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Conserved domains on  [gi|15609168|ref|NP_216547|]
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alpha-crystallin [Mycobacterium tuberculosis H37Rv]

Protein Classification

HSP20 family small heat-shock protein( domain architecture ID 10439842)

HSP20 family small heat-shock protein (sHsp) such as tomato chloroplast small heat shock protein HSP21 which is protecting photosystem II from oxidative stress and promoting color changes during fruit maturation.

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HSP20 pfam00011
Hsp20/alpha crystallin family; Not only do small heat-shock-proteins occur in eukaryotes and ...
 43-141 2.35e-30

Hsp20/alpha crystallin family; Not only do small heat-shock-proteins occur in eukaryotes and prokaryotes but they have also now been shown to occur in cyanobacterial phages as well as their bacterial hosts.


:

Pssm-ID: 459629  Cd Length: 100  Bit Score: 105.00  E-value: 2.35e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609168    43 EDEMKEGRYEVRAELPGVDPDkDVDIMVRDGQLTIKAERTEQK--DFDGRSEFAYGSFVRTVSLPVGADEDDIKATYDKG 120
Cdd:pfam00011   1 DIKEDEDAFEVRLDVPGFKPE-ELKVKVEDNRLLVKGEHEEEKedDHGLRSERSYGSFSRKFTLPENADPDKVKASLKDG 79

                          90       100
                  ....*....|....*....|.
gi 15609168   121 ILTVSVAVSEGKPTEKHIQIR 141
Cdd:pfam00011  80 VLTVTVPKLEPEPKERRIQIQ 100
 
Name Accession Description Interval E-value
HSP20 pfam00011
Hsp20/alpha crystallin family; Not only do small heat-shock-proteins occur in eukaryotes and ...
 43-141 2.35e-30

Hsp20/alpha crystallin family; Not only do small heat-shock-proteins occur in eukaryotes and prokaryotes but they have also now been shown to occur in cyanobacterial phages as well as their bacterial hosts.


Pssm-ID: 459629  Cd Length: 100  Bit Score: 105.00  E-value: 2.35e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609168    43 EDEMKEGRYEVRAELPGVDPDkDVDIMVRDGQLTIKAERTEQK--DFDGRSEFAYGSFVRTVSLPVGADEDDIKATYDKG 120
Cdd:pfam00011   1 DIKEDEDAFEVRLDVPGFKPE-ELKVKVEDNRLLVKGEHEEEKedDHGLRSERSYGSFSRKFTLPENADPDKVKASLKDG 79

                          90       100
                  ....*....|....*....|.
gi 15609168   121 ILTVSVAVSEGKPTEKHIQIR 141
Cdd:pfam00011  80 VLTVTVPKLEPEPKERRIQIQ 100
IbpA COG0071
Small heat shock protein IbpA, HSP20 family [Posttranslational modification, protein turnover, ...
 48-143 6.27e-28

Small heat shock protein IbpA, HSP20 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 439841  Cd Length: 105  Bit Score: 99.07  E-value: 6.27e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609168  48 EGRYEVRAELPGVDPDkDVDIMVRDGQLTIKAERTEQKDFDG----RSEFAYGSFVRTVSLPVGADEDDIKATYDKGILT 123
Cdd:COG0071   8 DDAYVITADLPGVDKE-DIDVTVEGNVLTISGERKEEEEEEGenylRRERRYGSFERSFTLPDDVDVDKIEASYENGVLT 86

                        90       100
                ....*....|....*....|
gi 15609168 124 VSVAVSEgKPTEKHIQIRST 143
Cdd:COG0071  87 ITLPKAE-EAKPRKIEIKAG 105
ACD_sHsps-like cd06464
Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). ...
 47-126 2.96e-26

Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally active as large oligomers consisting of multiple subunits, and are believed to be ATP-independent chaperones that prevent aggregation and are important in refolding in combination with other Hsps.


Pssm-ID: 107221  Cd Length: 88  Bit Score: 94.54  E-value: 2.96e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609168  47 KEGRYEVRAELPGVDPDkDVDIMVRDGQLTIKAERTEQKDFDG---RSEFAYGSFVRTVSLPVGADEDDIKATYDKGILT 123
Cdd:cd06464   5 TDDAYVVEADLPGFKKE-DIKVEVEDGVLTISGEREEEEEEEEnylRRERSYGSFSRSFRLPEDVDPDKIKASLENGVLT 83


                ...
gi 15609168 124 VSV 126
Cdd:cd06464  84 ITL 86
 
Name Accession Description Interval E-value
HSP20 pfam00011
Hsp20/alpha crystallin family; Not only do small heat-shock-proteins occur in eukaryotes and ...
 43-141 2.35e-30

Hsp20/alpha crystallin family; Not only do small heat-shock-proteins occur in eukaryotes and prokaryotes but they have also now been shown to occur in cyanobacterial phages as well as their bacterial hosts.


Pssm-ID: 459629  Cd Length: 100  Bit Score: 105.00  E-value: 2.35e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609168    43 EDEMKEGRYEVRAELPGVDPDkDVDIMVRDGQLTIKAERTEQK--DFDGRSEFAYGSFVRTVSLPVGADEDDIKATYDKG 120
Cdd:pfam00011   1 DIKEDEDAFEVRLDVPGFKPE-ELKVKVEDNRLLVKGEHEEEKedDHGLRSERSYGSFSRKFTLPENADPDKVKASLKDG 79

                          90       100
                  ....*....|....*....|.
gi 15609168   121 ILTVSVAVSEGKPTEKHIQIR 141
Cdd:pfam00011  80 VLTVTVPKLEPEPKERRIQIQ 100
IbpA COG0071
Small heat shock protein IbpA, HSP20 family [Posttranslational modification, protein turnover, ...
 48-143 6.27e-28

Small heat shock protein IbpA, HSP20 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 439841  Cd Length: 105  Bit Score: 99.07  E-value: 6.27e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609168  48 EGRYEVRAELPGVDPDkDVDIMVRDGQLTIKAERTEQKDFDG----RSEFAYGSFVRTVSLPVGADEDDIKATYDKGILT 123
Cdd:COG0071   8 DDAYVITADLPGVDKE-DIDVTVEGNVLTISGERKEEEEEEGenylRRERRYGSFERSFTLPDDVDVDKIEASYENGVLT 86

                        90       100
                ....*....|....*....|
gi 15609168 124 VSVAVSEgKPTEKHIQIRST 143
Cdd:COG0071  87 ITLPKAE-EAKPRKIEIKAG 105
ACD_sHsps-like cd06464
Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). ...
 47-126 2.96e-26

Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally active as large oligomers consisting of multiple subunits, and are believed to be ATP-independent chaperones that prevent aggregation and are important in refolding in combination with other Hsps.


Pssm-ID: 107221  Cd Length: 88  Bit Score: 94.54  E-value: 2.96e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609168  47 KEGRYEVRAELPGVDPDkDVDIMVRDGQLTIKAERTEQKDFDG---RSEFAYGSFVRTVSLPVGADEDDIKATYDKGILT 123
Cdd:cd06464   5 TDDAYVVEADLPGFKKE-DIKVEVEDGVLTISGEREEEEEEEEnylRRERSYGSFSRSFRLPEDVDPDKIKASLENGVLT 83


                ...
gi 15609168 124 VSV 126
Cdd:cd06464  84 ITL 86
ACD_sHsps_p23-like cd00298
This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small ...
 47-126 2.79e-19

This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is this ACD. sHsps are generally active as large oligomers consisting of multiple subunits, and are believed to be ATP-independent chaperones that prevent aggregation and are important in refolding in combination with other Hsps. p23 is a cochaperone of the Hsp90 chaperoning pathway. It binds Hsp90 and participates in the folding of a number of Hsp90 clients including the progesterone receptor. p23 also has a passive chaperoning activity. p23 in addition may act as the cytosolic prostaglandin E2 synthase. Included in this family is the p23-like C-terminal CHORD-SGT1 (CS) domain of suppressor of G2 allele of Skp1 (Sgt1) and the p23-like domains of human butyrate-induced transcript 1 (hB-ind1), NUD (nuclear distribution) C, Melusin, and NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR).


Pssm-ID: 107219  Cd Length: 80  Bit Score: 76.47  E-value: 2.79e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609168  47 KEGRYEVRAELPGVDPDkDVDIMVRDGQLTIKAERTEQKDfdgrSEFAYGSFVRTVSLPVGADEDDIKATYDKGILTVSV 126
Cdd:cd00298   4 TDDEVVVTVDLPGVKKE-DIKVEVEDNVLTISGKREEEEE----RERSYGEFERSFELPEDVDPEKSKASLENGVLEITL 78
ACD_LpsHSP_like cd06471
Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to ...
 47-126 9.08e-19

Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers consisting of multiple subunits. Transcription of the genes encoding Lp HSP 18.5, 18.55 and 19.3 is regulated by a variety of stresses including heat, cold and ethanol. Early growing L. plantarum cells contain elevated levels of these mRNAs which rapidly fall of as the cells enter stationary phase. Also belonging to this group is Bifidobacterium breve (Bb) HSP20 and Oenococcus oenis (syn. Leuconostoc oenos) (Oo) HSP18. Transcription of the gene encoding BbHSP20 is strongly induced following heat or osmotic shock, and that of the gene encoding OoHSP18 following heat, ethanol or acid shock. OoHSP18 is peripherally associated with the cytoplasmic membrane.


Pssm-ID: 107228  Cd Length: 93  Bit Score: 75.21  E-value: 9.08e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609168  47 KEGRYEVRAELPGVDPDkDVDIMVRDGQLTIKAER---TEQKDFDG---RSEFAYGSFVRTVSLPvGADEDDIKATYDKG 120
Cdd:cd06471   8 TDDEYIVEADLPGFKKE-DIKLDYKDGYLTISAKRdesKDEKDKKGnyiRRERYYGSFSRSFYLP-NVDEEEIKAKYENG 85


                ....*.
gi 15609168 121 ILTVSV 126
Cdd:cd06471  86 VLKITL 91
ACD_ScHsp26_like cd06472
Alpha crystallin domain (ACD) found in Saccharomyces cerevisiae (Sc) small heat shock protein ...
 51-126 1.24e-11

Alpha crystallin domain (ACD) found in Saccharomyces cerevisiae (Sc) small heat shock protein (Hsp)26 and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers consisting of multiple subunits. ScHsp26 is temperature-regulated, it switches from an inactive to a chaperone-active form upon elevation in temperature. It associates into large 24-mers storage forms which upon heat shock disassociate into dimers. These dimers initiate the interaction with non-native substrate proteins and re-assemble into large globular assemblies having one monomer of substrate bound per dimer. This group also contains Arabidopsis thaliana (Ath) Hsp15.7, a peroxisomal matrix protein which can complement the morphological phenotype of S. cerevisiae mutants deficient in Hsps26. AthHsp15.7 is minimally expressed under normal conditions and is strongly induced by heat and oxidative stress. Also belonging to this group is wheat HSP16.9 which differs in quaternary structure from the shell-type particles of ScHsp26, it assembles as a dodecameric double disc, with each disc organized as a trimer of dimers.


Pssm-ID: 107229  Cd Length: 92  Bit Score: 56.93  E-value: 1.24e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609168  51 YEVRAELPGVDPDkDVDIMVRDGQ-LTIKAERTEQKDFDG----RSEFAYGSFVRTVSLPVGADEDDIKATYDKGILTVS 125
Cdd:cd06472  11 HVFKADVPGVKKE-DVKVEVEDGRvLRISGERKKEEEKKGddwhRVERSSGRFVRRFRLPENADADEVKAFLENGVLTVT 89


                .
gi 15609168 126 V 126
Cdd:cd06472  90 V 90
metazoan_ACD cd06526
Alpha-crystallin domain (ACD) of metazoan alpha-crystallin-type small(s) heat shock proteins ...
 47-126 9.81e-08

Alpha-crystallin domain (ACD) of metazoan alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally active as large oligomers consisting of multiple subunits, and are believed to be ATP-independent chaperones that prevent aggregation and are important in refolding in combination with other Hsps.


Pssm-ID: 107247  Cd Length: 83  Bit Score: 46.74  E-value: 9.81e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609168  47 KEGRYEVRAELPGVDPDkDVDIMVRDGQLTIKAERTEQKDFDGRSefaYGSFVRTVSLPVGADEDDIKATY-DKGILTVS 125
Cdd:cd06526   5 DDEKFQVTLDVKGFKPE-ELKVKVSDNKLVVEGKHEEREDEHGYV---SREFTRRYQLPEGVDPDSVTSSLsSDGVLTIE 80


                .
gi 15609168 126 V 126
Cdd:cd06526  81 A 81
ACD_HspB10 cd06482
Alpha crystallin domain (ACD) found in mammalian small heat shock protein (sHsp) HspB10, also ...
 59-120 1.21e-06

Alpha crystallin domain (ACD) found in mammalian small heat shock protein (sHsp) HspB10, also known as sperm outer dense fiber protein (ODFP), and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers consisting of multiple subunits. Human (h) HspB10 occurs exclusively in the axoneme of sperm cells and may have a cytoskeletal role.


Pssm-ID: 107237  Cd Length: 87  Bit Score: 44.10  E-value: 1.21e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15609168  59 GVDPDKdVDIMVRDGQLTIKAERTEQKDFDGRSEFAYGSFVRTVSLPVGADEDDIKATYDKG 120
Cdd:cd06482  18 GFEPDQ-VKVKVKDGKVQVSAERENRYDCLGSKKYSYMNICKEFSLPPGVDEKDVTYSYGLG 78
ACD_IbpA-B_like cd06470
Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins ...
 48-125 1.21e-05

Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers consisting of multiple subunits. IbpA and IbpB are produced during high-level production of various heterologous proteins, specifically human prorenin, renin and bovine insulin-like growth factor 2 (bIGF-2), and are strongly associated with inclusion bodies containing these heterologous proteins. IbpA and IbpB work as an integrated system to stabilize thermally aggregated proteins in a disaggregation competent state. The chaperone activity of IbpB is also significantly elevated as the temperature increases from normal to heat shock. The high temperature results in the disassociation of 2-3-MDa IbpB oligomers into smaller approximately 600-kDa structures. This elevated activity seen under heat shock conditions is retained for an extended period of time after the temperature is returned to normal. IbpA also forms multimers.


Pssm-ID: 107227  Cd Length: 90  Bit Score: 41.36  E-value: 1.21e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15609168  48 EGRYEVRAELPGVDPDkDVDIMVRDGQLTIKAERTEQKDFDGR---SEFAYGSFVRTVSLpvgadEDDIK---ATYDKGI 121
Cdd:cd06470  10 ENNYRITLAVAGFSED-DLEIEVENNQLTVTGKKADEENEEREylhRGIAKRAFERSFNL-----ADHVKvkgAELENGL 83


                ....
gi 15609168 122 LTVS 125
Cdd:cd06470  84 LTID 87
ArsA_HSP20 pfam17886
HSP20-like domain found in ArsA; This domain is found at the C-terminus of ArsA like proteins. ...
 48-125 4.91e-05

HSP20-like domain found in ArsA; This domain is found at the C-terminus of ArsA like proteins. This domain is related to HSP20.


Pssm-ID: 436117  Cd Length: 63  Bit Score: 39.00  E-value: 4.91e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15609168    48 EGRYEVRAELPGVDPDkDVDIMVRDGQLTIKAerteqkdfdgrsefayGSFVRTVSLPVG-ADEDDIKATYDKGILTVS 125
Cdd:pfam17886   1 DGGYVLRLRLPFVDKE-DVDLSRSGDELIIKI----------------GNFRRNITLPRSlARLEVTGAKFEDGVLRIR 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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