|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
13-382 |
5.92e-56 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 188.53 E-value: 5.92e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 13 ILVFQSFLLGTSEFIIVGVLPDIASDLNIAVTMVGNLVAIFAFVYAPLTPIGAAICSKFQRFRALIALLLVFLAGNVICT 92
Cdd:cd17324 3 ALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 93 FAVNYPMLLLARVVTASVSGVLVAVALTFGPDVTSRENQPRYMSWVFSGFSIASVFGMPMGTWIAGLAGWRTSFVVIDVL 172
Cdd:cd17324 83 LAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 173 TVVMIGVMFVVLPKRSVPSQVG---ILGQFKLFSDRRIILGVLTVVFGLASSYVWYTYLTPMFTNELHVPAAYVSVALVA 249
Cdd:cd17324 163 ALLAALLLWRLLPSLPPKKPGSlglLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 250 FGACCLWSNLYSGKLATRgtgiWPLVGMSKAYALQFVCMLLLPFATANAMLGSVLLVVLGLTIYLQNSPSQVLYSYVAET 329
Cdd:cd17324 243 FGVAGVVGSPLAGRLADR----GGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPE 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1539961710 330 GypgcGTLASSLNSTSCNLGIALGSAVGGVAYDAAGLRWLGPVGAVFAALAVL 382
Cdd:cd17324 319 A----RGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALL 367
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
2-352 |
2.71e-35 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 133.18 E-value: 2.71e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 2 ASHRLFTLPVAILVFQSFLLGTSEFIIVGVLPDIASDLNIAVTMVGNLVAIFAFVYAPLTPIGAAICSKFQRFRALIALL 81
Cdd:COG2814 3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 82 LVFLAGNVICTFAVNYPMLLLARVVTASVSGVLVAVALTFGPDVTSRENQPRYMSWVFSGFSIASVFGMPMGTWIAGLAG 161
Cdd:COG2814 83 LLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 162 WRTSFVVIDVLTVVMIGVMFVVLPKRSVPSQVGILGQFK-LFSDRRIILGVLTVVFGLASSYVWYTYLTPMFTNELHVPA 240
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLReLLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 241 AYVSVALVAFGACCLWSNLYSGKLATRGTGIWPLVGmskAYALQFVCMLLLPFATANAMLGsVLLVVLGLTIYLQNSPSQ 320
Cdd:COG2814 243 SAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLI---GLLLLALGLLLLALAGSLWLLL-LALFLLGFGFGLLFPLLQ 318
|
330 340 350
....*....|....*....|....*....|..
gi 1539961710 321 VLYSYVAETGYPGcgtLASSLNSTSCNLGIAL 352
Cdd:COG2814 319 ALVAELAPPEARG---RASGLYNSAFFLGGPL 347
|
|
| PRK03545 |
PRK03545 |
putative arabinose transporter; Provisional |
1-387 |
1.05e-29 |
|
putative arabinose transporter; Provisional
Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 118.45 E-value: 1.05e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 1 MASHRLFTLPVAILVFQSFLLGTSEFIIVGVLPDIASDLNIAVTMVGNLVAIFAFVYAPLTPIGAAICSKFQRFRALIAL 80
Cdd:PRK03545 1 TVSRKVAWLRVVTLALAAFIFNTTEFVPVGLLSDIAQSFHMQTAQVGLMLTIYAWVVALMSLPLMLLTSNVERRKLLIGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 81 LLVFLAGNVICTFAVNYPMLLLARVVTASVSGVLVAVALTFGPDVTSRENQPRYMSWVFSGFSIASVFGMPMGTWIAGLA 160
Cdd:PRK03545 81 FVLFIASHVLSALAWNFTVLLISRIGIAFAHAIFWSITASLAIRVAPAGKKAQALSLLATGTALAMVLGLPLGRVIGQYL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 161 GWRTSFVVIDVLTVVMIGVMFVVLPKrsVPSQVGilGQFK----LFSDRRIILGVLTVVFGLASSYVWYTYLTPMFTNEL 236
Cdd:PRK03545 161 GWRTTFLAIGGGALITLLLLIKLLPL--LPSEHS--GSLKslplLFRRPALVSLYLLTVVVVTAHFTAYSYIEPFVQQVA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 237 HVPAAYVSVALVAFGACCLWSNLYSGKLATRGtgiwPLVGMSKAYALQFVCMLLLPFATANAMLGSVLLVVLGLTIYLQN 316
Cdd:PRK03545 237 GLSENFATLLLLLFGGAGIIGSVLFSRLGNRH----PSGFLLIAIALLLVCLLLLLPAANSEWHLSVLSIFWGIAIMCIG 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1539961710 317 SPSQVLYSYVAetgyPGCGTLASSLNSTSCNLGIALGSAVGGVAYDAAGLRWLGPVGAVFAALAVLMTVLL 387
Cdd:PRK03545 313 LAMQVKVLKLA----PDATDVAMALFSGIFNIGIGAGALLGNQVSLHLGLSSIGYVGAALALAALVWSILI 379
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
14-368 |
3.33e-29 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 117.12 E-value: 3.33e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 14 LVFQSFLLGTSEFIIVGVLPDIASDLNIAVTMVGNLVAIFAFVYAPLTPIGAAICSKFQRFRALIALLLVFLAGNVICTF 93
Cdd:PRK10091 8 LALGTFGLGMAEFGIMGVLTELAHDVGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVIGNAMFTL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 94 AVNYPMLLLARVVTASVSGVLVAVALTFGPDVTSRENQPRYMSWVFSGFSIASVFGMPMGTWIAGLAGWRTSFVVIDVLT 173
Cdd:PRK10091 88 SSSYLMLAIGRLVSGFPHGAFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQEFSWRYTFLLIAVFN 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 174 VVMIGVMFVVLPKRSVPSQVGILGQFKLFSDRRIILGVLTVVFGLASSYVWYTYLTPMFTNELHVPAAYVSVALVAFGAC 253
Cdd:PRK10091 168 IAVLASIYFWVPDIRDEAKGGLREQFHFLRSPAPWLIFAATMFGNAGVFAWFSYIKPYMMFISGFSETSMTFIMMLVGLG 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 254 CLWSNLYSGKLATRGTgiwPLVGMSKAYALQFVCMLLLPFATANAMLGSVLLVVLGLTIYLQNSPSQVLYSYVAETGYpg 333
Cdd:PRK10091 248 MVLGNLLSGRLSGRYS---PLRIAAVTDFIIVLALLMLFFFGGMKTASLIFAFICCAGLFALSAPLQILLLQNAKGGE-- 322
|
330 340 350
....*....|....*....|....*....|....*
gi 1539961710 334 cgTLASSLNSTSCNLGIALGSAVGGVAYDaAGLRW 368
Cdd:PRK10091 323 --LLGAAGGQIAFNLGSAIGAYCGGMMLT-LGLAY 354
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
14-388 |
9.76e-28 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 112.67 E-value: 9.76e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 14 LVFQSFLLGTSEFIIVGVLPDIASDLNIAVTMVGNLVAIFAFVYAPLTPIGAAICSKFQRFRALIALLLVFLAGNVICTF 93
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 94 AVNYPMLLLARVVTASVSGVLVAVALTFGPDVTSRENQPRYMSWVFSGFSIASVFGMPMGTWIAGLAGWRTSFVVIDVLT 173
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 174 VVMIGVMFVVLP-------KRSVPSQVGILGQFKLFSDRRIILGVLTVVFGLASSYVWYTYLTPMFTNELHVPAAYVSVA 246
Cdd:cd17325 161 LLALVLALLLLPeprpppnKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 247 LVAFGACCLWSNLYSGKLATRGTGIWPLVGmskAYALQFVCMLLLPFATANAMLgSVLLVVLGLTIYLQNSPSQVLYSYV 326
Cdd:cd17325 241 FGAQGLASALSQPPAGKLSDRIGRKPLILI---GLLLSAVALLLLPLATSFWLL-LLLLALLGLGLGLVFPATLALLADI 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1539961710 327 AETGYPGcgtLASSLNSTSCNLGIALGSAVGGVAYDAAGLRWLGPVGAVFAALAVLMTVLLK 388
Cdd:cd17325 317 VPPEGRG---TAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
11-389 |
5.03e-24 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 102.27 E-value: 5.03e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 11 VAILVFQSFLLGTSEFIIVGVLPDIASDLNIAVTMVGNLVAIFAFVYAPLTPIGAAICSKFQRFRALIALLLVFLAGNVI 90
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 91 CTFAVNYPMLLLARVVTASVSGVLVAVALTFGPDVTSRENQPRYMSWVFSGFSIASVFGMPMGTWIAGLAGWRTSFVVID 170
Cdd:cd17320 81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 171 VLTVVMIGVMFVVLP-----KRSVPSQVGILGQFK-LFSDRRIILGVLTVVFGLASSYVWYTYLTPMFTNELHVPAAYVS 244
Cdd:cd17320 161 LLGLLLLLLVLLFLPetlpeEKRKPLLSSLLRAYKrVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 245 VALVAFGACCLWSNLYSGKLATRgTGIWPLVGMskAYALQFVCMLLLPFATANAMLGSVLLVVLGLTIYLQNSPSQVLYS 324
Cdd:cd17320 241 LLFALNAIALILGSLLNGRLVRR-FGPRRLLRL--GLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNAT 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1539961710 325 YVAETGYPGCGTLASSLNSTSCNLGIALGSAVGGVAYDaaglRWLGPVGAVFAALAVLMTVLLKV 389
Cdd:cd17320 318 SLALEPFPHVAGTASALLGFLQFLIGALAGALVGLLPN----GTALPMGLLILVLGLLALLLLIL 378
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
10-395 |
7.26e-21 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 93.41 E-value: 7.26e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 10 PVAILVFQSFLLGTSEFIIVGVL-PDIASDLNIAVTMVGNLVAIFAFVYAPLTPIGAAICSKFQRFRALIALLLVFLAGN 88
Cdd:COG2223 5 RVLLLATLAFFLAFGVWYLWSVLaPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 89 VICTFAVNYPMLLLARVVTASVSGVLVAVALTFGPDVTSRENQPRYMSWVFSGFSIASVFGMPMGTWIAGLAGWRTSFVV 168
Cdd:COG2223 85 LLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLI 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 169 IDVLTVVMIGVMFVVL----PKRSVPSQVGILGQFKLFSDRRIILGVLTVVFGLASSYVWYTYLTPMFTNELHVPAAYVS 244
Cdd:COG2223 165 LGILLLVVAVLAWLFLrdppAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 245 VALVAFGACCLWSNLYSGKLATRgtgIWPLVGMSKAYALQFVCMLLLPFATANAMLGSVLLVVLGLTIYLQNSpsqVLYS 324
Cdd:COG2223 245 LLAALFALLGALGRPLGGWLSDR---IGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNG---AVFA 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1539961710 325 YVAETGYPGCGTLASSLNSTSCNLGIALGSAVGGVAYDAAGLRWLG-PVGAVFAALAVLMTVLLKVNDGRRA 395
Cdd:COG2223 319 LVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAfLVFAVLALVALVLTLLLYRRPRRAA 390
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
14-354 |
1.62e-20 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 91.71 E-value: 1.62e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 14 LVFQSFLLGTSEFIIVGVLP-DIASDLNIAVTMVGNLVAIFAFVYAPLTPIGAAICSKFQRFRALIALLLVFLAGNVICT 92
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 93 FAVNYPMLLLARVVTASVSGVLVAVALTFGPDVTSRENQPRYMSWVFSGFSIASVFGMPMGTWIAGLAGWRTSFVVIDVL 172
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 173 TVVMIGVMFVVLPKRSVPSQVGILGQFKLFSD------RRIILGVLTVVFGLASSYVWYTYLTPMFTNELHVPAAYVSVA 246
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVawkallRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 247 LVAFGACCLWSNLYSGKLATRgTGIWPLVGMSKAYALQFVCMLLLPFATANAMLGSVLLVVLGLTIYLQNSPSQVLYSYV 326
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDR-LGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDL 319
|
330 340
....*....|....*....|....*...
gi 1539961710 327 AETGYPGcgtLASSLNSTSCNLGIALGS 354
Cdd:pfam07690 320 APKEERG---TASGLYNTAGSLGGALGP 344
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
11-387 |
4.85e-20 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 90.71 E-value: 4.85e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 11 VAILVFQSFLLGTSEFIIVGVLPDIASDLNIAVTMVGNLVAIFAFVYAPLTPIGAAICSKFQRFRALIALLLVFLAGNVI 90
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 91 CTFAVNYPMLLLARVVTASVSGVLVAVALTFGPDVTSRENQPRYMSWVFSGFSIASVFGMPMGTWIaGLAGWRTSFVVID 170
Cdd:cd17474 81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLL-AAISWRYPFFLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 171 VLTVVMIGVMFVVLPKRS----VPSQVGILGQFKLFSDRRIILGVLTVVFGLASSYVWYTYLTPMFTNELHVPAAYVSVA 246
Cdd:cd17474 160 ALIPVAFLAILFLLPEPKekakSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 247 LVAFGAC-CLWSNLYSGKLATRGTGIWPLVGMSKAYALqfvCMLLLPFATANAMLgSVLLVVLGLTIYLQNSPSQVLYSY 325
Cdd:cd17474 240 FAGWSVLlALGSLFVGRLLKKRFGARRILVIGLLLYAL---SLLLLGFVPSLALL-LIAIVLFGLGLGLNLPLLTTLVTE 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1539961710 326 VAETGYPGcgtLASSLNSTSCNLGIALGSAVGGVAYDAAGLRWLGPVGAVFAALAVLMTVLL 387
Cdd:cd17474 316 LAPEEERG---TASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
11-393 |
5.37e-18 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 84.54 E-value: 5.37e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 11 VAILVFQSFLLGTSEFIIVGVLPDIASDLNIAVTMVGNLVAIFAFVYAPLTPIGAAICSKFQRFRALIALLLVFLAGNVI 90
Cdd:COG2271 12 LALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 91 CTFAVNYPMLLLARVVTASVSGVLVAVALTFGPDVTSRENQPRYMSWVFSGFSIASVFGMPMGTWIAGLAGWRTSFVVID 170
Cdd:COG2271 92 FGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILG 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 171 VLTVVMIGVMFVVLpkrsvpsqvgilgqfklfsdrriilgVLTVVFGLASSYVWYTYLTPMFTNELHVPAAYVSVALVAF 250
Cdd:COG2271 172 LPGLLLALLRFWLL--------------------------ALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLP 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 251 GACCLWSNLYSGKLATRgTGIWPLVGMSKAYALQFVCMLLLPFATANAMLgSVLLVVLGLTIYLQNSpsqVLYSYVAETG 330
Cdd:COG2271 226 FLAGIVGSLLGGWLSDR-LGRRRKLVLAIGLLLAALALLLLALLPSPALA-IALLFLAGFGLGGAFG---LLWALAAELF 300
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1539961710 331 YPGCGTLASSLNSTSCNLGIALGSAVGGVAYDAAGLRWLGPVGAVFAALAVLMTVLLKVNDGR 393
Cdd:COG2271 301 PKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
14-385 |
6.78e-17 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 81.70 E-value: 6.78e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 14 LVFQSFLLGTSEFIIVGVLPDIASDLNIAVTMVGNLVAIFAFVYAPLTPIGAAICSKFQRFRALIALLLVFLAGNVICTF 93
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 94 AVNYPMLLLARVVTASVSGVLVAVALTFGPDVTSRENQPRYMSWVFSGFSIASVFGMPMGTWIA--GLAGWRTSFVVIDV 171
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 172 LTVVMIGVMFVVLPKRSVPSQVG---------ILGQFKLFSDRRIILGVLTVVFGLASSYVWYTYLTPMFTNELHVPAAY 242
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKneeassksvLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 243 VSVALVAFGACCLWSNLYSGKLATRGTGIWPLVGMSkayALQFVCMLLLPFATANAMLGSVLLVVLGLTIYLQNSpsqVL 322
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIG---LLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLP---LS 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1539961710 323 YSYVAETGYPGCGTLASSLNSTSCNLGIALGSAVGGVAYDAA-GLRWLGPVGAVFAALAVLMTV 385
Cdd:cd06174 315 FALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATfGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
18-381 |
2.77e-16 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 79.52 E-value: 2.77e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 18 SFLLGTSEFIIVGV-LPDIASDLNIAVTMVGNLVAIFAFVYAPLTPIGAAICSKFQRFRALIALLLVFLAGNVICTFAVN 96
Cdd:cd17321 4 AVFLAALDVTIVNVaLPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 97 YPMLLLARVVTASVSGVLVAVALTFGPDVTSRENQPRYMSWVFSGFSIASVFGMPMGTWIAGLAGWRTSFVVIDVLTVVM 176
Cdd:cd17321 84 LAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 177 IGVMfvvlpkrsvpsqvgilgqfklfsdRRIILGVLTVVFGLASSYVWYTYLTPMFTNELHVPAAYVSVALVAFGACCLW 256
Cdd:cd17321 164 LLLA------------------------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLV 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 257 SNLYSGKLATRGTGIWPLVGMSKAYALQFVCMLLLPFATANAMLGsVLLVVLGLTIYLQNSPSQVLYSYVAETGYPGcgt 336
Cdd:cd17321 220 AAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLL-PGLVLLGLGLGLFATPLTNAALSSVPKEKAG--- 295
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1539961710 337 LASSLNSTSCNLGIALGSAVGGVAYDAAGLRWLGPVGAVFAALAV 381
Cdd:cd17321 296 AASGILNTARQLGGALGVALLGALLTAGLSANLGDSGVAALLSAA 340
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
14-388 |
9.30e-16 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 78.02 E-value: 9.30e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 14 LVFQSFLLGTSEFIIVGVLPDIASDLNIAVTMVGNLVAIFAFVYAPLTPIGAAICSKFQRFRALIALLLVFLAGNVICTF 93
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 94 AVNYPMLLLARVVTASVSGVLVAVALTFGPDVTSRENQPRYMSWVFSGFSIASVFGMPMGTWIAGLAGWRTSFVVIDVLT 173
Cdd:cd17489 81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 174 VVMIGVMFVV-LPKRSVPSQVGILGQFKLFSDRRIILGVLTVVFGLASSYVWYTYLTPMFTNELHVpaAYVSVALVAFGA 252
Cdd:cd17489 161 LLALLLVFLVkDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGI--SNAGLFFTVYAI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 253 CCLWSNLYSGKLATRGTGIWPLVgmskAYALQFVCMLLLPFATANAMLGSVLLVVLGLTiylQNSPSQVLYSYVAETGYP 332
Cdd:cd17489 239 ALLLSRPFSGKLSDRKGPKTVII----PGLLLLALGLLLLSFAGSPWMLLLAAVLYGLG---FGLLFPALQALAVDLVPP 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1539961710 333 GCGTLASSLNSTSCNLGIALGSAVGGVAYDAAGLRWLGPVGAVFAALAVLMTVLLK 388
Cdd:cd17489 312 HRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| nepI |
PRK10213 |
purine ribonucleoside efflux pump NepI; |
21-387 |
1.65e-13 |
|
purine ribonucleoside efflux pump NepI;
Pssm-ID: 182309 [Multi-domain] Cd Length: 394 Bit Score: 71.49 E-value: 1.65e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 21 LGTSEFIIVGVLPDIASDLNIAVTMVGNLVAIFAFVYAPLTPIGAAICSKFQRFRALIALLLVFLAGNVICTFAVNYPML 100
Cdd:PRK10213 32 LIIVEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 101 LLARVVTASVSGVLVAVALTFGPDVTSRENQPRYMSWVFSGFSIASVFGMPMGTWIAGLAGWRTSFVVIDVLTVVMIGVM 180
Cdd:PRK10213 112 LIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGSFLGELIGWRNVFNAAAVMGVLCIFWI 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 181 FVVLPKRSVPSQVGILGQFKLFSDRRIILGVLTVVFGLASSYVWYTYLTPMFTNELHVPAAYVSVALVAFGACCLWSNLY 260
Cdd:PRK10213 192 IKSLPSLPGEPSHQKQNTFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIRPVYMNLAGFGVDGLTLVLLSFGIASFVGTSL 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 261 SGKLATRGTGiwplVGMSKAYALQFVCMLLLPFATANAMLGSVLLVVLGLTIYLqnspSQVLYSYVAETGYPGCGTLASS 340
Cdd:PRK10213 272 SSFILKRSVK----LALAGAPLVLAVSALVLTLWGSDKIVATGVAIIWGLTFAL----VPVGWSTWITRSLADQAEKAGS 343
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1539961710 341 LNSTSCNLGIALGSAVGGVAYDAAGLrwLGPVgaVFAALAVLMTVLL 387
Cdd:PRK10213 344 IQVAVIQLANTCGAAIGGYALDNIGL--TSPL--MLSGTLMLLTALL 386
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
3-388 |
2.92e-13 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 70.65 E-value: 2.92e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 3 SHRLFTLPVAILVFQSFLLGTSEFIIVGVLPDIASDLNIAVTMVGNLVAIFAFVYAPLTPIGAAICSKFQRFRALIALLL 82
Cdd:COG0738 2 SKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 83 VFLAGNVICTFAVNYPMLLLARVVTASVSGVLVAVALTFGPDVtSRENQPRYMSWVFSGFSIASVFGMPMGTWIAGL--- 159
Cdd:COG0738 82 LMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAAL-GPETAASRLNLLHAFFSLGALLGPLLGGLLILLgls 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 160 AGWRTSFVVIDVLTVVM-IGVMFVVLPK---RSVPSQVGILGQFKLFSDRRIILGVLTVVFGLASSYVWYTYLTPMFTNE 235
Cdd:COG0738 161 LSWHLPYLILAVLLLLLaLLFLRSKLPEieeEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 236 LHVPAAYVSVALVAFGACCLWSNLYSGKLATRGTGIWPLVGMSkayALQFVCMLLLPFATaNAMLGSVLLVVLGLTIYLQ 315
Cdd:COG0738 241 LGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSA---LLAAVGLLLALLAP-GPWLALIGLALVGLGLSLM 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1539961710 316 NSpsqVLYSYVAETGYPGCGTLASSLNSTSCnLGIALGSAVGGVAYDAAGLRWLGPVGAVFAALAVLMTVLLK 388
Cdd:COG0738 317 FP---TIFSLALDGLGKRTAAAVSAVLIMGI-VGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALK 385
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
32-356 |
7.34e-12 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 66.45 E-value: 7.34e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 32 LPDIASDLNIAVTMVGNLVAIFAFVYAPLTPIGAAICSKFQRFRALIALLLVFLAGNVICTFAVNYPMLLLARVVTASVS 111
Cdd:cd17503 19 LPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 112 GVLVAVALTFGPDVTSRENQPRYMSWVFSGFSIASVFGMPMGTWIAGLAGWRTSFVVIdvltvVMIGVMFVVLpkrsvps 191
Cdd:cd17503 99 GVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYIN-----LPIGILALLL------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 192 qvGILGQFKLFSDRRIILGVLTVVFGLASSYVWYTYLTPMFTNELHVPAAYVSVALVAFGACCLWSNLYSGKLATR-GTG 270
Cdd:cd17503 167 --APLLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKfGPR 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 271 IWPLVGMskayALQFVCMLLLPFATANAMLG--SVLLVVLGLTIYLQNSPSQVL-YSYVAETGYPgcgtLASSLNSTSCN 347
Cdd:cd17503 245 LLLLAGL----LLLALGTLLLAFLTPDTSLWliILPLFIRGLGMGLVFMPLNTLaLNSLPPEQIG----DATALFNTIRQ 316
|
....*....
gi 1539961710 348 LGIALGSAV 356
Cdd:cd17503 317 LGGSIGTAL 325
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
27-388 |
2.14e-11 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 64.51 E-value: 2.14e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 27 IIVGVLPDIASDLNiAVTMVGNLVAIFAFVYAPLTPIGAAICSKFQRFRALIALLLVFLAGNVICTFAVNYPMLLLARVV 106
Cdd:cd17502 14 IVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 107 TASVSGVLVAVALTFGPDVTSRENQPRYMSWVFSGFSIASVFGMPMGTWIAGLAGWRTSFvvidvltvvmigvmFVVLPk 186
Cdd:cd17502 93 QGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCF--------------YINLP- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 187 rsvpsqvgiLGQFKLFSDRRIILGVLTVVFGLASSYVWYTYLTPMFTNELHVPAAYVSVALVAFGACCLWSNLYSGKLAT 266
Cdd:cd17502 158 ---------IGGLALALLRTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALIS 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 267 RGTGIWPLVGMSkaYALQFVCMLLLPF--ATANAMLGSVLLVVLGLTIYLQNSPSQVLYSYVAETGYPGCGTlasSLNST 344
Cdd:cd17502 229 KTGRYKPLIVIG--TILMSVGAGLLTTltLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVAT---ATNTF 303
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1539961710 345 SCNLGIALGSAVGGVAYdaaglrwlgpVGAVFAALAVLMTVLLK 388
Cdd:cd17502 304 FRSLGGTLGVAITDVFL----------VALALAALAFLLSLFLP 337
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
11-290 |
5.58e-11 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 62.91 E-value: 5.58e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 11 VAILVFQSFLLGTSEFIIVGVLPDIASDLNIAVTMVGNLVAIFAFVYAPLTPIGAAICSKFQRFRALIALLLVFLAGNVI 90
Cdd:COG0477 16 LLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 91 CTFAVNYPMLLLARVVTASVSGVLVAVALTFGPDVTSRENQPRYMSWVFSGFSIASVFGMPMGTWIAGLAGWRTSFVVID 170
Cdd:COG0477 96 CGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINA 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 171 VLTVVMIGVMFVVLPKRSVPSQVGILGQFKLFSDRRIILGVLTVVFGLASSYVWYTYLTPMFTNELHVPAAYVSVALVAF 250
Cdd:COG0477 176 PLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLA 255
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 1539961710 251 GACCLWSNLYSGKLATRGTGIWPLVGMSKAYALQFVCMLL 290
Cdd:COG0477 256 LLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
11-363 |
9.69e-11 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 63.02 E-value: 9.69e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 11 VAILVFQSFLLGTSEFIIVGVLPDIASDLNIAVTMVGNLVAIFAFVYAPLTPIGAAICSKFQRFRALIALLLVFLAGNVI 90
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 91 CTFAVNYPMLLLARVVTASVSGVLVAVALTFGPDVTSRENQPRYMSWVFSGFSIASVFGMPMGTWIAGLA-GWRTSFVVI 169
Cdd:cd17328 81 SSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 170 DVLTVVM--IGVMFVVLPKRSVPSQVG--ILGQFKLFSDRRIILGVLTVVF----GLASSYVWY--TYLTPMFTNELHVP 239
Cdd:cd17328 161 GVLGVLLaiLLLLFVREPPRGAAEGGVmaKSTATSFLADLKALAKNPSFILstlgFTAVSFVTGalAFWAPTFFLRAFGV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 240 AAYVS--VALVAFGACC-------LWSNLYSGKLATRGTGIWPLVGMSKAYALQFVCMLLLPFATANAMLGSVLLVVLGL 310
Cdd:cd17328 241 GDLSSadVGLIFGAITCiagvlgvLLGGILADRLRRKTPRADPLVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFLGEF 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1539961710 311 TIYLQNSPSQVLYSYVAEtgyPGCGTLASSL-NSTSCNLGIALGSAVGGVAYDA 363
Cdd:cd17328 321 LLSLNWAPVFAILLYVVI---PTRRSTASAIqILLSHLLGDAGSPYLIGLISDL 371
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
9-386 |
2.25e-10 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 61.81 E-value: 2.25e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 9 LPVAILVFQSFLLGTSEFIIVGVLPDIASDLNIAVTMVGNLVAIFAFVYAPLTPIGAAICSKFQRFRALIALLLVFLAGN 88
Cdd:COG2807 18 LLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 89 VICTFAVNYPMLLLARVVTasvsGVLVAVALTFGPDVTSR---ENQPRYMSWVFSGFSIASVFGMPMGTWIAGLAGWRTS 165
Cdd:COG2807 98 LLRSLAPSVALLLAGTALI----GAGIAVGNVLLPGLIKRwfpDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGA 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 166 FVVIDVLTVVMIGVMFVVLPKRSVPSQVGILGQFKLFSDRRIILGVLTVVFGLASS--YVWYTYLTPMFTnELHVPAAYV 243
Cdd:COG2807 174 LAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLlyYAVVAWLPPILR-DAGLSAATA 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 244 SVALVAFGACCLWSNLYSGKLATRGTGIWPLVGMskAYALQFVCMLLLPFATANAMLGSVLLVVLGLTIylqnSPSQVLY 323
Cdd:COG2807 253 GLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLL--LGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGG----LFPLALT 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1539961710 324 SYVAETGYPGCGTLASSLNSTSCNLGIALGSAVGGVAYDAAGlRWlGPVGAVFAALAVLMTVL 386
Cdd:COG2807 327 LIGLRARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDATG-SW-TAALLLLAALAVLMLVA 387
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
11-387 |
2.43e-09 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 58.74 E-value: 2.43e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 11 VAILVFQSFLLGTSEFIIVGVLPDIASDLNIAVTMVGNLVAIFAFVYAPLTPIGAAICSKFQRFRALIALLLVFLAGNVI 90
Cdd:cd17323 1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 91 CTFAVNYPMLLLARVVTA-SVSGVLVAVALTFGpDVTSRENQPRYMSWVFSGFSIASVFGMPMGTWIAGLAGWRTSFVVI 169
Cdd:cd17323 81 CALAPNIAMLIILRFLQGfFGSSPLAIGAGTIA-DLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 170 DVLTVVMIGVMFVVLPkrsvpsqvgILGQFKLFSDrrIILGVLTVVFGlASSYVWYtylTPMFTNELHVPAAYVSV---A 246
Cdd:cd17323 160 AIISGFCLILIFLFLP---------IVLLLGLYVG--LVYAILYLFLT-AFPYVFG---EVYGFSPGEVGLMYLPIgigA 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 247 LVAFGACCLWSNLYSGKLATRGTGIWP----LVGMSKAYALQFVCMLLLPFATANAMLGSVLLVVLGLTIYLQNSPSQVL 322
Cdd:cd17323 225 LIGSIIGGRLSDYYYRRLKKKNGGKPEpearLPPAFIGAFLFPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSS 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1539961710 323 YSYVAETgYPGCGTLASSLNSTSCNLGIALGSAVGGVAYDAAGLRWLGPVGAVFAALAVLMTVLL 387
Cdd:cd17323 305 LTYLVDS-YPKYAASALAANTLVRSIFAAIFPLFAQPMFNNLGVGWAFTLLAFISLAMIPIPFIF 368
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
14-388 |
3.89e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 57.97 E-value: 3.89e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 14 LVFQSFLLGTSEFIIVGVLPDIASDLNIAVTMVGNLVAIFAFVYAPLTPIGAAICSKFQRFRALIALLLVFLAGNVICTF 93
Cdd:cd17504 1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 94 AVNYPMLLLARVVTAsVSGVLVAVALTFGPDVTSRENQPRYMSWVFSGFSIASVFGMPMGTWIAGLAGWRTSFVVIDVLT 173
Cdd:cd17504 81 APNLPVLIAGRALQG-IGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 174 VVMIGVMFVVLPKRSVPSQVGILGQFKLFSDRRIILGVLTVVFGLASSYVWYTYLTPMFTNELHVPAAYVSVALVAFgac 253
Cdd:cd17504 160 VLLAALVPLIDLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLLLLPGALVMLIAGPL--- 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 254 clwsnlySGKLATRGTGIWPLVGMSKAYALQFVCMLLLPFATAnAMLGSVLLVVLGLTIYLQNSPSQVLYSyvAETGYPG 333
Cdd:cd17504 237 -------AGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLW-ALVVALLLIGIGLGLAFASLPNIVVES--VPPDRTG 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1539961710 334 cgtLASSLNSTSCNLGIALGSAVGGV---AYDAAGLRWLGP----------VGAVFAALAVLMTVLLK 388
Cdd:cd17504 307 ---IATGMNTVLRTIGSAIGPAIAGAiltTYTVSITSGGVPtegayvlaflIGAALALAALLLSLLIP 371
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
67-388 |
8.96e-09 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 56.84 E-value: 8.96e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 67 ICSKFQRFRALIALLLVFLAGNVICTFAVNYPMLLLARVVTAsvSGVLVAVALTFGPDVTSRENQPRYMSWVFSGFSIAS 146
Cdd:cd17472 55 LSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQG--SGAISSVVMALLADLTREENRTKAMALIGASIGIAF 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 147 VFGMPMGTWIAGLAGWRTSFVVIDVLTVVMIGVMFVVLP--KRSVPSQVGILGQFKLFSDRRIILGVLTVVFGLASSYVW 224
Cdd:cd17472 133 AISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPdpPKIVQISEKEKKKLKKLLKNKRLLRLDFSIFILHFVLMA 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 225 YTYLTPMFTNELHVPAA-----YVSVALVAFGACCLwsnlySGKLATRGTGIWPLVGMSkayalqfVCMLLLPFATANAM 299
Cdd:cd17472 213 FFYILPLLLTQLGGGKGqlwkvYLPAILIGFILMVP-----FVIYAEKKGKMKQVFVSS-------ILLIAVGFLLLLFA 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 300 LGSVLLVVLGLTIYLQ--NSPSQVLYSYVAETGYPGCGTLASSLNSTSCNLGIALGSAVGGVAYDAAGLRWLGPVGAVFA 377
Cdd:cd17472 281 ATSLWLLIIGLIIFFIgfNLLEALLPSLVSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILILA 360
|
330
....*....|.
gi 1539961710 378 ALAVLMTVLLK 388
Cdd:cd17472 361 LLWLLVSFLLP 371
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
70-383 |
1.45e-08 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 56.02 E-value: 1.45e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 70 KFQRFRALIALLLVFLAGNVICTFAVNYPMLLLARVVTASVSGVLVAVALTFGPDV---TSRENQPRYMSWVFSGFSIAS 146
Cdd:cd17471 59 GGDRKPLILLALLAGALGYLLFAFLRNYWVLLLVGVVLLSLGAAAFPQLFALAREYadrSSGRDATLFNSVLRAAFSLAW 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 147 VFGMPMGTWIAGLAGWRTSFVVIDVLTVVMIGVMFVVLPKRSVPSQVG--ILGQFKLFSDRRIILGVLTVVFGLASSYVW 224
Cdd:cd17471 139 VIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVKPPAQKAtpASSLVKAPVNRRLLLLFAAFTLLFAANSMY 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 225 YTYLTPMFTNELHVPAAYVSVALVAFGACCLWSNLYSGKLATRGTGIWPLVGMSKAYALQFVCMLLLP----FATANAML 300
Cdd:cd17471 219 IIAMPLYVTNELGGSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATslwqLIALQLLN 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 301 GSVLLVVLGLTI-YLQNSpsqvlysyvaetgYPGCGTLASSLNSTSCNLGIALGSAVGGVAYDAAGLRWLGPVGAVFAAL 379
Cdd:cd17471 299 AIFIGITAGLGIsYFQDL-------------MPGQPGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALL 365
|
....
gi 1539961710 380 AVLM 383
Cdd:cd17471 366 ALVL 369
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
39-395 |
1.50e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 56.45 E-value: 1.50e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 39 LNIAVTMVGNLVAIFAFVYAPLTPIGAAIC----SKFQRFRALIALLLVFLAGNVICTFAVnYPMLLLARVVTASVSGVL 114
Cdd:COG2211 41 LGLSAALVGLILLVARLWDAITDPLIGALSdrtrTRWGRRRPWILIGAIPLALSFVLLFTA-PDLSPTGKLIYALVTYLL 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 115 VAVALTF--------GPDVTSRENQ-PRYMSWVFSGFSIASVFGMPMGTWIAGL------AGWRTSFVVIDVLTVVMIGV 179
Cdd:COG2211 120 LGLAYTLvnipysalGAELTPDYEErTRLSSWRFAFAGLGGLLASVLPPPLVAAfggdaaLGYRLTALIFAVLGLLAFLL 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 180 MFVVLPKRSVPSQ--VGILGQFK-LFSDRRIILGVLTVVFGLASSYVWYTYLTPMFTNELHVPAAYVSVALVAFGACCLW 256
Cdd:COG2211 200 TFFGTKERPVPEEekVSLKESLKaLLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALL 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 257 SNLYSGKLATRGTGIWPLVGMSKAYALQFVCMLLLPFATANAMLGSVLLVVLGLTIYLQNSPSqvLYSYVAETGYPGCGT 336
Cdd:COG2211 280 GAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWA--MLADVVDYDEWKTGR 357
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1539961710 337 ----LASSLNSTSCNLGIALGSAVGGVAYDAAGLR---------------WLGPVGAVFAALAVLMTVLLKVNDGRRA 395
Cdd:COG2211 358 rregLYFGIFTFAIKLGQALAGALAGLLLALFGYVagaaqspsaltgirlLFFLLPAVLLLLAALLLLFYPLTRERHA 435
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
19-382 |
1.88e-08 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 55.66 E-value: 1.88e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 19 FLLGTSEFIIVGVLPDI---ASDLNIAVTMVGNLVAIFAFVYAPLTPIGAAICSKFQRFRALIALLLVFLAGNVICTFAV 95
Cdd:cd17330 6 FLDALGFGIVFPVLPFYvreFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 96 NYPMLLLARVVTASVSGVlVAVALTFGPDVTSRENQPRYMSWVFSGFSIASVFGMPMGTWIAGLAGWRTSFVVIDVLTVV 175
Cdd:cd17330 86 NLWLLFLARFLDGLTGGN-VSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 176 MIGVMFVVLPKRSVPSQVGILGQFklfsdrriILGVLTVVFGLASSYVwytyltpmftneLHVPAAYVSVALVAFG-ACC 254
Cdd:cd17330 165 NLVLVLFFLPPLRRLLLVYFLIAL--------AFAGLESVFSLFLKDR------------FGFSPSQIGLLLALVGiAGI 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 255 LWSNLYSGKLATRGTGIWPLVGMSKAYALQFVCMLLLPFATANAMLGSVLLVVLGLTiylqnspSQVLYSYVAETGYPGC 334
Cdd:cd17330 225 LAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIV-------FPALSALLSKSVPSKE 297
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1539961710 335 GTLASSLNSTSCNLGIALGSAVGGVAYDAAGLRWLGPVGAVFAALAVL 382
Cdd:cd17330 298 QGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALF 345
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
32-186 |
6.20e-08 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 54.11 E-value: 6.20e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 32 LPDIASDLNIAVTMVGNLVAIFAFVYAPLTPIGAAICSKFQRFRALIALLLVFLAGNVICTFAVNYPMLLLARVVT---- 107
Cdd:cd17319 26 APTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLgvae 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 108 -ASVSGVLVAVALTFgpdvtSRENQPRYMSWVFSGFSIASVFGMPMGTWIAGLAGWRTSFVVIDVLTVVMIGVMFVVLPK 186
Cdd:cd17319 106 aGFFPGAIKALAEWF-----PARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQ 180
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
30-384 |
1.47e-07 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 53.04 E-value: 1.47e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 30 GVLPDIASDLNIAVTMVGNLVAIFAFVYAPLTPIGAAICSKFQRFRALIALLLVFLAGNVICTFAVNYPMLLLARVV--- 106
Cdd:cd17355 24 VFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLlgg 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 107 --TASVSGVLVAVALTFGPDvtsrENQPRYMSWVFSGFSIASVFGMPMGTWIAGLAGWRTSFVVIDVLTVVMIGVMFVVL 184
Cdd:cd17355 104 ggAGTLAAVAFATVAAWWFE----RRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLL 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 185 PKRSVPSQVGILGQ----------FKLFSDRRIILGVLTVVFGLASSYVWYTYLTPMFTnELHVPAAYVSVALVAFGACC 254
Cdd:cd17355 180 RRRPADLALRAYDDaspaspgstlKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLA-DRGISPAAAAVALALIGLFN 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 255 LWSNLYSGKLATRGTGIWPLVGmskAYALQFVCMLLLPFATANAMLGSVLLVVLGLTIYLQNSPSQVLysyVAETGYPGC 334
Cdd:cd17355 259 IVGRLLSGWLGDRYSPRRLLAA---SYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLTAAL---AARYFGARS 332
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1539961710 335 GTLASSLNSTSCNLGIALGSAVGGVAYDAAG----LRWLGPVGAVFAALAVLMT 384
Cdd:cd17355 333 YGTLFGLVFAPHQLGSALGPWLGGLLYDRTGsytaAWALAVALGLIAALLVLPI 386
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
13-386 |
1.70e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 52.96 E-value: 1.70e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 13 ILVFQSFLLGTSEFIIVGVLPDIASD-LNIAVTMVGNLVAIFAFVYAPLTPIGAAICSKFQRFRALIALLLVFLAGNVIC 91
Cdd:cd17473 3 TLLLASTLTVMAGAAIAPALPAIAQHfVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 92 TFAVNYPMLLLARVVTASVSGVLVAVALTFGPDVTSRENQPRYMSWVFSGFSIASVFGMPMGTWIAGLaGWRTSFVVIDV 171
Cdd:cd17473 83 LFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI-GWRAPFLVYLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 172 LTVVMIGVMFVV--LPKRSVPSQVGILGQFKLFSDRRIILGVLTVVFGLASSYVWYTYLTPMFTNELHVPAAYVSVALVA 249
Cdd:cd17473 162 ALPVLILVLLFLpePARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 250 FGACCLWSNLYSGKLATRGTGIWPLVGMSKAYALQFVCMLLLPFATanAMLGSVLLVVLGLTIYLQNspsqvLYSYVAET 329
Cdd:cd17473 242 ASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLW--VVLLGAILAGLGFGLLLPT-----LNSWAMSL 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1539961710 330 GYPGCGTLASSLNSTSCNLGIALGSAVGGVAydaagLRWLGPVGAVFAALAVLMTVL 386
Cdd:cd17473 315 VPPELRGRAMGIVTSAFFLGQFLSPLVLGPL-----VNLTGGLSGAFLILGVLALVL 366
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
31-185 |
1.71e-07 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 52.74 E-value: 1.71e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 31 VLPDIASDLNIAVTMVGNLVAIFAFVYAPLTPIGAAICSKFQRFRALIALLLVFLAGNVICTFAVNYPMLLLARVVTASV 110
Cdd:TIGR00895 39 AAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLG 118
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1539961710 111 SGVLVAVALTFGPDVTSRENQPRYMSWVFSGFSIASVFGMPMGTWIAGLAGWRTSFVVIDVLTVVMIGVMFVVLP 185
Cdd:TIGR00895 119 LGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLP 193
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
75-387 |
3.67e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 51.85 E-value: 3.67e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 75 RALIALLLVFLAGnvicTFAVNYPMLLLARVVTASVSGVLVAVALTFGPDVTSRENQPRYMSWVFSGFSIASVFGMPMGT 154
Cdd:cd06173 74 RALLAAVLALLAL----LGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGG 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 155 WIAGLAGWRTSFVVIDVLTVVMIGVMF--------VVLPKRSVPSQVGILGQFKLFSDRRIILGVLTVVFGLASSYVWYT 226
Cdd:cd06173 150 LLVALLGPGGAFAINALSFLLSALLLLfirrpppaAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTV 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 227 YLTPMFTNELHVPAAYVSVALVAFGACCLWSNLYSGKLATRGTgiwPLVGMSKAYALQFVCMLLLPFATaNAMLGSVLLV 306
Cdd:cd06173 230 LLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRR---RGRLLLIGALLLGLALLVLGLSP-SLWLLLAALF 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 307 VLGLTIYLQNSPSQVLYSYVAETGYPGcgtLASSLNSTSCNLGIALGSAVGGVAYDAAGLRWLGPVGAVFAALAVLMTVL 386
Cdd:cd06173 306 LLGLAGGLFNVPLNTLLQLRVPDELRG---RVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
.
gi 1539961710 387 L 387
Cdd:cd06173 383 L 383
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
18-296 |
3.97e-06 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 48.37 E-value: 3.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 18 SFLLGTSEFIIVGVLPDIASDLNIAVTMVGNLVAIFAFVYAPL-TPIGAAICSKFQRFRALIALLLVFLAGNVICTFAVN 96
Cdd:cd17490 5 VFLFWFSQYVYVPFLSPYAESLGASLSMIGIILGAYGISQMLLrIPLGILSDRIGKRKLFIIIGLLFTVLASLIMILFPS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 97 YPMLLLARVVTASVSGVLVAVALTFGpDVTSRENQPRYMSWVFSGFSIASVFGMPMGTWIAGLAGWRTSFVVIDVLTVVM 176
Cdd:cd17490 85 PWGLLIARFLSGIAAATWVSFTVLYA-SYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 177 IGVMFVVLPKRSVPSQVGILGQ--FKLFSDRRIILGVLTVVFGLASSYVWYTYLTPMFTNELHVPAAYVSVALVAFGACC 254
Cdd:cd17490 164 FILSLFIKEERREKKPVLTELKelLSVLKDKKLLFFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPN 243
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1539961710 255 LWSNLYSG-----KLATRGTGIWplvgmskAYALQFVCMLLLPFATA 296
Cdd:cd17490 244 ALASLLSGtlfykKLGERNTIII-------GFLLLGAYCFLIPFAPN 283
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
27-185 |
4.66e-06 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 48.40 E-value: 4.66e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 27 IIVGVLPDIASDLNIAVTMVGNLVAIFAFVYAPL----TPIGAAICSKFQRFRALIALLLVFLAGNVICTFAVNYPMLLL 102
Cdd:cd17388 17 LIMPVLPTLLREFVGDSADAATHYGVLLALYALMqfifAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 103 ARVVtASVSGVLVAVALTFGPDVTSRENQPRYMSWVFSGFSIASVFGMPMGTWIAGLaGWRTSFVVIDVLTVVMIGVMFV 182
Cdd:cd17388 97 GRII-AGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEI-SPRAPFLVAAGLNGLNFLLGLF 174
|
...
gi 1539961710 183 VLP 185
Cdd:cd17388 175 VLP 177
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
26-328 |
5.76e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 47.98 E-value: 5.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 26 FIIVGVLPDIASDLN--IAVTMVGNLVAIFAFVYAPLTPIGAAICSKFQRFRALIALLLVFLAGNVICTFAVNYPMLLLA 103
Cdd:cd17316 16 FLIGFVAPVLAAEFSlgLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 104 RVVTASVSGVLVAVALTFGPDVTSRENQPRYMSWVFSGFSIASVFGMPMGTWIAGLA----GWRTSFVVidvltvvmigv 179
Cdd:cd17316 96 RFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLsgdwGWRILFLI----------- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 180 mfvvlpkrsvpsqVGILGQFKLFSDRRIILGVLTVVFGLASSYVWYTYLTPMFTNELHVPAAYVSVALVAFGACCLWSNL 259
Cdd:cd17316 165 -------------GALPALLALLLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGAL 231
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1539961710 260 YSGKLATRgtgiwplVGMSKAYALQFVCMLLLPFATANAMLGSVLLVVLGLTIY--LQNSPSQVLYSYVAE 328
Cdd:cd17316 232 IAGLLSDR-------IGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILsfFVGGVWGALYAYLAE 295
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
149-382 |
1.23e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 43.77 E-value: 1.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 149 GMPMGT--------WIAGLAGWRTSFVVIDVLTVVMIGVMFVVLPKRSVPSQVGILGQFKLFS------DRRIILGVLTV 214
Cdd:cd17475 128 GVPLGGalaaallpPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPAASAATESASTLLRSlkevlrNRDVWLIAIAG 207
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 215 VFGLASSYVWYTYLTPMFTNELHVP----AAYVSVALVAFGACCLWSNLYSGKLaTRGTGIWPLVGMSKAYALQFVCMLL 290
Cdd:cd17475 208 ALLVAPQFALLTFLLLFLHDHLGLSvvaaGALLAVAQLGGALGRIGLGRVSDRV-FGGRRRPVLVITAAIAAAALLVLSL 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 291 LPFATANAMLGSvLLVVLGLTIYLQNSPSqvlYSYVAETGYPGCGTLASSLNSTSCNLGIALGSAVGGVAYDAAG---LR 367
Cdd:cd17475 287 LSPGTPLWLLVL-LLILLGLFAIGWNGLY---LTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHsyaPA 362
|
250
....*....|....*
gi 1539961710 368 WLGPVGAVFAALAVL 382
Cdd:cd17475 363 WLALALLLVLAALLL 377
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
13-382 |
1.28e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 43.76 E-value: 1.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 13 ILVFQSFLLGTSEFIIVGVLPD-IASDLNIAVTMVGNLVAIFAFVYAPLTPIGAAICSKFQRFRALIALLLVFLAGNVIC 91
Cdd:cd17329 3 VLLIGSFLNRLGFFMVWPFMAIyLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 92 TFAVNYPMLLLARVVTASVSGVLVAVALTFGPDVTSRENQPRYMSWVFSGFSIASVFGMPMGTWIAGLaGWRTSFVVIDV 171
Cdd:cd17329 83 GFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLAAAV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 172 LTVVMIGVMFVVLPKRSVPSQVGILGQFK-----LFSDRRIILGVLTVVFGLASSYVWYTYLTPMFTNELHVPAAYVSVA 246
Cdd:cd17329 162 LFLLAALVLLFLLPETRPKRRAAEKTEILrgykiVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 247 LVAFGACCLWSNLYSGKLATRGTgiwPLVGMSKAYALQFVCMLLLPFATANAML-GSVLLVVLGLTIYLQNSPsqvlySY 325
Cdd:cd17329 242 LALNALLIVLLQFPVARLVERFR---LRKILMIGILLFAIGFAVLAFANTLAVLiLAMIVLTLGEMLVFPAVQ-----TL 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1539961710 326 VAETGYPGCGTLASSLNSTSCNLGIALGSAVGGVAYDAAGLRWLGPVGAVFAALAVL 382
Cdd:cd17329 314 VAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAA 370
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
38-387 |
1.51e-04 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 43.73 E-value: 1.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 38 DLNIAVTMVGNLVAIFAFVYAPLTPIGAAICSKFQRFRALI--ALLLVFLAGNVICTFAVNYPMLLLARVVTASVSGVLV 115
Cdd:cd17335 26 QLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLllSLLAAVLFFLSLFFVAQIFWLLLLLVILGAFFSAPVV 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 116 AV--ALTFGPDVTSRENQPRYMSWVFSGFSIASVFGMPMGTWIAGLAGWRTSFVVIDVL-TVVMIGVMFVVLPKRSVPSQ 192
Cdd:cd17335 106 PLvdSITLQYLGEERERYGKQRLWGSIGFGIAALLVGILIDRSSTYKNYTIAFYVFAVLmLLALLLALKFPFRPKHPEPN 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 193 VGILGQFKLFSDRRIILGVLTVVFGLASSYVWYTYLTPmFTNELHVPAAYVSVALVAFGACCLWSNLYSGKLATRgtgiW 272
Cdd:cd17335 186 ENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSFLFW-HLQDLGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQR----F 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 273 PLVGMSKAYALQFVCMLLLPFATANAMLGSVLLVVLGLTIYLQNSPSqvlYSYVAETGYPGCGTLASSLNSTSCN-LGIA 351
Cdd:cd17335 261 GHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAA---VSYASAAAPPGLRATAQGLLQGLYFgLGGG 337
|
330 340 350
....*....|....*....|....*....|....*.
gi 1539961710 352 LGSAVGGVAYDAAGLRWLGPVGAVFAALAVLMTVLL 387
Cdd:cd17335 338 LGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLI 373
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
32-316 |
1.64e-04 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 43.52 E-value: 1.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 32 LPDIASDLNIAVTMVGNLVAIFAFVYAPLTPIGAAICSKFQRFRALIALLLVFLAGNVICTFAVNYPMLLLARVVTASVS 111
Cdd:TIGR00711 25 IPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFGG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 112 GVLVAVALTFGPDVTSRENQPRYMSWVFSGFSIASVFGMPMGTWIAGLAGWRTSFVVIDVLTVVMIGVMFVVLPKRSVPS 191
Cdd:TIGR00711 105 GPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVVAFFILPRDKPAA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 192 QVgilgQFKLFSDRRIILGVLTVVFGLASSyvwyTYLTPMFTNELHVPAAYVSVALVAFgacclwsnlysgkLATRGTGI 271
Cdd:TIGR00711 185 SE----NFDFLGLLLLSVGLGSLLYGLSEG----PERGWFDSNEILILSITGLVAIIAF-------------VVWELTDD 243
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 1539961710 272 WPLVGMS----KAYALQFVCMLLLPFatanAMLGSVLLvvlgLTIYLQN 316
Cdd:TIGR00711 244 NPLVDLRlfkyRNFTIGCVYMSLLGL----GLYGSFYL----LPLYLQQ 284
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
27-385 |
1.95e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 43.31 E-value: 1.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 27 IIVGVLPDIASDLNIAVTMVGNLVAIFAFVYAPLTPIGAAICSKFQRFRALIALLLVFLAGNVICTFAVNYPMLLLArvv 106
Cdd:cd17478 14 FLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLL--- 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 107 tASVSGVLVAVALTFGPDVTSR---ENQPRYMSWVFSGFSIASVFGMPMGTWIAGLAGWRTSFVVIDVLTVVMIGVMFVV 183
Cdd:cd17478 91 -VALAGIGSAAFHPEGARLASQaagGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 184 LPKRSvPSQVGILGQFKLFSDRRIILGVLTVVFGLASSYVWY-----TYLTPMFTnELHVPAAYVSVALVAFGACCLWSN 258
Cdd:cd17478 170 RPLKK-PEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVlssltTFLPFYLV-QRGYSLVFAGLLLSLFLFAGAIGT 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 259 LYSGKLATRgtgIWPLVGMSKAYALQFVCMLLLPFATANAMLgsVLLVVLGLTIYLQNSPSQVLysyvAETGYPGCGTLA 338
Cdd:cd17478 248 LIGGPLSDR---FGRRRVIIASLLLAAPFLLLFLLTPGIWSY--ILLVLAGFLLFASFPVTVVL----AQELLPGNVGLA 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1539961710 339 SSLNSTSCNLGIALGSAVGGVAYDAAGLRWLGPVGAVFAALAVLMTV 385
Cdd:cd17478 319 SGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
19-188 |
2.87e-04 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 42.59 E-value: 2.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 19 FLLGTSEFIIVGVLPDIASDLNIAVTMVGNLVAIFAFVYApltpIGAAICSKF-QRFRALIALLLVFLAGNVICT---FA 94
Cdd:cd17331 10 VLYATCYWLQQPVLPYLTKKLGVDSVVFGYLQTTFSVLQL----VGGPLFGRFgDLFGPRAALVLSFLSSALSYLllaFA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 95 VNYPMLLLARVVTASVSGVLVAVALTfgPDVTSRENQPRYMSWVFSGFSIASVFGMPMGTWIAGLAGWRTSFVVIDVLTV 174
Cdd:cd17331 86 SSVPMLFLSRLPSVFMHAMQAAQMVV--TDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSL 163
|
170
....*....|....
gi 1539961710 175 VMIGVMFVVLPKRS 188
Cdd:cd17331 164 LSIVLVILLIPSNT 177
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
13-193 |
3.14e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 42.56 E-value: 3.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 13 ILVFQSFLLGTSEFIIVGVLPDIASD-LNIAVTMVGNLVAIFAFVYAPLTPIGAAICSKFQRFRALIALLLVFLAGNVIC 91
Cdd:COG2223 209 LLSLLYFGTFGSFIGFSSWLPPYLVDqFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLL 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 92 TFAV-NYPMLLLARVVTASVSGVLVAVALTFGPDVTSRENQPRYMSWVFSGFSIASVFGMPMGTWIAGLAG-WRTSFVVI 169
Cdd:COG2223 289 ALALgSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVF 368
|
170 180
....*....|....*....|....
gi 1539961710 170 DVLTVVMIGVMFVVLPKRSVPSQV 193
Cdd:COG2223 369 AVLALVALVLTLLLYRRPRRAAAA 392
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
31-184 |
3.29e-04 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 42.57 E-value: 3.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 31 VLPDIASDLNIAVTMVGNLVAIFAFVYAPLTPIGAAICSKFQRFRALIALLLVFLAGNVICTFAVNYPMLLLARVVTASV 110
Cdd:cd17365 21 VAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLG 100
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1539961710 111 SGVLVAVALTFGPDVTSRENQPRYMSWVFSGFSIASVFGMPMGTWIAGLAGWRTSFVVIDVLTVVMIGVMFVVL 184
Cdd:cd17365 101 LGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLLRGTL 174
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
27-219 |
7.01e-04 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 41.43 E-value: 7.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 27 IIVGVLPDIASDLNIAVTMVGNLVA-------IFAFVYAPLTpigaaicSKFQRFRALIALLLVFLAGNVICTFAVNYPM 99
Cdd:PRK11652 26 IYVPAIADMARDLNVREGAVQAVMAaylltygLSQLFYGPLS-------DRVGRRPVILVGMSIFILGTLVALFAHSLTV 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 100 LLLARVVTASVSGVLVAVALTFGPDVTSRENQPRYMSWVFSGFSIASVFGMPMGTWIAGLAGWRTSFVVIDVLTVVMIGV 179
Cdd:PRK11652 99 LIAASAIQGLGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLGAGVTFS 178
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1539961710 180 MFVVLPKrSVPSQV---GILGQFK-LFSDRRIILGVLTVVFGLA 219
Cdd:PRK11652 179 MARWMPE-TRPADArrtRVLASYRtLLSNRRFNCYLLMLIGTLA 221
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
26-183 |
1.13e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 41.01 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 26 FIIVGVLPDIASDLNIAVTMVGNLVAIFAFVYAPLTPIGAAICSKFQRFRALIALLLVFLAGNVICTFAVNYPMLLLARV 105
Cdd:COG2807 232 YAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAV 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 106 VTASVSGVLVAVALTFGPDVTSRENQ-PRYMSWVFSGFSIASVFGMPMGTWIAGLAG-WRTSFVVIDVLTVVMIGVMFVV 183
Cdd:COG2807 312 LLGLGQGGLFPLALTLIGLRARTPAEaAALSGMAQSVGYLLAALGPLLVGALHDATGsWTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
14-312 |
1.17e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 40.62 E-value: 1.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 14 LVFQSFLLGTSEFIIVGVLPDIASDLNIAVTMVGNLVAIFAFVYAPLTPIGAAICSKFQRFRALIALLLVFLAGNVICTF 93
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 94 AVNYPMLLLARVVTASVSGVLVAVALTFGPDVTSRENQPRYMSWVFSGFSIASVFGmPMGTWIAGLAGWrTSFVVIDVLT 173
Cdd:cd17477 81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALG-PLLLALVGTAGA-LPFLIAAVLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 174 VVMIGVMFVVLPKRSVPSQVGILGQFKLFsdRRIILGVL-TVVFGLASSYVWytYLTPMFTNELHVPAAYVSVALVAFGA 252
Cdd:cd17477 159 LLALVPLLLTRRAAPEIEEAESISLRRLL--RIAPLALLgAFVAGFLEGAFY--SLLPLYGLRLGLSVAQAALLLAAFVL 234
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 253 CCLWSNLYSGKLATRGTGIWPLVGMSkayALQFVCMLLLPFATANAMLGSVLLVVLGLTI 312
Cdd:cd17477 235 GGLLLQWPLGWLADRFDRRRVLLGCA---LLGALAALLLPLVPGLPLALLVLLFLWGGAA 291
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
46-157 |
2.10e-03 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 39.95 E-value: 2.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 46 VGNLVAIFAFVYAPLTpigAAICSKFQRFRALIALLLVFLAGNVICTFAVNYPMLLLARVVtASVSGVLVAVALTFGPDV 125
Cdd:cd17389 69 IGSLFSLLQFLSSPIT---GAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIV-GGISKGNVSLSTAIVADV 144
|
90 100 110
....*....|....*....|....*....|..
gi 1539961710 126 TSRENQPRYMSWVFSGFSIASVFGMPMGTWIA 157
Cdd:cd17389 145 TSPKKRSKGMALIGVAFSLGFIIGPMIGAYFA 176
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
16-312 |
4.31e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 38.84 E-value: 4.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 16 FQSFLLGTSEFIIVGVLPDIASDLNIAVTMVGNLVAIFAFVYAPLTPIGAAICSKFQRFRALIALLLVFLAGNVICTFAV 95
Cdd:cd17333 3 ISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 96 NYPMLLLARVVTASVSGVLVAVALTFGPDVtSRENQPRYMSWVFSGFSIASVFGMPMGTW-IAGLAGWRTSFVVIDVLTV 174
Cdd:cd17333 83 SIYLFVVLMFLAGLGAGILDTGANTFVGAL-FEESSATRLNVLHGFFGLGALIGPLIATSlLTSELSWSWAYLIIGLIYL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 175 -VMIGVMFVVLPKRSVPSQVGILGQ------FKLFSDRRIILGVLTVVFGLASSYVWYTYLTPMFTNELHVPAAYVSVAL 247
Cdd:cd17333 162 lLAILILLTLFPELPSARNPQQSVGafsasaSRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLL 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1539961710 248 VAFGACCLWSNLYSGKLATRgTGIWPLVGMSKAYALQFVCMLLLpfaTANAMLGSVLLVVLGLTI 312
Cdd:cd17333 242 SGFWVGITIGRLLGGPISRR-IKPHTLLVLSGSGALLGLLILLL---APTLVVGLVATALLGLFM 302
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
31-177 |
7.78e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 38.05 E-value: 7.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539961710 31 VLPDIASDLNIAVTMVGNLVAIFAFVYAPLTPIGAAICSKFQRFRALIALLLVFLAGNVICTFAVNYPMLLLARVVTASV 110
Cdd:cd17371 21 VLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLG 100
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1539961710 111 SGVLVAVALTFGPDVTSRENQPRYMSWVFSGFSIASVFGMPMGTWIAGLA----GWRTSFV--VIDVLTVVMI 177
Cdd:cd17371 101 FGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLppeiAWRVLFLlgALPALLVLFI 173
|
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