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Conserved domains on  [gi|1547055316|ref|NP_001798|]
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bile salt-activated lipase precursor [Homo sapiens]

Protein Classification

Esterase_lipase and Mucin-like domain-containing protein( domain architecture ID 11987879)

Esterase_lipase and Mucin-like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
26-542 0e+00

Carboxylesterase family;


:

Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 623.18  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  26 VYTEGGFVEGVNKKLGLlGDSVDIFKGIPFAAPTKAL---ENPQPHPGWQGTLKAKNFKKRCLQATITQDSTY----GDE 98
Cdd:pfam00135   5 VTTSLGRVRGKRLKVDG-GKPVYAFLGIPYAEPPVGElrfQPPEPPEPWTGVRDATKFGPRCPQNGDLTSPGSsgleGSE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  99 DCLYLNIWVPQGRKQVSRDLPVMIWIYGGAFLMGSGHganflnnyLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANL 178
Cdd:pfam00135  84 DCLYLNVYTPKELKENKNKLPVMVWIHGGGFMFGSGS--------LYDGSYLAAEGDVIVVTINYRLGPLGFLSTGDDEA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 179 PGNYGLRDQHMAIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQSGVALSPWVIQKNPLFWAK 258
Cdd:pfam00135 156 PGNYGLLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLSPLSKGLFHRAILMSGSALSPWAIQSNARQRAK 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 259 KVAEKVGCPVGDAARMAQCLKVTDPRALTLAYKVPlagLEYPMLHYVGFVPVIDGDFIPADPINLYA--NAADIDYIAGT 336
Cdd:pfam00135 236 ELAKLVGCPTSDSAELVECLRSKPAEELLDAQLKL---LVYGSVPFVPFGPVVDGDFLPEHPEELLKsgNFPKVPLLIGV 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 337 NNMDGHIFASIDMPAINKGNKKVTEEDFYKLVSEFTITKGL---RGAKTTFDVYTEsWAQDPSQENKKKTVVDFETDVLF 413
Cdd:pfam00135 313 TKDEGLLFAAYILDNVDILKALEEKLLRSLLIDLLYLLLVDlpeEISAALREEYLD-WGDRDDPETSRRALVELLTDYLF 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 414 LVPTEIALAQHRanAKSAKTYAYLFSHPSRMPVYPKWVGADHADDIQYVFGKPFATPTGYRPQDRTVSKAMIAYWTNFAK 493
Cdd:pfam00135 392 NCPVIRFADLHA--SRGTPVYMYSFDYRGSSLRYPKWVGVDHGDELPYVFGTPFVGALLFTEEDEKLSRKMMTYWTNFAK 469

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*....
gi 1547055316 494 TGDPNMGdsAVPTHWEPYTTENSGYLEITKKMgssSMKRSLRTNFLRYW 542
Cdd:pfam00135 470 TGNPNGP--EGLPKWPPYTDENGQYLSIDLEP---RVKQGLKAERCAFW 513
Mucin-like pfam16058
Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated ...
 584-677 5.44e-22

Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated lipase, where is O-glycosylated. This region is composed of biased amino acid composition that is likely to be disordered. The region contains many repeats of an approximately 11 residue degenerate repeat.


:

Pssm-ID: 464997 [Multi-domain]  Cd Length: 94  Bit Score: 90.94  E-value: 5.44e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 584 PTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTG 663
Cdd:pfam16058   1 PSSSITEPPRDPSGSYGEPPRAPSSSYTEPQRDPSSSITEPPADPSSSYTEPPRDPSGSYTEPQRDPSSSSTEPQRDPSS 80

                          90
                  ....*....|....
gi 1547055316 664 DSGAPPVPPTGDAG 677
Cdd:pfam16058  81 SITEPPRDPSGSYT 94
Mucin-like pfam16058
Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated ...
 639-731 1.77e-20

Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated lipase, where is O-glycosylated. This region is composed of biased amino acid composition that is likely to be disordered. The region contains many repeats of an approximately 11 residue degenerate repeat.


:

Pssm-ID: 464997 [Multi-domain]  Cd Length: 94  Bit Score: 86.71  E-value: 1.77e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 639 PTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTG 718
Cdd:pfam16058   1 PSSSITEPPRDPSGSYGEPPRAPSSSYTEPQRDPSSSITEPPADPSSSYTEPPRDPSGSYTEPQRDPSSSSTEPQRDPSS 80

                          90
                  ....*....|...
gi 1547055316 719 DSGAPPVPPTGDS 731
Cdd:pfam16058  81 SITEPPRDPSGSY 93
 
Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
26-542 0e+00

Carboxylesterase family;


Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 623.18  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  26 VYTEGGFVEGVNKKLGLlGDSVDIFKGIPFAAPTKAL---ENPQPHPGWQGTLKAKNFKKRCLQATITQDSTY----GDE 98
Cdd:pfam00135   5 VTTSLGRVRGKRLKVDG-GKPVYAFLGIPYAEPPVGElrfQPPEPPEPWTGVRDATKFGPRCPQNGDLTSPGSsgleGSE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  99 DCLYLNIWVPQGRKQVSRDLPVMIWIYGGAFLMGSGHganflnnyLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANL 178
Cdd:pfam00135  84 DCLYLNVYTPKELKENKNKLPVMVWIHGGGFMFGSGS--------LYDGSYLAAEGDVIVVTINYRLGPLGFLSTGDDEA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 179 PGNYGLRDQHMAIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQSGVALSPWVIQKNPLFWAK 258
Cdd:pfam00135 156 PGNYGLLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLSPLSKGLFHRAILMSGSALSPWAIQSNARQRAK 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 259 KVAEKVGCPVGDAARMAQCLKVTDPRALTLAYKVPlagLEYPMLHYVGFVPVIDGDFIPADPINLYA--NAADIDYIAGT 336
Cdd:pfam00135 236 ELAKLVGCPTSDSAELVECLRSKPAEELLDAQLKL---LVYGSVPFVPFGPVVDGDFLPEHPEELLKsgNFPKVPLLIGV 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 337 NNMDGHIFASIDMPAINKGNKKVTEEDFYKLVSEFTITKGL---RGAKTTFDVYTEsWAQDPSQENKKKTVVDFETDVLF 413
Cdd:pfam00135 313 TKDEGLLFAAYILDNVDILKALEEKLLRSLLIDLLYLLLVDlpeEISAALREEYLD-WGDRDDPETSRRALVELLTDYLF 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 414 LVPTEIALAQHRanAKSAKTYAYLFSHPSRMPVYPKWVGADHADDIQYVFGKPFATPTGYRPQDRTVSKAMIAYWTNFAK 493
Cdd:pfam00135 392 NCPVIRFADLHA--SRGTPVYMYSFDYRGSSLRYPKWVGVDHGDELPYVFGTPFVGALLFTEEDEKLSRKMMTYWTNFAK 469

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*....
gi 1547055316 494 TGDPNMGdsAVPTHWEPYTTENSGYLEITKKMgssSMKRSLRTNFLRYW 542
Cdd:pfam00135 470 TGNPNGP--EGLPKWPPYTDENGQYLSIDLEP---RVKQGLKAERCAFW 513
Esterase_lipase cd00312
Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on ...
 25-532 0e+00

Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These catalytic residues are responsible for the nucleophilic attack on the carbonyl carbon atom of the ester bond. In contrast with other alpha/beta hydrolase fold family members, p-nitrobenzyl esterase and acetylcholine esterase have a Glu instead of Asp at the active site carboxylate.


Pssm-ID: 238191 [Multi-domain]  Cd Length: 493  Bit Score: 573.51  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  25 AVYTEGGFVEGVNKklgllgDSVDIFKGIPFAAPT---KALENPQPHPGWQGTLKAKNFKKRCLQATITQDS-----TYG 96
Cdd:cd00312     1 LVVTPNGKVRGVDE------GGVYSFLGIPYAEPPvgdLRFKEPQPYEPWSDVLDATSYPPSCMQWDQLGGGlwnakLPG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  97 DEDCLYLNIWVPQGRKqVSRDLPVMIWIYGGAFLMGSGHganflnnyLYDGEEIATRG-NVIVVTFNYRVGPLGFLSTGD 175
Cdd:cd00312    75 SEDCLYLNVYTPKNTK-PGNSLPVMVWIHGGGFMFGSGS--------LYPGDGLAREGdNVIVVSINYRLGVLGFLSTGD 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 176 ANLPGNYGLRDQHMAIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQSGVALSPWVIQKNPLF 255
Cdd:cd00312   146 IELPGNYGLKDQRLALKWVQDNIAAFGGDPDSVTIFGESAGGASVSLLLLSPDSKGLFHRAISQSGSALSPWAIQENARG 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 256 WAKKVAEKVGCPVGDAARMAQCLKVTDPRALTLAYKVPlagLEYPMLHYVGFVPVIDGDFIPADPINLYA--NAADIDYI 333
Cdd:cd00312   226 RAKRLARLLGCNDTSSAELLDCLRSKSAEELLDATRKL---LLFSYSPFLPFGPVVDGDFIPDDPEELIKegKFAKVPLI 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 334 AGTNNMDGHIFASIDMPAINKgNKKVTEEDFYKLVSEFTITKGLRGAKTTFDVYTESWAQdpsQENKKKTVVDFETDVLF 413
Cdd:cd00312   303 IGVTKDEGGYFAAMLLNFDAK-LIIETNDRWLELLPYLLFYADDALADKVLEKYPGDVDD---SVESRKNLSDMLTDLLF 378

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 414 LVPTEIALAQHRANAKSaKTYAYLFSHPSRMPV--YPKWVGADHADDIQYVFGKPFATPTGYrPQDRTVSKAMIAYWTNF 491
Cdd:cd00312   379 KCPARYFLAQHRKAGGS-PVYAYVFDHRSSLSVgrWPPWLGTVHGDEIFFVFGNPLLKEGLR-EEEEKLSRTMMKYWANF 456

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|.
gi 1547055316 492 AKTGDPNMGDsaVPTHWEPYTTENSGYLEITkkMGSSSMKR 532
Cdd:cd00312   457 AKTGNPNTEG--NLVVWPAYTSESEKYLDIN--IEGTEIKQ 493
PnbA COG2272
Carboxylesterase type B [Lipid transport and metabolism];
26-521 2.41e-127

Carboxylesterase type B [Lipid transport and metabolism];


Pssm-ID: 441873  Cd Length: 500  Bit Score: 388.48  E-value: 2.41e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  26 VYTEGGFVEGVnkklglLGDSVDIFKGIPFAAPT------KAlenPQPHPGWQGTLKAKNFKKRCLQATITQD---STYG 96
Cdd:COG2272    15 VRTEAGRVRGV------VEGGVRVFLGIPYAAPPvgelrwRA---PQPVEPWTGVRDATEFGPACPQPPRPGDpggPAPG 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  97 DEDCLYLNIWVPqgRKQVSRDLPVMIWIYGGAFLMGSGHGAnflnnyLYDGEEIATRGnVIVVTFNYRVGPLGF-----L 171
Cdd:COG2272    86 SEDCLYLNVWTP--ALAAGAKLPVMVWIHGGGFVSGSGSEP------LYDGAALARRG-VVVVTINYRLGALGFlalpaL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 172 STGDANLPGNYGLRDQHMAIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQSGVAL---SPWV 248
Cdd:COG2272   157 SGESYGASGNYGLLDQIAALRWVRDNIAAFGGDPDNVTIFGESAGAASVAALLASPLAKGLFHRAIAQSGAGLsvlTLAE 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 249 IQKnplfWAKKVAEKVGCPVGDAArmaqCLKVTDPRALTLAYKVPLAGLEYPMlhyvGFVPVIDGDFIPADPINLYAN-- 326
Cdd:COG2272   237 AEA----VGAAFAAALGVAPATLA----ALRALPAEELLAAQAALAAEGPGGL----PFGPVVDGDVLPEDPLEAFAAgr 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 327 AADIDYIAGTNNMDGHIFASIDMPAinkgnKKVTEEDFyklvsEFTITKGLRG-AKTTFDVYTESWAQDpsqenkkkTVV 405
Cdd:COG2272   305 AADVPLLIGTNRDEGRLFAALLGDL-----GPLTAADY-----RAALRRRFGDdADEVLAAYPAASPAE--------ALA 366

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 406 DFETDVLFLVPTeIALAQHRAnAKSAKTYAYLFSHPSRMPVYPKWvGADHADDIQYVFGKPFA-TPTGYRPQDRTVSKAM 484
Cdd:COG2272   367 ALATDRVFRCPA-RRLAEAHA-AAGAPVYLYRFDWRSPPLRGFGL-GAFHGAELPFVFGNLDApALTGLTPADRALSDQM 443

                         490       500       510
                  ....*....|....*....|....*....|....*..
gi 1547055316 485 IAYWTNFAKTGDPNMGDsavPTHWEPYTTENSGYLEI 521
Cdd:COG2272   444 QAYWVNFARTGDPNGPG---LPEWPAYDPEDRAVMVF 477
Mucin-like pfam16058
Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated ...
 584-677 5.44e-22

Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated lipase, where is O-glycosylated. This region is composed of biased amino acid composition that is likely to be disordered. The region contains many repeats of an approximately 11 residue degenerate repeat.


Pssm-ID: 464997 [Multi-domain]  Cd Length: 94  Bit Score: 90.94  E-value: 5.44e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 584 PTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTG 663
Cdd:pfam16058   1 PSSSITEPPRDPSGSYGEPPRAPSSSYTEPQRDPSSSITEPPADPSSSYTEPPRDPSGSYTEPQRDPSSSSTEPQRDPSS 80

                          90
                  ....*....|....
gi 1547055316 664 DSGAPPVPPTGDAG 677
Cdd:pfam16058  81 SITEPPRDPSGSYT 94
Mucin-like pfam16058
Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated ...
 639-731 1.77e-20

Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated lipase, where is O-glycosylated. This region is composed of biased amino acid composition that is likely to be disordered. The region contains many repeats of an approximately 11 residue degenerate repeat.


Pssm-ID: 464997 [Multi-domain]  Cd Length: 94  Bit Score: 86.71  E-value: 1.77e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 639 PTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTG 718
Cdd:pfam16058   1 PSSSITEPPRDPSGSYGEPPRAPSSSYTEPQRDPSSSITEPPADPSSSYTEPPRDPSGSYTEPQRDPSSSSTEPQRDPSS 80

                          90
                  ....*....|...
gi 1547055316 719 DSGAPPVPPTGDS 731
Cdd:pfam16058  81 SITEPPRDPSGSY 93
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 556-749 2.51e-19

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 93.13  E-value: 2.51e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 556 EATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAP 635
Cdd:PRK07764  599 GPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAP 678

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 636 PVPPTGDSGAPPVPPTGDSGAPPVPpTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPptgdSGAPPVTPTGDSETAPVP 715
Cdd:PRK07764  679 AAPPPAPAPAAPAAPAGAAPAQPAP-APAATPPAGQADDPAAQPPQAAQGASAPSPAA----DDPVPLPPEPDDPPDPAG 753

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1547055316 716 PTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMPA 749
Cdd:PRK07764  754 APAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAE 787
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 558-739 5.39e-15

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 78.66  E-value: 5.39e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 558 TPVPPTGDSEATPVP---PTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGA 634
Cdd:NF033839  283 TPKEPGNKKPSAPKPgmqPSPQPEKKEVKPEPETPKPEVKPQLEKPKPEVKPQPEKPKPEVKPQLETPKPEVKPQPEKPK 362

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 635 PPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTP---TGDSET 711
Cdd:NF033839  363 PEVKPQPEKPKPEVKPQPETPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPqpeKPKPEV 442

                         170       180
                  ....*....|....*....|....*...
gi 1547055316 712 APVPPTGDSGAPPVPPTGDSEAAPVPPT 739
Cdd:NF033839  443 KPQPEKPKPEVKPQPETPKPEVKPQPEK 470
PHA03247 PHA03247
large tegument protein UL36; Provisional
 568-748 1.48e-14

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 78.06  E-value: 1.48e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  568 ATPVPPTGDSETAPVPPTGDSGAPPVPPTgdsgAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGdsgapP 647
Cdd:PHA03247  2678 SPPQRPRRRAARPTVGSLTSLADPPPPPP----TPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAG-----P 2748

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  648 VPPTGDSgAPPVPPTGDSGAPPVPPTGDAGPPP---VPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPP 724
Cdd:PHA03247  2749 ATPGGPA-RPARPPTTAGPPAPAPPAAPAAGPPrrlTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGP 2827

                          170       180
                   ....*....|....*....|....
gi 1547055316  725 VPPTGDSEAAPVPPTDDSKEAQMP 748
Cdd:PHA03247  2828 LPPPTSAQPTAPPPPPGPPPPSLP 2851
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 564-748 1.67e-14

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 77.12  E-value: 1.67e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 564 GDSEATPVPPTGDSETAPVP---PTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPT 640
Cdd:NF033839  278 GLTQDTPKEPGNKKPSAPKPgmqPSPQPEKKEVKPEPETPKPEVKPQLEKPKPEVKPQPEKPKPEVKPQLETPKPEVKPQ 357

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 641 GDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTP---TGDSETAPVPPT 717
Cdd:NF033839  358 PEKPKPEVKPQPEKPKPEVKPQPETPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPqpeKPKPEVKPQPEK 437

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1547055316 718 GDSGAPPVPPTGDSEAAPVPPTDDSKEAQMP 748
Cdd:NF033839  438 PKPEVKPQPEKPKPEVKPQPETPKPEVKPQP 468
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 550-743 5.22e-11

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 65.95  E-value: 5.22e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 550 PTVTDQEATPVPP------TGDSEATPVPPTGDSETAPVPPTGDsgaPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGA 623
Cdd:NF033839  297 PGMQPSPQPEKKEvkpepeTPKPEVKPQLEKPKPEVKPQPEKPK---PEVKPQLETPKPEVKPQPEKPKPEVKPQPEKPK 373

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 624 PPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPV 703
Cdd:NF033839  374 PEVKPQPETPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEV 453

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1547055316 704 TPTGDSETAPVPPTGDSGAPPVPPTGDseaapVPPTDDSK 743
Cdd:NF033839  454 KPQPETPKPEVKPQPEKPKPEVKPQPE-----KPKPDNSK 488
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 625-734 1.28e-08

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 58.28  E-value: 1.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 625 PVPPtgdsgAPPVPPTGDSGAPPVPPTGDSGAPPVPPTgdSGAPPVPPTGDAGPPPVPPTgDSGAPPVPPTgdsgaPPVT 704
Cdd:PRK14950  362 PVPA-----PQPAKPTAAAPSPVRPTPAPSTRPKAAAA--ANIPPKEPVRETATPPPVPP-RPVAPPVPHT-----PESA 428

                          90       100       110
                  ....*....|....*....|....*....|
gi 1547055316 705 PTGDSETAPVPPTGDSGAPPVPPTGDSEAA 734
Cdd:PRK14950  429 PKLTRAAIPVDEKPKYTPPAPPKEEEKALI 458
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 558-693 3.63e-08

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 55.93  E-value: 3.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 558 TPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPV 637
Cdd:NF040712  200 ATVPRLAREPADARPEEVEPAPAAEGAPATDSDPAEAGTPDDLASARRRRAGVEQPEDEPVGPGAAPAAEPDEATRDAGE 279

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1547055316 638 PPTGDSGAPPVP--PTGDSGAPPVPPTGDSGAPPVPPtgdAGPPPVPPTGDSGAPPVP 693
Cdd:NF040712  280 PPAPGAAETPEAaePPAPAPAAPAAPAAPEAEEPARP---EPPPAPKPKRRRRRASVP 334
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 566-715 1.33e-07

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 54.39  E-value: 1.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 566 SEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPV-PPTGDSGAPPVPPTGDSG 644
Cdd:NF040712  188 IDPDFGRPLRPLATVPRLAREPADARPEEVEPAPAAEGAPATDSDPAEAGTPDDLASARRRrAGVEQPEDEPVGPGAAPA 267

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1547055316 645 APPVPPTGDSGAPPVPPTGDSGAPPvPPTGDAGPPPVPPTGDSGAPPVPPtgdSGAPPVTPTGDSETAPVP 715
Cdd:NF040712  268 AEPDEATRDAGEPPAPGAAETPEAA-EPPAPAPAAPAAPAAPEAEEPARP---EPPPAPKPKRRRRRASVP 334
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 590-741 3.48e-07

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 52.85  E-value: 3.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 590 APPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPtgDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPP 669
Cdd:NF040712  193 GRPLRPLATVPRLAREPADARPEEVEPAPAAEGAPATDS--DPAEAGTPDDLASARRRRAGVEQPEDEPVGPGAAPAAEP 270

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1547055316 670 VPPTGDAGPPPVPPTGDSGAPPvPPTGDSGAPPVTPTGDSETAPVPPtgdSGAPPVPPTGDSEAAPVPPTDD 741
Cdd:NF040712  271 DEATRDAGEPPAPGAAETPEAA-EPPAPAPAAPAAPAAPEAEEPARP---EPPPAPKPKRRRRRASVPSWDD 338
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 556-708 3.97e-07

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 52.85  E-value: 3.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 556 EATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPV-PPTGDSGAPPVPPTGDSGA 634
Cdd:NF040712  189 DPDFGRPLRPLATVPRLAREPADARPEEVEPAPAAEGAPATDSDPAEAGTPDDLASARRRrAGVEQPEDEPVGPGAAPAA 268

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1547055316 635 PPVPPTGDSGAPPVPPTGDSGAPPvPPTGDSGAPPVPPTGDAGPPPVPPtgdsGAPPVPPTGDSGAPPVTPTGD 708
Cdd:NF040712  269 EPDEATRDAGEPPAPGAAETPEAA-EPPAPAPAAPAAPAAPEAEEPARP----EPPPAPKPKRRRRRASVPSWD 337
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 552-671 8.80e-07

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 51.69  E-value: 8.80e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 552 VTDQEATPVPPTGDSEATPVPPTGDSETAPV--PPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPvPPT 629
Cdd:NF040712  217 VEPAPAAEGAPATDSDPAEAGTPDDLASARRrrAGVEQPEDEPVGPGAAPAAEPDEATRDAGEPPAPGAAETPEAA-EPP 295

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1547055316 630 GDSGAPPVPPTGDSGAPPVPPtgdSGAPPVPPTGDSGAPPVP 671
Cdd:NF040712  296 APAPAAPAAPAAPEAEEPARP---EPPPAPKPKRRRRRASVP 334
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
536-716 2.01e-06

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 51.29  E-value: 2.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 536 TNFLRYWTLTYLALPTVTDQEATPVPPTGDSEA-----TPVPPTGDSETAPVPPTGDSGAP---PVPPTGDSGAPPVPPT 607
Cdd:COG3469    21 TLLGAAATAASVTLTAATATTVVSTTGSVVVAAsgsagSGTGTTAASSTAATSSTTSTTATataAAAAATSTSATLVATS 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 608 GDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDS 687
Cdd:COG3469   101 TASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATGGTTTTSTTTTTTSASTTPS 180

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1547055316 688 GAPPVPPTGDSG----APPVTPTGDSETAPVPP 716
Cdd:COG3469   181 ATTTATATTASGattpSATTTATTTGPPTPGLP 213
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 601-750 9.75e-06

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 48.61  E-value: 9.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 601 APPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPtgdsgAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPP 680
Cdd:NF040712  193 GRPLRPLATVPRLAREPADARPEEVEPAPAAEGAPATDS-----DPAEAGTPDDLASARRRRAGVEQPEDEPVGPGAAPA 267

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1547055316 681 VPPTGDSGAPPVPPtgdsgaPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEA--APVPPTDDSKEAQMPAV 750
Cdd:NF040712  268 AEPDEATRDAGEPP------APGAAETPEAAEPPAPAPAAPAAPAAPEAEEPArpEPPPAPKPKRRRRRASV 333
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 633-716 2.73e-05

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 47.30  E-value: 2.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 633 GAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPvtPTGDSETA 712
Cdd:NF041121   16 GRAAAPPSPEGPAPTAASQPATPPPPAAPPSPPGDPPEPPAPEPAPLPAPYPGSLAPPPPPPPGPAGAAP--GAALPVRV 93


                  ....
gi 1547055316 713 PVPP 716
Cdd:NF041121   94 PAPP 97
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 600-695 3.25e-05

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 47.30  E-value: 3.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 600 GAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPvpptGDAGPP 679
Cdd:NF041121   16 GRAAAPPSPEGPAPTAASQPATPPPPAAPPSPPGDPPEPPAPEPAPLPAPYPGSLAPPPPPPPGPAGAAP----GAALPV 91

                          90
                  ....*....|....*.
gi 1547055316 680 PVPptgdsgAPPVPPT 695
Cdd:NF041121   92 RVP------APPALPN 101
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 548-660 3.64e-05

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 46.68  E-value: 3.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 548 ALPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPvPPTGDSGAPPVP 627
Cdd:NF040712  226 APATDSDPAEAGTPDDLASARRRRAGVEQPEDEPVGPGAAPAAEPDEATRDAGEPPAPGAAETPEAA-EPPAPAPAAPAA 304

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1547055316 628 PTGDSGAPPVPPtgdSGAPPVPPTGDSGAPPVP 660
Cdd:NF040712  305 PAAPEAEEPARP---EPPPAPKPKRRRRRASVP 334
half-pint TIGR01645
poly-U binding splicing factor, half-pint family; The proteins represented by this model ...
 575-734 1.42e-04

poly-U binding splicing factor, half-pint family; The proteins represented by this model contain three RNA recognition motifs (rrm: pfam00076) and have been characterized as poly-pyrimidine tract binding proteins associated with RNA splicing factors. In the case of PUF60 (GP|6176532), in complex with p54, and in the presence of U2AF, facilitates association of U2 snRNP with pre-mRNA.


Pssm-ID: 130706 [Multi-domain]  Cd Length: 612  Bit Score: 45.06  E-value: 1.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 575 GDSETAPVP---PTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPtGDSGAPPVPPTG----DSGAPPVPPTGDSGAPP 647
Cdd:TIGR01645 279 GKCVTPPDAllqPATVSAIPAAAAVAAAAATAKIMAAEAVAGAAVL-GPRAQSPATPSSslptDIGNKAVVSSAKKEAEE 357

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 648 VPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGdSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPP 727
Cdd:TIGR01645 358 VPPLPQAAPAVVKPGPMEIPTPVPPPGLAIPSLVAPPG-LVAPTEINPSFLASPRKKMKREKLPVTFGALDDTLAWKEPS 436


                  ....*..
gi 1547055316 728 TGDSEAA 734
Cdd:TIGR01645 437 KEDQTSE 443
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 607-694 1.68e-04

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 44.99  E-value: 1.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 607 TGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPvpptGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGD 686
Cdd:NF041121   15 MGRAAAPPSPEGPAPTAASQPATPPPPAAPPSPPGDPPEPP----APEPAPLPAPYPGSLAPPPPPPPGPAGAAPGAALP 90


                  ....*...
gi 1547055316 687 SGAPPVPP 694
Cdd:NF041121   91 VRVPAPPA 98
DamX COG3266
Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell ...
 630-735 2.13e-04

Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442497 [Multi-domain]  Cd Length: 455  Bit Score: 44.46  E-value: 2.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 630 GDSGAPPVPPTGDSGAPPVPPTGDsGAPPVPPTG---DSGAPPVPPTGDAGPPPVPPTgdsgaPPVPPTgdsgAPPVTPT 706
Cdd:COG3266   262 SSASAPATTSLGEQQEVSLPPAVA-AQPAAAAAAqpsAVALPAAPAAAAAAAAPAEAA-----APQPTA----AKPVVTE 331

                          90       100
                  ....*....|....*....|....*....
gi 1547055316 707 GDSETAPVPPTGDSGAPPVPPTGDSEAAP 735
Cdd:COG3266   332 TAAPAAPAPEAAAAAAAPAAPAVAKKLAA 360
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 589-682 3.15e-04

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 43.84  E-value: 3.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 589 GAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPvpptGDSGAP 668
Cdd:NF041121   16 GRAAAPPSPEGPAPTAASQPATPPPPAAPPSPPGDPPEPPAPEPAPLPAPYPGSLAPPPPPPPGPAGAAP----GAALPV 91

                          90
                  ....*....|....
gi 1547055316 669 PVPptgdaGPPPVP 682
Cdd:NF041121   92 RVP-----APPALP 100
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 578-673 3.29e-04

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 43.84  E-value: 3.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 578 ETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPvpptGDSGAP 657
Cdd:NF041121   16 GRAAAPPSPEGPAPTAASQPATPPPPAAPPSPPGDPPEPPAPEPAPLPAPYPGSLAPPPPPPPGPAGAAP----GAALPV 91

                          90
                  ....*....|....*.
gi 1547055316 658 PVPptgdsgAPPVPPT 673
Cdd:NF041121   92 RVP------APPALPN 101
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 644-727 3.34e-04

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 43.84  E-value: 3.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 644 GAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPtGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAP 723
Cdd:NF041121   16 GRAAAPPSPEGPAPTAASQPATPPPPAAPPSPPGDPPEPP-APEPAPLPAPYPGSLAPPPPPPPGPAGAAPGAALPVRVP 94


                  ....
gi 1547055316 724 PVPP 727
Cdd:NF041121   95 APPA 98
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 640-738 3.71e-04

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 43.84  E-value: 3.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 640 TGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPvPPTGDSGAPPVPPtgdsgappvtptgdsETAPVPPTGD 719
Cdd:NF041121   15 MGRAAAPPSPEGPAPTAASQPATPPPPAAPPSPPGDPPEPP-APEPAPLPAPYPG---------------SLAPPPPPPP 78

                          90
                  ....*....|....*....
gi 1547055316 720 SGAPPVPPTGDSEAAPVPP 738
Cdd:NF041121   79 GPAGAAPGAALPVRVPAPP 97
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 563-662 5.61e-04

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 43.07  E-value: 5.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 563 TGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPvpptGDSGAPPVPPTGDSGAPPVPPTGDsgaPPVPPTGD 642
Cdd:NF041121   15 MGRAAAPPSPEGPAPTAASQPATPPPPAAPPSPPGDPPEPP----APEPAPLPAPYPGSLAPPPPPPPG---PAGAAPGA 87

                          90       100
                  ....*....|....*....|
gi 1547055316 643 SGAPPVPptgdsgAPPVPPT 662
Cdd:NF041121   88 ALPVRVP------APPALPN 101
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 622-705 1.50e-03

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 41.91  E-value: 1.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 622 GAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPtGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAP 701
Cdd:NF041121   16 GRAAAPPSPEGPAPTAASQPATPPPPAAPPSPPGDPPEPP-APEPAPLPAPYPGSLAPPPPPPPGPAGAAPGAALPVRVP 94


                  ....
gi 1547055316 702 PVTP 705
Cdd:NF041121   95 APPA 98
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 557-639 1.80e-03

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 41.53  E-value: 1.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 557 ATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPvPPTGDSGAPPVPPTGdsgaPPVPPTGDSGAPPVPPTGDSGAPP 636
Cdd:NF041121   20 APPSPEGPAPTAASQPATPPPPAAPPSPPGDPPEPP-APEPAPLPAPYPGSL----APPPPPPPGPAGAAPGAALPVRVP 94


                  ...
gi 1547055316 637 VPP 639
Cdd:NF041121   95 APP 97
KLF1_N cd21581
N-terminal domain of Kruppel-like Factor 1; Kruppel-like Factor 1 (KLF1, also known as ...
 561-707 2.12e-03

N-terminal domain of Kruppel-like Factor 1; Kruppel-like Factor 1 (KLF1, also known as Krueppel-like factor 1 or Erythroid Kruppel-like Factor/EKLF) was the first Kruppel-like factor discovered. It was found to be vitally important for embryonic erythropoiesis in promoting the switch from fetal hemoglobin (Hemoglobin F) to adult hemoglobin (Hemoglobin A) gene expression by binding to highly conserved CACCC domains. EKLF ablation in mouse embryos produces a lethal anemic phenotype, causing death by embryonic day 14, and natural mutations lead to beta+ thalassemia in humans. However, expression of embryonic hemoglobin and fetal hemoglobin genes is normal in EKLF-deficient mice, suggesting other factors may be involved. KLF1 functions as a transcriptional activator. It belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specifity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF1, which is related to the N-terminal domains of KLF2 and KLF4.


Pssm-ID: 409227 [Multi-domain]  Cd Length: 278  Bit Score: 40.80  E-value: 2.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 561 PPTGDSEATPVPPtGDSETAPVPPTGDSGAPPVPPTGDSG---APPVPPTGDSG-APPVPP-------TGDSGAPPVPPT 629
Cdd:cd21581    80 NPSLDNNTQALPQ-EEQPGAYYEPPKKDQPGTEGLQVGGPglmAELLSPEESTGwAPPEPHhgypdafVGPALFPAPANV 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 630 GDSGAPPVPPTGDSGAPPVPPTGDSG-------APPVPPTG-----DSGAPPVPPT-----------GDAGPPP----VP 682
Cdd:cd21581   159 DQFGFPQGGSVDRRGNLSKSGSWDFGsyypqqhPSVVAFPDsrfgpLSGPQALTPDpqhygyfqlfrHNAALFPdyahSP 238

                         170       180
                  ....*....|....*....|....*
gi 1547055316 683 PTGDSGAPPVPPTGDSGAPPVTPTG 707
Cdd:cd21581   239 GPGHLPLGQQPLLPDPPLPPGGAEG 263
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
 651-731 2.73e-03

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 40.65  E-value: 2.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 651 TGDSGAPPVPPTGdsgappvPPTGDAGPPPVPPTGDSGAPPvpptgdSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGD 730
Cdd:TIGR00601  81 TGKVAPPAATPTS-------APTPTPSPPASPASGMSAAPA------SAVEEKSPSEESATATAPESPSTSVPSSGSDAA 147


                  .
gi 1547055316 731 S 731
Cdd:TIGR00601 148 S 148
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 634-752 5.39e-03

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 39.75  E-value: 5.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 634 APPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPtgDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAP 713
Cdd:NF040712  193 GRPLRPLATVPRLAREPADARPEEVEPAPAAEGAPATDS--DPAEAGTPDDLASARRRRAGVEQPEDEPVGPGAAPAAEP 270

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1547055316 714 VPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMPAVIR 752
Cdd:NF040712  271 DEATRDAGEPPAPGAAETPEAAEPPAPAPAAPAAPAAPE 309
 
Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
26-542 0e+00

Carboxylesterase family;


Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 623.18  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  26 VYTEGGFVEGVNKKLGLlGDSVDIFKGIPFAAPTKAL---ENPQPHPGWQGTLKAKNFKKRCLQATITQDSTY----GDE 98
Cdd:pfam00135   5 VTTSLGRVRGKRLKVDG-GKPVYAFLGIPYAEPPVGElrfQPPEPPEPWTGVRDATKFGPRCPQNGDLTSPGSsgleGSE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  99 DCLYLNIWVPQGRKQVSRDLPVMIWIYGGAFLMGSGHganflnnyLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANL 178
Cdd:pfam00135  84 DCLYLNVYTPKELKENKNKLPVMVWIHGGGFMFGSGS--------LYDGSYLAAEGDVIVVTINYRLGPLGFLSTGDDEA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 179 PGNYGLRDQHMAIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQSGVALSPWVIQKNPLFWAK 258
Cdd:pfam00135 156 PGNYGLLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLSPLSKGLFHRAILMSGSALSPWAIQSNARQRAK 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 259 KVAEKVGCPVGDAARMAQCLKVTDPRALTLAYKVPlagLEYPMLHYVGFVPVIDGDFIPADPINLYA--NAADIDYIAGT 336
Cdd:pfam00135 236 ELAKLVGCPTSDSAELVECLRSKPAEELLDAQLKL---LVYGSVPFVPFGPVVDGDFLPEHPEELLKsgNFPKVPLLIGV 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 337 NNMDGHIFASIDMPAINKGNKKVTEEDFYKLVSEFTITKGL---RGAKTTFDVYTEsWAQDPSQENKKKTVVDFETDVLF 413
Cdd:pfam00135 313 TKDEGLLFAAYILDNVDILKALEEKLLRSLLIDLLYLLLVDlpeEISAALREEYLD-WGDRDDPETSRRALVELLTDYLF 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 414 LVPTEIALAQHRanAKSAKTYAYLFSHPSRMPVYPKWVGADHADDIQYVFGKPFATPTGYRPQDRTVSKAMIAYWTNFAK 493
Cdd:pfam00135 392 NCPVIRFADLHA--SRGTPVYMYSFDYRGSSLRYPKWVGVDHGDELPYVFGTPFVGALLFTEEDEKLSRKMMTYWTNFAK 469

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*....
gi 1547055316 494 TGDPNMGdsAVPTHWEPYTTENSGYLEITKKMgssSMKRSLRTNFLRYW 542
Cdd:pfam00135 470 TGNPNGP--EGLPKWPPYTDENGQYLSIDLEP---RVKQGLKAERCAFW 513
Esterase_lipase cd00312
Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on ...
 25-532 0e+00

Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These catalytic residues are responsible for the nucleophilic attack on the carbonyl carbon atom of the ester bond. In contrast with other alpha/beta hydrolase fold family members, p-nitrobenzyl esterase and acetylcholine esterase have a Glu instead of Asp at the active site carboxylate.


Pssm-ID: 238191 [Multi-domain]  Cd Length: 493  Bit Score: 573.51  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  25 AVYTEGGFVEGVNKklgllgDSVDIFKGIPFAAPT---KALENPQPHPGWQGTLKAKNFKKRCLQATITQDS-----TYG 96
Cdd:cd00312     1 LVVTPNGKVRGVDE------GGVYSFLGIPYAEPPvgdLRFKEPQPYEPWSDVLDATSYPPSCMQWDQLGGGlwnakLPG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  97 DEDCLYLNIWVPQGRKqVSRDLPVMIWIYGGAFLMGSGHganflnnyLYDGEEIATRG-NVIVVTFNYRVGPLGFLSTGD 175
Cdd:cd00312    75 SEDCLYLNVYTPKNTK-PGNSLPVMVWIHGGGFMFGSGS--------LYPGDGLAREGdNVIVVSINYRLGVLGFLSTGD 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 176 ANLPGNYGLRDQHMAIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQSGVALSPWVIQKNPLF 255
Cdd:cd00312   146 IELPGNYGLKDQRLALKWVQDNIAAFGGDPDSVTIFGESAGGASVSLLLLSPDSKGLFHRAISQSGSALSPWAIQENARG 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 256 WAKKVAEKVGCPVGDAARMAQCLKVTDPRALTLAYKVPlagLEYPMLHYVGFVPVIDGDFIPADPINLYA--NAADIDYI 333
Cdd:cd00312   226 RAKRLARLLGCNDTSSAELLDCLRSKSAEELLDATRKL---LLFSYSPFLPFGPVVDGDFIPDDPEELIKegKFAKVPLI 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 334 AGTNNMDGHIFASIDMPAINKgNKKVTEEDFYKLVSEFTITKGLRGAKTTFDVYTESWAQdpsQENKKKTVVDFETDVLF 413
Cdd:cd00312   303 IGVTKDEGGYFAAMLLNFDAK-LIIETNDRWLELLPYLLFYADDALADKVLEKYPGDVDD---SVESRKNLSDMLTDLLF 378

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 414 LVPTEIALAQHRANAKSaKTYAYLFSHPSRMPV--YPKWVGADHADDIQYVFGKPFATPTGYrPQDRTVSKAMIAYWTNF 491
Cdd:cd00312   379 KCPARYFLAQHRKAGGS-PVYAYVFDHRSSLSVgrWPPWLGTVHGDEIFFVFGNPLLKEGLR-EEEEKLSRTMMKYWANF 456

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|.
gi 1547055316 492 AKTGDPNMGDsaVPTHWEPYTTENSGYLEITkkMGSSSMKR 532
Cdd:cd00312   457 AKTGNPNTEG--NLVVWPAYTSESEKYLDIN--IEGTEIKQ 493
PnbA COG2272
Carboxylesterase type B [Lipid transport and metabolism];
26-521 2.41e-127

Carboxylesterase type B [Lipid transport and metabolism];


Pssm-ID: 441873  Cd Length: 500  Bit Score: 388.48  E-value: 2.41e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  26 VYTEGGFVEGVnkklglLGDSVDIFKGIPFAAPT------KAlenPQPHPGWQGTLKAKNFKKRCLQATITQD---STYG 96
Cdd:COG2272    15 VRTEAGRVRGV------VEGGVRVFLGIPYAAPPvgelrwRA---PQPVEPWTGVRDATEFGPACPQPPRPGDpggPAPG 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  97 DEDCLYLNIWVPqgRKQVSRDLPVMIWIYGGAFLMGSGHGAnflnnyLYDGEEIATRGnVIVVTFNYRVGPLGF-----L 171
Cdd:COG2272    86 SEDCLYLNVWTP--ALAAGAKLPVMVWIHGGGFVSGSGSEP------LYDGAALARRG-VVVVTINYRLGALGFlalpaL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 172 STGDANLPGNYGLRDQHMAIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQSGVAL---SPWV 248
Cdd:COG2272   157 SGESYGASGNYGLLDQIAALRWVRDNIAAFGGDPDNVTIFGESAGAASVAALLASPLAKGLFHRAIAQSGAGLsvlTLAE 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 249 IQKnplfWAKKVAEKVGCPVGDAArmaqCLKVTDPRALTLAYKVPLAGLEYPMlhyvGFVPVIDGDFIPADPINLYAN-- 326
Cdd:COG2272   237 AEA----VGAAFAAALGVAPATLA----ALRALPAEELLAAQAALAAEGPGGL----PFGPVVDGDVLPEDPLEAFAAgr 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 327 AADIDYIAGTNNMDGHIFASIDMPAinkgnKKVTEEDFyklvsEFTITKGLRG-AKTTFDVYTESWAQDpsqenkkkTVV 405
Cdd:COG2272   305 AADVPLLIGTNRDEGRLFAALLGDL-----GPLTAADY-----RAALRRRFGDdADEVLAAYPAASPAE--------ALA 366

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 406 DFETDVLFLVPTeIALAQHRAnAKSAKTYAYLFSHPSRMPVYPKWvGADHADDIQYVFGKPFA-TPTGYRPQDRTVSKAM 484
Cdd:COG2272   367 ALATDRVFRCPA-RRLAEAHA-AAGAPVYLYRFDWRSPPLRGFGL-GAFHGAELPFVFGNLDApALTGLTPADRALSDQM 443

                         490       500       510
                  ....*....|....*....|....*....|....*..
gi 1547055316 485 IAYWTNFAKTGDPNMGDsavPTHWEPYTTENSGYLEI 521
Cdd:COG2272   444 QAYWVNFARTGDPNGPG---LPEWPAYDPEDRAVMVF 477
Mucin-like pfam16058
Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated ...
 584-677 5.44e-22

Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated lipase, where is O-glycosylated. This region is composed of biased amino acid composition that is likely to be disordered. The region contains many repeats of an approximately 11 residue degenerate repeat.


Pssm-ID: 464997 [Multi-domain]  Cd Length: 94  Bit Score: 90.94  E-value: 5.44e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 584 PTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTG 663
Cdd:pfam16058   1 PSSSITEPPRDPSGSYGEPPRAPSSSYTEPQRDPSSSITEPPADPSSSYTEPPRDPSGSYTEPQRDPSSSSTEPQRDPSS 80

                          90
                  ....*....|....
gi 1547055316 664 DSGAPPVPPTGDAG 677
Cdd:pfam16058  81 SITEPPRDPSGSYT 94
Mucin-like pfam16058
Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated ...
 595-688 5.66e-22

Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated lipase, where is O-glycosylated. This region is composed of biased amino acid composition that is likely to be disordered. The region contains many repeats of an approximately 11 residue degenerate repeat.


Pssm-ID: 464997 [Multi-domain]  Cd Length: 94  Bit Score: 90.94  E-value: 5.66e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 595 PTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTG 674
Cdd:pfam16058   1 PSSSITEPPRDPSGSYGEPPRAPSSSYTEPQRDPSSSITEPPADPSSSYTEPPRDPSGSYTEPQRDPSSSSTEPQRDPSS 80

                          90
                  ....*....|....
gi 1547055316 675 DAGPPPVPPTGDSG 688
Cdd:pfam16058  81 SITEPPRDPSGSYT 94
Mucin-like pfam16058
Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated ...
 573-666 8.67e-22

Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated lipase, where is O-glycosylated. This region is composed of biased amino acid composition that is likely to be disordered. The region contains many repeats of an approximately 11 residue degenerate repeat.


Pssm-ID: 464997 [Multi-domain]  Cd Length: 94  Bit Score: 90.17  E-value: 8.67e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 573 PTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTG 652
Cdd:pfam16058   1 PSSSITEPPRDPSGSYGEPPRAPSSSYTEPQRDPSSSITEPPADPSSSYTEPPRDPSGSYTEPQRDPSSSSTEPQRDPSS 80

                          90
                  ....*....|....
gi 1547055316 653 DSGAPPVPPTGDSG 666
Cdd:pfam16058  81 SITEPPRDPSGSYT 94
Mucin-like pfam16058
Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated ...
 606-699 1.37e-21

Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated lipase, where is O-glycosylated. This region is composed of biased amino acid composition that is likely to be disordered. The region contains many repeats of an approximately 11 residue degenerate repeat.


Pssm-ID: 464997 [Multi-domain]  Cd Length: 94  Bit Score: 89.79  E-value: 1.37e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 606 PTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTG 685
Cdd:pfam16058   1 PSSSITEPPRDPSGSYGEPPRAPSSSYTEPQRDPSSSITEPPADPSSSYTEPPRDPSGSYTEPQRDPSSSSTEPQRDPSS 80

                          90
                  ....*....|....
gi 1547055316 686 DSGAPPVPPTGDSG 699
Cdd:pfam16058  81 SITEPPRDPSGSYT 94
Mucin-like pfam16058
Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated ...
 617-709 2.36e-21

Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated lipase, where is O-glycosylated. This region is composed of biased amino acid composition that is likely to be disordered. The region contains many repeats of an approximately 11 residue degenerate repeat.


Pssm-ID: 464997 [Multi-domain]  Cd Length: 94  Bit Score: 89.02  E-value: 2.36e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 617 PTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTG 696
Cdd:pfam16058   1 PSSSITEPPRDPSGSYGEPPRAPSSSYTEPQRDPSSSITEPPADPSSSYTEPPRDPSGSYTEPQRDPSSSSTEPQRDPSS 80

                          90
                  ....*....|...
gi 1547055316 697 DSGAPPVTPTGDS 709
Cdd:pfam16058  81 SITEPPRDPSGSY 93
Mucin-like pfam16058
Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated ...
 639-731 1.77e-20

Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated lipase, where is O-glycosylated. This region is composed of biased amino acid composition that is likely to be disordered. The region contains many repeats of an approximately 11 residue degenerate repeat.


Pssm-ID: 464997 [Multi-domain]  Cd Length: 94  Bit Score: 86.71  E-value: 1.77e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 639 PTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTG 718
Cdd:pfam16058   1 PSSSITEPPRDPSGSYGEPPRAPSSSYTEPQRDPSSSITEPPADPSSSYTEPPRDPSGSYTEPQRDPSSSSTEPQRDPSS 80

                          90
                  ....*....|...
gi 1547055316 719 DSGAPPVPPTGDS 731
Cdd:pfam16058  81 SITEPPRDPSGSY 93
Mucin-like pfam16058
Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated ...
 628-721 4.20e-20

Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated lipase, where is O-glycosylated. This region is composed of biased amino acid composition that is likely to be disordered. The region contains many repeats of an approximately 11 residue degenerate repeat.


Pssm-ID: 464997 [Multi-domain]  Cd Length: 94  Bit Score: 85.55  E-value: 4.20e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 628 PTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTG 707
Cdd:pfam16058   1 PSSSITEPPRDPSGSYGEPPRAPSSSYTEPQRDPSSSITEPPADPSSSYTEPPRDPSGSYTEPQRDPSSSSTEPQRDPSS 80

                          90
                  ....*....|....
gi 1547055316 708 DSETAPVPPTGDSG 721
Cdd:pfam16058  81 SITEPPRDPSGSYT 94
Mucin-like pfam16058
Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated ...
 562-655 9.99e-20

Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated lipase, where is O-glycosylated. This region is composed of biased amino acid composition that is likely to be disordered. The region contains many repeats of an approximately 11 residue degenerate repeat.


Pssm-ID: 464997 [Multi-domain]  Cd Length: 94  Bit Score: 84.39  E-value: 9.99e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 562 PTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTG 641
Cdd:pfam16058   1 PSSSITEPPRDPSGSYGEPPRAPSSSYTEPQRDPSSSITEPPADPSSSYTEPPRDPSGSYTEPQRDPSSSSTEPQRDPSS 80

                          90
                  ....*....|....
gi 1547055316 642 DSGAPPVPPTGDSG 655
Cdd:pfam16058  81 SITEPPRDPSGSYT 94
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 556-749 2.51e-19

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 93.13  E-value: 2.51e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 556 EATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAP 635
Cdd:PRK07764  599 GPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAP 678

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 636 PVPPTGDSGAPPVPPTGDSGAPPVPpTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPptgdSGAPPVTPTGDSETAPVP 715
Cdd:PRK07764  679 AAPPPAPAPAAPAAPAGAAPAQPAP-APAATPPAGQADDPAAQPPQAAQGASAPSPAA----DDPVPLPPEPDDPPDPAG 753

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1547055316 716 PTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMPA 749
Cdd:PRK07764  754 APAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAE 787
Mucin-like pfam16058
Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated ...
 650-742 3.42e-18

Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated lipase, where is O-glycosylated. This region is composed of biased amino acid composition that is likely to be disordered. The region contains many repeats of an approximately 11 residue degenerate repeat.


Pssm-ID: 464997 [Multi-domain]  Cd Length: 94  Bit Score: 80.16  E-value: 3.42e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 650 PTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTG 729
Cdd:pfam16058   1 PSSSITEPPRDPSGSYGEPPRAPSSSYTEPQRDPSSSITEPPADPSSSYTEPPRDPSGSYTEPQRDPSSSSTEPQRDPSS 80

                          90
                  ....*....|...
gi 1547055316 730 DSEAAPVPPTDDS 742
Cdd:pfam16058  81 SITEPPRDPSGSY 93
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 556-752 4.04e-18

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 89.27  E-value: 4.04e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 556 EATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAP 635
Cdd:PRK07764  610 EEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAA 689

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 636 PVPPTGDSGAPPVPpTGDSGAPPVPPTGDSGAPPVPPTGDAGPPP-----VPPTGDSGAPPVP-PTGDSGAPPVTPTGDS 709
Cdd:PRK07764  690 PAAPAGAAPAQPAP-APAATPPAGQADDPAAQPPQAAQGASAPSPaaddpVPLPPEPDDPPDPaGAPAQPPPPPAPAPAA 768

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1547055316 710 ETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMPAVIR 752
Cdd:PRK07764  769 APAAAPPPSPPSEEEEMAEDDAPSMDDEDRRDAEEVAMELLEE 811
PHA03247 PHA03247
large tegument protein UL36; Provisional
 550-745 2.57e-17

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 87.30  E-value: 2.57e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  550 PTVTDQEATP-VPPTGDSEATPVPPTGDS--ETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGD------ 620
Cdd:PHA03247  2580 PAVTSRARRPdAPPQSARPRAPVDDRGDPrgPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRddpapg 2659

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  621 ----------------SGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTgdsgAPPVPPTGDSGAPPVPPTGDAGPPPVPPT 684
Cdd:PHA03247  2660 rvsrprrarrlgraaqASSPPQRPRRRAARPTVGSLTSLADPPPPPP----TPEPAPHALVSATPLPPGPAAARQASPAL 2735

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1547055316  685 GDSGAPPVPPTGdsgapPVTPTGDSETA--PVPPTGDSGAPP-VPPTGDSEAAPVPPTDDSKEA 745
Cdd:PHA03247  2736 PAAPAPPAVPAG-----PATPGGPARPArpPTTAGPPAPAPPaAPAAGPPRRLTRPAVASLSES 2794
Mucin-like pfam16058
Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated ...
 553-644 6.58e-17

Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated lipase, where is O-glycosylated. This region is composed of biased amino acid composition that is likely to be disordered. The region contains many repeats of an approximately 11 residue degenerate repeat.


Pssm-ID: 464997 [Multi-domain]  Cd Length: 94  Bit Score: 76.31  E-value: 6.58e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 553 TDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDS 632
Cdd:pfam16058   3 SSITEPPRDPSGSYGEPPRAPSSSYTEPQRDPSSSITEPPADPSSSYTEPPRDPSGSYTEPQRDPSSSSTEPQRDPSSSI 82

                          90
                  ....*....|..
gi 1547055316 633 GAPPVPPTGDSG 644
Cdd:pfam16058  83 TEPPRDPSGSYT 94
PHA03247 PHA03247
large tegument protein UL36; Provisional
 548-750 8.08e-16

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 82.29  E-value: 8.08e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  548 ALPTVTDQEATPVPPTGDSEATPVPPTgdSETAPVPPTGDSGAPPVP-PTGDSGAP--PVPPTGDSGAPPVPPTgdsgAP 624
Cdd:PHA03247  2805 ADPPAAVLAPAAALPPAASPAGPLPPP--TSAQPTAPPPPPGPPPPSlPLGGSVAPggDVRRRPPSRSPAAKPA----AP 2878

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  625 PVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVT 704
Cdd:PHA03247  2879 ARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGA 2958

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 1547055316  705 PTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMPAV 750
Cdd:PHA03247  2959 VPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRV 3004
Mucin-like pfam16058
Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated ...
 661-746 1.40e-15

Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated lipase, where is O-glycosylated. This region is composed of biased amino acid composition that is likely to be disordered. The region contains many repeats of an approximately 11 residue degenerate repeat.


Pssm-ID: 464997 [Multi-domain]  Cd Length: 94  Bit Score: 72.45  E-value: 1.40e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 661 PTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTD 740
Cdd:pfam16058   1 PSSSITEPPRDPSGSYGEPPRAPSSSYTEPQRDPSSSITEPPADPSSSYTEPPRDPSGSYTEPQRDPSSSSTEPQRDPSS 80


                  ....*.
gi 1547055316 741 DSKEAQ 746
Cdd:pfam16058  81 SITEPP 86
PHA03247 PHA03247
large tegument protein UL36; Provisional
 465-746 1.52e-15

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 81.52  E-value: 1.52e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  465 KPFATPTGYRPQdrtVSKAMIAYWTNFAKTGDPNMGDSAVPTHWEPYTTENSGYLEITKKMGSSSMKRSLRTnflrywTL 544
Cdd:PHA03247  2675 QASSPPQRPRRR---AARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPA------VP 2745

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  545 TYLALPTVTDQEATPVPPTGDSEATP--VPPTGDSETAPVPPTGDSGA----------PPVPPTGDSGAPPVPPTGDSGA 612
Cdd:PHA03247  2746 AGPATPGGPARPARPPTTAGPPAPAPpaAPAAGPPRRLTRPAVASLSEsreslpspwdPADPPAAVLAPAAALPPAASPA 2825

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  613 PPVPPTgDSGAPPVPPTGDSGAPPVPPTGDSGAP--PVPPTGDSGAPPVPPTgdsgAPPVPPTGDAGPPPVPPTGDSGA- 689
Cdd:PHA03247  2826 GPLPPP-TSAQPTAPPPPPGPPPPSLPLGGSVAPggDVRRRPPSRSPAAKPA----APARPPVRRLARPAVSRSTESFAl 2900

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1547055316  690 ----PPVPPTGDSGAPPVTPtgdsETAPVPPTgDSGAPPVPPTGDSEAAPVPPTDDSKEAQ 746
Cdd:PHA03247  2901 ppdqPERPPQPQAPPPPQPQ----PQPPPPPQ-PQPPPPPPPRPQPPLAPTTDPAGAGEPS 2956
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 558-739 5.39e-15

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 78.66  E-value: 5.39e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 558 TPVPPTGDSEATPVP---PTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGA 634
Cdd:NF033839  283 TPKEPGNKKPSAPKPgmqPSPQPEKKEVKPEPETPKPEVKPQLEKPKPEVKPQPEKPKPEVKPQLETPKPEVKPQPEKPK 362

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 635 PPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTP---TGDSET 711
Cdd:NF033839  363 PEVKPQPEKPKPEVKPQPETPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPqpeKPKPEV 442

                         170       180
                  ....*....|....*....|....*...
gi 1547055316 712 APVPPTGDSGAPPVPPTGDSEAAPVPPT 739
Cdd:NF033839  443 KPQPEKPKPEVKPQPETPKPEVKPQPEK 470
PHA03247 PHA03247
large tegument protein UL36; Provisional
 547-749 8.25e-15

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 79.21  E-value: 8.25e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  547 LALPTVTDQEatpVPPTGDSEATPVPPTGDSETAP-VPPTGDSGAPPVPPTGDS--GAPPVPPTGDSGAPPVPPTGDSGA 623
Cdd:PHA03247  2558 AAPPAAPDRS---VPPPRPAPRPSEPAVTSRARRPdAPPQSARPRAPVDDRGDPrgPAPPSPLPPDTHAPDPPPPSPSPA 2634

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  624 PPVPPTGDSGAPPVPPTGDSGAPP------------VPPTGDSgAPPVPPTGDSGAPPVPPTGD-AGPPPVPPTgdsgaP 690
Cdd:PHA03247  2635 ANEPDPHPPPTVPPPERPRDDPAPgrvsrprrarrlGRAAQAS-SPPQRPRRRAARPTVGSLTSlADPPPPPPT-----P 2708

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1547055316  691 PVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGdseaaPVPPTDDSKEAQMPA 749
Cdd:PHA03247  2709 EPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAG-----PATPGGPARPARPPT 2762
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
105-246 9.00e-15

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 73.75  E-value: 9.00e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 105 IWVPQGRKqvsRDLPVMIWIYGGAFLMGSGHGANFLnnylydGEEIATRGNVIVVTFNYRVGPlgflstgDANLPGnyGL 184
Cdd:COG0657     3 VYRPAGAK---GPLPVVVYFHGGGWVSGSKDTHDPL------ARRLAARAGAAVVSVDYRLAP-------EHPFPA--AL 64

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1547055316 185 RDQHMAIAWVKRNIAAFGGDPNNITLFGESAGG--ASVSLQTLSPYNKGLIRRAISQSGV---ALSP 246
Cdd:COG0657    65 EDAYAALRWLRANAAELGIDPDRIAVAGDSAGGhlAAALALRARDRGGPRPAAQVLIYPVldlTASP 131
PHA03247 PHA03247
large tegument protein UL36; Provisional
 568-748 1.48e-14

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 78.06  E-value: 1.48e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  568 ATPVPPTGDSETAPVPPTGDSGAPPVPPTgdsgAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGdsgapP 647
Cdd:PHA03247  2678 SPPQRPRRRAARPTVGSLTSLADPPPPPP----TPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAG-----P 2748

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  648 VPPTGDSgAPPVPPTGDSGAPPVPPTGDAGPPP---VPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPP 724
Cdd:PHA03247  2749 ATPGGPA-RPARPPTTAGPPAPAPPAAPAAGPPrrlTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGP 2827

                          170       180
                   ....*....|....*....|....
gi 1547055316  725 VPPTGDSEAAPVPPTDDSKEAQMP 748
Cdd:PHA03247  2828 LPPPTSAQPTAPPPPPGPPPPSLP 2851
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 564-748 1.67e-14

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 77.12  E-value: 1.67e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 564 GDSEATPVPPTGDSETAPVP---PTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPT 640
Cdd:NF033839  278 GLTQDTPKEPGNKKPSAPKPgmqPSPQPEKKEVKPEPETPKPEVKPQLEKPKPEVKPQPEKPKPEVKPQLETPKPEVKPQ 357

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 641 GDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTP---TGDSETAPVPPT 717
Cdd:NF033839  358 PEKPKPEVKPQPEKPKPEVKPQPETPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPqpeKPKPEVKPQPEK 437

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1547055316 718 GDSGAPPVPPTGDSEAAPVPPTDDSKEAQMP 748
Cdd:NF033839  438 PKPEVKPQPEKPKPEVKPQPETPKPEVKPQP 468
Mucin-like pfam16058
Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated ...
 550-633 1.41e-13

Mucin-like; This region is found repeated at the C-terminus (C-tail) of bile salt-activated lipase, where is O-glycosylated. This region is composed of biased amino acid composition that is likely to be disordered. The region contains many repeats of an approximately 11 residue degenerate repeat.


Pssm-ID: 464997 [Multi-domain]  Cd Length: 94  Bit Score: 67.06  E-value: 1.41e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 550 PTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPT 629
Cdd:pfam16058  11 DPSGSYGEPPRAPSSSYTEPQRDPSSSITEPPADPSSSYTEPPRDPSGSYTEPQRDPSSSSTEPQRDPSSSITEPPRDPS 90


                  ....
gi 1547055316 630 GDSG 633
Cdd:pfam16058  91 GSYT 94
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 559-743 1.44e-13

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 74.82  E-value: 1.44e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  559 PVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVP-PTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVP--PTGDSGAP 635
Cdd:PHA03307   140 PVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPlSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRssPISASASS 219

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  636 PVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSG-APPVTPTGDSETAPV 714
Cdd:PHA03307   220 PAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGpASSSSSPRERSPSPS 299

                          170       180
                   ....*....|....*....|....*....
gi 1547055316  715 PPTGDSGAPPVPPTGDSEAAPVPPTDDSK 743
Cdd:PHA03307   300 PSSPGSGPAPSSPRASSSSSSSRESSSSS 328
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 568-749 3.86e-13

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 73.10  E-value: 3.86e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 568 ATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPP 647
Cdd:PRK07764  589 GPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDG 668

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 648 VPPTGDSGAPPVPPtgdsgaPPVPPTGDAGP-PPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVP 726
Cdd:PRK07764  669 WPAKAGGAAPAAPP------PAPAPAAPAAPaGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLP 742

                         170       180
                  ....*....|....*....|...
gi 1547055316 727 PTGDSEAAPVPPTDDSKEAQMPA 749
Cdd:PRK07764  743 PEPDDPPDPAGAPAQPPPPPAPA 765
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 555-742 5.36e-13

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 72.90  E-value: 5.36e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  555 QEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPV-PPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSG 633
Cdd:PHA03307   171 QAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRsSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWG 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  634 APPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSG-APPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETA 712
Cdd:PHA03307   251 PENECPLPRPAPITLPTRIWEASGWNGPSSRPGpASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTS 330

                          170       180       190
                   ....*....|....*....|....*....|
gi 1547055316  713 PVPPTGDSGAPPVPPTGDSEAAPVPPTDDS 742
Cdd:PHA03307   331 SSSESSRGAAVSPGPSPSRSPSPSRPPPPA 360
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 553-742 9.41e-13

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 72.13  E-value: 9.41e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  553 TDQEATPVPPTGDSEATPVPPtgDSETAPVPPTGDSGaPPVPPTGDSGAPPVP--PTGDSGAPPVPPTGDSGAPPVPPTG 630
Cdd:PHA03307   160 AAVASDAASSRQAALPLSSPE--ETARAPSSPPAEPP-PSTPPAAASPRPPRRssPISASASSPAPAPGRSAADDAGASS 236

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  631 DSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGP-PPVPPTGDSGAPPVPPTGDSGAPPVTPTGDS 709
Cdd:PHA03307   237 SDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPaSSSSSPRERSPSPSPSSPGSGPAPSSPRASS 316

                          170       180       190
                   ....*....|....*....|....*....|...
gi 1547055316  710 ETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDS 742
Cdd:PHA03307   317 SSSSSRESSSSSTSSSSESSRGAAVSPGPSPSR 349
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
544-750 1.21e-12

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 71.45  E-value: 1.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 544 LTYLAL-PTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPtgdSGAPPVPPTGDSGAPPVPPTGDSG 622
Cdd:PRK12323  358 LRMLAFrPGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAP---AAAAAARAVAAAPARRSPAPEALA 434

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 623 APPVPPTGDSGAPPVPPTGDSGAPpVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPP----VPPTGD-SGAPPVPPTGD 697
Cdd:PRK12323  435 AARQASARGPGGAPAPAPAPAAAP-AAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPadddPPPWEElPPEFASPAPAQ 513

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1547055316 698 SGAPPvtPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMPAV 750
Cdd:PRK12323  514 PDAAP--AGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPR 564
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 547-739 1.03e-11

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 68.66  E-value: 1.03e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  547 LALPTVTDQEATPVPPTGDSEA---TPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSG- 622
Cdd:PHA03307   172 AALPLSSPEETARAPSSPPAEPppsTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGp 251

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  623 --APPVPPTGDSGAPPVPptgDSGAPPVPPTGDSG-APPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSG 699
Cdd:PHA03307   252 enECPLPRPAPITLPTRI---WEASGWNGPSSRPGpASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSS 328

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1547055316  700 AppvTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPT 739
Cdd:PHA03307   329 T---SSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSP 365
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 556-738 2.08e-11

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 67.89  E-value: 2.08e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  556 EATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPvpPTGDSGAPPVPPTgDSGAPPVPPTGDSGAPPVPPTGDSGAP 635
Cdd:PHA03307    74 GPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPG--PSSPDPPPPTPPP-ASPPPSPAPDLSEMLRPVGSPGPPPAA 150

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  636 PVPPTGDSGAPPVPPTGDSGAPPVP-PTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVP--PTGDSGAPPVTPTGDSETA 712
Cdd:PHA03307   151 SPPAAGASPAAVASDAASSRQAALPlSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRssPISASASSPAPAPGRSAAD 230

                          170       180
                   ....*....|....*....|....*....
gi 1547055316  713 PVPPTGDSGAPPVPP---TGDSEAAPVPP 738
Cdd:PHA03307   231 DAGASSSDSSSSESSgcgWGPENECPLPR 259
PHA03247 PHA03247
large tegument protein UL36; Provisional
 548-715 4.30e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 66.89  E-value: 4.30e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  548 ALPTVTDQEATPVPPTGDSEATPVPPTGDSET-----APVPPTGD--SGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGD 620
Cdd:PHA03247  2817 ALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPslplgGSVAPGGDvrRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTE 2896

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  621 SGA-----PPVPPTGDSGAPPVP----PTGDSGAPPVPPTGDSGAPPVPPTGDSGAP------PVPPTGDAGP------- 678
Cdd:PHA03247  2897 SFAlppdqPERPPQPQAPPPPQPqpqpPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGepsgavPQPWLGALVPgrvavpr 2976

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1547055316  679 ---PPVPPTGDSGAPPVPPTGDSGAPPVTPTGDS-----ETAPVP 715
Cdd:PHA03247  2977 frvPQPAPSREAPASSTPPLTGHSLSRVSSWASSlalheETDPPP 3021
BD-FAE pfam20434
BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, ...
 103-232 5.04e-11

BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, previously known as bifunctional carbohydrate esterase (CE)), which is active on complex natural xylans and was identified as the basis of a monophyletic clade gathering all homologs identified in PULs (polysaccharide utilization loci) predicted to act on xylan. It adopts an alpha-beta-hydrolase fold with the catalytic triad Ser-Asp-His. This new family of proteins is a new candidate for biomass processing due to its capacity to remove ferulic acid and acetic acid from natural corn and birchwood xylan substrates.


Pssm-ID: 466583 [Multi-domain]  Cd Length: 215  Bit Score: 62.97  E-value: 5.04e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 103 LNIWVPQGRKqvsRDLPVMIWIYGGAFLMGSGHGANFLNNYLydGEEIATRGNViVVTFNYRvgplgflSTGDANLPGNy 182
Cdd:pfam20434   1 LDIYLPKNAK---GPYPVVIWIHGGGWNSGDKEADMGFMTNT--VKALLKAGYA-VASINYR-------LSTDAKFPAQ- 66

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1547055316 183 gLRDQHMAIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGL 232
Cdd:pfam20434  67 -IQDVKAAIRFLRANAAKYGIDTNKIALMGFSAGGHLALLAGLSNNNKEF 115
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 550-743 5.22e-11

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 65.95  E-value: 5.22e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 550 PTVTDQEATPVPP------TGDSEATPVPPTGDSETAPVPPTGDsgaPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGA 623
Cdd:NF033839  297 PGMQPSPQPEKKEvkpepeTPKPEVKPQLEKPKPEVKPQPEKPK---PEVKPQLETPKPEVKPQPEKPKPEVKPQPEKPK 373

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 624 PPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPV 703
Cdd:NF033839  374 PEVKPQPETPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEV 453

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1547055316 704 TPTGDSETAPVPPTGDSGAPPVPPTGDseaapVPPTDDSK 743
Cdd:NF033839  454 KPQPETPKPEVKPQPEKPKPEVKPQPE-----KPKPDNSK 488
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 550-738 5.41e-11

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 66.33  E-value: 5.41e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 550 PTVTDQEATPVPPtgdseatPVPPTGDSETAPVPPTgdSGAPPVPPtgdSGAPPVPPTGDSGAPPVPPTG--DSGAPPVP 627
Cdd:pfam03154 172 PVLQAQSGAASPP-------SPPPPGTTQAATAGPT--PSAPSVPP---QGSPATSQPPNQTQSTAAPHTliQQTPTLHP 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 628 PTGDSGAPPVPPTgdsgAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVP-PTGDSGAPPVPPTGDSGAPP---- 702
Cdd:pfam03154 240 QRLPSPHPPLQPM----TQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQhPVPPQPFPLTPQSSQSQVPPgpsp 315

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1547055316 703 VTPTGDSETAPVPPTGDSGAPPVPPtgdsEAAPVPP 738
Cdd:pfam03154 316 AAPGQSQQRIHTPPSQSQLQSQQPP----REQPLPP 347
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 565-738 6.18e-11

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 66.35  E-value: 6.18e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  565 DSEATPVPPTGDSETAPVPPTGDSG------APPVPPTGDSGAPPVPPTGDSGAPPvpptgdSGAPPVPPTGDSGAPPVP 638
Cdd:PHA03307    17 GGEFFPRPPATPGDAADDLLSGSQGqlvsdsAELAAVTVVAGAAACDRFEPPTGPP------PGPGTEAPANESRSTPTW 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  639 PTGDSGAPPVPPTGDSGappvPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPT---GDSGAPPVTPTGDSETAPVP 715
Cdd:PHA03307    91 SLSTLAPASPAREGSPT----PPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSpgpPPAASPPAAGASPAAVASDA 166

                          170       180
                   ....*....|....*....|...
gi 1547055316  716 PTGDSGAPPVPPTGDSEAAPVPP 738
Cdd:PHA03307   167 ASSRQAALPLSSPEETARAPSSP 189
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
556-739 6.59e-11

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 65.67  E-value: 6.59e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 556 EATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAP 635
Cdd:PRK12323  392 PAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRP 471

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 636 PVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVP 715
Cdd:PRK12323  472 VAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAP 551

                         170       180
                  ....*....|....*....|....
gi 1547055316 716 PTGDSGAPPVPPTGDSEAAPVPPT 739
Cdd:PRK12323  552 RAAAATEPVVAPRPPRASASGLPD 575
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 548-729 9.80e-11

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 65.58  E-value: 9.80e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  548 ALPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTgDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVP 627
Cdd:PHA03307    86 STPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPP-ASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVAS 164

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  628 PTGDSGAPPVP-PTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVP--PTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVT 704
Cdd:PHA03307   165 DAASSRQAALPlSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRssPISASASSPAPAPGRSAADDAGASSSDSSSSES 244

                          170       180
                   ....*....|....*....|....*...
gi 1547055316  705 P---TGDSETAPVPPTGDSGAPPVPPTG 729
Cdd:PHA03307   245 SgcgWGPENECPLPRPAPITLPTRIWEA 272
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 551-749 1.50e-10

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 64.81  E-value: 1.50e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  551 TVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTG-DSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPT 629
Cdd:PHA03307    24 PPATPGDAADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGpPPGPGTEAPANESRSTPTWSLSTLAPASPARE 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  630 GDSGAPPvpPTGDSGAPPVPPTgDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPV--PPTGDSGAPPVTPTG 707
Cdd:PHA03307   104 GSPTPPG--PSSPDPPPPTPPP-ASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVAsdAASSRQAALPLSSPE 180

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1547055316  708 DSETAPVPPtgdsgAPPVPPTGDSEAAPVPPTDDSKEAQMPA 749
Cdd:PHA03307   181 ETARAPSSP-----PAEPPPSTPPAAASPRPPRRSSPISASA 217
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 553-742 1.54e-10

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 64.81  E-value: 1.54e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  553 TDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGapPVPPTGDSGAPPvPPTGDSGAPPvPPTGDS 632
Cdd:PHA03307    58 GAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGS--PTPPGPSSPDPP-PPTPPPASPP-PSPAPD 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  633 GAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPvtptgDSETA 712
Cdd:PHA03307   134 LSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAAS-----PRPPR 208

                          170       180       190
                   ....*....|....*....|....*....|
gi 1547055316  713 PVPPTGDSGAPPVPPTGDSEAAPVPPTDDS 742
Cdd:PHA03307   209 RSSPISASASSPAPAPGRSAADDAGASSSD 238
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 547-704 1.63e-10

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 64.62  E-value: 1.63e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 547 LALPTVTDQEATpVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPptgdsGAPPVPPTGDSGAPPVPPtgdsGAPPV 626
Cdd:PRK07764  362 MLLPSASDDERG-LLARLERLERRLGVAGGAGAPAAAAPSAAAAAPAA-----APAPAAAAPAAAAAPAPA----AAPQP 431

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1547055316 627 PPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGdSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVT 704
Cdd:PRK07764  432 APAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAP-APAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADD 508
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 595-737 3.64e-10

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 63.19  E-value: 3.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 595 PTGDSGAPPVPPTgdsgAPPVPPTGDSGAP-PVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPt 673
Cdd:PRK14951  366 PAAAAEAAAPAEK----KTPARPEAAAPAAaPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAA- 440

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1547055316 674 gdaGPPPVPPtgdSGAPPVPPTGDSGAPP--VTPTGDSETAPVPPTGDSGAPPVPPT--GDSEAAPVP 737
Cdd:PRK14951  441 ---APAAVAL---APAPPAQAAPETVAIPvrVAPEPAVASAAPAPAAAPAAARLTPTeeGDVWHATVQ 502
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 604-741 4.54e-10

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 63.08  E-value: 4.54e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 604 VPPTGDSGAPPVPPTGDSGAPPVPptgdsGAPPVPPTGDSGAPPVPPtgdsGAPPVPPTGDSGAPPVPPTGDAGPPPVPP 683
Cdd:PRK07764  385 LGVAGGAGAPAAAAPSAAAAAPAA-----APAPAAAAPAAAAAPAPA----AAPQPAPAPAPAPAPPSPAGNAPAGGAPS 455

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1547055316 684 TGDSGAPPVPPTGdSGAPPVTPTGDSETAPVPPTGDSGAPPVPPtgdSEAAPVPPTDD 741
Cdd:PRK07764  456 PPPAAAPSAQPAP-APAAAPEPTAAPAPAPPAAPAPAAAPAAPA---APAAPAGADDA 509
PHA03247 PHA03247
large tegument protein UL36; Provisional
 567-752 4.62e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 63.42  E-value: 4.62e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  567 EATPVPPTGdsetAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPpVPP-------------TGDSGAPPvpptgdsg 633
Cdd:PHA03247  2486 ARFPFAAGA----APDPGGGGPPDPDAPPAPSRLAPAILPDEPVGEP-VHPrmltwirgleelaSDDAGDPP-------- 2552

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  634 aPPVPPtgdsgAPPvPPTGDSGAPPVPPTGDSGAPPVppTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAP 713
Cdd:PHA03247  2553 -PPLPP-----AAP-PAAPDRSVPPPRPAPRPSEPAV--TSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHA 2623

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1547055316  714 VPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMPAVIR 752
Cdd:PHA03247  2624 PDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVS 2662
PHA03169 PHA03169
hypothetical protein; Provisional
 573-739 6.09e-10

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 61.91  E-value: 6.09e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 573 PTGD-SETAPVPPTGDSGAPPVpptgdsGAPPVPPTGDSGAPPVPPTGDSGaPPVPPTGDSGAPPVPPTGDSGAPPVPPT 651
Cdd:PHA03169   92 PSGSgSESVGSPTPSPSGSAEE------LASGLSPENTSGSSPESPASHSP-PPSPPSHPGPHEPAPPESHNPSPNQQPS 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 652 GDSGappvPPTGDSGAPPVPPTG----DAGPPPVPPTGDSGAPPVPPtGDSGAPPVTPTGDSetAPVPPTGDSGAPPVPP 727
Cdd:PHA03169  165 SFLQ----PSHEDSPEEPEPPTSepepDSPGPPQSETPTSSPPPQSP-PDEPGEPQSPTPQQ--APSPNTQQAVEHEDEP 237

                         170
                  ....*....|..
gi 1547055316 728 TGDSEAAPVPPT 739
Cdd:PHA03169  238 TEPEREGPPFPG 249
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
561-746 7.74e-10

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 62.56  E-value: 7.74e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 561 PPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPpt 640
Cdd:PRK07003  367 APGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAAD-- 444

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 641 gdsGAPPVPPTGDSGAPPVPPTGDSGA-PPVPPTGDAGPPPV--PPTGDSGAPPVPPTGDSGAPPVTptgDSETAPVPPT 717
Cdd:PRK07003  445 ---GDAPVPAKANARASADSRCDERDAqPPADSGSASAPASDapPDAAFEPAPRAAAPSAATPAAVP---DARAPAAASR 518

                         170       180
                  ....*....|....*....|....*....
gi 1547055316 718 GDSGAPPVPPTgdSEAAPVPPTDDSKEAQ 746
Cdd:PRK07003  519 EDAPAAAAPPA--PEARPPTPAAAAPAAR 545
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 606-741 8.32e-10

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 62.04  E-value: 8.32e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 606 PTGDSGAPPVPPTgdsgAPPVPPTGDSGAP-PVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPT 684
Cdd:PRK14951  366 PAAAAEAAAPAEK----KTPARPEAAAPAAaPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAA 441

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1547055316 685 GDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTgdsgaPPVPPTGDSEAAPVPPTDD 741
Cdd:PRK14951  442 PAAVALAPAPPAQAAPETVAIPVRVAPEPAVAS-----AAPAPAAAPAAARLTPTEE 493
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 554-737 9.12e-10

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 62.50  E-value: 9.12e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  554 DQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTgDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSG 633
Cdd:PHA03307    81 ANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPP-ASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASP 159

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  634 APPVPPTGDSGAPPVP-PTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVP--PTGDSGAPPVPPTGDSGAPPVTPTGDSE 710
Cdd:PHA03307   160 AAVASDAASSRQAALPlSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRssPISASASSPAPAPGRSAADDAGASSSDS 239

                          170       180       190
                   ....*....|....*....|....*....|
gi 1547055316  711 TAPVPPTGDSG---APPVPPTGDSEAAPVP 737
Cdd:PHA03307   240 SSSESSGCGWGpenECPLPRPAPITLPTRI 269
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
578-745 1.11e-09

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 61.79  E-value: 1.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 578 ETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGD-SGAPPVPPTGDSGAP--PVPPTGDSGAPPVPPTGDS 654
Cdd:PRK07003  359 EPAVTGGGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAvTGAAGAALAPKAAAAaaATRAEAPPAAPAPPATADR 438

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 655 ------GAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPT 728
Cdd:PRK07003  439 gddaadGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASR 518

                         170
                  ....*....|....*..
gi 1547055316 729 GDSEAAPVPPTDDSKEA 745
Cdd:PRK07003  519 EDAPAAAAPPAPEARPP 535
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 593-723 1.28e-09

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 61.54  E-value: 1.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 593 VPPTGDSGAPPVPPTGDSGAPPVPptgdsGAPPVPPTGDSGAPPVPPtgdsGAPPVPPTGDSGAPPVPPTGDSGAPPVPP 672
Cdd:PRK07764  385 LGVAGGAGAPAAAAPSAAAAAPAA-----APAPAAAAPAAAAAPAPA----AAPQPAPAPAPAPAPPSPAGNAPAGGAPS 455

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1547055316 673 TGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAP 723
Cdd:PRK07764  456 PPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGA 506
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 550-678 1.34e-09

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 61.54  E-value: 1.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 550 PTVTDQEATPVPPTG-DSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPP 628
Cdd:PRK07764  387 VAGGAGAPAAAAPSAaAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQP 466

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1547055316 629 TGdSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPtgdSGAPPVPPTGDAGP 678
Cdd:PRK07764  467 AP-APAAAPEPTAAPAPAPPAAPAPAAAPAAPA---APAAPAGADDAATL 512
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 567-676 1.46e-09

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 61.36  E-value: 1.46e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 567 EATPVPPTGdseTAPVPPTGDSGAPPVPPTGDSGAPPVPPTgdSGAPPVPPTGDSgAPPVPPTGDSGAPPVPPTgdsgaP 646
Cdd:PRK14950  357 EALLVPVPA---PQPAKPTAAAPSPVRPTPAPSTRPKAAAA--ANIPPKEPVRET-ATPPPVPPRPVAPPVPHT-----P 425

                          90       100       110
                  ....*....|....*....|....*....|
gi 1547055316 647 PVPPTGDSGAPPVPPTGDSGAPPVPPTGDA 676
Cdd:PRK14950  426 ESAPKLTRAAIPVDEKPKYTPPAPPKEEEK 455
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 543-667 1.55e-09

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 61.36  E-value: 1.55e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 543 TLTYLALP---TVTDQEATPVPPtgdseATPVPPTGDSETAPVPPTGDSGAPPVPPTgdSGAPPVPPTGDSgAPPVPPTG 619
Cdd:PRK14950  343 TTSYGQLPlelAVIEALLVPVPA-----PQPAKPTAAAPSPVRPTPAPSTRPKAAAA--ANIPPKEPVRET-ATPPPVPP 414

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1547055316 620 DSGAPPVPPTgdsgaPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGA 667
Cdd:PRK14950  415 RPVAPPVPHT-----PESAPKLTRAAIPVDEKPKYTPPAPPKEEEKAL 457
PHA03247 PHA03247
large tegument protein UL36; Provisional
 565-745 1.62e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 61.88  E-value: 1.62e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  565 DSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGD-----SGAPPVPPTGDSGAPPVPPTGDSG------ 633
Cdd:PHA03247   253 AAPAPPPVVGEGADRAPETARGATGPPPPPEAAAPNGAAAPPDGVwgaalAGAPLALPAPPDPPPPAPAGDAEEeddedg 332

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  634 ----APPVP---------------PT------------GDSGAPPVPP------TGDSGAPPV--PPTGDSGAPPVPPTG 674
Cdd:PHA03247   333 amevVSPLPrprqhyplgfpkrrrPTwtppssledlsaGRHHPKRASLptrkrrSARHAATPFarGPGGDDQTRPAAPVP 412

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1547055316  675 DAGPPPVPPTGDSGAPPVPPTgdsgaPPVTPTGDSETAPVPPTgdSGAPPVPPTGDSEAAPVPPTDDSKEA 745
Cdd:PHA03247   413 ASVPTPAPTPVPASAPPPPAT-----PLPSAEPGSDDGPAPPP--ERQPPAPATEPAPDDPDDATRKALDA 476
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 582-723 1.73e-09

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 61.16  E-value: 1.73e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 582 VPPTGDSGAPPVPPTGDSGAPPVPptgdsGAPPVPPTGDSGAPPVPPtgdsGAPPVPPTGDSGAPPVPPTGDSGAPPVPP 661
Cdd:PRK07764  385 LGVAGGAGAPAAAAPSAAAAAPAA-----APAPAAAAPAAAAAPAPA----AAPQPAPAPAPAPAPPSPAGNAPAGGAPS 455

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1547055316 662 TGDSGAPPVPPTGDAGPPPVPPtgdsgAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAP 723
Cdd:PRK07764  456 PPPAAAPSAQPAPAPAAAPEPT-----AAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAATL 512
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 580-689 1.85e-09

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 60.98  E-value: 1.85e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 580 APVPPtgdsgAPPVPPTGDSGAPPVPPTGDSGAPPVPPTgdSGAPPVPPTGDSgAPPVPPTGDSGAPPVPPTgdsgaPPV 659
Cdd:PRK14950  361 VPVPA-----PQPAKPTAAAPSPVRPTPAPSTRPKAAAA--ANIPPKEPVRET-ATPPPVPPRPVAPPVPHT-----PES 427

                          90       100       110
                  ....*....|....*....|....*....|
gi 1547055316 660 PPTGDSGAPPVPPTGDAGPPPVPPTGDSGA 689
Cdd:PRK14950  428 APKLTRAAIPVDEKPKYTPPAPPKEEEKAL 457
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 548-749 2.42e-09

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 60.94  E-value: 2.42e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 548 ALPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTgdsgAPPVPPTGDSGAPPVP 627
Cdd:pfam03154 193 QAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPM----TQPPPPSQVSPQPLPQ 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 628 PTGDSGAPPVPPTGDSGAPPVP-PTGDSGAPPVPPTGDSGAPPVPPTGDAGP----PPVPPTGDSGAPPVPPTgDSGAPP 702
Cdd:pfam03154 269 PSLHGQMPPMPHSLQTGPSHMQhPVPPQPFPLTPQSSQSQVPPGPSPAAPGQsqqrIHTPPSQSQLQSQQPPR-EQPLPP 347

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1547055316 703 vTPTGDSETAPVPPTgdsgapPVPPTGDSEAAPVPPTDDSKEA-QMPA 749
Cdd:pfam03154 348 -APLSMPHIKPPPTT------PIPQLPNPQSHKHPPHLSGPSPfQMNS 388
PHA03169 PHA03169
hypothetical protein; Provisional
 561-723 3.07e-09

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 59.60  E-value: 3.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 561 PPTGDSEATPV-----PPTGDSETAPVPPTGDSGaPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGappvPPTGDSGAP 635
Cdd:PHA03169  103 PTPSPSGSAEElasglSPENTSGSSPESPASHSP-PPSPPSHPGPHEPAPPESHNPSPNQQPSSFLQ----PSHEDSPEE 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 636 PVPPTG----DSGAPPVPPTGDSGAPPVPPtGDSGAPPVPPTGDAGPPpvPPTGDSGAPPVPPTGDS--GAPPVTPTGDS 709
Cdd:PHA03169  178 PEPPTSepepDSPGPPQSETPTSSPPPQSP-PDEPGEPQSPTPQQAPS--PNTQQAVEHEDEPTEPEreGPPFPGHRSHS 254

                         170
                  ....*....|....*.
gi 1547055316 710 ET--APVPPTGDSGAP 723
Cdd:PHA03169  255 YTvvGWKPSTRPGGVP 270
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 550-749 3.62e-09

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 60.57  E-value: 3.62e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  550 PTVTDQEATPVPPTGDSEATPVPP---TGDSETAPVPPTGDSGAPPVPptgDSGAPPVPPTGDSG-APPVPPTGDSGAPP 625
Cdd:PHA03307   222 PAPGRSAADDAGASSSDSSSSESSgcgWGPENECPLPRPAPITLPTRI---WEASGWNGPSSRPGpASSSSSPRERSPSP 298

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  626 VPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTP 705
Cdd:PHA03307   299 SPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSP 378

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1547055316  706 TGDSETAPVPPTGDSGAPPV------PPTGDSEAAPVPPTDDSKEAQMPA 749
Cdd:PHA03307   379 AASAGRPTRRRARAAVAGRArrrdatGRFPAGRPRPSPLDAGAASGAFYA 428
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
557-734 3.64e-09

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 60.25  E-value: 3.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 557 ATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAP--PVPPTGDSGAPPVPPTGDSGAPPVPptgdsGA 634
Cdd:PRK07003  372 VPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAaaATRAEAPPAAPAPPATADRGDDAAD-----GD 446

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 635 PPVPPTGDSGAPPVPPTGDSGAPPV--PPTGDSGAPPVPPtgDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETA 712
Cdd:PRK07003  447 APVPAKANARASADSRCDERDAQPPadSGSASAPASDAPP--DAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAA 524

                         170       180
                  ....*....|....*....|..
gi 1547055316 713 PVPPTgdSGAPPVPPTGDSEAA 734
Cdd:PRK07003  525 AAPPA--PEARPPTPAAAAPAA 544
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 584-733 3.66e-09

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 60.11  E-value: 3.66e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 584 PTGDSGAPPVPPTgdsgAPPVPPTGDSGAP-PVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPT 662
Cdd:PRK14951  366 PAAAAEAAAPAEK----KTPARPEAAAPAAaPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAA 441

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1547055316 663 GDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTgdsgaPPVTPTGDSETAPVPPT--GDSGAPPVPPTGDSEA 733
Cdd:PRK14951  442 PAAVALAPAPPAQAAPETVAIPVRVAPEPAVAS-----AAPAPAAAPAAARLTPTeeGDVWHATVQQLAAAEA 509
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 550-689 3.96e-09

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 60.00  E-value: 3.96e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 550 PTVTDQEATPVPPTGDSEATPVPPTGDSETAPVpPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPptgdSGAPPVPPT 629
Cdd:PRK07764  670 PAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPA-PAPAATPPAGQADDPAAQPPQAAQGASAPSPAA----DDPVPLPPE 744

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 630 GDSGAPPVPPTGDSGAPPVPPTGDSGAPPvPPTGDSGAPPVPPTGDAGPPPVPPTGDSGA 689
Cdd:PRK07764  745 PDDPPDPAGAPAQPPPPPAPAPAAAPAAA-PPPSPPSEEEEMAEDDAPSMDDEDRRDAEE 803
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 561-738 4.76e-09

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 60.18  E-value: 4.76e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  561 PPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPtgDSGAPPVPP- 639
Cdd:PHA03307   211 SPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGP--SSRPGPASSs 288

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  640 --TGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTgdSGAPPVPPtGDSGAPPVTPTGDSETAPVPPT 717
Cdd:PHA03307   289 ssPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSES--SRGAAVSP-GPSPSRSPSPSRPPPPADPSSP 365

                          170       180
                   ....*....|....*....|.
gi 1547055316  718 GDSGAPPVPPTGDSEAAPVPP 738
Cdd:PHA03307   366 RKRPRPSRAPSSPAASAGRPT 386
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 562-715 4.78e-09

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 59.73  E-value: 4.78e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 562 PTGDSEATPVPPtgdSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPtg 641
Cdd:PRK14951  366 PAAAAEAAAPAE---KKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAA-- 440

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1547055316 642 dsGAPPVPPtgdsgaPPVPPTGDSGAPPVPPTGDAGPPPVPptgdSGAPPVPPTGDSGAPPVTPTGDSETAPVP 715
Cdd:PRK14951  441 --APAAVAL------APAPPAQAAPETVAIPVRVAPEPAVA----SAAPAPAAAPAAARLTPTEEGDVWHATVQ 502
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 555-738 5.01e-09

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 60.18  E-value: 5.01e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  555 QEATPVPPTGDSEATPVPPTGdsETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSG- 633
Cdd:PHA03307   252 ENECPLPRPAPITLPTRIWEA--SGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSt 329

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  634 -------APPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPT 706
Cdd:PHA03307   330 ssssessRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPA 409

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1547055316  707 GDSETAPVPPTGDSGAPPVP-----PTGDS--EAAPVPP 738
Cdd:PHA03307   410 GRPRPSPLDAGAASGAFYARyplltPSGEPwpGSPPPPP 448
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 601-752 7.40e-09

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 59.23  E-value: 7.40e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 601 APPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPP 680
Cdd:PRK07764  589 GPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDG 668

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1547055316 681 VPPtgdsGAPPVPPTGDSGAPPvtptgdsETAPVPPTGDSGAPPVPPtgdSEAAPVPPTDDSKEAQMPAVIR 752
Cdd:PRK07764  669 WPA----KAGGAAPAAPPPAPA-------PAAPAAPAGAAPAQPAPA---PAATPPAGQADDPAAQPPQAAQ 726
Abhydrolase_3 pfam07859
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 121-217 8.20e-09

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 400284 [Multi-domain]  Cd Length: 208  Bit Score: 56.45  E-value: 8.20e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 121 MIWIYGGAFLMGSghgANFLNNYLydgEEIATRGNVIVVTFNYRVGPlgflstgDANLPGnyGLRDQHMAIAWVKRNIAA 200
Cdd:pfam07859   1 LVYFHGGGFVLGS---ADTHDRLC---RRLAAEAGAVVVSVDYRLAP-------EHPFPA--AYDDAYAALRWLAEQAAE 65

                          90
                  ....*....|....*..
gi 1547055316 201 FGGDPNNITLFGESAGG 217
Cdd:pfam07859  66 LGADPSRIAVAGDSAGG 82
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
552-748 1.27e-08

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 58.32  E-value: 1.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 552 VTDQEATPVPPTGDS---EATPVPPTGDSET------APVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSG 622
Cdd:PRK07003  410 LAPKAAAAAAATRAEappAAPAPPATADRGDdaadgdAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAA 489

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 623 APPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSgAPPVPPtgdAGPPPVPPTG----------------- 685
Cdd:PRK07003  490 FEPAPRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAPEA-RPPTPA---AAAPAARAGGaaaaldvlrnagmrvss 565

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1547055316 686 DSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMP 748
Cdd:PRK07003  566 DRGARAAAAAKPAAAPAAAPKPAAPRVAVQVPTPRARAATGDAPPNGAARAEQAAESRGAPPP 628
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 625-734 1.28e-08

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 58.28  E-value: 1.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 625 PVPPtgdsgAPPVPPTGDSGAPPVPPTGDSGAPPVPPTgdSGAPPVPPTGDAGPPPVPPTgDSGAPPVPPTgdsgaPPVT 704
Cdd:PRK14950  362 PVPA-----PQPAKPTAAAPSPVRPTPAPSTRPKAAAA--ANIPPKEPVRETATPPPVPP-RPVAPPVPHT-----PESA 428

                          90       100       110
                  ....*....|....*....|....*....|
gi 1547055316 705 PTGDSETAPVPPTGDSGAPPVPPTGDSEAA 734
Cdd:PRK14950  429 PKLTRAAIPVDEKPKYTPPAPPKEEEKALI 458
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 547-744 1.30e-08

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 58.63  E-value: 1.30e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 547 LALPTVTDQEATPVPPTGDSEATPVPPtgdSETAPVPPTGDSGAPPVPPTGDSGAPPV--PPTgdsgAPPVPPTGDSGAP 624
Cdd:pfam03154 350 LSMPHIKPPPTTPIPQLPNPQSHKHPP---HLSGPSPFQMNSNLPPPPALKPLSSLSThhPPS----AHPPPLQLMPQSQ 422

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 625 PVPPtgdsgaPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVP--PTGDAGPPPVPPTgdSGAPPVPPTGDSGAPP 702
Cdd:pfam03154 423 QLPP------PPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPqhPFVPGGPPPITPP--SGPPTSTSSAMPGIQP 494

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1547055316 703 VTPTGDSETAPVPPTGDSGAPPV-----PP--TGDSEAAPVPPTDDSKE 744
Cdd:pfam03154 495 PSSASVSSSGPVPAAVSCPLPPVqikeeALdeAEEPESPPPPPRSPSPE 543
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 544-686 1.69e-08

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 57.80  E-value: 1.69e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 544 LTYLALPTVTDQEATPVPPTgdseATPVPPT-GDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTgdSG 622
Cdd:PRK14951  359 LRLLAFKPAAAAEAAAPAEK----KTPARPEaAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPA--AA 432

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1547055316 623 APPVPPTGDSGAPPVPPtgdsgAPPVPPTGDSGAPPV---PPTGDSGAPPVPPTGDAGPPPVP-PTGD 686
Cdd:PRK14951  433 APAAAPAAAPAAVALAP-----APPAQAAPETVAIPVrvaPEPAVASAAPAPAAAPAAARLTPtEEGD 495
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
548-736 1.76e-08

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 57.94  E-value: 1.76e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 548 ALPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTgdsGAPPVPPTGDSGAPPVPptgdsGAPPVP 627
Cdd:PRK07003  379 AVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPP---AAPAPPATADRGDDAAD-----GDAPVP 450

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 628 PTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTg 707
Cdd:PRK07003  451 AKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPA- 529

                         170       180
                  ....*....|....*....|....*....
gi 1547055316 708 dSETAPVPPTGDSgaPPVPPTGDSEAAPV 736
Cdd:PRK07003  530 -PEARPPTPAAAA--PAARAGGAAAALDV 555
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 550-742 1.89e-08

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 57.77  E-value: 1.89e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 550 PTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPP--------VPPTGDSGAPPVPPTGDSGAPPvPPTGDS 621
Cdd:COG5180   278 PGLPVLEAGSEPQSDAPEAETARPIDVKGVASAPPATRPVRPPggardpgtPRPGQPTERPAGVPEAASDAGQ-PPSAYP 356

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 622 GAPPVPPtGDSGAPPVPPTGDSGAPPVPPTGDSGAP----PVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGD 697
Cdd:COG5180   357 PAEEAVP-GKPLEQGAPRPGSSGGDGAPFQPPNGAPqpglGRRGAPGPPMGAGDLVQAALDGGGRETASLGGAAGGAGQG 435

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1547055316 698 SGAPPVTPTGDSETAPVPPTGDSGAPPVPptgdSEAAPVPPTDDS 742
Cdd:COG5180   436 PKADFVPGDAESVSGPAGLADQAGAAAST----AMADFVAPVTDA 476
PHA03247 PHA03247
large tegument protein UL36; Provisional
 558-730 2.29e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.03  E-value: 2.29e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  558 TPVPPTGDSEATPVPPTGDSETAPVPPTGD-----SGAPPVPPTGDSGAPPVPPTGDSG----------APPVP------ 616
Cdd:PHA03247   268 APETARGATGPPPPPEAAAPNGAAAPPDGVwgaalAGAPLALPAPPDPPPPAPAGDAEEeddedgamevVSPLPrprqhy 347

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  617 ---------PT------------GDSGAPPVPP------TGDSGAPPV--PPTGDSGAPPVPPTGDSGAPPVPPTGDSGA 667
Cdd:PHA03247   348 plgfpkrrrPTwtppssledlsaGRHHPKRASLptrkrrSARHAATPFarGPGGDDQTRPAAPVPASVPTPAPTPVPASA 427

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1547055316  668 PPVPptgdAGPPPVPPTGDSGAPPVPPTGDSGAP---PVTPTGDSETAPVPPTGDSGAPPVPPTGD 730
Cdd:PHA03247   428 PPPP----ATPLPSAEPGSDDGPAPPPERQPPAPatePAPDDPDDATRKALDALRERRPPEPPGAD 489
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
545-743 2.69e-08

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 57.07  E-value: 2.69e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 545 TYLALPTVTDQEATPVPPTgdseATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPP-----TGDSGAPPVPPTG 619
Cdd:COG3469    15 ASATAVTLLGAAATAASVT----LTAATATTVVSTTGSVVVAASGSAGSGTGTTAASSTAATssttsTTATATAAAAAAT 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 620 DSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSG 699
Cdd:COG3469    91 STSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATGGTTTTSTTT 170

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1547055316 700 APPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSK 743
Cdd:COG3469   171 TTTSASTTPSATTTATATTASGATTPSATTTATTTGPPTPGLPK 214
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 592-700 2.77e-08

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 57.13  E-value: 2.77e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 592 PVPPtgdsgAPPVPPTGDSGAPPVPPTGDSGAPPVPPTgdSGAPPVPPTGDSgAPPVPPTGDSGAPPVPPTgdsgaPPVP 671
Cdd:PRK14950  362 PVPA-----PQPAKPTAAAPSPVRPTPAPSTRPKAAAA--ANIPPKEPVRET-ATPPPVPPRPVAPPVPHT-----PESA 428

                          90       100
                  ....*....|....*....|....*....
gi 1547055316 672 PTGDAGPPPVPPTGDSGAPPVPPTGDSGA 700
Cdd:PRK14950  429 PKLTRAAIPVDEKPKYTPPAPPKEEEKAL 457
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 558-693 3.63e-08

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 55.93  E-value: 3.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 558 TPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPV 637
Cdd:NF040712  200 ATVPRLAREPADARPEEVEPAPAAEGAPATDSDPAEAGTPDDLASARRRRAGVEQPEDEPVGPGAAPAAEPDEATRDAGE 279

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1547055316 638 PPTGDSGAPPVP--PTGDSGAPPVPPTGDSGAPPVPPtgdAGPPPVPPTGDSGAPPVP 693
Cdd:NF040712  280 PPAPGAAETPEAaePPAPAPAAPAAPAAPEAEEPARP---EPPPAPKPKRRRRRASVP 334
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 632-750 3.92e-08

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 56.92  E-value: 3.92e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 632 SGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTgdSGAPPVPPTGDSGAPPVTPTGDSET 711
Cdd:PRK07764  383 RRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAP--APAPAPPSPAGNAPAGGAPSPPPAA 460

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1547055316 712 APVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMPAV 750
Cdd:PRK07764  461 APSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAA 499
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 603-709 4.23e-08

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 56.74  E-value: 4.23e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 603 PVPPtgdsgAPPVPPTGDSGAPPVPPTGDSGAPPVPPTgdSGAPPVPPTGDSgAPPVPPTGDSGAPPVPPtgdagPPPVP 682
Cdd:PRK14950  362 PVPA-----PQPAKPTAAAPSPVRPTPAPSTRPKAAAA--ANIPPKEPVRET-ATPPPVPPRPVAPPVPH-----TPESA 428

                          90       100
                  ....*....|....*....|....*..
gi 1547055316 683 PTGDSGAPPVPPTGDSGAPPVTPTGDS 709
Cdd:PRK14950  429 PKLTRAAIPVDEKPKYTPPAPPKEEEK 455
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 559-738 4.25e-08

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 57.08  E-value: 4.25e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 559 PVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVP-PTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPV 637
Cdd:pfam03154 149 PSPQDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAAtAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPH 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 638 P-----PTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGP-PPVPPTGDSGAPPVP-PTGDSGAPPVTPTGDSE 710
Cdd:pfam03154 229 TliqqtPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQmPPMPHSLQTGPSHMQhPVPPQPFPLTPQSSQSQ 308

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1547055316 711 TAPVPPTGDSG----APPVPPTGDSEAAPVPP 738
Cdd:pfam03154 309 VPPGPSPAAPGqsqqRIHTPPSQSQLQSQQPP 340
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 617-740 5.37e-08

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 56.23  E-value: 5.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 617 PTGDSGAPPvpptGDSGAPPvPPTGDSGAPPVPPT-GDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDsgAPPVPPT 695
Cdd:PRK14959  373 PSGGGASAP----SGSAAEG-PASGGAATIPTPGTqGPQGTAPAAGMTPSSAAPATPAPSAAPSPRVPWDD--APPAPPR 445

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1547055316 696 gdSGAPPVTPTGDSETAPVP--PTGDSGAPPVPPTGDSEAAPVPPTD 740
Cdd:PRK14959  446 --SGIPPRPAPRMPEASPVPgaPDSVASASDAPPTLGDPSDTAEHTP 490
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 584-707 5.37e-08

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 56.23  E-value: 5.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 584 PTGDSGAPPvpptGDSGAPPvPPTGDSGAPPVPPT-GDSGAPPVPP-TGDSGAPPVPPTGDSGAPPVPPtgdSGAPPVPP 661
Cdd:PRK14959  373 PSGGGASAP----SGSAAEG-PASGGAATIPTPGTqGPQGTAPAAGmTPSSAAPATPAPSAAPSPRVPW---DDAPPAPP 444

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1547055316 662 TGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPT-GDSGAP-PVTPTG 707
Cdd:PRK14959  445 RSGIPPRPAPRMPEASPVPGAPDSVASASDAPPTlGDPSDTaEHTPSG 492
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 540-731 7.75e-08

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 56.33  E-value: 7.75e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  540 RYWTLTYLALPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTG 619
Cdd:PHA03307   268 RIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSP 347

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  620 DSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPV------PPTGDAGPPPVPPTGDSGAPPVP 693
Cdd:PHA03307   348 SRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRArrrdatGRFPAGRPRPSPLDAGAASGAFY 427

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1547055316  694 PTGdsgaPPVTPTGDsetaPVPptgdsGAPPVPP-------TGDS 731
Cdd:PHA03307   428 ARY----PLLTPSGE----PWP-----GSPPPPPgrvryggLGDS 459
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
550-740 1.13e-07

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 55.24  E-value: 1.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 550 PTVTDQEATPVPPTGDSEATPVPPTGDSETAPvpPTGDSGAP----PVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPP 625
Cdd:PRK07003  448 PVPAKANARASADSRCDERDAQPPADSGSASA--PASDAPPDaafePAPRAAAPSAATPAAVPDARAPAAASREDAPAAA 525

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 626 VPPTGDSgAPPVPPtgdSGAPPVPPTGDSGAPPV------PPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVP-PTgdS 698
Cdd:PRK07003  526 APPAPEA-RPPTPA---AAAPAARAGGAAAALDVlrnagmRVSSDRGARAAAAAKPAAAPAAAPKPAAPRVAVQvPT--P 599

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1547055316 699 GAPPVTPTGD-SETAPVPPTGDSGAPPvPPTGDseaapVPPTD 740
Cdd:PRK07003  600 RARAATGDAPpNGAARAEQAAESRGAP-PPWED-----IPPDD 636
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 628-749 1.20e-07

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 55.11  E-value: 1.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 628 PTGDSGAPPVPPTgdsgAPPVPPTGDSGAP-PVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTgdSGAPPVTPT 706
Cdd:PRK14951  366 PAAAAEAAAPAEK----KTPARPEAAAPAAaPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPA--AAAPAAAPA 439

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1547055316 707 GDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMPA 749
Cdd:PRK14951  440 AAPAAVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAA 482
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 614-716 1.31e-07

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 54.82  E-value: 1.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 614 PVPPtgdsgAPPVPPTGDSGAPPVPPTGDSGAPPVPPTgdSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPtgdsgaPPVP 693
Cdd:PRK14950  362 PVPA-----PQPAKPTAAAPSPVRPTPAPSTRPKAAAA--ANIPPKEPVRETATPPPVPPRPVAPPVPHT------PESA 428

                          90       100
                  ....*....|....*....|...
gi 1547055316 694 PTGDSGAPPVtPTGDSETAPVPP 716
Cdd:PRK14950  429 PKLTRAAIPV-DEKPKYTPPAPP 450
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 566-715 1.33e-07

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 54.39  E-value: 1.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 566 SEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPV-PPTGDSGAPPVPPTGDSG 644
Cdd:NF040712  188 IDPDFGRPLRPLATVPRLAREPADARPEEVEPAPAAEGAPATDSDPAEAGTPDDLASARRRrAGVEQPEDEPVGPGAAPA 267

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1547055316 645 APPVPPTGDSGAPPVPPTGDSGAPPvPPTGDAGPPPVPPTGDSGAPPVPPtgdSGAPPVTPTGDSETAPVP 715
Cdd:NF040712  268 AEPDEATRDAGEPPAPGAAETPEAA-EPPAPAPAAPAAPAAPEAEEPARP---EPPPAPKPKRRRRRASVP 334
SAP130_C pfam16014
Histone deacetylase complex subunit SAP130 C-terminus;
557-738 1.39e-07

Histone deacetylase complex subunit SAP130 C-terminus;


Pssm-ID: 464973 [Multi-domain]  Cd Length: 371  Bit Score: 54.55  E-value: 1.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 557 ATPVppTGDSEATPVPpTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPvpptgdSGAPPVPPTGDSGAPP 636
Cdd:pfam16014  31 APPV--TVAVEALPGQ-NSEQQTASASPPSQHPAQAIPTILAPAAPPSQPSVVLSTLP------AAMAVTPPIPASMANV 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 637 VPPTGDSGAPPVPPTGDSGAPP-------VPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPP--VPPtgdsGAPP----- 702
Cdd:pfam16014 102 VAPPTQPAASSTAACAVSSVLPeikikqeAEPMDTSQSVPPLTPTSISPALTSLANNLSVPAgdLLP----GASPrkkpr 177

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1547055316 703 ----VTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPP 738
Cdd:pfam16014 178 kqqhVISTEEGEMMETNSTDEEKSAPKPLTSRAEKRKSPP 217
dnaA PRK14086
chromosomal replication initiator protein DnaA;
557-743 1.46e-07

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 54.83  E-value: 1.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 557 ATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGA---PPVPPTGDSGAP-PVPPTGDS 632
Cdd:PRK14086   85 AITVDPSAGEPAPPPPHARRTSEPELPRPGRRPYEGYGGPRADDRPPGLPRQDQLPtarPAYPAYQQRPEPgAWPRAADD 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 633 GAPPVPPTG-DSGAPPVPPTGDSGAPPV--PPTGDSGAPPVPPTGD---AGPPPVPPTGDSGAPPVPPTGdSGAPPVTPT 706
Cdd:PRK14086  165 YGWQQQRLGfPPRAPYASPASYAPEQERdrEPYDAGRPEYDQRRRDydhPRPDWDRPRRDRTDRPEPPPG-AGHVHRGGP 243

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1547055316 707 GDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSK 743
Cdd:PRK14086  244 GPPERDDAPVVPIRPSAPGPLAAQPAPAPGPGEPTAR 280
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 548-677 1.68e-07

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 54.99  E-value: 1.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 548 ALPTVTDQEATPVPPTGDSEATPVPpTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPptgdSGAPPVPPTGDSGAPPVP 627
Cdd:PRK07764  679 AAPPPAPAPAAPAAPAGAAPAQPAP-APAATPPAGQADDPAAQPPQAAQGASAPSPAA----DDPVPLPPEPDDPPDPAG 753

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1547055316 628 PTGDSGAPPVPPTGDSGAPPvPPTGDSGAPPVPPTGDSGAPPVPPTGDAG 677
Cdd:PRK07764  754 APAQPPPPPAPAPAAAPAAA-PPPSPPSEEEEMAEDDAPSMDDEDRRDAE 802
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 636-751 2.72e-07

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 54.05  E-value: 2.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 636 PVPPtgdsgAPPVPPTGDSGAPPVPPTGDSGAPPVPPTgdAGPPPVPPTGDSgAPPVPPTGDSGAPPVTPTgdsetAPVP 715
Cdd:PRK14950  362 PVPA-----PQPAKPTAAAPSPVRPTPAPSTRPKAAAA--ANIPPKEPVRET-ATPPPVPPRPVAPPVPHT-----PESA 428

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1547055316 716 PTGDSGAPPVPPTGDSEaAPVPPTDDSKEAQMPAVI 751
Cdd:PRK14950  429 PKLTRAAIPVDEKPKYT-PPAPPKEEEKALIADGDV 463
dnaA PRK14086
chromosomal replication initiator protein DnaA;
551-735 3.26e-07

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 53.68  E-value: 3.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 551 TVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGapPVPPTGDSGAP---------PVPPTGDS 621
Cdd:PRK14086   87 TVDPSAGEPAPPPPHARRTSEPELPRPGRRPYEGYGGPRADDRPPGLPRQ--DQLPTARPAYPayqqrpepgAWPRAADD 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 622 GAPPVPPTG-DSGAPPVPPTGDS-GAPPVPPTGDSGAPPVPPTGDSGAPPVP----PTGDAGPPPVPPTGdSGAPPVPPT 695
Cdd:PRK14086  165 YGWQQQRLGfPPRAPYASPASYApEQERDREPYDAGRPEYDQRRRDYDHPRPdwdrPRRDRTDRPEPPPG-AGHVHRGGP 243

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1547055316 696 GDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAP 735
Cdd:PRK14086  244 GPPERDDAPVVPIRPSAPGPLAAQPAPAPGPGEPTARLNP 283
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 590-741 3.48e-07

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 52.85  E-value: 3.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 590 APPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPtgDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPP 669
Cdd:NF040712  193 GRPLRPLATVPRLAREPADARPEEVEPAPAAEGAPATDS--DPAEAGTPDDLASARRRRAGVEQPEDEPVGPGAAPAAEP 270

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1547055316 670 VPPTGDAGPPPVPPTGDSGAPPvPPTGDSGAPPVTPTGDSETAPVPPtgdSGAPPVPPTGDSEAAPVPPTDD 741
Cdd:NF040712  271 DEATRDAGEPPAPGAAETPEAA-EPPAPAPAAPAAPAAPEAEEPARP---EPPPAPKPKRRRRRASVPSWDD 338
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 556-708 3.97e-07

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 52.85  E-value: 3.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 556 EATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPV-PPTGDSGAPPVPPTGDSGA 634
Cdd:NF040712  189 DPDFGRPLRPLATVPRLAREPADARPEEVEPAPAAEGAPATDSDPAEAGTPDDLASARRRrAGVEQPEDEPVGPGAAPAA 268

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1547055316 635 PPVPPTGDSGAPPVPPTGDSGAPPvPPTGDSGAPPVPPTGDAGPPPVPPtgdsGAPPVPPTGDSGAPPVTPTGD 708
Cdd:NF040712  269 EPDEATRDAGEPPAPGAAETPEAA-EPPAPAPAAPAAPAAPEAEEPARP----EPPPAPKPKRRRRRASVPSWD 337
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 617-750 4.09e-07

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 53.33  E-value: 4.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 617 PTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPtgdsgAPPVPPtgdAGPPPVPPTGDSGAPP--VPP 694
Cdd:PRK07994  361 PAAPLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPAS-----APQQAP---AVPLPETTSQLLAARQqlQRA 432

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1547055316 695 TGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMPAV 750
Cdd:PRK07994  433 QGATKAKKSEPAAASRARPVNSALERLASVRPAPSALEKAPAKKEAYRWKATNPVE 488
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
548-705 4.54e-07

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 53.34  E-value: 4.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 548 ALPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVP-------------PTGDSGAPPVPPTGDSGA--PPVPPTGDSGA 612
Cdd:PRK12323  395 AAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPealaaarqasargPGGAPAPAPAPAAAPAAAarPAAAGPRPVAA 474

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 613 PPVPPTGDSGAPPVPPTGDSGAPP---VPPTGDSGAP----PVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTG 685
Cdd:PRK12323  475 AAAAAPARAAPAAAPAPADDDPPPweeLPPEFASPAPaqpdAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAA 554

                         170       180
                  ....*....|....*....|....
gi 1547055316 686 DSGAPPVPPT----GDSGAPPVTP 705
Cdd:PRK12323  555 AATEPVVAPRppraSASGLPDMFD 578
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
555-701 4.78e-07

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 53.34  E-value: 4.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 555 QEATPVPPTGDSEATPVPPTgdsetAPVPPTGDSGAPPVPPTGDSGAPPV---PPTGDSGAPPVPPTGDSGAPPVPPTGD 631
Cdd:PRK12323  437 RQASARGPGGAPAPAPAPAA-----APAAAARPAAAGPRPVAAAAAAAPAraaPAAAPAPADDDPPPWEELPPEFASPAP 511

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1547055316 632 SGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPT-GDSGAPPVPPTGDSGAP 701
Cdd:PRK12323  512 AQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRpPRASASGLPDMFDGDWP 582
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 595-717 4.97e-07

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 53.15  E-value: 4.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 595 PTGDSGAPPvpptGDSGAPPvPPTGDSGAPPVPPT-GDSGAPPVPP-TGDSGAPPVPPTGDSGAPPVPPtgdSGAPPVPP 672
Cdd:PRK14959  373 PSGGGASAP----SGSAAEG-PASGGAATIPTPGTqGPQGTAPAAGmTPSSAAPATPAPSAAPSPRVPW---DDAPPAPP 444

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1547055316 673 TGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPT 717
Cdd:PRK14959  445 RSGIPPRPAPRMPEASPVPGAPDSVASASDAPPTLGDPSDTAEHT 489
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
118-243 5.49e-07

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 51.17  E-value: 5.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 118 LPVMIWIYGGaflmgsghGANFLNNYLYDGEEIATRGnVIVVTFNYRvgplGFlsTGDANLPGNYGLRDQHMAIAWVkrn 197
Cdd:COG1506    23 YPVVVYVHGG--------PGSRDDSFLPLAQALASRG-YAVLAPDYR----GY--GESAGDWGGDEVDDVLAAIDYL--- 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1547055316 198 IAAFGGDPNNITLFGESAGGASVSLqtLSPYNKGLIRRAISQSGVA 243
Cdd:COG1506    85 AARPYVDPDRIGIYGHSYGGYMALL--AAARHPDRFKAAVALAGVS 128
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 552-671 8.80e-07

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 51.69  E-value: 8.80e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 552 VTDQEATPVPPTGDSEATPVPPTGDSETAPV--PPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPvPPT 629
Cdd:NF040712  217 VEPAPAAEGAPATDSDPAEAGTPDDLASARRrrAGVEQPEDEPVGPGAAPAAEPDEATRDAGEPPAPGAAETPEAA-EPP 295

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1547055316 630 GDSGAPPVPPTGDSGAPPVPPtgdSGAPPVPPTGDSGAPPVP 671
Cdd:NF040712  296 APAPAAPAAPAAPEAEEPARP---EPPPAPKPKRRRRRASVP 334
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 606-728 9.47e-07

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 52.37  E-value: 9.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 606 PTGDSGAPPvpptGDSGAPPvPPTGDSGAPPVPPT-GDSGAPPVPP-TGDSGAPPVPPTGDSGAPPVpPTGDAgpPPVPP 683
Cdd:PRK14959  373 PSGGGASAP----SGSAAEG-PASGGAATIPTPGTqGPQGTAPAAGmTPSSAAPATPAPSAAPSPRV-PWDDA--PPAPP 444

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1547055316 684 TgdSGAPPVPPTGDSGAPPVT--PTGDSETAPVPPTGDSGAPPVPPT 728
Cdd:PRK14959  445 R--SGIPPRPAPRMPEASPVPgaPDSVASASDAPPTLGDPSDTAEHT 489
PHA03378 PHA03378
EBNA-3B; Provisional
 550-705 1.01e-06

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 52.38  E-value: 1.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 550 PTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPP--VPPTgdsgaPPVPPTGDSGAPPvPPTGDSGAPPVP 627
Cdd:PHA03378  664 PTWTQIGHIPYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPpaAPPG-----RAQRPAAATGRAR-PPAAAPGRARPP 737

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 628 PTGDSGAPPVPPTGDSGAPPV-------PPTGDSGAP-PVPPtgdSGAPPVP-PTGDAGPPPVPPtgdsgaPPVPPTGDS 698
Cdd:PHA03378  738 AAAPGRARPPAAAPGRARPPAaapgrarPPAAAPGAPtPQPP---PQAPPAPqQRPRGAPTPQPP------PQAGPTSMQ 808


                  ....*..
gi 1547055316 699 GAPPVTP 705
Cdd:PHA03378  809 LMPRAAP 815
PHA03247 PHA03247
large tegument protein UL36; Provisional
 583-748 1.17e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.63  E-value: 1.17e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  583 PPTGDSGAPPVPPTGDSGA--PPVPPTGDSGAPPVPPTGDSGAPPVPPTGD-----SGAPPVPPtgdsgAPPVPPTGDSG 655
Cdd:PHA03247   247 PLRGDIAAPAPPPVVGEGAdrAPETARGATGPPPPPEAAAPNGAAAPPDGVwgaalAGAPLALP-----APPDPPPPAPA 321

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  656 APPVPPTGDSGA----PPVP------PTGDAG---PPPVPPT-------GDSGAPPVPP------TGDSGAPPVT--PTG 707
Cdd:PHA03247   322 GDAEEEDDEDGAmevvSPLPrprqhyPLGFPKrrrPTWTPPSsledlsaGRHHPKRASLptrkrrSARHAATPFArgPGG 401

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1547055316  708 DSETAPVPPTgdSGAPPVP-PTGDSEAAPVPPTDDSKEAQMP 748
Cdd:PHA03247   402 DDQTRPAAPV--PASVPTPaPTPVPASAPPPPATPLPSAEPG 441
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 550-749 1.24e-06

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 52.39  E-value: 1.24e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  550 PTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPptgdSGAPPVPPTGDSGA----------PPVPPTGDSGAPPVPPTG 619
Cdd:PRK10263   344 PPVASVDVPPAQPTVAWQPVPGPQTGEPVIAPAP----EGYPQQSQYAQPAVqyneplqqpvQPQQPYYAPAAEQPAQQP 419

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  620 DSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVP---PTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTG 696
Cdd:PRK10263   420 YYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQStyqTEQTYQQPAAQEPLYQQPQPVEQQPVVEPEPVVEET 499

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1547055316  697 DSGAPPV-----------------------TPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMPA 749
Cdd:PRK10263   500 KPARPPLyyfeeveekrarereqlaawyqpIPEPVKEPEPIKSSLKAPSVAAVPPVEAAAAVSPLASGVKKATLAT 575
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 561-678 1.28e-06

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 51.99  E-value: 1.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 561 PPTGdsEATPVPPTGDSETAPVPPT-GDSGAPPVPP-TGDSGAPPVPPTGDSGAPPVPPtgdSGAPPVPPTgdSGAPPVP 638
Cdd:PRK14959  380 APSG--SAAEGPASGGAATIPTPGTqGPQGTAPAAGmTPSSAAPATPAPSAAPSPRVPW---DDAPPAPPR--SGIPPRP 452

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1547055316 639 PTGDSGAPPVP--PTGDSGAPPVPPTGDSGAPPVPPTgDAGP 678
Cdd:PRK14959  453 APRMPEASPVPgaPDSVASASDAPPTLGDPSDTAEHT-PSGP 493
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 573-728 1.38e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 51.79  E-value: 1.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 573 PTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVP-PTGDSGAPPVPPtgdSGAPPVPPTGDSGAPP--VPPTGDSGAPPVP 649
Cdd:PRK07994  366 PEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAvPPPPASAPQQAP---AVPLPETTSQLLAARQqlQRAQGATKAKKSE 442

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1547055316 650 PTGDSGAPPVPPTGDSGApPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPT 728
Cdd:PRK07994  443 PAAASRARPVNSALERLA-SVRPAPSALEKAPAKKEAYRWKATNPVEVKKEPVATPKALKKALEHEKTPELAAKLAAEA 520
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 558-725 1.45e-06

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 52.01  E-value: 1.45e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  558 TPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPptgdSGAPPVPPTGDSGAPPVPPTgDSGAPPVPPTGDSGAPPV 637
Cdd:PRK10263   341 TQTPPVASVDVPPAQPTVAWQPVPGPQTGEPVIAPAP----EGYPQQSQYAQPAVQYNEPL-QQPVQPQQPYYAPAAEQP 415

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  638 PPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVP---PTGDSGAPPVPPTGDSGAPPVTPTGDSETAPV 714
Cdd:PRK10263   416 AQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQStyqTEQTYQQPAAQEPLYQQPQPVEQQPVVEPEPV 495

                          170
                   ....*....|.
gi 1547055316  715 PPTGDSGAPPV 725
Cdd:PRK10263   496 VEETKPARPPL 506
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 572-684 1.47e-06

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 51.60  E-value: 1.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 572 PPTGDSetAPVPPTGDSGAPPVPPT-GDSGAPPVPP-TGDSGAPPVPPTGDSGAPPVPPtgdSGAPPVPPTgdSGAPPVP 649
Cdd:PRK14959  380 APSGSA--AEGPASGGAATIPTPGTqGPQGTAPAAGmTPSSAAPATPAPSAAPSPRVPW---DDAPPAPPR--SGIPPRP 452

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1547055316 650 PTGDSGAPPVP--PTGDSGAPPVPPTGDAGPPPVPPT 684
Cdd:PRK14959  453 APRMPEASPVPgaPDSVASASDAPPTLGDPSDTAEHT 489
PLN02217 PLN02217
probable pectinesterase/pectinesterase inhibitor
 611-713 1.50e-06

probable pectinesterase/pectinesterase inhibitor


Pssm-ID: 215130 [Multi-domain]  Cd Length: 670  Bit Score: 51.63  E-value: 1.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 611 GAPPVPP--TGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDsgappvPPTGDSGAPPVPPTGDAGPPPVPPTGDSG 688
Cdd:PLN02217  554 GVPYIPGlfAGNPGSTNSTPTGSAASSNTTFSSDSPSTVVAPSTS------PPAGHLGSPPATPSKIVSPSTSPPASHLG 627

                          90       100
                  ....*....|....*....|....*
gi 1547055316 689 APPVPPTgdSGAPPVTPTGDSETAP 713
Cdd:PLN02217  628 SPSTTPS--SPESSIKVASTETASP 650
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 584-738 1.53e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 51.79  E-value: 1.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 584 PTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPtgdsgAPPVPPtgdSGAPPVPPTGDSGAPP--VPP 661
Cdd:PRK07994  361 PAAPLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPAS-----APQQAP---AVPLPETTSQLLAARQqlQRA 432

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1547055316 662 TGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDS--ETAPVPPTGDSGAPPVPPTGDSEAAPVPP 738
Cdd:PRK07994  433 QGATKAKKSEPAAASRARPVNSALERLASVRPAPSALEKAPAKKEAYRwkATNPVEVKKEPVATPKALKKALEHEKTPE 511
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 595-746 1.67e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 51.40  E-value: 1.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 595 PTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPtgdsgAPPVPPtgdSGAPPVPPTGDSGAPP--VPP 672
Cdd:PRK07994  361 PAAPLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPAS-----APQQAP---AVPLPETTSQLLAARQqlQRA 432

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1547055316 673 TGDAGPPPVPPTGDSGAPPVPptgdSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQ 746
Cdd:PRK07994  433 QGATKAKKSEPAAASRARPVN----SALERLASVRPAPSALEKAPAKKEAYRWKATNPVEVKKEPVATPKALKK 502
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 549-737 1.71e-06

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 51.47  E-value: 1.71e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 549 LPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDsgAPPVP------------------------PTGDSGAPPV 604
Cdd:PLN03209  320 LAKIPSQRVPPKESDAADGPKPVPTKPVTPEAPSPPIEE--EPPQPkavvprplspytayedlkpptspiPTPPSSSPAS 397

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 605 PPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPV------------------PPTGDSGAPPVP-PTGDSGAPPVPPTGDS 665
Cdd:PLN03209  398 SKSVDAVAKPAEPDVVPSPGSASNVPEVEPAQVeakktrplspyaryedlkPPTSPSPTAPTGvSPSVSSTSSVPAVPDT 477

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1547055316 666 gAPPVPPTGDAGPPPVPPTGDSGAPPV----PPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVP 737
Cdd:PLN03209  478 -APATAATDAAAPPPANMRPLSPYAVYddlkPPTSPSPAAPVGKVAPSSTNEVVKVGNSAPPTALADEQHHAQPKP 552
Drf_FH1 pfam06346
Formin Homology Region 1; This region is found in some of the Diaphanous related formins (Drfs) ...
 602-738 1.73e-06

Formin Homology Region 1; This region is found in some of the Diaphanous related formins (Drfs). It consists of low complexity repeats of around 12 residues.


Pssm-ID: 461881 [Multi-domain]  Cd Length: 157  Bit Score: 48.33  E-value: 1.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 602 PPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTgdSGAPPVPPtgdsgaPPVPPTGDAGPPPV 681
Cdd:pfam06346   2 PPPPLPGDSSTIPLPPGACIPTPPPLPGGGGPPPPPPLPGSAAIPPPPPL--PGGTSIPP------PPPLPGAASIPPPP 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1547055316 682 PPTGDSGAPPVPP----TGDSGAPPVTPTGDSETAPVPP-TGDSGAPPVPPTGDSEAAPVPP 738
Cdd:pfam06346  74 PLPGSTGIPPPPPlpggAGIPPPPPPLPGGAGVPPPPPPlPGGPGIPPPPPFPGGPGIPPPP 135
Drf_FH1 pfam06346
Formin Homology Region 1; This region is found in some of the Diaphanous related formins (Drfs) ...
 559-703 1.80e-06

Formin Homology Region 1; This region is found in some of the Diaphanous related formins (Drfs). It consists of low complexity repeats of around 12 residues.


Pssm-ID: 461881 [Multi-domain]  Cd Length: 157  Bit Score: 48.33  E-value: 1.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 559 PVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTgdSGAPPVPPtgdsgaPPVPPTGDSGAPPVP 638
Cdd:pfam06346   3 PPPLPGDSSTIPLPPGACIPTPPPLPGGGGPPPPPPLPGSAAIPPPPPL--PGGTSIPP------PPPLPGAASIPPPPP 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1547055316 639 PTGDSGAPPVPP-TGDSGAPPVPPT--GDSGAPPVPPTGDAGP----PPVPPTGDSGAPPVPPTGDSGAPPV 703
Cdd:pfam06346  75 LPGSTGIPPPPPlPGGAGIPPPPPPlpGGAGVPPPPPPLPGGPgippPPPFPGGPGIPPPPPGMGMPPPPPF 146
FAP pfam07174
Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment ...
 667-727 1.84e-06

Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment proteins (FAP). Family members are rich in alanine and proline, are approximately 300 long, and seem to be restricted to mycobacteria. These proteins contain a fibronectin-binding motif that allows mycobacteria to bind to fibronectin in the extracellular matrix.


Pssm-ID: 429334  Cd Length: 301  Bit Score: 50.31  E-value: 1.84e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1547055316 667 APPVPPTGDAGPPPVPPTGDSGAP-PVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPP 727
Cdd:pfam07174  44 APPPPSTATAPPAPPPPPPAPAAPaPPPPPAAPNAPNAPPPPADPNAPPPPPADPNAPPPPA 105
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
536-716 2.01e-06

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 51.29  E-value: 2.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 536 TNFLRYWTLTYLALPTVTDQEATPVPPTGDSEA-----TPVPPTGDSETAPVPPTGDSGAP---PVPPTGDSGAPPVPPT 607
Cdd:COG3469    21 TLLGAAATAASVTLTAATATTVVSTTGSVVVAAsgsagSGTGTTAASSTAATSSTTSTTATataAAAAATSTSATLVATS 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 608 GDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDS 687
Cdd:COG3469   101 TASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATGGTTTTSTTTTTTSASTTPS 180

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1547055316 688 GAPPVPPTGDSG----APPVTPTGDSETAPVPP 716
Cdd:COG3469   181 ATTTATATTASGattpSATTTATTTGPPTPGLP 213
dnaA PRK14086
chromosomal replication initiator protein DnaA;
580-749 2.27e-06

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 50.98  E-value: 2.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 580 APVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGA---PPVPPTGDSGAP-PVPPTGDSG 655
Cdd:PRK14086   86 ITVDPSAGEPAPPPPHARRTSEPELPRPGRRPYEGYGGPRADDRPPGLPRQDQLPtarPAYPAYQQRPEPgAWPRAADDY 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 656 APPVPPTG-DSGAPPVPPTGDAGPP----PVPPTGDSGAPPVPPTGDSGAPPVT-PTGDSETAPVPPTG----------D 719
Cdd:PRK14086  166 GWQQQRLGfPPRAPYASPASYAPEQerdrEPYDAGRPEYDQRRRDYDHPRPDWDrPRRDRTDRPEPPPGaghvhrggpgP 245

                         170       180       190
                  ....*....|....*....|....*....|
gi 1547055316 720 SGAPPVPPTGDSEAAPVPPTDDSKEAQMPA 749
Cdd:PRK14086  246 PERDDAPVVPIRPSAPGPLAAQPAPAPGPG 275
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 587-749 2.33e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 51.33  E-value: 2.33e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  587 DSGAPPVPPTGDSGAPPvPPTGDSGAPPVppTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPvpptgdSGAPPVPPTGDSG 666
Cdd:PHA03307    15 AEGGEFFPRPPATPGDA-ADDLLSGSQGQ--LVSDSAELAAVTVVAGAAACDRFEPPTGPP------PGPGTEAPANESR 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  667 APPVPPTGDAGPPPVPPTGDSGAPPvpPTGDSGAPPVTPTGdsETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQ 746
Cdd:PHA03307    86 STPTWSLSTLAPASPAREGSPTPPG--PSSPDPPPPTPPPA--SPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAA 161


                   ...
gi 1547055316  747 MPA 749
Cdd:PHA03307   162 VAS 164
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 550-722 2.36e-06

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 50.83  E-value: 2.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 550 PTVTDQEATPV--PPTGDSEATPVPPTGDSEtAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAP--- 624
Cdd:COG5180   338 PAGVPEAASDAgqPPSAYPPAEEAVPGKPLE-QGAPRPGSSGGDGAPFQPPNGAPQPGLGRRGAPGPPMGAGDLVQAald 416

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 625 -PVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSG-------APPVPPTGDAGPPPVPPTGDS---GAPPVP 693
Cdd:COG5180   417 gGGRETASLGGAAGGAGQGPKADFVPGDAESVSGPAGLADQAGaaastamADFVAPVTDATPVDVADVLGVrpdAILGGN 496

                         170       180
                  ....*....|....*....|....*....
gi 1547055316 694 PTGDSGAPPVTPTGDSETAPVPPTGDSGA 722
Cdd:COG5180   497 VAPASGLDAETRIIEAEGAPATEDFVAAE 525
PHA03247 PHA03247
large tegument protein UL36; Provisional
 557-653 2.55e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.48  E-value: 2.55e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  557 ATPV--PPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPptgdSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTG---D 631
Cdd:PHA03247   392 ATPFarGPGGDDQTRPAAPVPASVPTPAPTPVPASAPPPP----ATPLPSAEPGSDDGPAPPPERQPPAPATEPAPddpD 467

                           90       100
                   ....*....|....*....|..
gi 1547055316  632 SGAPPVPPTGDSGAPPVPPTGD 653
Cdd:PHA03247   468 DATRKALDALRERRPPEPPGAD 489
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 548-748 2.68e-06

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 51.24  E-value: 2.68e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  548 ALPTVTDQEATPVPPTgdseaTPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPptgdSGAPPVPptgdSGAPPVP 627
Cdd:PRK10263   325 AATTATQSWAAPVEPV-----TQTPPVASVDVPPAQPTVAWQPVPGPQTGEPVIAPAP----EGYPQQS----QYAQPAV 391

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  628 PTGDSGAPPVPPTGDSGAPPvpptgdsgAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPvTPTG 707
Cdd:PRK10263   392 QYNEPLQQPVQPQQPYYAPA--------AEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAP-QSTY 462

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 1547055316  708 DSETA---PVPPTGDSGAPPVPPTGDSeAAPVPPTDDSKEAQMP 748
Cdd:PRK10263   463 QTEQTyqqPAAQEPLYQQPQPVEQQPV-VEPEPVVEETKPARPP 505
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 468-728 2.93e-06

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 50.73  E-value: 2.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 468 ATPTGYRPQDRTVSKAMIAYWTNFAKTGDPNMGDSAVPTHWEPYT-TENSGYLEITKKMGSS-----SMKRSLRTNFLRY 541
Cdd:pfam17823 166 SAPHAASPAPRTAASSTTAASSTTAASSAPTTAASSAPATLTPARgISTAATATGHPAAGTAlaavgNSSPAAGTVTAAV 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 542 WTLTYLALPTVTDQEATpVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPV-------PPTGDSGAPP 614
Cdd:pfam17823 246 GTVTPAALATLAAAAGT-VASAAGTINMGDPHARRLSPAKHMPSDTMARNPAAPMGAQAQGPIiqvstdqPVHNTAGEPT 324

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 615 VPPTGDSGAPPVPPTGDSGAPPVPPTGDSGA--PPVPPTgdsgapPVPPTgdSGAPPVPPTG-DAGPPPVPPTGDSGAPP 691
Cdd:pfam17823 325 PSPSNTTLEPNTPKSVASTNLAVVTTTKAQAkePSASPV------PVLHT--SMIPEVEATSpTTQPSPLLPTQGAAGPG 396

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1547055316 692 VPPTGDSGAPPVTPTGDSeTAPVPPTgdSGAPPVPPT 728
Cdd:pfam17823 397 ILLAPEQVATEATAGTAS-AGPTPRS--SGDPKTLAM 430
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 559-745 4.66e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 50.15  E-value: 4.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 559 PVPPTGDSEATPVPPtGDSETAPVPPTGDSGAPPVPPTGDSGAPP----VPPTGDS----GAPPVPPTGDSGAP------ 624
Cdd:pfam03154 297 PFPLTPQSSQSQVPP-GPSPAAPGQSQQRIHTPPSQSQLQSQQPPreqpLPPAPLSmphiKPPPTTPIPQLPNPqshkhp 375

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 625 -----PVPPTGDSGAPPVPPTGD----------SGAPP----VPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPvppTG 685
Cdd:pfam03154 376 phlsgPSPFQMNSNLPPPPALKPlsslsthhppSAHPPplqlMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPT---SG 452

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1547055316 686 DSGAPPVPPTGD-----SGAPPVTPTGDSETApVPPTGDSGAPPVP-------PTGDSEAAPVPPTDDSKEA 745
Cdd:pfam03154 453 LHQVPSQSPFPQhpfvpGGPPPITPPSGPPTS-TSSAMPGIQPPSSasvsssgPVPAAVSCPLPPVQIKEEA 523
PHA03264 PHA03264
envelope glycoprotein D; Provisional
 626-728 5.56e-06

envelope glycoprotein D; Provisional


Pssm-ID: 223029 [Multi-domain]  Cd Length: 416  Bit Score: 49.62  E-value: 5.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 626 VPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAP--PVPPTGDSGAPPV 703
Cdd:PHA03264  254 VPPYFEESKGYEPPPAPSGGSPAPPGDDRPEAKPEPGPVEDGAPGRETGGEGEGPEPAGRDGAAGgePKPGPPRPAPDAD 333

                          90       100
                  ....*....|....*....|....*
gi 1547055316 704 TPTGDSETAPVPPTGDSGAPPVPPT 728
Cdd:PHA03264  334 RPEGWPSLEAITFPPPTPATPAVPR 358
PTZ00429 PTZ00429
beta-adaptin; Provisional
 563-690 6.63e-06

beta-adaptin; Provisional


Pssm-ID: 240415 [Multi-domain]  Cd Length: 746  Bit Score: 49.55  E-value: 6.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 563 TGDSEATPVPPTgdsetapvPPTGDSGAPPVPPTGDSGAPPVPPTGD-SGAPPVPPTGDSGAPPVPPTGD-SGAPPVPPT 640
Cdd:PTZ00429  613 TEDDDAVELPST--------PSMGTQDGSPAPSAAPAGYDIFEFAGDgTGAPHPVASGSNGAQHADPLGDlFSGLPSTVG 684

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1547055316 641 GDSGAPPVPPtgDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAP 690
Cdd:PTZ00429  685 ASSPAFQAAS--GSQAPASPPTAASAIEDLFANGMGSGSQTVPLPISAAP 732
Pro-rich pfam15240
Proline-rich protein; This family includes several eukaryotic proline-rich proteins.
 561-694 6.93e-06

Proline-rich protein; This family includes several eukaryotic proline-rich proteins.


Pssm-ID: 464580 [Multi-domain]  Cd Length: 167  Bit Score: 46.95  E-value: 6.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 561 PPTGDSEATPVPPTGdsETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPP-----VPPTGDSGAPPvPPTGDSGAP 635
Cdd:pfam15240  38 QSQQGGQGPQGPPPG--GFPPQPPASDDPPGPPPPGGPQQPPPQGGKQKPQGPPpqggpRPPPGKPQGPP-PQGGNQQQG 114

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1547055316 636 PVPPTGDSGAPPvpptgDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGdsGAPPVPP 694
Cdd:pfam15240 115 PPPPGKPQGPPP-----QGGGPPPQGGNQQGPPPPPPGNPQGPPQRPPQP--GNPQGPP 166
MISS pfam15822
MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic ...
 550-726 7.76e-06

MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic MAPK-interacting and spindle-stabilising protein-like proteins. MISS is rich in prolines and has four potential MAPK-phosphorylation sites, a MAPK-docking site, a PEST sequence (PEST motif) and a bipartite nuclear localization signal. The endogenous protein accumulates during mouse meiotic maturation and is found as discrete dots on the MII spindle. MISS is the first example of a physiological MAPK-substrate that is stabilized in MII that specifically regulates MII spindle integrity during the CSF arrest.


Pssm-ID: 318115 [Multi-domain]  Cd Length: 238  Bit Score: 48.06  E-value: 7.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 550 PTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVP--PTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVP 627
Cdd:pfam15822  39 PSAPPAVPSGLPPSTAPSTVPFGPAPTGMYPSIPLTGPSPGPPAPfpPSGPSCPPPGGPYPAPTVPGPGPIGPYPTPNMP 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 628 ----------PTGDSGAPPVPPTGDSGAPPVPPT--GDSGAP--PVPPTGDSGAPPvPPTGDAGPPPVP----PTGDSG- 688
Cdd:pfam15822 119 fpelprpygaPTDPAAAAPSGPWGSMSSGPWAPGmgGQYPAPnmPYPSPGPYPAVP-PPQSPGAAPPVPwgtvPPGPWGp 197

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1547055316 689 -APPVPPTGDSGAPPVTPTGDSETApvPPTGDSGAPPVP 726
Cdd:pfam15822 198 pAPYPDPTGSYPMPGLYPTPNNPFQ--VPSGPSGAPPMP 234
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 601-750 9.75e-06

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 48.61  E-value: 9.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 601 APPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPtgdsgAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPP 680
Cdd:NF040712  193 GRPLRPLATVPRLAREPADARPEEVEPAPAAEGAPATDS-----DPAEAGTPDDLASARRRRAGVEQPEDEPVGPGAAPA 267

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1547055316 681 VPPTGDSGAPPVPPtgdsgaPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEA--APVPPTDDSKEAQMPAV 750
Cdd:NF040712  268 AEPDEATRDAGEPP------APGAAETPEAAEPPAPAPAAPAAPAAPEAEEPArpEPPPAPKPKRRRRRASV 333
PHA03264 PHA03264
envelope glycoprotein D; Provisional
 604-706 1.01e-05

envelope glycoprotein D; Provisional


Pssm-ID: 223029 [Multi-domain]  Cd Length: 416  Bit Score: 48.46  E-value: 1.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 604 VPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAP--PVPPTGDAGPPPV 681
Cdd:PHA03264  254 VPPYFEESKGYEPPPAPSGGSPAPPGDDRPEAKPEPGPVEDGAPGRETGGEGEGPEPAGRDGAAGgePKPGPPRPAPDAD 333

                          90       100
                  ....*....|....*....|....*
gi 1547055316 682 PPTGDSGAPPVPPTGDSGAPPVTPT 706
Cdd:PHA03264  334 RPEGWPSLEAITFPPPTPATPAVPR 358
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 539-739 1.05e-05

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 48.91  E-value: 1.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 539 LRYWTLTYLALPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVP---------------PTGDSGAPPVPPTGDSGAPP 603
Cdd:COG5180   154 LLQRSDPILAKDPDGDSASTLPPPAEKLDKVLTEPRDALKDSPEKldrpkvevkdeaqeePPDLTGGADHPRPEAASSPK 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 604 VPPTGDSGAPPVPPTGDSGAPPVPPtGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPP 683
Cdd:COG5180   234 VDPPSTSEARSRPATVDAQPEMRPP-ADAKERRRAAIGDTPAAEPPGLPVLEAGSEPQSDAPEAETARPIDVKGVASAPP 312

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1547055316 684 TGDSGAPPvPPTGDSGAPpvTPTGDSETAPVPPTGDSGAPPvPPTGDSEAAPVPPT 739
Cdd:COG5180   313 ATRPVRPP-GGARDPGTP--RPGQPTERPAGVPEAASDAGQ-PPSAYPPAEEAVPG 364
PHA03264 PHA03264
envelope glycoprotein D; Provisional
 582-695 1.20e-05

envelope glycoprotein D; Provisional


Pssm-ID: 223029 [Multi-domain]  Cd Length: 416  Bit Score: 48.46  E-value: 1.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 582 VPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAP--PVPPTGDSGAPPV 659
Cdd:PHA03264  254 VPPYFEESKGYEPPPAPSGGSPAPPGDDRPEAKPEPGPVEDGAPGRETGGEGEGPEPAGRDGAAGgePKPGPPRPAPDAD 333

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1547055316 660 PPTGDSGAPPVPptgdaGPPPVPptgdsgAPPVPPT 695
Cdd:PHA03264  334 RPEGWPSLEAIT-----FPPPTP------ATPAVPR 358
PLN02217 PLN02217
probable pectinesterase/pectinesterase inhibitor
 481-650 1.23e-05

probable pectinesterase/pectinesterase inhibitor


Pssm-ID: 215130 [Multi-domain]  Cd Length: 670  Bit Score: 48.55  E-value: 1.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 481 SKAMIAY-WTNFAKTGDPN--MGDSAVPTHWEPY------------TTENSGY-LEITKKMGSSSMKRSLRTNFLRYWTL 544
Cdd:PLN02217  462 SKAYLGRpWKEYSRTIIMNtfIPDFVPPEGWQPWlgdfglntlfysEVQNTGPgAAITKRVTWPGIKKLSDEEILKFTPA 541

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 545 TYLALPTVTDQEATPVPP---TGDSEATPVPPTGDSETAPVPPTGDSGAPPV-----PPTGDSGAPPVPPTGDSGAPPVP 616
Cdd:PLN02217  542 QYIQGDAWIPGKGVPYIPglfAGNPGSTNSTPTGSAASSNTTFSSDSPSTVVapstsPPAGHLGSPPATPSKIVSPSTSP 621

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1547055316 617 PTGDSGAPPVPPtgdsgAPPVPPTGDSGAPPVPP 650
Cdd:PLN02217  622 PASHLGSPSTTP-----SSPESSIKVASTETASP 650
PHA03264 PHA03264
envelope glycoprotein D; Provisional
 571-673 1.59e-05

envelope glycoprotein D; Provisional


Pssm-ID: 223029 [Multi-domain]  Cd Length: 416  Bit Score: 48.08  E-value: 1.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 571 VPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAP--PVPPTGDSGAPPV 648
Cdd:PHA03264  254 VPPYFEESKGYEPPPAPSGGSPAPPGDDRPEAKPEPGPVEDGAPGRETGGEGEGPEPAGRDGAAGgePKPGPPRPAPDAD 333

                          90       100
                  ....*....|....*....|....*
gi 1547055316 649 PPTGDSGAPPVPPTGDSGAPPVPPT 673
Cdd:PHA03264  334 RPEGWPSLEAITFPPPTPATPAVPR 358
PLN02217 PLN02217
probable pectinesterase/pectinesterase inhibitor
 600-712 1.67e-05

probable pectinesterase/pectinesterase inhibitor


Pssm-ID: 215130 [Multi-domain]  Cd Length: 670  Bit Score: 48.16  E-value: 1.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 600 GAPPVPP--TGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDsgappvPPTGDSGAPPVPPTGDSGAPPVPPTGDAG 677
Cdd:PLN02217  554 GVPYIPGlfAGNPGSTNSTPTGSAASSNTTFSSDSPSTVVAPSTS------PPAGHLGSPPATPSKIVSPSTSPPASHLG 627

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1547055316 678 PPPVPPtgdsgAPPVPPTGDSGAPPVTPTGDSETA 712
Cdd:PLN02217  628 SPSTTP-----SSPESSIKVASTETASPESSIKVA 657
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 650-750 1.71e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 48.17  E-value: 1.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 650 PTGDSGAPPVPPTgDSGAPPVPPTGDAGPPPVPPTGDSGAPPvPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTG 729
Cdd:PRK14951  366 PAAAAEAAAPAEK-KTPARPEAAAPAAAPVAQAAAAPAPAAA-PAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPA 443

                          90       100
                  ....*....|....*....|.
gi 1547055316 730 DSEAAPVPPTDDSKEAQMPAV 750
Cdd:PRK14951  444 AVALAPAPPAQAAPETVAIPV 464
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 542-750 1.77e-05

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 48.14  E-value: 1.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 542 WTLTYLALPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPvPPTGDSGAPPvpPTGDS 621
Cdd:COG5180   259 ADAKERRRAAIGDTPAAEPPGLPVLEAGSEPQSDAPEAETARPIDVKGVASAPPATRPVRPP-GGARDPGTPR--PGQPT 335

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 622 GAPPVPPTGDSGAPPvPPTGDSGAPPVPPtGDSGAPPVPPTGDSGAPPVP-PTGDAGPPPVPPTGDSGAPPVPPtgdsgA 700
Cdd:COG5180   336 ERPAGVPEAASDAGQ-PPSAYPPAEEAVP-GKPLEQGAPRPGSSGGDGAPfQPPNGAPQPGLGRRGAPGPPMGA-----G 408

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1547055316 701 PPVTPTGDsetAPVPPTGD-----------SGAPPVPPTGDSEAAPVPPTDDSKEAQMPAV 750
Cdd:COG5180   409 DLVQAALD---GGGRETASlggaaggagqgPKADFVPGDAESVSGPAGLADQAGAAASTAM 466
PTZ00429 PTZ00429
beta-adaptin; Provisional
 554-681 1.85e-05

beta-adaptin; Provisional


Pssm-ID: 240415 [Multi-domain]  Cd Length: 746  Bit Score: 48.39  E-value: 1.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 554 DQEATPVPPTgdseatpvPPTGDSETAPVPPTGDSGAPPVPPTGD-SGAPPVPPTGDSGAPPVPPTGD-SGAPPVPPTGD 631
Cdd:PTZ00429  615 DDDAVELPST--------PSMGTQDGSPAPSAAPAGYDIFEFAGDgTGAPHPVASGSNGAQHADPLGDlFSGLPSTVGAS 686

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1547055316 632 SGAPPVPPtgDSGAPPVPPTGDSGAPPVPPTG-DSGAPPVPPTGDAGPPPV 681
Cdd:PTZ00429  687 SPAFQAAS--GSQAPASPPTAASAIEDLFANGmGSGSQTVPLPISAAPQSA 735
DamX COG3266
Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell ...
 532-743 1.86e-05

Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442497 [Multi-domain]  Cd Length: 455  Bit Score: 47.92  E-value: 1.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 532 RSLRTNFLRYWTLTYLALPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPtgdSG 611
Cdd:COG3266   146 LPLLTLLIVLPLLEEQLLLLALQDIQGTLQALGAVAALLGLRKAEEALALRAGSAAADALALLLLLLASALGEAV---AA 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 612 APPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPvPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPT--GDSGA 689
Cdd:COG3266   223 AAELAALALLAAGAAEVLTARLVLLLLIIGSALKAP-SQASSASAPATTSLGEQQEVSLPPAVAAQPAAAAAAqpSAVAL 301

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1547055316 690 PPVPPTGDSGAPPVTPT--GDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSK 743
Cdd:COG3266   302 PAAPAAAAAAAAPAEAAapQPTAAKPVVTETAAPAAPAPEAAAAAAAPAAPAVAKK 357
PRK11633 PRK11633
cell division protein DedD; Provisional
 613-736 2.03e-05

cell division protein DedD; Provisional


Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 46.53  E-value: 2.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 613 PPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAppvPPTGDSGAPPVPPTgDSGAPPVPPtgDAGPPPVPPTgdsGAPPV 692
Cdd:PRK11633   42 PLVPKPGDRDEPDMMPAATQALPTQPPEGAAEA---VRAGDAAAPSLDPA-TVAPPNTPV--EPEPAPVEPP---KPKPV 112

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1547055316 693 PPTgdsgAPPVTPTGDSETAPVPPtgdsgaPPVPPTGDSEAAPV 736
Cdd:PRK11633  113 EKP----KPKPKPQQKVEAPPAPK------PEPKPVVEEKAAPT 146
PLN02217 PLN02217
probable pectinesterase/pectinesterase inhibitor
 655-742 2.60e-05

probable pectinesterase/pectinesterase inhibitor


Pssm-ID: 215130 [Multi-domain]  Cd Length: 670  Bit Score: 47.78  E-value: 2.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 655 GAPPVPP--TGDSGAPPVPPTGDAGPPPVPPTGDSGAPPV-----PPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPP 727
Cdd:PLN02217  554 GVPYIPGlfAGNPGSTNSTPTGSAASSNTTFSSDSPSTVVapstsPPAGHLGSPPATPSKIVSPSTSPPASHLGSPSTTP 633

                          90
                  ....*....|....*
gi 1547055316 728 TGDSEAAPVPPTDDS 742
Cdd:PLN02217  634 SSPESSIKVASTETA 648
Pro-rich pfam15240
Proline-rich protein; This family includes several eukaryotic proline-rich proteins.
 577-727 2.61e-05

Proline-rich protein; This family includes several eukaryotic proline-rich proteins.


Pssm-ID: 464580 [Multi-domain]  Cd Length: 167  Bit Score: 45.41  E-value: 2.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 577 SETAPVPPTGDSGAPPVPPTGDSgapPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPpvPPTGDSGAPPVPPTGdsga 656
Cdd:pfam15240  33 SEEEGQSQQGGQGPQGPPPGGFP---PQPPASDDPPGPPPPGGPQQPPPQGGKQKPQGP--PPQGGPRPPPGKPQG---- 103

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1547055316 657 pPVPPTGDSGAPPVPPTGDAGPPPvpptgdSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTgDSGAPPVPP 727
Cdd:pfam15240 104 -PPPQGGNQQQGPPPPGKPQGPPP------QGGGPPPQGGNQQGPPPPPPGNPQGPPQRPP-QPGNPQGPP 166
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 615-705 2.71e-05

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 47.96  E-value: 2.71e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  615 VPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTgdsgappvpPTGDAGPPPVPPTGDSGAPPVPP 694
Cdd:PRK12270    38 PGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPK---------PAAAAAAAAAPAAPPAAAAAAAP 108

                           90
                   ....*....|.
gi 1547055316  695 TGDSGAPPVTP 705
Cdd:PRK12270   109 AAAAVEDEVTP 119
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 633-716 2.73e-05

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 47.30  E-value: 2.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 633 GAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPvtPTGDSETA 712
Cdd:NF041121   16 GRAAAPPSPEGPAPTAASQPATPPPPAAPPSPPGDPPEPPAPEPAPLPAPYPGSLAPPPPPPPGPAGAAP--GAALPVRV 93


                  ....
gi 1547055316 713 PVPP 716
Cdd:NF041121   94 PAPP 97
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 557-668 2.78e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 47.37  E-value: 2.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 557 ATPVPPTGDSEATPVP----PTGDSETAPVPPTgdSGAPPVPPTGDSGAPPVPPtgdSGAPPVPPTgdSGAPPVPPTGDS 632
Cdd:PRK14959  385 AAEGPASGGAATIPTPgtqgPQGTAPAAGMTPS--SAAPATPAPSAAPSPRVPW---DDAPPAPPR--SGIPPRPAPRMP 457

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1547055316 633 GAPPVP--PTGDSGAPPVPPTgdSGAPPVPPTGDSGAP 668
Cdd:PRK14959  458 EASPVPgaPDSVASASDAPPT--LGDPSDTAEHTPSGP 493
motB PRK12799
flagellar motor protein MotB; Reviewed
 608-732 2.83e-05

flagellar motor protein MotB; Reviewed


Pssm-ID: 183756 [Multi-domain]  Cd Length: 421  Bit Score: 47.40  E-value: 2.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 608 GDSGAPPV---PPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPT 684
Cdd:PRK12799  294 DTHGTVPVaavTPSSAVTQSSAITPSSAAIPSPAVIPSSVTTQSATTTQASAVALSSAGVLPSDVTLPGTVALPAAEPVN 373

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1547055316 685 GDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSE 732
Cdd:PRK12799  374 MQPQPMSTTETQQSSTGNITSTANGPTTSLPAAPASNIPVSPTSRDAQ 421
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 600-695 3.25e-05

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 47.30  E-value: 3.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 600 GAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPvpptGDAGPP 679
Cdd:NF041121   16 GRAAAPPSPEGPAPTAASQPATPPPPAAPPSPPGDPPEPPAPEPAPLPAPYPGSLAPPPPPPPGPAGAAP----GAALPV 91

                          90
                  ....*....|....*.
gi 1547055316 680 PVPptgdsgAPPVPPT 695
Cdd:NF041121   92 RVP------APPALPN 101
Pro-rich pfam15240
Proline-rich protein; This family includes several eukaryotic proline-rich proteins.
 623-738 3.30e-05

Proline-rich protein; This family includes several eukaryotic proline-rich proteins.


Pssm-ID: 464580 [Multi-domain]  Cd Length: 167  Bit Score: 45.03  E-value: 3.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 623 APPVPPTGdsGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPvpPTGDAGPP------PVPPTGDSGAPPVPPTG 696
Cdd:pfam15240  45 GPQGPPPG--GFPPQPPASDDPPGPPPPGGPQQPPPQGGKQKPQGPP--PQGGPRPPpgkpqgPPPQGGNQQQGPPPPGK 120

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1547055316 697 DSGAPPvtptgdSETAPVPPTGDSGAPPVPPTGDSEAAPVPP 738
Cdd:pfam15240 121 PQGPPP------QGGGPPPQGGNQQGPPPPPPGNPQGPPQRP 156
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 548-660 3.64e-05

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 46.68  E-value: 3.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 548 ALPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPvPPTGDSGAPPVP 627
Cdd:NF040712  226 APATDSDPAEAGTPDDLASARRRRAGVEQPEDEPVGPGAAPAAEPDEATRDAGEPPAPGAAETPEAA-EPPAPAPAAPAA 304

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1547055316 628 PTGDSGAPPVPPtgdSGAPPVPPTGDSGAPPVP 660
Cdd:NF040712  305 PAAPEAEEPARP---EPPPAPKPKRRRRRASVP 334
PRK14954 PRK14954
DNA polymerase III subunits gamma and tau; Provisional
 598-699 3.74e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184918 [Multi-domain]  Cd Length: 620  Bit Score: 47.25  E-value: 3.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 598 DSGAPPVPPTGdsgappvPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPvpptgdSGAPPVPPtgdag 677
Cdd:PRK14954  377 DGGVAPSPAGS-------PDVKKKAPEPDLPQPDRHPGPAKPEAPGARPAELPSPASAPTP------EQQPPVAR----- 438

                          90       100
                  ....*....|....*....|..
gi 1547055316 678 PPPVPPTGDSGAPPVPPTGDSG 699
Cdd:PRK14954  439 SAPLPPSPQASAPRNVASGKPG 460
Gag_spuma pfam03276
Spumavirus gag protein;
560-748 3.92e-05

Spumavirus gag protein;


Pssm-ID: 460872 [Multi-domain]  Cd Length: 614  Bit Score: 47.05  E-value: 3.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 560 VPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGappvPPTGDSGAPPVPPTgdSGAPPVPP 639
Cdd:pfam03276 186 IPPGASFSGLPSLPAIGGIHLPAIPGIHARAPPGNIARSLGDDIMPSLGDAG----MPQPRFAFHPGNPF--AEAEGHPF 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 640 TGDSG----APPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTG------------DSGAPPV 703
Cdd:pfam03276 260 AEAEGerprDIPRAPRIDAPSAPAIPAIQPIAPPMIPPIGAPIPIPHGASIPGEHIRNPREepirlgreapaiDGRFAPA 339

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1547055316 704 TPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMP 748
Cdd:pfam03276 340 IDDLFCRIINALLCGIIGALLGGGDCISLDPADAILFDRAVAQLF 384
PHA03378 PHA03378
EBNA-3B; Provisional
 569-727 3.92e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 47.37  E-value: 3.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 569 TPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPP--VPPTgdsgaPPVPPTGDSGAP 646
Cdd:PHA03378  650 TPHQPPQVEITPYKPTWTQIGHIPYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPpaAPPG-----RAQRPAAATGRA 724

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 647 PVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTgdsgaPPVPPTGDSGAPpvTPTGDSETAPVPPTGDSGAP-PV 725
Cdd:PHA03378  725 RPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPG-----RARPPAAAPGAP--TPQPPPQAPPAPQQRPRGAPtPQ 797


                  ..
gi 1547055316 726 PP 727
Cdd:PHA03378  798 PP 799
PHA03378 PHA03378
EBNA-3B; Provisional
 536-678 4.06e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 47.37  E-value: 4.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 536 TNFLRYWTLTYLALPTVTDQEATP--VPPTG----DSEATPVPPTGDSETAPVPPTGDSGAPPvPPTGDSGAPPVPPTGD 609
Cdd:PHA03378  683 TMLPIQWAPGTMQPPPRAPTPMRPpaAPPGRaqrpAAATGRARPPAAAPGRARPPAAAPGRAR-PPAAAPGRARPPAAAP 761

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1547055316 610 SGAPPvpPTGDSGAP-PVPPTGdsgAPPVPPTGDSGAP-PVPPtgdsgaPPVPPTGDSGAPPVPPtGDAGP 678
Cdd:PHA03378  762 GRARP--PAAAPGAPtPQPPPQ---APPAPQQRPRGAPtPQPP------PQAGPTSMQLMPRAAP-GQQGP 820
PRK11633 PRK11633
cell division protein DedD; Provisional
 591-714 4.11e-05

cell division protein DedD; Provisional


Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 45.38  E-value: 4.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 591 PPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAppvPPTGDSGAPPVPPTgDSGAPPVPPtgDSGAPPVPPtgdsgaPPV 670
Cdd:PRK11633   42 PLVPKPGDRDEPDMMPAATQALPTQPPEGAAEA---VRAGDAAAPSLDPA-TVAPPNTPV--EPEPAPVEP------PKP 109

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1547055316 671 PPTgdagPPPVPPTGDSGAPPVPPTgdsGAPPVTPTGDSETAPV 714
Cdd:PRK11633  110 KPV----EKPKPKPKPQQKVEAPPA---PKPEPKPVVEEKAAPT 146
PLN02217 PLN02217
probable pectinesterase/pectinesterase inhibitor
 589-694 4.32e-05

probable pectinesterase/pectinesterase inhibitor


Pssm-ID: 215130 [Multi-domain]  Cd Length: 670  Bit Score: 47.01  E-value: 4.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 589 GAPPVPP--TGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDsgappvPPTGDSGAPPVPPTGDSGAPPVPPTGDSG 666
Cdd:PLN02217  554 GVPYIPGlfAGNPGSTNSTPTGSAASSNTTFSSDSPSTVVAPSTS------PPAGHLGSPPATPSKIVSPSTSPPASHLG 627

                          90       100
                  ....*....|....*....|....*...
gi 1547055316 667 APPVPPTGdagppPVPPTGDSGAPPVPP 694
Cdd:PLN02217  628 SPSTTPSS-----PESSIKVASTETASP 650
FAP pfam07174
Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment ...
 634-701 5.10e-05

Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment proteins (FAP). Family members are rich in alanine and proline, are approximately 300 long, and seem to be restricted to mycobacteria. These proteins contain a fibronectin-binding motif that allows mycobacteria to bind to fibronectin in the extracellular matrix.


Pssm-ID: 429334  Cd Length: 301  Bit Score: 46.07  E-value: 5.10e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1547055316 634 APPVPPTGDSGAPPVPPTGDSGAP-PVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPvPPTGDSGAP 701
Cdd:pfam07174  44 APPPPSTATAPPAPPPPPPAPAAPaPPPPPAAPNAPNAPPPPADPNAPPPPPADPNAPP-PPAVDPNAP 111
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 553-716 6.03e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 46.70  E-value: 6.03e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  553 TDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSG----APPVPPTGDSGAPPVPPTGDSGAPPVPP 628
Cdd:PHA03307   782 RGAGSSPPVRAEAAFRRPGRLRRSGPAADAASRTASKRKSRSHTPDGGsessGPARPPGAAARPPPARSSESSKSKPAAA 861

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  629 TGDSGAPPvpptGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTgdAGPPPVPPTGDSGAPPVPPTGDSGAPPVtPTGD 708
Cdd:PHA03307   862 GGRARGKN----GRRRPRPPEPRARPGAAAPPKAAAAAPPAGAPA--PRPRPAPRVKLGPMPPGGPDPRGGFRRV-PPGD 934


                   ....*...
gi 1547055316  709 SETaPVPP 716
Cdd:PHA03307   935 LHT-PAPS 941
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
597-717 6.27e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 46.31  E-value: 6.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 597 GDSGAPPVPPTgdsgAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPP--TGDSGAPPVPPTGDSGAPPVPPTG 674
Cdd:PRK14971  366 GDDASGGRGPK----QHIKPVFTQPAAAPQPSAAAAASPSPSQSSAAAQPSAPQsaTQPAGTPPTVSVDPPAAVPVNPPS 441

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1547055316 675 dAGPPPVPPTGDSGAPPVPPTG-DSGAPPVT---------PTGDSETAPVPPT 717
Cdd:PRK14971  442 -TAPQAVRPAQFKEEKKIPVSKvSSLGPSTLrpiqekaeqATGNIKEAPTGTQ 493
Gag_spuma pfam03276
Spumavirus gag protein;
580-707 6.39e-05

Spumavirus gag protein;


Pssm-ID: 460872 [Multi-domain]  Cd Length: 614  Bit Score: 46.28  E-value: 6.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 580 APVPPTGDSGAPPVppTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPvPPTGDSGAPPVPPTGDSGAP-- 657
Cdd:pfam03276 176 AEISPGAQGGIPPG--ASFSGLPSLPAIGGIHLPAIPGIHARAPPGNIARSLGDDIM-PSLGDAGMPQPRFAFHPGNPfa 252

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 658 ------------------PVPPTGDSGAPPVPPTGDAGPPPVPPTgdSGAPPVPPTGDS--GAPPVTPTG 707
Cdd:pfam03276 253 eaeghpfaeaegerprdiPRAPRIDAPSAPAIPAIQPIAPPMIPP--IGAPIPIPHGASipGEHIRNPRE 320
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 566-733 6.51e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 46.70  E-value: 6.51e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  566 SEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSG----APPVPPTGDSGAPPVPPTG 641
Cdd:PHA03307   773 ALLEPAEPQRGAGSSPPVRAEAAFRRPGRLRRSGPAADAASRTASKRKSRSHTPDGGsessGPARPPGAAARPPPARSSE 852

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  642 DSGAPPVPPTGDSGA-------PPVPPTGDSGAPPVPPTGDAGPPPVPPTgdSGAPPVPPTGDSGAPPVTPTGDSETAPV 714
Cdd:PHA03307   853 SSKSKPAAAGGRARGkngrrrpRPPEPRARPGAAAPPKAAAAAPPAGAPA--PRPRPAPRVKLGPMPPGGPDPRGGFRRV 930

                          170
                   ....*....|....*....
gi 1547055316  715 PPtGDSgAPPVPPTGDSEA 733
Cdd:PHA03307   931 PP-GDL-HTPAPSAAALAA 947
PTZ00429 PTZ00429
beta-adaptin; Provisional
 612-742 6.79e-05

beta-adaptin; Provisional


Pssm-ID: 240415 [Multi-domain]  Cd Length: 746  Bit Score: 46.46  E-value: 6.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 612 APPVPPTGDSGAPPVPPTGDSGAPPVPPTGD-SGAPPVPPTGDSGAPPVPPTGD--SGappVPPTGDAGPPPVPPTGDSG 688
Cdd:PTZ00429  621 LPSTPSMGTQDGSPAPSAAPAGYDIFEFAGDgTGAPHPVASGSNGAQHADPLGDlfSG---LPSTVGASSPAFQAASGSQ 697

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1547055316 689 APPVPPTgdsgappVTPTGDSETAPVPPTGDSGAPpvpptGDSEAAPVPPTDDS 742
Cdd:PTZ00429  698 APASPPT-------AASAIEDLFANGMGSGSQTVP-----LPISAAPQSADRDT 739
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 580-752 6.97e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 46.70  E-value: 6.97e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  580 APVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSG----APPVPPTGDSGAPPVPPTGDSG 655
Cdd:PHA03307   776 EPAEPQRGAGSSPPVRAEAAFRRPGRLRRSGPAADAASRTASKRKSRSHTPDGGsessGPARPPGAAARPPPARSSESSK 855

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  656 APPVPPTGDSGAPPvpptGDAGPPPVPPTGDSGAPPvPPTGDSGAPPVTPTGDSEtAPVPPTGDSGAPPVPPTGDSEAAP 735
Cdd:PHA03307   856 SKPAAAGGRARGKN----GRRRPRPPEPRARPGAAA-PPKAAAAAPPAGAPAPRP-RPAPRVKLGPMPPGGPDPRGGFRR 929

                          170
                   ....*....|....*..
gi 1547055316  736 VPPTDDSKEAQMPAVIR 752
Cdd:PHA03307   930 VPPGDLHTPAPSAAALA 946
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 475-717 7.55e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 46.45  E-value: 7.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 475 PQDRTVSKAMIAYWTNFAKTGDPNMGDSAVPTHWEPYTTENSGYLEITKKMGSSSMKRSLRTNFLRYWTLTYLALPTVTD 554
Cdd:pfam05109 600 PQANTTNHTLGGTSSTPVVTSPPKNATSAVTTGQHNITSSSTSSMSLRPSSISETLSPSTSDNSTSHMPLLTSAHPTGGE 679

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 555 QEATPVPPTGD----SEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTgdsgAPPVPPTGDSGAPPVPPTG 630
Cdd:pfam05109 680 NITQVTPASTSthhvSTSSPAPRPGTTSQASGPGNSSTSTKPGEVNVTKGTPPKNAT----SPQAPSGQKTAVPTVTSTG 755

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 631 ---DSGAPPVPPTGDSGAPPVPPTGDSGappvpptGDSGAPPVPPTGDAGPPPvpptgdSGAPPVPPTGDSGAPPVTPTg 707
Cdd:pfam05109 756 gkaNSTTGGKHTTGHGARTSTEPTTDYG-------GDSTTPRTRYNATTYLPP------STSSKLRPRWTFTSPPVTTA- 821

                         250
                  ....*....|
gi 1547055316 708 dSETAPVPPT 717
Cdd:pfam05109 822 -QATVPVPPT 830
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 599-740 7.78e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 46.32  E-value: 7.78e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  599 SGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSG----APPVPPTG 674
Cdd:PHA03307   762 SLVPAKLAEALALLEPAEPQRGAGSSPPVRAEAAFRRPGRLRRSGPAADAASRTASKRKSRSHTPDGGsessGPARPPGA 841

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1547055316  675 DAGPPPVPPTGDSGAPPVPPTGDSGAPPvtptGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTD 740
Cdd:PHA03307   842 AARPPPARSSESSKSKPAAAGGRARGKN----GRRRPRPPEPRARPGAAAPPKAAAAAPPAGAPAP 903
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 639-742 7.79e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 46.21  E-value: 7.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 639 PTGDSGAPPvpptGDSGAPPvppTGDSGAPPVPPTGDAGPPPVPP----TGDSGAPPVPPTGDSGAPPVTPtgdSETAPV 714
Cdd:PRK14959  373 PSGGGASAP----SGSAAEG---PASGGAATIPTPGTQGPQGTAPaagmTPSSAAPATPAPSAAPSPRVPW---DDAPPA 442

                          90       100
                  ....*....|....*....|....*...
gi 1547055316 715 PPTgdSGAPPVPPTGDSEAAPVPPTDDS 742
Cdd:PRK14959  443 PPR--SGIPPRPAPRMPEASPVPGAPDS 468
PHA03247 PHA03247
large tegument protein UL36; Provisional
 547-700 8.00e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.47  E-value: 8.00e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  547 LALPTVTDQ-EATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAP---PVPPTGDSG 622
Cdd:PHA03247  2886 LARPAVSRStESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGepsGAVPQPWLG 2965

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  623 A-------------PPVPPTGDSGAPPVPPTGDSGAPPVPPTG-------DSGAPPV-------PPTGDSGA-------- 667
Cdd:PHA03247  2966 AlvpgrvavprfrvPQPAPSREAPASSTPPLTGHSLSRVSSWAsslalheETDPPPVslkqtlwPPDDTEDSdadslfds 3045

                          170       180       190
                   ....*....|....*....|....*....|....
gi 1547055316  668 -PPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGA 700
Cdd:PHA03247  3046 dSERSDLEALDPLPPEPHDPFAHEPDPATPEAGA 3079
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 631-713 8.13e-05

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 46.42  E-value: 8.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  631 DSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSE 710
Cdd:PRK12270    37 GPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAAVEDE 116


                   ...
gi 1547055316  711 TAP 713
Cdd:PRK12270   117 VTP 119
PLN02217 PLN02217
probable pectinesterase/pectinesterase inhibitor
 633-742 8.28e-05

probable pectinesterase/pectinesterase inhibitor


Pssm-ID: 215130 [Multi-domain]  Cd Length: 670  Bit Score: 46.24  E-value: 8.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 633 GAPPVPP--TGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDagpppvPPTGDSGAPPVPPT---GDSGAPPVTPTG 707
Cdd:PLN02217  554 GVPYIPGlfAGNPGSTNSTPTGSAASSNTTFSSDSPSTVVAPSTS------PPAGHLGSPPATPSkivSPSTSPPASHLG 627

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1547055316 708 DSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDS 742
Cdd:PLN02217  628 SPSTTPSSPESSIKVASTETASPESSIKVASTESS 662
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 557-740 8.96e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 46.06  E-value: 8.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 557 ATPVPPTGDSEATPVPP--TGDSETAPVPPTGDSGAPpVPPTGDSGAPPVPPTgdsgAPPVPPTGDSGAPPVPPTGDSGA 634
Cdd:pfam05109 440 AAPNTTTGLPSSTHVPTnlTAPASTGPTVSTADVTSP-TPAGTTSGASPVTPS----PSPRDNGTESKAPDMTSPTSAVT 514

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 635 PPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPP--VPPTGDSGAPPVPPTGDSGApPVTPTGDSETA 712
Cdd:pfam05109 515 TPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPavTTPTPNATIPTLGKTSPTSA-VTTPTPNATSP 593

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1547055316 713 PVPPTGDSGAPPVPPTGDSEAAPV---PPTD 740
Cdd:pfam05109 594 TVGETSPQANTTNHTLGGTSSTPVvtsPPKN 624
PHA03418 PHA03418
hypothetical E4 protein; Provisional
 592-727 1.03e-04

hypothetical E4 protein; Provisional


Pssm-ID: 177646 [Multi-domain]  Cd Length: 230  Bit Score: 44.34  E-value: 1.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 592 PVPPTGDSGAPPVPPTGDSGAPPVPPTgdSGAPPVPPTGDSgAPPVPPT----GDSGAPPVPPTGDSGAPPVPPTGDSGA 667
Cdd:PHA03418   34 PLLPAPHHPNPQEDPDKNPSPPPDPPL--TPRPPAQPNGHN-KPPVTKQpggeGTEEDHQAPLAADADDDPRPGKRSKAD 110

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 668 PPVPPTGDAGPPPV-------PPTGDSGAPPvPPTGDSGAPPvtPTGDSETAPVPPTGD---SGAPPVPP 727
Cdd:PHA03418  111 EHGPAPGRAALAPFkldldqdPLHGDPDPPP-GATGGQGEEP--PEGGEESQPPLGEGEgavEGHPPPLP 177
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 562-711 1.19e-04

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 44.85  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 562 PTGDSEATPVPPTgdseTAPVPPTgDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPtgdsgaPPVPPTGDSGAPPVPPTg 641
Cdd:PHA02682   76 PSGQSPLAPSPAC----AAPAPAC-PACAPAAPAPAVTCPAPAPACPPATAPTCPP------PAVCPAPARPAPACPPS- 143

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1547055316 642 dsgAPPVPPtgdsgAPPVP-PTGDSGAPPVPPTGDAGPPPVP----PTGDSgAPPVPPTGDSGAPPVTPTGDSET 711
Cdd:PHA02682  144 ---TRQCPP-----APPLPtPKPAPAAKPIFLHNQLPPPDYPaascPTIET-APAASPVLEPRIPDKIIDADNDD 209
PRK11901 PRK11901
hypothetical protein; Reviewed
 596-735 1.19e-04

hypothetical protein; Reviewed


Pssm-ID: 237015 [Multi-domain]  Cd Length: 327  Bit Score: 45.06  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 596 TGDSGAPPVPPTGDSGAPPVPPTGDSGAPpvpptGDSGAPPVPPTGDSGAPPVPPTGD--------------------SG 655
Cdd:PRK11901   88 SSGNQSSPSAANNTSDGHDASGVKNTAPP-----QDISAPPISPTPTQAAPPQTPNGQqrielpgnisdalsqqqgqvNA 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 656 APPVPPTGDSGAPP----VPPTGDAGPPPVPPTgdsgaPPVPPTGDSGAPPVTPTGDSETAPVPPTG-DSGAPPVPPTGD 730
Cdd:PRK11901  163 ASQNAQGNTSTLPTapatVAPSKGAKVPATAET-----HPTPPQKPATKKPAVNHHKTATVAVPPATsGKPKSGAASARA 237


                  ....*
gi 1547055316 731 SEAAP 735
Cdd:PRK11901  238 LSSAP 242
PHA03201 PHA03201
uracil DNA glycosylase; Provisional
 617-705 1.25e-04

uracil DNA glycosylase; Provisional


Pssm-ID: 165468  Cd Length: 318  Bit Score: 44.88  E-value: 1.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 617 PTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGdaGPPPVppTGDSGAPPVPPTG 696
Cdd:PHA03201    4 ARSRSPSPPRRPSPPRPTPPRSPDASPEETPPSPPGPGAEPPPGRAAGPAAPRRRPRG--CPAGV--TFSSSAPPRPPLG 79


                  ....*....
gi 1547055316 697 DSGAPPVTP 705
Cdd:PHA03201   80 LDDAPAATP 88
half-pint TIGR01645
poly-U binding splicing factor, half-pint family; The proteins represented by this model ...
 575-734 1.42e-04

poly-U binding splicing factor, half-pint family; The proteins represented by this model contain three RNA recognition motifs (rrm: pfam00076) and have been characterized as poly-pyrimidine tract binding proteins associated with RNA splicing factors. In the case of PUF60 (GP|6176532), in complex with p54, and in the presence of U2AF, facilitates association of U2 snRNP with pre-mRNA.


Pssm-ID: 130706 [Multi-domain]  Cd Length: 612  Bit Score: 45.06  E-value: 1.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 575 GDSETAPVP---PTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPtGDSGAPPVPPTG----DSGAPPVPPTGDSGAPP 647
Cdd:TIGR01645 279 GKCVTPPDAllqPATVSAIPAAAAVAAAAATAKIMAAEAVAGAAVL-GPRAQSPATPSSslptDIGNKAVVSSAKKEAEE 357

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 648 VPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGdSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPP 727
Cdd:TIGR01645 358 VPPLPQAAPAVVKPGPMEIPTPVPPPGLAIPSLVAPPG-LVAPTEINPSFLASPRKKMKREKLPVTFGALDDTLAWKEPS 436


                  ....*..
gi 1547055316 728 TGDSEAA 734
Cdd:TIGR01645 437 KEDQTSE 443
PRK14954 PRK14954
DNA polymerase III subunits gamma and tau; Provisional
 594-688 1.44e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184918 [Multi-domain]  Cd Length: 620  Bit Score: 45.32  E-value: 1.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 594 PPTGDSGAPPVPPTGDSGAPPVPP-TGDSGAPPVPPTGDSGAPPVPPTGDSGAPPvpptgdSGAPPVPPTgdsgaPPVPP 672
Cdd:PRK14954  376 NDGGVAPSPAGSPDVKKKAPEPDLpQPDRHPGPAKPEAPGARPAELPSPASAPTP------EQQPPVARS-----APLPP 444

                          90
                  ....*....|....*.
gi 1547055316 673 TGDAGPPPVPPTGDSG 688
Cdd:PRK14954  445 SPQASAPRNVASGKPG 460
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 614-691 1.45e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 45.27  E-value: 1.45e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1547055316  614 PVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPP 691
Cdd:PRK12270    38 PGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAAVED 115
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 607-694 1.68e-04

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 44.99  E-value: 1.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 607 TGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPvpptGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGD 686
Cdd:NF041121   15 MGRAAAPPSPEGPAPTAASQPATPPPPAAPPSPPGDPPEPP----APEPAPLPAPYPGSLAPPPPPPPGPAGAAPGAALP 90


                  ....*...
gi 1547055316 687 SGAPPVPP 694
Cdd:NF041121   91 VRVPAPPA 98
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 664-746 1.69e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 45.27  E-value: 1.69e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  664 DSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTgdsETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSK 743
Cdd:PRK12270    37 GPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAA---PAAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAAV 113


                   ...
gi 1547055316  744 EAQ 746
Cdd:PRK12270   114 EDE 116
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 565-647 1.75e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 45.27  E-value: 1.75e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  565 DSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPtgdsGAPPVPPTGDSGAPPVPPTGDSG 644
Cdd:PRK12270    37 GPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAA----AAAAAAPAAPPAAAAAAAPAAAA 112


                   ...
gi 1547055316  645 APP 647
Cdd:PRK12270   113 VED 115
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 560-636 1.85e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 45.27  E-value: 1.85e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1547055316  560 VPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPT-GDSGAPPVPPTGDSGAPPVPPTGDSGAPP 636
Cdd:PRK12270    38 PGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKpAAAAAAAAAPAAPPAAAAAAAPAAAAVED 115
PRK10856 PRK10856
cytoskeleton protein RodZ;
567-667 1.91e-04

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 44.25  E-value: 1.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 567 EATPVPpTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPtgdSGAPPVPPTGDSGAPPVPPTGDSGAPPVP-PTGDSGA 645
Cdd:PRK10856  158 SGQSVP-LDTSTTTDPATTPAPAAPVDTTPTNSQTPAVAT---APAPAVDPQQNAVVAPSQANVDTAATPAPaAPATPDG 233

                          90       100
                  ....*....|....*....|..
gi 1547055316 646 PPVPPTGDsgAPPVPPTGDSGA 667
Cdd:PRK10856  234 AAPLPTDQ--AGVSTPAADPNA 253
DamX COG3266
Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell ...
 630-735 2.13e-04

Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442497 [Multi-domain]  Cd Length: 455  Bit Score: 44.46  E-value: 2.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 630 GDSGAPPVPPTGDSGAPPVPPTGDsGAPPVPPTG---DSGAPPVPPTGDAGPPPVPPTgdsgaPPVPPTgdsgAPPVTPT 706
Cdd:COG3266   262 SSASAPATTSLGEQQEVSLPPAVA-AQPAAAAAAqpsAVALPAAPAAAAAAAAPAEAA-----APQPTA----AKPVVTE 331

                          90       100
                  ....*....|....*....|....*....
gi 1547055316 707 GDSETAPVPPTGDSGAPPVPPTGDSEAAP 735
Cdd:COG3266   332 TAAPAAPAPEAAAAAAAPAAPAVAKKLAA 360
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 642-724 2.16e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 44.88  E-value: 2.16e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  642 DSGAPPVPPTGDSGAPPVPPtgdsgAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVT-PTGDSETAPVPPTGDS 720
Cdd:PRK12270    37 GPGSTAAPTAAAAAAAAAAS-----APAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAaPAAPPAAAAAAAPAAA 111


                   ....
gi 1547055316  721 GAPP 724
Cdd:PRK12270   112 AVED 115
PRK12495 PRK12495
hypothetical protein; Provisional
 574-677 2.19e-04

hypothetical protein; Provisional


Pssm-ID: 183558 [Multi-domain]  Cd Length: 226  Bit Score: 43.32  E-value: 2.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 574 TGDSETAPVPptGDSGAPPVPPTgDSGAPPVPPTGDSGAPPVPPTGD-SGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTG 652
Cdd:PRK12495   78 AGDGAEATAP--SDAGSQASPDD-DAQPAAEAEAADQSAPPEASSTSaTDEAATDPPATAAARDGPTPDPTAQPATPDER 154

                          90       100
                  ....*....|....*....|....*
gi 1547055316 653 DSGAPPVPPTGDSGAPPVPPTGDAG 677
Cdd:PRK12495  155 RSPRQRPPVSGEPPTPSTPDAHVAG 179
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 603-680 2.23e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 44.88  E-value: 2.23e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1547055316  603 PVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPP 680
Cdd:PRK12270    38 PGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAAVED 115
PRK14949 PRK14949
DNA polymerase III subunits gamma and tau; Provisional
 613-749 2.24e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237863 [Multi-domain]  Cd Length: 944  Bit Score: 44.72  E-value: 2.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 613 PPVPPtgdSGAPPVPPTGDSGAPPVPPTGDSGAPPVP--PTGDSGAPPVPPTGDSGAPPVPPTGDAGPPP--VPPTGDSG 688
Cdd:PRK14949  645 PKTPP---SRAPPASLSKPASSPDASQTSASFDLDPDfeLATHQSVPEAALASGSAPAPPPVPDPYDRPPweEAPEVASA 721

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1547055316 689 A-PPVPPTGDSGAPPVTPTGDSETAPVPPTgdSGAPP-VPPTGDSEAAPVPPTDDSKEAQMPA 749
Cdd:PRK14949  722 NdGPNNAAEGNLSESVEDASNSELQAVEQQ--ATHQPqVQAEAQSPASTTALTQTSSEVQDTE 782
PHA03247 PHA03247
large tegument protein UL36; Provisional
 545-642 2.34e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 2.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  545 TYLALPTVTDQEATPVPPTGDSEATPVPPTGdseTAPVPPTGDsGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTG---DS 621
Cdd:PHA03247   393 TPFARGPGGDDQTRPAAPVPASVPTPAPTPV---PASAPPPPA-TPLPSAEPGSDDGPAPPPERQPPAPATEPAPddpDD 468

                           90       100
                   ....*....|....*....|.
gi 1547055316  622 GAPPVPPTGDSGAPPVPPTGD 642
Cdd:PHA03247   469 ATRKALDALRERRPPEPPGAD 489
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 593-683 2.41e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 44.88  E-value: 2.41e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  593 VPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPtgdsgAPPVPPTgdsgAPPVPP 672
Cdd:PRK12270    38 PGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAA-----PAAPPAA----AAAAAP 108

                           90
                   ....*....|.
gi 1547055316  673 TGDAGPPPVPP 683
Cdd:PRK12270   109 AAAAVEDEVTP 119
PRK12727 PRK12727
flagellar biosynthesis protein FlhF;
562-715 2.44e-04

flagellar biosynthesis protein FlhF;


Pssm-ID: 237182 [Multi-domain]  Cd Length: 559  Bit Score: 44.60  E-value: 2.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 562 PTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTG 641
Cdd:PRK12727  117 PVSVPRQAPAAAPVRAASIPSPAAQALAHAAAVRTAPRQEHALSAVPEQLFADFLTTAPVPRAPVQAPVVAAPAPVPAIA 196

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1547055316 642 DSGAPPVPPTGDSGAPPVPPTGDSGAPPvpptgdagPPPVPPtgdsgaPPVPPTGDSGAPPVTPTGDSETAPVP 715
Cdd:PRK12727  197 AALAAHAAYAQDDDEQLDDDGFDLDDAL--------PQILPP------AALPPIVVAPAAPAALAAVAAAAPAP 256
SOBP pfam15279
Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual ...
 561-727 2.47e-04

Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual disability. It carries a zinc-finger of the zf-C2H2 type at the N-terminus, and a highly characteriztic C-terminal PhPhPhPhPhPh motif. The deduced 873-amino acid protein contains an N-terminal nuclear localization signal (NLS), followed by 2 FCS-type zinc finger motifs, a proline-rich region (PR1), a putative RNA-binding motif region, and a C-terminal NLS embedded in a second proline-rich motif. SOBP is expressed in various human tissues, including developing mouse brain at embryonic day 14. In postnatal and adult mouse brain SOBP is expressed in all neurons, with intense staining in the limbic system. Highest expression is in layer V cortical neurons, hippocampus, pyriform cortex, dorsomedial nucleus of thalamus, amygdala, and hypothalamus. Postnatal expression of SOBP in the limbic system corresponds to a time of active synaptogenesis. the family is also referred to as Jackson circler, JXC1. In seven affected siblings from a consanguineous Israeli Arab family with mental retardation, anterior maxillary protrusion, and strabismus mutations were found in this protein.


Pssm-ID: 464609 [Multi-domain]  Cd Length: 325  Bit Score: 44.03  E-value: 2.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 561 PPTGDSEATPVPPTGDSET--APVPPTGDSG--APPVPPTGDSGAPPV--PPTGDSGAPPV---------PPTGDSGAPP 625
Cdd:pfam15279 106 SPTSSNSSKPLISVASSSKllAPKPHEPPSLppPPLPPKKGRRHRPGLhpPLGRPPGSPPMsmtprgllgKPQQHPPPSP 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 626 VPPTGDSGAPPVPPTgdSGAPPVPPTGDSGAPPVPPTgdSGAPPVPPtGDAGPPPVPPTGDSGAP-PVPPTGDSGAPPVT 704
Cdd:pfam15279 186 LPAFMEPSSMPPPFL--RPPPSIPQPNSPLSNPMLPG--IGPPPKPP-RNLGPPSNPMHRPPFSPhHPPPPPTPPGPPPG 260

                         170       180
                  ....*....|....*....|...
gi 1547055316 705 PTGDSETAPVPPTGdsgaPPVPP 727
Cdd:pfam15279 261 LPPPPPRGFTPPFG----PPFPP 279
PHA03201 PHA03201
uracil DNA glycosylase; Provisional
 569-653 2.48e-04

uracil DNA glycosylase; Provisional


Pssm-ID: 165468  Cd Length: 318  Bit Score: 43.73  E-value: 2.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 569 TPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPvPPTGDSGAPPVPPTGDSGAP-P 647
Cdd:PHA03201    8 SPSPPRRPSPPRPTPPRSPDASPEETPPSPPGPGAEPPPGRAAGPAAPRRRPRGCPA-GVTFSSSAPPRPPLGLDDAPaA 86


                  ....*.
gi 1547055316 648 VPPTGD 653
Cdd:PHA03201   87 TPPPLD 92
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 626-711 2.58e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 44.50  E-value: 2.58e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  626 VPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPtgdsgAPPVPPTGDSGAPPVTP 705
Cdd:PRK12270    38 PGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAA-----PAAPPAAAAAAAPAAAA 112


                   ....*.
gi 1547055316  706 TGDSET 711
Cdd:PRK12270   113 VEDEVT 118
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 653-735 2.58e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 44.50  E-value: 2.58e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  653 DSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSE 732
Cdd:PRK12270    37 GPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAAVEDE 116


                   ...
gi 1547055316  733 AAP 735
Cdd:PRK12270   117 VTP 119
FAP pfam07174
Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment ...
 601-702 2.79e-04

Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment proteins (FAP). Family members are rich in alanine and proline, are approximately 300 long, and seem to be restricted to mycobacteria. These proteins contain a fibronectin-binding motif that allows mycobacteria to bind to fibronectin in the extracellular matrix.


Pssm-ID: 429334  Cd Length: 301  Bit Score: 43.76  E-value: 2.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 601 APPVPPTgdSGAPPVPPtgdsgaPPVPPTGDSGAPPVPPTGDSGAPPvPPTGDSGAPPvpptgdsgAPPVPPTGDAGPPP 680
Cdd:pfam07174  44 APPPPST--ATAPPAPP------PPPPAPAAPAPPPPPAAPNAPNAP-PPPADPNAPP--------PPPADPNAPPPPAV 106

                          90       100
                  ....*....|....*....|..
gi 1547055316 681 VPPTGDSGAPPVPPTGDSGAPP 702
Cdd:pfam07174 107 DPNAPEPGRIDNAVGGFSYVVP 128
PRK10856 PRK10856
cytoskeleton protein RodZ;
639-733 2.92e-04

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 43.86  E-value: 2.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 639 PTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPtgdAGPPPVPPTGDSGAPPVPPTGDSGAPPV-TPTGDSETAPVPPT 717
Cdd:PRK10856  163 PLDTSTTTDPATTPAPAAPVDTTPTNSQTPAVAT---APAPAVDPQQNAVVAPSQANVDTAATPApAAPATPDGAAPLPT 239

                          90
                  ....*....|....*.
gi 1547055316 718 GDsgAPPVPPTGDSEA 733
Cdd:PRK10856  240 DQ--AGVSTPAADPNA 253
MISS pfam15822
MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic ...
 584-726 2.96e-04

MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic MAPK-interacting and spindle-stabilising protein-like proteins. MISS is rich in prolines and has four potential MAPK-phosphorylation sites, a MAPK-docking site, a PEST sequence (PEST motif) and a bipartite nuclear localization signal. The endogenous protein accumulates during mouse meiotic maturation and is found as discrete dots on the MII spindle. MISS is the first example of a physiological MAPK-substrate that is stabilized in MII that specifically regulates MII spindle integrity during the CSF arrest.


Pssm-ID: 318115 [Multi-domain]  Cd Length: 238  Bit Score: 43.05  E-value: 2.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 584 PTGDSGAPPVPPTGdsgappVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVP--PTGDSGAPPVPPTGDSGAPPVPP 661
Cdd:pfam15822  35 PWNNPSAPPAVPSG------LPPSTAPSTVPFGPAPTGMYPSIPLTGPSPGPPAPfpPSGPSCPPPGGPYPAPTVPGPGP 108

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1547055316 662 TGDSGAPPVP----------PTGDAGPPPVPPTGDSGAPPVPPT--GDSGAPPVT-PTGDSETAPVPPTGDSGAPPVP 726
Cdd:pfam15822 109 IGPYPTPNMPfpelprpygaPTDPAAAAPSGPWGSMSSGPWAPGmgGQYPAPNMPyPSPGPYPAVPPPQSPGAAPPVP 186
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 604-690 2.96e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 44.50  E-value: 2.96e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  604 VPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPtgdsgAPPVPPTGDAGPPPVPP 683
Cdd:PRK12270    38 PGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAA-----PAAPPAAAAAAAPAAAA 112


                   ....*..
gi 1547055316  684 TGDSGAP 690
Cdd:PRK12270   113 VEDEVTP 119
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 550-706 3.13e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.39  E-value: 3.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  550 PTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSG----APPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPP 625
Cdd:PHA03307   790 VRAEAAFRRPGRLRRSGPAADAASRTASKRKSRSHTPDGGsessGPARPPGAAARPPPARSSESSKSKPAAAGGRARGKN 869

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  626 vpptGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTgdsGAPPVPPTGDAGP-PPVPPTGDSGAPPVPPtGDSGAPPVT 704
Cdd:PHA03307   870 ----GRRRPRPPEPRARPGAAAPPKAAAAAPPAGAPA---PRPRPAPRVKLGPmPPGGPDPRGGFRRVPP-GDLHTPAPS 941


                   ..
gi 1547055316  705 PT 706
Cdd:PHA03307   942 AA 943
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 589-682 3.15e-04

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 43.84  E-value: 3.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 589 GAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPvpptGDSGAP 668
Cdd:NF041121   16 GRAAAPPSPEGPAPTAASQPATPPPPAAPPSPPGDPPEPPAPEPAPLPAPYPGSLAPPPPPPPGPAGAAP----GAALPV 91

                          90
                  ....*....|....
gi 1547055316 669 PVPptgdaGPPPVP 682
Cdd:NF041121   92 RVP-----APPALP 100
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 578-673 3.29e-04

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 43.84  E-value: 3.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 578 ETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPvpptGDSGAP 657
Cdd:NF041121   16 GRAAAPPSPEGPAPTAASQPATPPPPAAPPSPPGDPPEPPAPEPAPLPAPYPGSLAPPPPPPPGPAGAAP----GAALPV 91

                          90
                  ....*....|....*.
gi 1547055316 658 PVPptgdsgAPPVPPT 673
Cdd:NF041121   92 RVP------APPALPN 101
PRK10856 PRK10856
cytoskeleton protein RodZ;
606-708 3.30e-04

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 43.48  E-value: 3.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 606 PTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPtgdSGAPPVPPTGDSGAPPVPPTGDSGAPPVP-PTGDAGPPPVPPT 684
Cdd:PRK10856  163 PLDTSTTTDPATTPAPAAPVDTTPTNSQTPAVAT---APAPAVDPQQNAVVAPSQANVDTAATPAPaAPATPDGAAPLPT 239

                          90       100
                  ....*....|....*....|....
gi 1547055316 685 GDsgAPPVPPTGDSGAPPVTPTGD 708
Cdd:PRK10856  240 DQ--AGVSTPAADPNALVMNFTAD 261
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 644-727 3.34e-04

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 43.84  E-value: 3.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 644 GAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPtGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAP 723
Cdd:NF041121   16 GRAAAPPSPEGPAPTAASQPATPPPPAAPPSPPGDPPEPP-APEPAPLPAPYPGSLAPPPPPPPGPAGAAPGAALPVRVP 94


                  ....
gi 1547055316 724 PVPP 727
Cdd:NF041121   95 APPA 98
PRK10856 PRK10856
cytoskeleton protein RodZ;
584-689 3.36e-04

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 43.48  E-value: 3.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 584 PTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPtgdSGAPPVPPTGDSGAPPVPPTGDSGAPPVPptgdsgappvPPTG 663
Cdd:PRK10856  163 PLDTSTTTDPATTPAPAAPVDTTPTNSQTPAVAT---APAPAVDPQQNAVVAPSQANVDTAATPAP----------AAPA 229

                          90       100
                  ....*....|....*....|....*.
gi 1547055316 664 DSGAPPVPPTGDAGppPVPPTGDSGA 689
Cdd:PRK10856  230 TPDGAAPLPTDQAG--VSTPAADPNA 253
Gag_spuma pfam03276
Spumavirus gag protein;
617-738 3.40e-04

Spumavirus gag protein;


Pssm-ID: 460872 [Multi-domain]  Cd Length: 614  Bit Score: 43.97  E-value: 3.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 617 PTGDSGAPPVppTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPvPPTGDAGPPPVPPTGDSG-----APP 691
Cdd:pfam03276 180 PGAQGGIPPG--ASFSGLPSLPAIGGIHLPAIPGIHARAPPGNIARSLGDDIM-PSLGDAGMPQPRFAFHPGnpfaeAEG 256

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1547055316 692 VPPTGDSG----APPVTPTGDSETAPVPPTGDSGAPPVPPtgdSEAAPVPP 738
Cdd:pfam03276 257 HPFAEAEGerprDIPRAPRIDAPSAPAIPAIQPIAPPMIP---PIGAPIPI 304
Med25_SD1 pfam11235
Mediator complex subunit 25 synapsin 1; The overall function of the full-length Med25 is ...
 571-724 3.57e-04

Mediator complex subunit 25 synapsin 1; The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA, domain, this SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This The function of the SD domains is unclear.


Pssm-ID: 463244 [Multi-domain]  Cd Length: 157  Bit Score: 41.69  E-value: 3.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 571 VPPTGDSETAPVPPTGDSGAPPVPPTGD--SGAPPVPptgdsgAPPVPPT----GDSGAPPVPPTGDSGAPPVPPTG-DS 643
Cdd:pfam11235   1 LPVGGGSAPGPLQSKQPVPLPPAAPSGAtlSAAPQQP------LPPVPPQyqvpGNLSAAQVAAQNAVEAAKNQKAGlGP 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 644 GAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAP 723
Cdd:pfam11235  75 RFSPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPVPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPS 154


                  .
gi 1547055316 724 P 724
Cdd:pfam11235 155 P 155
PHA03418 PHA03418
hypothetical E4 protein; Provisional
 562-698 3.58e-04

hypothetical E4 protein; Provisional


Pssm-ID: 177646 [Multi-domain]  Cd Length: 230  Bit Score: 42.80  E-value: 3.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 562 PTGDSEATPVPPTgDSETAPVPPTGDSG--APPVPPT----GDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAP 635
Cdd:PHA03418   44 PQEDPDKNPSPPP-DPPLTPRPPAQPNGhnKPPVTKQpggeGTEEDHQAPLAADADDDPRPGKRSKADEHGPAPGRAALA 122

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1547055316 636 PV-------PPTGDsgaPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAG----PPPVPPTGDsgapPVPPTGDS 698
Cdd:PHA03418  123 PFkldldqdPLHGD---PDPPPGATGGQGEEPPEGGEESQPPLGEGEGAveghPPPLPPAPE----PKPHNGDA 189
PHA03201 PHA03201
uracil DNA glycosylase; Provisional
 580-664 3.59e-04

uracil DNA glycosylase; Provisional


Pssm-ID: 165468  Cd Length: 318  Bit Score: 43.34  E-value: 3.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 580 APVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPvPPTGDSGAPPVPPTGDSGAP-P 658
Cdd:PHA03201    8 SPSPPRRPSPPRPTPPRSPDASPEETPPSPPGPGAEPPPGRAAGPAAPRRRPRGCPA-GVTFSSSAPPRPPLGLDDAPaA 86


                  ....*.
gi 1547055316 659 VPPTGD 664
Cdd:PHA03201   87 TPPPLD 92
PHA03418 PHA03418
hypothetical E4 protein; Provisional
 581-731 3.64e-04

hypothetical E4 protein; Provisional


Pssm-ID: 177646 [Multi-domain]  Cd Length: 230  Bit Score: 42.80  E-value: 3.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 581 PVPPTGDSGAPPVPPTGDSGAPPVPPTgdSGAPPVPPTGDSgAPPVPPT----GDSGAPPVPPTGDSGAPPVPPTGDSGA 656
Cdd:PHA03418   34 PLLPAPHHPNPQEDPDKNPSPPPDPPL--TPRPPAQPNGHN-KPPVTKQpggeGTEEDHQAPLAADADDDPRPGKRSKAD 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 657 PPVPPTGDSGAPPV-------PPTGDAGPPPvPPTGDSGAppVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTG 729
Cdd:PHA03418  111 EHGPAPGRAALAPFkldldqdPLHGDPDPPP-GATGGQGE--EPPEGGEESQPPLGEGEGAVEGHPPPLPPAPEPKPHNG 187


                  ..
gi 1547055316 730 DS 731
Cdd:PHA03418  188 DA 189
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 640-738 3.71e-04

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 43.84  E-value: 3.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 640 TGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPvPPTGDSGAPPVPPtgdsgappvtptgdsETAPVPPTGD 719
Cdd:NF041121   15 MGRAAAPPSPEGPAPTAASQPATPPPPAAPPSPPGDPPEPP-APEPAPLPAPYPG---------------SLAPPPPPPP 78

                          90
                  ....*....|....*....
gi 1547055316 720 SGAPPVPPTGDSEAAPVPP 738
Cdd:NF041121   79 GPAGAAPGAALPVRVPAPP 97
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 581-658 3.72e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 44.11  E-value: 3.72e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1547055316  581 PVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPP 658
Cdd:PRK12270    38 PGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAAVED 115
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 592-669 3.72e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 44.11  E-value: 3.72e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1547055316  592 PVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPP 669
Cdd:PRK12270    38 PGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAAVED 115
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 550-728 3.73e-04

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 43.76  E-value: 3.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 550 PTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTG-DSGAPPVPPTgdsgapPVPPTGDSGAPPVPP 628
Cdd:PLN03209  396 ASSKSVDAVAKPAEPDVVPSPGSASNVPEVEPAQVEAKKTRPLSPYARyEDLKPPTSPS------PTAPTGVSPSVSSTS 469

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 629 TGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSgAPPVPPTGDAGPPPVPPtgdSGAPPVPPTGDSGAPPVTPTGD 708
Cdd:PLN03209  470 SVPAVPDTAPATAATDAAAPPPANMRPLSPYAVYDDL-KPPTSPSPAAPVGKVAP---SSTNEVVKVGNSAPPTALADEQ 545

                         170       180
                  ....*....|....*....|....*.
gi 1547055316 709 SETAPVP------PTGDSGAPPVPPT 728
Cdd:PLN03209  546 HHAQPKPrplspyTMYEDLKPPTSPT 571
PHA03169 PHA03169
hypothetical protein; Provisional
 608-744 3.82e-04

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 43.42  E-value: 3.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 608 GDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGaPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPpvppTGDS 687
Cdd:PHA03169  100 VGSPTPSPSGSAEELASGLSPENTSGSSPESPASHSP-PPSPPSHPGPHEPAPPESHNPSPNQQPSSFLQPS----HEDS 174

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 688 GAPPVPPTGDsgAPPVTP-TGDSETA-PVPPTGDSGAPPVPPTGDS-EAAPVPPTDDSKE 744
Cdd:PHA03169  175 PEEPEPPTSE--PEPDSPgPPQSETPtSSPPPQSPPDEPGEPQSPTpQQAPSPNTQQAVE 232
FAP pfam07174
Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment ...
 557-652 3.88e-04

Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment proteins (FAP). Family members are rich in alanine and proline, are approximately 300 long, and seem to be restricted to mycobacteria. These proteins contain a fibronectin-binding motif that allows mycobacteria to bind to fibronectin in the extracellular matrix.


Pssm-ID: 429334  Cd Length: 301  Bit Score: 43.38  E-value: 3.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 557 ATPVPPTGDSEATPVPPTgDSETAPVPPTgdsgAPPVPptgdsGAP-PVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAP 635
Cdd:pfam07174  32 ALPAVAHADPEPAPPPPS-TATAPPAPPP----PPPAP-----AAPaPPPPPAAPNAPNAPPPPADPNAPPPPPADPNAP 101

                          90
                  ....*....|....*..
gi 1547055316 636 PVPPTgdsgAPPVPPTG 652
Cdd:pfam07174 102 PPPAV----DPNAPEPG 114
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 549-682 3.94e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.99  E-value: 3.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 549 LPTVTDQEATPVPPTGDSEATPVPPTGDSETapvPPTGDSGAPPVPPTgdsgapPVPPTGDSGAPPVPPTgdSGAPPVPP 628
Cdd:pfam03154 418 MPQSQQLPPPPAQPPVLTQSQSLPPPAASHP---PTSGLHQVPSQSPF------PQHPFVPGGPPPITPP--SGPPTSTS 486

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1547055316 629 TGDSGAPPVPPTGDSGAPPVPPTGDSGAPPV----PPTGDSGAPPVPPTGDAGPPPVP 682
Cdd:pfam03154 487 SAMPGIQPPSSASVSSSGPVPAAVSCPLPPVqikeEALDEAEEPESPPPPPRSPSPEP 544
SOBP pfam15279
Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual ...
 583-716 4.08e-04

Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual disability. It carries a zinc-finger of the zf-C2H2 type at the N-terminus, and a highly characteriztic C-terminal PhPhPhPhPhPh motif. The deduced 873-amino acid protein contains an N-terminal nuclear localization signal (NLS), followed by 2 FCS-type zinc finger motifs, a proline-rich region (PR1), a putative RNA-binding motif region, and a C-terminal NLS embedded in a second proline-rich motif. SOBP is expressed in various human tissues, including developing mouse brain at embryonic day 14. In postnatal and adult mouse brain SOBP is expressed in all neurons, with intense staining in the limbic system. Highest expression is in layer V cortical neurons, hippocampus, pyriform cortex, dorsomedial nucleus of thalamus, amygdala, and hypothalamus. Postnatal expression of SOBP in the limbic system corresponds to a time of active synaptogenesis. the family is also referred to as Jackson circler, JXC1. In seven affected siblings from a consanguineous Israeli Arab family with mental retardation, anterior maxillary protrusion, and strabismus mutations were found in this protein.


Pssm-ID: 464609 [Multi-domain]  Cd Length: 325  Bit Score: 43.26  E-value: 4.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 583 PPTGDSGAPPVPPTGDSGAPPVPPTgdSGAPPVPPTGDSGAPPVPPTgdSGAPPVPPtGDSGAPPV----PPTGDSGAPP 658
Cdd:pfam15279 176 KPQQHPPPSPLPAFMEPSSMPPPFL--RPPPSIPQPNSPLSNPMLPG--IGPPPKPP-RNLGPPSNpmhrPPFSPHHPPP 250

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1547055316 659 VPPtgdsgaPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPP 716
Cdd:pfam15279 251 PPT------PPGPPPGLPPPPPRGFTPPFGPPFPPVNMMPNPPEMNFGLPSLAPLVPP 302
PRK12495 PRK12495
hypothetical protein; Provisional
 552-655 4.22e-04

hypothetical protein; Provisional


Pssm-ID: 183558 [Multi-domain]  Cd Length: 226  Bit Score: 42.55  E-value: 4.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 552 VTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGD-SGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTG 630
Cdd:PRK12495   75 GDDAGDGAEATAPSDAGSQASPDDDAQPAAEAEAADQSAPPEASSTSaTDEAATDPPATAAARDGPTPDPTAQPATPDER 154

                          90       100
                  ....*....|....*....|....*
gi 1547055316 631 DSGAPPVPPTGDSGAPPVPPTGDSG 655
Cdd:PRK12495  155 RSPRQRPPVSGEPPTPSTPDAHVAG 179
PHA03201 PHA03201
uracil DNA glycosylase; Provisional
 614-697 4.24e-04

uracil DNA glycosylase; Provisional


Pssm-ID: 165468  Cd Length: 318  Bit Score: 42.96  E-value: 4.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 614 PVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPvPPTGDAGPPPVPPTGDSGAP-PV 692
Cdd:PHA03201    9 PSPPRRPSPPRPTPPRSPDASPEETPPSPPGPGAEPPPGRAAGPAAPRRRPRGCPA-GVTFSSSAPPRPPLGLDDAPaAT 87


                  ....*
gi 1547055316 693 PPTGD 697
Cdd:PHA03201   88 PPPLD 92
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 467-742 4.34e-04

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 43.41  E-value: 4.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 467 FATPTGYRPQdrtvSKAMIAYWTNFAKTGDPNMGDSAVPTHWEPYTTENSGYLEITKKMGSSSMKRSlrtnflrywTLTy 546
Cdd:pfam17823 142 FSAPRAAACR----ANASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSAPTTAASSAPA---------TLT- 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 547 LALPTVTDQEATPVPPTGDSEA-----TPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVP----P 617
Cdd:pfam17823 208 PARGISTAATATGHPAAGTALAavgnsSPAAGTVTAAVGTVTPAALATLAAAAGTVASAAGTINMGDPHARRLSPakhmP 287

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 618 TGDSGAPPVPPTGDSGAPPV-------PPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGD-------AGPPPVPP 683
Cdd:pfam17823 288 SDTMARNPAAPMGAQAQGPIiqvstdqPVHNTAGEPTPSPSNTTLEPNTPKSVASTNLAVVTTTKaqakepsASPVPVLH 367

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1547055316 684 TgdSGAPPVPPTgdsgappvTPTgdSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDS 742
Cdd:pfam17823 368 T--SMIPEVEAT--------SPT--TQPSPLLPTQGAAGPGILLAPEQVATEATAGTAS 414
PHA03201 PHA03201
uracil DNA glycosylase; Provisional
 647-730 4.36e-04

uracil DNA glycosylase; Provisional


Pssm-ID: 165468  Cd Length: 318  Bit Score: 42.96  E-value: 4.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 647 PVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTpTGDSETAPVPPTGDSGAP-PV 725
Cdd:PHA03201    9 PSPPRRPSPPRPTPPRSPDASPEETPPSPPGPGAEPPPGRAAGPAAPRRRPRGCPAGV-TFSSSAPPRPPLGLDDAPaAT 87


                  ....*
gi 1547055316 726 PPTGD 730
Cdd:PHA03201   88 PPPLD 92
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 571-661 4.37e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 43.73  E-value: 4.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  571 VPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTgdsgappvpPTGDSGAPPVPPTGDSGAPPVPP 650
Cdd:PRK12270    38 PGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPK---------PAAAAAAAAAPAAPPAAAAAAAP 108

                           90
                   ....*....|.
gi 1547055316  651 TGDSGAPPVPP 661
Cdd:PRK12270   109 AAAAVEDEVTP 119
PRK12727 PRK12727
flagellar biosynthesis protein FlhF;
552-693 4.64e-04

flagellar biosynthesis protein FlhF;


Pssm-ID: 237182 [Multi-domain]  Cd Length: 559  Bit Score: 43.44  E-value: 4.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 552 VTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGD 631
Cdd:PRK12727  118 VSVPRQAPAAAPVRAASIPSPAAQALAHAAAVRTAPRQEHALSAVPEQLFADFLTTAPVPRAPVQAPVVAAPAPVPAIAA 197

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1547055316 632 SGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTgdsGAPPVPPTGDAGPPPVPPTGDSGAPPVP 693
Cdd:PRK12727  198 ALAAHAAYAQDDDEQLDDDGFDLDDALPQIL---PPAALPPIVVAPAAPAALAAVAAAAPAP 256
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 648-738 4.84e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 43.73  E-value: 4.84e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  648 VPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPtgdsETAPVPPtgdsgAPPVPP 727
Cdd:PRK12270    38 PGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAA----PAAPPAA-----AAAAAP 108

                           90
                   ....*....|.
gi 1547055316  728 TGDSEAAPVPP 738
Cdd:PRK12270   109 AAAAVEDEVTP 119
PHA03369 PHA03369
capsid maturational protease; Provisional
 566-662 4.95e-04

capsid maturational protease; Provisional


Pssm-ID: 223061 [Multi-domain]  Cd Length: 663  Bit Score: 43.45  E-value: 4.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 566 SEATPVPPTGDSETAPVPPTGdsGAPPVPPTGDSGAPPVPPTGDSGAPPvPPTGDSGAPPVPPTGDSGAPPVPPTGDSGA 645
Cdd:PHA03369  349 KTASLTAPSRVLAAAAKVAVI--AAPQTHTGPADRQRPQRPDGIPYSVP-ARSPMTAYPPVPQFCGDPGLVSPYNPQSPG 425

                          90
                  ....*....|....*..
gi 1547055316 646 PPVPPTGDSGAPPVPPT 662
Cdd:PHA03369  426 TSYGPEPVGPVPPQPTN 442
PHA03264 PHA03264
envelope glycoprotein D; Provisional
 560-662 4.99e-04

envelope glycoprotein D; Provisional


Pssm-ID: 223029 [Multi-domain]  Cd Length: 416  Bit Score: 43.07  E-value: 4.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 560 VPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAP--PVPPTGDSGAPPV 637
Cdd:PHA03264  254 VPPYFEESKGYEPPPAPSGGSPAPPGDDRPEAKPEPGPVEDGAPGRETGGEGEGPEPAGRDGAAGgePKPGPPRPAPDAD 333

                          90       100
                  ....*....|....*....|....*
gi 1547055316 638 PPTGDSGAPPVPPTGDSGAPPVPPT 662
Cdd:PHA03264  334 RPEGWPSLEAITFPPPTPATPAVPR 358
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 637-717 5.27e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 43.73  E-value: 5.27e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  637 VPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTgdSGAPPVPPTGDSGAPPVTPTGDSETAPVPP 716
Cdd:PRK12270    38 PGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPK--PAAAAAAAAAPAAPPAAAAAAAPAAAAVED 115


                   .
gi 1547055316  717 T 717
Cdd:PRK12270   116 E 116
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 563-662 5.61e-04

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 43.07  E-value: 5.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 563 TGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPvpptGDSGAPPVPPTGDSGAPPVPPTGDsgaPPVPPTGD 642
Cdd:NF041121   15 MGRAAAPPSPEGPAPTAASQPATPPPPAAPPSPPGDPPEPP----APEPAPLPAPYPGSLAPPPPPPPG---PAGAAPGA 87

                          90       100
                  ....*....|....*....|
gi 1547055316 643 SGAPPVPptgdsgAPPVPPT 662
Cdd:NF041121   88 ALPVRVP------APPALPN 101
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
548-668 5.62e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.33  E-value: 5.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 548 ALPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPP---VPPTGDSGAP----PVPPTGDSGAPPVPPTGD 620
Cdd:PRK12323  454 PAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPweeLPPEFASPAPaqpdAAPAGWVAESIPDPATAD 533

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1547055316 621 SGAPPVPPTGDSGAPPVPPTGDSGAPPVPPT-GDSGAPPVPPTGDSGAP 668
Cdd:PRK12323  534 PDDAFETLAPAPAAAPAPRAAAATEPVVAPRpPRASASGLPDMFDGDWP 582
PRK10856 PRK10856
cytoskeleton protein RodZ;
628-722 5.63e-04

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 42.71  E-value: 5.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 628 PTGDSGAPPVPPTGDSgAPPVPPTGDSGapPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVP-PTGDSGAPPVTPT 706
Cdd:PRK10856  163 PLDTSTTTDPATTPAP-AAPVDTTPTNS--QTPAVATAPAPAVDPQQNAVVAPSQANVDTAATPAPaAPATPDGAAPLPT 239

                          90
                  ....*....|....*.
gi 1547055316 707 GDseTAPVPPTGDSGA 722
Cdd:PRK10856  240 DQ--AGVSTPAADPNA 253
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 644-748 5.69e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.60  E-value: 5.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 644 GAPPV--PPTGDSGAPPVPPTGDSGAPPVPPTgdAGPPPVPPTGDSGAPPVPPTGDSGAPPVT-----PTGDSETAPVPP 716
Cdd:pfam03154 169 TQPPVlqAQSGAASPPSPPPPGTTQAATAGPT--PSAPSVPPQGSPATSQPPNQTQSTAAPHTliqqtPTLHPQRLPSPH 246

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1547055316 717 TGDSGAPPVPPTGDSEAAPVPPTddSKEAQMP 748
Cdd:pfam03154 247 PPLQPMTQPPPPSQVSPQPLPQP--SLHGQMP 276
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 588-738 5.83e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 43.62  E-value: 5.83e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  588 SGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGA 667
Cdd:PHA03307   762 SLVPAKLAEALALLEPAEPQRGAGSSPPVRAEAAFRRPGRLRRSGPAADAASRTASKRKSRSHTPDGGSESSGPARPPGA 841

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1547055316  668 PPVPPTGDAGPPPVPptgDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPP 738
Cdd:PHA03307   842 AARPPPARSSESSKS---KPAAAGGRARGKNGRRRPRPPEPRARPGAAAPPKAAAAAPPAGAPAPRPRPAP 909
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 639-735 6.12e-04

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 42.54  E-value: 6.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 639 PTGDSGAPPVPPTgdsgAPPVPPTgDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPpvtptgdSETAPVPPTG 718
Cdd:PHA02682   76 PSGQSPLAPSPAC----AAPAPAC-PACAPAAPAPAVTCPAPAPACPPATAPTCPPPAVCPAP-------ARPAPACPPS 143

                          90
                  ....*....|....*..
gi 1547055316 719 DSGAPPVPPTGDSEAAP 735
Cdd:PHA02682  144 TRQCPPAPPLPTPKPAP 160
PRK12727 PRK12727
flagellar biosynthesis protein FlhF;
548-747 6.43e-04

flagellar biosynthesis protein FlhF;


Pssm-ID: 237182 [Multi-domain]  Cd Length: 559  Bit Score: 43.05  E-value: 6.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 548 ALPTV-TDQEATPVPPTGDSEATPVPPTgdSETAPVPPTGDSGAPPVPPTGDSGAPPVP------PTGDSGAPPVPPTGD 620
Cdd:PRK12727   54 ALETArSDTPATAAAPAPAPQAPTKPAA--PVHAPLKLSANANMSQRQRVASAAEDMIAamalrqPVSVPRQAPAAAPVR 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 621 SGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGA 700
Cdd:PRK12727  132 AASIPSPAAQALAHAAAVRTAPRQEHALSAVPEQLFADFLTTAPVPRAPVQAPVVAAPAPVPAIAAALAAHAAYAQDDDE 211

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1547055316 701 PPVTPTGDSETAP---VPPTGDSG---APPVPPTGDSEAAPVP-PTDDSKEAQM 747
Cdd:PRK12727  212 QLDDDGFDLDDALpqiLPPAALPPivvAPAAPAALAAVAAAAPaPQNDEELKQL 265
PHA03201 PHA03201
uracil DNA glycosylase; Provisional
 603-686 6.59e-04

uracil DNA glycosylase; Provisional


Pssm-ID: 165468  Cd Length: 318  Bit Score: 42.57  E-value: 6.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 603 PVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPvPPTGDSGAPPVPPTGDAGPP-PV 681
Cdd:PHA03201    9 PSPPRRPSPPRPTPPRSPDASPEETPPSPPGPGAEPPPGRAAGPAAPRRRPRGCPA-GVTFSSSAPPRPPLGLDDAPaAT 87


                  ....*
gi 1547055316 682 PPTGD 686
Cdd:PHA03201   88 PPPLD 92
NUT pfam12881
NUT protein; This family includes the NUT protein. The gene encoding for NUT protein (Nuclear ...
 568-724 6.91e-04

NUT protein; This family includes the NUT protein. The gene encoding for NUT protein (Nuclear Testis protein) is found fused to BRD3 or BRD4 genes, in some aggressive types of carcinoma, due to chromosomal translocations. Proteins of the BRD family contain two bromodomains that bind transcriptionally active chromatin through associations with acetylated histones H3 and H4. Such proteins are crucial for the regulation of cell cycle progression. On the other hand, little is known about NUT protein. NUT is known to have a Nuclear Export Sequence (NES) as well as a Nuclear localization Signal (NLS), both located towards the C-terminal end of the protein. A fused NUT-GFP protein showed either cytoplasmic or nuclear localization, suggesting that it is subject to nuclear/cytoplasmic shuttling. Consistent with this possibility, treatment with leptomycin B an inhibitor of CRM1-dependent nuclear export resulted in re-distribution of NUT-GFP to the nucleus. Inspection of NUT revealed a C-terminal sequence similar to known nuclear export sequences (NES) which are often regulated by phosphorylation. This family carries some natively unstructured sequence.


Pssm-ID: 432850  Cd Length: 717  Bit Score: 42.92  E-value: 6.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 568 ATPVPPTGDSeTAPVPPTGDSGAPPVPPTGDSGAPPVPPT--------GDSGAPPVPP--------TGDSGAPPVPPTGD 631
Cdd:pfam12881  14 ALPFPPPTPG-PAHQPPWGQPPPPLMTASFPPGSPLVLSAlprtplvaGDGGSGPSGAgacnvivqVRTEGRPVQPPQTQ 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 632 S----GAPPV--PPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAG-----PPPVPPTGDSGAPPVPPtGDSGA 700
Cdd:pfam12881  93 TfvltQAPLNwsAPGALCGGAQCPAPLFLAAPAVETIVPAPAVGGTQAGEGGwipglPPPAPPPAAQLAPIVSP-VNAGP 171

                         170       180
                  ....*....|....*....|....
gi 1547055316 701 PPVTPTGDSetapVPPTGDSGAPP 724
Cdd:pfam12881 172 QPHGASREG----SLATSQAKASP 191
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 549-749 7.17e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 43.14  E-value: 7.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 549 LPTVTDQEATPVPPTG--DSEATPVPPTGDSETAPVPPTgdsgAPPVPPTGD-SGAPPVPPTGDSGAPPVPPTGDSgAPP 625
Cdd:PTZ00449  572 IPTLSKKPEFPKDPKHpkDPEEPKKPKRPRSAQRPTRPK----SPKLPELLDiPKSPKRPESPKSPKRPPPPQRPS-SPE 646

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 626 VPPTGDSGAPPVPPTgdSGAPPVPPT-----GDSGAPPVPPTGDSGAPPVPptgDAGPPPVPPTGDSGAPPVPPTGDSGA 700
Cdd:PTZ00449  647 RPEGPKIIKSPKPPK--SPKPPFDPKfkekfYDDYLDAAAKSKETKTTVVL---DESFESILKETLPETPGTPFTTPRPL 721

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1547055316 701 PPVTPTgdSETAPVPPTGDsgaPPVPPTGDSEAAPVPPTDDSKEAQMPA 749
Cdd:PTZ00449  722 PPKLPR--DEEFPFEPIGD---PDAEQPDDIEFFTPPEEERTFFHETPA 765
PHA03201 PHA03201
uracil DNA glycosylase; Provisional
 584-675 7.32e-04

uracil DNA glycosylase; Provisional


Pssm-ID: 165468  Cd Length: 318  Bit Score: 42.57  E-value: 7.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 584 PTGDSGAPPVPPtgdSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPvPPTGDSGAPPVPPTG 663
Cdd:PHA03201    4 ARSRSPSPPRRP---SPPRPTPPRSPDASPEETPPSPPGPGAEPPPGRAAGPAAPRRRPRGCPA-GVTFSSSAPPRPPLG 79

                          90
                  ....*....|...
gi 1547055316 664 DSGAP-PVPPTGD 675
Cdd:PHA03201   80 LDDAPaATPPPLD 92
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 587-672 7.47e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 42.96  E-value: 7.47e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  587 DSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPvPPTGDSGAPPVPPTGDSGAPPVPPTGDSG 666
Cdd:PRK12270    35 DYGPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPP-KPAAAAAAAAAPAAPPAAAAAAAPAAAAV 113


                   ....*.
gi 1547055316  667 APPVPP 672
Cdd:PRK12270   114 EDEVTP 119
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 582-662 7.60e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 42.96  E-value: 7.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  582 VPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTgdSGAPPVPPTGDSGAPPVPPTGDSGAPPVPP 661
Cdd:PRK12270    38 PGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPK--PAAAAAAAAAPAAPPAAAAAAAPAAAAVED 115


                   .
gi 1547055316  662 T 662
Cdd:PRK12270   116 E 116
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 554-747 7.86e-04

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 42.64  E-value: 7.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 554 DQEATPVPPtgdsEATPVPptgdsetAPVPPTGDSGAPPvpPTGDSGAPPVPPTGdsgaPPVPPTGDSGAPPvPPTGDSG 633
Cdd:PTZ00441  278 EEEECPVEP----EPLPVP-------APVPPTPEDDNPR--PTDDEFAVPNFNEG----LDVPDNPQDPVPP-PNEGKDG 339

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 634 AP---PVPPTGDSGAPPVPPTgdsgaPPVPPTGDSGAPPVPPTGDAGPP-PVPPTGDSGAPPVPPTGDSGAP---PVTPT 706
Cdd:PTZ00441  340 NPneeNLFPPGDDEVPDESNV-----PPNPPNVPGGSNSEFSSDVENPPnPPNPDIPEQEPNIPEDSNKEVPedvPMEPE 414

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1547055316 707 GDSETAPVPPTGDSGappvppTGDSEAAPVPPTDDSKEAQM 747
Cdd:PTZ00441  415 DDRDNNFNEPKKPEN------KGDGQNEPVIPKPLDNERDQ 449
TALPID3 pfam15324
Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for ...
 545-718 8.61e-04

Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.


Pssm-ID: 434634 [Multi-domain]  Cd Length: 1288  Bit Score: 42.95  E-value: 8.61e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  545 TYLALPTVTDQEATP-VPPTGDSEATPVPpTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPpTGDSGA 623
Cdd:pfam15324  982 TLLPTPVPTPQPTPPcSPPSPLKEPSPVK-TPDSSPCVSEHDFFPVKEIPPEKGADTGPAVSLVITPTVTPIA-TPPPAA 1059

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  624 PPVPPTGDSGAPPVPptgdSGAPPVP-PTGDSGAP-----PVPPTGDSGAPPV--------------PPTGDAGPPPVPP 683
Cdd:pfam15324 1060 TPTPPLSENSIDKLK----SPSPELPkPWEDSDLPleeenPNSEQEELHPRAVvmsvardeepesvvLPASPPEPKPLAP 1135

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 1547055316  684 TGDSGAPPVPPTgdsgAPPVTPTGDSETAPVPPTG 718
Cdd:pfam15324 1136 PPLGAAPPSPPQ----SPSSSSSTLESSSSLTVTE 1166
PHA03418 PHA03418
hypothetical E4 protein; Provisional
 554-687 8.79e-04

hypothetical E4 protein; Provisional


Pssm-ID: 177646 [Multi-domain]  Cd Length: 230  Bit Score: 41.65  E-value: 8.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 554 DQEATPVPPTgDSEATPVPPTGDSETAPVPPT------GDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPV- 626
Cdd:PHA03418   47 DPDKNPSPPP-DPPLTPRPPAQPNGHNKPPVTkqpggeGTEEDHQAPLAADADDDPRPGKRSKADEHGPAPGRAALAPFk 125

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1547055316 627 ------PPTGDsgaPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDS 687
Cdd:PHA03418  126 ldldqdPLHGD---PDPPPGATGGQGEEPPEGGEESQPPLGEGEGAVEGHPPPLPPAPEPKPHNGDA 189
DamX COG3266
Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell ...
 548-647 1.03e-03

Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442497 [Multi-domain]  Cd Length: 455  Bit Score: 42.14  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 548 ALPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAP-PVPPTgdsgaPPVPPTgdsgAPPVPPTGDSGAPPV 626
Cdd:COG3266   269 TTSLGEQQEVSLPPAVAAQPAAAAAAQPSAVALPAAPAAAAAAAaPAEAA-----APQPTA----AKPVVTETAAPAAPA 339

                          90       100
                  ....*....|....*....|.
gi 1547055316 627 PPTGDSGAPPVPPTGDSGAPP 647
Cdd:COG3266   340 PEAAAAAAAPAAPAVAKKLAA 360
DamX COG3266
Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell ...
 547-669 1.07e-03

Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442497 [Multi-domain]  Cd Length: 455  Bit Score: 42.14  E-value: 1.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 547 LALPTVTDQEATPVPPTGDSEATPVP-PTGDSETAPVPPTGDsGAPPVPPTGDSGAP--PVPPTGDSGAP-PVPPTgdsg 622
Cdd:COG3266   244 LVLLLLIIGSALKAPSQASSASAPATtSLGEQQEVSLPPAVA-AQPAAAAAAQPSAValPAAPAAAAAAAaPAEAA---- 318

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1547055316 623 aPPVPPTgdsgAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPP 669
Cdd:COG3266   319 -APQPTA----AKPVVTETAAPAAPAPEAAAAAAAPAAPAVAKKLAA 360
PRK12495 PRK12495
hypothetical protein; Provisional
 551-633 1.10e-03

hypothetical protein; Provisional


Pssm-ID: 183558 [Multi-domain]  Cd Length: 226  Bit Score: 41.39  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 551 TVTDQEATPVPPTGDSEATPVPPTGD-SETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPT 629
Cdd:PRK12495   96 PDDDAQPAAEAEAADQSAPPEASSTSaTDEAATDPPATAAARDGPTPDPTAQPATPDERRSPRQRPPVSGEPPTPSTPDA 175


                  ....
gi 1547055316 630 GDSG 633
Cdd:PRK12495  176 HVAG 179
PHA03264 PHA03264
envelope glycoprotein D; Provisional
 648-738 1.11e-03

envelope glycoprotein D; Provisional


Pssm-ID: 223029 [Multi-domain]  Cd Length: 416  Bit Score: 42.30  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 648 VPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPP--VTPTGDSETAPVPPTGDSGAPPV 725
Cdd:PHA03264  254 VPPYFEESKGYEPPPAPSGGSPAPPGDDRPEAKPEPGPVEDGAPGRETGGEGEGPepAGRDGAAGGEPKPGPPRPAPDAD 333

                          90
                  ....*....|....*
gi 1547055316 726 PPTG--DSEAAPVPP 738
Cdd:PHA03264  334 RPEGwpSLEAITFPP 348
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 659-739 1.16e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 42.57  E-value: 1.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  659 VPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTgdSETAPVPPTGDSGAPPVPPTGDSEAAPVPP 738
Cdd:PRK12270    38 PGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPK--PAAAAAAAAAPAAPPAAAAAAAPAAAAVED 115


                   .
gi 1547055316  739 T 739
Cdd:PRK12270   116 E 116
PRK10856 PRK10856
cytoskeleton protein RodZ;
644-736 1.17e-03

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 41.94  E-value: 1.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 644 GAPPVPPTGDSGAPPvpptGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVP--PTGDSG 721
Cdd:PRK10856  158 SGQSVPLDTSTTTDP----ATTPAPAAPVDTTPTNSQTPAVATAPAPAVDPQQNAVVAPSQANVDTAATPAPaaPATPDG 233

                          90
                  ....*....|....*
gi 1547055316 722 APPVPPTGDSEAAPV 736
Cdd:PRK10856  234 AAPLPTDQAGVSTPA 248
PRK14954 PRK14954
DNA polymerase III subunits gamma and tau; Provisional
 642-735 1.18e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184918 [Multi-domain]  Cd Length: 620  Bit Score: 42.24  E-value: 1.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 642 DSGAPPVPPTGdsgappvPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPvtptgdSETAPVPPTgdsg 721
Cdd:PRK14954  377 DGGVAPSPAGS-------PDVKKKAPEPDLPQPDRHPGPAKPEAPGARPAELPSPASAPTP------EQQPPVARS---- 439

                          90
                  ....*....|....
gi 1547055316 722 aPPVPPTGDSEAAP 735
Cdd:PRK14954  440 -APLPPSPQASAPR 452
FAP pfam07174
Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment ...
 543-641 1.25e-03

Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment proteins (FAP). Family members are rich in alanine and proline, are approximately 300 long, and seem to be restricted to mycobacteria. These proteins contain a fibronectin-binding motif that allows mycobacteria to bind to fibronectin in the extracellular matrix.


Pssm-ID: 429334  Cd Length: 301  Bit Score: 41.45  E-value: 1.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 543 TLTYLALPTVT--DQEATPVPPTGDSEATPVPPTGDSETAPVPPtgdsgAPPVPPTGdsgAPPVPPTGDSGAPPVPPTgD 620
Cdd:pfam07174  27 SAVAVALPAVAhaDPEPAPPPPSTATAPPAPPPPPPAPAAPAPP-----PPPAAPNA---PNAPPPPADPNAPPPPPA-D 97

                          90       100
                  ....*....|....*....|.
gi 1547055316 621 SGAPPVPPTgdsgAPPVPPTG 641
Cdd:pfam07174  98 PNAPPPPAV----DPNAPEPG 114
PRK11633 PRK11633
cell division protein DedD; Provisional
 635-740 1.26e-03

cell division protein DedD; Provisional


Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 41.14  E-value: 1.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 635 PPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPvppTGDAGPPPVPPTgdSGAPPVPPTGDSGAPPVTPTGDSETAPV 714
Cdd:PRK11633   42 PLVPKPGDRDEPDMMPAATQALPTQPPEGAAEAVR---AGDAAAPSLDPA--TVAPPNTPVEPEPAPVEPPKPKPVEKPK 116

                          90       100
                  ....*....|....*....|....*.
gi 1547055316 715 PPTGDSGAPPVPPTGDSEAAPVPPTD 740
Cdd:PRK11633  117 PKPKPQQKVEAPPAPKPEPKPVVEEK 142
PHA03419 PHA03419
E4 protein; Provisional
 585-702 1.26e-03

E4 protein; Provisional


Pssm-ID: 223079 [Multi-domain]  Cd Length: 200  Bit Score: 40.70  E-value: 1.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 585 TGDSGAPPVPPTGDSGAPPVPPTGDSGaPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPpvpptGDSGAPPVP---P 661
Cdd:PHA03419   47 TGYPFCPPTTPHPSSQPPPCPPSPGHP-PQTNDTHEKDLALQPPPGGKKKEKKKKETEKPAQ-----GGEKPDQGPeakG 120

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1547055316 662 TGDSGAPPVPPTGDagpPPVPPTGDSGAPPVPPTGDSGAPP 702
Cdd:PHA03419  121 EGEGHEPEDPPPED---TPPPPGGEGEVEGGPSPGPGPGPL 158
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 576-737 1.28e-03

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 41.86  E-value: 1.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 576 DSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPpvpptGDSGAPPVPPTGDSGAPPVPPTGDSGAPP--VPPTGD 653
Cdd:PTZ00436  192 DAAAAAAAKQKAAAKKAAAPSGKKSAKAAAPAKAAAAP-----AKAAAPPAKAAAAPAKAAAAPAKAAAPPAkaAAPPAK 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 654 SGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGApPVPPTGDSGAPPVTPTGDSETApVPPTGDSGAPPVPPTGDSEA 733
Cdd:PTZ00436  267 AAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAAPAKA-AAAPAKAAAAPAKAAAPPAKAA-APPAKAATPPAKAAAPPAKA 344


                  ....
gi 1547055316 734 APVP 737
Cdd:PTZ00436  345 AAAP 348
SAP130_C pfam16014
Histone deacetylase complex subunit SAP130 C-terminus;
606-740 1.31e-03

Histone deacetylase complex subunit SAP130 C-terminus;


Pssm-ID: 464973 [Multi-domain]  Cd Length: 371  Bit Score: 41.84  E-value: 1.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 606 PTGDsGAPPVPPTGDSGAPPVppTGDSGAPPVPpTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPP----- 680
Cdd:pfam16014  15 PATE-GAKPKPDIHVAVAPPV--TVAVEALPGQ-NSEQQTASASPPSQHPAQAIPTILAPAAPPSQPSVVLSTLPaamav 90

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1547055316 681 VPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAP----------------VPPTGDSGAPPVPPTGDSEAApVPPTD 740
Cdd:pfam16014  91 TPPIPASMANVVAPPTQPAASSTAACAVSSVLPeikikqeaepmdtsqsVPPLTPTSISPALTSLANNLS-VPAGD 165
PRK11901 PRK11901
hypothetical protein; Reviewed
 551-707 1.36e-03

hypothetical protein; Reviewed


Pssm-ID: 237015 [Multi-domain]  Cd Length: 327  Bit Score: 41.59  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 551 TVTDQEATPVPPtgdsEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGD--------------------S 610
Cdd:PRK11901   86 SLSSGNQSSPSA----ANNTSDGHDASGVKNTAPPQDISAPPISPTPTQAAPPQTPNGQqrielpgnisdalsqqqgqvN 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 611 GAPPVPPTGDSGAPPVPPTgdsgappVPPTGDSGAPPVPPTgdsgaPPVPPTGDSGAPPVPPTGDAGPPPVPPTgdSGAP 690
Cdd:PRK11901  162 AASQNAQGNTSTLPTAPAT-------VAPSKGAKVPATAET-----HPTPPQKPATKKPAVNHHKTATVAVPPA--TSGK 227

                         170
                  ....*....|....*..
gi 1547055316 691 PVPPTGDSGAPPVTPTG 707
Cdd:PRK11901  228 PKSGAASARALSSAPAS 244
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
630-745 1.44e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 42.07  E-value: 1.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 630 GDSGAPPVPPTgdsgAPPVPPTGDSGAPPVPPTGDSGAPpVPPTGDAGPPPVPPtgdsgaPPVPPTgdSGAPPVTPTGDS 709
Cdd:PRK14971  366 GDDASGGRGPK----QHIKPVFTQPAAAPQPSAAAAASP-SPSQSSAAAQPSAP------QSATQP--AGTPPTVSVDPP 432

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1547055316 710 ETAPVPPTGdSGAPPVPPTGDSEAAPVPPTDDSKEA 745
Cdd:PRK14971  433 AAVPVNPPS-TAPQAVRPAQFKEEKKIPVSKVSSLG 467
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 622-705 1.50e-03

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 41.91  E-value: 1.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 622 GAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPtGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAP 701
Cdd:NF041121   16 GRAAAPPSPEGPAPTAASQPATPPPPAAPPSPPGDPPEPP-APEPAPLPAPYPGSLAPPPPPPPGPAGAAPGAALPVRVP 94


                  ....
gi 1547055316 702 PVTP 705
Cdd:NF041121   95 APPA 98
PHA03132 PHA03132
thymidine kinase; Provisional
 561-728 1.65e-03

thymidine kinase; Provisional


Pssm-ID: 222997 [Multi-domain]  Cd Length: 580  Bit Score: 41.67  E-value: 1.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 561 PPTGDSEATpvpptgDSETAPVPPTGDSGAPPVPPTgdsGAPPVPPTGDSGAPPVP--PTGDSGAPPVPPtgdsGAPPVP 638
Cdd:PHA03132   39 PLGSTSEAT------SEDDDDLYPPRETGSGGGVAT---STIYTVPRPPRGPEQTLdkPDSLPASRELPP----GPTPVP 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 639 PTGDSGAPPVPPTGDSGAPpvPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPptgdsgaPPVTPTGDSETAPVPPTG 718
Cdd:PHA03132  106 PGGFRGASSPRLGADSTSP--RFLYQVNFPVILAPIGESNSSSEELSEEEEHSRP-------PPSESLKVKNGGKVYPKG 176

                         170
                  ....*....|
gi 1547055316 719 DSGAPPVPPT 728
Cdd:PHA03132  177 FSKHKTHKRS 186
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 553-639 1.66e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 42.18  E-value: 1.66e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  553 TDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPvPPTGDSGAPPVPPTGDSGAPPVPPTGDS 632
Cdd:PRK12270    34 ADYGPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPP-KPAAAAAAAAAPAAPPAAAAAAAPAAAA 112


                   ....*..
gi 1547055316  633 GAPPVPP 639
Cdd:PRK12270   113 VEDEVTP 119
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 557-639 1.80e-03

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 41.53  E-value: 1.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 557 ATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPvPPTGDSGAPPVPPTGdsgaPPVPPTGDSGAPPVPPTGDSGAPP 636
Cdd:NF041121   20 APPSPEGPAPTAASQPATPPPPAAPPSPPGDPPEPP-APEPAPLPAPYPGSL----APPPPPPPGPAGAAPGAALPVRVP 94


                  ...
gi 1547055316 637 VPP 639
Cdd:NF041121   95 APP 97
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
608-749 1.84e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 41.68  E-value: 1.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 608 GDSGAPPVPPTgdsgAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTgdsgAPPVPPTgdagPPPVpPTGDS 687
Cdd:PRK14971  366 GDDASGGRGPK----QHIKPVFTQPAAAPQPSAAAAASPSPSQSSAAAQPSAPQS----ATQPAGT----PPTV-SVDPP 432

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1547055316 688 GAPPVPPTGdSGAPPVTPTGDSETAPVPPTGDS--GAPPVPPTGDSEAApvpPTDDSKEAQMPA 749
Cdd:PRK14971  433 AAVPVNPPS-TAPQAVRPAQFKEEKKIPVSKVSslGPSTLRPIQEKAEQ---ATGNIKEAPTGT 492
FAP pfam07174
Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment ...
 669-750 1.85e-03

Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment proteins (FAP). Family members are rich in alanine and proline, are approximately 300 long, and seem to be restricted to mycobacteria. These proteins contain a fibronectin-binding motif that allows mycobacteria to bind to fibronectin in the extracellular matrix.


Pssm-ID: 429334  Cd Length: 301  Bit Score: 41.06  E-value: 1.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 669 PVPPTGDAGPPPvpptgdsgAPPVPPTGDSG-APPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQM 747
Cdd:pfam07174  32 ALPAVAHADPEP--------APPPPSTATAPpAPPPPPPAPAAPAPPPPPAAPNAPNAPPPPADPNAPPPPPADPNAPPP 103


                  ...
gi 1547055316 748 PAV 750
Cdd:pfam07174 104 PAV 106
PRK12438 PRK12438
hypothetical protein; Provisional
 621-679 2.09e-03

hypothetical protein; Provisional


Pssm-ID: 171499 [Multi-domain]  Cd Length: 991  Bit Score: 41.77  E-value: 2.09e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1547055316 621 SGAPPVPPTGDSGAPpvPPTGdsGAPPVPPtgdsgaPPVPPTGDSGAPPVPPTGDAGPP 679
Cdd:PRK12438  899 TGRVATAPGGDAASA--PPPG--AGPPAPP------QAVPPPRTTQPPAAPPRGPDVPP 947
PHA03321 PHA03321
tegument protein VP11/12; Provisional
 588-744 2.10e-03

tegument protein VP11/12; Provisional


Pssm-ID: 223041 [Multi-domain]  Cd Length: 694  Bit Score: 41.48  E-value: 2.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 588 SGAPPVPP-TGDSGAPPVPPTGDSGAPP---VPPTGDSGAPPVPPTGDSGAPPVPPTgdSGAPPVPPTGDSGAPPVPPTG 663
Cdd:PHA03321  427 SRQPPGAPaPRRDNDPPPPPRARPGSTPacaRRARAQRARDAGPEYVDPLGALRRLP--AGAAPPPEPAAAPSPATYYTR 504

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 664 DSGAPPVPPTGDAGPPPVPPtgDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSK 743
Cdd:PHA03321  505 MGGGPPRLPPRNRATETLRP--DWGPPAAAPPEQMEDPYLEPDDDRFDRRDGAAAAATSHPREAPAPDDDPIYEGVSDSE 582


                  .
gi 1547055316 744 E 744
Cdd:PHA03321  583 E 583
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 631-713 2.11e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 41.80  E-value: 2.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  631 DSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPptGDSGAPPVPPTGDSGAPPVTPTGDSE 710
Cdd:PRK12270    35 DYGPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKP--AAAAAAAAAPAAPPAAAAAAAPAAAA 112


                   ...
gi 1547055316  711 TAP 713
Cdd:PRK12270   113 VED 115
KLF1_N cd21581
N-terminal domain of Kruppel-like Factor 1; Kruppel-like Factor 1 (KLF1, also known as ...
 561-707 2.12e-03

N-terminal domain of Kruppel-like Factor 1; Kruppel-like Factor 1 (KLF1, also known as Krueppel-like factor 1 or Erythroid Kruppel-like Factor/EKLF) was the first Kruppel-like factor discovered. It was found to be vitally important for embryonic erythropoiesis in promoting the switch from fetal hemoglobin (Hemoglobin F) to adult hemoglobin (Hemoglobin A) gene expression by binding to highly conserved CACCC domains. EKLF ablation in mouse embryos produces a lethal anemic phenotype, causing death by embryonic day 14, and natural mutations lead to beta+ thalassemia in humans. However, expression of embryonic hemoglobin and fetal hemoglobin genes is normal in EKLF-deficient mice, suggesting other factors may be involved. KLF1 functions as a transcriptional activator. It belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specifity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF1, which is related to the N-terminal domains of KLF2 and KLF4.


Pssm-ID: 409227 [Multi-domain]  Cd Length: 278  Bit Score: 40.80  E-value: 2.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 561 PPTGDSEATPVPPtGDSETAPVPPTGDSGAPPVPPTGDSG---APPVPPTGDSG-APPVPP-------TGDSGAPPVPPT 629
Cdd:cd21581    80 NPSLDNNTQALPQ-EEQPGAYYEPPKKDQPGTEGLQVGGPglmAELLSPEESTGwAPPEPHhgypdafVGPALFPAPANV 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 630 GDSGAPPVPPTGDSGAPPVPPTGDSG-------APPVPPTG-----DSGAPPVPPT-----------GDAGPPP----VP 682
Cdd:cd21581   159 DQFGFPQGGSVDRRGNLSKSGSWDFGsyypqqhPSVVAFPDsrfgpLSGPQALTPDpqhygyfqlfrHNAALFPdyahSP 238

                         170       180
                  ....*....|....*....|....*
gi 1547055316 683 PTGDSGAPPVPPTGDSGAPPVTPTG 707
Cdd:cd21581   239 GPGHLPLGQQPLLPDPPLPPGGAEG 263
flhF PRK06995
flagellar biosynthesis protein FlhF;
576-690 2.21e-03

flagellar biosynthesis protein FlhF;


Pssm-ID: 235904 [Multi-domain]  Cd Length: 484  Bit Score: 41.11  E-value: 2.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 576 DSETAPVPPTGDSGAPPVPPtgdsgaPPVPPTGDSGAPPVPPtGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSG 655
Cdd:PRK06995   45 DSDLAALAPPAAAAPAAAQP------PPAAAPAAVSRPAAPA-AEPAPWLVEHAKRLTAQREQLVARAAAPAAPEAQAPA 117

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1547055316 656 APPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAP 690
Cdd:PRK06995  118 APAERAAAENAARRLARAAAAAPRPRVPADAAAAV 152
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 567-737 2.28e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 41.44  E-value: 2.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 567 EATPVPPTGDSE--TAPVPPTGDSGAPPVPP--TGDSGAPPVPPTGDSGAPpVPPTGDSGAPPVPPTgdsgappvPPTGD 642
Cdd:pfam05109 426 ESTTTSPTLNTTgfAAPNTTTGLPSSTHVPTnlTAPASTGPTVSTADVTSP-TPAGTTSGASPVTPS--------PSPRD 496

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 643 SGAppvpptgDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGApPVTPTGDSeTAPVP----PTG 718
Cdd:pfam05109 497 NGT-------ESKAPDMTSPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSA-VTTPTPNA-TSPTPavttPTP 567

                         170
                  ....*....|....*....
gi 1547055316 719 DSGAPPVPPTGDSEAAPVP 737
Cdd:pfam05109 568 NATIPTLGKTSPTSAVTTP 586
PHA03419 PHA03419
E4 protein; Provisional
 574-682 2.40e-03

E4 protein; Provisional


Pssm-ID: 223079 [Multi-domain]  Cd Length: 200  Bit Score: 39.93  E-value: 2.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 574 TGDSETAPVPPTGDSGAPPVPPTGDSGaPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPpvpptGDSGAPPVP---P 650
Cdd:PHA03419   47 TGYPFCPPTTPHPSSQPPPCPPSPGHP-PQTNDTHEKDLALQPPPGGKKKEKKKKETEKPAQ-----GGEKPDQGPeakG 120

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1547055316 651 TGDSGAPPVPPTGDsgaPPVPPTG----DAGPPPVP 682
Cdd:PHA03419  121 EGEGHEPEDPPPED---TPPPPGGegevEGGPSPGP 153
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 617-716 2.44e-03

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 40.61  E-value: 2.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 617 PTGDSGAPPVPPTG------DSGAPPVP---PTGDSGAPPVPPTGDSGAPP--VPPTGDSGAPPVPPTGDAGPPPVPPTG 685
Cdd:PHA02682   76 PSGQSPLAPSPACAapapacPACAPAAPapaVTCPAPAPACPPATAPTCPPpaVCPAPARPAPACPPSTRQCPPAPPLPT 155

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1547055316 686 DSGAPPVPPT--GDSGAPPVTPTGDSETAPVPP 716
Cdd:PHA02682  156 PKPAPAAKPIflHNQLPPPDYPAASCPTIETAP 188
PRK14965 PRK14965
DNA polymerase III subunits gamma and tau; Provisional
 665-750 2.48e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237871 [Multi-domain]  Cd Length: 576  Bit Score: 41.27  E-value: 2.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 665 SGAPPVPPTGDAGPPPVPPtgdsgAPPvPPTGDSGAPPVTPTGDSETAPVPPtgdsgapPVPPtgdseAAPVPPTDDSKE 744
Cdd:PRK14965  379 RGAPAPPSAAWGAPTPAAP-----AAP-PPAAAPPVPPAAPARPAAARPAPA-------PAPP-----AAAAPPARSADP 440


                  ....*.
gi 1547055316 745 AQMPAV 750
Cdd:PRK14965  441 AAAASA 446
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 548-683 2.63e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 41.00  E-value: 2.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 548 ALPTVTDQEATPVPPTGDSEATPVPPTgdSETAPVPPTGDSGAPPVPPTGDSGAPP--VPPTGDSGAPPVPPTGDSGAPP 625
Cdd:PRK07994  374 SAAPAASAQATAAPTAAVAPPQAPAVP--PPPASAPQQAPAVPLPETTSQLLAARQqlQRAQGATKAKKSEPAAASRARP 451

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 626 VPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAP--PVPPTGDSGAPPVPPTGDAGPPPVPP 683
Cdd:PRK07994  452 VNSALERLASVRPAPSALEKAPAKKEAYRWKAtnPVEVKKEPVATPKALKKALEHEKTPE 511
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
 651-731 2.73e-03

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 40.65  E-value: 2.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 651 TGDSGAPPVPPTGdsgappvPPTGDAGPPPVPPTGDSGAPPvpptgdSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGD 730
Cdd:TIGR00601  81 TGKVAPPAATPTS-------APTPTPSPPASPASGMSAAPA------SAVEEKSPSEESATATAPESPSTSVPSSGSDAA 147


                  .
gi 1547055316 731 S 731
Cdd:TIGR00601 148 S 148
PHA03201 PHA03201
uracil DNA glycosylase; Provisional
 558-642 2.88e-03

uracil DNA glycosylase; Provisional


Pssm-ID: 165468  Cd Length: 318  Bit Score: 40.65  E-value: 2.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 558 TPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPvPPTGDSGAPPVPPTGDSGAP-P 636
Cdd:PHA03201    8 SPSPPRRPSPPRPTPPRSPDASPEETPPSPPGPGAEPPPGRAAGPAAPRRRPRGCPA-GVTFSSSAPPRPPLGLDDAPaA 86


                  ....*.
gi 1547055316 637 VPPTGD 642
Cdd:PHA03201   87 TPPPLD 92
PRK14965 PRK14965
DNA polymerase III subunits gamma and tau; Provisional
 588-687 2.92e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237871 [Multi-domain]  Cd Length: 576  Bit Score: 40.88  E-value: 2.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 588 SGAPPVPPTGDSGAPPVPPtgdSGAPPvpptgdSGAPPVpptgdsgaPPVPPTGDSGAPPVPptgdsgaPPVPPtgdsgA 667
Cdd:PRK14965  379 RGAPAPPSAAWGAPTPAAP---AAPPP------AAAPPV--------PPAAPARPAAARPAP-------APAPP-----A 429

                          90       100
                  ....*....|....*....|
gi 1547055316 668 PPVPPTGDAGPPPVPPTGDS 687
Cdd:PRK14965  430 AAAPPARSADPAAAASAGDR 449
PRK12495 PRK12495
hypothetical protein; Provisional
 597-699 2.97e-03

hypothetical protein; Provisional


Pssm-ID: 183558 [Multi-domain]  Cd Length: 226  Bit Score: 39.85  E-value: 2.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 597 GDSG-APPVPPTGDSGAPPVPPTgDSGAPPVPPTGDSGAPPVPPTGD-SGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTG 674
Cdd:PRK12495   76 DDAGdGAEATAPSDAGSQASPDD-DAQPAAEAEAADQSAPPEASSTSaTDEAATDPPATAAARDGPTPDPTAQPATPDER 154

                          90       100
                  ....*....|....*....|....*
gi 1547055316 675 DAGPPPVPPTGDSGAPPVPPTGDSG 699
Cdd:PRK12495  155 RSPRQRPPVSGEPPTPSTPDAHVAG 179
PRK11633 PRK11633
cell division protein DedD; Provisional
 571-696 3.01e-03

cell division protein DedD; Provisional


Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 39.99  E-value: 3.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 571 VPPTGDS-ETAPVPPTGDSgAPPVPPTGDSGAppvPPTGDSGAPPVPPTgDSGAPPVPPtgdsgAPPVPPTGDSGAPPVP 649
Cdd:PRK11633   44 VPKPGDRdEPDMMPAATQA-LPTQPPEGAAEA---VRAGDAAAPSLDPA-TVAPPNTPV-----EPEPAPVEPPKPKPVE 113

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1547055316 650 ptgdsgaPPVPPTGDSGAPPVPPTGDAGPPPVPPtgdsgaPPVPPTG 696
Cdd:PRK11633  114 -------KPKPKPKPQQKVEAPPAPKPEPKPVVE------EKAAPTG 147
PRK12438 PRK12438
hypothetical protein; Provisional
 632-685 3.06e-03

hypothetical protein; Provisional


Pssm-ID: 171499 [Multi-domain]  Cd Length: 991  Bit Score: 41.00  E-value: 3.06e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1547055316 632 SGAPPVPPTGDSGAPPvpPTGdsGAPPVPPtgdsgaPPVPPTGDAGPPPVPPTG 685
Cdd:PRK12438  899 TGRVATAPGGDAASAP--PPG--AGPPAPP------QAVPPPRTTQPPAAPPRG 942
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 550-625 3.28e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 41.03  E-value: 3.28e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1547055316  550 PTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPT-GDSGAPPVPPTGDSGAPPVPPTGDSGAPP 625
Cdd:PRK12270    39 GSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKpAAAAAAAAAPAAPPAAAAAAAPAAAAVED 115
Pneumo_att_G pfam05539
Pneumovirinae attachment membrane glycoprotein G;
560-729 3.33e-03

Pneumovirinae attachment membrane glycoprotein G;


Pssm-ID: 114270 [Multi-domain]  Cd Length: 408  Bit Score: 40.42  E-value: 3.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 560 VPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPptgdSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTgdSGAPPVPP 639
Cdd:pfam05539 167 EPKTAVTTSKTTSWPTEVSHPTYPSQVTPQSQPAT----QGHQTATANQRLSSTEPVGTQGTTTSSNPEP--QTEPPPSQ 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 640 TGDSGAPPVPPTGDSgaPPVPPTGDSGA-PPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTG 718
Cdd:pfam05539 241 RGPSGSPQHPPSTTS--QDQSTTGDGQEhTQRRKTPPATSNRRSPHSTATPPPTTKRQETGRPTPRPTATTQSGSSPPHS 318

                         170
                  ....*....|.
gi 1547055316 719 DSGAPPVPPTG 729
Cdd:pfam05539 319 SPPGVQANPTT 329
PHA03291 PHA03291
envelope glycoprotein I; Provisional
 580-684 3.55e-03

envelope glycoprotein I; Provisional


Pssm-ID: 223033 [Multi-domain]  Cd Length: 401  Bit Score: 40.32  E-value: 3.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 580 APVPPTGDSGAPPVPPTGDSGA--PPVPPTGDSGAP-----PVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTG 652
Cdd:PHA03291  164 AAFPAEGTLAAPPLGEGSADGScdPALPLSAPRLGPadvfvPATPRPTPRTTASPETTPTPSTTTSPPSTTIPAPSTTIA 243

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1547055316 653 DSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPT 684
Cdd:PHA03291  244 APQAGTTPEAEGTPAPPTPGGGEAPPANATPA 275
motB PRK12799
flagellar motor protein MotB; Reviewed
 563-698 3.63e-03

flagellar motor protein MotB; Reviewed


Pssm-ID: 183756 [Multi-domain]  Cd Length: 421  Bit Score: 40.47  E-value: 3.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 563 TGDSEATPVPPTGDSETAPVPPTGDSGAPpvpptgdsgAPPVPPTGDSGaPPVPPTGDSgAPPVPPTGDSGAPPVPPtGD 642
Cdd:PRK12799  296 HGTVPVAAVTPSSAVTQSSAITPSSAAIP---------SPAVIPSSVTT-QSATTTQAS-AVALSSAGVLPSDVTLP-GT 363

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1547055316 643 SGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPP-PVPPTGDSGAPPVPPTGDS 698
Cdd:PRK12799  364 VALPAAEPVNMQPQPMSTTETQQSSTGNITSTANGPTtSLPAAPASNIPVSPTSRDA 420
PRK12438 PRK12438
hypothetical protein; Provisional
 643-704 3.69e-03

hypothetical protein; Provisional


Pssm-ID: 171499 [Multi-domain]  Cd Length: 991  Bit Score: 41.00  E-value: 3.69e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1547055316 643 SGAPPVPPTGDSGAPpvPPTGdsGAPPVPPTgdAGPPPVPPTgdsgaPPVPPTGDSGAPPVT 704
Cdd:PRK12438  899 TGRVATAPGGDAASA--PPPG--AGPPAPPQ--AVPPPRTTQ-----PPAAPPRGPDVPPAA 949
Not5 COG5665
CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription];
571-745 3.69e-03

CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription];


Pssm-ID: 444384 [Multi-domain]  Cd Length: 874  Bit Score: 40.80  E-value: 3.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 571 VPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGappvpPTGDSGAPPVPPTgdSGAPPVpptgdsgAPPVPP 650
Cdd:COG5665   244 ATPPATPATEEKSSQQPKSQPTSPSGGTTPPSTNQLTTSNT-----PTSTAKAQPQPPT--KKQPAK-------EPPSDT 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 651 TGDSGAPPVPPTgDSGAPPVPPTGDAGPPPVPPTGDSGAP---PVPP-----TGDSGAPPVTPT-----------GDSET 711
Cdd:COG5665   310 ASGNPSAPSVLI-NSDSPTSEDPATASVPTTEETTAFTTPssvPSTPaekdtPATDLATPVSPTppetsvdkkvsPDSAT 388

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1547055316 712 APVPPTGDSGAP--PVPP-TGDSEAAPVPPTDDSKEA 745
Cdd:COG5665   389 SSTKSEKEGGTAssPMPPnIAIGAKDDVDATDPSQEA 425
PRK12495 PRK12495
hypothetical protein; Provisional
 575-688 3.73e-03

hypothetical protein; Provisional


Pssm-ID: 183558 [Multi-domain]  Cd Length: 226  Bit Score: 39.47  E-value: 3.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 575 GDSETAPVPPTGDSgaPPVPPTGDSGAPPVPPTgDSGAPPVPPTGDSGAPPVPPTGD-SGAPPVPPTGDSGAPPVPPTGD 653
Cdd:PRK12495   68 VTEDGAAGDDAGDG--AEATAPSDAGSQASPDD-DAQPAAEAEAADQSAPPEASSTSaTDEAATDPPATAAARDGPTPDP 144

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1547055316 654 SGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSG 688
Cdd:PRK12495  145 TAQPATPDERRSPRQRPPVSGEPPTPSTPDAHVAG 179
PLN02983 PLN02983
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 567-664 3.84e-03

biotin carboxyl carrier protein of acetyl-CoA carboxylase


Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 39.82  E-value: 3.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 567 EATPVPPTgdseTAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTgdsgaPPVPPTGDSGAPPV--PPTGDSG 644
Cdd:PLN02983  139 EALPQPPP----PAPVVMMQPPPPHAMPPASPPAAQPAPSAPASSPPPTPAS-----PPPAKAPKSSHPPLksPMAGTFY 209

                          90       100
                  ....*....|....*....|
gi 1547055316 645 APPVPptgdsGAPPVPPTGD 664
Cdd:PLN02983  210 RSPAP-----GEPPFVKVGD 224
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 675-749 3.95e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 40.64  E-value: 3.95e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1547055316  675 DAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMPA 749
Cdd:PRK12270    35 DYGPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPA 109
PRK14965 PRK14965
DNA polymerase III subunits gamma and tau; Provisional
 579-654 4.08e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237871 [Multi-domain]  Cd Length: 576  Bit Score: 40.50  E-value: 4.08e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1547055316 579 TAPVPPTGDSGAPPVPptgdsgAPPvPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPvPPTGDSGAPPVPPTGDS 654
Cdd:PRK14965  382 PAPPSAAWGAPTPAAP------AAP-PPAAAPPVPPAAPARPAAARPAPAPAPPAAAA-PPARSADPAAAASAGDR 449
KLF17_N cd21574
N-terminal domain of Kruppel-like factor 17; Kruppel-like factor 17 (KLF17), or Krueppel-like ...
 601-718 4.26e-03

N-terminal domain of Kruppel-like factor 17; Kruppel-like factor 17 (KLF17), or Krueppel-like factor 17, is a protein that, in humans, is encoded by the KLF17 gene and acts as a tumor suppressor. It negatively regulates epithelial-mesenchymal transition and metastasis in breast cancer. KLF17 is thought to be the human ortholog of the mouse gene, zinc finger protein 393 (Zfp393), although it has diverged significantly. KLF17 can regulate gene transcription from CACCC-box elements. It belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF17.


Pssm-ID: 410567  Cd Length: 286  Bit Score: 39.68  E-value: 4.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 601 APPVPPTGDSGAPPVPPTGDSGAPPVPPTGdSGAPPVPPTGdsgaPPVPPTgdSGAPPVPPTGdsgAPPVPptgDAGPPP 680
Cdd:cd21574   111 SPSQPGMMIFKGPQMMPLGEPNIPGVAMTF-SGNLRMPPSG----LPVSAS--SGIPMMSHIR---APTMP---YSGPPT 177

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1547055316 681 VPPTGDSG------APPVPPTGDSGAPP----VTPTGDSETAPVPPTG 718
Cdd:cd21574   178 VPSNRDSLtpkmllAPTMPSTEAQAVLPslaqMLPPRDPHNLGMPPAG 225
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 543-691 4.27e-03

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 40.48  E-value: 4.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 543 TLTYLALPTVTDQEATPVPPTGDSEATPVP-----PTGDSETAPVPPTGDSGAPPVPPtgDSGAPPVPPTGDSGAPPVPP 617
Cdd:PHA03269   11 TIACINLIIANLNTNIPIPELHTSAATQKPdpapaPHQAASRAPDPAVAPTSAASRKP--DLAQAPTPAASEKFDPAPAP 88

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1547055316 618 TGDSGAPPVPPTG-DSGAPPVPptgdsgAPPVPPTGDSGAPPvpptgdsgAPPVPPTGDAGPPPVPPTGDSGAPP 691
Cdd:PHA03269   89 HQAASRAPDPAVApQLAAAPKP------DAAEAFTSAAQAHE--------APADAGTSAASKKPDPAAHTQHSPP 149
PHA03369 PHA03369
capsid maturational protease; Provisional
 557-651 4.27e-03

capsid maturational protease; Provisional


Pssm-ID: 223061 [Multi-domain]  Cd Length: 663  Bit Score: 40.37  E-value: 4.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 557 ATPVPPTGDSEATPVPPTGdSETAPvPPTGDSGAPPVPPTGDSGAPPvPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPP 636
Cdd:PHA03369  351 ASLTAPSRVLAAAAKVAVI-AAPQT-HTGPADRQRPQRPDGIPYSVP-ARSPMTAYPPVPQFCGDPGLVSPYNPQSPGTS 427

                          90
                  ....*....|....*
gi 1547055316 637 VPPTGDSGAPPVPPT 651
Cdd:PHA03369  428 YGPEPVGPVPPQPTN 442
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 598-749 4.35e-03

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 39.93  E-value: 4.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 598 DSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPP--VPPTGDSGAPPvpptGDSGAPPVPPTGDSGAPPVPPTGD 675
Cdd:PTZ00436  192 DAAAAAAAKQKAAAKKAAAPSGKKSAKAAAPAKAAAAPAkaAAPPAKAAAAP----AKAAAAPAKAAAPPAKAAAPPAKA 267

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 676 AGPP--PVPPTGDSGAPP----VPPTGDSGAPPVTPTGDSETAPVPptGDSGAPPVPPTGDSEAAPVPPtddSKEAQMPA 749
Cdd:PTZ00436  268 AAPPakAAAPPAKAAAPPakaaAPPAKAAAAPAKAAAAPAKAAAAP--AKAAAPPAKAAAPPAKAATPP---AKAAAPPA 342
PHA03201 PHA03201
uracil DNA glycosylase; Provisional
 650-740 4.55e-03

uracil DNA glycosylase; Provisional


Pssm-ID: 165468  Cd Length: 318  Bit Score: 39.88  E-value: 4.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 650 PTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGdsetAPVPPTGDSGAPPVPPTG 729
Cdd:PHA03201    4 ARSRSPSPPRRPSPPRPTPPRSPDASPEETPPSPPGPGAEPPPGRAAGPAAPRRRPRG----CPAGVTFSSSAPPRPPLG 79

                          90
                  ....*....|...
gi 1547055316 730 --DSEAAPVPPTD 740
Cdd:PHA03201   80 ldDAPAATPPPLD 92
DUF4813 pfam16072
Domain of unknown function (DUF4813); This family of proteins is functionally uncharacterized. ...
 599-712 4.71e-03

Domain of unknown function (DUF4813); This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between 345 and 672 amino acids in length.


Pssm-ID: 435117 [Multi-domain]  Cd Length: 288  Bit Score: 39.74  E-value: 4.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 599 SGAPPVPPTGDSGAPPVPPTgdsgAPPVPPTGDSGAPPVPPTGDSGAP--PVPPTGDSGAPPVPPTGDSGAPPV---PPT 673
Cdd:pfam16072 156 SGTTVINAGGQQPAAPAAPA----YPVAPAAYPAQAPAAAPAPAPGAPqtPLAPLNPVAAAPAAAAGAAAAPVVaaaAPA 231

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1547055316 674 GDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETA 712
Cdd:pfam16072 232 AAAPPPPAPAAPPADAAPPAPGGIICVPVRVPEPDPKDA 270
PRK10856 PRK10856
cytoskeleton protein RodZ;
550-634 4.78e-03

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 40.01  E-value: 4.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 550 PTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVP-PTGDSGAPPVPPTGDsgAPPVPP 628
Cdd:PRK10856  170 TDPATTPAPAAPVDTTPTNSQTPAVATAPAPAVDPQQNAVVAPSQANVDTAATPAPaAPATPDGAAPLPTDQ--AGVSTP 247


                  ....*.
gi 1547055316 629 TGDSGA 634
Cdd:PRK10856  248 AADPNA 253
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
663-752 5.17e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 40.14  E-value: 5.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 663 GDSGAPPVPPTGDAGPPPVPPTgdSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDS 742
Cdd:PRK14971  366 GDDASGGRGPKQHIKPVFTQPA--AAPQPSAAAAASPSPSQSSAAAQPSAPQSATQPAGTPPTVSVDPPAAVPVNPPSTA 443

                          90
                  ....*....|
gi 1547055316 743 KEAQMPAVIR 752
Cdd:PRK14971  444 PQAVRPAQFK 453
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 634-752 5.39e-03

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 39.75  E-value: 5.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 634 APPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPtgDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAP 713
Cdd:NF040712  193 GRPLRPLATVPRLAREPADARPEEVEPAPAAEGAPATDS--DPAEAGTPDDLASARRRRAGVEQPEDEPVGPGAAPAAEP 270

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1547055316 714 VPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMPAVIR 752
Cdd:NF040712  271 DEATRDAGEPPAPGAAETPEAAEPPAPAPAAPAAPAAPE 309
motB PRK12799
flagellar motor protein MotB; Reviewed
 619-743 5.54e-03

flagellar motor protein MotB; Reviewed


Pssm-ID: 183756 [Multi-domain]  Cd Length: 421  Bit Score: 39.70  E-value: 5.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 619 GDSGAPPV---PPTGDSGAPPVPPTGDSGAP-----PVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAP 690
Cdd:PRK12799  294 DTHGTVPVaavTPSSAVTQSSAITPSSAAIPspaviPSSVTTQSATTTQASAVALSSAGVLPSDVTLPGTVALPAAEPVN 373

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1547055316 691 PVPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPvpptgDSEAAPVPPTDDSK 743
Cdd:PRK12799  374 MQPQPMSTTETQQSSTGNITSTANGPTTSLPAAP-----ASNIPVSPTSRDAQ 421
PRK11901 PRK11901
hypothetical protein; Reviewed
 607-743 6.13e-03

hypothetical protein; Reviewed


Pssm-ID: 237015 [Multi-domain]  Cd Length: 327  Bit Score: 39.67  E-value: 6.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 607 TGDSGAPPVPPTGDSGAPPVPPTGDSGAPpvpptGDSGAPPVPPTGDSGAPPVPPTGD--------------------SG 666
Cdd:PRK11901   88 SSGNQSSPSAANNTSDGHDASGVKNTAPP-----QDISAPPISPTPTQAAPPQTPNGQqrielpgnisdalsqqqgqvNA 162

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1547055316 667 APPVPPTGDAGPPPVPPTgdsgappVPPTGDSGAPPVTPTgdsetAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSK 743
Cdd:PRK11901  163 ASQNAQGNTSTLPTAPAT-------VAPSKGAKVPATAET-----HPTPPQKPATKKPAVNHHKTATVAVPPATSGK 227
PRK12438 PRK12438
hypothetical protein; Provisional
 665-724 6.15e-03

hypothetical protein; Provisional


Pssm-ID: 171499 [Multi-domain]  Cd Length: 991  Bit Score: 40.23  E-value: 6.15e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 665 SGAPPVPPTGDAGPPpvPPTGdsGAPPVPPTgdSGAPPVTPtgdseTAPVPPTGDSGAPP 724
Cdd:PRK12438  899 TGRVATAPGGDAASA--PPPG--AGPPAPPQ--AVPPPRTT-----QPPAAPPRGPDVPP 947
PRK14948 PRK14948
DNA polymerase III subunit gamma/tau;
651-745 6.54e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237862 [Multi-domain]  Cd Length: 620  Bit Score: 39.95  E-value: 6.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 651 TGDSGAPPVPPTGDSGAPPVPPtgdagPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVPPTGdSGAPPVPPTGD 730
Cdd:PRK14948  512 SQSGSASNTAKTPPPPQKSPPP-----PAPTPPLPQPTATAPPPTPPPPPPTATQASSNAPAQIPADS-SPPPPIPEEPT 585

                          90
                  ....*....|....*
gi 1547055316 731 SEAAPVPPTDDSKEA 745
Cdd:PRK14948  586 PSPTKDSSPEEIDKA 600
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 564-650 6.63e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 39.87  E-value: 6.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316  564 GDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPptgdsgAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDS 643
Cdd:PRK12270    39 GSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAP------AAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAA 112


                   ....*..
gi 1547055316  644 GAPPVPP 650
Cdd:PRK12270   113 VEDEVTP 119
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 127-218 6.71e-03

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 39.13  E-value: 6.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 127 GAFLMGSGHGANfLNNYLYDGEEIATRGnVIVVTFNYRvgplGF-LSTGDanlPGNYGLRDQHMAIAWVKRNIAAFGGDP 205
Cdd:COG1073    38 PAVVVAHGNGGV-KEQRALYAQRLAELG-FNVLAFDYR----GYgESEGE---PREEGSPERRDARAAVDYLRTLPGVDP 108

                          90
                  ....*....|...
gi 1547055316 206 NNITLFGESAGGA 218
Cdd:COG1073   109 ERIGLLGISLGGG 121
PHA03291 PHA03291
envelope glycoprotein I; Provisional
 633-752 7.04e-03

envelope glycoprotein I; Provisional


Pssm-ID: 223033 [Multi-domain]  Cd Length: 401  Bit Score: 39.55  E-value: 7.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 633 GAPPVPPTGDSGAPPVPPTGDSGA--PPVPPTgdsgAPPVPPTGDAGPPPVPPTGDSGAPPvpptgDSGAPPVTPTGDSE 710
Cdd:PHA03291  162 GLAAFPAEGTLAAPPLGEGSADGScdPALPLS----APRLGPADVFVPATPRPTPRTTASP-----ETTPTPSTTTSPPS 232

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1547055316 711 TAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDSKEAQMPAVIR 752
Cdd:PHA03291  233 TTIPAPSTTIAAPQAGTTPEAEGTPAPPTPGGGEAPPANATP 274
PRK10856 PRK10856
cytoskeleton protein RodZ;
655-753 7.08e-03

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 39.24  E-value: 7.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 655 GAPPVPPTGDSGAPPVP---PTGDAGPPPVPPTGdsgappvPPTGDSGAPPVTPTGDSETAPVPPTGDSGAPPVP-PTGD 730
Cdd:PRK10856  158 SGQSVPLDTSTTTDPATtpaPAAPVDTTPTNSQT-------PAVATAPAPAVDPQQNAVVAPSQANVDTAATPAPaAPAT 230

                          90       100
                  ....*....|....*....|....*...
gi 1547055316 731 SEAAPVPPTDDSKEAQMPA-----VIRF 753
Cdd:PRK10856  231 PDGAAPLPTDQAGVSTPAAdpnalVMNF 258
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 552-703 7.21e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 39.85  E-value: 7.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 552 VTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAP--PVPPTGDSGAPPVPPTgdsgAPPVPPTGDSGAPPVPPT 629
Cdd:PRK07994  369 EVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQqaPAVPLPETTSQLLAAR----QQLQRAQGATKAKKSEPA 444

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1547055316 630 GDSGAPPVPPTGDSGApPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPV 703
Cdd:PRK07994  445 AASRARPVNSALERLA-SVRPAPSALEKAPAKKEAYRWKATNPVEVKKEPVATPKALKKALEHEKTPELAAKLA 517
flhF PRK06995
flagellar biosynthesis protein FlhF;
601-701 7.45e-03

flagellar biosynthesis protein FlhF;


Pssm-ID: 235904 [Multi-domain]  Cd Length: 484  Bit Score: 39.56  E-value: 7.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 601 APPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPP 680
Cdd:PRK06995   52 APPAAAAPAAAQPPPAAAPAAVSRPAAPAAEPAPWLVEHAKRLTAQREQLVARAAAPAAPEAQAPAAPAERAAAENAARR 131

                          90       100
                  ....*....|....*....|.
gi 1547055316 681 VPPTGDSGAPPVPPTGDSGAP 701
Cdd:PRK06995  132 LARAAAAAPRPRVPADAAAAV 152
KLF9_13_N-like cd21975
Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins; Kruppel/Krueppel-like ...
 576-705 7.58e-03

Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved alpha-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the related N-terminal domains of KLF9, KLF13, KLF14, KLF16, and similar proteins.


Pssm-ID: 409240 [Multi-domain]  Cd Length: 163  Bit Score: 38.13  E-value: 7.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 576 DSETAPVPPTGDSGAP--PVPPTGDSGAPPVPPTGDSGAPPVPPT--------GDSGAPPVppTGDSGAPPVPPTGdsga 645
Cdd:cd21975    24 DPEGAGLAAGLDVRATreVAKGPGPPGPAWKPDGADSPGLVTAAPhllaanvlAPLRGPSV--EGSSLESGDADMG---- 97

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 646 PPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTP 705
Cdd:cd21975    98 SDSDVAPASGAAASTSPESSSDAASSPSPLSLLHPGEAGLEPERPRPRVRRGVRRRGVTP 157
PHA03291 PHA03291
envelope glycoprotein I; Provisional
 550-640 8.30e-03

envelope glycoprotein I; Provisional


Pssm-ID: 223033 [Multi-domain]  Cd Length: 401  Bit Score: 39.17  E-value: 8.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 550 PTVTDQEATPVPPTgdseATPVPPtgdsETAPVPPTGDSGAPPVPPtGDSGAPPVPPTGDSGAPPVPPtgdsgAPPVPPT 629
Cdd:PHA03291  199 PADVFVPATPRPTP----RTTASP----ETTPTPSTTTSPPSTTIP-APSTTIAAPQAGTTPEAEGTP-----APPTPGG 264

                          90
                  ....*....|.
gi 1547055316 630 GDSGAPPVPPT 640
Cdd:PHA03291  265 GEAPPANATPA 275
DamX COG3266
Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell ...
 556-691 8.35e-03

Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442497 [Multi-domain]  Cd Length: 455  Bit Score: 39.45  E-value: 8.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 556 EATPVPPTGDSEATPVPPTGDSETAPvPPTGDSGAPPVPPTGDSGAPPVPPTGDsGAPPVPPTGDSGAP--PVPPTGDSG 633
Cdd:COG3266   233 AAGAAEVLTARLVLLLLIIGSALKAP-SQASSASAPATTSLGEQQEVSLPPAVA-AQPAAAAAAQPSAValPAAPAAAAA 310

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1547055316 634 AP-PVPPTgdsgaPPVPPTgdsgAPPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPP 691
Cdd:COG3266   311 AAaPAEAA-----APQPTA----AKPVVTETAAPAAPAPEAAAAAAAPAAPAVAKKLAA 360
half-pint TIGR01645
poly-U binding splicing factor, half-pint family; The proteins represented by this model ...
 539-667 8.36e-03

poly-U binding splicing factor, half-pint family; The proteins represented by this model contain three RNA recognition motifs (rrm: pfam00076) and have been characterized as poly-pyrimidine tract binding proteins associated with RNA splicing factors. In the case of PUF60 (GP|6176532), in complex with p54, and in the presence of U2AF, facilitates association of U2 snRNP with pre-mRNA.


Pssm-ID: 130706 [Multi-domain]  Cd Length: 612  Bit Score: 39.67  E-value: 8.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 539 LRYWTLTYLALPTVTDQEATPVPPTGDSEATPVPPTGDSETAPVPPTGDSGAPPVPPTGDSGAPPVPPTGdSGAPPVPPT 618
Cdd:TIGR01645 326 PRAQSPATPSSSLPTDIGNKAVVSSAKKEAEEVPPLPQAAPAVVKPGPMEIPTPVPPPGLAIPSLVAPPG-LVAPTEINP 404

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1547055316 619 GDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGA 667
Cdd:TIGR01645 405 SFLASPRKKMKREKLPVTFGALDDTLAWKEPSKEDQTSEDGKMLAIMGE 453
PRK12438 PRK12438
hypothetical protein; Provisional
 610-663 8.42e-03

hypothetical protein; Provisional


Pssm-ID: 171499 [Multi-domain]  Cd Length: 991  Bit Score: 39.84  E-value: 8.42e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1547055316 610 SGAPPVPPTGDSGAPpvPPTGdsGAPPVPPtgdsgaPPVPPTGDSGAPPVPPTG 663
Cdd:PRK12438  899 TGRVATAPGGDAASA--PPPG--AGPPAPP------QAVPPPRTTQPPAAPPRG 942
PRK12438 PRK12438
hypothetical protein; Provisional
 599-652 8.42e-03

hypothetical protein; Provisional


Pssm-ID: 171499 [Multi-domain]  Cd Length: 991  Bit Score: 39.84  E-value: 8.42e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1547055316 599 SGAPPVPPTGDSGAPpvPPTGdsGAPPVPPtgdsgaPPVPPTGDSGAPPVPPTG 652
Cdd:PRK12438  899 TGRVATAPGGDAASA--PPPG--AGPPAPP------QAVPPPRTTQPPAAPPRG 942
PRK12438 PRK12438
hypothetical protein; Provisional
 588-641 8.42e-03

hypothetical protein; Provisional


Pssm-ID: 171499 [Multi-domain]  Cd Length: 991  Bit Score: 39.84  E-value: 8.42e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1547055316 588 SGAPPVPPTGDSGAPpvPPTGdsGAPPVPPtgdsgaPPVPPTGDSGAPPVPPTG 641
Cdd:PRK12438  899 TGRVATAPGGDAASA--PPPG--AGPPAPP------QAVPPPRTTQPPAAPPRG 942
PRK14965 PRK14965
DNA polymerase III subunits gamma and tau; Provisional
 621-707 8.98e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237871 [Multi-domain]  Cd Length: 576  Bit Score: 39.34  E-value: 8.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 621 SGAPPVPPTGDSGAPPVPPtgdSGAPPvpptgdSGAPPVPPTgdSGAPPVpptgdAGPPPVPPTGDSGAPPVPPTGDSGA 700
Cdd:PRK14965  379 RGAPAPPSAAWGAPTPAAP---AAPPP------AAAPPVPPA--APARPA-----AARPAPAPAPPAAAAPPARSADPAA 442


                  ....*..
gi 1547055316 701 PPVTPTG 707
Cdd:PRK14965  443 AASAGDR 449
PHA03169 PHA03169
hypothetical protein; Provisional
 641-748 9.17e-03

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 39.18  E-value: 9.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547055316 641 GDSGAPPVPPTGDSGAPPVPPTGDSGAPPVPPTGDaGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTG-------DSETAP 713
Cdd:PHA03169  100 VGSPTPSPSGSAEELASGLSPENTSGSSPESPASH-SPPPSPPSHPGPHEPAPPESHNPSPNQQPSSflqpsheDSPEEP 178

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1547055316 714 VPPTG----DSGAPPVPPTGDSEAAPVPPTDDSKEAQMP 748
Cdd:PHA03169  179 EPPTSepepDSPGPPQSETPTSSPPPQSPPDEPGEPQSP 217
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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