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Conserved domains on  [gi|15595464|ref|NP_248958|]
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hypothetical protein PA0267 [Pseudomonas aeruginosa PAO1]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HDOD pfam08668
HDOD domain;
162-349 1.88e-49

HDOD domain;


:

Pssm-ID: 430141 [Multi-domain]  Cd Length: 196  Bit Score: 165.48  E-value: 1.88e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464   162 PLLADVRAASDRCLSAEEHPLRVLEAEFGRDPQITAGLIAAANSAARHVGPACQTLGQALRRLGLGHSLNLVLGFSLQRA 241
Cdd:pfam08668   2 PTLPDVALRILALLNDPDSSISDIAELISRDPALTARLLRLANSAYYGLRRPISTISQAVVLLGLRTVRNLALGISVKRI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464   242 IQlGEPLLAERAMHFWDLSQRCADIAWELADALGADV-ERCYTAGLLHRLGDLALLRTLQDW-------CDGGGALDEAR 313
Cdd:pfam08668  82 FR-GTPPLGFDLKGFWEHSLACALAARLLARRLGLDDpEEAFLAGLLHDIGKLILLSLLPDKyeellekAAEEGISLLEA 160

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 15595464   314 LDELLGRFGASFGSALRARWRLPLELRRLIAAAYQF 349
Cdd:pfam08668 161 ERELLGTDHAEVGAALLERWNLPEELVEAIAYHHNP 196
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 10-127 6.87e-21

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


:

Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 87.72  E-value: 6.87e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  10 ILIADPDPWSRDLLGQLVLGVRCDARLVLCGDGGEALAHCRRRRFALILAELNLPQVDGFELLREarLRRSVAEQPFILI 89
Cdd:COG4565   6 VLIVEDDPMVAELLRRYLERLPGFEVVGVASSGEEALALLAEHRPDLILLDIYLPDGDGLELLRE--LRARGPDVDVIVI 83

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 15595464  90 SDRADQASVRAAVALAPTAYLVKPFQAENLMQRLRGLL 127
Cdd:COG4565  84 TAARDPETVREALRAGVVDYLIKPFTFERLREALERYL 121
 
Name Accession Description Interval E-value
HDOD pfam08668
HDOD domain;
162-349 1.88e-49

HDOD domain;


Pssm-ID: 430141 [Multi-domain]  Cd Length: 196  Bit Score: 165.48  E-value: 1.88e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464   162 PLLADVRAASDRCLSAEEHPLRVLEAEFGRDPQITAGLIAAANSAARHVGPACQTLGQALRRLGLGHSLNLVLGFSLQRA 241
Cdd:pfam08668   2 PTLPDVALRILALLNDPDSSISDIAELISRDPALTARLLRLANSAYYGLRRPISTISQAVVLLGLRTVRNLALGISVKRI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464   242 IQlGEPLLAERAMHFWDLSQRCADIAWELADALGADV-ERCYTAGLLHRLGDLALLRTLQDW-------CDGGGALDEAR 313
Cdd:pfam08668  82 FR-GTPPLGFDLKGFWEHSLACALAARLLARRLGLDDpEEAFLAGLLHDIGKLILLSLLPDKyeellekAAEEGISLLEA 160

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 15595464   314 LDELLGRFGASFGSALRARWRLPLELRRLIAAAYQF 349
Cdd:pfam08668 161 ERELLGTDHAEVGAALLERWNLPEELVEAIAYHHNP 196
HDOD COG1639
HD-like signal output (HDOD) domain, no enzymatic activity [Signal transduction mechanisms];
152-385 7.68e-29

HD-like signal output (HDOD) domain, no enzymatic activity [Signal transduction mechanisms];


Pssm-ID: 441246 [Multi-domain]  Cd Length: 244  Bit Score: 112.75  E-value: 7.68e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464 152 ERARDSAEGAPLLADVRAASDRCLSAEEHPLRVLEAEFGRDPQITAGLIAAANSAARHVGPACQTLGQALRRLGLGHSLN 231
Cdd:COG1639   1 EELLKGILELPPLPEVALRLLELLADPDASLAELARLISQDPALTARLLRLANSAYYGLGRKITSVEQAVVLLGLDTVRN 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464 232 LVLGFSLQRAIQLGEPLLAERAMHFWDLSQRCADIAWELADALG-ADVERCYTAGLLHRLGDLALLRTLQDW-------C 303
Cdd:COG1639  81 LALALALRQLFSAKLPAYGLDLRRFWRHSLAVAAAARALARRLGlLDPEEAFLAGLLHDIGKLVLLSLFPEEyaellalA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464 304 DGGGALDEARLDELLGRFGASFGSALRARWRLPLELRRLIAAAYQFGGVLSREEL--ILSLATQAASLPEDDAEQLAESK 381
Cdd:COG1639 161 EADGLSLAEAEREVLGTDHAELGAALARKWGLPEELVEAIRYHHDPEAAGEHRRLaaLVHLANRLARALGEEDPALPEAA 240


                ....
gi 15595464 382 AARM 385
Cdd:COG1639 241 LALL 244
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 10-127 6.87e-21

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 87.72  E-value: 6.87e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  10 ILIADPDPWSRDLLGQLVLGVRCDARLVLCGDGGEALAHCRRRRFALILAELNLPQVDGFELLREarLRRSVAEQPFILI 89
Cdd:COG4565   6 VLIVEDDPMVAELLRRYLERLPGFEVVGVASSGEEALALLAEHRPDLILLDIYLPDGDGLELLRE--LRARGPDVDVIVI 83

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 15595464  90 SDRADQASVRAAVALAPTAYLVKPFQAENLMQRLRGLL 127
Cdd:COG4565  84 TAARDPETVREALRAGVVDYLIKPFTFERLREALERYL 121
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 11-113 3.30e-17

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 76.50  E-value: 3.30e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  11 LIADPDPWSRDLLGQLVlgVRCDARLVLCGDGGEALAHCRRRRFALILAELNLPQVDGFELLReaRLRRSVAEQPFILIS 90
Cdd:cd00156   1 LIVDDDPAIRELLKSLL--EREGYEVDTAADGEEALELLREERPDLVLLDLMMPGMDGLELLR--KLRELPPDIPVIVLT 76

                        90       100
                ....*....|....*....|...
gi 15595464  91 DRADQASVRAAVALAPTAYLVKP 113
Cdd:cd00156  77 AKADEEDAVRALELGADDYLVKP 99
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 10-124 2.86e-12

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 62.94  E-value: 2.86e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464    10 ILIADPDPWSRDLLGQLV--LGVRCDArlvlCGDGGEALAHCRRRRFALILAELNLPQVDGFELLReaRLRRSVAEQPFI 87
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLekEGYVVAE----ADDGKEALELLKEERPDLILLDINMPGMDGLELLK--RIRRRDPTTPVI 74

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 15595464    88 LISDRADQASVRAAVALAPTAYLVKPFQAENLMQRLR 124
Cdd:pfam00072  75 ILTAHGDEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
PRK10610 PRK10610
chemotaxis protein CheY;
41-129 5.23e-11

chemotaxis protein CheY;


Pssm-ID: 170568 [Multi-domain]  Cd Length: 129  Bit Score: 59.99  E-value: 5.23e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464   41 DGGEALAHCRRRRFALILAELNLPQVDGFELLREARLRRSVAEQPFILISDRADQASVRAAVALAPTAYLVKPFQAENLM 120
Cdd:PRK10610  38 DGVDALNKLQAGGFGFVISDWNMPNMDGLELLKTIRADGAMSALPVLMVTAEAKKENIIAAAQAGASGYVVKPFTAATLE 117


                 ....*....
gi 15595464  121 QRLRGLLLK 129
Cdd:PRK10610 118 EKLNKIFEK 126
 
Name Accession Description Interval E-value
HDOD pfam08668
HDOD domain;
162-349 1.88e-49

HDOD domain;


Pssm-ID: 430141 [Multi-domain]  Cd Length: 196  Bit Score: 165.48  E-value: 1.88e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464   162 PLLADVRAASDRCLSAEEHPLRVLEAEFGRDPQITAGLIAAANSAARHVGPACQTLGQALRRLGLGHSLNLVLGFSLQRA 241
Cdd:pfam08668   2 PTLPDVALRILALLNDPDSSISDIAELISRDPALTARLLRLANSAYYGLRRPISTISQAVVLLGLRTVRNLALGISVKRI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464   242 IQlGEPLLAERAMHFWDLSQRCADIAWELADALGADV-ERCYTAGLLHRLGDLALLRTLQDW-------CDGGGALDEAR 313
Cdd:pfam08668  82 FR-GTPPLGFDLKGFWEHSLACALAARLLARRLGLDDpEEAFLAGLLHDIGKLILLSLLPDKyeellekAAEEGISLLEA 160

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 15595464   314 LDELLGRFGASFGSALRARWRLPLELRRLIAAAYQF 349
Cdd:pfam08668 161 ERELLGTDHAEVGAALLERWNLPEELVEAIAYHHNP 196
HDOD COG1639
HD-like signal output (HDOD) domain, no enzymatic activity [Signal transduction mechanisms];
152-385 7.68e-29

HD-like signal output (HDOD) domain, no enzymatic activity [Signal transduction mechanisms];


Pssm-ID: 441246 [Multi-domain]  Cd Length: 244  Bit Score: 112.75  E-value: 7.68e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464 152 ERARDSAEGAPLLADVRAASDRCLSAEEHPLRVLEAEFGRDPQITAGLIAAANSAARHVGPACQTLGQALRRLGLGHSLN 231
Cdd:COG1639   1 EELLKGILELPPLPEVALRLLELLADPDASLAELARLISQDPALTARLLRLANSAYYGLGRKITSVEQAVVLLGLDTVRN 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464 232 LVLGFSLQRAIQLGEPLLAERAMHFWDLSQRCADIAWELADALG-ADVERCYTAGLLHRLGDLALLRTLQDW-------C 303
Cdd:COG1639  81 LALALALRQLFSAKLPAYGLDLRRFWRHSLAVAAAARALARRLGlLDPEEAFLAGLLHDIGKLVLLSLFPEEyaellalA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464 304 DGGGALDEARLDELLGRFGASFGSALRARWRLPLELRRLIAAAYQFGGVLSREEL--ILSLATQAASLPEDDAEQLAESK 381
Cdd:COG1639 161 EADGLSLAEAEREVLGTDHAELGAALARKWGLPEELVEAIRYHHDPEAAGEHRRLaaLVHLANRLARALGEEDPALPEAA 240


                ....
gi 15595464 382 AARM 385
Cdd:COG1639 241 LALL 244
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 10-127 6.87e-21

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 87.72  E-value: 6.87e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  10 ILIADPDPWSRDLLGQLVLGVRCDARLVLCGDGGEALAHCRRRRFALILAELNLPQVDGFELLREarLRRSVAEQPFILI 89
Cdd:COG4565   6 VLIVEDDPMVAELLRRYLERLPGFEVVGVASSGEEALALLAEHRPDLILLDIYLPDGDGLELLRE--LRARGPDVDVIVI 83

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 15595464  90 SDRADQASVRAAVALAPTAYLVKPFQAENLMQRLRGLL 127
Cdd:COG4565  84 TAARDPETVREALRAGVVDYLIKPFTFERLREALERYL 121
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 3-127 2.77e-20

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 85.67  E-value: 2.77e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464   3 AAKKAPVILIADPDPWSRDLLGQLVlgVRCDARLVLCGDGGEALAHCRRRRFALILAELNLPQVDGFELLREARLRRSVA 82
Cdd:COG0784   1 PPLGGKRILVVDDNPDNRELLRRLL--ERLGYEVTTAEDGAEALELLRAGPPDLILLDINMPGMDGLELLRRIRALPRLP 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 15595464  83 EQPFILISDRADQASVRAAVALAPTAYLVKPFQAENLMQRLRGLL 127
Cdd:COG0784  79 DIPIIALTAYADEEDRERALEAGADDYLTKPVDPEELLEALRRLL 123
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 10-162 5.29e-20

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 86.50  E-value: 5.29e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  10 ILIADPDPWSRDLLGQLVlgVRCDARLVLCGDGGEALAHCRRRRFALILAELNLPQVDGFELLREARLRRSVAEQPFILI 89
Cdd:COG3706   4 ILVVDDDPTNRKLLRRLL--EAAGYEVVEAADGEEALELLQEHRPDLILLDLEMPDMDGLELCRRLRADPRTADIPIIFL 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15595464  90 SDRADQASVRAAVALAPTAYLVKPFQAENLMQRLRGLLLKGDEVVACPLPERDAgENLEAFLERARDSAEGAP 162
Cdd:COG3706  82 TALDDEEDRARALEAGADDYLTKPFDPEELLARVDLVARYGGEEFAILLPGTDL-EGALAVAERIREAVAELP 153
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 6-127 4.75e-18

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 82.52  E-value: 4.75e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464   6 KAPVILIADPDPWSRDLLGQLVLgvRCDARLVLCGDGGEALAHCRRRRFALILAELNLPQVDGFELLREARLRRSVAEQP 85
Cdd:COG3437   5 QAPTVLIVDDDPENLELLRQLLR--TLGYDVVTAESGEEALELLLEAPPDLILLDVRMPGMDGFELLRLLRADPSTRDIP 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 15595464  86 FILISDRADQASVRAAVALAPTAYLVKPFQAENLMQRLRGLL 127
Cdd:COG3437  83 VIFLTALADPEDRERALEAGADDYLTKPFDPEELLARVRNAL 124
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 11-113 3.30e-17

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 76.50  E-value: 3.30e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  11 LIADPDPWSRDLLGQLVlgVRCDARLVLCGDGGEALAHCRRRRFALILAELNLPQVDGFELLReaRLRRSVAEQPFILIS 90
Cdd:cd00156   1 LIVDDDPAIRELLKSLL--EREGYEVDTAADGEEALELLREERPDLVLLDLMMPGMDGLELLR--KLRELPPDIPVIVLT 76

                        90       100
                ....*....|....*....|...
gi 15595464  91 DRADQASVRAAVALAPTAYLVKP 113
Cdd:cd00156  77 AKADEEDAVRALELGADDYLVKP 99
REC_TPR cd17589
phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR) ...
 10-123 3.38e-17

phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR)-containing response regulators; Response regulators share the common phosphoacceptor REC domain and different output domains. This subfamily contains uncharacterized response regulators with TPR repeats as the effector or output domain, which might contain between 3 to 16 TPR repeats (each about 34 amino acids). TPR-containing proteins occur in all domains of life and the abundance of TPR-containing proteins in a bacterial proteome is not indicative of virulence. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members in this subfamily may contain inactive REC domains lacking canonical metal-binding and active site residues.


Pssm-ID: 381123 [Multi-domain]  Cd Length: 115  Bit Score: 76.92  E-value: 3.38e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  10 ILIADPDPWSRDLLGQLV--LGVRcdaRLVLCGDGGEALAHCRRRRFALILAELNL-PQVDGFELLREARLRRSVAEQP- 85
Cdd:cd17589   1 FLIVDDQPTFRSMLKSMLrsLGVT---RIDTASSGEEALRMCENKTYDIVLCDYNLgKGKNGQQLLEELRHKKLISPSTv 77

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 15595464  86 FILISDRADQASVRAAVALAPTAYLVKPFQAENLMQRL 123
Cdd:cd17589  78 FIMVTGESSRAMVLSALELEPDDYLLKPFTVSELRERL 115
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 8-127 7.02e-16

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 75.76  E-value: 7.02e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464   8 PVILIADPDPWSRDLLGQLVLgvRCDARLVLCGDGGEALAHCRRRRFALILAELNLPQVDGFELLReaRLRRSVAEQPFI 87
Cdd:COG0745   2 PRILVVEDDPDIRELLADALE--REGYEVDTAADGEEALELLEEERPDLILLDLMLPGMDGLEVCR--RLRARPSDIPII 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 15595464  88 LISDRADQASVRAAVALAPTAYLVKPFQAENLMQRLRGLL 127
Cdd:COG0745  78 MLTARDDEEDRVRGLEAGADDYLTKPFDPEELLARIRALL 117
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 10-113 1.09e-15

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 72.11  E-value: 1.09e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  10 ILIADPDPWSRDLLGQLvLGVRCDARLVL-CGDGGEALAHCRRRRFALILAELNLPQVDGFELLREarLRRSVAEQPFIL 88
Cdd:COG4753   2 VLIVDDEPLIREGLKRI-LEWEAGFEVVGeAENGEEALELLEEHKPDLVITDINMPGMDGLELLEA--IRELDPDTKIII 78

                        90       100
                ....*....|....*....|....*
gi 15595464  89 ISDRADQASVRAAVALAPTAYLVKP 113
Cdd:COG4753  79 LSGYSDFEYAQEAIKLGADDYLLKP 103
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 6-127 2.06e-15

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 77.31  E-value: 2.06e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464   6 KAPVILIADPDPWSRDLLGQLVLgvRCDARLVLCGDGGEALAHCRRRRFALILAELNLPQVDGFELLREarLRRSVAEQP 85
Cdd:COG2204   1 SMARILVVDDDPDIRRLLKELLE--RAGYEVETAASGEEALALLREEPPDLVLLDLRMPGMDGLELLRE--LRALDPDLP 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 15595464  86 FILISDRADQASVRAAVALAPTAYLVKPFQAENLMQRLRGLL 127
Cdd:COG2204  77 VILLTGYGDVETAVEAIKAGAFDYLTKPFDLEELLAAVERAL 118
REC_typeB_ARR-like cd17584
phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and ...
 10-120 1.84e-13

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381121 [Multi-domain]  Cd Length: 115  Bit Score: 66.50  E-value: 1.84e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  10 ILIADPDPWSRDLLGQLVLgvRCDARLVLCGDGGEALAHCR--RRRFALILAELNLPQVDGFELLREARLRRSVaeqPFI 87
Cdd:cd17584   1 VLVVDDDPTCLAILKRMLL--RCGYQVTTCTDAEEALSMLRenKDEFDLVITDVHMPDMDGFEFLELIRLEMDL---PVI 75

                        90       100       110
                ....*....|....*....|....*....|...
gi 15595464  88 LISDRADQASVRAAVALAPTAYLVKPFQAENLM 120
Cdd:cd17584  76 MMSADGSTSTVMKGLAHGACDYLLKPVSIEDLK 108
REC_CheY_CheY3 cd19923
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY ...
 41-127 6.87e-13

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY3, Escherichia coli CheY, and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381150 [Multi-domain]  Cd Length: 119  Bit Score: 65.05  E-value: 6.87e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  41 DGGEALAHCRRRRFALILAELNLPQVDGFELLREARLRRSVAEQPFILISDRADQASVRAAVALAPTAYLVKPFQAENLM 120
Cdd:cd19923  33 DGVDALEKLKAGGFDFVITDWNMPNMDGLELLKTIRADGALSHLPVLMVTAEAKKENVIAAAQAGVNNYIVKPFTAATLK 112


                ....*..
gi 15595464 121 QRLRGLL 127
Cdd:cd19923 113 EKLEKIF 119
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 10-126 1.23e-12

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 64.00  E-value: 1.23e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  10 ILIADPDPWSRDLLGQLVLGVrCDARLVLCGDGGEALAHCRRRRFALILAELNLPQVDGFELLREARLRRSVAEQPFILI 89
Cdd:cd17551   3 ILIVDDNPTNLLLLEALLRSA-GYLEVVSFTDPREALAWCRENPPDLILLDYMMPGMDGLEFIRRLRALPGLEDVPIVMI 81

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 15595464  90 SDRADQASVRAAVALAPTAYLVKPFQAENLMQRLRGL 126
Cdd:cd17551  82 TADTDREVRLRALEAGATDFLTKPFDPVELLARVRNL 118
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 10-124 2.86e-12

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 62.94  E-value: 2.86e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464    10 ILIADPDPWSRDLLGQLV--LGVRCDArlvlCGDGGEALAHCRRRRFALILAELNLPQVDGFELLReaRLRRSVAEQPFI 87
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLekEGYVVAE----ADDGKEALELLKEERPDLILLDINMPGMDGLELLK--RIRRRDPTTPVI 74

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 15595464    88 LISDRADQASVRAAVALAPTAYLVKPFQAENLMQRLR 124
Cdd:pfam00072  75 ILTAHGDEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
 10-127 8.20e-12

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 61.93  E-value: 8.20e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  10 ILIADPDPWSRDLLGqLVLGvrcDA--RLVLCGDGGEALAHCRRRRFALILAELNLPQVDGFELLREARLRRSVAEQPFI 87
Cdd:cd17562   3 ILAVDDSASIRQMVS-FTLR---GAgyEVVEAADGRDALSKAQSKKFDLIITDQNMPNMDGIELIKELRKLPAYKFTPIL 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 15595464  88 LI---SDRADQASVRAAVAlapTAYLVKPFQAENLMQRLRGLL 127
Cdd:cd17562  79 MLtteSSDEKKQEGKAAGA---TGWLVKPFDPEQLLEVVKKVL 118
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 10-123 1.33e-11

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 60.95  E-value: 1.33e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  10 ILIADPDPWSRDLLGQLV--LGVRCDArlvlCGDGGEALAHCRRRRFALILAELNLPQVDGFELLReaRLRRSVAEQ--- 84
Cdd:cd17546   1 VLVVDDNPVNRKVLKKLLekLGYEVDV----AENGQEALELLKEEPFDLVLMDLQMPVMDGLEATR--RIRELEGGGrrt 74

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 15595464  85 PFILISDRADQASVRAAVALAPTAYLVKPFQAENLMQRL 123
Cdd:cd17546  75 PIIALTANALEEDREKCLEAGMDDYLSKPVKLDQLKEVL 113
PRK10610 PRK10610
chemotaxis protein CheY;
41-129 5.23e-11

chemotaxis protein CheY;


Pssm-ID: 170568 [Multi-domain]  Cd Length: 129  Bit Score: 59.99  E-value: 5.23e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464   41 DGGEALAHCRRRRFALILAELNLPQVDGFELLREARLRRSVAEQPFILISDRADQASVRAAVALAPTAYLVKPFQAENLM 120
Cdd:PRK10610  38 DGVDALNKLQAGGFGFVISDWNMPNMDGLELLKTIRADGAMSALPVLMVTAEAKKENIIAAAQAGASGYVVKPFTAATLE 117


                 ....*....
gi 15595464  121 QRLRGLLLK 129
Cdd:PRK10610 118 EKLNKIFEK 126
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 8-115 5.38e-11

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 59.52  E-value: 5.38e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464   8 PVILIADPDPWSRDLLGQLVLGvrCDARLVLCGDGGEALAHCRRRRFALILAELNLPQVDGFELLREarLRRSVAEQPFI 87
Cdd:cd17555   1 ATILVIDDDEVVRESIAAYLED--SGFQVLQAADGRQGLELFRSEQPDLVLCDLRMPEMDGLEVLKQ--ITKESPDTPVI 76

                        90       100
                ....*....|....*....|....*...
gi 15595464  88 LISDRADQASVRAAVALAPTAYLVKPFQ 115
Cdd:cd17555  77 VVSGAGVMSDAVEALRLGAWDYLTKPIE 104
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 10-123 1.43e-10

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 58.41  E-value: 1.43e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  10 ILIADPDPWSRDLLGQLVLGVRCDARLVLCGDGGEALAHCRRRRFALILAELNLPQVDGFELLREarLRRSVAEQPFILI 89
Cdd:cd19925   3 VLIVEDDPMVAEIHRAYVEQVPGFTVIGTAGTGEEALKLLKERQPDLILLDIYLPDGNGLDLLRE--LRAAGHDVDVIVV 80

                        90       100       110
                ....*....|....*....|....*....|....
gi 15595464  90 SDRADQASVRAAVALAPTAYLVKPFQAENLMQRL 123
Cdd:cd19925  81 TAANDVETVREALRLGVVDYLIKPFTFERLRQRL 114
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
 10-126 2.19e-10

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 57.81  E-value: 2.19e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  10 ILIADPDPWSRDLLgQLVL---GVRCdaRLVLCGDGGEALAHCRRR-------RFALILAELNLPQVDGFELLREARLRR 79
Cdd:cd17557   2 ILLVEDNPGDAELI-QEAFkeaGVPN--ELHVVRDGEEALDFLRGEgeyadapRPDLILLDLNMPRMDGFEVLREIKADP 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 15595464  80 SVAEQPFILISDRADQASVRAAVALAPTAYLVKPFQAENLMQRLRGL 126
Cdd:cd17557  79 DLRRIPVVVLTTSDAEEDIERAYELGANSYIVKPVDFEEFVEAIRSL 125
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
 8-124 4.73e-10

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 56.63  E-value: 4.73e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464   8 PVILIADPDPWSRDLLGQLVlgvRCDARLVLC-GDGGEALAHCRRRRFALILAELNLPQVDGFELLREARLRRSVaeqPF 86
Cdd:cd17619   1 PHILIVEDEPVTRATLKSYF---EQEGYDVSEaGDGEEMRQILARQDIDLVLLDINLPGKDGLSLTRELREQSEV---GI 74

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 15595464  87 ILISDRADQASVRAAVALAPTAYLVKPFQAENLMQRLR 124
Cdd:cd17619  75 ILVTGRDDEVDRIVGLEIGADDYVTKPFNPRELLVRAK 112
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 10-119 6.18e-10

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 58.43  E-value: 6.18e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  10 ILIADPDPWSRDLLGQLVLGVRCDaRLVLCGDGGEALAHCRRRRFALILAELNLPQVDGFELLREARLRRSVaeqPFILI 89
Cdd:COG3707   6 VLVVDDEPLRRADLREGLREAGYE-VVAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEERPA---PVILL 81

                        90       100       110
                ....*....|....*....|....*....|
gi 15595464  90 SDRADQASVRAAVALAPTAYLVKPFQAENL 119
Cdd:COG3707  82 TAYSDPELIERALEAGVSAYLVKPLDPEDL 111
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 7-125 1.67e-09

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 56.85  E-value: 1.67e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464   7 APVILIADPDPWSRDLLGQLVlgVRCDARLVLCGDGGEALAHCRRRRFALILAELNLPQVDGFELLREarLRRSVAEQPF 86
Cdd:COG4567   4 DRSLLLVDDDEAFARVLARAL--ERRGFEVTTAASVEEALALLEQAPPDYAVLDLRLGDGSGLDLIEA--LRERDPDARI 79

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 15595464  87 ILISDRADQASVRAAVALAPTAYLVKPFQAENLMQRLRG 125
Cdd:COG4567  80 VVLTGYASIATAVEAIKLGADDYLAKPADADDLLAALER 118
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
 10-127 3.34e-09

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 54.40  E-value: 3.34e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  10 ILIADPDPWSRDLLGQLVLGVRCDARLvlCGDGGEALAHCRRRRFALILAELNLPQVDGFELLREARLRRSVaeqPFILI 89
Cdd:cd17626   3 ILVVDDDAALAEMIGIVLRGEGFDPAF--CGDGTQALAAFREVRPDLVLLDLMLPGIDGIEVCRQIRAESGV---PIVML 77

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 15595464  90 SDRADQASVRAAVALAPTAYLVKPFQAENLMQRLRGLL 127
Cdd:cd17626  78 TAKSDTVDVVLGLESGADDYVAKPFKPKELVARIRARL 115
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
 38-127 4.00e-09

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 54.15  E-value: 4.00e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  38 LCGDGGEALAHCRRRRFALILAELNLPQVDGFELLReaRLRRSVAEQPFILISDRADQASVRAAVALAPTAYLVKPFQAE 117
Cdd:cd17625  26 VCFDGEEGLEYALSGIYDLIILDIMLPGMDGLEVLK--SLREEGIETPVLLLTALDAVEDRVKGLDLGADDYLPKPFSLA 103

                        90
                ....*....|
gi 15595464 118 NLMQRLRGLL 127
Cdd:cd17625 104 ELLARIRALL 113
REC_hyHK cd17598
phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase ...
 10-128 6.42e-09

phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase/response regulators; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase/response regulators contain all the elements of a classical TCS in a single polypeptide chain. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381128 [Multi-domain]  Cd Length: 118  Bit Score: 53.48  E-value: 6.42e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  10 ILIADPDPWSRDLLGQLVLGVRCDARLVlcGDGGEALAHCRRRRFALILAELNLPQVDGFELLREARLRRSVAEQPFILI 89
Cdd:cd17598   1 ILIVEDSPTQAEQLKHILEEQGYKVQVA--RNGREALAMLAEHRPTLVISDIVMPEMDGYELCRKIKSDPDLKDIPVILL 78

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 15595464  90 SDRADQASVRAAVALAPTAYLVKPFQAENLMQRLRGLLL 128
Cdd:cd17598  79 TTLSDPRDVIRGLECGADNFITKPYDEKYLLSRIKYILV 117
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
 40-127 8.26e-09

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 53.13  E-value: 8.26e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  40 GDGGEALAHCRRRRFALILAELNLPQVDGFELLReaRLRRSVAEQPFILISDRADQASVRAAVALAPTAYLVKPFQAENL 119
Cdd:cd17615  30 ADGAEALAAAREFRPDAVVLDIMLPDMDGLEVLR--RLRADGPDVPVLFLTAKDSVEDRIAGLTAGGDDYVTKPFSLEEV 107


                ....*...
gi 15595464 120 MQRLRGLL 127
Cdd:cd17615 108 VARLRALL 115
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 11-113 9.27e-09

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 52.41  E-value: 9.27e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  11 LIADPDPWSRDLLgQLVL---GVRCDArlvlCGDGGEALAHCRRRRFALILAELNLPQVDGFELLReaRLRRSVAEQPFI 87
Cdd:cd17574   1 LVVEDDEEIAELL-SDYLekeGYEVDT----AADGEEALELAREEQPDLIILDVMLPGMDGFEVCR--RLREKGSDIPII 73

                        90       100
                ....*....|....*....|....*.
gi 15595464  88 LISDRADQASVRAAVALAPTAYLVKP 113
Cdd:cd17574  74 MLTAKDEEEDKVLGLELGADDYITKP 99
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
 10-114 1.51e-08

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 52.11  E-value: 1.51e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  10 ILIADPDPWSRDLLGQLVLGVRCdaRLVLCGDGGEALAHCRRRRFALILAELNLPQVDGFELLREARLRRSVAEQPFILI 89
Cdd:cd17538   2 ILVVDDEPANRELLEALLSAEGY--EVLTADSGQEALALAEEELPDLILLDVMMPGMDGFEVCRRLKEDPETRHIPVIMI 79

                        90       100
                ....*....|....*....|....*...
gi 15595464  90 ---SDRADQasVRAAVALApTAYLVKPF 114
Cdd:cd17538  80 talDDREDR--IRGLEAGA-DDFLSKPI 104
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
 35-127 1.61e-08

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 52.28  E-value: 1.61e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  35 RLVLCGDGGEALAHCRRRRFALILAELNLPQVDGFELLREARLRRSVAEQPFILISDRADQASVRAAVALAPTAYLVKPF 114
Cdd:cd19937  23 EVVTAYDGEEALKRAKDEKPDLIILDLMLPGIDGLEVCRILRSDPKTSSIPIIMLTAKGEEFDKVLGLELGADDYITKPF 102

                        90
                ....*....|...
gi 15595464 115 QAENLMQRLRGLL 127
Cdd:cd19937 103 SPRELLARVKAVL 115
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 10-124 2.05e-08

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 52.13  E-value: 2.05e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  10 ILIADPDPWSRDLLGQLvLGVRCDARLVL-CGDGGEALAHCRRRRFALILAELNLPQVDGFELLReaRLRRSVAEQPFIL 88
Cdd:cd17535   1 VLIVDDHPLVREGLRRL-LESEPDIEVVGeAADGEEALALLRELRPDVVLMDLSMPGMDGIEALR--RLRRRYPDLKVIV 77

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 15595464  89 ISDRADQASVRAAVALAPTAYLVKPFQAENLMQRLR 124
Cdd:cd17535  78 LTAHDDPEYVLRALKAGAAGYLLKDSSPEELIEAIR 113
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
 10-124 1.19e-07

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 50.18  E-value: 1.19e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  10 ILIADPDPWSRDLLGQ-LVL-GVRCDArlvlCGDGGEALAHCRRRRFALILAELNLPQVDGFELLreARLRRSVAEQPFI 87
Cdd:cd17549   1 VLLVDDDADVREALQQtLELaGFRVRA----FADAEEALAALSPDFPGVVISDIRMPGMDGLELL--AQIRELDPDLPVI 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 15595464  88 LISDRADqasVRAAV-ALAPTAY--LVKPFQAENLMQRLR 124
Cdd:cd17549  75 LITGHGD---VPMAVeAMRAGAYdfLEKPFDPERLLDVVR 111
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 10-124 1.78e-07

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 51.74  E-value: 1.78e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  10 ILIADPDPWSRDLLGQLVLGVRcDARLVL-CGDGGEALAHCRRRRFALILAELNLPQVDGFELLReaRLRRSVAEQPFIL 88
Cdd:COG3279   4 ILIVDDEPLARERLERLLEKYP-DLEVVGeASNGEEALELLEEHKPDLVFLDIQMPGLDGFELAR--QLRELDPPPPIIF 80

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 15595464  89 ISdrA-DQASVRaAVALAPTAYLVKPFQAENLMQRLR 124
Cdd:COG3279  81 TT--AyDEYALE-AFEVNAVDYLLKPIDEERLAKALE 114
orf27 CHL00148
Ycf27; Reviewed
 10-127 3.18e-07

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 50.87  E-value: 3.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464   10 ILIADPDPWSRDLLgqlvlgvrcDARLVLCG-------DGGEALAHCRRRRFALILAELNLPQVDGFELLREARLRRSVa 82
Cdd:CHL00148   9 ILVVDDEAYIRKIL---------ETRLSIIGyevitasDGEEALKLFRKEQPDLVILDVMMPKLDGYGVCQEIRKESDV- 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 15595464   83 eqPFILISDRADQASVRAAVALAPTAYLVKPFQAENLMQRLRGLL 127
Cdd:CHL00148  79 --PIIMLTALGDVSDRITGLELGADDYVVKPFSPKELEARIRSVL 121
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 10-124 3.30e-07

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 48.49  E-value: 3.30e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  10 ILIADPDPWSRDLLGQLVLGVRCDARLVL-CGDGGEALAHCRRRRFALILAELNLPQVDGFELLREARLRRSVAEqpFIL 88
Cdd:cd17536   1 VLIVDDEPLIREGLKKLIDWEELGFEVVGeAENGEEALELIEEHKPDIVITDIRMPGMDGLELIEKIRELYPDIK--III 78

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 15595464  89 ISDRADQASVRAAVALAPTAYLVKPFQAENLMQRLR 124
Cdd:cd17536  79 LSGYDDFEYAQKAIRLGVVDYLLKPVDEEELEEALE 114
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 41-119 3.72e-07

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 48.56  E-value: 3.72e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  41 DGGEALAHCRRRRFALILAELNLP-QVDGFELLREARLRRSVaeqPFILISDRADQASVRAAVALAPTAYLVKPFQAENL 119
Cdd:cd17534  33 SGEEAIELAEENKPDLILMDINLKgDMDGIEAAREIREKFDI---PVIFLTAYSDEETLERAKETNPYGYLVKPFNEREL 109
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
 39-127 6.39e-07

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 49.96  E-value: 6.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464   39 CGDGGEALAHCRRRRFALILAELNLPQVDGFELLReaRLRRSVAEQPFILISDRADQasVRAAVALAPTA--YLVKPFQA 116
Cdd:PRK11083  33 FERGLPALDKLRQQPPDLVILDVGLPDISGFELCR--QLLAFHPALPVIFLTARSDE--VDRLVGLEIGAddYVAKPFSP 108

                         90
                 ....*....|.
gi 15595464  117 ENLMQRLRGLL 127
Cdd:PRK11083 109 REVAARVRTIL 119
REC_OmpR_CtrA cd17616
phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is ...
 9-127 1.65e-06

phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is part of the CckA-ChpT-CtrA phosphorelay that is conserved in alphaproteobacteria and is important in orchestrating the cell cycle, polar development, and flagellar biogenesis. CtrA is the master regulator of flagella synthesis genes and also regulates genes involved in the cell cycle, exopolysaccharide synthesis, and cyclic-di-GMP signaling. CtrA is active as a transcription factor when phosphorylated. It is a member of the OmpR family of DNA-binding response regulators, characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381132 [Multi-domain]  Cd Length: 114  Bit Score: 46.63  E-value: 1.65e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464   9 VILIADPDPWSRDLlgQLVL---GVRCDARLVlcgdGGEALAHCRRRRFALILAELNLPQVDGFELLReaRLRRSVAEQP 85
Cdd:cd17616   1 VLLIEDDSATAQSI--ELMLkseGFNVYTTDL----GEEGLDLGKLYDYDIILLDLNLPDMSGYEVLR--TLRLAKVKTP 72

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 15595464  86 FILISDRADQASVRAAVALAPTAYLVKPFQAENLMQRLRGLL 127
Cdd:cd17616  73 ILILSGLADIEDKVKGLGFGADDYMTKPFHKDELVARIHAIV 114
REC_2_GGDEF cd17544
second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This ...
 10-123 2.55e-06

second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins, described in this model, contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381098 [Multi-domain]  Cd Length: 122  Bit Score: 46.36  E-value: 2.55e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  10 ILIADPDPWSRDLLGQLVLgvRCDARLVLCGDGGEALAHCRRRR-FALILAELNLPQVDGFELLREARLRRSVAEQPFIL 88
Cdd:cd17544   3 VLVVDDSATSRNHLRALLR--RHNFQVLEAANGQEALEVLEQHPdIKLVITDYNMPEMDGFELVREIRKKYSRDQLAIIG 80

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 15595464  89 ISDRADQA-SVRAAVALApTAYLVKPFQAENLMQRL 123
Cdd:cd17544  81 ISASGDNAlSARFIKAGA-NDFLTKPFLPEEFYCRV 115
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
 10-127 2.82e-06

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 45.84  E-value: 2.82e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  10 ILIADPDpwsRDLLGQLVLGVRCDARLV-LCGDGGEALAHCRRRRFALILAELNLPQVDGFELLReaRLRRSVAEQPFIL 88
Cdd:cd17627   1 ILVVDDD---RAVRESLRRSLRFEGYEVeTAVDGAEALRVISGNRPDAVVLDVMMPRLDGLEVCR--RLRAAGNDLPILV 75

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 15595464  89 ISDRADQASVRAAVALAPTAYLVKPFQAENLMQRLRGLL 127
Cdd:cd17627  76 LTARDSVSDRVAGLDAGADDYLVKPFALEELLARVRALL 114
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
 41-127 3.02e-06

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 45.88  E-value: 3.02e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  41 DGGEALAHCRRRRFALILAELNLPQVDGFELLREARLRRSVaeqPFILISDRADQASVRAAVALAPTAYLVKPFQAENLM 120
Cdd:cd17614  30 DGREALEKVEEEQPDLILLDLMLPEKDGLEVCREVRKTSNV---PIIMLTAKDSEVDKVLGLELGADDYVTKPFSNRELL 106


                ....*..
gi 15595464 121 QRLRGLL 127
Cdd:cd17614 107 ARVKANL 113
REC_CheC-like cd17593
phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC ...
 33-123 3.38e-06

phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC domain; This subfamily is composed of uncharacterized proteins containing an N-terminal REC domain and a C-terminal CheC domain that may function as the output/effector domain of a response regulator. CheC is a CheY-P phosphatase, affecting the level of phosphorylated CheY which controls the sense of flagella rotation and determine swimming behavior of chemotactic bacteria. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381124 [Multi-domain]  Cd Length: 117  Bit Score: 45.61  E-value: 3.38e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  33 DARLVLCGDGGEALAHCRRRRFALILAELNLPQVDGFELLreARLRRSVAEQPFILISDRADQASVRAAVALAPTAYLVK 112
Cdd:cd17593  25 DVEITFAENGEEALEILREGRIDVLFLDLTMPVMDGYEVL--EALPVEQLETKVIVVSGDVQPEAKERVLELGALAFLKK 102

                        90
                ....*....|.
gi 15595464 113 PFQAENLMQRL 123
Cdd:cd17593 103 PFDPEKLAQLL 113
REC_OmpR_BfmR-like cd19939
phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; ...
 40-127 3.69e-06

phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; Acinetobacter baumannii BfmR is part of the BfmR/S two-component system that functions as the master regulator of biofilm initiation. BfmR confers resistance to complement-mediated bactericidal activity, independent of capsular polysaccharide, and also increases resistance to the clinically important antimicrobials meropenem and colistin, making it a potential antimicrobial target. Its inhibition would have the dual benefit of significantly decreasing in vivo survival and increasing sensitivity to selected antimicrobials. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381166 [Multi-domain]  Cd Length: 116  Bit Score: 45.44  E-value: 3.69e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  40 GDGGEALAHCRRRRFALILAELNLPQVDGFELLREARLRRSvaeQPFILISDRADQASVRAAVALAPTAYLVKPFQAENL 119
Cdd:cd19939  30 TDGQRAVRRIIDEQPSLVVLDIMLPGMDGLTVCREVREHSH---VPILMLTARTEEMDRVLGLEMGADDYLCKPFSPREL 106


                ....*...
gi 15595464 120 MQRLRGLL 127
Cdd:cd19939 107 LARVRALL 114
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
 40-120 3.78e-06

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 45.57  E-value: 3.78e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  40 GDGGEALAHCRRRRFALILAELNLPQVDGFELLREarLRRSVAEQPFILISDRADQASVRAAVALAPTAYLVKPFQAENL 119
Cdd:cd17550  29 ADGEEALKLIKERRPDLVLLDIWLPDMDGLELLKE--IKEKYPDLPVIMISGHGTIETAVKATKLGAYDFIEKPLSLDRL 106


                .
gi 15595464 120 M 120
Cdd:cd17550 107 L 107
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
 10-127 4.51e-06

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 45.37  E-value: 4.51e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  10 ILIADPDPWSRDLLGQLVLG----VRCdarlvlCGDGGEALAHCRRRRFALILAELNLPQVDGFELLREARLRRSVaeqP 85
Cdd:cd17623   1 ILLIDDDRELTELLTEYLEMegfnVRA------AHDGEQGLAALLEGSPDLVVLDVMLPKMNGLDVLKELRKTSQV---P 71

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 15595464  86 FILISDRADQASVRAAVALAPTAYLVKPFQAENLMQRLRGLL 127
Cdd:cd17623  72 VLMLTARGDDIDRILGLELGADDYLPKPFNPRELVARIRAIL 113
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
 39-127 5.05e-06

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 45.17  E-value: 5.05e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  39 CGDGGEALAHCRRRRFALILAELNLPQVDGFELLReaRLRRSVAEQPFILISDRADQASVRAAVALAPTAYLVKPFQAEN 118
Cdd:cd17624  28 VRTGAEAEAALASGPYDLVILDLGLPDGDGLDLLR--RWRRQGQSLPVLILTARDGVDDRVAGLDAGADDYLVKPFALEE 105


                ....*....
gi 15595464 119 LMQRLRGLL 127
Cdd:cd17624 106 LLARLRALL 114
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
 10-121 5.22e-06

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 45.14  E-value: 5.22e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  10 ILIADPDPWSRDLLGQLV--LGvrcdARLVLCGDGGEALAHCRRRRFALILAELNLPQVDGFELLREARLRRSVAEQPFI 87
Cdd:cd17580   1 ILVVDDNEDAAEMLALLLelEG----AEVTTAHSGEEALEAAQRFRPDVILSDIGMPGMDGYELARRLRELPWLANTPAI 76

                        90       100       110
                ....*....|....*....|....*....|....
gi 15595464  88 LISDRADQASVRAAVALAPTAYLVKPFQAENLMQ 121
Cdd:cd17580  77 ALTGYGQPEDRERALEAGFDAHLVKPVDPDELIE 110
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 1-124 5.40e-06

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 46.95  E-value: 5.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464    1 MSAAKKAPVILIaDPDPWSRDLLGQLVlgvRCDARLVLCG---DGGEALAHCRRRRFALILAELNLPQVDGFELLREARL 77
Cdd:PRK10651   1 MSNQEPATILLI-DDHPMLRTGVKQLI---SMAPDITVVGeasNGEQGIELAESLDPDLILLDLNMPGMNGLETLDKLRE 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 15595464   78 RRSVAEQPFILISDRADqaSVRAAVALAPTAYLVKPFQAENLMQRLR 124
Cdd:PRK10651  77 KSLSGRIVVFSVSNHEE--DVVTALKRGADGYLLKDMEPEDLLKALQ 121
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 10-119 6.19e-06

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 45.10  E-value: 6.19e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  10 ILIADPDPWSR----DLL---GQLVLGVrcdarlvlCGDGGEALAHCRRRRFALILAELNLPQVDGFELLREARLRRSVa 82
Cdd:cd19932   3 VLIAEDEALIRmdlrEMLeeaGYEVVGE--------ASDGEEAVELAKKHKPDLVIMDVKMPRLDGIEAAKIITSENIA- 73

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 15595464  83 eqPFILISDRADQASVRAAVALAPTAYLVKPFQAENL 119
Cdd:cd19932  74 --PIVLLTAYSQQDLVERAKEAGAMAYLVKPFSESDL 108
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
 41-124 6.95e-06

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 44.74  E-value: 6.95e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  41 DGGEALAHCRRRRFALILAELNLPQVDGFELLREARLRRSVaeqPFILIS-DRADQASVRAAVALAPTAYLVKPFQAENL 119
Cdd:cd17594  31 DGAEEARLMLHRRVDLVLLDLRLGQESGLDLLRTIRARSDV---PIIIISgDRRDEIDRVVGLELGADDYLAKPFGLREL 107


                ....*
gi 15595464 120 MQRLR 124
Cdd:cd17594 108 LARVR 112
PRK15479 PRK15479
transcriptional regulator TctD;
40-130 9.44e-06

transcriptional regulator TctD;


Pssm-ID: 185376 [Multi-domain]  Cd Length: 221  Bit Score: 46.25  E-value: 9.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464   40 GDGGEALAHCRRRRFALILAELNLPQVDGFELLreARLRRSVAEQPFILISDRADQASVRAAVALAPTAYLVKPFQAENL 119
Cdd:PRK15479  31 FDGLAADHLLQSEMYALAVLDINMPGMDGLEVL--QRLRKRGQTLPVLLLTARSAVADRVKGLNVGADDYLPKPFELEEL 108

                         90
                 ....*....|.
gi 15595464  120 MQRLRGLLLKG 130
Cdd:PRK15479 109 DARLRALLRRS 119
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 10-127 1.20e-05

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 44.19  E-value: 1.20e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  10 ILIADPDPWSRDLLGQL-------VLGvrcDArlvlcGDGGEALAHCRRRRFALILAELNLPQVDGFELLREARLRRSVA 82
Cdd:cd17542   3 VLIVDDAAFMRMMLKDIltkagyeVVG---EA-----ANGEEAVEKYKELKPDLVTMDITMPEMDGIEALKEIKKIDPNA 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 15595464  83 EqpFILISDRADQASVRAAVALAPTAYLVKPFQAENLMQRLRGLL 127
Cdd:cd17542  75 K--VIMCSAMGQEEMVKEAIKAGAKDFIVKPFQPERVLEAVEKVL 117
REC_OmpR_NsrR-like cd18159
phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family ...
 56-127 2.45e-05

phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family response regulators; Streptococcus agalactiae NsrR is a lantibiotic resistance-associated response regulator and is part of the nisin resistance operon. It is a member of the NsrRK two-component system (TCS) that is involved in the regulation of lantibiotic resistance genes such as a membrane-associated lipoprotein of LanI, and the nsr gene cluster which encodes for the resistance protein NSR and the ABC transporter NsrFP, both conferring resistance against nisin. This subfamily also includes Staphylococcus epidermidis GraR, part of the GraR/GraS TCS involved in resistance against cationic antimicrobial peptides, and Bacillus subtilis BceR, part of the BceS/BceR TCS involved in the regulation of bacitracin resistance. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381143 [Multi-domain]  Cd Length: 113  Bit Score: 43.04  E-value: 2.45e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15595464  56 LILAELNLPQVDGFELLREARLRRSVaeqPFILISDRADQASVRAAVALAPTAYLVKPFQAENLMQRLRGLL 127
Cdd:cd18159  45 LVLLDINLPYFDGFYWCREIRQISNV---PIIFISSRDDNMDQVMAINMGGDDYITKPFDLDVLLAKIKAIL 113
REC_WspR-like cd17575
phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The ...
 39-124 2.46e-05

phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The GGDEF response regulator WspR is part of the Wsp system that is homologous to chemotaxis systems and also includes the membrane-bound receptor protein WspA. In response to growth on surfaces, WspR is phosphorylated by the Wsp signal transduction complex and is activated, functioning as a diguanylate cyclase (DGC) that catalyzes c-di-GMP synthesis. WspR is a hybrid response regulator-diguanylate cyclase, containing an N-terminal REC domain and a C-terminal GGDEF domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381117 [Multi-domain]  Cd Length: 128  Bit Score: 43.55  E-value: 2.46e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  39 CGDGGEALAHCRRRRFALILAELNLPQVDGFELLREARLRRSVAEQPFILISDRADQASVRAAVALAPTAYLVKPFQAEN 118
Cdd:cd17575  31 CSDPTEAIEVASQIKPTVILQDLVMPGVDGLTLVRFFRANPATRDIPIIVLSTKEEPEVKSEAFALGANDYLVKLPDKIE 110


                ....*.
gi 15595464 119 LMQRLR 124
Cdd:cd17575 111 LVARIR 116
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
 33-124 3.77e-05

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 42.96  E-value: 3.77e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  33 DARLVLCGDGGEALAHCRRRRFALILAELNLPQVDGFELLReaRLRRSVAEQPFILISdraDQASVRAAVA---LAPTAY 109
Cdd:cd17572  22 GYKVTHVETGKEALAFLSDQPPDVVLLDLKLPDMSGMEILK--WIQERSLPTSVIVIT---AHGSVDIAVEamrLGAYDF 96

                        90
                ....*....|....*
gi 15595464 110 LVKPFQAENLMQRLR 124
Cdd:cd17572  97 LEKPFDADRLRVTVR 111
REC_OmpR_BaeR-like cd19938
phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is ...
 41-127 5.17e-05

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381165 [Multi-domain]  Cd Length: 114  Bit Score: 42.37  E-value: 5.17e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  41 DGGEALAHCRRRRFALILAELNLPQVDGFELLREARLRRSVaeqPFILISDRADQASVRAAVALAPTAYLVKPFQAENLM 120
Cdd:cd19938  31 HGDQVLPYVRHTPPDLILLDLMLPGTDGLTLCREIRRFSDV---PIIMVTARVEEIDRLLGLELGADDYICKPYSPREVV 107


                ....*..
gi 15595464 121 QRLRGLL 127
Cdd:cd19938 108 ARVKAIL 114
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 10-74 6.48e-05

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 42.19  E-value: 6.48e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15595464  10 ILIADPDPWSRDLLGQLvLGVRCDARLVL-CGDGGEALAHCRRRRFALILAELNLPQVDGFELLRE 74
Cdd:COG2197   4 VLIVDDHPLVREGLRAL-LEAEPDIEVVGeAADGEEALELLEELRPDVVLLDIRMPGMDGLEALRR 68
REC_OmpR_EcPhoP-like cd19934
phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; ...
 9-127 7.62e-05

phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; Escherichia coli PhoP (EcPhoP) is part of the PhoQ/PhoP two-component system (TCS) that regulates virulence genes and plays an essential role in the response of the bacteria to the environment of their mammalian hosts, sensing several stimuli such as extracellular magnesium limitation, low pH, the presence of cationic antimicrobial peptides, and osmotic upshift. This subfamily also includes Brucella suis FeuP, part of the FeuPQ TCS that is involved in the regulation of iron uptake, and Microchaete diplosiphon RcaC, which is required for chromatic adaptation. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381161 [Multi-domain]  Cd Length: 117  Bit Score: 41.88  E-value: 7.62e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464   9 VILIADPDPWSRDLLGQLV-LGVRCDARLvlcgDGGEALAHCRRRRFALILAELNLPQVDGFELLReaRLRRSVAEQPFI 87
Cdd:cd19934   1 LLLVEDDALLAAQLKEQLSdAGYVVDVAE----DGEEALFQGEEEPYDLVVLDLGLPGMDGLSVLR--RWRSEGRATPVL 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 15595464  88 LISDRADQASVRAAVALAPTAYLVKPFQAENLMQRLRGLL 127
Cdd:cd19934  75 ILTARDSWQDKVEGLDAGADDYLTKPFHIEELLARLRALI 114
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
10-80 1.06e-04

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 44.73  E-value: 1.06e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15595464    10 ILIADPDPWSRDLLG-QL-VLGVRCDArlvlCGDGGEALAHCRRRRFALILAELNLPQVDGFELLREARLRRS 80
Cdd:PRK09959  961 ILIADDHPTNRLLLKrQLnLLGYDVDE----ATDGVQALHKVSMQHYDLLITDVNMPNMDGFELTRKLREQNS 1029
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
 10-126 1.07e-04

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 41.44  E-value: 1.07e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  10 ILIADPDPWSRDLL-------GQLVlgvrcdarlVLCGDGGEALAHCRRRRFALILAELNLPQVDGFELLREARLRRSva 82
Cdd:cd17554   3 ILVVDDEENIRELYkeeledeGYEV---------VTAGNGEEALEKLESEDPDLVILDIKMPGMDGLETLRKIREKKP-- 71

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 15595464  83 EQPFILI---SDRADQASVRAAvalapTAYLVKPFQAENLMQRLRGL 126
Cdd:cd17554  72 DLPVIICtaySEYKSDFSSWAA-----DAYVVKSSDLTELKETIKRL 113
REC_OmpR_KdpE-like cd17620
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ...
 10-113 1.64e-04

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381135 [Multi-domain]  Cd Length: 99  Bit Score: 40.23  E-value: 1.64e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  10 ILIADPDPWSRDLLgQLVLGVrCDARLVLCGDGGEALAHCRRRRFALILAELNLPQVDGFELLREARLRRSVaeqPFILI 89
Cdd:cd17620   1 ILVIEDEPQIRRFL-RTALEA-HGYRVFEAETGQEGLLEAATRKPDLIILDLGLPDMDGLEVIRRLREWSAV---PVIVL 75

                        90       100
                ....*....|....*....|....
gi 15595464  90 SDRADQASVRAAVALAPTAYLVKP 113
Cdd:cd17620  76 SARDEESDKIAALDAGADDYLTKP 99
REC_HupR-like cd17569
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar ...
 8-124 1.73e-04

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar domains; This family is composed of mostly uncharacterized response regulators with similarity to the REC domains of response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It contains an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. Members of this family contain a REC domain and various output domains including the cyclase homology domain (CHD) and the c-di-GMP phosphodiesterase domains, HD-GYP and EAL. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381113 [Multi-domain]  Cd Length: 118  Bit Score: 40.85  E-value: 1.73e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464   8 PVILIADPDPWSRDLLGQLVLgvRCDARLVLCGDGGEALAHCRRRRFALILAELNLPQVDGFELLREARlrrsvAEQPF- 86
Cdd:cd17569   1 PTILLVDDEPNILKALKRLLR--REGYEVLTATSGEEALEILKQEPVDVVISDQRMPGMDGAELLKRVR-----ERYPDt 73

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 15595464  87 --ILISDRADQASVRAAVALAPT-AYLVKPFQAENLMQRLR 124
Cdd:cd17569  74 vrILLTGYADLDAAIEAINEGEIyRFLTKPWDDEELKETIR 114
PRK10529 PRK10529
DNA-binding transcriptional activator KdpE; Provisional
 52-124 1.85e-04

DNA-binding transcriptional activator KdpE; Provisional


Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 42.48  E-value: 1.85e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15595464   52 RRFALILAELNLPQVDGFELLREARLRRSVaeqPFILISDRADQASVRAAVALAPTAYLVKPFQAENLMQRLR 124
Cdd:PRK10529  44 RKPDLIILDLGLPDGDGIEFIRDLRQWSAI---PVIVLSARSEESDKIAALDAGADDYLSKPFGIGELQARLR 113
PRK09836 PRK09836
DNA-binding transcriptional activator CusR; Provisional
 54-135 2.23e-04

DNA-binding transcriptional activator CusR; Provisional


Pssm-ID: 182102 [Multi-domain]  Cd Length: 227  Bit Score: 42.22  E-value: 2.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464   54 FALILAELNLPQVDGFELLReaRLRRSVAEQPFILISDRADQASVRAAVALAPTAYLVKPFQAENLMQRLRGLLLKGDEV 133
Cdd:PRK09836  45 YDLIILDIMLPDVNGWDIVR--MLRSANKGMPILLLTALGTIEHRVKGLELGADDYLVKPFAFAELLARVRTLLRRGAAV 122


                 ..
gi 15595464  134 VA 135
Cdd:PRK09836 123 II 124
psREC_PRR cd17582
pseudo receiver domain of pseudo-response regulators; In Arabidopsis, five pseudo-response ...
 10-113 3.07e-04

pseudo receiver domain of pseudo-response regulators; In Arabidopsis, five pseudo-response regulators (PRRs), also called APRRs, comprise a core group of clock components that controls the pace of the central oscillator of the circadian clock, an endogenous time-keeping mechanism that enables organisms to adapt to external daily cycles. The coordinated sequential expression of PRR9 (APRR9), PRR7 (APRR7), PRR5 (APRR5), PRR3 (APRR3), and PRR1 (APRR1) results in circadian waves that may be at the basis of the endogenous circadian clock. PRRs contain an N-terminal pseudo receiver (psREC) domain that resembles the receiver domain of a two-component response regulator, but lacks an aspartate residue that accepts a phosphoryl group from the sensor kinase, and a CCT motif at the C-terminus that contains a putative nuclear localization signal. The psREC domain is involved in protein-protein interactions.


Pssm-ID: 381120 [Multi-domain]  Cd Length: 104  Bit Score: 39.69  E-value: 3.07e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  10 ILIADPDPWSRDLLGQLVLgvRCDARLVLCGDGGEA--LAHCRRRRFALILAELNLPQVDGFELLREARLRRSVAEQPFI 87
Cdd:cd17582   1 VLLVENDDSTRQIVTALLR--KCSYEVTAASDGLQAwdVLEDEQNEIDLILTEVDLPVSSGFKLLSYIMRHKICKNIPVI 78

                        90       100
                ....*....|....*....|....*.
gi 15595464  88 LISDRADQASVRAAVALAPTAYLVKP 113
Cdd:cd17582  79 MMSSQDSVGVVFKCLSKGAADYLVKP 104
REC_DivK-like cd17548
phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus ...
 9-76 4.31e-04

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381100 [Multi-domain]  Cd Length: 115  Bit Score: 39.45  E-value: 4.31e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15595464   9 VILIADPDPWSRDLLGQLVLGVRCdaRLVLCGDGGEALAHCRRRRFALILAELNLPQVDGFELLREAR 76
Cdd:cd17548   1 KILIVEDNPLNMKLARDLLESAGY--EVLEAADGEEALEIARKEKPDLILMDIQLPGMDGLEATRLLK 66
PRK10766 PRK10766
two-component system response regulator TorR;
56-127 5.31e-04

two-component system response regulator TorR;


Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 41.18  E-value: 5.31e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15595464   56 LILAELNLPQVDGFELLREARLRRSVAeqpFILISDRADqaSVRAAVALAPTA--YLVKPFQAENLMQRLRGLL 127
Cdd:PRK10766  49 LILLDINLPGEDGLMLTRELRSRSTVG---IILVTGRTD--SIDRIVGLEMGAddYVTKPLELRELLVRVKNLL 117
PRK10365 PRK10365
sigma-54-dependent response regulator transcription factor ZraR;
10-137 5.65e-04

sigma-54-dependent response regulator transcription factor ZraR;


Pssm-ID: 182412 [Multi-domain]  Cd Length: 441  Bit Score: 41.94  E-value: 5.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464   10 ILIADPDPWSRDLLGQLVLGvrCDARLVLCGDGGEALAHCRRRRFALILAELNLPQVDGFELLREARlrrsvAEQPFILI 89
Cdd:PRK10365   8 ILVVDDDISHCTILQALLRG--WGYNVALANSGRQALEQVREQVFDLVLCDVRMAEMDGIATLKEIK-----ALNPAIPV 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 15595464   90 SDRADQASVRAAV-ALAPTA--YLVKPFQAENLMQRLRGLLLKGDEVVACP 137
Cdd:PRK10365  81 LIMTAYSSVETAVeALKTGAldYLIKPLDFDNLQATLEKALAHTHSIDAET 131
PRK10643 PRK10643
two-component system response regulator PmrA;
40-127 5.87e-04

two-component system response regulator PmrA;


Pssm-ID: 182612 [Multi-domain]  Cd Length: 222  Bit Score: 40.79  E-value: 5.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464   40 GDGGEALAHCRRRRFALILAELNLPQVDGFELLReaRLRRSVAEQP-FIL-----ISDRADQASVRAavalapTAYLVKP 113
Cdd:PRK10643  31 STAREAEALLESGHYSLVVLDLGLPDEDGLHLLR--RWRQKKYTLPvLILtardtLEDRVAGLDVGA------DDYLVKP 102

                         90
                 ....*....|....
gi 15595464  114 FQAENLMQRLRGLL 127
Cdd:PRK10643 103 FALEELHARIRALI 116
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 10-127 6.24e-04

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 39.15  E-value: 6.24e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  10 ILIADPDPWSRDLLgQLVLgVRCDARLVLCGDGGEALAHCRRRRFALILAELNLPQVDGFELLREARLRRSVAEQPFILI 89
Cdd:cd17618   3 ILIVEDEPAIREMI-AFNL-ERAGFDVVEAEDAESAVNLIVEPRPDLILLDWMLPGGSGIQFIRRLKRDEMTRDIPIIML 80

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 15595464  90 SDRADQASVRAAVALAPTAYLVKPFQAENLMQRLRGLL 127
Cdd:cd17618  81 TARGEEEDKVRGLEAGADDYITKPFSPRELVARIKAVL 118
REC_PA4781-like cd19920
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar ...
 10-114 6.65e-04

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains; Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381147 [Multi-domain]  Cd Length: 103  Bit Score: 38.65  E-value: 6.65e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  10 ILIADPDPWSRDLLGQLVLGVRCDARLVLcgDGGEALAHCRRRRFALILAELNLPQVDGFELLReaRLRR--SVAEQPFI 87
Cdd:cd19920   1 ILIVDDVPDNLRLLSELLRAAGYRVLVAT--DGQQALQRAQAEPPDLILLDVMMPGMDGFEVCR--RLKAdpATRHIPVI 76

                        90       100
                ....*....|....*....|....*..
gi 15595464  88 LISDRADQASVRAAVALAPTAYLVKPF 114
Cdd:cd19920  77 FLTALTDTEDKVKGFELGAVDYITKPF 103
PRK11517 PRK11517
DNA-binding response regulator HprR;
41-127 1.03e-03

DNA-binding response regulator HprR;


Pssm-ID: 183172 [Multi-domain]  Cd Length: 223  Bit Score: 40.27  E-value: 1.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464   41 DGGEALAHCRRRRFALILAELNLPQVDGFELLREArlrRSVAEQPFILISDRADQASVRAAVALAPTAYLVKPFQAENLM 120
Cdd:PRK11517  32 DGRDGLYLALKDDYALIILDIMLPGMDGWQILQTL---RTAKQTPVICLTARDSVDDRVRGLDSGANDYLVKPFSFSELL 108


                 ....*..
gi 15595464  121 QRLRGLL 127
Cdd:PRK11517 109 ARVRAQL 115
REC_CheV-like cd19924
phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This ...
 10-113 1.22e-03

phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This subfamily includes the REC domains of Bacillus subtilis chemotaxis protein CheV, Myxococcus xanthus gliding motility regulatory protein FrzE, and similar proteins. CheV is a hybrid protein with an N-terminal CheW-like domain and a C-terminal CheY-like REC domain. The CheV pathway is one of three systems employed by B. subtilis for sensory adaptation that contribute to chemotaxis. It is involved in the transmission of sensory signals from chemoreceptors to flagellar motors. Together with CheW, it is involved in the coupling of methyl-accepting chemoreceptors to the central two-component histidine kinase CheA. FrzE is a hybrid sensor histidine kinase/response regulator that is part of the Frz pathway that controls cell reversal frequency to support directional motility during swarming and fruiting body formation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381151 [Multi-domain]  Cd Length: 111  Bit Score: 38.13  E-value: 1.22e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  10 ILIADPDPWSRDLLGQLVLGVRCDarLVLCGDGGEAL---------AHCRRRRFALILAELNLPQVDGFELLREARLRRS 80
Cdd:cd19924   1 ILVVDDSPTARKQLRDLLKNLGFE--IAEAVDGEEALnklenlakeGNDLSKELDLIITDIEMPKMDGYELTFELRDDPR 78

                        90       100       110
                ....*....|....*....|....*....|...
gi 15595464  81 VAEQPFILISDRADQASVRAAVALAPTAYLVKP 113
Cdd:cd19924  79 LANIPVILNSSLSGEFSRARGKKVGADAYLAKF 111
PRK10430 PRK10430
two-component system response regulator DcuR;
56-129 1.33e-03

two-component system response regulator DcuR;


Pssm-ID: 182454 [Multi-domain]  Cd Length: 239  Bit Score: 40.09  E-value: 1.33e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15595464   56 LILAELNLPQVDGFELL---REARLRRSVaeqpfILISDRADQASVRAAVALAPTAYLVKPFQAENLMQRLRGLLLK 129
Cdd:PRK10430  52 LILLDIYMQQENGLDLLpvlHEAGCKSDV-----IVISSAADAATIKDSLHYGVVDYLIKPFQASRFEEALTGWRQK 123
ompR PRK09468
osmolarity response regulator; Provisional
 10-127 1.67e-03

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 39.57  E-value: 1.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464   10 ILIADPDPWSRDLLGQLVLGVRCDARLVLCGDGGEALAHcrRRRFALILAELNLPQVDGFELLReaRLRRSVAEQPFILI 89
Cdd:PRK09468   8 ILVVDDDMRLRALLERYLTEQGFQVRSAANAEQMDRLLT--RESFHLMVLDLMLPGEDGLSICR--RLRSQNNPTPIIML 83

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 15595464   90 SDRADQASVRAAVALAPTAYLVKPFQAENLMQRLRGLL 127
Cdd:PRK09468  84 TAKGEEVDRIVGLEIGADDYLPKPFNPRELLARIRAVL 121
REC_HupR cd17596
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of ...
 8-127 2.32e-03

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of this subfamily are response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It belongs to the nitrogen regulatory protein C (NtrC) family of response regulators, which activate transcription by RNA polymerase (RNAP) in response to a change in the environment. HupR is an unusual member of this family as it activates transcription when unphosphorylated, and transcription is inhibited by phosphorylation. Proteins in this subfamily contain an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381127 [Multi-domain]  Cd Length: 133  Bit Score: 38.12  E-value: 2.32e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464   8 PVILIADPDPWSRDLLGQLVlgvRCDARLVLCGDGGEALAHCRRRRFALILAELNLPQVDGFELLREARLRRsvAEQPFI 87
Cdd:cd17596   1 PTILVVDDEVRSLEALRRTL---EEDFDVLTAASAEEALAILEEEWVQVILCDQRMPGTTGVEFLKEVRERW--PEVVRI 75

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 15595464  88 LISDRADQASVRAAVALAPT-AYLVKPFQAENLMQRLRGLL 127
Cdd:cd17596  76 IISGYTDSEDIIAGINEAGIyQYLTKPWHPDQLLLTVRNAA 116
REC_OmpR_RegX3-like cd17621
phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is ...
 41-113 2.81e-03

phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is a member of the SenX3-RegX3 two-component system that is involved in phosphate-sensing signal transduction. Phosphorylated RegX3 functions as a transcriptional activator of phoA. It induces transcription in phosphate limiting environment and also controls expression of several critical metabolic enzymes in aerobic condition. RegX3 belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381136 [Multi-domain]  Cd Length: 99  Bit Score: 36.79  E-value: 2.81e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15595464  41 DGGEALAHCRRRRFALILAELNLPQVDGFELLREARLRRSVaeqPFILISDRADQASVRAAVALAPTAYLVKP 113
Cdd:cd17621  30 DGPAALAEFDRAGADIVLLDLMLPGLSGTEVCRQLRARSNV---PVIMVTAKDSEIDKVVGLELGADDYVTKP 99
REC_CpdR_CckA-like cd18160
phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; ...
 54-114 3.01e-03

phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; Two-component systems (TCSs), consisting of a sensor and a response regulator, are used by bacteria to adapt to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis and membrane transport. Response regulators share the common phosphoacceptor REC domain and differ output domains such as DNA, RNA, ligand, and protein-binding, or enzymatic domain. CpdR is a stand-alone REC protein. CckA is a sensor histidine kinase containing N-terminal PAS domains and a C-terminal REC domain. CpdR and CckA are components of a regulatory phosphorelay system (composed of CckA, ChpT, CtrA and CpdR) that controls Brucella abortus cell growth, division, and intracellular survival inside mammalian host cells. CckA autophosphorylates in the presence of ATP and transfers a phosphoryl group to the conserved aspartic acid residue on its C-terminal REC domain, which is relayed to the ChpT phosphotransferase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381144 [Multi-domain]  Cd Length: 103  Bit Score: 37.10  E-value: 3.01e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15595464  54 FALILAELNLPQVDGFELLREArlRRSVAEQPFILISDRADQASVRAAVALAPTAYLVKPF 114
Cdd:cd18160  45 IDIVVTDIVMPEMDGIELAREA--RKIDPDVKILFISGGAAAAPELLSDAVGDNATLKKPF 103
PRK10710 PRK10710
DNA-binding transcriptional regulator BaeR; Provisional
 1-127 3.13e-03

DNA-binding transcriptional regulator BaeR; Provisional


Pssm-ID: 182665 [Multi-domain]  Cd Length: 240  Bit Score: 38.90  E-value: 3.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464    1 MSAAKKAPVILIADPDPwsrdLLGQLVLGV--RCDARLVLCGDGGEALAHCRRRRFALILAELNLPQVDGFELLREarLR 78
Cdd:PRK10710   4 LPIDENTPRILIVEDEP----KLGQLLIDYlqAASYATTLLSHGDEVLPYVRQTPPDLILLDLMLPGTDGLTLCRE--IR 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 15595464   79 RsVAEQPFILISDRADQASVRAAVALAPTAYLVKPFQAENLMQRLRGLL 127
Cdd:PRK10710  78 R-FSDIPIVMVTAKIEEIDRLLGLEIGADDYICKPYSPREVVARVKTIL 125
REC_PatA-like cd17602
phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) ...
 35-113 3.33e-03

phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) PatA is necessary for proper patterning of heterocysts along filaments. PatA contains phosphoacceptor REC domain at its C-terminus and an N-terminal PATAN (PatA N-terminus) domain, which was proposed in a bioinformatics study to mediate protein-protein interactions. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members of this group may have an inactive REC domain, lacking canonical metal-binding and active site residues.


Pssm-ID: 381129 [Multi-domain]  Cd Length: 102  Bit Score: 36.96  E-value: 3.33e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  35 RLVLCGDGGEALAHCRRRRFALILAELNLPQVDGFELLREARLRRSVAEQPFILISDRA---DQASVRAAVAlapTAYLV 111
Cdd:cd17602  24 RVVVIDDPLRALTTLLNSKPDLILIDIDMPDLDGYELCSLLRKSSALKDTPIIMLTGKDglvDRIRAKMAGA---SGYLT 100


                ..
gi 15595464 112 KP 113
Cdd:cd17602 101 KP 102
REC_OmpR_kpRstA-like cd17622
phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; ...
 41-127 3.83e-03

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381137 [Multi-domain]  Cd Length: 116  Bit Score: 36.97  E-value: 3.83e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  41 DGGEALAHCRRRRFALILAELNLPQVDGFELLREArlrRSVAEQPFILISDRADQASVRAAVALAPTAYLVKPFQAENLM 120
Cdd:cd17622  32 RGDRALEVIAREKPDAVLLDIMLPGIDGLTLCRDL---RPKYQGPILLLTALDSDIDHILGLELGADDYVVKPVEPAVLL 108


                ....*..
gi 15595464 121 QRLRGLL 127
Cdd:cd17622 109 ARLRALL 115
REC_Ycf29 cd19927
phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a ...
 10-113 3.94e-03

phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a probable response regulator of a two-component system (TCS), typically consisting a sensor and a response regulator, that functions in adaptation to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Ycf29 contains an N-terminal REC domain and a LuxR-type helix-turn-helix DNA-binding output domain. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381154 [Multi-domain]  Cd Length: 102  Bit Score: 36.59  E-value: 3.94e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  10 ILIADPDPWSRDLLGQLVLGVRCDARLVLCGDggEALAHCRRRRFALILAELNLPQVDGFELLREARLRRSVAEQPFILI 89
Cdd:cd19927   1 ILLVDDDPGIRLAVKDYLEDQGFTVIAASNGL--EALDLLNQYIPDLIISDIIMPGVDGYSLLGKLRKNADFDTIPVIFL 78

                        90       100
                ....*....|....*....|....
gi 15595464  90 SDRADQASVRAAVALAPTAYLVKP 113
Cdd:cd19927  79 TAKGMTSDRIKGYNAGCDGYLSKP 102
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
 37-123 4.63e-03

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 36.65  E-value: 4.63e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  37 VLCGDGGEALAHCRRRRFALILAELNLPQVDGFELLReaRLRRSVAEQPFILISDRADQASVRAAVALAPTAYLVKPFQA 116
Cdd:cd17563  28 ETAHSVEEALALAREEKPDYAVLDLRLGGDSGLDLIP--PLRALQPDARIVVLTGYASIATAVEAIKLGADDYLAKPADA 105


                ....*..
gi 15595464 117 ENLMQRL 123
Cdd:cd17563 106 DEILAAL 112
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 10-124 4.83e-03

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 36.75  E-value: 4.83e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  10 ILIADPDPWSRDLLGQLvLGVRCDARLV-LCGDGGEALAHCRRRRFALILAELNLPQVDGFELlreARLRRSVAEQPFIL 88
Cdd:cd17532   1 ALIVDDEPLAREELRYL-LEEHPDIEIVgEAENGEEALEAIEELKPDVVFLDIQMPGLDGLEL---AKKLSKLAKPPLIV 76

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 15595464  89 ISDRADQASVRaAVALAPTAYLVKPFQAENL---MQRLR 124
Cdd:cd17532  77 FVTAYDEYAVE-AFELNAVDYLLKPFSEERLaeaLAKLR 114
PRK13856 PRK13856
two-component response regulator VirG; Provisional
 56-124 8.99e-03

two-component response regulator VirG; Provisional


Pssm-ID: 172377 [Multi-domain]  Cd Length: 241  Bit Score: 37.49  E-value: 8.99e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464   56 LILAELNLPQVDGFELLREARLRRSVaeqPFILIS-DRADQASVRAAVALAPTAYLVKPFQAENLMQRLR 124
Cdd:PRK13856  48 VVVVDLNLGREDGLEIVRSLATKSDV---PIIIISgDRLEEADKVVALELGATDFIAKPFGTREFLARIR 114
REC_RR468-like cd17552
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and ...
 10-127 9.07e-03

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and similar domains; Thermotoga maritima RR468 (encoded by gene TM0468) is the cognate response regulator (RR) of the class I histidine kinase HK853 (product of gene TM0853). HK853/RR468 comprise a two-component system (TCS) that couples environmental stimuli to adaptive responses. This subfamily also includes Fremyella diplosiphon complementary adaptation response regulator homolog RcaF, a small RR that is involved in four-step phosphorelays of the complementary chromatic adaptation (CCA) system that occurs in many cyanobacteria. Both RR468 and RcaF are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381104 [Multi-domain]  Cd Length: 121  Bit Score: 35.99  E-value: 9.07e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464  10 ILIADPDPWSRDLLgQLVLGVRCDARLVLCGDGGEALAHCRRRRFALILAELNLPQVDGFELLReaRLRRSVAEQ--PFI 87
Cdd:cd17552   4 ILVIDDEEDIREVV-QACLEKLAGWEVLTASSGQEGLEKAATEQPDAILLDVMMPDMDGLATLK--KLQANPETQsiPVI 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 15595464  88 LISDRADQASVRAAVALAPTAYLVKPFQAENLMQRLRGLL 127
Cdd:cd17552  81 LLTAKAQPSDRQRFASLGVAGVIAKPFDPLTLAEQIAKLL 120
PRK15347 PRK15347
two component system sensor kinase;
41-123 9.19e-03

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 38.47  E-value: 9.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15595464   41 DGGEALAHCRRRRFALILAELNLPQVDGFELLReaRLRRSVA----EQPFILIS--------DRADQASVRaavalaptA 108
Cdd:PRK15347 722 SGTEALELGRQHRFDLVLMDIRMPGLDGLETTQ--LWRDDPNnldpDCMIVALTanaapeeiHRCKKAGMN--------H 791

                         90
                 ....*....|....*
gi 15595464  109 YLVKPFQAENLMQRL 123
Cdd:PRK15347 792 YLTKPVTLAQLARAL 806
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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