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Conserved domains on  [gi|156104862|ref|NP_859063|]
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KN motif and ankyrin repeat domain-containing protein 4 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
813-988 1.01e-34

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 134.70  E-value: 1.01e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156104862 813 LKLLVNLADHNGNTALHYSVSHSNFSIVKLLLETGVcNVDHQNKAGYTAVMitpLASAETNEDMAvvwKLLRE--GNVNI 890
Cdd:COG0666   76 AGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGA-DVNARDKDGETPLH---LAAYNGNLEIV---KLLLEagADVNA 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156104862 891 QaTQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPAcDSSLTDKAGRTALSIA 970
Cdd:COG0666  149 Q-DNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA-DVNAKDNDGKTALDLA 226

                        170
                 ....*....|....*...
gi 156104862 971 LKSPtHMEIAGLLRAHAE 988
Cdd:COG0666  227 AENG-NLEIVKLLLEAGA 243
KN_motif pfam12075
KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the ...
 24-62 2.74e-20

KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the KN (for Kank N-terminal) motif. This protein is found in eukaryotes. Proteins in this family are typically between 413 to 1202 amino acids in length. This protein is found associated with pfam00023. This protein has two conserved sequence motifs: TPYG and LDLDF. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors.


:

Pssm-ID: 432311  Cd Length: 39  Bit Score: 84.71  E-value: 2.74e-20
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 156104862   24 PYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRAK 62
Cdd:pfam12075   1 PYSVETPYGFHLDLDFLKYVEDIESGQTIRRARVQRRPR 39
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
341-411 3.88e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


:

Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 44.12  E-value: 3.88e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 156104862 341 SISSLKQQVSALEGELSGRTEELAQVRTALQQQEEEIKAREQRIREL--EFTVAQLEGQFHQENAKDTQGQTD 411
Cdd:COG4372   39 ELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELneQLQAAQAELAQAQEELESLQEEAE 111
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
813-988 1.01e-34

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 134.70  E-value: 1.01e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156104862 813 LKLLVNLADHNGNTALHYSVSHSNFSIVKLLLETGVcNVDHQNKAGYTAVMitpLASAETNEDMAvvwKLLRE--GNVNI 890
Cdd:COG0666   76 AGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGA-DVNARDKDGETPLH---LAAYNGNLEIV---KLLLEagADVNA 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156104862 891 QaTQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPAcDSSLTDKAGRTALSIA 970
Cdd:COG0666  149 Q-DNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA-DVNAKDNDGKTALDLA 226

                        170
                 ....*....|....*...
gi 156104862 971 LKSPtHMEIAGLLRAHAE 988
Cdd:COG0666  227 AENG-NLEIVKLLLEAGA 243
KN_motif pfam12075
KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the ...
 24-62 2.74e-20

KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the KN (for Kank N-terminal) motif. This protein is found in eukaryotes. Proteins in this family are typically between 413 to 1202 amino acids in length. This protein is found associated with pfam00023. This protein has two conserved sequence motifs: TPYG and LDLDF. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors.


Pssm-ID: 432311  Cd Length: 39  Bit Score: 84.71  E-value: 2.74e-20
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 156104862   24 PYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRAK 62
Cdd:pfam12075   1 PYSVETPYGFHLDLDFLKYVEDIESGQTIRRARVQRRPR 39
Ank_2 pfam12796
Ankyrin repeats (3 copies);
900-986 1.06e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 73.23  E-value: 1.06e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156104862  900 LMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPACDSsltDKAGRTALSIALKSpTHMEI 979
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL---KDNGRTALHYAARS-GHLEI 76


                  ....*..
gi 156104862  980 AGLLRAH 986
Cdd:pfam12796  77 VKLLLEK 83
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 817-987 7.32e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 71.92  E-value: 7.32e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156104862 817 VNLADHNGNTALHYSVSHSNFSIVKLLLETGV-CNVDHQNKAgytavmiTPLASAETNEDMAVVWKLLREGNVNIQATQG 895
Cdd:PHA02874 150 VNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAyANVKDNNGE-------SPLHNAAEYGDYACIKLLIDHGNHIMNKCKN 222

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156104862 896 GQTALMLGVSHDREdmVQALLSCQADVNLQDHDGSSALmvacHHG-----NVDLVRLLLAHPAcDSSLTDKAGRTALSIA 970
Cdd:PHA02874 223 GFTPLHNAIIHNRS--AIELLINNASINDQDIDGSTPL----HHAinppcDIDIIDILLYHKA-DISIKDNKGENPIDTA 295

                        170
                 ....*....|....*..
gi 156104862 971 LKSPTHMEIAGLLRAHA 987
Cdd:PHA02874 296 FKYINKDPVIKDIIANA 312
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
341-411 3.88e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 44.12  E-value: 3.88e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 156104862 341 SISSLKQQVSALEGELSGRTEELAQVRTALQQQEEEIKAREQRIREL--EFTVAQLEGQFHQENAKDTQGQTD 411
Cdd:COG4372   39 ELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELneQLQAAQAELAQAQEELESLQEEAE 111
ATG16 pfam08614
Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for ...
 335-395 4.74e-04

Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for eukaryotic cells. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. ATG16 (also known as Apg16) has been shown to be bind to Apg5 and is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway.


Pssm-ID: 462536 [Multi-domain]  Cd Length: 176  Bit Score: 42.23  E-value: 4.74e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 156104862  335 ARVDPGSISSLKQQVSALEGELSG----RTEELAQVRTA---LQQQEEEIKAREQRIRELEFTVAQLE 395
Cdd:pfam08614  45 ASPQSASIQSLEQLLAQLREELAElyrsRGELAQRLVDLneeLQELEKKLREDERRLAALEAERAQLE 112
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 823-848 1.65e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 1.65e-03
                           10        20
                   ....*....|....*....|....*.
gi 156104862   823 NGNTALHYSVSHSNFSIVKLLLETGV 848
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGA 26
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
813-988 1.01e-34

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 134.70  E-value: 1.01e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156104862 813 LKLLVNLADHNGNTALHYSVSHSNFSIVKLLLETGVcNVDHQNKAGYTAVMitpLASAETNEDMAvvwKLLRE--GNVNI 890
Cdd:COG0666   76 AGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGA-DVNARDKDGETPLH---LAAYNGNLEIV---KLLLEagADVNA 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156104862 891 QaTQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPAcDSSLTDKAGRTALSIA 970
Cdd:COG0666  149 Q-DNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA-DVNAKDNDGKTALDLA 226

                        170
                 ....*....|....*...
gi 156104862 971 LKSPtHMEIAGLLRAHAE 988
Cdd:COG0666  227 AENG-NLEIVKLLLEAGA 243
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
817-988 3.62e-29

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 118.52  E-value: 3.62e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156104862 817 VNLADHNGNTALHYSVSHSNFSIVKLLLETGVcNVDHQNKAGYTavmitPLASAETNEDMAVVWKLLREG-NVNIQaTQG 895
Cdd:COG0666  113 VNARDKDGETPLHLAAYNGNLEIVKLLLEAGA-DVNAQDNDGNT-----PLHLAAANGNLEIVKLLLEAGaDVNAR-DND 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156104862 896 GQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPAcDSSLTDKAGRTALSIALKSPT 975
Cdd:COG0666  186 GETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGA-DLNAKDKDGLTALLLAAAAGA 264

                        170
                 ....*....|...
gi 156104862 976 HMEIAGLLRAHAE 988
Cdd:COG0666  265 ALIVKLLLLALLL 277
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
812-986 5.36e-27

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 111.97  E-value: 5.36e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156104862 812 FLKLLVNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTavmitPLASAETNEDMAVVWKLLREG-NVNI 890
Cdd:COG0666   41 LLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNT-----LLHAAARNGDLEIVKLLLEAGaDVNA 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156104862 891 QaTQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPAcDSSLTDKAGRTALSIA 970
Cdd:COG0666  116 R-DKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGA-DVNARDNDGETPLHLA 193

                        170
                 ....*....|....*.
gi 156104862 971 LKSPtHMEIAGLLRAH 986
Cdd:COG0666  194 AENG-HLEIVKLLLEA 208
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
812-986 7.64e-21

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 93.87  E-value: 7.64e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156104862 812 FLKLLVNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVWKLLREGNVNIQ 891
Cdd:COG0666    3 LLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156104862 892 ATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPAcDSSLTDKAGRTALSIAL 971
Cdd:COG0666   83 KDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGA-DVNAQDNDGNTPLHLAA 161

                        170
                 ....*....|....*
gi 156104862 972 KSPtHMEIAGLLRAH 986
Cdd:COG0666  162 ANG-NLEIVKLLLEA 175
KN_motif pfam12075
KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the ...
 24-62 2.74e-20

KN motif; This small motif is found at the N-terminus of Kank proteins and has been called the KN (for Kank N-terminal) motif. This protein is found in eukaryotes. Proteins in this family are typically between 413 to 1202 amino acids in length. This protein is found associated with pfam00023. This protein has two conserved sequence motifs: TPYG and LDLDF. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors.


Pssm-ID: 432311  Cd Length: 39  Bit Score: 84.71  E-value: 2.74e-20
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 156104862   24 PYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRAK 62
Cdd:pfam12075   1 PYSVETPYGFHLDLDFLKYVEDIESGQTIRRARVQRRPR 39
Ank_2 pfam12796
Ankyrin repeats (3 copies);
900-986 1.06e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 73.23  E-value: 1.06e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156104862  900 LMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPACDSsltDKAGRTALSIALKSpTHMEI 979
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL---KDNGRTALHYAARS-GHLEI 76


                  ....*..
gi 156104862  980 AGLLRAH 986
Cdd:pfam12796  77 VKLLLEK 83
Ank_2 pfam12796
Ankyrin repeats (3 copies);
828-926 1.40e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 70.14  E-value: 1.40e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156104862  828 LHYSVSHSNFSIVKLLLETGvCNVDHQNKAGYTAVMItplasAETNEDMAVVWKLLREGNVNIQAtqGGQTALMLGVSHD 907
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENG-ADANLQDKNGRTALHL-----AAKNGHLEIVKLLLEHADVNLKD--NGRTALHYAARSG 72

                          90
                  ....*....|....*....
gi 156104862  908 REDMVQALLSCQADVNLQD 926
Cdd:pfam12796  73 HLEIVKLLLEKGADINVKD 91
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 817-987 7.32e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 71.92  E-value: 7.32e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156104862 817 VNLADHNGNTALHYSVSHSNFSIVKLLLETGV-CNVDHQNKAgytavmiTPLASAETNEDMAVVWKLLREGNVNIQATQG 895
Cdd:PHA02874 150 VNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAyANVKDNNGE-------SPLHNAAEYGDYACIKLLIDHGNHIMNKCKN 222

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156104862 896 GQTALMLGVSHDREdmVQALLSCQADVNLQDHDGSSALmvacHHG-----NVDLVRLLLAHPAcDSSLTDKAGRTALSIA 970
Cdd:PHA02874 223 GFTPLHNAIIHNRS--AIELLINNASINDQDIDGSTPL----HHAinppcDIDIIDILLYHKA-DISIKDNKGENPIDTA 295

                        170
                 ....*....|....*..
gi 156104862 971 LKSPTHMEIAGLLRAHA 987
Cdd:PHA02874 296 FKYINKDPVIKDIIANA 312
Ank_2 pfam12796
Ankyrin repeats (3 copies);
873-953 5.12e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 62.83  E-value: 5.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156104862  873 NEDMAVVWKLLREG-NVNIQaTQGGQTALMLGVSHDREDMVQALLScQADVNLQDHdGSSALMVACHHGNVDLVRLLLAH 951
Cdd:pfam12796   7 NGNLELVKLLLENGaDANLQ-DKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIVKLLLEK 83


                  ..
gi 156104862  952 PA 953
Cdd:pfam12796  84 GA 85
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 817-954 4.56e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 59.89  E-value: 4.56e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156104862 817 VNLADHNGNTALHYSVSHSNFSIVKLLLETGvCNVDHQNKAGYTAVMItplaSAETNEDMAVVWKLLREG-NVNIQATQG 895
Cdd:PHA02878 194 VNIPDKTNNSPLHHAVKHYNKPIVHILLENG-ASTDARDKCGNTPLHI----SVGYCKDYDILKLLLEHGvDVNAKSYIL 268

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 156104862 896 GQTALMLGVsHDrEDMVQALLSCQADVNLQDHDGSSAL-MVACHHGNVDLVRLLLAHPAC 954
Cdd:PHA02878 269 GLTALHSSI-KS-ERKLKLLLEYGADINSLNSYKLTPLsSAVKQYLCINIGRILISNICL 326
Ank_5 pfam13857
Ankyrin repeats (many copies);
915-970 5.33e-09

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 53.12  E-value: 5.33e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 156104862  915 LLSC-QADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPaCDSSLTDKAGRTALSIA 970
Cdd:pfam13857   1 LLEHgPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYG-VDLNLKDEEGLTALDLA 56
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 772-951 1.97e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 57.75  E-value: 1.97e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156104862 772 LLRQSLNTisqewfRVSSRKSSSPAVVASYLHEVQPHSPHFLKLL------VNLADHNGNTALHYSVSHS--NFSIVKLL 843
Cdd:PHA03100  54 LLDNGADI------NSSTKNNSTPLHYLSNIKYNLTDVKEIVKLLleyganVNAPDNNGITPLLYAISKKsnSYSIVEYL 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156104862 844 LETGvCNVDHQNKAGYTAVMITpLASAETNEDMAvvwKLLREGNVNIQA--------TQG---------GQTALMLGVSH 906
Cdd:PHA03100 128 LDNG-ANVNIKNSDGENLLHLY-LESNKIDLKIL---KLLIDKGVDINAknrvnyllSYGvpinikdvyGFTPLHYAVYN 202

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 156104862 907 DREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAH 951
Cdd:PHA03100 203 NNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNN 247
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 912-994 3.98e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 57.22  E-value: 3.98e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156104862 912 VQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPAcDSSLTDKAGRTALSIALKSPTHmEIAGLLRAHAEQGR 991
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGA-DPTLLDKDGKTPLELAEENGFR-EVVQLLSRHSQCHF 175


                 ...
gi 156104862 992 SLG 994
Cdd:PTZ00322 176 ELG 178
Ank_4 pfam13637
Ankyrin repeats (many copies);
898-949 1.47e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.81  E-value: 1.47e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 156104862  898 TALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLL 949
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 814-953 3.69e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 51.02  E-value: 3.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156104862 814 KLLVNLADHNGNTALHYSVSHSNFSIVKLLLETGvCNVDHQNKAGYTAvMITPLASAEtNEDMAVVWKLLREGNvniqaT 893
Cdd:PLN03192 548 KLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHA-CNVHIRDANGNTA-LWNAISAKH-HKIFRILYHFASISD-----P 619

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 156104862 894 QGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPA 953
Cdd:PLN03192 620 HAAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGA 679
PHA03095 PHA03095
ankyrin-like protein; Provisional
 873-983 4.30e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 50.41  E-value: 4.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156104862 873 NEDMAVVWKLLREG-NVNiQATQGGQTAL---MLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNV-DLVRL 947
Cdd:PHA03095  24 NVTVEEVRRLLAAGaDVN-FRGEYGKTPLhlyLHYSSEKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTlDVIKL 102

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 156104862 948 LLAHPAcDSSLTDKAGRTALSIALKSP-THMEIAGLL 983
Cdd:PHA03095 103 LIKAGA-DVNAKDKVGRTPLHVYLSGFnINPKVIRLL 138
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 812-892 1.57e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 48.51  E-value: 1.57e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156104862 812 FLKLLV--NLADHNGNTALHYSVSHSNFSIVKLLLETGvCNVDHQNKAGYtavmiTPLASAETNEDMAVVwKLLREGNVN 889
Cdd:PHA03100 178 LLSYGVpiNIKDVYGFTPLHYAVYNNNPEFVKYLLDLG-ANPNLVNKYGD-----TPLHIAILNNNKEIF-KLLLNNGPS 250


                 ...
gi 156104862 890 IQA 892
Cdd:PHA03100 251 IKT 253
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 818-971 1.61e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 48.45  E-value: 1.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156104862 818 NLADHNGNTALHYSVSHSNFSIVKLLLETG-VCNVDHQNkagytavMITPLASAETNEDMAVVWKLLREGN-VNIQATQG 895
Cdd:PHA02875  29 NFEIYDGISPIKLAMKFRDSEAIKLLMKHGaIPDVKYPD-------IESELHDAVEEGDVKAVEELLDLGKfADDVFYKD 101

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 156104862 896 GQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPACdSSLTDKAGRTALSIAL 971
Cdd:PHA02875 102 GMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKAC-LDIEDCCGCTPLIIAM 176
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 828-987 1.62e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 48.51  E-value: 1.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156104862 828 LHYSVSHSNFSIVKLLLETGvCNVDHQNKAGYTAVMITPLASAETNEDMAVVWKLLREG--------------------- 886
Cdd:PHA03100  39 LYLAKEARNIDVVKILLDNG-ADINSSTKNNSTPLHYLSNIKYNLTDVKEIVKLLLEYGanvnapdnngitpllyaiskk 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156104862 887 ---------------NVNIQaTQGGQTALML------------------GVSHDREDMVQALLSCQADVNLQDHDGSSAL 933
Cdd:PHA03100 118 snsysiveylldngaNVNIK-NSDGENLLHLylesnkidlkilkllidkGVDINAKNRVNYLLSYGVPINIKDVYGFTPL 196

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 156104862 934 MVACHHGNVDLVRLLLaHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRAHA 987
Cdd:PHA03100 197 HYAVYNNNPEFVKYLL-DLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGP 249
Ank_4 pfam13637
Ankyrin repeats (many copies);
929-983 4.68e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.88  E-value: 4.68e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 156104862  929 GSSALMVACHHGNVDLVRLLLAHPAcDSSLTDKAGRTALSIALKSpTHMEIAGLL 983
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGA-DINAVDGNGETALHFAASN-GNVEVLKLL 53
PHA03095 PHA03095
ankyrin-like protein; Provisional
 817-974 7.52e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 46.56  E-value: 7.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156104862 817 VNLADHNGNTALHYSVSHSN-FSIVKLLLETGVcNVDHQNKAGYTAVMITpLASAETNEDmaVVWKLLREGnvniqatqg 895
Cdd:PHA03095  76 VNAPERCGFTPLHLYLYNATtLDVIKLLIKAGA-DVNAKDKVGRTPLHVY-LSGFNINPK--VIRLLLRKG--------- 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156104862 896 gqtalmlgvshdredmvqallscqADVNLQDHDGSSAL--MVACHHGNVDLVRLLLAHpACDSSLTDKAGRTALSIALKS 973
Cdd:PHA03095 143 ------------------------ADVNALDLYGMTPLavLLKSRNANVELLRLLIDA-GADVYAVDDRFRSLLHHHLQS 197


                 .
gi 156104862 974 P 974
Cdd:PHA03095 198 F 198
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 823-856 9.47e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 40.35  E-value: 9.47e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 156104862  823 NGNTALHYSVSHS-NFSIVKLLLETGvCNVDHQNK 856
Cdd:pfam00023   1 DGNTPLHLAAGRRgNLEIVKLLLSKG-ADVNARDK 34
Ank_5 pfam13857
Ankyrin repeats (many copies);
882-936 1.32e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 40.79  E-value: 1.32e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 156104862  882 LLREGNVNIQATQG-GQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVA 936
Cdd:pfam13857   1 LLEHGPIDLNRLDGeGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 790-924 2.04e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 44.98  E-value: 2.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156104862 790 RKSSSPAVVASYLHEVQphsphFLKLLV------NLADHNGNTALHYSVSHSNFSIVKLLLETGVCnVDHQNKAGYTavm 863
Cdd:PHA02875 100 KDGMTPLHLATILKKLD-----IMKLLIargadpDIPNTDKFSPLHLAVMMGDIKGIELLIDHKAC-LDIEDCCGCT--- 170

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 156104862 864 itPLASAETNEDMAVVWKLLREG-NVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNL 924
Cdd:PHA02875 171 --PLIIAMAKGDIAICKMLLDSGaNIDYFGKNGCVAALCYAIENNKIDIVRLFIKRGADCNI 230
Ank_4 pfam13637
Ankyrin repeats (many copies);
824-877 2.39e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.95  E-value: 2.39e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 156104862  824 GNTALHYSVSHSNFSIVKLLLETGVcNVDHQNKAGYTAVMItplASAETNEDMA 877
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGA-DINAVDGNGETALHF---AASNGNVEVL 50
Ank_4 pfam13637
Ankyrin repeats (many copies);
817-844 2.91e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.57  E-value: 2.91e-04
                          10        20
                  ....*....|....*....|....*...
gi 156104862  817 VNLADHNGNTALHYSVSHSNFSIVKLLL 844
Cdd:pfam13637  27 INAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 817-986 3.12e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 44.49  E-value: 3.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156104862 817 VNLADHNGNTALHYSVSHSN-FSIVKLLLETGVCNVDHQNKAGYTA-----------VMITPLASAETNEDM-------- 876
Cdd:PHA02878  63 VNQPDHRDLTPLHIICKEPNkLGMKEMIRSINKCSVFYTLVAIKDAfnnrnveifkiILTNRYKNIQTIDLVyidkkskd 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156104862 877 ----AVVWKLLRE--GNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLA 950
Cdd:PHA02878 143 diieAEITKLLLSygADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLE 222

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 156104862 951 HPAcDSSLTDKAGRTALSIALKSPTHMEIAGLLRAH 986
Cdd:PHA02878 223 NGA-STDARDKCGNTPLHISVGYCKDYDILKLLLEH 257
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
341-411 3.88e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 44.12  E-value: 3.88e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 156104862 341 SISSLKQQVSALEGELSGRTEELAQVRTALQQQEEEIKAREQRIREL--EFTVAQLEGQFHQENAKDTQGQTD 411
Cdd:COG4372   39 ELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELneQLQAAQAELAQAQEELESLQEEAE 111
ATG16 pfam08614
Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for ...
 335-395 4.74e-04

Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for eukaryotic cells. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. ATG16 (also known as Apg16) has been shown to be bind to Apg5 and is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway.


Pssm-ID: 462536 [Multi-domain]  Cd Length: 176  Bit Score: 42.23  E-value: 4.74e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 156104862  335 ARVDPGSISSLKQQVSALEGELSG----RTEELAQVRTA---LQQQEEEIKAREQRIRELEFTVAQLE 395
Cdd:pfam08614  45 ASPQSASIQSLEQLLAQLREELAElyrsRGELAQRLVDLneeLQELEKKLREDERRLAALEAERAQLE 112
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 817-971 5.34e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 43.90  E-value: 5.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156104862 817 VNLADHNGNTALHYSVSHSNFS-IVKLLLETGVcNVDHQNKAGYTAVMITplasAETNEDMAVVWKLLREGnVNIQATQG 895
Cdd:PHA02876 266 VNSIDDCKNTPLHHASQAPSLSrLVPKLLERGA-DVNAKNIKGETPLYLM----AKNGYDTENIRTLIMLG-ADVNAADR 339

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 156104862 896 -GQTALMLGVSHDR-EDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPACDSSLTDKAGrTALSIAL 971
Cdd:PHA02876 340 lYITPLHQASTLDRnKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIG-TALHFAL 416
PHA03095 PHA03095
ankyrin-like protein; Provisional
 813-950 1.01e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 42.70  E-value: 1.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156104862 813 LKLLVNL------ADHNGNTALHY--SVSHSNFSIVKLLLETGvCNVDHQNKAGYTavmitPLASAETNEDMA--VVWKL 882
Cdd:PHA03095 170 LRLLIDAgadvyaVDDRFRSLLHHhlQSFKPRARIVRELIRAG-CDPAATDMLGNT-----PLHSMATGSSCKrsLVLPL 243

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 156104862 883 LrEGNVNIQAT-QGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLA 950
Cdd:PHA03095 244 L-IAGISINARnRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALA 311
ZapB pfam06005
Cell division protein ZapB; ZapB is a non-essential, abundant cell division factor that is ...
 342-387 1.11e-03

Cell division protein ZapB; ZapB is a non-essential, abundant cell division factor that is required for proper Z-ring formation.


Pssm-ID: 428718 [Multi-domain]  Cd Length: 71  Bit Score: 38.40  E-value: 1.11e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 156104862  342 ISSLKQQVSALEGELSGRTEELAQVRTALQQQEEEIKAREQRIREL 387
Cdd:pfam06005  20 IALLQMENEELKEENEELKEEANELEEENQQLKQERNQWQERIRGL 65
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 896-958 1.29e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.58  E-value: 1.29e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 156104862 896 GQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPACDSSL 958
Cdd:PTZ00322 115 GRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFEL 177
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 823-848 1.65e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 1.65e-03
                           10        20
                   ....*....|....*....|....*.
gi 156104862   823 NGNTALHYSVSHSNFSIVKLLLETGV 848
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGA 26
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
342-412 1.67e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 41.81  E-value: 1.67e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 156104862 342 ISSLKQQVSALEGELSGRTEELAQVRTALQQQEEEIKAREQRIRELEFTVAQLEGQFHQENAKDTQGQTDV 412
Cdd:COG4372   47 LEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEEL 117
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 342-405 1.77e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 41.06  E-value: 1.77e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 156104862 342 ISSLKQQVSALEGELSGRTEELAQVRTALQQQEEEIKAREQRIRELEFTVAQLEGQfhQENAKD 405
Cdd:COG1579   26 LKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQ--LGNVRN 87
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 896-927 1.86e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.88  E-value: 1.86e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 156104862  896 GQTALMLGVSH-DREDMVQALLSCQADVNLQDH 927
Cdd:pfam00023   2 GNTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 928-951 2.51e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 2.51e-03
                           10        20
                   ....*....|....*....|....
gi 156104862   928 DGSSALMVACHHGNVDLVRLLLAH 951
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDK 24
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 928-953 2.52e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.08  E-value: 2.52e-03
                          10        20
                  ....*....|....*....|....*.
gi 156104862  928 DGSSALMVACHHGNVDLVRLLLAHPA 953
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGA 26
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
342-414 3.14e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 41.04  E-value: 3.14e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 156104862 342 ISSLKQQVSALEGELSGRTEELAQVRTALQQQEEEIKAREQRIRELEFTVAQLEGQFHQENAKDTQGQTDVMV 414
Cdd:COG4372  117 LEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQALDELL 189
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 342-400 3.15e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.90  E-value: 3.15e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 156104862 342 ISSLKQQVSALEGELSGRTEELAQVRTALQQQEEEIKAREQRIRELEFTVAQLEGQFHQ 400
Cdd:COG4942   43 LAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEA 101
Ank_5 pfam13857
Ankyrin repeats (many copies);
815-862 3.70e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.56  E-value: 3.70e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 156104862  815 LLVNLADHNGNTALHYSVSHSNFSIVKLLLETGV-CNVdhQNKAGYTAV 862
Cdd:pfam13857   7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVdLNL--KDEEGLTAL 53
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 342-397 4.70e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.52  E-value: 4.70e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 156104862 342 ISSLKQQVSALEGELSGRTEELAQVRTALQQQEEEIKAREQRIRELEFTVAQLEGQ 397
Cdd:COG4942   29 LEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAE 84
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 317-388 5.26e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 39.52  E-value: 5.26e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 156104862 317 EVDMRSIGIRVTEESLglarvdPGSISSLKQQVSALEGELSGRTEELAQVRTALQQQEEEIKAREQRIRELE 388
Cdd:COG1579   14 ELDSELDRLEHRLKEL------PAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYE 79
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 896-923 5.31e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 35.31  E-value: 5.31e-03
                          10        20
                  ....*....|....*....|....*...
gi 156104862  896 GQTALMLGVSHDREDMVQALLSCQADVN 923
Cdd:pfam13606   2 GNTPLHLAARNGRLEIVKLLLENGADIN 29
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
341-409 6.46e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 39.89  E-value: 6.46e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 156104862 341 SISSLKQQVSALEGELSGRTEELAQVRTALQQQEEEIKAREQRIRELEFTVAQLEGQFHQENAKDTQGQ 409
Cdd:COG4372   32 QLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQ 100
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
317-409 6.90e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 40.28  E-value: 6.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156104862  317 EVDMRSI--GIRVTEESLGLARVDPGSISSLKQQVSALEGELSGRTEELAQVRTALQQQEEEIKAREQRIRELE------ 388
Cdd:COG4913   660 EIDVASAerEIAELEAELERLDASSDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQdrleaa 739

                          90       100
                  ....*....|....*....|....*..
gi 156104862  389 ------FTVAQLEGQFHQENAKDTQGQ 409
Cdd:COG4913   740 edlarlELRALLEERFAAALGDAVERE 766
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 823-848 7.21e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 34.93  E-value: 7.21e-03
                          10        20
                  ....*....|....*....|....*.
gi 156104862  823 NGNTALHYSVSHSNFSIVKLLLETGV 848
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGA 26
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
342-397 7.81e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 39.89  E-value: 7.81e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 156104862 342 ISSLKQQVSALEGELSGRTEELAQVRTALQQQEEEIKAREQRIRELEFTVAQLEGQ 397
Cdd:COG4372   68 LEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKE 123
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
 325-388 8.65e-03

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 40.01  E-value: 8.65e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 156104862  325 IRVTEESLGLARVDPgsISSLKQQVSALEGELSGRTEELAQVRTALQQQEEEIKAREQRIRELE 388
Cdd:pfam05667 322 KVETEEELQQQREEE--LEELQEQLEDLESSIQELEKEIKKLESSIKQVEEELEELKEQNEELE 383
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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