|
Name |
Accession |
Description |
Interval |
E-value |
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
218-468 |
7.55e-54 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 186.65 E-value: 7.55e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 218 WQSRPLKRLARAARDLALGSPSAALEERGASELVEVARAFNTMHERIDRYLNERGQLFSAISHDLRTPITRLRLRVELL- 296
Cdd:PRK09467 176 IQNRPLVALEHAALQVGKGEIPPPLREYGASEVRSVTRAFNQMAAGIKQLEDDRTLLMAGVSHDLRTPLTRIRLATEMMs 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 297 -EDERLQEKFGRDLDELELLVKGALQCVKdTDIHENVEPVDLNLLLQHIAEPYLADGRVEVVGRAAEPY--PGKPLALKR 373
Cdd:PRK09467 256 eEDGYLAESINKDIEECNAIIEQFIDYLR-TGQEMPMEMADLNALLGEVIAAESGYEREIETALQPGPIevPMNPIAIKR 334
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 374 CIGNLLDNALKYGE-RARLSLEDGPEAVALHVDDDGPGVPEQRLEQIFEPRFR-LSPRG-QGYGLGLGIARNIAHTHGGE 450
Cdd:PRK09467 335 ALANLVVNAARYGNgWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRgDSARGsSGTGLGLAIVKRIVDQHNGK 414
|
250
....*....|....*...
gi 1544655203 451 VSLQNRREGGLRVSLRLP 468
Cdd:PRK09467 415 VELGNSEEGGLSARAWLP 432
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
162-469 |
4.28e-43 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 155.07 E-value: 4.28e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 162 VLVTQIRIGDSEWLYIASLMPAPYVSLEPEGLQPQQVLSIVFTSLLLLLFTGLLMHWQSRPLKRLARAARDLALGSPSAA 241
Cdd:COG0642 1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 242 LEERGASELVEVARAFNTMHERIDRYLNERGQLFSAISHDLRTPITRLRLRVELLE---DERLQEKFG---RDLDELELL 315
Cdd:COG0642 81 LLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLeelDEEQREYLEtilRSADRLLRL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 316 VKGALQCVK--DTDIHENVEPVDLNLLLQHIAE---PYLADGRVEVVGRAAEPYP---GKPLALKRCIGNLLDNALKY-- 385
Cdd:COG0642 161 INDLLDLSRleAGKLELEPEPVDLAELLEEVVElfrPLAEEKGIELELDLPDDLPtvrGDPDRLRQVLLNLLSNAIKYtp 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 386 -GERARLSLEDGPEAVALHVDDDGPGVPEQRLEQIFEPRFRLSP--RGQGYGLGLGIARNIAHTHGGEVSLQNRREGGLR 462
Cdd:COG0642 241 eGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPsrRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTT 320
|
....*..
gi 1544655203 463 VSLRLPR 469
Cdd:COG0642 321 FTVTLPL 327
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
217-468 |
6.45e-40 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 148.98 E-value: 6.45e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 217 HWQSrpLKRLARAARDLALGSPSAALEERGASELVEVARAFNTMHERIDRYLNERGQLFSAISHDLRTPITRLRLRVELL 296
Cdd:PRK10604 160 HWQD--MLKLEAAAQRLGDGHLAERIHFDEGSSLERLGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEMS 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 297 EDERLQEKFG--RDLDELELLVKGALQCVK----DTDIHenVEPVDLNLLLQHIAEPYLAdGRVEVVGRAAEPYPGKPLA 370
Cdd:PRK10604 238 DNLSAAESQAlnRDIGQLEALIEELLTYARldrpQNELH--LSEPDLPAWLSTHLADIQA-VTPEKTVRLDTPHQGDYGA 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 371 -----LKRCIGNLLDNALKY-GERARLSLEDGPEAVALHVDDDGPGVPEQRLEQIFEPRFRLSP----RGQGYGLGLGIA 440
Cdd:PRK10604 315 ldmrlMERVLDNLLNNALRYaHSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPsrdrATGGCGLGLAIV 394
|
250 260
....*....|....*....|....*...
gi 1544655203 441 RNIAHTHGGEVSLQNRREGGLRVSLRLP 468
Cdd:PRK10604 395 HSIALAMGGSVNCDESELGGARFSFSWP 422
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
256-469 |
4.24e-37 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 136.19 E-value: 4.24e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 256 AFNTMHERIDRYLNERGQLFSAISHDLRTPITRLRLRVELLED------ERLQEKFG---RDLDELELLVKGALQ--CVK 324
Cdd:COG2205 1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDeedlspEERRELLEiirESAERLLRLIEDLLDlsRLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 325 DTDIHENVEPVDLNLLLQHIAE---PYLADGRVEVVGRAAEPYP---GKPLALKRCIGNLLDNALKY---GERARLSLED 395
Cdd:COG2205 81 SGKLSLELEPVDLAELLEEAVEelrPLAEEKGIRLELDLPPELPlvyADPELLEQVLANLLDNAIKYsppGGTITISARR 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1544655203 396 GPEAVALHVDDDGPGVPEQRLEQIFEPRFRLSPRG--QGYGLGLGIARNIAHTHGGEVSLQNRREGGLRVSLRLPR 469
Cdd:COG2205 161 EGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRgeGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPL 236
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
162-469 |
3.16e-36 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 137.76 E-value: 3.16e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 162 VLVTQIRIGDSEWLYIASLMPAPYVSLEPEGLQPQQVLSIVFTSLLLLLFTGLLMHWQSRPLKRLARAARDLALGSPSAA 241
Cdd:COG5002 59 LLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRL 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 242 LEERGASELVEVARAFNTMHERIDRylnERGQLFSAISHDLRTPITRLRLRVELLEDERL-----QEKF----GRDLDEL 312
Cdd:COG5002 139 SALLLGLLLLAAVERDITELERLEQ---MRREFVANVSHELRTPLTSIRGYLELLLDGAAddpeeRREYleiiLEEAERL 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 313 ELLVKGALQCVK--DTDIHENVEPVDLNLLLQHIAE---PYLADGRVEVVGRAAEPYP---GKPLALKRCIGNLLDNALK 384
Cdd:COG5002 216 SRLVNDLLDLSRleSGELKLEKEPVDLAELLEEVVEelrPLAEEKGIELELDLPEDPLlvlGDPDRLEQVLTNLLDNAIK 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 385 Y---GERARLSLEDGPEAVALHVDDDGPGVPEQRLEQIFEPRFRL----SPRGQGYGLGLGIARNIAHTHGGEVSLQNRR 457
Cdd:COG5002 296 YtpeGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVdksrSRETGGTGLGLAIVKHIVEAHGGRIWVESEP 375
|
330
....*....|..
gi 1544655203 458 EGGLRVSLRLPR 469
Cdd:COG5002 376 GKGTTFTITLPL 387
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
218-471 |
1.86e-34 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 134.59 E-value: 1.86e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 218 WQSRPLKRLARAARDLALGSPsAALEERGASELVEVARAFNTMHER------IDRYLNergqlfsAISHDLRTPITRLRL 291
Cdd:PRK11100 205 WLNRSIRRLTRYADAVTEGKP-VPLPKLGSSELRELAQALESMRVKlegkayVEQYVQ-------TLTHELKSPLAAIRG 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 292 RVELLEDE------------------RLQEKFGRDLDELELLVKGALqcvkdtdihENVEPVDLNLLLQHIA---EPYLA 350
Cdd:PRK11100 277 AAELLQEDpppedrarftgniltqsaRLQQLIDRLLELARLEQRQEL---------EVLEPVALAALLEELVearEAQAA 347
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 351 DGRVEVVGRAAEPY-PGKPLALKRCIGNLLDNALKY---GERARLSLEDGPEAVALHVDDDGPGVPEQRLEQIFEpRFRL 426
Cdd:PRK11100 348 AKGITLRLRPDDARvLGDPFLLRQALGNLLDNAIDFspeGGTITLSAEVDGEQVALSVEDQGPGIPDYALPRIFE-RFYS 426
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 1544655203 427 SPRGQG----YGLGLGIARNIAHTHGGEVSLQNRREGGLRVSLRLPRLG 471
Cdd:PRK11100 427 LPRPANgrksTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPRHF 475
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
220-468 |
8.54e-33 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 129.67 E-value: 8.54e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 220 SRPLKRLARAARDLALGSPSAALE-ERGASELVEVARAFNTMHERIDRYLNERGQLFSAISHDLRTPITRLRLRVELL-- 296
Cdd:PRK09470 191 AKPARKLKNAADEVAQGNLRQHPElETGPQEFRQAGASFNQMVTALERMMTSQQRLLSDISHELRTPLTRLQLATALLrr 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 297 ------EDERLQEKFGRdLDEL--ELLVKGALQcVKDtdiHENVEPVDLNLLLQHIaepyLADGRVE--------VVGRA 360
Cdd:PRK09470 271 rqgeskELERIETEAQR-LDSMinDLLVLSRNQ-QKN---HLERETFKANSLWSEV----LEDAKFEaeqmgkslTVSAP 341
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 361 AEPYP--GKPLALKRCIGNLLDNALKYG-ERARLSLEDGPEAVALHVDDDGPGVPEQRLEQIFEPRFRLS-PRGQ---GY 433
Cdd:PRK09470 342 PGPWPinGNPNALASALENIVRNALRYShTKIEVAFSVDKDGLTITVDDDGPGVPEEEREQIFRPFYRVDeARDResgGT 421
|
250 260 270
....*....|....*....|....*....|....*
gi 1544655203 434 GLGLGIARNIAHTHGGEVSLQNRREGGLRVSLRLP 468
Cdd:PRK09470 422 GLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWLP 456
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
371-467 |
1.84e-28 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 108.07 E-value: 1.84e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 371 LKRCIGNLLDNALKY---GERARLSLEDGPEAVALHVDDDGPGVPEQRLEQIFEPRFRLSP--RGQGYGLGLGIARNIAH 445
Cdd:cd00075 1 LEQVLSNLLDNALKYsppGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKsrEGGGTGLGLAIVRRIVE 80
|
90 100
....*....|....*....|..
gi 1544655203 446 THGGEVSLQNRREGGLRVSLRL 467
Cdd:cd00075 81 AHGGRITVESEPGGGTTFTVTL 102
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
222-468 |
4.41e-27 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 113.38 E-value: 4.41e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 222 PLKRLARAARDLALGSPSAALEERGASELVEVARAFNTMHERIDRYLNERGQLFSAISHDLRTPITRLRLRVELLED--- 298
Cdd:NF012163 191 PVKRLVEATHRLAAGDYTTRVTPTSNDELGKLAQDFNQLASTLEKNEQMRRDFMADISHELRTPLAVLRAELEAIQDgir 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 299 -------ERLQ------EKFGRDLDELELLVKGALQCVKdtdihenvEPVDLNLLLQHIAE---PYLADG--RVEVVGRA 360
Cdd:NF012163 271 kftpeslDSLQaevgtlTKLVDDLHDLSMSDEGALAYQK--------ASVDLVPLLEVEGGafrERFASAglELEVSLPD 342
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 361 AEPYPGKPLALKRCIGNLLDNALKY---GERARLSLEDGPEAVALHVDDDGPGVPEQRLEQIFEPRFRL-SPRGQ---GY 433
Cdd:NF012163 343 SSLVFGDRDRLMQLFNNLLENSLRYtdsGGSLHISASQRPKEVTLTVADSAPGVSDEQLARLFERFYRVeVSRNRasgGS 422
|
250 260 270
....*....|....*....|....*....|....*
gi 1544655203 434 GLGLGIARNIAHTHGGEVSLQNRREGGLRVSLRLP 468
Cdd:NF012163 423 GLGLAISLNIVQAHGGTLHAAHSPLGGLRIVVTLP 457
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
366-468 |
7.97e-27 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 103.88 E-value: 7.97e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 366 GKPLALKRCIGNLLDNALKYGERA---RLSLEDGPEAVALHVDDDGPGVPEQRLEQIFEPRFRLSPR---GQGYGLGLGI 439
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGgriTVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRsrkIGGTGLGLSI 80
|
90 100
....*....|....*....|....*....
gi 1544655203 440 ARNIAHTHGGEVSLQNRREGGLRVSLRLP 468
Cdd:smart00387 81 VKKLVELHGGEISVESEPGGGTTFTITLP 109
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
272-471 |
3.26e-26 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 110.05 E-value: 3.26e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 272 GQLFSAISHDLRTPITRLRLRVELLEdERLQEKFGRDLDELELLVKGALQCVKDTD--IHE----------NVEPVDLNL 339
Cdd:COG5000 202 GELARRIAHEIKNPLTPIQLSAERLR-RKLADKLEEDREDLERALDTIIRQVDRLKriVDEfldfarlpepQLEPVDLNE 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 340 LLQHIA---EPYLADGRVEVVGRAAEPYP---GKPLALKRCIGNLLDNAL---KYGERARLSLEDGPEAVALHVDDDGPG 410
Cdd:COG5000 281 LLREVLalyEPALKEKDIRLELDLDPDLPevlADRDQLEQVLINLLKNAIeaiEEGGEIEVSTRREDGRVRIEVSDNGPG 360
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1544655203 411 VPEQRLEQIFEPRFrlSPRGQGYGLGLGIARNIAHTHGGEVSLQNRREGGLRVSLRLPRLG 471
Cdd:COG5000 361 IPEEVLERIFEPFF--TTKPKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLAE 419
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
221-452 |
1.78e-25 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 108.63 E-value: 1.78e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 221 RPLKRLARAARDLALGSPSAALEERGAS-ELVEVARAFNTMHERIDRYLNERGQLFSAISHDLRTPITRLRLRVE-LLED 298
Cdd:TIGR01386 190 EPLRRLSAVAARISPESLDQRLDPSRAPaELRELAQSFNAMLGRLEDAFQRLSQFSADLAHELRTPLTNLLGQTQvALSQ 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 299 ERLQEKFgRD-----LDELELLVK-------------GALQCVK-DTDIHENVEpvDLNLLLQHIAEPYLADGRVEVVGR 359
Cdd:TIGR01386 270 PRTGEEY-REvlesnLEELERLSRmvsdmlflaradnGQLALERvRLDLAAELA--KVAEYFEPLAEERGVRIRVEGEGL 346
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 360 AaepyPGKPLALKRCIGNLLDNALKY---GERARLSLEDGPEAVALHVDDDGPGVPEQRLEQIFEPRFRLSPR----GQG 432
Cdd:TIGR01386 347 V----RGDPQMFRRAISNLLSNALRHtpdGGTITVRIERRSDEVRVSVSNPGPGIPPEHLSRLFDRFYRVDPArsnsGEG 422
|
250 260
....*....|....*....|
gi 1544655203 433 YGLGLGIARNIAHTHGGEVS 452
Cdd:TIGR01386 423 TGLGLAIVRSIMEAHGGRAS 442
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
272-469 |
6.92e-25 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 105.27 E-value: 6.92e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 272 GQLFSAISHDLRTPITRLRLRVELLEdERLQEKFGRD--LDELELLVKGALQCvkdTDI-----------HENVEPVDLN 338
Cdd:COG4191 143 GELAAGIAHEINNPLAAILGNAELLR-RRLEDEPDPEelREALERILEGAERA---AEIvrslrafsrrdEEEREPVDLN 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 339 LLLQ---HIAEPYLADGRVEVVGRAAEPYP---GKPLALKRCIGNLLDNAL-----KYGERARLSLEDGPEAVALHVDDD 407
Cdd:COG4191 219 ELIDealELLRPRLKARGIEVELDLPPDLPpvlGDPGQLEQVLLNLLINAIdameeGEGGRITISTRREGDYVVISVRDN 298
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1544655203 408 GPGVPEQRLEQIFEPRFRLSPRGQGYGLGLGIARNIAHTHGGEVSLQNRREGGLRVSLRLPR 469
Cdd:COG4191 299 GPGIPPEVLERIFEPFFTTKPVGKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPL 360
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
366-468 |
8.18e-25 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 98.59 E-value: 8.18e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 366 GKPLALKRCIGNLLDNALKY---GERARLSLEDGpEAVALHVDDDGPGVPEQRLEQIFEPRFR-LSPRGQGYGLGLGIAR 441
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHaakAGEITVTLSEG-GELTLTVEDNGIGIPPEDLPRIFEPFSTaDKRGGGGTGLGLSIVR 79
|
90 100
....*....|....*....|....*..
gi 1544655203 442 NIAHTHGGEVSLQNRREGGLRVSLRLP 468
Cdd:pfam02518 80 KLVELLGGTITVESEPGGGTTVTLTLP 106
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
221-466 |
1.90e-24 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 105.50 E-value: 1.90e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 221 RPLKRLARAardLALGSPSAAL---EERGASELVEVARAFNTMHERI-DRYLNERgQLFSAISHDLRTPITRLRLRVEL- 295
Cdd:PRK10337 187 APLKKLALA---LRMRDPDSETplnATGVPSEVRPLVEALNQLFARThAMMVRER-RFTSDAAHELRSPLAALKVQTEVa 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 296 ---LEDERLQEKFGRDLDE---------LELLVKGALQCVKDTDiheNVEPVDLNLLLQ-------HIAEPYLADGRVEV 356
Cdd:PRK10337 263 qlsDDDPQARKKALLQLHAgidratrlvDQLLTLSRLDSLDNLQ---DVAEIPLEDLLQsavmdiyHTAQQAGIDVRLTL 339
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 357 VGRAAePYPGKPLALKRCIGNLLDNALKY---GERARLSLEdgpeAVALHVDDDGPGVPEQRLEQIFEPRFRlsPRGQ-- 431
Cdd:PRK10337 340 NAHPV-IRTGQPLLLSLLVRNLLDNAIRYspqGSVVDVTLN----ARNFTVRDNGPGVTPEALARIGERFYR--PPGQea 412
|
250 260 270
....*....|....*....|....*....|....*.
gi 1544655203 432 -GYGLGLGIARNIAHTHGGEVSLQNRREGGLRVSLR 466
Cdd:PRK10337 413 tGSGLGLSIVRRIAKLHGMNVSFGNAPEGGFEAKVS 448
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
371-468 |
1.55e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 94.70 E-value: 1.55e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 371 LKRCIGNLLDNALKYG-ERARLSLEDGPEAVALHVDDDGPGVPEQRLEQIFEPRFRLSP----RGQGYGLGLGIARNIAH 445
Cdd:cd16949 1 LARALENVLRNALRYSpSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSardrESGGTGLGLAIAERAIE 80
|
90 100
....*....|....*....|...
gi 1544655203 446 THGGEVSLQNRREGGLRVSLRLP 468
Cdd:cd16949 81 QHGGKIKASNRKPGGLRVRIWLP 103
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
364-467 |
1.23e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 93.08 E-value: 1.23e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 364 YPGKPLALKRCIGNLLDNALKYG-ERARLSLEDGPEAVALHVDDDGPGVPEQRLEQIFEPRFRLSPRGQGYGLGLGIARN 442
Cdd:cd16954 31 FPGERNDLMELLGNLLDNACKWClEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDEQRPGQGLGLAIAKE 110
|
90 100
....*....|....*....|....*
gi 1544655203 443 IAHTHGGEVSLQNRREGGLRVSLRL 467
Cdd:cd16954 111 IVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
221-468 |
4.53e-21 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 95.47 E-value: 4.53e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 221 RPLKRLARAARDLALGSPSAALEERGASELVEVARAFNTMHERIDRYLNERGQLFSAISHDLRTPITRLRLRVELLED-- 298
Cdd:PRK10549 190 APVKRLVEGTHKLAAGDFTTRVTPTSRDELGRLAQDFNQLASTLEKNEQMRRDFMADISHELRTPLAVLRGELEAIQDgv 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 299 --------ERLQ------EKFGRDLDELELLVKGALQCVKdtdihenvEPVDLNLLLQHIAEPY---LADGRVEVVGRAA 361
Cdd:PRK10549 270 rkftpesvASLQaevgtlTKLVDDLHQLSLSDEGALAYRK--------TPVDLVPLLEVAGGAFrerFASRGLTLQLSLP 341
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 362 EPYP--GKPLALKRCIGNLLDNALKY---GERARLSLEDGPEAVALHVDDDGPGVPEQRLEQIFEPRFRL-SPRGQ---G 432
Cdd:PRK10549 342 DSATvfGDPDRLMQLFNNLLENSLRYtdsGGSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTeGSRNRasgG 421
|
250 260 270
....*....|....*....|....*....|....*.
gi 1544655203 433 YGLGLGIARNIAHTHGGEVSLQNRREGGLRVSLRLP 468
Cdd:PRK10549 422 SGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELP 457
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
66-469 |
4.80e-21 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 95.62 E-value: 4.80e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 66 RPLVLDQLRSMGGTRFFVSLNDRPLEMRALPDTPNKQAVLEIVQDVLHQRLGKEVELQVEFVSPDELRLFNGALKLDELP 145
Cdd:COG4251 77 ALALLLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLL 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 146 RSWAHYALTLEPVNPPVLVTQIRIGDSEWLYIASLMPAPYVSLEPEGLQPQQVLSIVFTSLLLLLFTGLLMHWQSRPLKR 225
Cdd:COG4251 157 LLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLV 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 226 LARAARDLALGSPSAALEERGASELVEVARAFNTMHERIDRYLNERGQLFSAISHDLRTPITRLRLRVELLEdERLQEKF 305
Cdd:COG4251 237 LLLLLILLLLLLILVLELLELRLELEELEEELEERTAELERSNEELEQFAYVASHDLREPLRKISGFSQLLE-EDYGDKL 315
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 306 GRDLDE-LELLVKGA----------LQCVKDTDIHENVEPVDLNLLLQHIAE---PYLADGRVEVVgraAEPYP---GKP 368
Cdd:COG4251 316 DEEGREyLERIRDAAermqaliddlLAYSRVGRQELEFEPVDLNELLEEVLEdlePRIEERGAEIE---VGPLPtvrGDP 392
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 369 LALKRCIGNLLDNALKYGERA-----RLSLEDGPEAVALHVDDDGPGVPEQRLEQIFEPRFRLSPRGQ--GYGLGLGIAR 441
Cdd:COG4251 393 TLLRQVFQNLISNAIKYSRPGeppriEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRDEyeGTGIGLAIVK 472
|
410 420
....*....|....*....|....*...
gi 1544655203 442 NIAHTHGGEVSLQNRREGGLRVSLRLPR 469
Cdd:COG4251 473 KIVERHGGRIWVESEPGEGATFYFTLPK 500
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
366-467 |
3.73e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 85.54 E-value: 3.73e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 366 GKPLALKRCIGNLLDNALKY---GERARLSLEDGPEAVaLHVDDDGPGVPEQRLEQIFEPRFRLSPR-GQGYGLGLGIAR 441
Cdd:cd16940 9 GDALLLFLLLRNLVDNAVRYspqGSRVEIKLSADDGAV-IRVEDNGPGIDEEELEALFERFYRSDGQnYGGSGLGLSIVK 87
|
90 100
....*....|....*....|....*.
gi 1544655203 442 NIAHTHGGEVSLQNRREGGLRVSLRL 467
Cdd:cd16940 88 RIVELHGGQIFLGNAQGGGLEAWVRL 113
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
371-469 |
6.80e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 84.40 E-value: 6.80e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 371 LKRCIGNLLDNALKYGER-ARLSLEDGPEAVALHVDDDGPGVPEQRLEQIFEPRFRLSPRGQ----GYGLGLGIARNIAH 445
Cdd:cd16939 1 MARALDNLLRNALRYAHRtVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDratgGFGLGLAIVHRVAL 80
|
90 100
....*....|....*....|....
gi 1544655203 446 THGGEVSLQNRREGGLRVSLRLPR 469
Cdd:cd16939 81 WHGGHVECDDSELGGACFRLTWPR 104
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
217-469 |
7.96e-20 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 90.41 E-value: 7.96e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 217 HWQSRPLKRL-----ARAARDLalgSPsaaLEERGAS-ELVEVARAFNTMHERIDRYL-NERgqLFSA-ISHDLRTPITR 288
Cdd:PRK10755 83 RWITRPLAELqkeleARTADNL---TP---IAIHSSTlEIEAVTSALNQLVSRLTSTLdQER--LFTAdVAHELRTPLAG 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 289 LRLRVELLEDERLQEK---FGRdLDELELLVKGALQCVK-----DTDIHENVEPVD---------LNLLLQhiaepyLAD 351
Cdd:PRK10755 155 IRLHLELLEKQHHIDVaplIAR-LDQMMHTVEQLLQLARagqsfSSGHYQTVKLLEdvilpsqdeLSEMLE------QRQ 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 352 GRVEVVGRAAEPY-PGKPLALKRCIGNLLDNALKY---GERARLSLEDGPEAVALHVDDDGPGVPEQRLEQIFEPRFRLS 427
Cdd:PRK10755 228 QTLLLPESAADITvQGDATLLRLLLRNLVENAHRYspeGSTITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVRMD 307
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 1544655203 428 PRGQGYGLGLGIARNIAHTHGGEVSLQNRRE-GGLRVSLRLPR 469
Cdd:PRK10755 308 SRYGGIGLGLSIVSRITQLHHGQFFLQNRQErSGTRAWVWLPK 350
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
371-468 |
3.15e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 79.80 E-value: 3.15e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 371 LKRCIGNLLDNALKYGERA-RLSLEDGPEAVALHVDDDGPGVPEQRLEQIFEPRFRL-SPRG-QGYGLGLGIARNIAHTH 447
Cdd:cd16950 1 LKRVLSNLVDNALRYGGGWvEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGdNARGtSGTGLGLAIVQRISDAH 80
|
90 100
....*....|....*....|.
gi 1544655203 448 GGEVSLQNRREGGLRVSLRLP 468
Cdd:cd16950 81 GGSLTLANRAGGGLCARIELP 101
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
259-469 |
6.35e-18 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 86.56 E-value: 6.35e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 259 TMHERIDRYLN--ER----GQLFSAISHDLRTPITRLRLRVELLEDERLQ---EKFG----RDLDELELLVKGALQCVKD 325
Cdd:PRK11360 372 TERKRLQRRVArqERlaalGELVAGVAHEIRNPLTAIRGYVQIWRQQTSDppsQEYLsvvlREVDRLNKVIDQLLEFSRP 451
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 326 TdiHENVEPVDLNLLLQHI---AEPYLADGRVEVVGRAAEPYPG---KPLALKRCIGNLLDNALK-YGERARLSLE---D 395
Cdd:PRK11360 452 R--ESQWQPVSLNALVEEVlqlFQTAGVQARVDFETELDNELPPiwaDPELLKQVLLNILINAVQaISARGKIRIRtwqY 529
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1544655203 396 GPEAVALHVDDDGPGVPEQRLEQIFEPRFrlSPRGQGYGLGLGIARNIAHTHGGEVSLQNRREGGLRVSLRLPR 469
Cdd:PRK11360 530 SDGQVAVSIEDNGCGIDPELLKKIFDPFF--TTKAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPI 601
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
241-468 |
1.33e-17 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 85.86 E-value: 1.33e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 241 ALEERGASELVEVARaFNTMHERIdrylneRGQLFSAISHDLRTPITRL------------------------------- 289
Cdd:PRK10490 641 ALERLTLTASEEQAR-LASEREQL------RNALLAALSHDLRTPLTVLfgqaeiltldlasegspharqaseirqqvln 713
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 290 --RLRVELLEDERLQEKfGRDLDE----LELLVKGALQCVKDTDIHENVE---PVDLNLLlqHIaepylaDGrvevvgra 360
Cdd:PRK10490 714 ttRLVNNLLDMARIQSG-GFNLRKewltLEEVVGSALQMLEPGLSGHPINlslPEPLTLI--HV------DG-------- 776
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 361 aepypgkPLaLKRCIGNLLDNALKY-GERARLSLEDGPEAVALHVD--DDGPGVPEQRLEQIFEpRFrlsPRGQ------ 431
Cdd:PRK10490 777 -------PL-FERVLINLLENAVKYaGAQAEIGIDAHVEGERLQLDvwDNGPGIPPGQEQLIFD-KF---ARGNkesaip 844
|
250 260 270
....*....|....*....|....*....|....*..
gi 1544655203 432 GYGLGLGIARNIAHTHGGEVSLQNRREGGLRVSLRLP 468
Cdd:PRK10490 845 GVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLP 881
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
368-461 |
1.51e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 77.89 E-value: 1.51e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 368 PLALKRCIGNLLDNALKY---GERARLSLEDGPEAVALHVDDDGPGVPEQRLEQIFEpRFRLSPRGQG----YGLGLGIA 440
Cdd:cd16945 2 PFLLRQAINNLLDNAIDFspeGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFE-RFYSLPRPHSgqksTGLGLAFV 80
|
90 100
....*....|....*....|.
gi 1544655203 441 RNIAHTHGGEVSLQNRREGGL 461
Cdd:cd16945 81 QEVAQLHGGRITLRNRPDGVL 101
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
259-468 |
1.65e-17 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 83.74 E-value: 1.65e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 259 TMHERIDRYLNER------GQLFSAISHDLRTPITRLRLRVELLE----DERLQEKFGRDLDE---LELLVKGALQCVKD 325
Cdd:COG3852 117 TERKRLERELRRAeklaavGELAAGLAHEIRNPLTGIRGAAQLLErelpDDELREYTQLIIEEadrLNNLVDRLLSFSRP 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 326 TDIHenVEPVDLNLLLQHIAEPYLAD--GRVEVVGRAAEPYP---GKPLALKRCIGNLLDNAL-------------KYGE 387
Cdd:COG3852 197 RPPE--REPVNLHEVLERVLELLRAEapKNIRIVRDYDPSLPevlGDPDQLIQVLLNLVRNAAeampeggtitirtRVER 274
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 388 RARLSLEDGPEAVALHVDDDGPGVPEQRLEQIFEPRFrlSPRGQGYGLGLGIARNIAHTHGGEVSLQNRREGGLRVSLRL 467
Cdd:COG3852 275 QVTLGGLRPRLYVRIEVIDNGPGIPEEILDRIFEPFF--TTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYL 352
|
.
gi 1544655203 468 P 468
Cdd:COG3852 353 P 353
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
371-468 |
5.61e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 76.35 E-value: 5.61e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 371 LKRCIGNLLDNALKY---GERARLSLEDGPEAVALHVDDDGPGVPEQRLEQIFEPRFRL-SPRGQ---GYGLGLGIARNI 443
Cdd:cd16946 5 LQQLFVNLLENSLRYtdtGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVeSSRNRasgGSGLGLAICHNI 84
|
90 100
....*....|....*....|....*
gi 1544655203 444 AHTHGGEVSLQNRREGGLRVSLRLP 468
Cdd:cd16946 85 ALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
221-471 |
1.66e-16 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 81.74 E-value: 1.66e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 221 RPLKRLARAARDLALGSPSAALE-ERGASELVEVARAFNTMHERIDRYLNeRGQLFSA-ISHDLRTPITRLRLRVEL-LE 297
Cdd:PRK09835 211 APIRSVSRQIQNITSKDLDVRLDpQTVPIELEQLVLSFNHMIERIEDVFT-RQSNFSAdIAHEIRTPITNLITQTEIaLS 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 298 DER----LQEKFGRDLDELELLVKGA-----LQCVKDTDIHENVEPVDLNLLLQHIAEPY--LADGR---VEVVGRAAEP 363
Cdd:PRK09835 290 QSRsqkeLEDVLYSNLEELTRMAKMVsdmlfLAQADNNQLIPEKKMLDLADEVGKVFDFFeaWAEERgveLRFVGDPCQV 369
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 364 YpGKPLALKRCIGNLLDNALKY---GERARLSLEDGPEAVALHVDDDGPGVPEQRLEQIFEPRFRLSP----RGQGYGLG 436
Cdd:PRK09835 370 A-GDPLMLRRAISNLLSNALRYtpaGEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPsrqrKGEGSGIG 448
|
250 260 270
....*....|....*....|....*....|....*
gi 1544655203 437 LGIARNIAHTHGGEVSLQNRREgGLRVSLRLPRLG 471
Cdd:PRK09835 449 LAIVKSIVVAHKGTVAVTSDAR-GTRFVISLPRLE 482
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
371-468 |
2.04e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 74.84 E-value: 2.04e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 371 LKRCIGNLLDNALKYGER-------ARLSLEDGPEAVALHVDDDGPGVPEQRLEQIFEPrF-----RLSPRGQGYGLGLG 438
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEgevtlrvSLEEEEEDGVQLRFSVEDTGIGIPEEQQARLFEP-FsqadsSTTRKYGGTGLGLA 79
|
90 100 110
....*....|....*....|....*....|
gi 1544655203 439 IARNIAHTHGGEVSLQNRREGGLRVSLRLP 468
Cdd:cd16922 80 ISKKLVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
375-469 |
3.94e-16 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 79.89 E-value: 3.94e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 375 IGNLLDNALKYGERA-------RLSLEDGPEAVALHVDDDGPGVPEQRLEQIFEPRFrLSPRGQGYGLGLGIARNIAHTH 447
Cdd:COG3290 286 LGNLLDNAIEAVEKLpeeerrvELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGF-STKLGEGRGLGLALVKQIVEKY 364
|
90 100
....*....|....*....|..
gi 1544655203 448 GGEVSLQNRREGGLRVSLRLPR 469
Cdd:COG3290 365 GGTIEVESEEGEGTVFTVRLPK 386
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
377-467 |
1.07e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 72.49 E-value: 1.07e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 377 NLLDNALKYGE-----RARLSLEDGPEAVALHVDDDGPGVPEQRLEQIFEPRFRLSPRGQGYGLGLGIARNIAHTHGGEV 451
Cdd:cd16976 7 NLLQNALDAMGkvenpRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVGKGTGLGLSISYGIVEEHGGRL 86
|
90
....*....|....*.
gi 1544655203 452 SLQNRREGGLRVSLRL 467
Cdd:cd16976 87 SVANEEGAGARFTFDL 102
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
273-451 |
1.75e-15 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 77.68 E-value: 1.75e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 273 QLFSAISHDLRTPITRLRLRVELLE--------------DERLQEKFGRDLDELELLVKGALQCVK--DTDIHENVEPVD 336
Cdd:PRK09303 153 RVLAMLAHDLRTPLTAASLALETLElgqidedtelkpalIEQLQDQARRQLEEIERLITDLLEVGRtrWEALRFNPQKLD 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 337 LNLLLQHIAEPY---LADGRVEVVGRAAEPYP---GKPLALKRCIGNLLDNALKY---GERARLSledgpeavALH---- 403
Cdd:PRK09303 233 LGSLCQEVILELekrWLAKSLEIQTDIPSDLPsvyADQERIRQVLLNLLDNAIKYtpeGGTITLS--------MLHrttq 304
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1544655203 404 -----VDDDGPGVPEQRLEQIFEPRFRLsPRGQ---GYGLGLGIARNIAHTHGGEV 451
Cdd:PRK09303 305 kvqvsICDTGPGIPEEEQERIFEDRVRL-PRDEgteGYGIGLSVCRRIVRVHYGQI 359
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
276-468 |
1.21e-14 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 76.48 E-value: 1.21e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 276 SAISHDLRTPITRLRLRVELLEDERLQEKFGRDLDELELLVKGALQCVKD-----------TDIHENVEPVDLNLLLQ-- 342
Cdd:PRK11466 449 AAMSHEIRTPLYGILGTAQLLADNPALNAQRDDLRAITDSGESLLTILNDildysaieaggKNVSVSDEPFEPRPLLEst 528
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 343 -HIAEPYLADGRVEVVGRAAEPYP----GKPLALKRCIGNLLDNALKYGERARLSLEDGPEAVA--LHVDDDGPGVPEQR 415
Cdd:PRK11466 529 lQLMSGRVKGRPIRLATDIADDLPtalmGDPRRIRQVITNLLSNALRFTDEGSIVLRSRTDGEQwlVEVEDSGCGIDPAK 608
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1544655203 416 LEQIFEPRFRLSPRGQGYGLGLGIARNIAHTHGGEVSLQNRREGGLRVSLRLP 468
Cdd:PRK11466 609 LAEIFQPFVQVSGKRGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLP 661
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
223-468 |
1.81e-14 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 76.22 E-value: 1.81e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 223 LKRLARAARDL--ALGSPSAALEERGASELVEVARAfntmhERIDRYLNERGQL-FSAISHDLRTPITRLRLRVELLEDE 299
Cdd:PRK15347 352 LGSIAKAYNQLldTLNEQYDTLENKVAERTQALAEA-----KQRAEQANKRKSEhLTTISHEIRTPLNGVLGALELLQNT 426
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 300 RLqekfgrDLDELELLvKGALQCVKDTDIHEN-------VEPVDLNLLLQHIAE-PYLADGRVEVVGRAAEpypgKPLAL 371
Cdd:PRK15347 427 PL------TAEQMDLA-DTARQCTLSLLAIINnlldfsrIESGQMTLSLEETALlPLLDQAMLTIQGPAQS----KSLTL 495
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 372 KRCIG-------------------NLLDNALKYGE--RARLSLEDGPEAVALHVDDDGPGVPEQRLEQIFEPRFRLSPRG 430
Cdd:PRK15347 496 RTFVGahvplylhldslrlrqilvNLLGNAVKFTEtgGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTHS 575
|
250 260 270
....*....|....*....|....*....|....*...
gi 1544655203 431 QGYGLGLGIARNIAHTHGGEVSLQNRREGGLRVSLRLP 468
Cdd:PRK15347 576 QGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLP 613
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
272-468 |
3.29e-14 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 74.44 E-value: 3.29e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 272 GQLFSAISHDLRTPITRLRLRVELL--------EDERLQEKFGRDLDELELLVKGALQCVKDTDIheNVEPVDLNLLLQH 343
Cdd:PRK10364 238 GHLAAGVAHEIRNPLSSIKGLAKYFaerapaggEAHQLAQVMAKEADRLNRVVSELLELVKPTHL--ALQAVDLNDLINH 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 344 IAEPYLADGR---VEVVGRAAEPYP---GKPLALKRCIGNLLDNALK-YGERARLSLE--DGPEAVALHVDDDGPGVPEQ 414
Cdd:PRK10364 316 SLQLVSQDANsreIQLRFTANDTLPeiqADPDRLTQVLLNLYLNAIQaIGQHGVISVTasESGAGVKISVTDSGKGIAAD 395
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1544655203 415 RLEQIFEPRFrlSPRGQGYGLGLGIARNIAHTHGGEVSLQNRREGGLRVSLRLP 468
Cdd:PRK10364 396 QLEAIFTPYF--TTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLP 447
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
368-469 |
4.98e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 67.83 E-value: 4.98e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 368 PLALKRCIGNLLDNALK-YGERARLSLEDGP--EAVALHVDDDGPGVPEQRLEQIFEPRFRLSPRGQGYGLGLGIARNIA 444
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQaMEGRGRITIRTWAhvDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGEGTGLGLSLSYRII 80
|
90 100
....*....|....*....|....*
gi 1544655203 445 HTHGGEVSLQNRREGGLRVSLRLPR 469
Cdd:cd16943 81 QKHGGTIRVASVPGGGTRFTIILPI 105
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
371-468 |
2.31e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 66.06 E-value: 2.31e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 371 LKRCIGNLLDNALKYG--ERARLSLEDGPEA--VALHVDDDGPGVPEQRLEQIFEPRFRLSPR----GQGYGLGLGIARN 442
Cdd:cd16953 1 LGQVLRNLIGNAISFSppDTGRITVSAMPTGkmVTISVEDEGPGIPQEKLESIFDRFYTERPAneafGQHSGLGLSISRQ 80
|
90 100 110
....*....|....*....|....*....|
gi 1544655203 443 IAHTHGGEVSLQNRREG----GLRVSLRLP 468
Cdd:cd16953 81 IIEAHGGISVAENHNQPgqviGARFTVQLP 110
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
262-468 |
5.22e-13 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 70.77 E-value: 5.22e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 262 ERIDRyLNERGQLFSAISHDLRTPITRLRLRVELLEDERLQEK---FG---RDLDELELLVKGALQCVKDTDIHenVEPV 335
Cdd:COG5809 262 RKSEK-LSVVGELAAGIAHEIRNPLTSLKGFIQLLKDTIDEEQktyLDimlSELDRIESIISEFLVLAKPQAIK--YEPK 338
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 336 DLNLLLQHIAEPYLADG---RVEVVGRAAEPYP---GKPLALKRCIGNLLDNALKY----GE-RARLSLEDgPEAVALHV 404
Cdd:COG5809 339 DLNTLIEEVIPLLQPQAllkNVQIELELEDDIPdilGDENQLKQVFINLLKNAIEAmpegGNiTIETKAED-DDKVVISV 417
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1544655203 405 DDDGPGVPEQRLEQIFEPRFrlSPRGQGYGLGLGIARNIAHTHGGEVSLQNRREGGLRVSLRLP 468
Cdd:COG5809 418 TDEGCGIPEERLKKLGEPFY--TTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLP 479
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
376-468 |
7.97e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 64.66 E-value: 7.97e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 376 GNLLDNALKY---GERARLSL--EDGPEAVALHVDDDGPGVPEQRLEQIFEPRFRLSPRGQ--GYGLGLGIARNIAHTHG 448
Cdd:cd16921 6 TNLLGNAIKFrrpRRPPRIEVgaEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSREEyeGTGVGLAIVRKIIERHG 85
|
90 100
....*....|....*....|
gi 1544655203 449 GEVSLQNRREGGLRVSLRLP 468
Cdd:cd16921 86 GRIWLESEPGEGTTFYFTLP 105
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
217-463 |
1.12e-12 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 69.66 E-value: 1.12e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 217 HWQSRPLKRLARAARDLALGSpSAALEERGASELVEVARAFNTM--HERiDRYLNERGQLfSAISHDLRTPITRLR--LR 292
Cdd:PRK10815 213 WWSLRPIEALAKQVRELEEGE-REQLDPNPPRELTSLVRNLNRLlkNER-ERYTKYRTTL-TDLTHSLKTPLAVLQstLR 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 293 vellederlqekfgrdldelellvkgALQCVKDTDIhENVEPVDL---NLLLQHIAEpYL--ADGRVE--VVGRAAEPYP 365
Cdd:PRK10815 290 --------------------------SLRSGKQMSV-EQAEPIMLeqiSRISQQIGY-YLhrASMRSEhnLLSRELHSVA 341
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 366 gkPL------ALKRC----------------------------IGNLLDNALKYG-ERARLSLEDGPEAVALHVDDDGPG 410
Cdd:PRK10815 342 --PLldnltsALNKVyqrkgvnitldispeitfvgekndfmevMGNVLDNACKYClEFVEISARQTDEHLHIVVEDDGPG 419
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 411 VPEQRLEQIFEprfrlspRGQ-------GYGLGLGIARNIAHTHGGEVSLQNRREGGLRV 463
Cdd:PRK10815 420 IPESKRELIFD-------RGQradtlrpGQGLGLSVAREITEQYEGKISAGDSPLGGARM 472
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
371-468 |
1.41e-12 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 64.05 E-value: 1.41e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 371 LKRCIGNLLDNALKY---GERARLSLE-DGPEAVALHVDDDGPGVPEQRLEQIFEpRFR--LSPRGQ---GYGLGLGIAR 441
Cdd:cd16925 5 YERVVLNLLSNAFKFtpdGGRIRCILEkFRLNRFLLTVSDSGPGIPPNLREEIFE-RFRqgDGSSTRahgGTGLGLSIVK 83
|
90 100
....*....|....*....|....*..
gi 1544655203 442 NIAHTHGGEVSLQNRREGGLRVSLRLP 468
Cdd:cd16925 84 EFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
370-456 |
1.86e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 64.07 E-value: 1.86e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 370 ALKRCIGNLLDNALKYGERAR---LSLEDGPEAVALHVDDDGPGVPEQRLEQIFEPRFRL----SPRGQGYGLGLGIARN 442
Cdd:cd16947 20 ALQRILKNLISNAIKYGSDGKflgMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLedsrNSAKQGNGLGLTITKR 99
|
90
....*....|....
gi 1544655203 443 IAHTHGGEVSLQNR 456
Cdd:cd16947 100 LAESMGGSIYVNSK 113
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
377-466 |
1.88e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 63.57 E-value: 1.88e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 377 NLLDNALK-----YGERARLSLE---DGPEAVALHVDDDGPGVPEQRLEQIFEPRFrlSPRGQGYGLGLGIARNIAHTHG 448
Cdd:cd16920 7 NLVRNGIEamsegGCERRELTIRtspADDRAVTISVKDTGPGIAEEVAGQLFDPFY--TTKSEGLGMGLSICRSIIEAHG 84
|
90 100
....*....|....*....|
gi 1544655203 449 GEVSLQNRREGG--LRVSLR 466
Cdd:cd16920 85 GRLSVESPAGGGatFQFTLP 104
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
375-468 |
2.89e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 63.08 E-value: 2.89e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 375 IGNLLDNAL-------KYGERARLSLEDGPEAVALHVDDDGPGVPEQRLEQIFEPRFRLSPRGqGYGLGLGIARNIAHTH 447
Cdd:cd16915 5 VGNLIDNALdalaatgAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQG-ERGIGLALVRQSVERL 83
|
90 100
....*....|....*....|.
gi 1544655203 448 GGEVSLQNRREGGLRVSLRLP 468
Cdd:cd16915 84 GGSITVESEPGGGTTFSIRIP 104
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
370-468 |
2.94e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 60.24 E-value: 2.94e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 370 ALKRCIGNLLDNALKYGERA-------RLSLEDG-PEAVALHVDDDGPGVPEQRLEQIFEPRfrLSPRGQGYGLGLGIAR 441
Cdd:cd16944 4 QISQVLTNILKNAAEAIEGRpsdvgevRIRVEADqDGRIVLIVCDNGKGFPREMRHRATEPY--VTTRPKGTGLGLAIVK 81
|
90 100
....*....|....*....|....*..
gi 1544655203 442 NIAHTHGGEVSLQNRREGGLRVSLRLP 468
Cdd:cd16944 82 KIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
268-468 |
3.50e-11 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 65.14 E-value: 3.50e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 268 LNERGQLFSAISHDLRTPITRLRLRVELLEDERL-QEKFGR----DLDELELLVKGALQCVKDTDIheNVEPVDLNLLLQ 342
Cdd:COG5805 284 LSIAGQLAAGIAHEIRNPLTSIKGFLQLLQPGIEdKEEYFDimlsELDRIESIISEFLALAKPQAV--NKEKENINELIQ 361
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 343 HI-----AEPYLADGRVEVVGRAAEPY-PGKPLALKRCIGNLLDNALKY---GERARLSLEDGPEAVALHVDDDGPGVPE 413
Cdd:COG5805 362 DVvtlleTEAILHNIQIRLELLDEDPFiYCDENQIKQVFINLIKNAIEAmpnGGTITIHTEEEDNSVIIRVIDEGIGIPE 441
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1544655203 414 QRLEQIFEPRFrlSPRGQGYGLGLGIARNIAHTHGGEVSLQNRREGGLRVSLRLP 468
Cdd:COG5805 442 ERLKKLGEPFF--TTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLP 494
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
369-466 |
9.71e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 58.63 E-value: 9.71e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 369 LALKRCIGNLLDNALKY---GERARLSLEDGPEAVALHVDDDGPGVPEQRLEQIFEPRFR---LSPRGQGYGLGLGIARN 442
Cdd:cd16975 3 LLLSRALINIISNACQYapeGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRddtSRRSGGHYGMGLYIAKN 82
|
90 100
....*....|....*....|....
gi 1544655203 443 IAHTHGGEVSLQNRREGGLRVSLR 466
Cdd:cd16975 83 LVEKHGGSLIIENSQKGGAEVTVK 106
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
162-469 |
1.43e-10 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 63.11 E-value: 1.43e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 162 VLVTQIRIGDSEWlYIASLMPAPYVSLEPEGLQPQQVLSIVFTSLLLLLFTGLLMHWQSRPLKRLARAARDLALGSpSAA 241
Cdd:COG2972 125 LLIILLLLSLLGW-TLVSLIPKSELFRGLFSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGD-LVR 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 242 LEERGASELVEVARAFNTMHERIDRYLNERGQLFSAIS-------------HDLRTPITRLRLRVELLEDERLQEKfgrd 308
Cdd:COG2972 203 LEVSGNDEIGILARSFNEMVERIKELIEEVYELELEKKeaelkalqaqinpHFLFNTLNSIRWLAELEDPEEAEEM---- 278
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 309 LDELELLVKGALQCVKDTD-IHENVEPVDLNLLLQHIaepyLADGRVEVVgRAAEPYPGKPLALKRCIGNLLDNALKYGE 387
Cdd:COG2972 279 LEALSKLLRYSLSKGDELVtLEEELELIKSYLEIQKL----RFGDRLEVE-IEIDEELLDLLIPKLILQPLVENAIEHGI 353
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 388 RA-------RLSLEDGPEAVALHVDDDGPGVPEQRLEQIFEprfRLSPRGQGYGLGLGIARN-IAHTHGGE--VSLQNRR 457
Cdd:COG2972 354 EPkegggtiRISIRKEGDRLVITVEDNGVGMPEEKLEKLLE---ELSSKGEGRGIGLRNVRErLKLYYGEEygLEIESEP 430
|
330
....*....|..
gi 1544655203 458 EGGLRVSLRLPR 469
Cdd:COG2972 431 GEGTTVTIRIPL 442
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
249-468 |
2.04e-10 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 62.34 E-value: 2.04e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 249 ELVEVARAFNTMHEridrYLNERGQLFSAISHDLRTPITRLRLRVELLEDE----RLQEKFGRDLDE----LELLVKGAL 320
Cdd:PRK11006 186 QLLMVARDVTQMHQ----LEGARRNFFANVSHELRTPLTVLQGYLEMMQDQplegALREKALHTMREqtqrMEGLVKQLL 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 321 QCVK-----DTDIHENVEPVDLNLLLQHIAEPyLADGRVEVVGRAAEPYP--GKPLALKRCIGNLLDNALKY---GERAR 390
Cdd:PRK11006 262 TLSKieaapTIDLNEKVDVPMMLRVLEREAQT-LSQGKHTITFEVDNSLKvfGNEDQLRSAISNLVYNAVNHtpeGTHIT 340
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 391 LSLEDGPEAVALHVDDDGPGVPEQRLEQIFEPRFRL----SPRGQGYGLGLGIARNIAHTHGGEVSLQNRREGGLRVSLR 466
Cdd:PRK11006 341 VRWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVdkarSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFV 420
|
..
gi 1544655203 467 LP 468
Cdd:PRK11006 421 LP 422
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
386-465 |
4.67e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 56.64 E-value: 4.67e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 386 GERARLSLEdgpeavaLHVDDDGPGVPEQRLEQIFEPrfRLSPRGQGYGLGLGIARNIAHTHGGEVSLQNR-REGGLRVS 464
Cdd:cd16918 37 HPRHRLALR-------VSVIDNGPGIPPDLQDTIFYP--MVSGRENGTGLGLAIAQNIVSQHGGVIECDSQpGHTVFSVS 107
|
.
gi 1544655203 465 L 465
Cdd:cd16918 108 L 108
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
371-452 |
1.20e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 55.47 E-value: 1.20e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 371 LKRCIGNLLDNALKYGE---RARLSLEDGPEAVALHVDDDGPGVPEQRLEQIFEPRFRL--SPRGQGYGLGLGIARNIAH 445
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPentRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGdnSRNTEGAGLGLSIAKAIIE 80
|
....*..
gi 1544655203 446 THGGEVS 452
Cdd:cd16923 81 LHGGSAS 87
|
|
| nifL_nitrog |
TIGR02938 |
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation ... |
271-468 |
1.79e-09 |
|
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions]
Pssm-ID: 131984 [Multi-domain] Cd Length: 494 Bit Score: 59.92 E-value: 1.79e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 271 RGQLFSAIsHDLRTPITRLRLRVELLEdeRLQEKFGRD--LDELELLVKGAL-------QCVKDTDiHENVEPVDLNLLL 341
Cdd:TIGR02938 277 RETLSAAI-HRLQGPMNLISAAISVLQ--RRGDDAGNPasAAMLQQALSAGRehmealrQVIPQSP-QEIVVPVNLNQIL 352
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 342 QHI----AEPYLADG-RVEVVGRAAEPY-PGKPLALKRCIGNLLDNAL-----KYGERARLSLEDGPEAVALHVD--DDG 408
Cdd:TIGR02938 353 RDVitlsTPRLLAAGiVVDWQPAATLPAiLGRELQLRSLFKALVDNAIeamniKGWKRRELSITTALNGDLIVVSilDSG 432
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1544655203 409 PGVPEQRLEQIFEPRFRL-SPRGQGYGLGLGIARNIAHTHGGEVSLQNRREGGLRVSLRLP 468
Cdd:TIGR02938 433 PGIPQDLRYKVFEPFFTTkGGSRKHIGMGLSVAQEIVADHGGIIDLDDDYSEGCRIIVEFR 493
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
286-469 |
2.66e-09 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 57.71 E-value: 2.66e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 286 ITRLRLRVELLED--ERLQEKFGRDLDELELLVKGALQCVKDT--DIH-ENVEPVDLNLLLQHIAEPYLADG----RVEV 356
Cdd:COG4585 69 LSAIKLQLEAARRllDADPEAAREELEEIRELAREALAELRRLvrGLRpPALDDLGLAAALEELAERLLRAAgirvELDV 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 357 VGRAAEPYPGKPLALKRCIGNLLDNALKYGE--RARLSLEDGPEAVALHVDDDGPGVPEQRleqifeprfrlsPRGQGYG 434
Cdd:COG4585 149 DGDPDRLPPEVELALYRIVQEALTNALKHAGatRVTVTLEVDDGELTLTVRDDGVGFDPEA------------APGGGLG 216
|
170 180 190
....*....|....*....|....*....|....*
gi 1544655203 435 LgLGIaRNIAHTHGGEVSLQNRREGGLRVSLRLPR 469
Cdd:COG4585 217 L-RGM-RERAEALGGTLTIGSAPGGGTRVRATLPL 249
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
375-468 |
3.20e-08 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 55.69 E-value: 3.20e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 375 IGNLLDNALKygerARLSLEDGPEAVALH---------VDDDGPGVPEQRLEQIFEPRFrlSPRGQGYGLGLGIARNIAH 445
Cdd:PRK11086 438 LGNLIENALE----AVGGEEGGEISVSLHyrngwlhceVSDDGPGIAPDEIDAIFDKGY--STKGSNRGVGLYLVKQSVE 511
|
90 100
....*....|....*....|...
gi 1544655203 446 THGGEVSLQNRREGGLRVSLRLP 468
Cdd:PRK11086 512 NLGGSIAVESEPGVGTQFFVQIP 534
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
331-469 |
3.25e-08 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 56.22 E-value: 3.25e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 331 NVEPVDLNLLLQHIAePYLA---DGRVEV-VGRAAEPY--PGKPLALKRCIGNLLDNALK-YGERAR----LSLEDGP-- 397
Cdd:PRK13837 516 NTKPFDLSELVTEIA-PLLRvslPPGVELdFDQDQEPAvvEGNPAELQQVLMNLCSNAAQaMDGAGRvdisLSRAKLRap 594
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 398 -----------EAVALHVDDDGPGVPEQRLEQIFEPRFrlSPRGQGYGLGLGIARNIAHTHGGEVSLQNRREGGLRVSLR 466
Cdd:PRK13837 595 kvlshgvlppgRYVLLRVSDTGAGIDEAVLPHIFEPFF--TTRAGGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVY 672
|
...
gi 1544655203 467 LPR 469
Cdd:PRK13837 673 LPP 675
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
220-264 |
3.84e-08 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 49.37 E-value: 3.84e-08
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1544655203 220 SRPLKRLARAARDLALGSPSAALEERGASELVEVARAFNTMHERI 264
Cdd:cd06225 1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
271-468 |
4.29e-08 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 55.90 E-value: 4.29e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 271 RGQLFSAISHDLRTPITRLRLRVELLEDERLQEKfgRDLDELELL------VKGALQCVKDTDIHEN----VEP--VDLN 338
Cdd:PRK09959 712 KSQFLATMSHEIRTPISSIMGFLELLSGSGLSKE--QRVEAISLAyatgqsLLGLIGEILDVDKIESgnyqLQPqwVDIP 789
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 339 LLLQHIAEPYLADGRVEVVGRA-AEPYPG------KPLALKRCIGNLLDNALKYGERARLS-------LEDGPEAVALHV 404
Cdd:PRK09959 790 TLVQNTCHSFGAIAASKSIALScSSTFPDhylvkiDPQAFKQVLSNLLSNALKFTTEGAVKittslghIDDNHAVIKMTI 869
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1544655203 405 DDDGPGVPEQRLEQIFEpRFRLSPRGQ---GYGLGLGIARNIAHTHGGEVSLQNRREGGLRVSLRLP 468
Cdd:PRK09959 870 MDSGSGLSQEEQQQLFK-RYSQTSAGRqqtGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIP 935
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
400-468 |
9.99e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 50.46 E-value: 9.99e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1544655203 400 VALHVDDDGPGVPEQRLEQIFEPRFRLSPRGQGYGLGLGIARNIAHTHGGEVSLQNRREGGLRVSLRLP 468
Cdd:cd16919 48 VCLEVSDTGSGMPAEVLRRAFEPFFTTKEVGKGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| HAMP |
pfam00672 |
HAMP domain; |
216-264 |
1.55e-07 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 48.00 E-value: 1.55e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1544655203 216 MHWQSRPLKRLARAARDLALGSPSAALEERGASELVEVARAFNTMHERI 264
Cdd:pfam00672 3 ARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERL 51
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
217-269 |
1.80e-07 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 47.63 E-value: 1.80e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1544655203 217 HWQSRPLKRLARAARDLALGSPSAALEERGASELVEVARAFNTMHERIDRYLN 269
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
270-313 |
2.63e-07 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 47.59 E-value: 2.63e-07
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 1544655203 270 ERGQLFSAISHDLRTPITRLRLRVELLEDERLQEKFGRDLDELE 313
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQREYLETIL 44
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
373-468 |
2.74e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 48.32 E-value: 2.74e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 373 RCIGNLLDNALKY--GERARLSLEDGPEAVALHVDDDGPGvpeqrleqifeprFRLSPRGQGYGLGLGIARNIAHTHGGE 450
Cdd:cd16917 3 RIVQEALTNALKHagASRVRVTLSYTADELTLTVVDDGVG-------------FDGPAPPGGGGFGLLGMRERAELLGGT 69
|
90
....*....|....*...
gi 1544655203 451 VSLQNRREGGLRVSLRLP 468
Cdd:cd16917 70 LTIGSRPGGGTRVTARLP 87
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
270-313 |
1.18e-06 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 45.63 E-value: 1.18e-06
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 1544655203 270 ERGQLFSAISHDLRTPITRLRLRVELLEDERLQEKFGRDLDELE 313
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQREYLETIL 44
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
268-309 |
5.97e-06 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 43.74 E-value: 5.97e-06
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 1544655203 268 LNERGQLFSAISHDLRTPITRLRLRVELLEDERLQEKFGRDL 309
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREY 42
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
371-468 |
1.05e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 44.50 E-value: 1.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 371 LKRCIGNLLDNALKY---GERARLSLEDGPEAVALHVDDDGPGVPEQRLEQIFEPRFRLSPRGQ----GYGLGLGIARNI 443
Cdd:cd16952 1 LRSAFSNLVSNAVKYtppSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCrntgGTGLGLAIVKHV 80
|
90 100
....*....|....*....|....*
gi 1544655203 444 AHTHGGEVSLQNRREGGLRVSLRLP 468
Cdd:cd16952 81 MSRHDARLLIASELGKGSRFTCLFP 105
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
385-451 |
1.11e-05 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 47.38 E-value: 1.11e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1544655203 385 YGERARLsledgpeAVALHVDDDGPGVPEQRLEQIFEPRfrLSPRGQGYGLGLGIARNIAHTHGGEV 451
Cdd:PRK11073 273 HGERYRL-------AARIDIEDNGPGIPPHLQDTLFYPM--VSGREGGTGLGLSIARNLIDQHSGKI 330
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
371-468 |
1.87e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 43.81 E-value: 1.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 371 LKRCIGNLLDNALKY---GERARLSLEDGPEAVALHVDDDGPGVPEQRLEQIFEPRF-----RLSprGQGYGLGLGIARN 442
Cdd:cd16948 6 LSFIIGQIVSNALKYskqGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFtgengRNF--QESTGMGLYLVKK 83
|
90 100
....*....|....*....|....*.
gi 1544655203 443 IAHTHGGEVSLQNRREGGLRVSLRLP 468
Cdd:cd16948 84 LCDKLGHKIDVESEVGEGTTFTITFP 109
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
366-468 |
6.97e-05 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 45.35 E-value: 6.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 366 GKPLALKRCIGNLLDNALKYGERARLSLE---DGpEAVALHVDDDGPGVPEQRLEQIFEPRFRLSPRG----QGYGLGLG 438
Cdd:PRK10841 558 GDPMRLQQVISNLLSNAIKFTDTGCIVLHvrvDG-DYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVqrnfQGTGLGLA 636
|
90 100 110
....*....|....*....|....*....|
gi 1544655203 439 IARNIAHTHGGEVSLQNRREGGLRVSLRLP 468
Cdd:PRK10841 637 ICEKLINMMDGDISVDSEPGMGSQFTIRIP 666
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
400-468 |
7.03e-05 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 45.05 E-value: 7.03e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1544655203 400 VALHVDDDGPGVPEQRLEQIFEPRFRLSPRGQGYGLGLGIARNIAHTHGGEVSLQNRREGGLRVSLRLP 468
Cdd:PRK13557 325 VSIAVTDTGSGMPPEILARVMDPFFTTKEEGKGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFP 393
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
330-468 |
1.98e-04 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 43.74 E-value: 1.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 330 ENVEPVDLNLLLQHIAEPYLA-----DGRVEVVGRAAEPYPGK--PLALkrCIGNLLDNALKYGERA------RLSLEDG 396
Cdd:COG3920 354 EDWEGVDLRDYLRELLEPLRDsyggrGIRIELDGPDVELPADAavPLGL--ILNELVTNALKHAFLSgeggriRVSWRRE 431
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1544655203 397 PEAVALHVDDDGPGVPEQrleqiFEPrfrlsPRGQgyGLGLGIARNIAHTHGGEVSLqnRREGGLRVSLRLP 468
Cdd:COG3920 432 DGRLRLTVSDNGVGLPED-----VDP-----PARK--GLGLRLIRALVRQLGGTLEL--DRPEGTRVRITFP 489
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
375-469 |
5.86e-04 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 42.13 E-value: 5.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 375 IGNLLDNALKYGERAR-------LSLEDGPEAVALHVDDDGPGVPEQRLEQIFEP--RFRLSPRGQgYGLGLGIARNIAH 445
Cdd:PRK15053 437 VGNLLDNAFEASLRSDegnkiveLFLSDEGDDVVIEVADQGCGVPESLRDKIFEQgvSTRADEPGE-HGIGLYLIASYVT 515
|
90 100
....*....|....*....|....
gi 1544655203 446 THGGEVSLQNRREGGLRVSLRLPR 469
Cdd:PRK15053 516 RCGGVITLEDNDPCGTLFSIFIPK 539
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
366-460 |
7.63e-04 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 42.14 E-value: 7.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 366 GKPLALKRCIGNLLDNALKYGERA----RLSLEDGP-EAVALHVD--DDGPGVPEQRLEQIFEPrFR-----LSPRGQGY 433
Cdd:PRK11107 404 GDPLRLQQIITNLVGNAIKFTESGnidiLVELRALSnTKVQLEVQirDTGIGISERQQSQLFQA-FRqadasISRRHGGT 482
|
90 100
....*....|....*....|....*..
gi 1544655203 434 GLGLGIARNIAHTHGGEVSLQNRREGG 460
Cdd:PRK11107 483 GLGLVITQKLVNEMGGDISFHSQPNRG 509
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
220-473 |
1.68e-03 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 40.87 E-value: 1.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 220 SRPLKRLARAARDLALGSPSAALEERGASELVEVARAFNTMHERIDRYLNER-------GQLFSAISHDLRTPITRLRLR 292
Cdd:COG2770 237 TRPLRRLAEAARRIAAGDLDVRIPVSRKDEIGELARAFNRMADSLRESIEEAeeeeelaEAELARLLEALLELLLALLLL 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 293 VELLEDERLQEKFGRDLDELELLVKGALQCVKDTDIHENVEPVDLNLLLQHIAEPYLADGRVEVVGRAAEPYPGKPLALK 372
Cdd:COG2770 317 LLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAELLVLLALEALALEAELAAVLALLA 396
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 373 RCIGNLLDNALKYGERARLSLEDGPEAVALHVDDDGPGVPEQRLEQIFEPRFRLSPRGQGYGLGLGIARNIAHTHGGEVS 452
Cdd:COG2770 397 ALAAALLLLELALEELVLALLALALLALAAAAAAAEAAAAALELAAAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLA 476
|
250 260
....*....|....*....|.
gi 1544655203 453 LQNRREGGLRVSLRLPRLGLE 473
Cdd:COG2770 477 ALLLLAALGALELLLLEEEEE 497
|
|
| HATPase_TopVIB-like |
cd16933 |
Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family ... |
364-440 |
4.84e-03 |
|
Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family includes the histidine kinase-like ATPase (HATPase) domain of the B subunit of topoisomerase VI (Topo VIB). Topo VI is a heterotetrameric complex composed of two TopVIA and two TopVIB subunits and is categorized as a type II B DNA topoisomerase. It is found in archaea and also in plants. Type II enzymes cleave both strands of a DNA duplex and pass a second duplex through the resulting break in an ATP-dependent mechanism. DNA cleavage by Topo VI generates two-nucleotide 5'-protruding ends.
Pssm-ID: 340410 [Multi-domain] Cd Length: 203 Bit Score: 38.48 E-value: 4.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 364 YPGKPLALKRCIGNLLDNALKYGERA------RLSLED-GPEAVALHVDDDGPGVPEQRLEQIF-----EPRFRL-SPRG 430
Cdd:cd16933 13 FDNPIRSLYTTVRELVENSLDATEEAgilpdiKVEIEEiGKDHYKVIVEDNGPGIPEEQIPKVFgkvlyGSKYHNkQSRG 92
|
90
....*....|
gi 1544655203 431 QgYGLGLGIA 440
Cdd:cd16933 93 Q-QGLGISAA 101
|
|
| HATPase_PDK-like |
cd16929 |
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ... |
348-468 |
6.53e-03 |
|
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.
Pssm-ID: 340406 [Multi-domain] Cd Length: 169 Bit Score: 37.32 E-value: 6.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1544655203 348 YLADGRVEVVGRAAEPYPGKPLALKRCIGNLLDNAL----KYGERARLSLED-------GPEAVALHVDDDGPGVPEQRL 416
Cdd:cd16929 21 YLSSPELEIEGDPSIRFPYVPSHLYYILFELLKNAMratvESHGDDSDDLPPikvtvakGDEDLTIKISDRGGGIPREDL 100
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1544655203 417 EQIF------------EPRFRLSPRGQ-----GYGLGLGIARNIAHTHGGEVSLQNRREGGLRVSLRLP 468
Cdd:cd16929 101 ARLFsymystapqpslDDFSDLISGTQpsplaGFGYGLPMSRLYAEYFGGDLDLQSMEGYGTDVYIYLK 169
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
220-264 |
9.88e-03 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 38.46 E-value: 9.88e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1544655203 220 SRPLKRLARAARDLALGSPSAALEERGASELVEVARAFNTMHERI 264
Cdd:COG0840 207 TRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENL 251
|
|
| |
