|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
129-557 |
2.80e-144 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 422.37 E-value: 2.80e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 129 TMVVASTCFVVALASSIITADLIGVEEEFNVSEEVALVSITVFVMGFGIGPMMFAPLSEVVGRRWIYGVTLFLAVIFIIP 208
Cdd:cd17323 1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 209 CAVAQNIETLLICRALDGIWFSAPMTLVGGTLADLWRTEERGVPMAAFSAAPFIGPAIGPLIGGFLSDAAGWRWLYYIQI 288
Cdd:cd17323 81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 289 IFAFIVWILITFTVPetyaptilarrakkmreqtgeqehvteqdldlrpfaerlriflirpfqllfgelIVFLISLYMSV 368
Cdd:cd17323 161 IISGFCLILIFLFLP------------------------------------------------------IVLLLGLYVGL 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 369 LYGLLYMFFVAFPIVYQEGKGYSAGTTGLMFIPLALGVIASALCAPIVNRNYMTQ-VRKYNGHPPAEVRLIPMMCSCWFI 447
Cdd:cd17323 187 VYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRlKKKNGGKPEPEARLPPAFIGAFLF 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 448 PIGLFIFAWTSYPHLHWIGPAIGGFPVGFGFIFLYNAANNYLVDSYQHQAASALAAKTFLRSFWGAAVVLFTEQMYARLG 527
Cdd:cd17323 267 PIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLFAQPMFNNLG 346
|
410 420 430
....*....|....*....|....*....|
gi 154295116 528 YQWASSLLGFIALACCAIPFVFWVWGAKIR 557
Cdd:cd17323 347 VGWAFTLLAFISLAMIPIPFIFYKYGKKIR 376
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
121-503 |
4.24e-39 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 146.66 E-value: 4.24e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 121 SKAFKWYITMVVASTCFVVALASSIITADLIGVEEEFNVSEEVALVSITVFVMGFGIGPMMFAPLSEVVGRRWIYGVTLF 200
Cdd:COG2814 4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 201 LAVIFIIPCAVAQNIETLLICRALDGIWFSAPMTLVGGTLADLWRTEERGVPMAAFSAAPFIGPAIGPLIGGFLSDAAGW 280
Cdd:COG2814 84 LFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 281 RWLYYIQIIFAFIVWILITFTVPETYAPTilarrakkmreqtgeqehvteqdldlrpfaerlRIFLIRPFQLLFGELIVF 360
Cdd:COG2814 164 RWVFLVNAVLALLALLLLLRLLPESRPAA---------------------------------RARLRGSLRELLRRPRLL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 361 LISLYMSVLYGLLYMFFVAFPIVYQEGKGYSAGTTGLMFIPLALGVIASALCAPIVnrnymtqVRKYNghppaevRLIPM 440
Cdd:COG2814 211 LLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRL-------ADRFG-------RRRLL 276
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 154295116 441 MCSCWFIPIGLFIFAWTSyphlHWIGPAIGGFPVGFGFIFLYNAANNYLVDSYQHQAASALAA 503
Cdd:COG2814 277 LIGLLLLALGLLLLALAG----SLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASG 335
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
137-552 |
5.22e-36 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 138.86 E-value: 5.22e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 137 FVVALASSIITADLIGVEEEFNVSEEVALVSITVFVMGFGIGPMMFAPLSEVVGRRWIYGVTLFLAVIFIIPCAVAQNIE 216
Cdd:cd17320 9 ALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIE 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 217 TLLICRALDGIWFSAPMTLVGGTLADLWRTEERGVPMAAFSAAPFIGPAIGPLIGGFLSDAAGWRWLYYIQIIFAFIVWI 296
Cdd:cd17320 89 QLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 297 LITFTVPETYAPtilarrakkmreqtgeqehvteqdldlrPFAERLRIFLIRPFQLLFGELIVFLISLYMSVLYGLLYMF 376
Cdd:cd17320 169 LVLLFLPETLPE----------------------------EKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAY 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 377 FVAFPIVYQEGKGYSAGTTGLMFIPLALGVIASALCAPivnrnymTQVRKYNGHPPAEVRLIPMMCSCwfipIGLFIFAW 456
Cdd:cd17320 221 LAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNG-------RLVRRFGPRRLLRLGLLLLLAAA----LVLLLAAL 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 457 TSYPHLHWIgpAIGGFPVGFGFIFLYNAANNYLVDSYQHQAASALAAKTFLRSFWGAAVVLFTEQMYArlGYQWAsslLG 536
Cdd:cd17320 290 LGGLSLWPL--VAPLFLIFFGFGLIFPNATSLALEPFPHVAGTASALLGFLQFLIGALAGALVGLLPN--GTALP---MG 362
|
410
....*....|....*.
gi 154295116 537 FIALACCAIPFVFWVW 552
Cdd:cd17320 363 LLILVLGLLALLLLIL 378
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
137-514 |
8.74e-35 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 134.47 E-value: 8.74e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 137 FVVALASSIITADL-IGVEEEFNVSEEVALVSITVFVMGFGIGPMMFAPLSEVVGRRWIYGVTLFLAVIFIIPCAVAQNI 215
Cdd:pfam07690 6 FLAALGRSLLGPALpLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 216 ETLLICRALDGIWFSAPMTLVGGTLADLWRTEERGVPMAAFSAAPFIGPAIGPLIGGFLSDAAGWRWLYYIQIIFAFIVW 295
Cdd:pfam07690 86 WLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 296 ILITFTVPETYAPTILARRAKKMreqtgeqehvteqdldlrPFAERLRIFLIRPFQLLFgelivflislYMSVLYGLLYM 375
Cdd:pfam07690 166 VLLLLPRPPPESKRPKPAEEARL------------------SLIVAWKALLRDPVLWLL----------LALLLFGFAFF 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 376 FFVAFPIVYQEGKGYSAGTTGLMFIPLALGVIASALCAPIVNRNYmtqvrkynghpPAEVRLIPMMCSCWFIPIGLFIFA 455
Cdd:pfam07690 218 GLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRL-----------GRRRRLLLALLLLILAALGLLLLS 286
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 456 WTSYPHLHWIGPAIggfpVGFGFIFLYNAANNYLVDSY-QHQAASALAAKTFLRSFWGAA 514
Cdd:pfam07690 287 LTLSSLWLLLALLL----LGFGFGLVFPALNALVSDLApKEERGTASGLYNTAGSLGGAL 342
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
136-533 |
8.01e-31 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 124.23 E-value: 8.01e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 136 CFVVALASSIITADLIGVEEEFNVSEEVALVSITVFVMGFGIGPMMFAPLSEVVGRRWIYGVTLFLAVIFIIPCAVAQNI 215
Cdd:cd17503 5 AFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 216 ETLLICRALDGIwFSAPMTLVG-GTLADLWRTEERGVPMAAFSAAPFIGPAIGPLIGGFLSDAAGWRWLYYIQIIFAFIV 294
Cdd:cd17503 85 ASLIIFRILQGF-GGGVLIPLAqTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 295 WILITFtvpetyaptilarrakkmreqtgeqehvteqdLDLRPFAERlriflirpfQLLFGELIVFLISLymsVLYGLLY 374
Cdd:cd17503 164 LLLAPL--------------------------------LDLRLFKDR---------NFTLGLLLSFLLGL---GLFGAMF 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 375 MffvaFPIVYQEGKGYSAGTTGLMFIPLAlgvIASALCAPIVNRNYmtqvRKYNGHPPAevrLIPMMCSCWFIPIGLFIF 454
Cdd:cd17503 200 L----LPLYLQNVLGYSAFESGLVLAPGG---LASAILSPLVGRLL----DKFGPRLLL---LAGLLLLALGTLLLAFLT 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 455 AWTSYPHLHWIGpAIGGFPVGFGFIFLYNAANNYLVDsyqHQAASALAAKTFLRSFWGA-AVVLFTEQMYARLGYQWASS 533
Cdd:cd17503 266 PDTSLWLIILPL-FIRGLGMGLVFMPLNTLALNSLPP---EQIGDATALFNTIRQLGGSiGTALLATLLTNRTQFHHSRL 341
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
169-305 |
1.56e-30 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 116.21 E-value: 1.56e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 169 TVFVMGFGIGPMMFAPLSEV----VGRRWIYGVTLFLAVIFIIPCAVAQNIETLLICRALDGIWFSAPMTLVGGTLADLW 244
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLltdrFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 154295116 245 RTEERGVPMAAFSAAPFIGPAIGPLIGGFLSDAAGWRWLYYIQIIFAFIVWILITFTVPET 305
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
137-552 |
1.39e-27 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 113.81 E-value: 1.39e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 137 FVVALASSIITADLIGVEEEFNVSEEVALVsITVFVMGFGIGPMMFAPLSEVVGRRWIYgvtLFLAVIFIIP---CAVAQ 213
Cdd:cd17502 6 FLAALDQTIVATALPTIVAEFGGLSLVSWV-GTAYLLTSTAFQPIYGKLSDLFGRKWVL---LIAIVIFELGsllCGLAP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 214 NIETLLICRALDGIWFSAPMTLVGGTLADLWRTEERGVPMAAFSAAPFIGPAIGPLIGGFLSDAAGWRWLYYIQIIFAfi 293
Cdd:cd17502 82 NMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIG-- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 294 vwilitftvpetyaptILArrakkmreqtgeqehvteqdldlrpfaerlrIFLIRPFqllfgelivFLISLYMSVLYGLL 373
Cdd:cd17502 160 ----------------GLA-------------------------------LALLRTI---------LLSSIFGFLFGGAL 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 374 YMFFVAFPIVYQEGKGYSAGTTGLMFIPLALGVIASALCAPIVNRNYmtqvrkynghppaeVRLIPMMCSCWFIP-IGLF 452
Cdd:cd17502 184 FGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKT--------------GRYKPLIVIGTILMsVGAG 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 453 IFAWTSY--PHLHWIG-PAIGGFPVGFGFIFLYNAANNYLVdsyQHQAASALAAKTFLRSFWGAAVVLFTeqmyarlgyq 529
Cdd:cd17502 250 LLTTLTLdtSKWLLIGyLILLGLGLGIGFQQPLVAVQNAVP---PADVGVATATNTFFRSLGGTLGVAIT---------- 316
|
410 420
....*....|....*....|...
gi 154295116 530 wassLLGFIALACCAIPFVFWVW 552
Cdd:cd17502 317 ----DVFLVALALAALAFLLSLF 335
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
137-541 |
2.63e-27 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 113.81 E-value: 2.63e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 137 FVVALASSIITADLIGVEEEFNVSEEVALVSITVFVMGFGIGPMMFAPLSEVVGRRWIY--GVTLFLAVIFIipCAVAQN 214
Cdd:cd17321 6 FLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFliGLALFGLASLL--CALAPS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 215 IETLLICRALDGIWFSAPMTLVGGTLADLWRTEERGVPMAAFSAAPFIGPAIGPLIGGFLSDAAGWRWLYYIQIIFAFIV 294
Cdd:cd17321 84 LAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 295 WilitftvpetyaptILARRakkmreqtgeqehvteqdldlrpfaerlriflirpfqllfgelivFLISLYMSVLYGLLY 374
Cdd:cd17321 164 L--------------LLART---------------------------------------------FSGAVLAAFLLGAAL 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 375 M-FFVAFPIVYQEGKGYSAGTTGLMFIPLALGVIASALCAPIVnrnymtqVRKYNGhppaevrLIPMMCSCWFIPIGLFI 453
Cdd:cd17321 185 GgLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRL-------ADRFGP-------RLVLVAGLLLTAVGLLL 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 454 FAWTsyPHLHWIGPAIGGFPV-GFGFIFLYNAANNYLVDSY-QHQAASALAAKTFLRSFWGA-----AVVLFTEQMYARL 526
Cdd:cd17321 251 LALL--GADSSVWLLLPGLVLlGLGLGLFATPLTNAALSSVpKEKAGAASGILNTARQLGGAlgvalLGALLTAGLSANL 328
|
410
....*....|....*
gi 154295116 527 GYQWASSLLGFIALA 541
Cdd:cd17321 329 GDSGVAALLSAAAAA 343
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
125-410 |
1.95e-26 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 109.52 E-value: 1.95e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 125 KWYITMVVASTCFVVALASSIITADLIGVEEEFNVSEEVALVSITVFVMGFGIGPMMFAPLSEVVGRRWIYGVTLFLAVI 204
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 205 FIIPCAVAQNIETLLICRALDGIwfSAPMTLVGGT--LADLWRTEERGVPMAAFSAAPFIGPAIGPLIGGFLSDAAGWRW 282
Cdd:COG0477 92 ASLLCGLAPSPELLIAARALQGI--GAGGLMPGALalIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRW 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 283 LYYIQIIFAfIVWILITFTVPETYAPTILARRAKKMREQTGEQEHVTEQdLDLRPFAERLRIFLIRPFQLLFGELIVFLI 362
Cdd:COG0477 170 IFLINAPLG-LLALVLRLRLPESRGLLLALLALALAALLLAALALALLA-LLLLLLLLLLALLALLLAGAALLLLLALLL 247
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 154295116 363 SLYMSVLYGLLYMFFVAFPIVYQEGKGYSAGTTGLMFIPLALGVIASA 410
Cdd:COG0477 248 LALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
170-551 |
4.03e-26 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 110.36 E-value: 4.03e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 170 VFVMGFGIGPMMFAP----LSEVVGRRWIYGVTLFLAVIFIIPCAVAQNIETLLICRALDGIWFSAPMTLVGGTLADLWR 245
Cdd:cd17325 35 LIVAAYALAQLLFSPpagrLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAP 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 246 TEERGVPMAAFSAAPFIGPAIGPLIGGFLSDAAGWRWLYYIQIIFAFIVWILITFTVPETYAPTILARRakkmreqtgeq 325
Cdd:cd17325 115 PEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAV----------- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 326 ehvteqdlDLRPFAERLRIFLIRPFqllfgeliVFLISLYMSVLYGLLYMFFVAFPIVYQEGKGYSAGTTGLMFiplALG 405
Cdd:cd17325 184 --------SAARLRSGLRLLLRDRR--------LLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLF---GAQ 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 406 VIASALCAPIVNRNYMTQVRKynghppaevrliPMMCSCWFIpIGLFIFAWTSYPHLHWIGPAIGGFPVGFGFIFlyNAA 485
Cdd:cd17325 245 GLASALSQPPAGKLSDRIGRK------------PLILIGLLL-SAVALLLLPLATSFWLLLLLLALLGLGLGLVF--PAT 309
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 486 NNYLVDSYQHQA-ASALAaktFLRSFWGAAVV---LFTEQMYARLGYQWAsSLLGFIALACCAIPFVFWV 551
Cdd:cd17325 310 LALLADIVPPEGrGTAMG---LFNTAFSLGMVlgpLLGGFLYDAFGFATP-FLAAAALLLLAAVLFLLLR 375
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
131-545 |
4.28e-25 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 107.27 E-value: 4.28e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 131 VVASTCFVVALASSIITADLIGVEEEFNVSE-EVALVsITVFVMGFGIgpMMF--APLSEVVGRRWIYGVTLFLAVIFII 207
Cdd:cd17474 3 AVFFATLLAVLGVSIVDPILPAIAEALGASPaQVGLL-ITAFTLPAAV--LMPvaGVLADRFGRKKVLLPGLLLFGIGGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 208 PCAVAQNIETLLICRALDGIWFSAPMTLVGGTLADLWRTEERGVPMAAFSAAPFIGPAIGPLIGGFLSdAAGWRWLYYIQ 287
Cdd:cd17474 80 LCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 288 IIFAFIVWILITFTVPETYAPTilarrakkmreqtgeqEHVTEQDLDLRPFAERLRIFLirpfqllfgeLIVFLISLYMS 367
Cdd:cd17474 159 AALIPVAFLAILFLLPEPKEKA----------------KSSSATKLRDLKKALRGRGLL----------TFLVSAFLYFF 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 368 VLYGLLymffVAFPIVYQEGKGYSAGTTGLMFIPLALGVIASAL-CAPIVNRNYMTQvrkynghppaevRLIPMMCSCWF 446
Cdd:cd17474 213 LYFAFL----TYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLfVGRLLKKRFGAR------------RILVIGLLLYA 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 447 IPIGLFIFAwtsyPHLHWIGPAIGGFPVGFGFIF-LYNAANNYLVDSyqHQAASALAAKTFLRSFWGAAVVLFTEQMYAR 525
Cdd:cd17474 277 LSLLLLGFV----PSLALLLIAIVLFGLGLGLNLpLLTTLVTELAPE--EERGTASSLYNFVRFLGQAVGPLLFGLLLEI 350
|
410 420
....*....|....*....|
gi 154295116 526 LGYQWASSLLGFIALACCAI 545
Cdd:cd17474 351 FGLSAPFLVGAAIALAAAVL 370
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
136-549 |
3.59e-24 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 104.82 E-value: 3.59e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 136 CFVVALASSIITADLIGVEEEFNVSEEVALVSITVFVMGFGIGPMMFAPLSEVVGRRWIYGVTLFLAVIFIIPCAVAQNI 215
Cdd:cd06174 5 FFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 216 ETLLICRALDGIWFSAPMTLVGGTLADLWRTEERGVPMAAFSAAPFIGPAIGPLIGGFLSDA--AGWRWLYYIQIIFAFI 293
Cdd:cd06174 85 WLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAALALL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 294 VWILITFTVPETyaptilarrakkmreqtgeqehvteQDLDLRPFAERLRIFLIRPFQLLFGELIVFLISLYMSVLYGLL 373
Cdd:cd06174 165 AAILLLLVVPDP-------------------------PESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAY 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 374 YMFFVAFPIVYQEGKGYSAGTTGLMFIPLALGVIASALCAPIVNRNYMTqvrkynghppaevRLIPMMCSCWFIPIGLFI 453
Cdd:cd06174 220 YSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIG-------------RKPLLLIGLLLMALGLAL 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 454 FAWTSYPHLHWIGPAIGGFPVGFGFIFLYNAANNYLVDSYQHQAASALAAKTFLRSFWGAAVVLFTEQMyarlGYQWASS 533
Cdd:cd06174 287 LLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAA----TFGLTGA 362
|
410
....*....|....*.
gi 154295116 534 LLGFIALACCAIPFVF 549
Cdd:cd06174 363 FLVLAVLLLLAAILLL 378
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
122-555 |
2.08e-22 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 99.17 E-value: 2.08e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 122 KAFKWYITMVVASTCFVVALASSIITADLIGVEEEFNVSEEVALVSITVFVMGFGIGPMMFAPLSEVVGRRWIYGVTLFL 201
Cdd:COG2271 5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 202 AVIFIIPCAVAQNIETLLICRALDGIwFSAPMTLVGGTL-ADLWRTEERGVPMAAFSAAPFIGPAIGPLIGGFLSDAAGW 280
Cdd:COG2271 85 WGLATLLFGFATSFWQLLLLRFLLGL-GEAGFFPAALKLiAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 281 RWLYYIQIIFAfIVWILITFtvpetyaptilarrakkmreqtgeqehvteqdldlrpfaerlriflirpfqllfgelivF 360
Cdd:COG2271 164 RAAFLILGLPG-LLLALLRF-----------------------------------------------------------W 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 361 LISLYMSVLYGLLYMFFVAFPIVYQEGKGYSAGTTGLMF-IPLALGVIASALCAPIVNRnymtqvrkynghpPAEVRLIP 439
Cdd:COG2271 184 LLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLsLPFLAGIVGSLLGGWLSDR-------------LGRRRKLV 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 440 MMCSCWFIPIGLFIFAWTsyPHLHWIgpAIGGFPVGFGFIFLYNAANNYLVDSY-QHQAASALAAKTFLRSFWGAAVVLF 518
Cdd:COG2271 251 LAIGLLLAALALLLLALL--PSPALA--IALLFLAGFGLGGAFGLLWALAAELFpKKARGTASGLVNTFGFLGGALGPLL 326
|
410 420 430
....*....|....*....|....*....|....*..
gi 154295116 519 TEQMYARLGYQWASSLLGFIALACCAIPFVFWVWGAK 555
Cdd:COG2271 327 VGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
157-515 |
1.48e-20 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 93.99 E-value: 1.48e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 157 FNVSEEVALVSITVFVMGFGIGPMMFAPLSEVVGRRWIYGVTLFLAVIFIIPCAVAQNIETLLICRALDGIWFSAPMTLV 236
Cdd:TIGR00710 35 LSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAGSVIS 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 237 GGTLADLWRTEERGVPMAAFSAAPFIGPAIGPLIGGFLSDAAGWRWLYYIQIIFAFIVWILITFTVPETyaptilarRAK 316
Cdd:TIGR00710 115 QALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILPET--------LPY 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 317 KMREQTGEQehvteqdldlrpfaerlriflIRPFQLLFGELIVFLISLYMSVLYGLLYMFFVAFPIVYQEGKGYSAGTTG 396
Cdd:TIGR00710 187 EARIQISTY---------------------FETFLLLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSVFG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 397 LMFIPLALGVIASAlcapIVNRNYMTQVRKYNghppaevrLIPMMCSCWFIPIGLFIFAWTSyPHLHWIGPAIGGFPVGF 476
Cdd:TIGR00710 246 LLFALNIIAMIFGG----FLNGRFIKKWGAKS--------LLRMGLILFAVSAVLLEITAIL-GLGSWAMIIGPMMFVGI 312
|
330 340 350
....*....|....*....|....*....|....*....
gi 154295116 477 GFIFLYNAANNYLVDSYQHQAASALAAKTFLRSFWGAAV 515
Cdd:TIGR00710 313 GNSMISSIAMAYALEDFPHVAGTASALFGTLRLVLGAIV 351
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
129-544 |
1.06e-18 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 87.99 E-value: 1.06e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 129 TMVVASTCFVVALASSIITADLIGVEEEFNVSEEVALVSITVFVMGFGIGPMMFAPLSEVVGRRWIYGVTLFLAVIFIIP 208
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 209 CAVAQNIETLLICRALDGIWFSAPMTLVGGTLADLWRTEERGVPMAAFSAAPFIGPAIGPLIGGFLSDAAGWRWLYYIQI 288
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 289 IFAFIVWILITFTVPetyaptilarrakkmreqtgeqehvteqdlDLRPFAeRLRIFLIRPFQLLFGELIVFLISLYMSV 368
Cdd:cd17324 161 VLALLAALLLWRLLP------------------------------SLPPKK-PGSLGLLSSLLLLLRNPRLRLAYLITFL 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 369 LYGLLYMFFVAFPIVYQE-GKGYSAGTTGLMFIPLALGVIASALCAPIVNRNYMTQVrkynghppaevrlipMMCSCWFI 447
Cdd:cd17324 210 LFGGFFALYTYLAPFLTDvPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRAL---------------LIALLLLA 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 448 PIGLFIFAWTSyphlHWIGPAIGGFPVGFGFIFLYNAANNYLVDSyqHQAASALAAKTFLRSFW--GAAVVLFTEQMYAR 525
Cdd:cd17324 275 AALLLLTLLGP----SPLLLLVGLVLWGLGFFAAHSALQTRVLRL--APEARGLASSLYLAAYNlgGALGAALGGLVLDH 348
|
410 420
....*....|....*....|..
gi 154295116 526 LGYQ---WASSLLGFIALACCA 544
Cdd:cd17324 349 GGWAgvgWVGAALLLLALLLAL 370
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
155-308 |
1.04e-17 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 85.35 E-value: 1.04e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 155 EEFNVSEEVALVSITVFVMGFGIGPMMFAPLSEVVGRRWI--YGVTLFLAVIFIipCAVAQNIETLLICRALDGIWFSAP 232
Cdd:PRK11102 19 ADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVilGGTLVFALAAVA--CALAQTIDQLIYMRFLHGLAAAAA 96
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 154295116 233 MTLVGGTLADLWRTEERGVPMAAFSAAPFIGPAIGPLIGGFLSDAAGWRWLYYIQIIFAFIVWILITFTVPETYAP 308
Cdd:PRK11102 97 SVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPETLPK 172
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
132-545 |
2.64e-17 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 83.78 E-value: 2.64e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 132 VASTCFVVALASSIITADLIGVEEEFNVSE-EVALVSITVFVMGFGIGPMMfAPLSEVVGRRWIYGVTLFLAVIFIIPCA 210
Cdd:cd17504 1 LALAALAVMLVETMLSPALPTIQREFGTSAaAVSWVLTAYLLVGAVSTPIL-GRLGDLYGRKKVLLIVLAIYTAGSLLAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 211 VAQNIETLLICRALDGIWFSA-PMTLvgGTLADLWRTEERGVPMAAFSAAPFIGPAIGPLIGGFLSDAAGWRWLYYIQII 289
Cdd:cd17504 80 FAPNLPVLIAGRALQGIGGAVfPLAF--ALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 290 FAFIVWILITFtvpetyaptilarrakkmreqtgeqehvteqdLDLRPFAERlriflirpfQLLFGELIVFLISLYMsvl 369
Cdd:cd17504 158 VAVLLAALVPL--------------------------------IDLRLLRRR---------NVLLANITALLAGFGM--- 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 370 ygllYMFFVAFPIVYQEGKGYSAG----TTGLMFIPLALGVIASalcAPIVNRnymtQVRKYNGHPPAEVRLIPMMcscw 445
Cdd:cd17504 194 ----FMVFQLLPQLLQLPTPTGFGlgitEAGLLLLPGALVMLIA---GPLAGR----LIARVGPRRVLLIGLVISA---- 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 446 fipIGLFIFAwtsYPHLHWIGPAIGGFPVGFGFIFLYNAANNYLVDSY-QHQAASALAAKTFLRSF---WGAAVVLFTEQ 521
Cdd:cd17504 259 ---VGLLLLA---LLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVpPDRTGIATGMNTVLRTIgsaIGPAIAGAILT 332
|
410 420
....*....|....*....|....*....
gi 154295116 522 MYARLGYQWASS-----LLGFIALACCAI 545
Cdd:cd17504 333 TYTVSITSGGVPtegayVLAFLIGAALAL 361
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
137-300 |
2.75e-16 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 81.90 E-value: 2.75e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 137 FVVALASSIITAdligVEEEFNVSEEVALVSITVFVMGfGIGPMMFAPLSEVVGRRWIYGVTLFLAVIFIIPCAVAQNIE 216
Cdd:cd06179 12 FGVTLPAAVLPF----IVADLGPSSNSTWISTAWSLAQ-AVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVN 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 217 TLLICRALDGIWFSApMTLVGGTLADLWRTEERGVPMAAFSAAPFIGPAIGPLIGGFL--SDAAGWRWLYYIQIIFAFIV 294
Cdd:cd06179 87 MLIGGQALIGIGAGT-QGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALveANAAGWRWIFYINAIFNALA 165
|
....*.
gi 154295116 295 WILITF 300
Cdd:cd06179 166 LILLFF 171
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
125-563 |
4.12e-15 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 77.61 E-value: 4.12e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 125 KWYITMVVASTCFVVALAS----SIITADLigvEEEFNVSEEVALVSITVFVMGFGIGPMMFAPLSEVVGRRWIYGVTLF 200
Cdd:COG2223 2 GRWRVLLLATLAFFLAFGVwylwSVLAPPL---AEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 201 LAVIFIIPCAVAQNIETLLICRALDGIW----FSAPMTLVggtlADLWRTEERGVPMAAFSAAPFIGPAIGPLIGGFLSD 276
Cdd:COG2223 79 LLGIGLLLLALAVSYWLLLLLGLLLGIGgggsFAVGIALV----SKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 277 AAGWRWLYYIQIIFAFIVWILITFTVPETYAPTILARRAkkmreqtgeqehvteqdldlrPFAERLRIFLIRPFQLLFge 356
Cdd:COG2223 155 AFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKA---------------------SLRDQLEALRDPRFWLLS-- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 357 livflisLYMSVLYGLLYMFFVAFPIVYQEGKGYSAGTTG-LMFIPLALGVIASALCAPIVNRnymtqvrkyngHPPAEV 435
Cdd:COG2223 212 -------LLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGlLAALFALLGALGRPLGGWLSDR-----------IGGRRV 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 436 rlipMMCSCWFIPIGLFIFAWTSYPhlhwIGPAIGGFPVGFGFIFLYNAANNYLVDSY--QHQAASALAaktFLRSFWGA 513
Cdd:COG2223 274 ----LLIVFALMALGLLLLALALGS----LWLFLVLFLLLGLALGGGNGAVFALVPDIfpTKNAGAVYG---LVGAAGGL 342
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 154295116 514 AVVLFteQMYARLGYQWASSL-LGFIALACCAIPFVFWVWGAKIREKSRFA 563
Cdd:COG2223 343 GGFLG--PLLFGALLDATGSYtAAFLVFAVLALVALVLTLLLYRRPRRAAA 391
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
131-480 |
2.67e-14 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 74.92 E-value: 2.67e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 131 VVASTCFVVALASSIITADLIGVEEEFnVSEEVALVSITVFVMGFGIgpMMFAP----LSEVVGRRWIYGVTLFLAVIFI 206
Cdd:cd17473 3 TLLLASTLTVMAGAAIAPALPAIAQHF-VPNSELLVPLLLTLPALFI--ALFAPlagwLADRFGRKRLLIAGLLLYGIGG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 207 IPCAVAQNIETLLICRALDGIWFSAPMTLVGGTLADLWRTEERGVPMAAFSAAPFIGPAIGPLIGGFLSDaAGWRW--LY 284
Cdd:cd17473 80 VAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRApfLV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 285 YiqiIFAFIVWILITFTVPETyaptilaRRAKKMREQTGeqehvteqdldlrpfAERLRIFLIRPFQLLFGelIVFLISL 364
Cdd:cd17473 159 Y---LLALPVLILVLLFLPEP-------ARKSKSAASPG---------------AATAAALPWKRVLPIYF--LAFLAML 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 365 ymsvlygLLYMFFVAFPIVYQEGKGYSAGTTGLMFIPLALGVIASALCAPIVNRNYMTQvrkynghppaevRLIPMMCSC 444
Cdd:cd17473 212 -------LFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKR------------RLLAIGFAL 272
|
330 340 350
....*....|....*....|....*....|....*.
gi 154295116 445 WFipIGLFIFAWTsyPHLHWIGPAIGGFPVGFGFIF 480
Cdd:cd17473 273 MA--LGFLLLALA--SGLWVVLLGAILAGLGFGLLL 304
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
156-493 |
4.32e-14 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 74.26 E-value: 4.32e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 156 EFNVSEEVALVSITVFVMGFGIGPMMFAPLSEVVGRRWIYGVTLFLAVIFIIPCAVAQNIETLLICRALDGIWFSApMTL 235
Cdd:cd17371 28 EFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGG-EWA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 236 VGGTL-ADLWRTEER----GVPMAAFSAAPFIGPAIGPLIGGFLSDAAGWRWLYYIQIIFAFIVWiLITFTVPETyapti 310
Cdd:cd17371 107 AGAALmAEYVPARHRgkalGYVQSGWAVGWLLATLLAALLFPLLPPEIAWRVLFLLGALPALLVL-FIRRFVKEP----- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 311 lARRAKKMREQTGEQEHVTEQDLDLRPFaerLRIFLirpfqllfgelivfLISLYMSVLYGLLYMFFVAFPIVYQEGKGY 390
Cdd:cd17371 181 -PQWQAARAARRHFADRPSLRELFSPPL---LRTTL--------------LASLLATGALGGYYGITTWLPSYLTGERGL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 391 SAGTTG--LMFIPLA--LGVIASALCAPIVNRNYMTqvrkynghppaevrLIPMMCSCWFIPiglfifaWTSYPHLHWIG 466
Cdd:cd17371 243 SFEGSAgyLVVTILGgfLGYLAGGFLADRIGRRNNF--------------ALFALGSAISIL-------LYFFLPLSPTL 301
|
330 340
....*....|....*....|....*..
gi 154295116 467 PAIGGFPVGFGFIFLYNAANNYLVDSY 493
Cdd:cd17371 302 ILILGFPLGFFASGPFSGMGAYLTELF 328
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
137-541 |
7.98e-14 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 73.00 E-value: 7.98e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 137 FVVALASSIITADLIGVEEEFNVSEEVALVsITVFVMGFGIGPMMFAP----LSEVVGRRWIYGVTLFLAVIFIIPCAVA 212
Cdd:cd17330 6 FLDALGFGIVFPVLPFYVREFNKLGASGYY-VGLLQSSYSLGQFLASPlwgrLSDRYGRKPVLLLSLAGSAVSYVLLGLS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 213 QNIETLLICRALDGIwFSAPMTLVGGTLADLWRTEERGVPMAAFSAAPFIGPAIGPLIGGFLSDAAGWRWLYYIQIIFAF 292
Cdd:cd17330 85 RNLWLLFLARFLDGL-TGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALAL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 293 IVWILItftvpetyaptilarrakkmreqtgeqehvteqdldlrpfaerlrIFLIRPFQLLFgeLIVFLISLYMSVLYGL 372
Cdd:cd17330 164 LNLVLV---------------------------------------------LFFLPPLRRLL--LVYFLIALAFAGLESV 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 373 LYMFFVAFPivyqegkGYSAGTTGLMFIPLAL-GVIASALCAPIVNRNYmtqvrkynghppAEVRLIPMMCSCWFipIGL 451
Cdd:cd17330 197 FSLFLKDRF-------GFSPSQIGLLLALVGIaGILAQLLLIPRLAKRL------------GERKLLRLGLLLAI--IGL 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 452 FIFAWTSYPHLHWIGPAIGGFPVGFGFIFLYNAANNYLVDSYQHQAASALAAktfLRSFWGAAVVLFTEQMYARLGYQWA 531
Cdd:cd17330 256 LLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQS---LQSLARIIGPLLAGPLYSFLGPGVP 332
|
410
....*....|
gi 154295116 532 SSLLGFIALA 541
Cdd:cd17330 333 FLLAAGLLLI 342
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
137-482 |
1.11e-12 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 69.97 E-value: 1.11e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 137 FVVALASSIITADLIGVEEEFNVSEEVALVSITVFVMGFGIGPMMFAPLSEVVGRRwiyGVTLFLAVIFIIPC---AVAQ 213
Cdd:PRK15402 23 FATYIANDMIQPGMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRR---PVMLAGVAFFILTClaiLLAQ 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 214 NIETLLICRALDGIwfsaPMTLVG--GTLADLWRTEER-GVPMAAFSA-APFIGPAIGPLIGGFLSDAAGWRWLYYIQII 289
Cdd:PRK15402 100 SIEQFTLLRFLQGI----GLCFIGavGYAAIQESFEEAdAIKITALMAnVALLAPLLGPLVGAALIHVLPWRGMFVLFAA 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 290 FAFIVWILITFTVPETyaptilarrakkmreqtgeqEHVTEQDLDLRPfaerlrifLIRPFQLLFGELIVFLISLYMSvL 369
Cdd:PRK15402 176 LAALSFFGLWRAMPET--------------------AGRVGEKLSLKE--------LGRDYKLVLKNRRFVAGALALG-L 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 370 YGLLYMFFVAF-PIVYQEGKGYSAGTTGLMFIPLALGVIASALC-APIVNRnymTQVRkynghppaevRLIPMmcSCWFI 447
Cdd:PRK15402 227 VSLPLLAWIALsPVILISGEQLSSYEYGLLQVPVFGALIAGNLTlARLTSR---RPLR----------SLIRM--GLWPM 291
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 154295116 448 PIGLFIFA----WTSYPHLhWI--GPAIGGFPVGFGFIFLY 482
Cdd:PRK15402 292 VAGLLLAAlatvISSHAYL-WLtaGLSLYAFGIGLANAGLY 331
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
145-304 |
2.24e-12 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 69.19 E-value: 2.24e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 145 IITADLIGVEEEFNVSEEVALVSITVFVMGFGIGPMMFAPLSEVVGRRWIYGVTLFLAVIFIIPCAVAQNIETLLICRAL 224
Cdd:cd17328 17 TIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 225 DGIWFSAPMTLVGGTLADLWRTEERGVPMAAFSAAPFIGPAIGPLIGGFLSDAA-GWRWLYYIQIIFAFIVWILITFTVP 303
Cdd:cd17328 97 VGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVLGVLLAILLLLFVR 176
|
.
gi 154295116 304 E 304
Cdd:cd17328 177 E 177
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
128-551 |
3.23e-12 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 68.36 E-value: 3.23e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 128 ITMVVASTCFVVALASSIITADLIgvEEEFNVSEEVALVSITVFVMGFGIgpmmFAPLSEVVGRRWIYGVTLFLAVIFII 207
Cdd:COG2807 21 LAIVLVALNLRPAITSVGPLLPEI--RADLGLSATQAGLLTTLPLLAFGL----FAPLAPRLARRFGLERTLLLALLLLA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 208 PC----AVAQNIETLLICRALDGIWFSApMTLVGGTLADLWRTEERGVPMAAFSAAPFIGPAIGPLIGGFLSDAAGWRWL 283
Cdd:COG2807 95 AGlllrSLAPSVALLLAGTALIGAGIAV-GNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGA 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 284 YYIQIIFAFI---VWILitftvpetyaptiLARRAKKMREQTgeqehvteqdldlrPFAERLRIFLIRPfqllfgelIVF 360
Cdd:COG2807 174 LAVWALLALLallLWLP-------------LLRRRPAAAAAA--------------PAAASLRSLWRSP--------LAW 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 361 LISLYMSVLYGLLYMFFVAFPIVYQEgKGYSAGTTGLMFIPLALGVIASALCAPIVnrnymtqVRKYNGHPPaevrLIPM 440
Cdd:COG2807 219 LLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLLLSLFQLAGIPGSLLVPLL-------ADRLGDRRP----LLLL 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 441 MCSCWFIPIGLFIFAWTSYPhlhWIGPAIGGFPVGFGFIFLYNAANNYLVDsyqHQAASALAAKTFLRSFWGAAVV-LFT 519
Cdd:COG2807 287 LGLLGLAGLLGLLLAPGSLP---WLWAVLLGLGQGGLFPLALTLIGLRART---PAEAAALSGMAQSVGYLLAALGpLLV 360
|
410 420 430
....*....|....*....|....*....|..
gi 154295116 520 EQMYARLGyQWASSLLGFIALACCAIPFVFWV 551
Cdd:COG2807 361 GALHDATG-SWTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
132-551 |
4.10e-12 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 68.12 E-value: 4.10e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 132 VASTCFVVALASSIITADLIGVEEEFNVSEEVALVSITVFVMGFGIGPMMFAPLSEVVGRRWIYGVTLFLAVIFIIPCAV 211
Cdd:cd17333 1 LYISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 212 AQNIETLLICRALDGIWFSAPMTLVGGTLADLWRtEERGVPMAAFSAAPFIGPAIGPLIGG-FLSDAAGWRWLYYIQIIF 290
Cdd:cd17333 81 TPSIYLFVVLMFLAGLGAGILDTGANTFVGALFE-ESSATRLNVLHGFFGLGALIGPLIATsLLTSELSWSWAYLIIGLI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 291 AFIVWILITFTvpetyaptilarrakKMREQTGEQEHVTEQDLDLRPFAERLRIFLIRpfqllfgeLIVFLISLYMsvly 370
Cdd:cd17333 160 YLLLAILILLT---------------LFPELPSARNPQQSVGAFSASASRLLRNPSII--------LGALALFLYV---- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 371 GLLYMFFVAFPIVYQEGKGYSAGTTGLMFIPLALGVIASALC-APIVNRNymtqvrkynghppAEVRLIPMMCSCWFipI 449
Cdd:cd17333 213 GAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLgGPISRRI-------------KPHTLLVLSGSGAL--L 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 450 GLFIFAWTSYPHlhwiGPAIGGFPVGFGFIFLYNAANNYLVDSYQHQAASALAAKTFLRSFwGAAVVLFteqMYARLGYQ 529
Cdd:cd17333 278 GLLILLLAPTLV----VGLVATALLGLFMAALFPTILSLGISNLPYAKGKGTSVLLAAGSI-GGAIIPF---IMGFIAEA 349
|
410 420
....*....|....*....|..
gi 154295116 530 WASSLLGFIALACCAIPFVFWV 551
Cdd:cd17333 350 VGIQTAMLLITILYAIIFVLAL 371
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
153-307 |
4.76e-12 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 67.60 E-value: 4.76e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 153 VEEEFNVSEEVALVSITVFVMGFGIGPMMFAPLSEVVGRRWIYGVTLFLAVIFIIPCAVAQNIETLLICRALDGIwFSAP 232
Cdd:cd17319 29 IMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGV-AEAG 107
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 154295116 233 MTLVGGTLADLW-RTEERGVPMAAFSAAPFIGPAIGPLIGGFLSDAAGWRWLYYIQIIFAFIVWILITFTVPETYA 307
Cdd:cd17319 108 FFPGAIKALAEWfPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQVWG 183
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
137-545 |
7.95e-12 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 66.86 E-value: 7.95e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 137 FVVALASSIITADLIGVeeeFNVSEEVALVSITVFVMGfgIGPMMFAPLSEVVGRRWIYGVTLFLAVIFIIPCAVAQNIE 216
Cdd:cd17316 16 FLIGFVAPVLAAEFSLG---LSLLQTGLLFAAGFLGRP--IGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 217 TLLICRALDGIWFSAPMTLVGGTLADLWRTEERGVPMAAFSAAPFIGPAIGPLIGGFLSDAA----GWRWLYYIQIIFAF 292
Cdd:cd17316 91 LLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLsgdwGWRILFLIGALPAL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 293 IVWILitftvpetyaptilarrakkmreqtgeqehvteqdldlrpfaeRLRIFLirpfqllfgeLIVFLISLYMSVlygl 372
Cdd:cd17316 171 LALLL-------------------------------------------RRRTLL----------LILLWFFISFGY---- 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 373 lYMFFVAFPIVYQEGKGYSAGTTGLMFIPLAL----GVIASALCAPIVNRNYMtqvrkynghppaevrlipMMCSCWFIP 448
Cdd:cd17316 194 -YGLTTFLPTYLQTVLGLSPATSSLYLLLISLgalvGALIAGLLSDRIGRKKT------------------LVIGLILSG 254
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 449 IGLFIFAWTSYPHLHWIgpAIGGFPVGFGFIFLYNAANNYLVDSY-QHQAASALAAKTFLRSFWGAAVVLFTEQMYARLG 527
Cdd:cd17316 255 ILALPLFYLLSGSPTLL--LLLLFILSFFVGGVWGALYAYLAELFpTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTG 332
|
410
....*....|....*...
gi 154295116 528 YQWASSLLGFIALACCAI 545
Cdd:cd17316 333 GTGVPALILALLAIVALI 350
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
137-416 |
2.64e-11 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 65.62 E-value: 2.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 137 FVVALASSIITADLIGVEEEFNVSEEVALVSITVFVMGFGIGPMMFAPLSEVVGRRwiyGVTLFLAVIFIIPCA---VAQ 213
Cdd:PRK15403 26 FAAYLTTDLIQPGIINVVRDFNADVSLAPASVSLYLAGGMALQWLLGPLSDRIGRR---PVLITGALIFTLACAatlFTT 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 214 NIETLLICRALDG--IWFSAPMTLVggTLADLWRTEERGVPMAAFSAAPFIGPAIGPLIGGFLSDAAGWRWLYYIQIIFA 291
Cdd:PRK15403 103 SMTQFLIARFIQGtsICFIATVGYV--TVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHFVHWKVLFAIIAVMG 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 292 FIVWILITFTVPETyaptilarrakkmreqtgeqehVTEQDLDLRPFAerlrifLIRPFQLLFGELIVFLISLYMSVLYg 371
Cdd:PRK15403 181 LIAFVGLLLAMPET----------------------VKRGAVPFSAKS------VLRDFRNVFRNRLFLTGAATLSLSY- 231
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 154295116 372 LLYMFFVAF-PIVYQEGKGYSAGTTGLMFIPLALGVI-ASALCAPIV 416
Cdd:PRK15403 232 IPMMSWVAVsPVILIDAGGMTTSQFAWTQVPVFGAVIvANAIVARFV 278
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
170-424 |
7.15e-11 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 64.16 E-value: 7.15e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 170 VFVMGFGIgpmmfapLSEVVGRRWIYGVTLFLAVIFIIPCAVAQNIETLLICRALDGI--WFSAPMTLvggtLADLWRTE 247
Cdd:cd17472 47 IFQIPFGL-------LSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSgaISSVVMAL----LADLTREE 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 248 ERGVPMAAFSAAPFIGPAIGPLIGGFLSDAAGWRWLYYIQIIFAFIVWILITFTVPEtyaptilarrakkmreqtgEQEH 327
Cdd:cd17472 116 NRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPD-------------------PPKI 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 328 VTEQDldlrPFAERLRIFLIRPFQLLFGeLIVFLISLYMSvlygllyMFFVAFPIvYQEGKGYSAGTTGLMFIPLALGVI 407
Cdd:cd17472 177 VQISE----KEKKKLKKLLKNKRLLRLD-FSIFILHFVLM-------AFFYILPL-LLTQLGGGKGQLWKVYLPAILIGF 243
|
250
....*....|....*....
gi 154295116 408 ASALCAPIV--NRNYMTQV 424
Cdd:cd17472 244 ILMVPFVIYaeKKGKMKQV 262
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
130-305 |
1.12e-10 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 63.44 E-value: 1.12e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 130 MVVASTCFVVALASSIITADLIGVEEEFNVSEEVALVSITVFVMGFGIGPMMFAPLSEVVGRRWIYGVTLFLAVIFIIPC 209
Cdd:cd17476 1 ATISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 210 AVAQNIETLLICRALDGIwfsAPMTLVGGTLADLWRT----EERGVPMAAFSAAPFIGPAIGPLIGGFLSDAAGWRWLYY 285
Cdd:cd17476 81 GFSPNFIFFIICRALQGL---GPAFLLPNAMALLGRTyppgPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFW 157
|
170 180
....*....|....*....|.
gi 154295116 286 IQIIFAFIVWIL-ITFTVPET 305
Cdd:cd17476 158 FLAILAAIVAVAaIFWTSPSF 178
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
165-321 |
4.78e-10 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 61.60 E-value: 4.78e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 165 LVSITVFvmGFGIGPMMFAPLSEVVGRRWIYGVTLFLAVIFIIPCAVAQNIETLLICRALDGIWFSAPMTLVGGTLADLW 244
Cdd:TIGR00895 57 LFSAGLI--GMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYA 134
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 154295116 245 RTEERGVPMAAFSAAPFIGPAIGPLIGGFLSDAAGWRWLYYIQIIFAFIVWILITFTVPETYAPTILaRRAKKMREQ 321
Cdd:TIGR00895 135 PKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESIDFLVS-KRPETVRRI 210
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
169-503 |
6.67e-10 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 61.07 E-value: 6.67e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 169 TVFVMGFGIGPMMFA---------PLSEVVGRRWIYgvtLFLAVIFIIPCAV---AQNIETLLICRALDGIWFSAPMTLV 236
Cdd:cd17489 29 SEAVAGLVVGLFTLAallarpfagRLLDRFGRKRLL---LIGLLIFALATLLyllATSVALLLVLRLIHGIGWGAFTTAA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 237 GGTLADLWRTEERGVPMAAFSAAPFIGPAIGPLIGGFLSDAAGWRWLYYIQIIFAFIVWILItFTVPETYAPTILARRAK 316
Cdd:cd17489 106 ATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLV-FLVKDPPPVAAEEAEAG 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 317 KmreqtgeqehvteqdldlrpfaeRLRIFLIRPFQLLFGeLIVFLISLYMSVLygllyMFFVAfpiVYQEGKGYSAGTTG 396
Cdd:cd17489 185 T-----------------------RAFRRLVEKKVLPPA-LILFLASIAYGAI-----STFLP---LYAAERGISNAGLF 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 397 LMFIPLALgVIASALCAPIVNRnymtqvrkyngHPPAEVrLIPMMCscwFIPIGLFIFAWTSYPHLHwigpAIGGFPVGF 476
Cdd:cd17489 233 FTVYAIAL-LLSRPFSGKLSDR-----------KGPKTV-IIPGLL---LLALGLLLLSFAGSPWML----LLAAVLYGL 292
|
330 340
....*....|....*....|....*...
gi 154295116 477 GFIFLYNAANNYLVD-SYQHQAASALAA 503
Cdd:cd17489 293 GFGLLFPALQALAVDlVPPHRRGAANGT 320
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
171-481 |
1.09e-09 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 60.47 E-value: 1.09e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 171 FVMGFGIGPMMFAPLSEVVGRRWIYGVTLFLAVIFIIPCAVAQNIETLLICRALDGIWFSAPMTLVGGTLADLWRTEERG 250
Cdd:TIGR00881 39 FSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 251 VPMAAFSAAPFIGPAIGPLIGGF-LSDAAGWRWLYY----IQIIFAFIVWILITFTvPETYAptilARRAKKMREQtgEQ 325
Cdd:TIGR00881 119 TWVSFWNCSHNVGGGLLPPLVLFgIAELYSWHWVFIvpgiIAIIVSLICFLLLRDS-PQSCG----LPPAEEMPNE--EP 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 326 EHVTEQDLDLRpfaERLRIFLirpfQLLFGELIVFLISLYMSVLYGLLYMFFVAFPIVYQEGKGYSAGTTGLMFIPLALG 405
Cdd:TIGR00881 192 DGDAEKKEEEL---TKKQIFL----QYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELG 264
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 154295116 406 VIASALCAPIV-NRNYmtqvrKYNGHPPAEVRLIPMMCSCwfipIGLFIFAWTSYPHLHWIGPAIGGFpvGFGFIFL 481
Cdd:TIGR00881 265 GLVGTLLAGWLsDKLF-----NGRRGPLAVFFMALIIVSL----LVYWLNPAANPLMDLICLFALGFL--VYGPQML 330
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
120-300 |
6.25e-09 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 58.04 E-value: 6.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 120 WSKAFKWYITMVVASTCFVVALASSIITADL-IGVEEEFNVSEEVALVSITVF-VMGFGigPMMFAP----LSEVVGRRW 193
Cdd:cd17391 194 WNSVPNPSLLISLFVTTFIIQLANQSIEPILtLYIRQLMGDASNLAFISGLVFsATGVS--SLLSAPrlgkLGDRIGHHR 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 194 IYGVTLFLAVIFIIPCAVAQNIETLLICRALDGIWFSAPMTLVGGTLADLWRTEERGVPMAAFSAAPFIGPAIGPLIGGF 273
Cdd:cd17391 272 ILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSA 351
|
170 180
....*....|....*....|....*....
gi 154295116 274 LSDAAGWRWLYYIQIIFAFI--VWILITF 300
Cdd:cd17391 352 IAAHFGYRAVFVVTALLVLLnaIWSFIFL 380
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
106-301 |
8.87e-09 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 57.58 E-value: 8.87e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 106 LVTFLPDDPENPKNWSKAF-----------KWYITMVVASTCFVVALASSIITADLIgVEEEFNVSEEVALVSITVFVMG 174
Cdd:cd17474 168 AILFLLPEPKEKAKSSSATklrdlkkalrgRGLLTFLVSAFLYFFLYFAFLTYLPFL-LELLYGISPIIIGLLFAGWSVL 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 175 FGIGPMMFAPLSEV-VGRRWIY--GVTLFLAVIFIIPcaVAQNIETLLICRALDGIWFSAPMTLVGGTLADLWRTEERGV 251
Cdd:cd17474 247 LALGSLFVGRLLKKrFGARRILviGLLLYALSLLLLG--FVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGT 324
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 154295116 252 PMAAFSAAPFIGPAIGPLIGGFLSDAAGWRWLYYIQIIFAFIVWILITFT 301
Cdd:cd17474 325 ASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
158-296 |
1.12e-08 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 57.23 E-value: 1.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 158 NVSEEVALVSITVFVMGFGIGPMMFAPLSEVVGRRWIYGVTLFLAVIFIIPCAVA--QNIETLLICRALDGIWFSAPMTL 235
Cdd:cd17316 209 GLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLlsGSPTLLLLLLFILSFFVGGVWGA 288
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 154295116 236 VGGTLADLWRTEERGVPMAAFSAAPFIGPAIGPLIGGFLSDAAG----WRWLYYIQIIFAFIVWI 296
Cdd:cd17316 289 LYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGgtgvPALILALLAIVALIVAL 353
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
156-305 |
2.24e-08 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 56.45 E-value: 2.24e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 156 EFNVSEEVALVSITVFVMGFGIGPMMFAPLSEVVGRR--WIYGVTLFLAVIFIIpcAVAQNIETLLICRALDGIWfsapm 233
Cdd:PRK11652 37 DLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRpvILVGMSIFILGTLVA--LFAHSLTVLIAASAIQGLG----- 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 234 TLVGGTLAdlwRTEER----GVPMAAF----SAAPFIGPAIGPLIGGFLSDAAGWRWLYYIQIIFAFIVWILITFTVPET 305
Cdd:PRK11652 110 TGVGGVMA---RTLPRdlyeGTQLRHAnsllNMGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLGAGVTFSMARWMPET 186
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
166-325 |
2.53e-08 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 56.12 E-value: 2.53e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 166 VSITVFVMGFgigpmmFAP----LSEVVGRRWIYGVTLFLAVIFIIPCAVAQNIETLLICRALDGI---WFSAPMTLVGG 238
Cdd:cd17391 42 FSSTFLVSAI------FSPiwgrLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVfsgYVPNATALIAS 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 239 TLAdlwrTEERGVPMAAFSAAPFIGPAIGPLIGGFLSDAAGWRWLYYIQIIFAFIVWILITFTVPETYAPtilarRAKKM 318
Cdd:cd17391 116 QTP----KEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLFFVKEDFKP-----VEKKK 186
|
....*..
gi 154295116 319 REQTGEQ 325
Cdd:cd17391 187 MVSTKEV 193
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
163-408 |
5.23e-08 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 55.31 E-value: 5.23e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 163 VALVSITVFVMGFGIGPmmfapLSEVVGRRWIYGVTLFLAVIFIIPCAVAQNIETLLICRALDGIWFSAPMTLVGGTLAD 242
Cdd:cd17329 41 LALSAVAGIVASLIGGR-----LADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIAD 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 243 LWRTEERGVPMAAFSAAPFIGPAIGPLIGGFLSDaAGWRWLYYIQIIFAFIVWILITFTVPETYAPTilaRRAKKMreqt 322
Cdd:cd17329 116 VTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAAAVLFLLAALVLLFLLPETRPKR---RAAEKT---- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 323 geqehvteqdldlrPFAERLRIFLI-RPFQLLFGelivflislyMSVLYGLLYM-FFVAFPIVYQEGKGYSAGTTGLMFI 400
Cdd:cd17329 188 --------------EILRGYKIVLRdRAFLLFLL----------ASFLISLIYFqLESTLPVYVVEILGLGESLLGLLLA 243
|
....*...
gi 154295116 401 PLALGVIA 408
Cdd:cd17329 244 LNALLIVL 251
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
129-321 |
7.30e-08 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 55.44 E-value: 7.30e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 129 TMVVASTCFVVALASSIitadLIGVEEEFNVSEEVALVSiTVFVMGFGIGPMMFAPLSEVVGRRWIYGVTLFLAVIFIIP 208
Cdd:pfam06609 50 SLNVCATYFVLQASASA----LPNILQDIGQSENQGLFS-TLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGLVGAIV 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 209 CAVAQNIETLLICRALDGIwFSAPMTLVGGTLADLWRTEERGVPMAAFSAAPFIGPAIGPLIGGFLSDAAGWRWLYYIQI 288
Cdd:pfam06609 125 GCTANKFNTLLAAMTLLGV-AAGPAGASPLFIGELMSNKTKFLGLLIVSAPTIAMNGAGPYFGQRLAIQGNWRWIFYIYI 203
|
170 180 190
....*....|....*....|....*....|...
gi 154295116 289 IFAFIVWILItftVPETYAPTILARRAKKMREQ 321
Cdd:pfam06609 204 IMSAIAVLLI---IIWYHPPSFAQLHGKKARKR 233
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
123-297 |
8.92e-08 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 54.47 E-value: 8.92e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 123 AFKWYITMVVASTCFV---VALASSIITAdligVEEEFNVSEEVALVSITVFVMGFGIGPMMFAPLSEVVGRRWIYGVTL 199
Cdd:COG0738 208 KNPRLLLGGLAIFLYVgaeGAIGDWLPLY----LKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSA 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 200 FLAVIFIIPCAVAQNIETLLICRALDGIwFSAPM--TLVGGTLADLwrTEERGVPMAAFSAAPFIGPAIGPLIGGFLSDA 277
Cdd:COG0738 284 LLAAVGLLLALLAPGPWLALIGLALVGL-GLSLMfpTIFSLALDGL--GKRTAAAVSAVLIMGIVGGAIGPPLIGFLADA 360
|
170 180
....*....|....*....|
gi 154295116 278 AGWRWLYYIQIIFAFIVWIL 297
Cdd:COG0738 361 FGLRAAFLVPLVCYLLILLL 380
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
164-545 |
2.68e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 53.00 E-value: 2.68e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 164 ALVSITVFVmgFGIGPMMFAPLSEVVG-----RRWIYGVTLFLAVIFIIPCAVA----QNIETLLICRALDGIWFSAPMT 234
Cdd:cd06173 34 LLVGLVLAA--FFLPFLLFSPFAGVLAdrfdrRRLLILADLLRALLAAVLALLAllgsLSLWLLLVLAFLLGIASAFFGP 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 235 LVGGTLADLWRTEERGVPMAAFSAAPFIGPAIGPLIGGFLSDAAGWRWLYYIQIIFAFIVWILITFTVPETYAPTILARR 314
Cdd:cd06173 112 ARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSS 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 315 AKKMReqtgeqehvteqdldlrpfAERLRIFLIRPFQLLFGELIVFLISLYMSvlygllyMFFVAFPIVYQEGKGYSAGT 394
Cdd:cd06173 192 LLLRD-------------------LREGLRYLRRSPLLRLLLLALALFALLGG-------ALTVLLPLLAKEVLGGGAAG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 395 TGLMFIPLALG-VIASALCAPIVNRNymtqvrkynghppAEVRLipMMCSCWFIPIGLFIFAWTSYPHLHWIGPAIGGFP 473
Cdd:cd06173 246 YGLLLAAFGVGaLLGALLLGRLSKRR-------------RRGRL--LLIGALLLGLALLVLGLSPSLWLLLAALFLLGLA 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 154295116 474 VGFGFIFLYNAANNYLVDSYQHQAASALAAktflrSFWGAAVV--LFTEQMYARLGYQWASSLLGFIALACCAI 545
Cdd:cd06173 311 GGLFNVPLNTLLQLRVPDELRGRVFSVYNA-----LNSGAMPLgaLLAGLLADALGLSAVFLLAGALLLLAALL 379
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
116-560 |
2.70e-07 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 52.93 E-value: 2.70e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 116 NPKNWSKAFkWYITMVVASTCFVVALASSIITAdligVEEEFNVSEEVALVSITVFVMGFGIGPMMFAPLSEVVGRRWIY 195
Cdd:COG0738 2 SKKNYRRAL-IAIYLLFFLWGFATALWGPLIPA----LKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 196 GVTLFLAVIFIIPCAVAQNIETLLICRALDGIWFSAPMTLVGGTLADLWRtEERGVPMAAFSAAPFIGPAIGPLIGGFL- 274
Cdd:COG0738 77 LLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGP-ETAASRLNLLHAFFSLGALLGPLLGGLLi 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 275 --SDAAGWRWLYYIQIIFAFIVWILITFTvpetyaptilarrakKMREQTGEQEHVTEQDLDLRpfaerlriFLIRPFQL 352
Cdd:COG0738 156 llGLSLSWHLPYLILAVLLLLLALLFLRS---------------KLPEIEEEEEEAAGSAASLK--------SLLKNPRL 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 353 LFGELIVFlisLYMsvlyGLLYMFFVAFPIVYQEGKGYSAGTTGLMFIPLALGVIASALCAPIVNRNYmtqvrkynghpp 432
Cdd:COG0738 213 LLGGLAIF---LYV----GAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRF------------ 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 433 AEVRLipMMCSCWFIPIGLFIFAWTSYPHLHWIGPAIGGFPVGFGFIFLYNAANNYLVDSYQHQAASALAAktflrSFWG 512
Cdd:COG0738 274 GPVRL--LRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIM-----GIVG 346
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 154295116 513 AAVV-LFTEQMYARLGYQWAssllGFIALACCAIPFVFWVWGAKIREKS 560
Cdd:COG0738 347 GAIGpPLIGFLADAFGLRAA----FLVPLVCYLLILLLALALKRKRRKK 391
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
128-307 |
2.72e-07 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 53.01 E-value: 2.72e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 128 ITMV--VASTCFVVALASSIITADLIGVEEEFNVSEEVALVSITVFVMGFGIGPMMFAPLSEVVGRRWIYGVTLFLAVI- 204
Cdd:cd17318 20 VAIVamVNSTATHDNNNTSTDKDTLPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALl 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 205 -FIIPCAVAQNIETLLICRALDGIWFSAPMTLVGGTLADLWRTEERGV-PMAAFSAAPFiGPAIGPLIGGFLSDAAGWRW 282
Cdd:cd17318 100 tLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRlTSIAYSGSQF-GTVIAMPLSGFLCESLGWPS 178
|
170 180
....*....|....*....|....*
gi 154295116 283 LYYIQIIFAFIVWILITFTVPETYA 307
Cdd:cd17318 179 IFYIFGGLGLLWCLLWFFLVLPVWA 203
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
136-318 |
3.02e-07 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 52.95 E-value: 3.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 136 CFVVALA-------SSIITADLIGVEEEFNVSEEVALVSITVFVMGFGIGPMMFAPLSEVVGRRwiyGVTLFLAVIFIIP 208
Cdd:cd17359 3 SLVAALGgllfgydTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRR---KTLLISAVLFFIS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 209 ---CAVAQNIETLLICRALDGIWFSAPMTLVGGTLADLWRTEERG--VPMAAFS------AAPFIGPAIGPLIGGFLSDA 277
Cdd:cd17359 80 algSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGrlVSLNQLMivfgqlLAYIVNYLIANAGGADWLGA 159
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 154295116 278 AGWRWLYYIQIIFAFIVWILItFTVPETyaPTILARRAKKM 318
Cdd:cd17359 160 EGWRWMLGLEAIPAILFLLGM-LFIPES--PRWLVSKGKPI 197
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
155-286 |
5.49e-07 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 51.82 E-value: 5.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 155 EEFNVSEEVA--LVSITVFvmGFGIGPMMFAPLSEVVGRRWIYGVTLFLAVIFIIPCAVAQNIETLLICRALDGIWFSAP 232
Cdd:cd17365 27 QDWGLSPAQLgpVGSAALF--GMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAA 104
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 154295116 233 MTLVGGTLADLWRTEERGVPMAAFSAAPFIGPAIGPLIGGFLSDAAGWRWLYYI 286
Cdd:cd17365 105 MPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLL 158
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
111-308 |
5.96e-07 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 52.23 E-value: 5.96e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 111 PDDPENPKNWSKAFkwyitMVVASTCFVVALASSIITADLIGVEEEFNVSEEVAL--VSITVFVMGF---GIGPMMFAPL 185
Cdd:PRK09874 3 PCENDTPINWKRNL-----TVAWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSALnmWSGLVFSITFlfsAIASPFWGGL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 186 SEVVGRRWIYGVTLFLAVIFIIPCAVAQNIETLLICRALDGiwfsapmtLVGGTLAD---LWRTE----ERGVPMAAFSA 258
Cdd:PRK09874 78 ADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLG--------LLGGFVPNanaLIATQvprnKSGWALGTLST 149
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 154295116 259 APFIGPAIGPLIGGFLSDAAGWRWLYYIQIIFAFIVWILITFTVPETYAP 308
Cdd:PRK09874 150 GGVSGALLGPLAGGLLADSYGLRPVFFITASVLFLCFLVTLFCIRENFQP 199
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
166-302 |
9.90e-07 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 51.04 E-value: 9.90e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 166 VSITVFVMGFGIGPMMFAPLSEVVGRRWIYGVTLFLAVIFIIPCAVAQNIETLLICRALDGIwFSAPMTLVGGTLA-DLW 244
Cdd:cd17317 29 LVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGV-TSAGIFTVGFVLGmEIV 107
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 154295116 245 RTEERGVPMAAFSAAPFIGPAIGPLIGGFLSDaagWRWLYYI----QIIFAFIVWILITFTV 302
Cdd:cd17317 108 GPKYRSFVGILFGLFWALGYMLLALLAYLIRD---WRWLQLAislpGLLFLLLLWWLPRRTI 166
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
111-263 |
1.43e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 50.74 E-value: 1.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 111 PDDPENPKNWSKAFKWYITMVVASTCFVVALASSIITADLIG-VEEEFNVSEEVALVSITVFVMGFGIGPMMFAPLSEVV 189
Cdd:COG2814 191 AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLyLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF 270
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 154295116 190 GRRWIYGVTLFLAVIFIIPCAVAQNIETLLICRALDGIWFSAPMTLVGGTLADLWRTEERGVPMAAFSAAPFIG 263
Cdd:COG2814 271 GRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
162-302 |
1.51e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 50.67 E-value: 1.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 162 EVALVSITVFVMGFGIGPMMFAP----LSEVVGRRWIYGVTLFLAVIFIIPCAVAQNIETLLICRALDGIWFSApMTLVG 237
Cdd:cd17489 223 ERGISNAGLFFTVYAIALLLSRPfsgkLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGL-LFPAL 301
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 154295116 238 GTLA-DLWRTEERGVPMAAFSAAPFIGPAIGPLIGGFLSDAAGWRWLYYIQIIFAFIVWILITFTV 302
Cdd:cd17489 302 QALAvDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
190-554 |
2.65e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 50.29 E-value: 2.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 190 GRR--WIYGVTLFLAVIFIIPCAVAQNIET-----LLICRALDGIWFSAPMTLVGGTLADLWRT-EERGVPMAAFSAAPF 261
Cdd:COG2211 78 GRRrpWILIGAIPLALSFVLLFTAPDLSPTgkliyALVTYLLLGLAYTLVNIPYSALGAELTPDyEERTRLSSWRFAFAG 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 262 IGPAIGPLIGGFL------SDAAGWRWLYYIQIIFAFIVWILITFTVPETYAPtilarrakkmreqtgEQEHVteqdldl 335
Cdd:COG2211 158 LGGLLASVLPPPLvaafggDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVP---------------EEEKV------- 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 336 rPFAERLRIFL-IRPFQLLfgeLIVFLISLYMSVLYGLLYMFFVAFPIvyqegkGYSAGTTGLMFIPLALGVIASALCAP 414
Cdd:COG2211 216 -SLKESLKALLkNRPFLLL---LLAYLLFFLALALVAALLLYYFKYVL------GLSAALVGLLLALYFLAALLGAPLWP 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 415 IVnrnymtqVRKYNghppaevRLIPMMCSCWFIPIGLFIFAWTSYPHLHW--IGPAIGGFPVGFGFIFLYN----AANNY 488
Cdd:COG2211 286 RL-------AKRFG-------KKKAFIIGLLLAALGLLLLFFLGPGNLWLllVLAALAGIGLGAILVLPWAmladVVDYD 351
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 154295116 489 LVDSYQHQAASALAAKTFLRSFWGAAVVLFTEQMYARLGY-----QWASSLLGfIALACCAIPFVFWVWGA 554
Cdd:COG2211 352 EWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYvagaaQSPSALTG-IRLLFFLLPAVLLLLAA 421
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
166-551 |
2.77e-06 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 49.94 E-value: 2.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 166 VSITVFVMGFGIGPMMFAPLSEVVGRRWIYGVTLFLAVIFIIPCAVAQNIETLLICRALDGIWFSAPMTLVGGTLADLWR 245
Cdd:cd17327 45 WGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYK 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 246 TEERGVPMAAFSAAPFIGPAIGPLIG-GFLS-----DAAGWRWLYYIQ--IIFAFIVWILITFTVPETYAP-------TI 310
Cdd:cd17327 125 REEQAKRIAFFYAAAGLGSIFGGLLAyGVFKilgvgGLAGWRWLFIIEglITIIIGLVIFFWLPDNPSKAWflteeekEL 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 311 LARRAKKMREQTGEQEhvteqdldlrpfaerlriFLIRPFQLLFGELIVFLISLYMSVLYGLLYMFFVAFPIVYQEGKGY 390
Cdd:cd17327 205 AVERLRANQTGKGDQK------------------FKWKQIKEAFKDPRTWLLFLFFFCSQITNNGISNFLPLILKSLGFY 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 391 SAGTTGLMFIPLALGVIASALCAPIVNRnymtqvrkynghppAEVRLIPMMCSCWFIPIGLFIF-AWTSYPHLHWIGpAI 469
Cdd:cd17327 267 SLQTNLLSVPIGALGAVSLLIAALLSDR--------------FKKRGLFAIFACVLALVGSIILlAAPNPPGAYFAA-YI 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 470 GGFPVGFGFIFLYNAANNYLVDSYqhqaasalaaktflrsfwGAAVVLFTEQMYARLGYQWASSLL----------GFIA 539
Cdd:cd17327 332 LGGGSYAGFPILLSWISSNCAGYT------------------KRATVLAIMLIFYNVGNIVAPQIFragdapryipGNIA 393
|
410
....*....|..
gi 154295116 540 LACCAIPFVFWV 551
Cdd:cd17327 394 LLVCACVSIVLS 405
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
164-305 |
3.02e-06 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 49.95 E-value: 3.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 164 ALVSItvFVMGFGIGPMMFAPLSEVVGRRW---IYGVTLFLAVIFIIPCAVAQNIETLLICRALDGIWFSAPMTLVGGTL 240
Cdd:cd17357 53 LIVSI--FFIGGAIGSFISAFLANRFGRKNgllISNALLVVSSLLMFLSKSAKSPELLIFGRFLVGIACGLSTGFVPMYL 130
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 154295116 241 ADLWRTEERGvpmaAFSAAPFIGPAIGPLIGGF------LSDAAGWRWLYYIQIIFAfIVWILITFTVPET 305
Cdd:cd17357 131 QEISPSELRG----ALGSLTQIGVTLGILLGQVfglpsvLGTETLWPYLLFFPGIPA-LLQLAALPFFPES 196
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
122-279 |
1.25e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 47.97 E-value: 1.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 122 KAFKWYITMVVASTCFVVALASSII--TADLIGVEEEFnvseeVALVSITVFVMGFgIGPMMFAPLSEVVGRRWIYGVTL 199
Cdd:COG2211 228 RPFLLLLLAYLLFFLALALVAALLLyyFKYVLGLSAAL-----VGLLLALYFLAAL-LGAPLWPRLAKRFGKKKAFIIGL 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 200 FLAVIFIIPCAVAQ--NIETLLICRALDGIWFSAPMTLVGGTLADL-----WRTEER--GVPMAAFSAAPFIGPAIGPLI 270
Cdd:COG2211 302 LLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLADVvdydeWKTGRRreGLYFGIFTFAIKLGQALAGAL 381
|
....*....
gi 154295116 271 GGFLSDAAG 279
Cdd:COG2211 382 AGLLLALFG 390
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
185-298 |
1.75e-05 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 47.22 E-value: 1.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 185 LSEVVGRRWIYGVTLFL-AVIFIIpCAVAQNIETLLICRALDGIwFSAPMTLVGGTLADLWRTEERGVPMAAFSAAPFIG 263
Cdd:cd17390 54 WSDVVGRRPVLLICLLLtALGYVL-LGFSTSLALLFLSRIPLGI-FKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLG 131
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 154295116 264 PAIGPLIGGFLS-DAAGWRWLYYIQ----IIFAFIVWILI 298
Cdd:cd17390 132 FILGPVVGGHLAeTDGGFYYVALLCsaifILNAGLVWFLL 171
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
185-303 |
2.06e-05 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 47.42 E-value: 2.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 185 LSEVVGRRWIYGVTLFLAVIFIIPCAVAQNIETLLICRALDGIWfSAPMTLVGG-TLADLWRTEERGVPMAAFSAAPFIG 263
Cdd:PRK10504 68 LADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARVLQGVG-GAMMVPVGRlTVMKIVPREQYMAAMTFVTLPGQVG 146
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 154295116 264 PAIGPLIGGFLSDAAGWRWLYYIQ----IIFAFIVWILI-TFTVP 303
Cdd:PRK10504 147 PLLGPALGGLLVEYASWHWIFLINipvgIIGAIATLMLMpNYTMQ 191
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
113-279 |
5.00e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 46.03 E-value: 5.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 113 DPENPKNWSKAFKWY-ITMVVASTCFVVALASSIITADLIGVEEEFNVSEEVALVSITVFVMGFGIGPMMFAPLSEVVGR 191
Cdd:cd17473 183 AASPGAATAAALPWKrVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGK 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 192 RWIYGVTLFLAVIFIIPCAVAQNIETLLICRALDGIWFSAPMTLVGGTLADLWRTEERGVPMAAFSAAPFIGPAIGPLIG 271
Cdd:cd17473 263 RRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVL 342
|
....*...
gi 154295116 272 GFLSDAAG 279
Cdd:cd17473 343 GPLVNLTG 350
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
135-268 |
6.29e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 45.49 E-value: 6.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 135 TCFVVALASSIITADLIGVEEEFNVSEEVALVSITVFVMGFGIGPMMFAPLSEVVGRRWIYGVTLFLAVIFIIPCAVAQN 214
Cdd:pfam07690 208 ALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSL 287
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 154295116 215 IET---LLICRALDGIWFSAPMTLVGGTLADLWRTEERGVPMAAFSAAPFIGPAIGP 268
Cdd:pfam07690 288 TLSslwLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
138-310 |
6.82e-05 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 45.26 E-value: 6.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 138 VVALASSIITADLigvEEEFNVSEEVALVSITVFvmGFGIGPMMFAPLSEVVGRRWIYGVTLFLAVIFIIPCAVAQNIET 217
Cdd:cd17315 15 VINGALLYIAKDL---GFGLSTSLQGLVVSSLLL--GAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 218 LLICRALDGIWFSAPMTLVGGTLADLWRTEERGVPMAAFSAAPFIGPAIGPLIGGFLS--DAAGWRWLYYIQIIFAFIVW 295
Cdd:cd17315 90 LIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSlsPPGWWRLMFALAAVPALLQL 169
|
170
....*....|....*
gi 154295116 296 ILITFTvPETYAPTI 310
Cdd:cd17315 170 LLMFFL-PESRALLV 183
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
129-316 |
1.06e-04 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 44.87 E-value: 1.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 129 TMVVASTCFVVALASSIITADLIGVEEEFNVSEEVALVSITVF--VMGFG--IGPMMFAPLSEVVGRRWIYGVTLFLAVI 204
Cdd:cd17358 4 TFVANLGSFSFGIAVGWSSPALPSLMSDNSLSLPLTVAQFSWFgsLLTLGalIGALLSGKLADRIGRKRTLLISAIPCIL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 205 FIIPCAVAQNIETLLICRALDGIWFSAPMTLVGGTLADLWRTEERGVPMAAFSAAPFIGPAIGPLIGGFLSdaagWRWLY 284
Cdd:cd17358 84 GWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFLP----WRTLA 159
|
170 180 190
....*....|....*....|....*....|..
gi 154295116 285 YIQIIFAFIVWILITFtVPETyaPTILARRAK 316
Cdd:cd17358 160 LIGAIPPVVFLILLFF-IPES--PRWLAKKGR 188
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
168-418 |
1.96e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 44.08 E-value: 1.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 168 ITVFVMGFGIGPMMFAPL----SEVVGRRWIYGVTLFLAVIFIIPCAVAQNIETLLICRALDGIWFSA--PmtlVGGTLA 241
Cdd:cd17478 33 AGLLVSVFSITSSLLQPLfgylADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAfhP---EGARLA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 242 DLWRTEERGVPMAAFSAAPFIGPAIGPLIGGFLsdAAGWRWL-YYIQIIFAFIVWILITFTVPETYAPTILARRAKKmre 320
Cdd:cd17478 110 SQAAGGRRGLAMSIFSVGGNLGFALGPLIAAAL--VALFGGLgLLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKS--- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 321 qtgeqehvteqdldlrPFAERLRIFLiRPFQLLFGelIVFLISLYMSVLygllymffVAFPIVYQEGKGYSAGTTGLM-F 399
Cdd:cd17478 185 ----------------SARSTLKGVW-RALLLLLI--IVFLRSWVLSSL--------TTFLPFYLVQRGYSLVFAGLLlS 237
|
250
....*....|....*....
gi 154295116 400 IPLALGVIASALCAPIVNR 418
Cdd:cd17478 238 LFLFAGAIGTLIGGPLSDR 256
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
129-418 |
2.18e-04 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 43.78 E-value: 2.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 129 TMVVASTCFVVALASSIITADLIGVEEEFNVSEEVALVSITVFVMGFGIGPMMFAP----LSEVVGRRWIYGVTLFLAVI 204
Cdd:cd17388 1 LIFILVTVLLDAMGIGLIMPVLPTLLREFVGDSADAATHYGVLLALYALMQFIFAPilgaLSDRFGRRPVLLLSLAGAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 205 FIIPCAVAQNIETLLICRALDGIwFSAPMTLVGGTLADLWRTEERGVPMAAFSAAPFIGPAIGPLIGGFLSDaAGWRWLY 284
Cdd:cd17388 81 DYLLMAFAPTLWWLYLGRIIAGI-TGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGE-ISPRAPF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 285 YIQIIFAFIVWILITFTVPETYAPTilARRAKKMREqtgeqehvteqdldLRPFaerlrifliRPFQLLFGelivflisl 364
Cdd:cd17388 159 LVAAGLNGLNFLLGLFVLPESLPPE--RRRAFRWRR--------------ANPF---------GSLRWLTG--------- 204
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 154295116 365 yMSVLYGLLYMFFVAFPI---------VYQEGK-GYSAGTTG--LMFIPLALGVIASALCAPIVNR 418
Cdd:cd17388 205 -FPGLLGLLAVFFLIQLIgqvpattwvLFTEDRfDWSPTMVGlsLAVFGLLHALFQAFVTGPIAKR 269
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
161-550 |
2.84e-04 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 43.80 E-value: 2.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 161 EEVALVSITVFVMGFG--IGPMMFAPLSEVVGRRWIYGVTLFLAVIFIIPCAVA---QNIETLLICRALDGI---WFS-- 230
Cdd:pfam00083 43 ALSVLSGLIVSIFSVGcfIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAkgkWSVYQLIVGRVLVGIgvgGASvl 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 231 APMTLvggtlADLWRTEERGvpmaAFSAAPFIGPAIGPLIGGFL-------SDAAGWRWLYYIQIIFAFIVWILITFtVP 303
Cdd:pfam00083 123 APMYI-----SEIAPKKLRG----ALGSLYQLAITFGILLAYIFglglnktSNSDGWRIPLGLQLVPALLLIIGLLF-LP 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 304 ETyaPTILARRAKKMREQTGEQEHVTEQDLDLRPFAERLRIFLIRPFQLLFGELIVFLISLYMSVLYGLLYMFFVAFP-- 381
Cdd:pfam00083 193 ES--PRWLVEKGRLEEAREVLAKLRGVPDVDRELDEIKDSLEAGQEAEKASWKELFSTKTRRQRLLIGVMLQIFQQLTgi 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 382 ---------IVYQEGKGYSAGTTGLMFIPLALGVIASALCAPIVNRNYMTQvrkynghppaeVRLIPMMCSCWFIPIGLF 452
Cdd:pfam00083 271 naifyysttIFENLGLSDSFLVTIIVGVVNFVFTFIAIFLVDRFGRRPLLL-----------LGAAGMAICFVILGIVAL 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 453 IFAWTSYphlhWIGPAIGGFpvGFGFIFLYNAANN-----YLVDSY-QHQAASALAAKTFLRSFWGAAVVLFTEQMYARL 526
Cdd:pfam00083 340 LGVSKSD----WAGIVAIVF--IALFIAFFAMGWGpvpwvIVSELFpLSVRSKAMALATAANWLANFLIGFLFPIITDAI 413
|
410 420
....*....|....*....|....*.
gi 154295116 527 GYQWasslLGFIALACCA--IPFVFW 550
Cdd:pfam00083 414 GLGY----TFFIFAGLLVlfIIFVFF 435
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
131-545 |
3.22e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 43.41 E-value: 3.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 131 VVASTCFVVALASSIITADLIGV----EEEFNVSEEVALVSITVFVMGFGIGPMMFAPLSEVVGRRWIYGV-TLFLAVIF 205
Cdd:cd17355 3 VVLAVTFLILILSWGIRYYFGVFiipiIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLgLLLLAAGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 206 IIpCAVAQNIETLLICRALDGIWFSAPMTLVGGTLADLWRTEE-RGVPMAAFSAAPFIGPAIGPLIGGFLSDAAGWRWLY 284
Cdd:cd17355 83 VL-LALATSLWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERrRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 285 yiqIIFAFIVWILITftvpetyaPTILARRakkmREQTGEQEHVTEQDLDLRPFAERLRIFLIRPFQLLFGELIVFLISL 364
Cdd:cd17355 162 ---LVLALLALLVLV--------PVLLLLR----RRPADLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAV 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 365 YmsvlygllymFFVAFPIVYQEGKGYSAGTTGLMFIPLALGVIASALCAPIVNRNYmtqvrkynghpPAEVRLIPMMcsc 444
Cdd:cd17355 227 V----------GLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRY-----------SPRRLLAASY--- 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 445 wfipiGLFIFAWTSYPHLHWIGPAIGGFPVGFGFIFL-------YNAANNYLVDSY---------QHQAASALAAktflr 508
Cdd:cd17355 283 -----ALRALGLALLLLLPFPPLALLLFAALFGLGWGatvpltaALAARYFGARSYgtlfglvfaPHQLGSALGP----- 352
|
410 420 430
....*....|....*....|....*....|....*...
gi 154295116 509 sfWGAAVvlfteqMYARLG-YQWASSLLGFIALACCAI 545
Cdd:cd17355 353 --WLGGL------LYDRTGsYTAAWALAVALGLIAALL 382
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
136-298 |
3.48e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 43.32 E-value: 3.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 136 CFVVALASSIITADLIGVEEEFNVSEEVALVSITVFVmgfgIGPMMFAP----LSEVVGRRW-IYGVTLFLAVIFIIPCA 210
Cdd:cd17477 197 AFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFV----LGGLLLQWplgwLADRFDRRRvLLGCALLGALAALLLPL 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 211 VAQNIETLLICRALDGIwFSAPMTLVGGTLA-DLWRTEERGVPMAAFSAAPFIGPAIGPLIGGFLSDAAGWRWLYYIQII 289
Cdd:cd17477 273 VPGLPLALLVLLFLWGG-AAGPLYTLALALAgDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAA 351
|
....*....
gi 154295116 290 FAFIVWILI 298
Cdd:cd17477 352 VALLFLLFL 360
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
132-551 |
3.67e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 42.93 E-value: 3.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 132 VASTCFVVALASSIITAdLIGVE-EEFNVSEEVALVSITVFVMGFGIGPMMFAPLSEVVGRRWIYGVTLFLAVIFIIPCA 210
Cdd:cd17477 1 LLLSVALLGLGSGLLLP-LLSLRlEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 211 VAQNIETLLICRALDGIWFSAPMTLVGGTLADLWRTEERGVPMAAFSAAPFIGPAIGPLIGGFLsDAAGWRWlYYIQIIF 290
Cdd:cd17477 80 LTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALV-GTAGALP-FLIAAVL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 291 AFIVWILITFT---VPETYAPTILARRAkkmreqtgeqehvteqdldlrpfaerlrifLIRPFQLLFgeLIVFLISLYMS 367
Cdd:cd17477 158 LLLALVPLLLTrraAPEIEEAESISLRR------------------------------LLRIAPLAL--LGAFVAGFLEG 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 368 VLYGLLymffvafPiVYQEGKGYSAGTTGLMfipLALGVIASALCA-PI------VNRnymtqvrkynghppaevRLIPM 440
Cdd:cd17477 206 AFYSLL-------P-LYGLRLGLSVAQAALL---LAAFVLGGLLLQwPLgwladrFDR-----------------RRVLL 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 441 MCSCWFIPIGLFIFAWTSYPHLHWIGPAIGGfpvgfGFIF-LYNAANNYLVDSY-QHQAASALAAKTFlrsFWGAAVVLF 518
Cdd:cd17477 258 GCALLGALAALLLPLVPGLPLALLVLLFLWG-----GAAGpLYTLALALAGDRLpGDELVAANAALLL---LYGLGSVIG 329
|
410 420 430
....*....|....*....|....*....|...
gi 154295116 519 TeqMYARLGYQWASSLLGFIALACCAIPFVFWV 551
Cdd:cd17477 330 P--LLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
154-305 |
3.82e-04 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 42.96 E-value: 3.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 154 EEEFNVSEEVALVSITVFVMGFGIGPMMFAPLSEVVGRRW--IYGVTLF-LAVIFIipcAVAQNIETLLICRALDGIWFS 230
Cdd:PRK11043 33 QADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPvlLAGLSLFaLGSLGM---LWVESAAQLLVLRFVQAVGVC 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 231 APMTLVGGTLADLWRTEE-RGV-----PMAAFSaapfigPAIGPLIGGFLSDAAGWRWLYYIQIIFAFiVWILITFTVPE 304
Cdd:PRK11043 110 SAAVIWQALVIDRYPAQKaNRVfatimPLVALS------PALAPLLGAWLLNHFGWQAIFATLFAITL-LLILPTLRLKP 182
|
.
gi 154295116 305 T 305
Cdd:PRK11043 183 S 183
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
180-297 |
4.96e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 42.60 E-value: 4.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 180 MMFAPLSEVVGRRWIYGVTLFLAVIFIIPCAVAQNIETLLICRAL----DGIWFSAPMTLVggtlADLWRTEERGVPMAA 255
Cdd:cd17329 254 FPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVltlgEMLVFPAVQTLV----AALAPPDKRGSYMGF 329
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 154295116 256 FSAAPFIGPAIGPLIGGFLSDAAGWRWLYYIQIIFAFIVWIL 297
Cdd:cd17329 330 YALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAAL 371
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
111-300 |
5.55e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 42.60 E-value: 5.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 111 PDDPENPKNWSKAFKW------YITMVVASTCFVVALA-SSIITADLIGveeeFNVSEEVALVSI-TVFVmgfGIGPMMF 182
Cdd:cd17353 197 AENSPRDYTPREMLRTptfwllWLMFFLNATAGLMLIGqAKPIGQEFAG----LDAGIAALAVSIlSIFN---GGGRPFW 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 183 APLSEVVGRRWIY-GVTLFLAVIFIIPCAVAQNIETLLICRALDGIWFSAPMTLVGGTLADLWRTEERGVPMAAFSAAPF 261
Cdd:cd17353 270 GWLSDKIGRKNTLsIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKG 349
|
170 180 190
....*....|....*....|....*....|....*....
gi 154295116 262 IGPAIGPLIGGFLSDAAGWRWLYYIQIIFAFIVWILITF 300
Cdd:cd17353 350 VGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALALL 388
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
169-298 |
5.58e-04 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 42.65 E-value: 5.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 169 TVFVMGFGIGPMMFAPLSEVVGRRWIYGVTLFLAVIFIIPCAVAQNIETLLICRALDGIWFSAPMTLVGGTLADLWRTEE 248
Cdd:cd17312 45 SAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKE 124
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 154295116 249 RGVPMAAFSAAPFIGPAIGPLIGGFLSDAAGWRWLYYI----QIIFAFIVWILI 298
Cdd:cd17312 125 RGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVpgivGLVVAIILFFFL 178
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
185-321 |
8.40e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 41.82 E-value: 8.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 185 LSEVVGRRWIY-----GVTLFLAVIFIIpcavAQNIETLLICRALDGI----WFSAPMTLVGgtladLWRTEERGVPMAA 255
Cdd:cd17490 54 LSDRIGKRKLFiiiglLFTVLASLIMIL----FPSPWGLLIARFLSGIaaatWVSFTVLYAS-----YFPPDEAAKAMGL 124
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 154295116 256 FSAAPFIGPAIGPLIGGFLSDAAGWRWLYYIQIIFAFIVWILITFTVPETYAPTILARRAKKMREQ 321
Cdd:cd17490 125 INLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREKKPVLTELKELLSV 190
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
153-305 |
8.42e-04 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 41.90 E-value: 8.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 153 VEEEFNVSEEVALVSITVFVMGFGIGPMMFAPLSEVVGRRWIY-----GVTLFLAVIFIIPcavaQNIETLLICRALDGI 227
Cdd:cd17371 236 LTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFalfalGSAISILLYFFLP----LSPTLILILGFPLGF 311
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 154295116 228 WFSAPMTLVGGTLADLWRTEERGVPMAAFSAAPFIGPAIGPLIGGFLSDAAGWRWLYYIQIIFAFIVWILITFTVPET 305
Cdd:cd17371 312 FASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALLLPET 389
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
158-298 |
1.12e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 41.39 E-value: 1.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 158 NVSEEVALVSITVFVMGFGIGPMMFAPLSEVVGRRWIYGVTLFLAVIFIIPCAVAQNIETLLICrALDGIWFSAPMTLVG 237
Cdd:cd17478 226 GYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILL-VLAGFLLFASFPVTV 304
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 154295116 238 GTLADLWRteeRGVPMA-------AFSAApfigpAIGPLIGGFLSDAAGWRWLYYIQIIFAFIVWILI 298
Cdd:cd17478 305 VLAQELLP---GNVGLAsglmmglSFGLG-----GIGAPVLGALADAFGLESVLLILALLPLLGALLA 364
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
185-298 |
1.91e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 40.68 E-value: 1.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 185 LSEVVGRRWIYGVTLFLAVIFIIPCAVAQNIETLLICRALDGIWFSaPMTLVGGTLADLW-RTEERGVPMAAFSAAPFIG 263
Cdd:cd17475 54 LLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYG-SVQPGGGRAIMRWfPPRERGLAMGIRQTGVPLG 132
|
90 100 110
....*....|....*....|....*....|....*....
gi 154295116 264 PAIGPLIGGFLSDAAGWRWLYYIQ----IIFAFIVWILI 298
Cdd:cd17475 133 GALAAALLPPLALHYGWRAAFVVAglvsILAAVLFWLFY 171
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
126-298 |
2.04e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 40.68 E-value: 2.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 126 WYITMVVASTCFVVALASSIITADLIGVEEEFNVSEEVALVSITVFVMGFGIGPMMFAPLSEVVGRRWIYGVTLFLAVIF 205
Cdd:cd06173 208 PLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLA 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 206 IIPCAVAQNIETLLICRALDGIWFSAPMTLVGGTLADLWRTEERGVPMAAFSAAPFIGPAIGPLIGGFLSDAAGWRWLYY 285
Cdd:cd06173 288 LLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFL 367
|
170
....*....|....*.
gi 154295116 286 IQ---IIFAFIVWILI 298
Cdd:cd06173 368 LAgalLLLAALLLLLL 383
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
169-297 |
4.49e-03 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 39.48 E-value: 4.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 169 TVFV---MGFGIGPMMFAPLSEVVGRRWIYGVTLFLAVIFIIPCAVAQNIETLLICRALDGIWF----SAPMTLVGgTLA 241
Cdd:cd17384 234 TAFLpdsIGYLIGTNLFGPLAHKIGRWLCSLLGMLLVGISLILIPLAKNIYGLIIPHFGLGLGIgmvdSSMMPLLA-YLV 312
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 242 DLWRTEERGVPMAAFSAAPFIGPAIGPLIGGFLSDAAGWRWLYYI----QIIFAFIVWIL 297
Cdd:cd17384 313 DLRHSSVYGSVYAIADVAFCLAFALGPSLGGAIVKSIGFPWLMRIigiiNILYAPLLFFL 372
|
|
| MFS_SLC22A15 |
cd17377 |
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ... |
158-236 |
5.60e-03 |
|
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340935 [Multi-domain] Cd Length: 353 Bit Score: 39.38 E-value: 5.60e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 154295116 158 NVSEEVALVSiTVFVMGFGIGPMMFAPLSEVVGRRWIYGVTLFLAVIFIIPCAVAQNIETLLICRALDGIwFSAPMTLV 236
Cdd:cd17377 36 NAAYKVSLAS-SFFFAGVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGV-MNGGMSLV 112
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
185-307 |
6.09e-03 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 39.07 E-value: 6.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 185 LSEVVGRRW--IYG--VTLFLAVI------FIIPCAVAQNIETLLICRAL----DGIWFSAPMTLVGGTLadlwRTEERG 250
Cdd:cd17380 49 LTQVLGGYLadRFGgkKVLLLAVAlwslatLLTPLLAYSSLPLLILSRILlglgEGVHFPSMTSLFSRWV----PVSERS 124
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 154295116 251 VPMAAFSAAPFIGPAIGPLIGGFLSDAAGWRWLYYIqIIFAFIVWILITFT-VPETYA 307
Cdd:cd17380 125 RAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYF-FGLLGLLWALVWLIyLPPVWA 181
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
169-305 |
7.18e-03 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 38.93 E-value: 7.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 169 TVFVMGFGIGPMMFAPLSEVVGRRWIYGVTLFLAVIFIIPCAVAQNIETLLICRALDGI---WFSAPMTLVggtLADLWR 245
Cdd:cd17488 45 SLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILFGFSSSLWAFAVLWTLNAFfqgWGWPPCARL---LTHWYS 121
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 246 TEERGVPMAAFSAAPFIGPAIGPLIGGFLSDAAGWRWLYYIQIIFAFIVWILITFTVPET 305
Cdd:cd17488 122 RNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGMYVPGIIAILMGIVLCWRLRDR 181
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
134-319 |
7.68e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 39.07 E-value: 7.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 134 STCFVVALASSII--TADLIGVEEeFNVSE-EVALVSITVFVMGFGIGpMMFAPLSEV-VGRRWIYGVTLFLAVIFIIPC 209
Cdd:cd17471 3 LATLLTGLAGAFVlpYLSLFLTEE-LGASPlQIGIFMTLSALSGIVVS-QWLGRLSDRgGDRKPLILLALLAGALGYLLF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 210 AVAQNIETLLICRALdgiWFSAPMTLVGGTLA------DLWRTEERGVPMAAFSAAPFIGPAIGPLIGGFLSDAAGWRWL 283
Cdd:cd17471 81 AFLRNYWVLLLVGVV---LLSLGAAAFPQLFAlareyaDRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGL 157
|
170 180 190
....*....|....*....|....*....|....*.
gi 154295116 284 YYIQIIFAFIVWILITFTVPETYAPTILARRAKKMR 319
Cdd:cd17471 158 FLLAALLYLVVALLVLFLLPSVKPPAQKATPASSLV 193
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
256-300 |
8.23e-03 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 38.74 E-value: 8.23e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 154295116 256 FSAAPFIGPAIGPLIGGFLSDAAGWRWLYYIQIIFAFIVWILITF 300
Cdd:cd17385 344 FNAAFSLGAFIGPTLGGFLLERLGFEWAATIQAGLAFVVGILMSI 388
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
165-306 |
9.58e-03 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 38.77 E-value: 9.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154295116 165 LVSItvFVMGFGIGPMMFAPLSEVVGRRW-IYGVTLFLAVIFIIPCAVAQNIETLLICRALDGIWFSAPMTLVGGTLADL 243
Cdd:cd17356 50 IVSI--VNLGSFFGALISSFLSDRIGRKKsIQIGCVIYIIGAIIQVAAIGKWYQLIVGRIIAGLGVGFASVLVPVYQSEV 127
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 154295116 244 WRTEERGVPMAAFSAAPFIGPAIGPLIG---GFLSDAAGWRWLYYIQIIFAFIVWILITFtVPETY 306
Cdd:cd17356 128 APKHIRGTLVSLYQLAITIGILVAYCINygtHKLDGSAQWRIPLGLQIVWGLLLLIGMFF-LPESP 192
|
|
| |
