11422
basic helix-loop-helix (bHLH) domain found in factor in the germline alpha (FIGLA) and similar ...
44-84 7.01e-06

basic helix-loop-helix (bHLH) domain found in factor in the germline alpha (FIGLA) and similar proteins; FIGLA, also termed FIGalpha, or Class C basic helix-loop-helix protein 8 (bHLHc8), or folliculogenesis-specific basic helix-loop-helix protein, or transcription factor FIGa, is a germ-cell-specific bHLH transcription factor expressed abundantly in female and less so in male germ cells. It is essential for primordial follicle formation and expression of many genes required for folliculogenesis, fertilization and early embryonic survival. FIGLA knockout mice cannot form primordial follicles and lose oocytes rapidly after birth, whereas male gonads are unaffected.


Pssm-ID: 381428  Cd Length: 56  Bit Score: 40.41  E-value: 7.01e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 156119621  44 MNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVL 84
Cdd:cd11422   15 LNSGFSKLRRIVPLIPRDRKPSKVDTLKGATEYIRLLQRIL 55
bHLH_TS_ATOH7 cd19714
basic helix-loop-helix (bHLH) domain found in protein atonal homolog 7 (ATOH7) and similar ...
21-86 2.97e-05

basic helix-loop-helix (bHLH) domain found in protein atonal homolog 7 (ATOH7) and similar proteins; ATOH7, also termed Class A basic helix-loop-helix protein 13 (bHLHa13), or helix-loop-helix protein hATH-5 (hATH5), or Math5, is a bHLH transcription factor involved in the differentiation of retinal ganglion cells.


Pssm-ID: 381557 [Multi-domain]  Cd Length: 69  Bit Score: 39.16  E-value: 2.97e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 156119621  21 SLAIARGRGKGPAAEEPlSLLDDMNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVLAE 86
Cdd:cd19714    1 RLESAARRRLAANARER-RRMQGLNTAFDRLRKVVPQWGQDKKLSKYETLQMALSYIMALTRILAE 65
bHLH_TS_ATOH1_like cd11430
basic helix-loop-helix (bHLH) domain found in protein atonal homologs ATOH1, ATOH7 and similar ...
44-84 7.18e-05

basic helix-loop-helix (bHLH) domain found in protein atonal homologs ATOH1, ATOH7 and similar proteins; The family includes ATOH1 and ATOH7. ATOH1, also termed Class A basic helix-loop-helix protein 14 (bHLHa14), or helix-loop-helix protein hATH-1 (hATH1), or Math1, or Cath1, is a proneural bHLH transcription factor that is essential for inner ear hair cell differentiation. It dimerizes with E47 and activates E-box (CANNTG) dependent transcription. ATOH1 is a mammalian homolog of the Drosophila melanogaster gene atonal and mouse atonal homolog 1 (Math1). ATOH7, also termed Class A basic helix-loop-helix protein 13 (bHLHa13), or helix-loop-helix protein hATH-5 (hATH5), or Math5, is a bHLH transcription factor involved in the differentiation of retinal ganglion cells. The family also includes protein Amos (also termed absent MD neurons and olfactory sensilla protein, or reduced olfactory organs protein, or rough eye protein). It is a bHLH transcription factor that promotes multiple dendritic neuron formation in the Drosophila peripheral nervous system.


Pssm-ID: 381436 [Multi-domain]  Cd Length: 56  Bit Score: 37.80  E-value: 7.18e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 156119621  44 MNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVL 84
Cdd:cd11430   16 LNRAFDQLRSVVPSIGNDKKLSKYETLQMAQIYIETLSELL 56
bHLH_TS_HAND2 cd11471
basic helix-loop-helix (bHLH) domain found in heart- and neural crest derivatives-expressed ...
44-89 1.11e-04

basic helix-loop-helix (bHLH) domain found in heart- and neural crest derivatives-expressed protein 2 (HAND2) and similar proteins; HAND2, also termed Class A basic helix-loop-helix protein 26 (bHLHa26), or deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2 (dHAND), is a bHLH transcription factor that is essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries.


Pssm-ID: 381477 [Multi-domain]  Cd Length: 62  Bit Score: 37.73  E-value: 1.11e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 156119621  44 MNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVLAEPAP 89
Cdd:cd11471   16 INSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDLLAKDDQ 61
bHLH_TS_ASCL3_like cd19724
basic helix-loop-helix (bHLH) domain found in achaete-scute-like proteins, ASCL3-5, and ...
45-84 1.52e-04

basic helix-loop-helix (bHLH) domain found in achaete-scute-like proteins, ASCL3-5, and similar proteins; This subfamily includes three ASCL family of transcription factors, ASCL-3, ASCL-4 and ASCL-5. ASCL-3, also termed Class A basic helix-loop-helix protein 42 (bHLHa42), or bHLH transcriptional regulator Sgn-1, or achaete-scute homolog 3 (ASH-3), is specifically localized in the duct cells of the salivary glands. It may act as transcriptional repressor that inhibits myogenesis. ASCL-4, also termed Class A basic helix-loop-helix protein 44 (bHLHa44), or achaete-scute homolog 4 (ASH-4), or Hash4, may be involved in skin development. ASCL-5, also termed Class A basic helix-loop-helix protein 47 (bHLHa47), or achaete-scute homolog 5 (ASH-5), is an uncharacterized bHLH transcription factor that is close related to ASCL-3 and ASCL-4.


Pssm-ID: 381567  Cd Length: 56  Bit Score: 36.89  E-value: 1.52e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 156119621  45 NHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVL 84
Cdd:cd19724   17 NEGYARLRRHLPLENKDKRLSKVETLRAAIRYIKHLQELL 56
bHLH_TS_ASCL4 cd19746
basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 4 (ASCL-4) and ...
44-84 5.58e-04

basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 4 (ASCL-4) and similar proteins; ASCL-4, also termed Class A basic helix-loop-helix protein 44 (bHLHa44), or achaete-scute homolog 4 (ASH-4), or Hash4, is a bHLH transcriptional regulator that may be involved in skin development.


Pssm-ID: 381589  Cd Length: 64  Bit Score: 35.78  E-value: 5.58e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 156119621  44 MNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVL 84
Cdd:cd19746   23 VNEGYARLREHLPQELADKRLSKVETLRAAIDYIKHLQELL 63
bHLH_AtbHLH_like cd11393
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana genes coding transcription ...
42-81 8.42e-04

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana genes coding transcription factors and similar proteins; bHLH proteins are the second largest class of plant transcription factors that regulate transcription of genes that are involve in many essential physiological and developmental process. bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. The Arabidopsis bHLH proteins that have been characterized so far have roles in regulation of fruit dehiscence, cell development (carpel, anther and epidermal), phytochrome signaling, flavonoid biosynthesis, hormone signaling and stress responses.


Pssm-ID: 381399 [Multi-domain]  Cd Length: 53  Bit Score: 34.85  E-value: 8.42e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 156119621  42 DDMNHCYSRLRELVPGvprGTQLSQVEILQRVIDYILDLQ 81
Cdd:cd11393   10 EKINERIRALRSLVPN---GGKTDKASILDEAIEYIKFLQ 46
bHLH_TS_HAND cd11466
basic helix-loop-helix (bHLH) domain found in heart- and neural crest derivatives-expressed ...
44-84 9.27e-04

basic helix-loop-helix (bHLH) domain found in heart- and neural crest derivatives-expressed protein (HAND) family; The HAND family includes two bHLH transcription factors, HAND1 and HAND2. HAND1, also termed Class A basic helix-loop-helix protein 27 (bHLHa27), or extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1 (eHAND), plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. HAND2, also termed Class A basic helix-loop-helix protein 26 (bHLHa26), or deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2 (dHAND), is essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries.


Pssm-ID: 381472 [Multi-domain]  Cd Length: 56  Bit Score: 35.07  E-value: 9.27e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 156119621  44 MNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVL 84
Cdd:cd11466   16 INSAFADLRECIPNVPADTKLSKIKTLRLATSYIAYLMDVL 56
bHLH_TS_ASCL5 cd19747
basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 5 (ASCL-5) and ...
44-84 1.05e-03

basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 5 (ASCL-5) and similar proteins; ASCL-5, also termed Class A basic helix-loop-helix protein 47 (bHLHa47), or achaete-scute homolog 5 (ASH-5), is an uncharacterized bHLH transcription factor that belongs to AS-C (achaete, scute, lethal of scute, and asense) family.


Pssm-ID: 381590  Cd Length: 61  Bit Score: 34.98  E-value: 1.05e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 156119621  44 MNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVL 84
Cdd:cd19747   21 VNEGYARLRDHLPGAMAEKRLSKVETLRAAIRYIKYLQDLL 61
bHLH_AtPRE_like cd11442
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana paclobutrazol resistance ...
48-84 1.29e-03

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana paclobutrazol resistance (PRE) family; The PRE family includes several bHLH transcription factors from Arabidopsis thaliana, such as PRE1-6. PRE1 (also termed AtbHLH136, or protein banquo 1), PRE2 (also termed AtbHLH134, or protein banquo 2, or EN 52), PRE4 (also termed AtbHLH161, or protein banquo 3), and PRE5 (also termed AtbHLH164) are atypical and probable non DNA-binding bHLH transcription factors that integrate multiple signaling pathways to regulate cell elongation and plant development. PRE3 (also termed AtbHLH135, or protein activation-tagged BRI1 suppressor 1, or ATBS1, or protein target of MOOPTEROS 7, or EN 67) is an atypical and probable non DNA-binding bHLH transcription factor required for MONOPTEROS-dependent root initiation in embryo. It promotes the correct definition of the hypophysis cell division plane. PRE5 (also termed AtbHLH163, or protein KIDARI) is an atypical and probable non DNA-binding bHLH transcription factor that regulates light-mediated responses in day light conditions by binding and inhibiting the activity of the bHLH transcription factor HFR1, a critical regulator of light signaling and shade avoidance.


Pssm-ID: 381448  Cd Length: 65  Bit Score: 34.59  E-value: 1.29e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 156119621  48 YSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVL 84
Cdd:cd11442   16 YSRLRALLPSIATSDKVSKATVLEEACNYIRNLHREV 52
bHLH_TS_TAL_LYL cd11413
basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein/ ...
43-86 1.69e-03

basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein/ lymphoblastic leukemia-derived sequence (TAL/LYL) family; The TAL/LYL family includes a group of bHLH transcription factors (TAL1, TAL2 and LYL1) implicated in T cell acute leukaemia. They act as mediators of T cell leukaemogenesis. TAL-1, also termed Class A basic helix-loop-helix protein 17 (bHLHa17), or stem cell protein (SCL), or T-cell leukemia/lymphoma protein 5, is a hematopoietic-specific bHLH transcription factor that functions in embryonic and adult hematopoiesis in vertebrates. It is also required for embryonic vascular remodeling. It acts as a regulator of erythroid differentiation and binds to regulatory regions of a large cohort of erythroid genes as part of a complex with GATA-1, LMO2 and Ldb1. TAL-2, also termed Class A basic helix-loop-helix protein 19 (bHLHa19), is a bHLH transcription factor essential for the normal brain development. Lyl-1, also termed Class A basic helix-loop-helix protein 18 (bHLHa18), or lymphoblastic leukemia-derived sequence 1, is a proto-oncogenic bHLH transcription factor that plays an important role in hematopoietic stem cell function and is required for the late stages of postnatal angiogenesis to limit the formation of new blood vessels, notably by regulating the activity of the small GTPase Rap1. LYL-1 deficiency induces a stress erythropoiesis.


Pssm-ID: 381419 [Multi-domain]  Cd Length: 60  Bit Score: 34.35  E-value: 1.69e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 156119621  43 DMNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVLAE 86
Cdd:cd11413   15 NVNGAFAELRKLIPTHPPDKKLSKNEILRLAMKYIKFLEKILED 58
bHLH_TS_dHLH3B_like cd19708
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster helix loop helix protein ...
43-84 1.82e-03

basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster helix loop helix protein 3B (dHLH3B) and similar proteins; Drosophila HLH3B is an uncharacterized bHLH transcription factor that belongs to the T-cell acute lymphocytic leukemia protein/ lymphoblastic leukemia-derived sequence (TAL/LYL) family.


Pssm-ID: 381551 [Multi-domain]  Cd Length: 60  Bit Score: 34.48  E-value: 1.82e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 156119621  43 DMNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVL 84
Cdd:cd19708   15 NVNGAFAELRKLVPTHPPDKKLSKNEILRLAIKYIRLLSNVL 56
bHLH_TS_ASCL2_Mash2 cd19743
basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 2 (ASCL-2) and ...
44-86 2.15e-03

basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 2 (ASCL-2) and similar proteins; ASCL-2, also termed achaete-scute homolog 2 (ASH-2), or Class A basic helix-loop-helix protein 45 (bHLHa45), or mammalian achaete scute homolog 2 (Mash2), is a bHLH transcription factor that is involved in Schwann cell differentiation and control of proliferation in adult peripheral nerves.


Pssm-ID: 381586  Cd Length: 64  Bit Score: 34.17  E-value: 2.15e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 156119621  44 MNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVLAE 86
Cdd:cd19743   18 VNLGFAALRQHVPQGGASKKMSKVETLRSAVEYIRALQRLLGE 60
bHLHzip_spESC1_like cd19690
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Schizosaccharomyces pombe ESC1 (spESC1) ...
43-81 2.57e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Schizosaccharomyces pombe ESC1 (spESC1) and similar proteins; spESC1 is a bHLHzip protein with homology to human MyoD and Myf-5 myogenic differentiation inducers. It is involved in the sexual differentiation process.


Pssm-ID: 381533  Cd Length: 65  Bit Score: 33.97  E-value: 2.57e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 156119621  43 DMNHCYSRLRELVPgVPRGTQLSQVEILQRVIDYILDLQ 81
Cdd:cd19690   14 EMKELFEDLRDALP-QERGTKASKWEILTKAISYIQQLK 51
bHLHzip_Myc cd11400
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the Myc family; The Myc family is a ...
42-81 2.62e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the Myc family; The Myc family is a member of the bHLHzip family of transcription factors that play important roles in the control of normal cell proliferation, growth, survival and differentiation. All Myc isoforms contain two independently functioning polypeptide chain regions: N-terminal transactivating residues and a C-terminal bHLHzip segment. The bHLHzip family of bHLH transcription factors are characterized by a highly conserved N-terminal basic region that may bind DNA at a consensus hexanucleotide sequence known as the E-box (CANNTG) followed by HLH and leucine zipper motifs that may interact with other proteins to form homo- and heterodimers. Myc heterodimerizes with Max enabling specific binding to E-box DNA sequences in the promoters of target genes. The Myc proto-oncoprotein family includes at least five different functional members: c-, N-, L-, S- and B-Myc (which is lacking the bHLH domain).


Pssm-ID: 381406 [Multi-domain]  Cd Length: 80  Bit Score: 34.44  E-value: 2.62e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 156119621  42 DDMNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQ 81
Cdd:cd11400   14 NDLKNSFEKLRDLVPELADNEKASKVVILKKATEYIKQLQ 53
bHLH_TS_musculin cd19703
basic helix-loop-helix (bHLH) domain found in musculin and similar proteins; Musculin, also ...
18-86 3.90e-03

basic helix-loop-helix (bHLH) domain found in musculin and similar proteins; Musculin, also termed activated B-cell factor 1 (ABF-1), or Class A basic helix-loop-helix protein 22 (bHLHa22), is a bHLH transcription factor expressed in activated B lymphocytes. It acts as a transcription repressor capable of inhibiting the transactivation capability of TCF3/E47. Musculin may play a role in regulating antigen-dependent B-cell differentiation. The mouse homolog, musculin, is suggested to be a repressor of myogenesis that is expressed in developing muscle and in the spleen. Musculin heterodimerizes with products of the E2A gene.


Pssm-ID: 381546 [Multi-domain]  Cd Length: 66  Bit Score: 33.58  E-value: 3.90e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 156119621  18 SERSLAIARGRGKgpaaeeplslLDDMNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVLAE 86
Cdd:cd19703    3 SQRNAANARERAR----------MRVLSKAFSRLKTSLPWVPPDTKLSKLDTLRLASSYIAHLRQLLQE 61
bHLH_TS_HEN cd11414
basic helix-loop-helix (bHLH) domain found in helix-loop-helix protein (HEN) family; The HEN ...
45-84 4.46e-03

basic helix-loop-helix (bHLH) domain found in helix-loop-helix protein (HEN) family; The HEN family includes two neuron-specific bHLH transcription factors, HEN-1 (also known as Nhlh1 or bHLHa35 or NSCL-1) and HEN-2 (also known as Nhlh2 or bHLHa34 or NSCL-2). They may serve as DNA-binding protein that is involved in the control of cell-type determination, possibly within the developing nervous system.


Pssm-ID: 381420  Cd Length: 57  Bit Score: 33.26  E-value: 4.46e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 156119621  45 NHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVL 84
Cdd:cd11414   18 NSAFAQLRKLLPTLPPDKKLSKIEILRLAICYISYLNHVL 57
bHLH-O_HERP_HES cd19685
basic helix-loop-helix-orange (bHLH-O) domain found in HERP/HES-like family; The HERP/HES-like ...
44-81 4.73e-03

basic helix-loop-helix-orange (bHLH-O) domain found in HERP/HES-like family; The HERP/HES-like family includes bHLH-O transcriptional regulators that are related to the Drosophila hairy and Enhancer-of-split (HES) proteins. The HERP (HES-related repressor protein) subfamily proteins contain a basic helix-loop-helix (bHLH) domain with an invariant glycine residue in its basic region, an orange domain in the central region and YXXW sequence motif at its C-terminal region. Hairy and enhancer of split (HES)-related repressor protein (HERP) proteins (HEY1, HEY2 and HEYL) act as downstream effectors of Notch signaling. They are involved in cardiovascular development and have roles in somitogenesis, myogenesis and gliogenesis. Hairy and enhancer of split-related protein HELT is a transcriptional repressor expressed in the developing central nervous system. It binds preferentially to the canonical E box sequence 5'-CACGCG-3' and regulates neuronal differentiation and/or identity. Differentially expressed in chondrocytes proteins, DEC1 and DEC2, are widely expressed in both embryonic and adult tissues and have been implicated in apoptosis, cell proliferation, and circadian rhythms, as well as malignancy in various cancers. Drosophila melanogaster protein clockwork orange (Cwo) is also included in this subfamily. It is involved in the regulation of Drosophila circadian rhythms. It functions as both an activator and a repressor of clock gene expression. The HES subfamily proteins contain a basic helix-loop-helix (bHLH) domain with an invariant proline residue in its basic region, an orange domain in the central region and a conserved tetrapeptide motif, WRPW, at its C-terminal region. They form heterodimers or homodimers via their HLH domain and bind DNA to repress gene transcription that play an essential role in development of both compartment and boundary cells of the central nervous system.


Pssm-ID: 381528 [Multi-domain]  Cd Length: 52  Bit Score: 33.17  E-value: 4.73e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 156119621  44 MNHCYSRLRELVP---GVPRGTQLSQVEILQRVIDYILDLQ 81
Cdd:cd19685    9 INDKLNQLKELLPpnlSKQSRSKLSKAEILEMAITELRRLQ 49
bHLH_TS_HEN1 cd19701
basic helix-loop-helix (bHLH) domain found in helix-loop-helix protein 1 (HEN-1) and similar ...
41-84 5.52e-03

basic helix-loop-helix (bHLH) domain found in helix-loop-helix protein 1 (HEN-1) and similar proteins; HEN-1, also termed nescient helix-loop-helix 1 (Nhlh1), or Class A basic helix-loop-helix protein 35 (bHLHa35), or nescient helix loop helix 1 (NSCL-1), is a neuron-specific bHLH transcription factor that may serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system.


Pssm-ID: 381544 [Multi-domain]  Cd Length: 72  Bit Score: 33.48  E-value: 5.52e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 156119621  41 LDDMNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVL 84
Cdd:cd19701   28 VEAFNVAFAELRKLLPTLPPDKKLSKIEILRLAICYISYLNHVL 71
bHLH-O_HERP cd11407
basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split (HES) ...
42-81 5.75e-03

basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split (HES)-related repressor protein (HERP) family; HERP (also called Hey/Hesr/HRT/CHF/gridlock) proteins corresponds to a family of bHLH-O transcriptional repressors that are related to the Drosophila hairy and Enhancer-of-split proteins and act as downstream effectors of Notch signaling. They contain a basic helix-loop-helix (bHLH) domain with an invariant glycine residue in its basic region, an orange domain in the central region and YXXW sequence motif at its C-terminal region. HERP proteins are involved in cardiovascular development and have roles in somitogenesis, myogenesis and gliogenesis.


Pssm-ID: 381413 [Multi-domain]  Cd Length: 59  Bit Score: 32.78  E-value: 5.75e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 156119621  42 DDMNHCYSRLRELVPGV--PRGTQ-LSQVEILQRVIDYILDLQ 81
Cdd:cd11407   14 DRINNSLAELRRLVPTAfeKQGSAkLEKAEILQMTVDHLKMLH 56
bHLH_TS_ASCL3 cd19745
basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 3 (ASCL-3) and ...
44-84 8.00e-03

basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 3 (ASCL-3) and similar proteins; ASCL-3, also termed Class A basic helix-loop-helix protein 42 (bHLHa42), or bHLH transcriptional regulator Sgn-1, or achaete-scute homolog 3 (ASH-3), is a bHLH transcription factor specifically localized in the duct cells of the salivary glands. It may act as transcriptional repressor that inhibits myogenesis.


Pssm-ID: 381588  Cd Length: 59  Bit Score: 32.53  E-value: 8.00e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 156119621  44 MNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVL 84
Cdd:cd19745   19 VNEGYAKLRRHLPQEYSEKRLSKVETLRAAIKYIKHLQSVL 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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