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Conserved domains on  [gi|15609255|ref|NP_216634|]
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tRNA (adenine(58)-N(1))-methyltransferase [Mycobacterium tuberculosis H37Rv]

Protein Classification

tRNA (adenine-N1)-methyltransferase( domain architecture ID 11457537)

tRNA (adenine-N1)-methyltransferase, such as tRNA (adenine(58)-N(1))-methyltransferase, which is a class I SAM-dependent methyltransferase that catalyzes the methylation of N(1)-adenine at position 58 (m1A58) in tRNA using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 10-261 6.87e-143

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


:

Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 401.46  E-value: 6.87e-143
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609255  10 GERVQLTDAKGRRYTMSLTPGAEFHTHRGSIAHDAVIGLEQGSVVKSSNGALFLVLRPLLVDYVMSMPRGPQVIYPKDAA 89
Cdd:COG2519   2 GDRVLLTDPKGRKYLVRLEEGKKFHTHKGIIDHDDLIGKPEGSVVTTSKGKEFLVLRPTLYDYVLSMKRGTQIIYPKDAG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609255  90 QIVHEGDIFPGARVLEAGAGSGALTLSLLRAVGPAGQVISYEQRADHAEHARRNVSGCYgqPPDNWRLVVSDLADsELPD 169
Cdd:COG2519  82 YIIARLDIFPGARVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAEIARKNLERFG--LPDNVELKLGDIRE-GIDE 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609255 170 GSVDRAVLDMLAPWEVLDAVSRLLVAGGVLMVYVATVTQLSRIVEALRAKQcWTEPRAWETLQRGWNVVGLAVRPQHSMR 249
Cdd:COG2519 159 GDVDAVFLDMPDPWEALEAVAKALKPGGVLVAYVPTVNQVSKLVEALRESG-FTDIEAVETLLREWKVEGLAVRPEHRMV 237

                       250
                ....*....|..
gi 15609255 250 GHTAFLVATRRL 261
Cdd:COG2519 238 GHTGFLVFARKL 249
 
Name Accession Description Interval E-value
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 10-261 6.87e-143

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 401.46  E-value: 6.87e-143
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609255  10 GERVQLTDAKGRRYTMSLTPGAEFHTHRGSIAHDAVIGLEQGSVVKSSNGALFLVLRPLLVDYVMSMPRGPQVIYPKDAA 89
Cdd:COG2519   2 GDRVLLTDPKGRKYLVRLEEGKKFHTHKGIIDHDDLIGKPEGSVVTTSKGKEFLVLRPTLYDYVLSMKRGTQIIYPKDAG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609255  90 QIVHEGDIFPGARVLEAGAGSGALTLSLLRAVGPAGQVISYEQRADHAEHARRNVSGCYgqPPDNWRLVVSDLADsELPD 169
Cdd:COG2519  82 YIIARLDIFPGARVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAEIARKNLERFG--LPDNVELKLGDIRE-GIDE 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609255 170 GSVDRAVLDMLAPWEVLDAVSRLLVAGGVLMVYVATVTQLSRIVEALRAKQcWTEPRAWETLQRGWNVVGLAVRPQHSMR 249
Cdd:COG2519 159 GDVDAVFLDMPDPWEALEAVAKALKPGGVLVAYVPTVNQVSKLVEALRESG-FTDIEAVETLLREWKVEGLAVRPEHRMV 237

                       250
                ....*....|..
gi 15609255 250 GHTAFLVATRRL 261
Cdd:COG2519 238 GHTGFLVFARKL 249
GCD14_N pfam14801
tRNA methyltransferase complex GCD14 subunit N-term; This is the N-terminal domain of GCD14, ...
 4-54 3.06e-27

tRNA methyltransferase complex GCD14 subunit N-term; This is the N-terminal domain of GCD14, itself a subunit of the tRNA methyltransferase complex that is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA. The exact function of the N-terminus is not known but it is necessary for maintaining the overall folding and for full enzymatic activity.


Pssm-ID: 434222  Cd Length: 51  Bit Score: 99.88  E-value: 3.06e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 15609255     4 TGPFSIGERVQLTDAKGRRYTMSLTPGAEFHTHRGSIAHDAVIGLEQGSVV 54
Cdd:pfam14801   1 RGPFRAGDRVQLTDPKGRKHTITLEPGGEFHTHRGAIRHDDLIGRPEGSVV 51
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 102-201 9.88e-13

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 63.22  E-value: 9.88e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609255 102 RVLEAGAGSGALTLSLLRavGPAGQVISYEQRADHAEHARRNVsgcYGQPPDNWRLVVSDLAD-SELPDGSVDRAVLD-- 178
Cdd:cd02440   1 RVLDLGCGTGALALALAS--GPGARVTGVDISPVALELARKAA---AALLADNVEVLKGDAEElPPEADESFDVIISDpp 75

                        90       100
                ....*....|....*....|....*..
gi 15609255 179 ----MLAPWEVLDAVSRLLVAGGVLMV 201
Cdd:cd02440  76 lhhlVEDLARFLEEARRLLKPGGVLVL 102
PRK08317 PRK08317
hypothetical protein; Provisional
 96-197 6.78e-06

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 46.08  E-value: 6.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609255   96 DIFPGARVLEAGAGSGALTLSLLRAVGPAGQVISYEQRADHAEHAR-RNVSGCygqppDNWRLVVSDLADSELPDGSVDR 174
Cdd:PRK08317  16 AVQPGDRVLDVGCGPGNDARELARRVGPEGRVVGIDRSEAMLALAKeRAAGLG-----PNVEFVRGDADGLPFPDGSFDA 90

                         90       100
                 ....*....|....*....|....*...
gi 15609255  175 AVLD-----MLAPWEVLDAVSRLLVAGG 197
Cdd:PRK08317  91 VRSDrvlqhLEDPARALAEIARVLRPGG 118
rADc smart00650
Ribosomal RNA adenine dimethylases;
88-176 6.92e-05

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 42.50  E-value: 6.92e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609255     88 AAQIVHEGDIFPGARVLEAGAGSGALTLSLLRAvgpAGQVISYEQRADHAEHARRNVsgcygQPPDNWRLVVSDLADSEL 167
Cdd:smart00650   2 IDKIVRAANLRPGDTVLEIGPGKGALTEELLER---AKRVTAIEIDPRLAPRLREKF-----AAADNLTVIHGDALKFDL 73


                   ....*....
gi 15609255    168 PDGSVDRAV 176
Cdd:smart00650  74 PKLQPYKVV 82
 
Name Accession Description Interval E-value
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 10-261 6.87e-143

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 401.46  E-value: 6.87e-143
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609255  10 GERVQLTDAKGRRYTMSLTPGAEFHTHRGSIAHDAVIGLEQGSVVKSSNGALFLVLRPLLVDYVMSMPRGPQVIYPKDAA 89
Cdd:COG2519   2 GDRVLLTDPKGRKYLVRLEEGKKFHTHKGIIDHDDLIGKPEGSVVTTSKGKEFLVLRPTLYDYVLSMKRGTQIIYPKDAG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609255  90 QIVHEGDIFPGARVLEAGAGSGALTLSLLRAVGPAGQVISYEQRADHAEHARRNVSGCYgqPPDNWRLVVSDLADsELPD 169
Cdd:COG2519  82 YIIARLDIFPGARVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAEIARKNLERFG--LPDNVELKLGDIRE-GIDE 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609255 170 GSVDRAVLDMLAPWEVLDAVSRLLVAGGVLMVYVATVTQLSRIVEALRAKQcWTEPRAWETLQRGWNVVGLAVRPQHSMR 249
Cdd:COG2519 159 GDVDAVFLDMPDPWEALEAVAKALKPGGVLVAYVPTVNQVSKLVEALRESG-FTDIEAVETLLREWKVEGLAVRPEHRMV 237

                       250
                ....*....|..
gi 15609255 250 GHTAFLVATRRL 261
Cdd:COG2519 238 GHTGFLVFARKL 249
GCD14_N pfam14801
tRNA methyltransferase complex GCD14 subunit N-term; This is the N-terminal domain of GCD14, ...
 4-54 3.06e-27

tRNA methyltransferase complex GCD14 subunit N-term; This is the N-terminal domain of GCD14, itself a subunit of the tRNA methyltransferase complex that is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA. The exact function of the N-terminus is not known but it is necessary for maintaining the overall folding and for full enzymatic activity.


Pssm-ID: 434222  Cd Length: 51  Bit Score: 99.88  E-value: 3.06e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 15609255     4 TGPFSIGERVQLTDAKGRRYTMSLTPGAEFHTHRGSIAHDAVIGLEQGSVV 54
Cdd:pfam14801   1 RGPFRAGDRVQLTDPKGRKHTITLEPGGEFHTHRGAIRHDDLIGRPEGSVV 51
GCD14 pfam08704
tRNA methyltransferase complex GCD14 subunit; GCD14 is a subunit of the tRNA methyltransferase ...
 64-237 4.44e-21

tRNA methyltransferase complex GCD14 subunit; GCD14 is a subunit of the tRNA methyltransferase complex and is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA.


Pssm-ID: 312288  Cd Length: 242  Bit Score: 89.09  E-value: 4.44e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609255    64 VLRPLLVDYVMSMPRGPQVIYPKDAAQIVHEGDIFPGARVLEAGAGSGALTLSLLRAVGPAGQVISYE---QRADHA-EH 139
Cdd:pfam08704   5 VLQPTPELWTLNLPHRTQILYTPDISLITMMLELRPGSVVCESGTGSGSLSHAIIRTVAPTGHLFTFEfheQRADKArEE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609255   140 ARRNVSGcygqppDNWRLVVSDLADSELP---DGSVDRAVLDMLAPWE-VLDAVSRLLVAGGVLMVYVATVTQLSRIVEA 215
Cdd:pfam08704  85 FREHGID------QLVTVTHRDVCKEGFLtevSGKADAVFLDLPSPWEaVPHAWKALKVEGGRFCSFSPCIEQVQRTCQA 158

                         170       180
                  ....*....|....*....|..
gi 15609255   216 LRAKQcWTEPRAWETLQRGWNV 237
Cdd:pfam08704 159 LAELG-FTEISTLEVLLRVYDV 179
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 102-201 9.88e-13

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 63.22  E-value: 9.88e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609255 102 RVLEAGAGSGALTLSLLRavGPAGQVISYEQRADHAEHARRNVsgcYGQPPDNWRLVVSDLAD-SELPDGSVDRAVLD-- 178
Cdd:cd02440   1 RVLDLGCGTGALALALAS--GPGARVTGVDISPVALELARKAA---AALLADNVEVLKGDAEElPPEADESFDVIISDpp 75

                        90       100
                ....*....|....*....|....*..
gi 15609255 179 ----MLAPWEVLDAVSRLLVAGGVLMV 201
Cdd:cd02440  76 lhhlVEDLARFLEEARRLLKPGGVLVL 102
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 99-218 4.16e-10

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 56.93  E-value: 4.16e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609255  99 PGARVLEAGAGSGALTLSLLRAvgpAGQVISYEQRADHAEHARRNVSgcygQPPDNWRLVVSDLADSELPDGSVDRA--- 175
Cdd:COG2226  22 PGARVLDLGCGTGRLALALAER---GARVTGVDISPEMLELARERAA----EAGLNVEFVVGDAEDLPFPDGSFDLViss 94

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 15609255 176 -VLDMLA-PWEVLDAVSRLLVAGGVLMVYVATVTQLSRIVEALRA 218
Cdd:COG2226  95 fVLHHLPdPERALAEIARVLKPGGRLVVVDFSPPDLAELEELLAE 139
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 102-218 3.97e-09

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 54.81  E-value: 3.97e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609255 102 RVLEAGAGSGALTLSLLRAVGPAGQVISYEQRADHAEHARRNV--SGCygqpPDNWRLVVSDLAD--SELPDGSVDRAVL 177
Cdd:COG4122  19 RILEIGTGTGYSTLWLARALPDDGRLTTIEIDPERAAIARENFarAGL----ADRIRLILGDALEvlPRLADGPFDLVFI 94

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 15609255 178 D---MLAPwEVLDAVSRLLVAGGVLMV-------YVATVTQLSRIVEALRA 218
Cdd:COG4122  95 DadkSNYP-DYLELALPLLRPGGLIVAdnvlwhgRVADPARRDPSTRAIRE 144
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 99-201 3.58e-08

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 50.79  E-value: 3.58e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609255  99 PGARVLEAGAGSGALTLSLLRAvgpAGQVISYEQRADHAEHARRNVsgcygqPPDNWRLVVSDLADSELPDGSVDRAV-L 177
Cdd:COG2227  24 AGGRVLDVGCGTGRLALALARR---GADVTGVDISPEALEIARERA------AELNVDFVQGDLEDLPLEDGSFDLVIcS 94

                        90       100
                ....*....|....*....|....*...
gi 15609255 178 DMLA----PWEVLDAVSRLLVAGGVLMV 201
Cdd:COG2227  95 EVLEhlpdPAALLRELARLLKPGGLLLL 122
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 103-197 7.77e-08

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 49.10  E-value: 7.77e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609255   103 VLEAGAGSGALTLSLLRAVGpaGQVISYEQRADHAEHARRNvsgcYGQPPDNWRLVVSDLADSELPDGSVDRAV------ 176
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGG--ARVTGVDLSPEMLERARER----AAEAGLNVEFVQGDAEDLPFPDGSFDLVVssgvlh 74

                          90       100
                  ....*....|....*....|..
gi 15609255   177 -LDMLAPWEVLDAVSRLLVAGG 197
Cdd:pfam13649  75 hLPDPDLEAALREIARVLKPGG 96
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 99-201 6.44e-07

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 48.76  E-value: 6.44e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609255  99 PGARVLEAGAGSGALTLSLLRAVGpaGQVISYEQRADHAEHARRNVSgcyGQPPDNWRLVVSDLADS-ELPDGSVDRAVL 177
Cdd:COG0500  26 KGGRVLDLGCGTGRNLLALAARFG--GRVIGIDLSPEAIALARARAA---KAGLGNVEFLVADLAELdPLPAESFDLVVA 100

                        90       100       110
                ....*....|....*....|....*....|.
gi 15609255 178 DMLAPW-------EVLDAVSRLLVAGGVLMV 201
Cdd:COG0500 101 FGVLHHlppeereALLRELARALKPGGVLLL 131
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
99-203 1.27e-06

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 45.97  E-value: 1.27e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609255  99 PGARVLEAGAGSGALTLSLLRAVgPAGQVISYEQRADHAEHARRNVSGCygqppdnwRLVVSDLADSElPDGSVD----R 174
Cdd:COG4106   1 PPRRVLDLGCGTGRLTALLAERF-PGARVTGVDLSPEMLARARARLPNV--------RFVVADLRDLD-PPEPFDlvvsN 70

                        90       100       110
                ....*....|....*....|....*....|
gi 15609255 175 AVLD-MLAPWEVLDAVSRLLVAGGVLMVYV 203
Cdd:COG4106  71 AALHwLPDHAALLARLAAALAPGGVLAVQV 100
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
96-144 2.18e-06

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 47.36  E-value: 2.18e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 15609255    96 DIFPGARVLEAGAGSGALTLSLLRAVGPAGQVISYEQRADHAEHARRNV 144
Cdd:pfam01135  70 ELKPGMRVLEIGSGSGYLTACFARMVGEVGRVVSIEHIPELVEIARRNL 118
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 91-204 2.28e-06

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 46.46  E-value: 2.28e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609255  91 IVHEGDIFPGARVLEAGAGSGALTLSLLRAVGpaGQV----ISYEQradhAEHARRNVSGcyGQPPDNWRLVVSDLADSE 166
Cdd:COG2230  43 ILRKLGLKPGMRVLDIGCGWGGLALYLARRYG--VRVtgvtLSPEQ----LEYARERAAE--AGLADRVEVRLADYRDLP 114

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 15609255 167 lPDGSVDRAV-LDML-----APW-EVLDAVSRLLVAGGVLMVYVA 204
Cdd:COG2230 115 -ADGQFDAIVsIGMFehvgpENYpAYFAKVARLLKPGGRLLLHTP 158
PRK08317 PRK08317
hypothetical protein; Provisional
 96-197 6.78e-06

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 46.08  E-value: 6.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609255   96 DIFPGARVLEAGAGSGALTLSLLRAVGPAGQVISYEQRADHAEHAR-RNVSGCygqppDNWRLVVSDLADSELPDGSVDR 174
Cdd:PRK08317  16 AVQPGDRVLDVGCGPGNDARELARRVGPEGRVVGIDRSEAMLALAKeRAAGLG-----PNVEFVRGDADGLPFPDGSFDA 90

                         90       100
                 ....*....|....*....|....*...
gi 15609255  175 AVLD-----MLAPWEVLDAVSRLLVAGG 197
Cdd:PRK08317  91 VRSDrvlqhLEDPARALAEIARVLRPGG 118
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 104-199 1.26e-05

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 43.13  E-value: 1.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609255   104 LEAGAGSGALTLSLLRAVgPAGQVISYEQRADHAEHARRNVSGCYGQPPDNWRLVVSDLADSELP--DGSVDRAVLDMLA 181
Cdd:pfam08242   1 LEIGCGTGTLLRALLEAL-PGLEYTGLDISPAALEAARERLAALGLLNAVRVELFQLDLGELDPGsfDVVVASNVLHHLA 79

                          90
                  ....*....|....*....
gi 15609255   182 -PWEVLDAVSRLLVAGGVL 199
Cdd:pfam08242  80 dPRAVLRNIRRLLKPGGVL 98
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
97-262 1.86e-05

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 44.64  E-value: 1.86e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609255  97 IFPGARVLEAGAGSGALTLSLLRAvgPAGQVISYEQRADHAEHARRNVSGcYGQpPDNWRLVVSDLADSELPDgSVDRAV 176
Cdd:COG4076  33 VKPGDVVLDIGTGSGLLSMLAARA--GAKKVYAVEVNPDIAAVARRIIAA-NGL-SDRITVINADATDLDLPE-KADVII 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609255 177 LDMLAPW-------EVL-DAVSRLLVAGGVLMVYVATVTqlsriVEALRAKQCwtEPRAWETLQRGWNVVGLAVRPQHSM 248
Cdd:COG4076 108 SEMLDTAlldegqvPILnHARKRLLKPGGRIIPERITNA-----AQPVESPVD--AEGFEDWQFDGFDFRLFGFLLYAEP 180

                       170
                ....*....|....
gi 15609255 249 RGHTAFLVATRRLA 262
Cdd:COG4076 181 LLHLTRLVRTPLLL 194
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 96-220 3.41e-05

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 44.77  E-value: 3.41e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609255  96 DIFPGARVLEAGAGSGALTLSLLRAvGPAGQVISYEQRADHAEHARRNVS--GCygqppDNWRLVVSD----LADSELPD 169
Cdd:COG2242 244 ALRPGDVLWDIGAGSGSVSIEAARL-APGGRVYAIERDPERAALIRANARrfGV-----PNVEVVEGEapeaLADLPDPD 317

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15609255 170 -----GSVDRAvldmlapWEVLDAVSRLLVAGGVLMVYVATVTQLSRIVEALRAKQ 220
Cdd:COG2242 318 avfigGSGGNL-------PEILEACWARLRPGGRLVANAVTLETLALALEALAELG 366
rADc smart00650
Ribosomal RNA adenine dimethylases;
88-176 6.92e-05

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 42.50  E-value: 6.92e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609255     88 AAQIVHEGDIFPGARVLEAGAGSGALTLSLLRAvgpAGQVISYEQRADHAEHARRNVsgcygQPPDNWRLVVSDLADSEL 167
Cdd:smart00650   2 IDKIVRAANLRPGDTVLEIGPGKGALTEELLER---AKRVTAIEIDPRLAPRLREKF-----AAADNLTVIHGDALKFDL 73


                   ....*....
gi 15609255    168 PDGSVDRAV 176
Cdd:smart00650  74 PKLQPYKVV 82
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 97-224 8.13e-05

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 42.02  E-value: 8.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609255    97 IFPGARVLEAGAGSGALTLSLLRAVGPAGQVISYEQRADHAEHARRNvsgCYGQPPDNWRLVVSDLAD--SELPDGSVD- 173
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAEELGPNAEVVGIDISEEAIEKAREN---AQKLGFDNVEFEQGDIEElpELLEDDKFDv 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15609255   174 ----RAVLDMLAPWEVLDAVSRLLVAGGVLMV--------YVATVTQLSRIVEALRAKQCWTE 224
Cdd:pfam13847  78 visnCVLNHIPDPDKVLQEILRVLKPGGRLIIsdpdslaeLPAHVKEDSTYYAGCVGGAILKK 140
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 104-201 8.19e-05

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 40.73  E-value: 8.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609255   104 LEAGAGSGALTLSLLRAvgpAGQVISYEQRADHAEHARRNVsgcygqPPDNWRLVVSDLADSELPDGSVD----RAVLDM 179
Cdd:pfam08241   1 LDVGCGTGLLTELLARL---GARVTGVDISPEMLELAREKA------PREGLTFVVGDAEDLPFPDNSFDlvlsSEVLHH 71

                          90       100
                  ....*....|....*....|...
gi 15609255   180 LA-PWEVLDAVSRLLVAGGVLMV 201
Cdd:pfam08241  72 VEdPERALREIARVLKPGGILII 94
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 88-131 1.26e-04

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 42.42  E-value: 1.26e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 15609255  88 AAQIVHEGDIFPGARVLEAGAGSGALTLSLLRAvgpAGQVISYE 131
Cdd:COG0030  26 IRRIVDAAGITPGDTVLEIGPGLGALTRALLER---AARVTAVE 66
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 99-256 1.61e-04

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 42.05  E-value: 1.61e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609255  99 PGARVLEAGAGSGALTLsLLRAVGPAGQVISYEQRADHAEHARRNV--SGCYGQ----------PPDNWR-----LVVS- 160
Cdd:COG4123  37 KGGRVLDLGTGTGVIAL-MLAQRSPGARITGVEIQPEAAELARRNValNGLEDRitvihgdlkeFAAELPpgsfdLVVSn 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609255 161 -----DLADSELPDGSVDRAVLDMLAPWE-VLDAVSRLLVAGGVL-MVYVAtvTQLSRIVEALRakqcwteprawetlQR 233
Cdd:COG4123 116 ppyfkAGSGRKSPDEARAIARHEDALTLEdLIRAAARLLKPGGRFaLIHPA--ERLAEILAALR--------------KY 179

                       170       180
                ....*....|....*....|...
gi 15609255 234 GWNVVglAVRPQHSMRGHTAFLV 256
Cdd:COG4123 180 GLGPK--RLRPVHPRPGKPAKRV 200
PRK13942 PRK13942
protein-L-isoaspartate O-methyltransferase; Provisional
 96-208 4.39e-04

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 184409  Cd Length: 212  Bit Score: 40.39  E-value: 4.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609255   96 DIFPGARVLEAGAGSG---ALTLSLlraVGPAGQVISYEQRADHAEHARRNVSGC-YgqppDNWRLVVSDLADSELPDGS 171
Cdd:PRK13942  73 DLKEGMKVLEIGTGSGyhaAVVAEI---VGKSGKVVTIERIPELAEKAKKTLKKLgY----DNVEVIVGDGTLGYEENAP 145

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 15609255  172 VDRAVLDMLAPwEVLDAVSRLLVAGGVLMVYVATVTQ 208
Cdd:PRK13942 146 YDRIYVTAAGP-DIPKPLIEQLKDGGIMVIPVGSYSQ 181
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
78-200 2.45e-03

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 38.06  E-value: 2.45e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609255  78 RGPQVIypkdAAQIVHEGDIFPGARVLEAGAGSGALTLSLLRAvgpAGQVISYEQRADHAEHARRNvsGCYGqppdnwRL 157
Cdd:COG4976  29 EAPALL----AEELLARLPPGPFGRVLDLGCGTGLLGEALRPR---GYRLTGVDLSEEMLAKAREK--GVYD------RL 93

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 15609255 158 VVSDLADSELPDGSVDRA----VLDMLA-PWEVLDAVSRLLVAGGVLM 200
Cdd:COG4976  94 LVADLADLAEPDGRFDLIvaadVLTYLGdLAAVFAGVARALKPGGLFI 141
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
88-173 3.18e-03

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 37.96  E-value: 3.18e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609255  88 AAQIVHE----GDIfPGARVLEAGAGSGALTL-SLLRAvgpAGQVISYEQRADHAEHARRNVSGCygqpPDNWRLVVSDL 162
Cdd:COG2263  31 AAELLHLaylrGDI-EGKTVLDLGCGTGMLAIgAALLG---AKKVVGVDIDPEALEIARENAERL----GVRVDFIRADV 102

                        90
                ....*....|.
gi 15609255 163 ADSELpDGSVD 173
Cdd:COG2263 103 TRIPL-GGSVD 112
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 85-222 3.23e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 37.41  E-value: 3.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609255    85 PKDAAQIVHE--GDIFPGARVLEAGAGSGALtLSLLRAVGPagQVISYEQRADHAEHARRnvsgcygqppdNWRLVVSDL 162
Cdd:pfam13489   6 ERLLADLLLRllPKLPSPGRVLDFGCGTGIF-LRLLRAQGF--SVTGVDPSPIAIERALL-----------NVRFDQFDE 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15609255   163 ADSELPDGSVD----RAVLDMLAPW-EVLDAVSRLLVAGGVLMvyVATVTQLSRIVEALRAKQCW 222
Cdd:pfam13489  72 QEAAVPAGKFDvivaREVLEHVPDPpALLRQIAALLKPGGLLL--LSTPLASDEADRLLLEWPYL 134
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 96-199 4.85e-03

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 37.38  E-value: 4.85e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609255  96 DIFPGARVLEAGAGSG---ALtLSLLravgpAGQVISYEQRADHAEHARRNVS--GCygqppDNWRLVVSDLADSELPDG 170
Cdd:COG2518  63 DLKPGDRVLEIGTGSGyqaAV-LARL-----AGRVYSVERDPELAERARERLAalGY-----DNVTVRVGDGALGWPEHA 131

                        90       100
                ....*....|....*....|....*....
gi 15609255 171 SVDRAVLDMlAPWEVLDAVSRLLVAGGVL 199
Cdd:COG2518 132 PFDRIIVTA-AAPEVPEALLEQLAPGGRL 159
RrnaAD pfam00398
Ribosomal RNA adenine dimethylase;
85-146 9.95e-03

Ribosomal RNA adenine dimethylase;


Pssm-ID: 395321 [Multi-domain]  Cd Length: 263  Bit Score: 36.57  E-value: 9.95e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15609255    85 PKDAAQIVHEGDIFPGARVLEAGAGSGALTLSLLRAvgpAGQVISYEQRADHAEHARRNVSG 146
Cdd:pfam00398  16 PKVINEIVDKANLRESDTVLEIGPGKGALTVILAKR---AKQVVAIEIDPRLAKLLQKKLSL 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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