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Conserved domains on  [gi|1548924281|gb|AZU30624|]
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carbohydrate kinase [Xanthomonas sp. ISO98C4]

Protein Classification

carbohydrate kinase family protein( domain architecture ID 1008582)

carbohydrate kinase family protein similar to bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, allowing the repair of both epimers of NAD(P)HX

CATH:  3.40.1190.20|3.40.50.10260
EC:  5.1.99.6
Gene Ontology:  GO:0005524|GO:0052857
PubMed:  21994945

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK10565 super family cl32537
putative carbohydrate kinase; Provisional
 14-490 5.36e-142

putative carbohydrate kinase; Provisional


The actual alignment was detected with superfamily member PRK10565:

Pssm-ID: 182554 [Multi-domain]  Cd Length: 508  Bit Score: 417.54  E-value: 5.36e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281  14 RTLDAQATTLLGGDGYTLMQRAGQAAWQWLLERWPQARRIVVVCGTGNNGGDGYVLARLAHRAGRQVGVVHLPEHGPASD 93
Cdd:PRK10565   24 RRGEREAADALGLTLYELMLRAGEAAFQVARSAYPDARHWLVLCGHGNNGGDGYVVARLAQAAGIDVTLLAQESDKPLPE 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281  94 LAQRACTDYLAVGGAIELFPYPLAQA-DVIVDALFGIGLNRAPDDATAGLIDAINAADVPVFALDVPSGIDADHGVAFGA 172
Cdd:PRK10565  104 EAALAREAWLNAGGEIHAADIVWPESvDLIVDALLGTGLRQAPREPYAALIDQANAHPAPVVALDIPSGLLAETGATPGA 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281 173 AVRAALTLQFIVPHLGLYTGDALEHAGEREVASLEVPVSAFDGLAPAAHgWNGDAVAAQLRPRRRNTHKGESGRVLCVGG 252
Cdd:PRK10565  184 VINADHTVTFIALKPGLLTGKARDVVGQLHFDSLGLDSWLAGQEAPIQR-FDAEQLSQWLKPRRPTSHKGDHGRLLIIGG 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281 253 NLGSGGAIMLTAEAALRSGAGLVQVATRAEHVTPLLARCPEAMARAMQADDDIATLaEAADAVALGPGLGQDAWAQALWR 332
Cdd:PRK10565  263 DHGTAGAIRMAGEAALRSGAGLVRVLTRSENIAPLLTARPELMVHELTPDSLEESL-EWADVVVIGPGLGQQEWGKKALQ 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281 333 AALGAATAMVIDADGLNLLAANDvAARGPRILTPHPGEAGRLLGLSTRQIQRDRPAAAAALAKRYDAVVVLKGAGTVVAS 412
Cdd:PRK10565  342 KVENFRKPMLWDADALNLLAINP-DKRHNRVITPHPGEAARLLGCSVAEIESDRLLSARRLVKRYGGVVVLKGAGTVIAA 420

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1548924281 413 PGHLPRIIDAGNPGMAVGGMGDLLTGVIAALLAQGFSPFDAASLGALL-HACAGDAAAHAGERGLLPTDLLPELRRLAN 490
Cdd:PRK10565  421 EPDALAIIDVGNAGMASGGMGDVLSGIIGALLGQKLSPYDAACAGCVAhGAAADVLAARFGTRGMLATDLFSTLQRIVN 499
 
Name Accession Description Interval E-value
PRK10565 PRK10565
putative carbohydrate kinase; Provisional
 14-490 5.36e-142

putative carbohydrate kinase; Provisional


Pssm-ID: 182554 [Multi-domain]  Cd Length: 508  Bit Score: 417.54  E-value: 5.36e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281  14 RTLDAQATTLLGGDGYTLMQRAGQAAWQWLLERWPQARRIVVVCGTGNNGGDGYVLARLAHRAGRQVGVVHLPEHGPASD 93
Cdd:PRK10565   24 RRGEREAADALGLTLYELMLRAGEAAFQVARSAYPDARHWLVLCGHGNNGGDGYVVARLAQAAGIDVTLLAQESDKPLPE 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281  94 LAQRACTDYLAVGGAIELFPYPLAQA-DVIVDALFGIGLNRAPDDATAGLIDAINAADVPVFALDVPSGIDADHGVAFGA 172
Cdd:PRK10565  104 EAALAREAWLNAGGEIHAADIVWPESvDLIVDALLGTGLRQAPREPYAALIDQANAHPAPVVALDIPSGLLAETGATPGA 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281 173 AVRAALTLQFIVPHLGLYTGDALEHAGEREVASLEVPVSAFDGLAPAAHgWNGDAVAAQLRPRRRNTHKGESGRVLCVGG 252
Cdd:PRK10565  184 VINADHTVTFIALKPGLLTGKARDVVGQLHFDSLGLDSWLAGQEAPIQR-FDAEQLSQWLKPRRPTSHKGDHGRLLIIGG 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281 253 NLGSGGAIMLTAEAALRSGAGLVQVATRAEHVTPLLARCPEAMARAMQADDDIATLaEAADAVALGPGLGQDAWAQALWR 332
Cdd:PRK10565  263 DHGTAGAIRMAGEAALRSGAGLVRVLTRSENIAPLLTARPELMVHELTPDSLEESL-EWADVVVIGPGLGQQEWGKKALQ 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281 333 AALGAATAMVIDADGLNLLAANDvAARGPRILTPHPGEAGRLLGLSTRQIQRDRPAAAAALAKRYDAVVVLKGAGTVVAS 412
Cdd:PRK10565  342 KVENFRKPMLWDADALNLLAINP-DKRHNRVITPHPGEAARLLGCSVAEIESDRLLSARRLVKRYGGVVVLKGAGTVIAA 420

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1548924281 413 PGHLPRIIDAGNPGMAVGGMGDLLTGVIAALLAQGFSPFDAASLGALL-HACAGDAAAHAGERGLLPTDLLPELRRLAN 490
Cdd:PRK10565  421 EPDALAIIDVGNAGMASGGMGDVLSGIIGALLGQKLSPYDAACAGCVAhGAAADVLAARFGTRGMLATDLFSTLQRIVN 499
Nnr2 COG0063
NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate dehydratase domain [Nucleotide transport ...
 219-491 1.56e-94

NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate dehydratase domain [Nucleotide transport and metabolism];


Pssm-ID: 439833  Cd Length: 280  Bit Score: 287.79  E-value: 1.56e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281 219 AAHGWNGDAVAAQLRPRRRNTHKGESGRVLCVGGNLGSGGAIMLTAEAALRSGAGLVQVATRAEHVTPLLARCPEAMARA 298
Cdd:COG0063     1 DARLLTPADLRALLPPRPPDSHKGSRGHVLVIGGSRGYPGAAVLAARAALRAGAGLVTVAVPESAAPAVAAALPELMVIP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281 299 MQADDDIATLAEAADAVALGPGLGQDAWAQALWRAALGAAT-AMVIDADGLNLLAANDV---AARGPRILTPHPGEAGRL 374
Cdd:COG0063    81 LPEEDELLELLERADAVVIGPGLGRDEETRELLRALLEAADkPLVLDADALNLLAEDPEllaALPAPTVLTPHPGEFARL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281 375 LGLSTRQIQRDRPAAAAALAKRYDAVVVLKGAGTVVASPGHLPRIIDAGNPGMAVGGMGDLLTGVIAALLAQGFSPFDAA 454
Cdd:COG0063   161 LGCSVAEIQADRLEAAREAAKRYGAVVVLKGAGTVIAAPDGRVYINPTGNPGLATAGSGDVLAGIIAGLLAQGLDPFEAA 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1548924281 455 SLGALLHACAGDAAAHAGERGLLPTDLLPELRRLANA 491
Cdd:COG0063   241 AAGVYLHGLAGDLAAEERGRGLLASDLIEALPAALRE 277
YXKO-related cd01171
B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of ...
 237-486 5.43e-79

B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.


Pssm-ID: 238576  Cd Length: 254  Bit Score: 247.14  E-value: 5.43e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281 237 RNTHKGESGRVLCVGGNLGSGGAIMLTAEAALRSGAGLVQVATRAEHVTPLLARCPEAMARA--MQADDDIATLAEAADA 314
Cdd:cd01171     1 PDSHKGSRGRVLVIGGSRGYTGAAYLAALAALRAGAGLVTVATPPEAAAVIKSYSPELMVHPllETDIEELLELLERADA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281 315 VALGPGLGQDAWAQALWRAALGAATAMVIDADGLNLLAANDVAARGPR--ILTPHPGEAGRLLGLSTRQIQRDRPAAAAA 392
Cdd:cd01171    81 VVIGPGLGRDEEAAEILEKALAKDKPLVLDADALNLLADEPSLIKRYGpvVLTPHPGEFARLLGALVEEIQADRLAAARE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281 393 LAKRYDAVVVLKGAGTVVASPGHLPRIIDAGNPGMAVGGMGDLLTGVIAALLAQGFSPFDAASLGALLHACAGDAAAHAG 472
Cdd:cd01171   161 AAAKLGATVVLKGAVTVIADPDGRVYVNPTGNPGLATGGSGDVLAGIIAALLAQGLSPLEAAALAVYLHGLAGDLAAKKK 240

                         250
                  ....*....|....
gi 1548924281 473 ERGLLPTDLLPELR 486
Cdd:cd01171   241 GAGLTAADLVAEIP 254
yjeF_cterm TIGR00196
yjeF C-terminal region, hydroxyethylthiazole kinase-related; E. coli yjeF has full-length ...
 223-490 2.90e-66

yjeF C-terminal region, hydroxyethylthiazole kinase-related; E. coli yjeF has full-length orthologs in a number of species, all of unknown function. However, yeast YNL200C is homologous and corresponds to the N-terminal region while yeast YKL151C and B. subtilis yxkO correspond to this C-terminal region only. The present model may hit hydroxyethylthiazole kinase, an enzyme associated with thiamine biosynthesis. [Unknown function, General]


Pssm-ID: 272955  Cd Length: 270  Bit Score: 214.56  E-value: 2.90e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281 223 WNGDAVAAQLRPRRRNTHKGESGRVLCVGGNLGSGGAIMLTAEAALRSGAGLVQVATRAEHVTPLLARCPEAMARA-MQA 301
Cdd:TIGR00196   3 FLGEGDLLTLPLRDPNSHKGQYGRVLIIGGSDDYSGAPLLAALAALRAGAGLVTVAAPENVITLINSVSPELIVHRlMWK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281 302 DDDIATLAEAADAVALGPGLGQDAWAQALWRAALGAATAMVIDADGLNLLAANDVAaRGPRILTPHPGEAGRLLGLStrQ 381
Cdd:TIGR00196  83 VDEDEELLERYDVVVIGPGLGQDPSFKKAVEEVLELDKPVVLDADALNLLTYNQKR-EGEVILTPHPGEFKRLLGVN--E 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281 382 IQRDRPAAAAALAKRYDAVVVLKGAGTVVASPGHLPRIIDAGNPGMAVGGMGDLLTGVIAALLAQGFSPFDAASLGALL- 460
Cdd:TIGR00196 160 IQGDRLEAAQDIAQKLQAVVVLKGAADVIAAPDGDLWINKTGNAALAKGGTGDVLAGLIGGLLAQNLDPFDAACNAAFAh 239

                         250       260       270
                  ....*....|....*....|....*....|
gi 1548924281 461 HACAGDAAAHAGERGLLPTDLLPELRRLAN 490
Cdd:TIGR00196 240 GLAGDLALKNHGAYGLTALDLIEKIPRVCK 269
Carb_kinase pfam01256
Carbohydrate kinase; This family is related to pfam02110 and pfam00294 implying that it also ...
 247-487 2.74e-54

Carbohydrate kinase; This family is related to pfam02110 and pfam00294 implying that it also is a carbohydrate kinase. (personal obs Yeats C).


Pssm-ID: 396007  Cd Length: 242  Bit Score: 182.56  E-value: 2.74e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281 247 VLCVGGNLGSGGAIMLTAEAALRSGAGLVQVATRAEHVTPLLARCPEAMARAMQADDDIATLAEAADAVALGPGLGQDAW 326
Cdd:pfam01256   1 VLVIGGSKDYTGAPLLAALAALRSGAGLVSVATDSEAIAVLKSPLPEVMVHPLPETSSILEKLSRYDAVVIGPGLGRDEK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281 327 AQALWRAALGAATAMVIDADGLNLLAANDVAA--RGPRILTPHPGEAGRLLGLSTrQIQRDRPAAAAALAKRYDAVVVLK 404
Cdd:pfam01256  81 GKAALEEVLAKDCPLVIDADALNLLAINNEKParEGPTVLTPHPGEFERLCGLAG-ILGDDRLEAARELAQKLNGTILLK 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281 405 GAGTVVASPGHLPRIIDAGNPGMAVGGMGDLLTGVIAALLAQGFSPFDAASLGALLHACAGDAAAHAGERGLLPTDLLPE 484
Cdd:pfam01256 160 GNVTVIAAPGGEVWINSTGNSALAKGGSGDVLAGLIGGLLAQNEDPYDAAIAAAWLHGAASDLAAENHGVYMLPTLLSKI 239


                  ...
gi 1548924281 485 LRR 487
Cdd:pfam01256 240 IPR 242
 
Name Accession Description Interval E-value
PRK10565 PRK10565
putative carbohydrate kinase; Provisional
 14-490 5.36e-142

putative carbohydrate kinase; Provisional


Pssm-ID: 182554 [Multi-domain]  Cd Length: 508  Bit Score: 417.54  E-value: 5.36e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281  14 RTLDAQATTLLGGDGYTLMQRAGQAAWQWLLERWPQARRIVVVCGTGNNGGDGYVLARLAHRAGRQVGVVHLPEHGPASD 93
Cdd:PRK10565   24 RRGEREAADALGLTLYELMLRAGEAAFQVARSAYPDARHWLVLCGHGNNGGDGYVVARLAQAAGIDVTLLAQESDKPLPE 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281  94 LAQRACTDYLAVGGAIELFPYPLAQA-DVIVDALFGIGLNRAPDDATAGLIDAINAADVPVFALDVPSGIDADHGVAFGA 172
Cdd:PRK10565  104 EAALAREAWLNAGGEIHAADIVWPESvDLIVDALLGTGLRQAPREPYAALIDQANAHPAPVVALDIPSGLLAETGATPGA 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281 173 AVRAALTLQFIVPHLGLYTGDALEHAGEREVASLEVPVSAFDGLAPAAHgWNGDAVAAQLRPRRRNTHKGESGRVLCVGG 252
Cdd:PRK10565  184 VINADHTVTFIALKPGLLTGKARDVVGQLHFDSLGLDSWLAGQEAPIQR-FDAEQLSQWLKPRRPTSHKGDHGRLLIIGG 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281 253 NLGSGGAIMLTAEAALRSGAGLVQVATRAEHVTPLLARCPEAMARAMQADDDIATLaEAADAVALGPGLGQDAWAQALWR 332
Cdd:PRK10565  263 DHGTAGAIRMAGEAALRSGAGLVRVLTRSENIAPLLTARPELMVHELTPDSLEESL-EWADVVVIGPGLGQQEWGKKALQ 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281 333 AALGAATAMVIDADGLNLLAANDvAARGPRILTPHPGEAGRLLGLSTRQIQRDRPAAAAALAKRYDAVVVLKGAGTVVAS 412
Cdd:PRK10565  342 KVENFRKPMLWDADALNLLAINP-DKRHNRVITPHPGEAARLLGCSVAEIESDRLLSARRLVKRYGGVVVLKGAGTVIAA 420

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1548924281 413 PGHLPRIIDAGNPGMAVGGMGDLLTGVIAALLAQGFSPFDAASLGALL-HACAGDAAAHAGERGLLPTDLLPELRRLAN 490
Cdd:PRK10565  421 EPDALAIIDVGNAGMASGGMGDVLSGIIGALLGQKLSPYDAACAGCVAhGAAADVLAARFGTRGMLATDLFSTLQRIVN 499
Nnr2 COG0063
NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate dehydratase domain [Nucleotide transport ...
 219-491 1.56e-94

NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate dehydratase domain [Nucleotide transport and metabolism];


Pssm-ID: 439833  Cd Length: 280  Bit Score: 287.79  E-value: 1.56e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281 219 AAHGWNGDAVAAQLRPRRRNTHKGESGRVLCVGGNLGSGGAIMLTAEAALRSGAGLVQVATRAEHVTPLLARCPEAMARA 298
Cdd:COG0063     1 DARLLTPADLRALLPPRPPDSHKGSRGHVLVIGGSRGYPGAAVLAARAALRAGAGLVTVAVPESAAPAVAAALPELMVIP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281 299 MQADDDIATLAEAADAVALGPGLGQDAWAQALWRAALGAAT-AMVIDADGLNLLAANDV---AARGPRILTPHPGEAGRL 374
Cdd:COG0063    81 LPEEDELLELLERADAVVIGPGLGRDEETRELLRALLEAADkPLVLDADALNLLAEDPEllaALPAPTVLTPHPGEFARL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281 375 LGLSTRQIQRDRPAAAAALAKRYDAVVVLKGAGTVVASPGHLPRIIDAGNPGMAVGGMGDLLTGVIAALLAQGFSPFDAA 454
Cdd:COG0063   161 LGCSVAEIQADRLEAAREAAKRYGAVVVLKGAGTVIAAPDGRVYINPTGNPGLATAGSGDVLAGIIAGLLAQGLDPFEAA 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1548924281 455 SLGALLHACAGDAAAHAGERGLLPTDLLPELRRLANA 491
Cdd:COG0063   241 AAGVYLHGLAGDLAAEERGRGLLASDLIEALPAALRE 277
Nnr1 COG0062
NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate epimerase domain [Nucleotide transport and ...
 7-495 3.78e-86

NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate epimerase domain [Nucleotide transport and metabolism];


Pssm-ID: 439832 [Multi-domain]  Cd Length: 499  Bit Score: 273.67  E-value: 3.78e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281   7 LYDTAAARTLDAQATTLLGGDGYTLMQRAGQAAWQWLLERWP-QARRIVVVCGTGNNGGDGYVLARLAHRAGRQVGVVHL 85
Cdd:COG0062     3 LLTAAQMRALDRAAIEALGIPGLVLMERAGRAVARAIRRRFPsAARRVLVLCGPGNNGGDGLVAARLLAEAGYNVTVFLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281  86 PEHGPASDLAQRACTDYLAVGGAIELF---PYPLAQADVIVDALFGIGLNRAPDDATAGLIDAINAADVPVFALDVPSGI 162
Cdd:COG0062    83 GDPEKLSGDAAANLERLKAAGIPILELddeLPELAEADLIVDALFGTGLSRPLRGPYAELIEAINASGAPVLAVDIPSGL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281 163 DADHGVAFGAAVRAALTLQFIVPHLGLYTGDALEHAGEREVASLeVPVSAFDGLAPAAHGWNGDAVAAQLRPRRRNTHKG 242
Cdd:COG0062   163 DADTGEVLGAAVRADLTVTFGAPKPGLLLGPGRDYCGELVVADI-GIGIPAAAEAPAALLLLADLLALLLPPRRRSHHKG 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281 243 ESGRVLCVGGNLGSGGAIMLTAEAALRSGAGLVQVATRAEHVTPLLARCPEAMARAMQADDDIATLAEAADAVALGPGLG 322
Cdd:COG0062   242 GGGGVLVIGGGGGGGGAAAAAAAAAAAAGGGLVVLAVPPAAAAALLAALPEAMALALDDDEELLLLLAAAVVVAGGGGGG 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281 323 QDAWAQALWRAALGAATAMVIDADGLNLLAANDVAARgPRILTPHPGEAGRLLGLSTRQIQRDRPAAAAALAKRYDAVVV 402
Cdd:COG0062   322 GGGAGGGLLLLLLLLLLLLVLLAAALLLLLALAAALL-LLLLLPPPLAAALLLLRLLTELLELRAAAAALLAAAAAAAAV 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281 403 LKGAGTVVASPGHLPRIIDAGNPGMAVGGMGDLLTGVIAALLAQGFSPFDAASLGALLHACAGDAAAHAGERGLLPTDLL 482
Cdd:COG0062   401 AAAAVVAGAAGVVVVAAAGGGGGGGGGGGGGGGGGGGGGGGGGGGLLAGAAAAAAAAAAAAAAAAAAAAAAAALAAALLA 480

                         490
                  ....*....|...
gi 1548924281 483 PELRRLANAGAIA 495
Cdd:COG0062   481 AAAALIALLLAAA 493
YXKO-related cd01171
B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of ...
 237-486 5.43e-79

B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.


Pssm-ID: 238576  Cd Length: 254  Bit Score: 247.14  E-value: 5.43e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281 237 RNTHKGESGRVLCVGGNLGSGGAIMLTAEAALRSGAGLVQVATRAEHVTPLLARCPEAMARA--MQADDDIATLAEAADA 314
Cdd:cd01171     1 PDSHKGSRGRVLVIGGSRGYTGAAYLAALAALRAGAGLVTVATPPEAAAVIKSYSPELMVHPllETDIEELLELLERADA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281 315 VALGPGLGQDAWAQALWRAALGAATAMVIDADGLNLLAANDVAARGPR--ILTPHPGEAGRLLGLSTRQIQRDRPAAAAA 392
Cdd:cd01171    81 VVIGPGLGRDEEAAEILEKALAKDKPLVLDADALNLLADEPSLIKRYGpvVLTPHPGEFARLLGALVEEIQADRLAAARE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281 393 LAKRYDAVVVLKGAGTVVASPGHLPRIIDAGNPGMAVGGMGDLLTGVIAALLAQGFSPFDAASLGALLHACAGDAAAHAG 472
Cdd:cd01171   161 AAAKLGATVVLKGAVTVIADPDGRVYVNPTGNPGLATGGSGDVLAGIIAALLAQGLSPLEAAALAVYLHGLAGDLAAKKK 240

                         250
                  ....*....|....
gi 1548924281 473 ERGLLPTDLLPELR 486
Cdd:cd01171   241 GAGLTAADLVAEIP 254
yjeF_cterm TIGR00196
yjeF C-terminal region, hydroxyethylthiazole kinase-related; E. coli yjeF has full-length ...
 223-490 2.90e-66

yjeF C-terminal region, hydroxyethylthiazole kinase-related; E. coli yjeF has full-length orthologs in a number of species, all of unknown function. However, yeast YNL200C is homologous and corresponds to the N-terminal region while yeast YKL151C and B. subtilis yxkO correspond to this C-terminal region only. The present model may hit hydroxyethylthiazole kinase, an enzyme associated with thiamine biosynthesis. [Unknown function, General]


Pssm-ID: 272955  Cd Length: 270  Bit Score: 214.56  E-value: 2.90e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281 223 WNGDAVAAQLRPRRRNTHKGESGRVLCVGGNLGSGGAIMLTAEAALRSGAGLVQVATRAEHVTPLLARCPEAMARA-MQA 301
Cdd:TIGR00196   3 FLGEGDLLTLPLRDPNSHKGQYGRVLIIGGSDDYSGAPLLAALAALRAGAGLVTVAAPENVITLINSVSPELIVHRlMWK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281 302 DDDIATLAEAADAVALGPGLGQDAWAQALWRAALGAATAMVIDADGLNLLAANDVAaRGPRILTPHPGEAGRLLGLStrQ 381
Cdd:TIGR00196  83 VDEDEELLERYDVVVIGPGLGQDPSFKKAVEEVLELDKPVVLDADALNLLTYNQKR-EGEVILTPHPGEFKRLLGVN--E 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281 382 IQRDRPAAAAALAKRYDAVVVLKGAGTVVASPGHLPRIIDAGNPGMAVGGMGDLLTGVIAALLAQGFSPFDAASLGALL- 460
Cdd:TIGR00196 160 IQGDRLEAAQDIAQKLQAVVVLKGAADVIAAPDGDLWINKTGNAALAKGGTGDVLAGLIGGLLAQNLDPFDAACNAAFAh 239

                         250       260       270
                  ....*....|....*....|....*....|
gi 1548924281 461 HACAGDAAAHAGERGLLPTDLLPELRRLAN 490
Cdd:TIGR00196 240 GLAGDLALKNHGAYGLTALDLIEKIPRVCK 269
Carb_kinase pfam01256
Carbohydrate kinase; This family is related to pfam02110 and pfam00294 implying that it also ...
 247-487 2.74e-54

Carbohydrate kinase; This family is related to pfam02110 and pfam00294 implying that it also is a carbohydrate kinase. (personal obs Yeats C).


Pssm-ID: 396007  Cd Length: 242  Bit Score: 182.56  E-value: 2.74e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281 247 VLCVGGNLGSGGAIMLTAEAALRSGAGLVQVATRAEHVTPLLARCPEAMARAMQADDDIATLAEAADAVALGPGLGQDAW 326
Cdd:pfam01256   1 VLVIGGSKDYTGAPLLAALAALRSGAGLVSVATDSEAIAVLKSPLPEVMVHPLPETSSILEKLSRYDAVVIGPGLGRDEK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281 327 AQALWRAALGAATAMVIDADGLNLLAANDVAA--RGPRILTPHPGEAGRLLGLSTrQIQRDRPAAAAALAKRYDAVVVLK 404
Cdd:pfam01256  81 GKAALEEVLAKDCPLVIDADALNLLAINNEKParEGPTVLTPHPGEFERLCGLAG-ILGDDRLEAARELAQKLNGTILLK 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281 405 GAGTVVASPGHLPRIIDAGNPGMAVGGMGDLLTGVIAALLAQGFSPFDAASLGALLHACAGDAAAHAGERGLLPTDLLPE 484
Cdd:pfam01256 160 GNVTVIAAPGGEVWINSTGNSALAKGGSGDVLAGLIGGLLAQNEDPYDAAIAAAWLHGAASDLAAENHGVYMLPTLLSKI 239


                  ...
gi 1548924281 485 LRR 487
Cdd:pfam01256 240 IPR 242
YjeF_N pfam03853
YjeF-related protein N-terminus; YjeF-N domain is a novel version of the Rossmann fold with a ...
 31-188 2.64e-40

YjeF-related protein N-terminus; YjeF-N domain is a novel version of the Rossmann fold with a set of catalytic residues and structural features that are different from the conventional dehydrogenases. YjeF-N domain is fused to Ribokinases in bacteria (YjeF), where they may be phosphatases, and to divergent Sm and the FDF domain in eukaryotes (Dcp3p and FLJ21128), where they may be involved in decapping and catalyze hydrolytic RNA-processing reactions.


Pssm-ID: 427546 [Multi-domain]  Cd Length: 168  Bit Score: 142.75  E-value: 2.64e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281  31 LMQRAGQAAWQWLLERW-PQARRIVVVCGTGNNGGDGYVLARLAHRAGRQVGVVHLPEHGPASDLAQRACTDYLAVGGAI 109
Cdd:pfam03853   4 LMENAGRAAARVLKALLsPAGPKVLILCGPGNNGGDGLAAARHLANRGAKVTVLLLGPEEKLSEDARRQLDLFKKLGGKI 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281 110 ------ELFPYPLAQADVIVDALFGIGLNRAPDDATAGLIDAINAADVPVFALDVPSGIDADHGVAFGAAVRAALTLQFI 183
Cdd:pfam03853  84 vtdnpdEDLEKLLSPVDLIIDALLGTGLSGPLRGEYAALIEWINQSGAPVLAVDIPSGLDADTGAVLGTAVRADHTVTFG 163


                  ....*
gi 1548924281 184 VPHLG 188
Cdd:pfam03853 164 APKPG 168
yjeF_nterm TIGR00197
yjeF N-terminal region; The protein region corresponding to this model shows no clear homology ...
 10-209 1.84e-39

yjeF N-terminal region; The protein region corresponding to this model shows no clear homology to any protein of known function. This model is built on yeast protein YNL200C and the N-terminal regions of E. coli yjeF and its orthologs in various species. The C-terminal region of yjeF and its orthologs shows similarity to hydroxyethylthiazole kinase (thiM) and other enzymes involved in thiamine biosynthesis. Yeast YKL151C and B. subtilis yxkO match the yjeF C-terminal domain but lack this region. [Unknown function, General]


Pssm-ID: 272956 [Multi-domain]  Cd Length: 205  Bit Score: 141.78  E-value: 1.84e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281  10 TAAARTLDAQATTLLGGDGYTLMQRAGQAAWQWLLERWPQARRIVVVCGTGNNGGDGYVLARLAHRAGRQVGVVHLPEHG 89
Cdd:TIGR00197   5 SPKDMAIDKENAEYLGLTLDLLMENAGKAVAQAVLQAYPLAGHVIIFCGPGNNGGDGFVVARHLKGFGVEVFLLKKEKRI 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281  90 PASDLAQRACTDYLAVGGAIELFPYP-LAQADVIVDALFGIGLNRAPDDATAGLIDAINAADVPVFALDVPSGIDADHGV 168
Cdd:TIGR00197  85 ECTEQAEVNLKALKVGGISIDEGNLVkPEDCDVIIDAILGTGFKGKLREPFKTIVESINELPAPIVSVDIPSGLDVDTGA 164

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1548924281 169 AFGAAVRAALTLQFIVPHLGLYTGDAlEHAGEREVASLEVP 209
Cdd:TIGR00197 165 IEGPAVNADLTITFHAIKPCLLSDRA-DVTGELKVGGIGIP 204
PLN03050 PLN03050
pyridoxine (pyridoxamine) 5'-phosphate oxidase; Provisional
 5-188 4.26e-18

pyridoxine (pyridoxamine) 5'-phosphate oxidase; Provisional


Pssm-ID: 215551 [Multi-domain]  Cd Length: 246  Bit Score: 83.77  E-value: 4.26e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281   5 LALYDTAAARTLDAQattLLGGDGYT---LMQRAG----QAAWQWLLERWPQA-----RRIVVVCGTGNNGGDGYVLAR- 71
Cdd:PLN03050    6 TGYLNAQDAAALDEE---LMSTPGFSleqLMELAGlsvaEAVYEVADGEKASNppgrhPRVLLVCGPGNNGGDGLVAARh 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281  72 LAHrAGRQVGVVHLPEHG-PASDLAQRACTD----YLAVGGAIELFPYPLAQA-DVIVDALFGI---GLNRAPDDATAGL 142
Cdd:PLN03050   83 LAH-FGYEVTVCYPKQSSkPHYENLVTQCEDlgipFVQAIGGTNDSSKPLETTyDVIVDAIFGFsfhGAPRAPFDTLLAQ 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1548924281 143 IDAINAADVPVFALDVPSGIDADHGVAFGAAVRAALTLQFIVPHLG 188
Cdd:PLN03050  162 MVQQQKSPPPIVSVDVPSGWDVDEGDVSGTGMRPDVLVSLTAPKLS 207
PLN03049 PLN03049
pyridoxine (pyridoxamine) 5'-phosphate oxidase; Provisional
 22-187 1.73e-13

pyridoxine (pyridoxamine) 5'-phosphate oxidase; Provisional


Pssm-ID: 215550 [Multi-domain]  Cd Length: 462  Bit Score: 72.19  E-value: 1.73e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281  22 TLLGGDGYT---LMQRAGQAAWQWLLERWP--QARRIVVVCGTGNNGGDGYVLARLAHRAGRQVGVVHlPEHGPASdLAQ 96
Cdd:PLN03049   26 HLMGPLGFSvdqLMELAGLSVASAIAEVYSpsEYRRVLALCGPGNNGGDGLVAARHLHHFGYKPSICY-PKRTDKP-LYN 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281  97 RACTDYLAVGG---AIELFPYPLA-QADVIVDALFGI---GLNRAP-DDATAGLIDAINAAdvPVFALDVPSGIDADHGV 168
Cdd:PLN03049  104 GLVTQLESLSVpflSVEDLPSDLSsQFDIVVDAMFGFsfhGAPRPPfDDLIQKLVRAAGPP--PIVSVDIPSGWHVEEGD 181

                         170
                  ....*....|....*....
gi 1548924281 169 AFGAAVRAALTLQFIVPHL 187
Cdd:PLN03049  182 VNGEGLKPDMLVSLTAPKL 200
PLN02918 PLN02918
pyridoxine (pyridoxamine) 5'-phosphate oxidase
 22-187 7.64e-10

pyridoxine (pyridoxamine) 5'-phosphate oxidase


Pssm-ID: 215496 [Multi-domain]  Cd Length: 544  Bit Score: 61.11  E-value: 7.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281  22 TLLGGDGYT---LMQRAGQAAWQWLLERWP--QARRIVVVCGTGNNGGDGYVLARLAHRAGRQVGVVHlPEHGPASdLAQ 96
Cdd:PLN02918  102 TLMGPLGFSvdqLMELAGLSVAASIAEVYKpgEYSRVLAICGPGNNGGDGLVAARHLHHFGYKPFVCY-PKRTAKP-LYT 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281  97 RACT--DYLAVGG-AIELFPYPLAQA-DVIVDALFGIGLNRAPDDATAGLIDAI-------NAADVPVF-ALDVPSGIDA 164
Cdd:PLN02918  180 GLVTqlESLSVPFvSVEDLPADLSKDfDIIVDAMFGFSFHGAPRPPFDDLIRRLvslqnyeQTLKHPVIvSVDIPSGWHV 259

                         170       180
                  ....*....|....*....|...
gi 1548924281 165 DHGVAFGAAVRAALTLQFIVPHL 187
Cdd:PLN02918  260 EEGDHEGGGIKPDMLVSLTAPKL 282
PksD COG3321
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ...
 109-495 1.32e-04

Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442550 [Multi-domain]  Cd Length: 1386  Bit Score: 44.86  E-value: 1.32e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281  109 IELFPYPLAQADVIVDALFGIGLNRAPDDATAGLIDAINAADVPVFALDVPSGI-----------DADHGVAFGAAVRAA 177
Cdd:COG3321    861 VPLPTYPFQREDAAAALLAAALAAALAAAAALGALLLAALAAALAAALLALAAAaaaalalaaaaLAALLALVALAAAAA 940

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281  178 LTLQFIVPHLGLYTGDALEHAGEREVASLEVPVSAFDGLAPAAHGWNGDAVAAQLRPRRRNTHKGESGRVLCVGGNLGSG 257
Cdd:COG3321    941 ALLALAAAAAAAAAALAAAEAGALLLLAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAALALLAAAALLLAAAAAAAA 1020

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281  258 GAIMLTAEAALRSGAGLVQVATRAEHVTPLLARCPEAMARAMQADDDIATLAEAADAVALGPGLGQDAWAQALWRAALGA 337
Cdd:COG3321   1021 LLALAALLAAAAAALAAAAAAAAAAAALAALAAAAAAAAALALALAALLLLAALAELALAAAALALAAALAAAALALALA 1100

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1548924281  338 ATAMVIDADGLNLLAANDVAARGPRILTPHPGEAGRLLGLSTRQIQRDRPAAAAALAKRYDAVVVLKGAGTVVASPGHLP 417
Cdd:COG3321   1101 ALAAALLLLALLAALALAAAAAALLALAALLAAAAAAAALAAAAAAAAALALAAAAAALAAALAAALLAAAALLLALALA 1180

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1548924281  418 RIIDAGNPGMAVGGMGDLLTGVIAALLAQGFSPFDAASLGALLHACAGDAAAHAGERGLLPTDLLPELRRLANAGAIA 495
Cdd:COG3321   1181 LAAALAAALAGLAALLLAALLAALLAALLALALAALAAAAAALLAAAAAAAALALLALAAAAAAVAALAAAAAALLAA 1258
THZ_kinase cd01170
4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the ...
 395-460 1.79e-04

4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine and 1-deoxy-D-xylulose-5-phosphate.


Pssm-ID: 238575 [Multi-domain]  Cd Length: 242  Bit Score: 42.91  E-value: 1.79e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1548924281 395 KRYDAVVVLKGAGTVVASPGHLpRIIDAGNPGMA-VGGMGDLLTGVIAALLAQGFSPFDAAsLGALL 460
Cdd:cd01170   150 RKYGAVVVVTGEVDYITDGERV-VVVKNGHPLLTkITGTGCLLGAVIAAFLAVGDDPLEAA-VSAVL 214
PRK09355 PRK09355
hydroxyethylthiazole kinase; Validated
 395-454 1.98e-03

hydroxyethylthiazole kinase; Validated


Pssm-ID: 236477 [Multi-domain]  Cd Length: 263  Bit Score: 40.17  E-value: 1.98e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1548924281 395 KRYDAVVVLKGAGTVVASpGHLPRIIDAGNPGMA-VGGMGDLLTGVIAALLAQGFSPFDAA 454
Cdd:PRK09355  154 KKYGTVVVVTGEVDYITD-GERVVSVHNGHPLMTkVTGTGCLLSAVVAAFAAVEKDYLEAA 213
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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