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Conserved domains on  [gi|1547596089|gb|AZT84517|]
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DHH family phosphoesterase [Marinobacter sp. NP-4(2019)]

Protein Classification

DHH family phosphoesterase( domain architecture ID 10475496)

DHH family phosphoesterase such as the ssDNA exonuclease RecJ, a specific 5'-3' exonuclease, or the bifunctional oligoribonuclease and PAP phosphatase NrnA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DHHA1 pfam02272
DHHA1 domain; This domain is often found adjacent to the DHH domain pfam01368 and is called ...
 200-318 4.10e-08

DHHA1 domain; This domain is often found adjacent to the DHH domain pfam01368 and is called DHHA1 for DHH associated domain. This domain is diagnostic of DHH subfamily 1 members. This domains is also found in alanyl tRNA synthetase, suggesting that this domain may have an RNA binding function. The domain is about 60 residues long and contains a conserved GG motif.


:

Pssm-ID: 396724 [Multi-domain]  Cd Length: 139  Bit Score: 51.29  E-value: 4.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547596089 200 QKLRDGYEADMASGLAAPVLAENGASLVVQLPDEPWARRVSGVLGNELANRNPDKACAIVTVKADGSYLVSIRAPLNNRT 279
Cdd:pfam02272  16 EELKEALALLKAKELLEKAEEINGVKVLVAEVGEGWDAGALGIAADRLKKKLGDPVIVLVAKEDGDKVKVSARSSKDKGV 95

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1547596089 280 GADELARRFPT-----GGGRKAAAGINaLPAEQLDEFLEAVAAF 318
Cdd:pfam02272  96 DAGELLKEVAAilgggGGGHDLAAGAG-IDAEKLDEALELLEEA 138
DHH pfam01368
DHH family; It is predicted that this family of proteins all perform a phosphoesterase ...
 7-90 4.40e-03

DHH family; It is predicted that this family of proteins all perform a phosphoesterase function. It included the single stranded DNA exonuclease RecJ.


:

Pssm-ID: 460177 [Multi-domain]  Cd Length: 145  Bit Score: 37.17  E-value: 4.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547596089   7 FNGDADGVCALIQL-----RLANP-VESTLITGVKRDIELAKQVpVTEPAQVNILDVSLDTN---REAVDALLSTGSSVF 77
Cdd:pfam01368   8 YNPDGDGIGSALGLyrylkELVGPdVEYYIPDRLEEGYGINPEA-IEELIDFDTLLITVDCGiksVEGIELAKELGIDVI 86

                          90
                  ....*....|...
gi 1547596089  78 YVDHHFPGDSLPQ 90
Cdd:pfam01368  87 VIDHHLPNDFLPD 99
 
Name Accession Description Interval E-value
DHHA1 pfam02272
DHHA1 domain; This domain is often found adjacent to the DHH domain pfam01368 and is called ...
 200-318 4.10e-08

DHHA1 domain; This domain is often found adjacent to the DHH domain pfam01368 and is called DHHA1 for DHH associated domain. This domain is diagnostic of DHH subfamily 1 members. This domains is also found in alanyl tRNA synthetase, suggesting that this domain may have an RNA binding function. The domain is about 60 residues long and contains a conserved GG motif.


Pssm-ID: 396724 [Multi-domain]  Cd Length: 139  Bit Score: 51.29  E-value: 4.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547596089 200 QKLRDGYEADMASGLAAPVLAENGASLVVQLPDEPWARRVSGVLGNELANRNPDKACAIVTVKADGSYLVSIRAPLNNRT 279
Cdd:pfam02272  16 EELKEALALLKAKELLEKAEEINGVKVLVAEVGEGWDAGALGIAADRLKKKLGDPVIVLVAKEDGDKVKVSARSSKDKGV 95

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1547596089 280 GADELARRFPT-----GGGRKAAAGINaLPAEQLDEFLEAVAAF 318
Cdd:pfam02272  96 DAGELLKEVAAilgggGGGHDLAAGAG-IDAEKLDEALELLEEA 138
DHH pfam01368
DHH family; It is predicted that this family of proteins all perform a phosphoesterase ...
 7-90 4.40e-03

DHH family; It is predicted that this family of proteins all perform a phosphoesterase function. It included the single stranded DNA exonuclease RecJ.


Pssm-ID: 460177 [Multi-domain]  Cd Length: 145  Bit Score: 37.17  E-value: 4.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547596089   7 FNGDADGVCALIQL-----RLANP-VESTLITGVKRDIELAKQVpVTEPAQVNILDVSLDTN---REAVDALLSTGSSVF 77
Cdd:pfam01368   8 YNPDGDGIGSALGLyrylkELVGPdVEYYIPDRLEEGYGINPEA-IEELIDFDTLLITVDCGiksVEGIELAKELGIDVI 86

                          90
                  ....*....|...
gi 1547596089  78 YVDHHFPGDSLPQ 90
Cdd:pfam01368  87 VIDHHLPNDFLPD 99
 
Name Accession Description Interval E-value
DHHA1 pfam02272
DHHA1 domain; This domain is often found adjacent to the DHH domain pfam01368 and is called ...
 200-318 4.10e-08

DHHA1 domain; This domain is often found adjacent to the DHH domain pfam01368 and is called DHHA1 for DHH associated domain. This domain is diagnostic of DHH subfamily 1 members. This domains is also found in alanyl tRNA synthetase, suggesting that this domain may have an RNA binding function. The domain is about 60 residues long and contains a conserved GG motif.


Pssm-ID: 396724 [Multi-domain]  Cd Length: 139  Bit Score: 51.29  E-value: 4.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547596089 200 QKLRDGYEADMASGLAAPVLAENGASLVVQLPDEPWARRVSGVLGNELANRNPDKACAIVTVKADGSYLVSIRAPLNNRT 279
Cdd:pfam02272  16 EELKEALALLKAKELLEKAEEINGVKVLVAEVGEGWDAGALGIAADRLKKKLGDPVIVLVAKEDGDKVKVSARSSKDKGV 95

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1547596089 280 GADELARRFPT-----GGGRKAAAGINaLPAEQLDEFLEAVAAF 318
Cdd:pfam02272  96 DAGELLKEVAAilgggGGGHDLAAGAG-IDAEKLDEALELLEEA 138
DHH pfam01368
DHH family; It is predicted that this family of proteins all perform a phosphoesterase ...
 7-90 4.40e-03

DHH family; It is predicted that this family of proteins all perform a phosphoesterase function. It included the single stranded DNA exonuclease RecJ.


Pssm-ID: 460177 [Multi-domain]  Cd Length: 145  Bit Score: 37.17  E-value: 4.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547596089   7 FNGDADGVCALIQL-----RLANP-VESTLITGVKRDIELAKQVpVTEPAQVNILDVSLDTN---REAVDALLSTGSSVF 77
Cdd:pfam01368   8 YNPDGDGIGSALGLyrylkELVGPdVEYYIPDRLEEGYGINPEA-IEELIDFDTLLITVDCGiksVEGIELAKELGIDVI 86

                          90
                  ....*....|...
gi 1547596089  78 YVDHHFPGDSLPQ 90
Cdd:pfam01368  87 VIDHHLPNDFLPD 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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