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Conserved domains on  [gi|1554490347|gb|QAA51461|]
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hypothetical protein C1O47_11655 [Akkermansia muciniphila]

Protein Classification

glycosyltransferase family 4 protein( domain architecture ID 10133453)

glycosyltransferase family 4 (GT4) protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds

CAZY:  GT4
EC:  2.4.-.-
Gene Ontology:  GO:0016757|GO:0006486
PubMed:  12691742|10521532|16037492
SCOP:  3001586

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 4-296 2.72e-22

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


:

Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 96.84  E-value: 2.72e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1554490347   4 KFLFWQNMISIHQTALLNALASK-HQVTLAVQRAFEEERTDSGWKIPDMGNVHLELSPDEQRIHQ-----LILSNETAIH 77
Cdd:cd03801     8 ELPPPVGGAERHVRELARALAARgHDVTVLTPADPGEPPEELEDGVIVPLLPSLAALLRARRLLRelrplLRLRKFDVVH 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1554490347  78 VFSGIDAYPMVFRAFKQCIQLKRTTLIYMEPYQTGGISGQLRRLKYALLYLKYGKKIqalLATGKFGVQAYRRSGW-PAS 156
Cdd:cd03801    88 AHGLLAALLAALLALLLGAPLVVTLHGAEPGRLLLLLAAERRLLARAEALLRRADAV---IAVSEALRDELRALGGiPPE 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1554490347 157 RIFEWGYFTEqTKHSADEQNTDQQNSRIAPRLLYVGRLDNNKRILHLIHALKSFRFQID--TFTVIG-TGPLVKETESLI 233
Cdd:cd03801   165 KIVVIPNGVD-LERFSPPLRRKLGIPPDRPVLLFVGRLSPRKGVDLLLEALAKLLRRGPdvRLVIVGgDGPLRAELEELE 243

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1554490347 234 HEEG-NFRYLGKQANENVLRIMQSHDLLILPSMYDGWGAVINEALQQGMRVLCSDRCGASCLLD 296
Cdd:cd03801   244 LGLGdRVRFLGFVPDEELPALYAAADVFVLPSRYEGFGLVVLEAMAAGLPVVATDVGGLPEVVE 307
 
Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 4-296 2.72e-22

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 96.84  E-value: 2.72e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1554490347   4 KFLFWQNMISIHQTALLNALASK-HQVTLAVQRAFEEERTDSGWKIPDMGNVHLELSPDEQRIHQ-----LILSNETAIH 77
Cdd:cd03801     8 ELPPPVGGAERHVRELARALAARgHDVTVLTPADPGEPPEELEDGVIVPLLPSLAALLRARRLLRelrplLRLRKFDVVH 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1554490347  78 VFSGIDAYPMVFRAFKQCIQLKRTTLIYMEPYQTGGISGQLRRLKYALLYLKYGKKIqalLATGKFGVQAYRRSGW-PAS 156
Cdd:cd03801    88 AHGLLAALLAALLALLLGAPLVVTLHGAEPGRLLLLLAAERRLLARAEALLRRADAV---IAVSEALRDELRALGGiPPE 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1554490347 157 RIFEWGYFTEqTKHSADEQNTDQQNSRIAPRLLYVGRLDNNKRILHLIHALKSFRFQID--TFTVIG-TGPLVKETESLI 233
Cdd:cd03801   165 KIVVIPNGVD-LERFSPPLRRKLGIPPDRPVLLFVGRLSPRKGVDLLLEALAKLLRRGPdvRLVIVGgDGPLRAELEELE 243

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1554490347 234 HEEG-NFRYLGKQANENVLRIMQSHDLLILPSMYDGWGAVINEALQQGMRVLCSDRCGASCLLD 296
Cdd:cd03801   244 LGLGdRVRFLGFVPDEELPALYAAADVFVLPSRYEGFGLVVLEAMAAGLPVVATDVGGLPEVVE 307
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 186-291 4.91e-18

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 80.40  E-value: 4.91e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1554490347 186 PRLLYVGRLDNNKRILHLIHALKSFRFQID--TFTVIGTGPLVKETESLIHEEG---NFRYLGKQANENVLRIMQSHDLL 260
Cdd:pfam00534   3 KIILFVGRLEPEKGLDLLIKAFALLKEKNPnlKLVIAGDGEEEKRLKKLAEKLGlgdNVIFLGFVSDEDLPELLKIADVF 82

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1554490347 261 ILPSMYDGWGAVINEALQQGMRVLCSDRCGA 291
Cdd:pfam00534  83 VLPSRYEGFGIVLLEAMACGLPVIASDVGGP 113
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 253-321 9.32e-06

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 44.60  E-value: 9.32e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1554490347 253 IMQSHDLLILPSMYDGWGAVINEALQQGMRVLCSDRCGASCLLDGIHRGGTFSWNEKGSLERELRHWIS 321
Cdd:COG0438    17 LLAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVPPGDPEALAEAILRLLE 85
 
Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 4-296 2.72e-22

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 96.84  E-value: 2.72e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1554490347   4 KFLFWQNMISIHQTALLNALASK-HQVTLAVQRAFEEERTDSGWKIPDMGNVHLELSPDEQRIHQ-----LILSNETAIH 77
Cdd:cd03801     8 ELPPPVGGAERHVRELARALAARgHDVTVLTPADPGEPPEELEDGVIVPLLPSLAALLRARRLLRelrplLRLRKFDVVH 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1554490347  78 VFSGIDAYPMVFRAFKQCIQLKRTTLIYMEPYQTGGISGQLRRLKYALLYLKYGKKIqalLATGKFGVQAYRRSGW-PAS 156
Cdd:cd03801    88 AHGLLAALLAALLALLLGAPLVVTLHGAEPGRLLLLLAAERRLLARAEALLRRADAV---IAVSEALRDELRALGGiPPE 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1554490347 157 RIFEWGYFTEqTKHSADEQNTDQQNSRIAPRLLYVGRLDNNKRILHLIHALKSFRFQID--TFTVIG-TGPLVKETESLI 233
Cdd:cd03801   165 KIVVIPNGVD-LERFSPPLRRKLGIPPDRPVLLFVGRLSPRKGVDLLLEALAKLLRRGPdvRLVIVGgDGPLRAELEELE 243

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1554490347 234 HEEG-NFRYLGKQANENVLRIMQSHDLLILPSMYDGWGAVINEALQQGMRVLCSDRCGASCLLD 296
Cdd:cd03801   244 LGLGdRVRFLGFVPDEELPALYAAADVFVLPSRYEGFGLVVLEAMAAGLPVVATDVGGLPEVVE 307
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 186-291 4.91e-18

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 80.40  E-value: 4.91e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1554490347 186 PRLLYVGRLDNNKRILHLIHALKSFRFQID--TFTVIGTGPLVKETESLIHEEG---NFRYLGKQANENVLRIMQSHDLL 260
Cdd:pfam00534   3 KIILFVGRLEPEKGLDLLIKAFALLKEKNPnlKLVIAGDGEEEKRLKKLAEKLGlgdNVIFLGFVSDEDLPELLKIADVF 82

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1554490347 261 ILPSMYDGWGAVINEALQQGMRVLCSDRCGA 291
Cdd:pfam00534  83 VLPSRYEGFGIVLLEAMACGLPVIASDVGGP 113
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
185-299 8.98e-16

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 73.31  E-value: 8.98e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1554490347 185 APRLLYVGRLD-NNKRILHLIHALKSFRFQID--TFTVIGTGPLvKETESLIHE-EGNFRYLGKQanENVLRIMQSHDLL 260
Cdd:pfam13692   1 RPVILFVGRLHpNVKGVDYLLEAVPLLRKRDNdvRLVIVGDGPE-EELEELAAGlEDRVIFTGFV--EDLAELLAAADVF 77

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1554490347 261 ILPSMYDGWGAVINEALQQGMRVLCSDRCGASCLLDGIH 299
Cdd:pfam13692  78 VLPSLYEGFGLKLLEAMAAGLPVVATDVGGIPELVDGEN 116
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 19-297 2.26e-13

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 70.46  E-value: 2.26e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1554490347  19 LLNALA-SKHQVTLAVQRafeeertDSGW-KIPDMGNVHLELSPDEQRIHQLILS-----------NETAI-HVFSGIDA 84
Cdd:cd03811    21 LANALDkRGYDVTLVLLR-------DEGDlDKQLNGDVKLIRLLIRVLKLIKLGLlkailklkrilKRAKPdVVISFLGF 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1554490347  85 YPMVFRAFKqciqLKRTTLIYMEpyqtGGISGQLRRLKYA-LLYLKYGKKIQALLATGKFGVQAYRRSGW-PASRI---- 158
Cdd:cd03811    94 ATYIVAKLA----AARSKVIAWI----HSSLSKLYYLKKKlLLKLKLYKKADKIVCVSKGIKEDLIRLGPsPPEKIeviy 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1554490347 159 --FEWGYFTEQTKHSADEQNTDqqnsriAPRLLYVGRLDNNKRILHLIHALKSFRFQID--TFTVIGTGPLVKETESLIH 234
Cdd:cd03811   166 npIDIDRIRALAKEPILNEPED------GPVILAVGRLDPQKGHDLLIEAFAKLRKKYPdvKLVILGDGPLREELEKLAK 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1554490347 235 E---EGNFRYLGKQAneNVLRIMQSHDLLILPSMYDGWGAVINEALQQGMRVLCSDRCGASCLLDG 297
Cdd:cd03811   240 ElglAERVIFLGFQS--NPYPYLKKADLFVLSSRYEGFPNVLLEAMALGTPVVSTDCPGPREILDD 303
GT4_UGDG-like cd03817
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ...
 186-321 6.12e-12

UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.


Pssm-ID: 340844 [Multi-domain]  Cd Length: 372  Bit Score: 66.15  E-value: 6.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1554490347 186 PRLLYVGRLDNNKRILHLIHALKSFRFQIDT-FTVIGTGPLVKETESLIHEEG---NFRYLGKQANENVLRIMQSHDLLI 261
Cdd:cd03817   202 PILLYVGRLAKEKNIDFLLRAFAELKKEPNIkLVIVGDGPEREELKELARELGladKVIFTGFVPREELPEYYKAADLFV 281

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1554490347 262 LPSMYDGWGAVINEALQQGMRVLCSDrcgASCLLDGIHRG--GTFSWNEKGSLERELRHWIS 321
Cdd:cd03817   282 FASTTETQGLVYLEAMAAGLPVVAAK---DPAASELVEDGenGFLFEPNDETLAEKLLHLRE 340
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
 186-287 7.28e-12

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 66.08  E-value: 7.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1554490347 186 PRLLYVGRLDNNKRILHLIHALKSFRFQID--TFTVIGTGPLVKETESLI---HEEGNFRYLGKQanENVLRIMQSHDLL 260
Cdd:cd03808   190 VVFLFVARLLKDKGIDELIEAAKILKKKGPnvRFLLVGDGELENPSEILIeklGLEGRIEFLGFR--SDVPELLAESDVF 267

                          90       100
                  ....*....|....*....|....*..
gi 1554490347 261 ILPSMYDGWGAVINEALQQGMRVLCSD 287
Cdd:cd03808   268 VLPSYREGLPRSLLEAMAAGRPVITTD 294
GT4-like cd05844
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar ...
 185-303 1.60e-10

glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to glycosyltransferase family 4 (GT4). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340860 [Multi-domain]  Cd Length: 365  Bit Score: 61.70  E-value: 1.60e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1554490347 185 APRLLYVGRLDNNKRILHLIHALKSFRFQIDT--FTVIGTGPLVKETESLIHEEGNFRYLGKQANENVLRIMQSHDLLIL 262
Cdd:cd05844   189 APTILFVGRLVEKKGCDVLIEAFRRLAARHPTarLVIAGDGPLRPALQALAAALGRVRFLGALPHAEVQDWMRRAEIFCL 268

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1554490347 263 PSMY------DGWGAVINEALQQGMRVLCSDRCGAScllDGIHRGGT 303
Cdd:cd05844   269 PSVTaasgdsEGLGIVLLEAAACGVPVVSSRHGGIP---EAILDGET 312
Glycosyltransferase_GTB-type cd01635
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 189-290 4.67e-10

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340816 [Multi-domain]  Cd Length: 235  Bit Score: 59.34  E-value: 4.67e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1554490347 189 LYVGRLDNNKRILHLIHALKSF--RFQIDTFTVIGTGPLVKETESLIHEEG----NFRYLGKQANENVLRIMQSHDLLIL 262
Cdd:cd01635   114 VSVGRLVPEKGIDLLLEALALLkaRLPDLVLVLVGGGGEREEEEALAAALGllerVVIIGGLVDDEVLELLLAAADVFVL 193

                          90       100
                  ....*....|....*....|....*...
gi 1554490347 263 PSMYDGWGAVINEALQQGMRVLCSDRCG 290
Cdd:cd01635   194 PSRSEGFGLVLLEAMAAGKPVIATDVGG 221
GT4_AmsD-like cd03820
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ...
 173-289 2.69e-09

amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.


Pssm-ID: 340847 [Multi-domain]  Cd Length: 351  Bit Score: 58.02  E-value: 2.69e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1554490347 173 DEQNTDQQNSRiapRLLYVGRLDNNKRILHLIHALKSFRFQIDTFTV--IGTGPLVKETESLIHE---EGNFRYLGKQAN 247
Cdd:cd03820   172 SEEPSTNLKSK---RILAVGRLTYQKGFDLLIEAWALIAKKHPDWKLriYGDGPEREELEKLIDKlglEDRVKLLGPTKN 248

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1554490347 248 ENVLriMQSHDLLILPSMYDGWGAVINEALQQGMRVLCSDRC 289
Cdd:cd03820   249 IAEE--YANSSIFVLSSRYEGFPMVLLEAMAYGLPIISFDCP 288
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
 185-291 1.33e-08

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 55.85  E-value: 1.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1554490347 185 APRLLYVGRLDNNKRILHLIHALKSFRFQID--TFTVIGTGP----LVKETESLiHEEGNFRYLGKQANENVLRIMQSHD 258
Cdd:cd03798   200 AFVILFVGRLIPRKGIDLLLEAFARLAKARPdvVLLIVGDGPlreaLRALAEDL-GLGDRVTFTGRLPHEQVPAYYRACD 278

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1554490347 259 LLILPSMYDGWGAVINEALQQGMRVLCSDrCGA 291
Cdd:cd03798   279 VFVLPSRHEGFGLVLLEAMACGLPVVATD-VGG 310
GT4_Bme6-like cd03821
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ...
 76-290 1.68e-08

Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.


Pssm-ID: 340848 [Multi-domain]  Cd Length: 377  Bit Score: 55.84  E-value: 1.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1554490347  76 IHvfsGIDAYPmVFRAFKQCIQLKRTTLIY----MEPYqtggiSGQLRRLKYALLYLKYGKKIQALLATGKF-GVQAYRR 150
Cdd:cd03821    96 IH---GVWTYT-SLAACKLARRRGIPYVVSphgmLDPW-----ALQQKHWKKRIALHLIERRNLNNAALVHFtSEQEADE 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1554490347 151 SGW----PASRIFEWGYFTEQtKHSADEQNTDQQNSRIAPRLLYVGRLDNNKRILHLIHALKSFRFQIDTFTVIGTGPLV 226
Cdd:cd03821   167 LRRfglePPIAVIPNGVDIPE-FDPGLRDRRKHNGLEDRRIILFLGRIHPKKGLDLLIRAARKLAEQGRDWHLVIAGPDD 245

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1554490347 227 KETESLIHEEGNF------RYLGKQANENVLRIMQSHDLLILPSMYDGWGAVINEALQQGMRVLCSDRCG 290
Cdd:cd03821   246 GAYPAFLQLQSSLglgdrvTFTGPLYGEAKWALYASADLFVLPSYSENFGNVVAEALACGLPVVITDKCG 315
GT4_ExpE7-like cd03823
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ...
 160-333 5.91e-08

glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).


Pssm-ID: 340850 [Multi-domain]  Cd Length: 357  Bit Score: 53.87  E-value: 5.91e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1554490347 160 EWGYFTEQ--------TKHSADEQNTDQQNSRIapRLLYVGRLDNNKRILHLIHALKSFRFQIDTFTVIGTGPLvkETES 231
Cdd:cd03823   160 ANGLFSARisvipnavEPDLAPPPRRRPGTERL--RFGYIGRLTEEKGIDLLVEAFKRLPREDIELVIAGHGPL--SDER 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1554490347 232 LIHEEGNFRYLGKQANENVLRIMQSHDLLILPSM-YDGWGAVINEALQQGMRVLCSDRcGASCLLDGIHRGG-TFSWNEK 309
Cdd:cd03823   236 QIEGGRRIAFLGRVPTDDIKDFYEKIDVLVVPSIwPEPFGLVVREAIAAGLPVIASDL-GGIAELIQPGVNGlLFAPGDA 314

                         170       180
                  ....*....|....*....|....
gi 1554490347 310 GSLERELRHWISKGPITQKERTGI 333
Cdd:cd03823   315 EDLAAAMRRLLTDPALLERLRAGA 338
GT4_CapH-like cd03812
capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This ...
 190-288 1.28e-07

capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1).


Pssm-ID: 340840 [Multi-domain]  Cd Length: 357  Bit Score: 53.06  E-value: 1.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1554490347 190 YVGRLD---NNKRILHLIHALKSFR--FQIdtfTVIGTGPLVKETESLIHEEG---NFRYLGKQanENVLRIMQSHDLLI 261
Cdd:cd03812   196 HVGRFNeqkNHSFLIDIFEELKKKNpnVKL---VLVGEGELKEKIKEKVKELGledKVIFLGFR--NDVSEILSAMDVFL 270

                          90       100
                  ....*....|....*....|....*..
gi 1554490347 262 LPSMYDGWGAVINEALQQGMRVLCSDR 288
Cdd:cd03812   271 FPSLYEGLPLVAVEAQASGLPCLLSDT 297
GT4_AmsK-like cd03799
Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases ...
 187-298 2.44e-07

Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases found specifically in certain bacteria. AmsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor.


Pssm-ID: 340829 [Multi-domain]  Cd Length: 350  Bit Score: 52.07  E-value: 2.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1554490347 187 RLLYVGRLDNNKRILHLIHA---LKSFRFQIDtFTVIGTGPLVKETESLIHE---EGNFRYLGKQANENVLRIMQSHDLL 260
Cdd:cd03799   176 RILTVGRLTEKKGLEYAIEAvakLAQKYPNIE-YQIIGDGDLKEQLQQLIQElniGDCVKLLGWKPQEEIIEILDEADIF 254

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1554490347 261 ILPSM------YDGWGAVINEALQQGMRVLCSDRCGASCLL-DGI 298
Cdd:cd03799   255 IAPSVtaadgdQDGPPNTLKEAMAMGLPVISTEHGGIPELVeDGV 299
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
 124-296 5.00e-07

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 51.16  E-value: 5.00e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1554490347 124 ALLYLKYGKKIQALLATGKFGVQAYRRSGWPASR---IFEwGYftEQTKHSADEQNTDQQNSRI-----APRLLYVGRLD 195
Cdd:cd03807   124 RKLCLLLSKFSPATVANSSAVAEFHQEQGYAKNKivvIYN-GI--DLFKLSPDDASRARARRRLglaedRRVIGIVGRLH 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1554490347 196 NNKRILHLIHA---LKSFRFQIdTFTVIGTGPLVKETESLIHE---EGNFRYLGKQanENVLRIMQSHDLLILPSMYDGW 269
Cdd:cd03807   201 PVKDHSDLLRAaalLVETHPDL-RLLLVGRGPERPNLERLLLElglEDRVHLLGER--SDVPALLPAMDIFVLSSRTEGF 277

                         170       180
                  ....*....|....*....|....*..
gi 1554490347 270 GAVINEALQQGMRVLCSDRCGASCLLD 296
Cdd:cd03807   278 PNALLEAMACGLPVVATDVGGAAELVD 304
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 18-288 8.88e-07

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 50.44  E-value: 8.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1554490347  18 ALLNALASK--HQVTLAVQRAFEEERTDSGWKIPDMGNVHLELspdeqRIHQLILSNETAIHV--FSGIDAYP-MVFRAF 92
Cdd:cd03809    22 ELLKALAKNdpDESVLAVPPLPGELLRLLREYPELSLGVIKIK-----LWRELALLRWLQILLpkKDKPDLLHsPHNTAP 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1554490347  93 KQCIQLKRTTLIY-MEPYQTGGISGQLRRLkyallYLKYGKKIQALLATGKFGVQAY------RRSGWPASRIFeWGYFT 165
Cdd:cd03809    97 LLLKGCPQVVTIHdLIPLRYPEFFPKRFRL-----YYRLLLPISLRRADAIITVSEAtrddiiKFYGVPPEKIV-VIPLG 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1554490347 166 EQTKHSADEQNTDQQNSRIAPR--LLYVGRLDNNKRILHLIHALKSFRFQ-IDTFTVI--GTGPLVKETESLIHE---EG 237
Cdd:cd03809   171 VDPSFFPPESAAVLIAKYLLPEpyFLYVGTLEPRKNHERLLKAFALLKKQgGDLKLVIvgGKGWEDEELLDLVKKlglGG 250

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1554490347 238 NFRYLGKQANENVLRIMQSHDLLILPSMYDGWGAVINEALQQGMRVLCSDR 288
Cdd:cd03809   251 RVRFLGYVSDEDLPALYRGARAFVFPSLYEGFGLPVLEAMACGTPVIASNI 301
GT4_WavL-like cd03819
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ...
 186-287 1.48e-06

Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.


Pssm-ID: 340846 [Multi-domain]  Cd Length: 345  Bit Score: 49.66  E-value: 1.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1554490347 186 PRLLYVGRLDNNKRILHLIHALKSFRFQID-TFTVIGTGPLVKETESLIHE---EGNFRYLGkqANENVLRIMQSHDLLI 261
Cdd:cd03819   183 PVVGYVGRLSPEKGWLLLVDAAAELKDEPDfRLLVAGDGPERDEIRRLVERlglRDRVTFTG--FREDVPAALAASDVVV 260

                          90       100
                  ....*....|....*....|....*.
gi 1554490347 262 LPSMYDGWGAVINEALQQGMRVLCSD 287
Cdd:cd03819   261 LPSLHEEFGRVALEAMACGTPVVATD 286
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 253-321 9.32e-06

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 44.60  E-value: 9.32e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1554490347 253 IMQSHDLLILPSMYDGWGAVINEALQQGMRVLCSDRCGASCLLDGIHRGGTFSWNEKGSLERELRHWIS 321
Cdd:COG0438    17 LLAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVPPGDPEALAEAILRLLE 85
GT4_WbdM_like cd04951
LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most ...
 188-290 2.46e-05

LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340857 [Multi-domain]  Cd Length: 360  Bit Score: 45.90  E-value: 2.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1554490347 188 LLYVGRLDNNKRILHLIHALKSFRFQIDTF--TVIGTGPLVKETESLI---HEEGNFRYLGKQANenVLRIMQSHDLLIL 262
Cdd:cd04951   191 ILNVGRLTEAKDYPNLLLAISELILSKNDFklLIAGDGPLRNELERLIcnlNLVDRVILLGQISN--ISEYYNAADLFVL 268

                          90       100
                  ....*....|....*....|....*...
gi 1554490347 263 PSMYDGWGAVINEALQQGMRVLCSDRCG 290
Cdd:cd04951   269 SSEWEGFGLVVAEAMACERPVVATDAGG 296
GT4-like cd03814
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 149-292 1.03e-04

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340842 [Multi-domain]  Cd Length: 365  Bit Score: 43.82  E-value: 1.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1554490347 149 RRSGWPASRIFEWGY------FTEQTKHSADEQNTDQQNsriAPRLLYVGRLDNNKRILHLIHALKSFRFQID-TFTVIG 221
Cdd:cd03814   159 ELEGHGFERVRLWPRgvdtelFHPSRRDAALRRRLGPPG---RPLLLYVGRLAPEKNLEALLDADLPLAASPPvRLVVVG 235

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1554490347 222 TGPlvkETESLIHEEGNFRYLGKQANENVLRIMQSHDLLILPSMYDGWGAVINEALQQGMRVLCSDRCGAS 292
Cdd:cd03814   236 DGP---ARAELEARGPDVIFTGFLTGEELARAYASADVFVFPSRTETFGLVVLEAMASGLPVVAADAGGPR 303
GT4_WfcD-like cd03795
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ...
 189-264 8.78e-04

Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340826 [Multi-domain]  Cd Length: 355  Bit Score: 41.11  E-value: 8.78e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1554490347 189 LYVGRLDNNKRILHLIHALKSFRFQIdtfTVIGTGPLVKETESLIHEEG--NFRYLGKQANENVLRIMQSHDLLILPS 264
Cdd:cd03795   195 LFIGRLVYYKGLDYLIEAAQYLNYPI---VIGGEGPLKPDLEAQIELNLldNVKFLGRVDDEEKVIYLHLCDVFVFPS 269
GT4_sucrose_synthase cd03800
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ...
 185-340 9.54e-04

sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.


Pssm-ID: 340830 [Multi-domain]  Cd Length: 398  Bit Score: 41.07  E-value: 9.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1554490347 185 APRLLYVGRLDNNKRILHLIHAL-KSFRFQIDTFTVIGTGPL-------VKETESLIHEEGN---FRYLGKQANENVLRI 253
Cdd:cd03800   220 KPVVLALGRLDPRKGIDTLVRAFaQLPELRELANLVLVGGPSddplsmdREELAELAEELGLidrVRFPGRVSRDDLPEL 299

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1554490347 254 MQSHDLLILPSMYDGWGAVINEALQQGMRVLCSDRCG-ASCLLDGIHrGGTFSWNEKGSLERELRHWISKGPITQKERTG 332
Cdd:cd03800   300 YRAADVFVVPSLYEPFGLTAIEAMACGTPVVATAVGGlQDIVRDGRT-GLLVDPHDPEALAAALRRLLDDPALWQRLSRA 378

                         170
                  ....*....|....*
gi 1554490347 333 IA-------SWAKTT 340
Cdd:cd03800   379 GLerarahyTWESVA 393
GT4_BshA-like cd04962
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ...
 198-287 7.61e-03

N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340859 [Multi-domain]  Cd Length: 370  Bit Score: 38.10  E-value: 7.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1554490347 198 KRILHLIHALKSFRFQID-TFTVIGTGPLVKETESLIHE---EGNFRYLGKQanENVLRIMQSHDLLILPSMYDGWGAVI 273
Cdd:cd04962   209 KRIDDVVRVFARVRRKIPaKLLLVGDGPERVPAEELARElgvEDRVLFLGKQ--DDVEELLSIADLFLLPSEKESFGLAA 286

                          90
                  ....*....|....
gi 1554490347 274 NEALQQGMRVLCSD 287
Cdd:cd04962   287 LEAMACGVPVVSSN 300
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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