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Conserved domains on  [gi|1539804673|emb|VEE66314|]
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Multidrug resistance protein MdtH [Staphylococcus schweitzeri]

Protein Classification

MDR family MFS transporter( domain architecture ID 13023665)

MDR (multi-drug resistance) family major facilitator superfamily (MFS) transporter confers resistance to specific drugs/toxins through their active efflux from the cell

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020
PubMed:  26758938|26098515|27052334|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 7-381 9.86e-94

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 285.66  E-value: 9.86e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673   7 VWWLVIGMALNITGSSFLWPLNTIYMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCSTT 86
Cdd:cd17329     1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  87 LLNFFHGWPWYAVWLVMLGFGGGMIIPAIYAMAGAVWPNGGRQ-TFNAIYLAQNIGVAVGAAMGGFVAEFSFNYIFLANL 165
Cdd:cd17329    81 LLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTrAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 166 IMYIVFALVAITQFNIEIKAKVKYPTHLDITGKKNKARFISLVLICAMFAICWVAYIQWESTIASF-TQSINISMAQYSV 244
Cdd:cd17329   161 VLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYvVEILGLGESLLGL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 245 LWTINGIMILVAQPLIKPilYLLKGDLKKQMFVGIVIFMLSFFVTSFAENFTIFVVGMIILTFGEMFVWPAVPTIANQLA 324
Cdd:cd17329   241 LLALNALLIVLLQFPVAR--LVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALA 318

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1539804673 325 PEGKQGQYQGFVNSAATVGKAFGPFLGGVLVDAFNMRMMFIGMMVLLVFALILLMIF 381
Cdd:cd17329   319 PPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGL 375
 
Name Accession Description Interval E-value
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 7-381 9.86e-94

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 285.66  E-value: 9.86e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673   7 VWWLVIGMALNITGSSFLWPLNTIYMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCSTT 86
Cdd:cd17329     1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  87 LLNFFHGWPWYAVWLVMLGFGGGMIIPAIYAMAGAVWPNGGRQ-TFNAIYLAQNIGVAVGAAMGGFVAEFSFNYIFLANL 165
Cdd:cd17329    81 LLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTrAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 166 IMYIVFALVAITQFNIEIKAKVKYPTHLDITGKKNKARFISLVLICAMFAICWVAYIQWESTIASF-TQSINISMAQYSV 244
Cdd:cd17329   161 VLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYvVEILGLGESLLGL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 245 LWTINGIMILVAQPLIKPilYLLKGDLKKQMFVGIVIFMLSFFVTSFAENFTIFVVGMIILTFGEMFVWPAVPTIANQLA 324
Cdd:cd17329   241 LLALNALLIVLLQFPVAR--LVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALA 318

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1539804673 325 PEGKQGQYQGFVNSAATVGKAFGPFLGGVLVDAFNMRMMFIGMMVLLVFALILLMIF 381
Cdd:cd17329   319 PPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGL 375
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
5-343 2.38e-27

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 110.83  E-value: 2.38e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673   5 KSVWWLVIGMALNITGSSFLWPLNTiYMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCS 84
Cdd:COG2814    10 LALLALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  85 TTLLNFFHGWPWYAVWLVMLGFGGGMIIPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVAVGAAMGGFVAE-FSFNYIFL 162
Cdd:COG2814    89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLgAGLGLGPALGPLLGGLLADlFGWRWVFL 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 163 ANLIMYIVFALVAITQFNiEIKAKVKYPTHLDITGKKNKARFISLVLICAMFAICWVAYIQWESTIasFTQSINISMAQY 242
Cdd:COG2814   169 VNAVLALLALLLLLRLLP-ESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLY--LQEVLGLSASAA 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 243 SVLWTINGIMILVAQPLIKPIlyLLKGDLKKQMFVGIVIFMLSFFVTSFAENFTIFVVGMIILTFGEMFVWPAVPTIANQ 322
Cdd:COG2814   246 GLLLALFGLGGVLGALLAGRL--ADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAE 323

                         330       340
                  ....*....|....*....|.
gi 1539804673 323 LAPEGKQGQYQGFVNSAATVG 343
Cdd:COG2814   324 LAPPEARGRASGLYNSAFFLG 344
MFS_1 pfam07690
Major Facilitator Superfamily;
10-348 3.01e-24

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 102.11  E-value: 3.01e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  10 LVIGMALNITGSSFLWPLNTIYMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCSTTLLN 89
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  90 FFHGWPWYAVWLVMLGFGGGMIIPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVAVGAAMGGFVAE-FSFNYIFLANLIM 167
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVsAGFGLGAALGPLLGGLLASlFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 168 YIVFALVAI---TQFNIEIKAKVKYPTHLDITGKKNKARFISLVLICAMFAIcWVAYIQWESTIASFTQSINISMAQYSV 244
Cdd:pfam07690 161 SLLAAVLLLlprPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLF-GFAFFGLLTYLPLYQEVLGLSALLAGL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 245 LWTINGIMILVAQPLIKPIL-YLLKGDLKKQMFVGIVIFMLSFFVTSFAENFTIFVVGMIILTFGEMFVWPAVPTIANQL 323
Cdd:pfam07690 240 LLGLGGLLGAIGRLLLGRLSdRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDL 319

                         330       340
                  ....*....|....*....|....*
gi 1539804673 324 APEGKQGQYQGFVNSAATVGKAFGP 348
Cdd:pfam07690 320 APKEERGTASGLYNTAGSLGGALGP 344
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 225-390 1.09e-05

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 47.37  E-value: 1.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 225 ESTIASFTQSI---NISMAQYSVLWTINGIMilVAQPLIKPILYLL--KGDLKKQMFVGIVIFMLSFFVTSFAENFTIFV 299
Cdd:TIGR00711  17 DSTIVNVAIPTiagDLGSSLSQVQWVITSYM--LANAISIPLTGWLakRFGTRRLFLISTFAFTLGSLLCGVAPNLELMI 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 300 VGMIILTFGEMFVWPAVPTIANQLAPEGKQGQYQGFVNSAATVGKAFGPFLGGVLVDAFNMRMMFIGMMVLLVFALIL-L 378
Cdd:TIGR00711  95 IFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVVaF 174

                         170
                  ....*....|..
gi 1539804673 379 MIFKESNEQTKK 390
Cdd:TIGR00711 175 FILPRDKPAASE 186
PRK10091 PRK10091
MFS transport protein AraJ; Provisional
 9-175 7.96e-05

MFS transport protein AraJ; Provisional


Pssm-ID: 182234 [Multi-domain]  Cd Length: 382  Bit Score: 44.31  E-value: 7.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673   9 WLVIGMALNITGSSFLW-PLNTIYMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCSTTL 87
Cdd:PRK10091  202 WLIFAATMFGNAGVFAWfSYIKPYMMFISGFSETSMTFIMMLVGLGMVLGNLLSGRLSGRYSPLRIAAVTDFIIVLALLM 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  88 LNFFHGWPWYAVWLVMLGFGGGMIIPAIYAMAGAVWPNGGRQTFNA-IYLAQNIGVAVGAAMGGFVAEFSFNYIFLANLI 166
Cdd:PRK10091  282 LFFFGGMKTASLIFAFICCAGLFALSAPLQILLLQNAKGGELLGAAgGQIAFNLGSAIGAYCGGMMLTLGLAYNYVALPA 361


                  ....*....
gi 1539804673 167 MYIVFALVA 175
Cdd:PRK10091  362 ALLSFAAMS 370
 
Name Accession Description Interval E-value
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 7-381 9.86e-94

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 285.66  E-value: 9.86e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673   7 VWWLVIGMALNITGSSFLWPLNTIYMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCSTT 86
Cdd:cd17329     1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  87 LLNFFHGWPWYAVWLVMLGFGGGMIIPAIYAMAGAVWPNGGRQ-TFNAIYLAQNIGVAVGAAMGGFVAEFSFNYIFLANL 165
Cdd:cd17329    81 LLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTrAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 166 IMYIVFALVAITQFNIEIKAKVKYPTHLDITGKKNKARFISLVLICAMFAICWVAYIQWESTIASF-TQSINISMAQYSV 244
Cdd:cd17329   161 VLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYvVEILGLGESLLGL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 245 LWTINGIMILVAQPLIKPilYLLKGDLKKQMFVGIVIFMLSFFVTSFAENFTIFVVGMIILTFGEMFVWPAVPTIANQLA 324
Cdd:cd17329   241 LLALNALLIVLLQFPVAR--LVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALA 318

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1539804673 325 PEGKQGQYQGFVNSAATVGKAFGPFLGGVLVDAFNMRMMFIGMMVLLVFALILLMIF 381
Cdd:cd17329   319 PPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGL 375
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 10-382 8.17e-34

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 129.23  E-value: 8.17e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  10 LVIGMALNITGSSFLWPLNTIYMkQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCSTTLLN 89
Cdd:cd17325     1 LSLALFLDMLGYGIIIPILPLYA-ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  90 FFHGWPWYAVWLVMLGFGGGMIIPAIYAMAGAVWPNGGRQTFNAIYL-AQNIGVAVGAAMGGFVAE-FSFNYIFLANLIM 167
Cdd:cd17325    80 FATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSsAIGLGFLIGPLLGGLLADaLGYRAPFLVCAAL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 168 YIVFALVAIT--QFNIEIKAKVKYPTHLDITGKKNKARFISLVLICAMFAICWVAYIQWESTIASFTQS-INISMAQYSV 244
Cdd:cd17325   160 ALLALVLALLllPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAElGGLSPAQIGL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 245 LWTINGIMILVAQPLIKPILYllKGDLKKQMFVGIVIFMLSFFVTSFAENFTIFVVGMIILTFGEMFVWPAVPTIANQLA 324
Cdd:cd17325   240 LFGAQGLASALSQPPAGKLSD--RIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIV 317

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1539804673 325 PEGKQGQYQGFVNSAATVGKAFGPFLGGVLVDAFNMRMMFIGMMVLLVFALILLMIFK 382
Cdd:cd17325   318 PPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
5-343 2.38e-27

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 110.83  E-value: 2.38e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673   5 KSVWWLVIGMALNITGSSFLWPLNTiYMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCS 84
Cdd:COG2814    10 LALLALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  85 TTLLNFFHGWPWYAVWLVMLGFGGGMIIPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVAVGAAMGGFVAE-FSFNYIFL 162
Cdd:COG2814    89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLgAGLGLGPALGPLLGGLLADlFGWRWVFL 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 163 ANLIMYIVFALVAITQFNiEIKAKVKYPTHLDITGKKNKARFISLVLICAMFAICWVAYIQWESTIasFTQSINISMAQY 242
Cdd:COG2814   169 VNAVLALLALLLLLRLLP-ESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLY--LQEVLGLSASAA 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 243 SVLWTINGIMILVAQPLIKPIlyLLKGDLKKQMFVGIVIFMLSFFVTSFAENFTIFVVGMIILTFGEMFVWPAVPTIANQ 322
Cdd:COG2814   246 GLLLALFGLGGVLGALLAGRL--ADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAE 323

                         330       340
                  ....*....|....*....|.
gi 1539804673 323 LAPEGKQGQYQGFVNSAATVG 343
Cdd:COG2814   324 LAPPEARGRASGLYNSAFFLG 344
MFS_1 pfam07690
Major Facilitator Superfamily;
10-348 3.01e-24

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 102.11  E-value: 3.01e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  10 LVIGMALNITGSSFLWPLNTIYMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCSTTLLN 89
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  90 FFHGWPWYAVWLVMLGFGGGMIIPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVAVGAAMGGFVAE-FSFNYIFLANLIM 167
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVsAGFGLGAALGPLLGGLLASlFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 168 YIVFALVAI---TQFNIEIKAKVKYPTHLDITGKKNKARFISLVLICAMFAIcWVAYIQWESTIASFTQSINISMAQYSV 244
Cdd:pfam07690 161 SLLAAVLLLlprPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLF-GFAFFGLLTYLPLYQEVLGLSALLAGL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 245 LWTINGIMILVAQPLIKPIL-YLLKGDLKKQMFVGIVIFMLSFFVTSFAENFTIFVVGMIILTFGEMFVWPAVPTIANQL 323
Cdd:pfam07690 240 LLGLGGLLGAIGRLLLGRLSdRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDL 319

                         330       340
                  ....*....|....*....|....*
gi 1539804673 324 APEGKQGQYQGFVNSAATVGKAFGP 348
Cdd:pfam07690 320 APKEERGTASGLYNTAGSLGGALGP 344
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
10-382 7.32e-23

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 98.77  E-value: 7.32e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  10 LVIGMALNITGSsfLWPlntiYMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCSTTLLN 89
Cdd:COG0738    18 FLWGFATALWGP--LIP----ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFA 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  90 FFHGWPWYAVWLVMLGFGGGMIIPAIYAMAGAVWPNGGRQTFNAIYLAQNIGVAVGAAMGGFVAEFSFN----YIFLANL 165
Cdd:COG0738    92 LAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSlswhLPYLILA 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 166 IMYIVFALVAITQFNIEIKAKVKYPTHLDITGKK--NKARFISLVLICAMFAICWVAYIQWESTIASFTQSINISMAQYS 243
Cdd:COG0738   172 VLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSllKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALG 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 244 VLWTINGIMI--LVAQPLIKPIlyllkgDLKKQMFVGIVIFMLSFFVTSFAENFTIFVVGMIILTFGEMFVWPAVPTIAN 321
Cdd:COG0738   252 LSLFWGGMTIgrFLGGFLLKRF------GPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLAL 325

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1539804673 322 QLAPEgKQGQYQGFVNSAATVGKAFGPFLGGVLVDAFNMRMMFIGMMVLLVFALILLMIFK 382
Cdd:COG0738   326 DGLGK-RTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALK 385
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
1-382 7.88e-22

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 95.71  E-value: 7.88e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673   1 MNIPKSVWWLVIGMALNITGSSFL----WPLNTIYMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILI 76
Cdd:COG2271     1 ARAPSRYRWRILALLFLAYFLNYLdrsnLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  77 GTLTCLCSTTLLNFFHGWPWYAVWLVMLGFGGGMIIPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVAVGAAMGGFVAE- 154
Cdd:COG2271    81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFnAGGPLGGALAPPLLGWLLAa 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 155 FSFNYIFLANLIMYIVFALVaitqfnieikakvkypthlditgkknkaRFISLVLICAMFAICWVAYIQWESTIasFTQS 234
Cdd:COG2271   161 FGWRAAFLILGLPGLLLALL----------------------------RFWLLALAYFLVYFALYGFLTWLPTY--LVEV 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 235 INISMAQYSVLWTINGIMILVAQPLIKPILYLLKGDLKKQMFVGIVIFMLSFFVTSFAENFTIFVVGMIILTFGEMFVWP 314
Cdd:COG2271   211 RGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFG 290

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1539804673 315 AVPTIANQLAPEGKQGQYQGFVNSAATVGKAFGPFLGGVLVDAFNMRMMFIGMMVLLVFALILLMIFK 382
Cdd:COG2271   291 LLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLL 358
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 32-381 7.28e-21

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 93.02  E-value: 7.28e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  32 MKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCSTTLLNFFHGWPWYAVWLVMLGFGGGMI 111
Cdd:cd17474    25 IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGL 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 112 IPAIYAMAGAVWPNGGRQTFNAIYLAQN-IGVAVGAAMGGFVAEFSFNYIFLANLIMyIVFALVAITQFNIEIKAKVK-- 188
Cdd:cd17474   105 GPLALTLIGDLFEGGERAKAMGLYEAALgLGIAVGPLLGGLLAAISWRYPFFLLAAL-IPVAFLAILFLLPEPKEKAKss 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 189 -YPTHLDITGKKNKARFISLVLICAMFAICWVAYIQWESTIASftQSINISMAQYSVLWTINGIMILVAQPLIKPILyLL 267
Cdd:cd17474   184 sATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLE--LLYGISPIIIGLLFAGWSVLLALGSLFVGRLL-KK 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 268 KGDLKKQMFVGIVIFMLSFFVTSFAENFTIFVVGMIILTFGEMFVWPAVPTIANQLAPEGKQGQYQGFVNSAATVGKAFG 347
Cdd:cd17474   261 RFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVG 340

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1539804673 348 PFLGGVLVDAFNMRMMFIGMMVLLVFALILLMIF 381
Cdd:cd17474   341 PLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 34-379 8.70e-21

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 92.66  E-value: 8.70e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  34 QELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCSTTLLNFFHGWPWYAVWLVMLGFGGGMIIP 113
Cdd:cd17489    24 HDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTT 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 114 AIYAMAGAVWPNGGRQTFNAIY-LAQNIGVAVGAAMGGFVAE-FSFNYIF-LANLIMYIVFALVAITQFNIEIKAKVKYP 190
Cdd:cd17489   104 AAATLVADIIPPSRRGEGIGYYgLATTLAMALGPALGLFLYQhLGFAVLFiVAAVLALLALLLVFLVKDPPPVAAEEAEA 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 191 THLDITGKKNK-ARFISLVLICAMFAICWVAyiqweSTIASFTQSINISMAqySVLWTINGIMILVAQPLIKpiLYLLKG 269
Cdd:cd17489   184 GTRAFRRLVEKkVLPPALILFLASIAYGAIS-----TFLPLYAAERGISNA--GLFFTVYAIALLLSRPFSG--KLSDRK 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 270 DLKKQMFVGIVIFMLSFFVTSFAENFTIFVVGMIILTFGEMFVWPAVPTIANQLAPEGKQGQYQGFVNSAATVGKAFGPF 349
Cdd:cd17489   255 GPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGL 334

                         330       340       350
                  ....*....|....*....|....*....|
gi 1539804673 350 LGGVLVDAFNMRMMFIGMMVLLVFALILLM 379
Cdd:cd17489   335 LLGLVAELFGYRAMFLLAAVVVLLALVLYI 364
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 36-380 2.39e-19

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 88.40  E-value: 2.39e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  36 LGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCSTTLLNFFHGWPWYAVWLVMLGFGGGMIIPAI 115
Cdd:cd17330    29 LGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVAQ 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 116 YAMAGAVWPNGGRQTFNAIYLAQNIGVAVGAAMGGFVAefSFNYIFLANLIMYIVFALVAITQFnieikakvkypthldi 195
Cdd:cd17330   109 AYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLS--TPYGYALPFLVAAALALLNLVLVL---------------- 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 196 tgkknkaRFIS-LVLICAMFAICWVAYIQWESTIASFT-QSINISMAQYSVLWTINGIMILVAQPLIKPILYLLKGDlKK 273
Cdd:cd17330   171 -------FFLPpLRRLLLVYFLIALAFAGLESVFSLFLkDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGE-RK 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 274 QMFVGIVIFMLSFFVTSFAENFTIFVVGMIILTFGEMFVWPAVPTIANQLAPEGKQGQYQGFVNSAATVGKAFGPFLGGV 353
Cdd:cd17330   243 LLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGP 322

                         330       340
                  ....*....|....*....|....*..
gi 1539804673 354 LVDAFNMRMMFIGMMVLLVFALILLMI 380
Cdd:cd17330   323 LYSFLGPGVPFLLAAGLLLIALFLLSL 349
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 30-378 9.05e-17

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 80.93  E-value: 9.05e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  30 IYMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCSTTLLNFFHGWPWYAVWLVMLGFGGG 109
Cdd:cd06174    20 PALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSG 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 110 MIIPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVAVGAAMGGFVAE---FSFNYIFLANLIMYIVFALVAITQF----NI 181
Cdd:cd06174   100 LIDPAVLALIADLFPERERGRALGLLqAFGSVGGILGPLLGGILASslgFGWRAVFLIAAALALLAAILLLLVVpdppES 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 182 EIKAKVKYPTHLDITGKKNKARFISLVLICAMFAICWVAYIQWESTIASF-TQSINISMAQYSVLWTINGIMILVAQPLI 260
Cdd:cd06174   180 ARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFlLDLGGLSVAVAGLLLSLFGLAGALGSLLL 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 261 kPILYLLKGDLKKQMFVGIVIFMLSFFVTSFAENFTIFVVGMIILTFGEMFVWPAVPTIANQLAPEGKQGQYQGFVNSAA 340
Cdd:cd06174   260 -GLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFG 338

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1539804673 341 TVGKAFGPFLGGVL-VDAFNMRMMFIGMMVLLVFALILL 378
Cdd:cd06174   339 FLGGAIGPLLAGFLlAATFGLTGAFLVLAVLLLLAAILL 377
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 8-381 2.85e-16

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 79.58  E-value: 2.85e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673   8 WWLVIGMALNITGSSFLWPLNTIYMKQeLGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCSTTL 87
Cdd:cd06173     2 RLLWLAQLLSALGDWIFTVALPWLVLQ-LTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  88 LNFFHGWPWYAVWLVML-----GFGGGMIIPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVAVGAAMGGF-VAEFSFNYI 160
Cdd:cd06173    81 LALLALLGSLSLWLLLVlafllGIASAFFGPARQALLPELVPKEQLVRANALNsLATQLARIIGPALGGLlVALLGPGGA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 161 FLANLIMYIVFALVA----ITQFNIEIKAKVKYPTHLDITGKKNKARFISLVLICAMFAICWVAYIQWESTIASFTQSIN 236
Cdd:cd06173   161 FAINALSFLLSALLLlfirRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 237 ISMAQYSVLWTINGIMILVAQPLIKPILYLLKgdLKKQMFVGIVIFMLSFFVTSFAENFTIFVVGMIILTFGEMFVWPAV 316
Cdd:cd06173   241 GGAAGYGLLLAAFGVGALLGALLLGRLSKRRR--RGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPL 318

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1539804673 317 PTIANQLAPEGKQGQYQGFVNSAATVGKAFGPFLGGVLVDAFNMRMMFIGMMVLLVFALILLMIF 381
Cdd:cd06173   319 NTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
7-389 1.93e-15

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 77.23  E-value: 1.93e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673   7 VWWLVIGMALNItGSSFLWPLNTIYMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCSTT 86
Cdd:COG2223     7 LLLATLAFFLAF-GVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  87 LLNFFHGWPWYAVWLVMLGFGGGMIIPAIYAMAGAVWPNGGRQTFNAIYLA-QNIGVAVGAAMGGFVAE-FSFNYIFLAN 164
Cdd:COG2223    86 LLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGgGNLGAAVAAFLAPLLIAaFGWRNAFLIL 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 165 LIMYIVFALVAI-----TQFNIEIKAKVKYPTHLDITGKKnkaRFISLVLICAMFAICWVAYIQWESTIasFTQSINISM 239
Cdd:COG2223   166 GILLLVVAVLAWlflrdPPAGAAAAAKASLRDQLEALRDP---RFWLLSLLYFGTFGSFIGFSSWLPPY--LVDQFGLSA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 240 AQYSVLWTINGIMILVAQPLIKPILYLLKGdlKKQMFVGIVIFMLSFFVTSFA-ENFTIFVVGMIILTFGEMFVWPAVPT 318
Cdd:COG2223   241 ATAGLLAALFALLGALGRPLGGWLSDRIGG--RRVLLIVFALMALGLLLLALAlGSLWLFLVLFLLLGLALGGGNGAVFA 318

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1539804673 319 IANQLAPEGKQGQYQGFVNSAATVGKAFGPFLGGVLVDAF-NMRMMFIGMMVLLVFALILLMIFKESNEQTK 389
Cdd:COG2223   319 LVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATgSYTAAFLVFAVLALVALVLTLLLYRRPRRAA 390
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 4-176 4.21e-14

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 72.99  E-value: 4.21e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673   4 PKSVWWLVIGMALNITGSSFLWPLNTIYMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLC 83
Cdd:cd17325   198 DRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAV 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  84 STTLLNFFHGWPWYAVWLVMLGFGGGMIIPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVAVGAAMGGFVAE-FSFNYIF 161
Cdd:cd17325   278 ALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFnTAFSLGMVLGPLLGGFLYDaFGFATPF 357

                         170
                  ....*....|....*
gi 1539804673 162 LANLIMYIVFALVAI 176
Cdd:cd17325   358 LAAAALLLLAAVLFL 372
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 34-377 1.31e-12

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 68.34  E-value: 1.31e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  34 QELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLgGYKTILIGTLTCLCSTTLLNFF-HGWPWYAVWLVMLGFGGGMII 112
Cdd:cd17324    27 RDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRI-ERRRLLLVLLLLFILGNLLAALaPSFALLLLARALAGLAHGGFW 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 113 PAIYAMAGAVWPNGGRQTFNAIYLAQN-IGVAVGAAMGGFVAE-FSFNYIFLA-NLIMYIVFALVAITQFNIEIKAKVKY 189
Cdd:cd17324   106 AIAAAYAADLVPPEKRGRAIGLVFSGLtLGLVLGRPLGGLLGQlLGWRAAFLAiAVLALLAALLLWRLLPSLPPKKPGSL 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 190 PTHLDITGKKNKARFISLVLICAMFAICWVAYIqweSTIASFTQSINISMAQYSVLWT-INGIMILVAQPLIKpilYLLK 268
Cdd:cd17324   186 GLLSSLLLLLRNPRLRLAYLITFLLFGGFFALY---TYLAPFLTDVPGFSSSAIIGLLlLFGVAGVVGSPLAG---RLAD 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 269 GDLKKQMFVGIVIFMLSFFV-TSFAENFTIFVVGMIILTFGEMFVWPAVPTIANQLAPEGKqGQYQGFVNSAATVGKAFG 347
Cdd:cd17324   260 RGGRRALLIALLLLAAALLLlTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEAR-GLASSLYLAAYNLGGALG 338

                         330       340       350
                  ....*....|....*....|....*....|
gi 1539804673 348 PFLGGVLVDAFNMRMMFIGMMVLLVFALIL 377
Cdd:cd17324   339 AALGGLVLDHGGWAGVGWVGAALLLLALLL 368
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
5-144 3.00e-12

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 67.31  E-value: 3.00e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673   5 KSVWWLVIGMALNITGSSFLWPLNTIYMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCS 84
Cdd:COG2814   207 PRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALG 286

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1539804673  85 TTLLNFFHGWPWYAVWLVMLGFGGGMIIPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVAV 144
Cdd:COG2814   287 LLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYnSAFFLGGPL 347
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
201-381 3.00e-12

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 67.31  E-value: 3.00e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 201 KARFISLVLICAMFAICWVAYIQWESTIASFTQSINISMAQYSVLWTINGIMILVAQPLIKPILYLLkgDLKKQMFVGIV 280
Cdd:COG2814     6 RRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRF--GRRRVLLLGLL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 281 IFMLSFFVTSFAENFTIFVVGMIILTFGEMFVWPAVPTIANQLAPEGKQGQYQGFVNSAATVGKAFGPFLGGVLVDAFNM 360
Cdd:COG2814    84 LFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGW 163

                         170       180
                  ....*....|....*....|.
gi 1539804673 361 RMMFIGMMVLLVFALILLMIF 381
Cdd:COG2814   164 RWVFLVNAVLALLALLLLLRL 184
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 228-383 1.52e-11

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 65.29  E-value: 1.52e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 228 IASFTQSINISMAQYSVLWTINGIMILVAQPLIKpiLYLLKGDLKKQMFVGIVIFMLSFFVTSFAENFTIFVVGMIILTF 307
Cdd:cd17325    19 LPLYAESLGASVAQIGLIVAAYALAQLLFSPPAG--RLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGL 96

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1539804673 308 GEMFVWPAVPTIANQLAPEGKQGQYQGFVNSAATVGKAFGPFLGGVLVDAFNMRMMFIGMMVLLVFALILLMIFKE 383
Cdd:cd17325    97 ASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLP 172
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 23-378 1.53e-11

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 65.04  E-value: 1.53e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  23 FLWPLNTIYMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCSTTLLNFFHGWPWYAVWLV 102
Cdd:cd17333    13 ALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMF 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 103 MLGFGGGMIIPAIYAMAGAVWPNGGRQTFNAIYLAQNIGVAVGAAMGGFV--AEFSFNYIFL-ANLIMYIVFALVAITQF 179
Cdd:cd17333    93 LAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLltSELSWSWAYLiIGLIYLLLAILILLTLF 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 180 -NIEIKAKVKYPTHLDITGKKNKARFISLVLIcAMFAICWV----AYIQWESTIASFTQSINISMAQYSVLWTINGIMI- 253
Cdd:cd17333   173 pELPSARNPQQSVGAFSASASRLLRNPSIILG-ALALFLYVgaetAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIg 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 254 -LVAQPLIKPILYllkgdlKKQMFVGIVIFMLSFFVTSFAENFTIFVVGMIILTFGEMFVWPAVPTIANQLAPeGKQGQY 332
Cdd:cd17333   252 rLLGGPISRRIKP------HTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLP-YAKGKG 324

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1539804673 333 QGFVNSAATVGKAFGPFLGGVLVDAFNMR--MMFIGMMVLLVFALILL 378
Cdd:cd17333   325 TSVLLAAGSIGGAIIPFIMGFIAEAVGIQtaMLLITILYAIIFVLALL 372
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
8-393 2.79e-11

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 64.54  E-value: 2.79e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673   8 WWLVIGMALNITGSSFLWPLNT----IYMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFD----KLGGYKT-ILIGT 78
Cdd:COG2211     9 LKEKLAYGLGDLGLNLAFGLLSayllYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDrtrtRWGRRRPwILIGA 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  79 LTCLCSTTLLNFFHGWP------WYAVWLVMLGFGGGMIIPAIYAMAGAVWPNGGRQT--FNAIYLAQNIGVAVGAAMGG 150
Cdd:COG2211    89 IPLALSFVLLFTAPDLSptgkliYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTrlSSWRFAFAGLGGLLASVLPP 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 151 FVAEFSFNYIFLANLIMYIVFALVA-----ITQFNIEIKAKVKYPTHLDITGKKNKARFISLVLICAMFAICWVAYIQWE 225
Cdd:COG2211   169 PLVAAFGGDAALGYRLTALIFAVLGllaflLTFFGTKERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVA 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 226 STIASF-TQSINISMAQYSVLWTINGIMILVAQPLIKPILYLLkgDLKKQMFVGIVIFMLSFFVTSFA--ENFTIFVVGM 302
Cdd:COG2211   249 ALLLYYfKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRF--GKKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLA 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 303 IILTFGEMFVWPAVPTIANQLAPEGKQ-------GQYQGFVNSAATVGKAFGPFLGGVLVDAFNMR-------------- 361
Cdd:COG2211   327 ALAGIGLGAILVLPWAMLADVVDYDEWktgrrreGLYFGIFTFAIKLGQALAGALAGLLLALFGYVagaaqspsaltgir 406

                         410       420       430
                  ....*....|....*....|....*....|...
gi 1539804673 362 -MMFIGMMVLLVFALILLMIFKESNEQTKKIDA 393
Cdd:COG2211   407 lLFFLLPAVLLLLAALLLLFYPLTRERHAEIRA 439
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 10-378 7.20e-11

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 62.98  E-value: 7.20e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  10 LVIGMALNITGSSFLWPLNTIYMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCSTTLLN 89
Cdd:cd17473     4 LLLASTLTVMAGAAIAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  90 FFHGWPWYAVWLVMLGFGGGMIIPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVAVGAAMGGFVAEFSFNYIFLANLIMY 168
Cdd:cd17473    84 FLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQsAAMSLGGVVFLLLGGALAEIGWRAPFLVYLLAL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 169 IVFALVAITQFNIEIKAKVKYPTHLDITGKKNKAR-FISLVLICAMFAICWVAYIQwestIASFTQSINI-SMAQYSVLW 246
Cdd:cd17473   164 PVLILVLLFLPEPARKSKSAASPGAATAAALPWKRvLPIYFLAFLAMLLFYVIPIQ----LPFLLQERGGgSAALIGLAL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 247 TINGIMILVAQPLIKPILYLLKGdlKKQMFVGIVIFMLSFFVTSFAENFTIFVVGMIILTFGEMFVWPAVPTIANQLAPE 326
Cdd:cd17473   240 AIASLAGAIGALLFGRLKRRLGK--RRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPP 317

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1539804673 327 GKQGQYQGFVNSAATVGKAFGPFLGGVLVDAFN--MRMMFIGMMVLLVFALILL 378
Cdd:cd17473   318 ELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGglSGAFLILGVLALVLAIVLL 371
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 20-378 3.06e-10

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 61.06  E-value: 3.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  20 GSSFLWPLNTIYMKQeLGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCSTTLLNFF--HGWPWY 97
Cdd:cd17335    12 ALGSLLPFLSVYLKQ-LGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSLFFvaQIFWLL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  98 AVWLVMLGFGGGMIIPAIYAMAGAvWPNGGRQTFNAIYLAQNIGVAVGA-AMGGFVAEFSFNYIFLANLIMYIVFALVAI 176
Cdd:cd17335    91 LLLVILGAFFSAPVVPLVDSITLQ-YLGEERERYGKQRLWGSIGFGIAAlLVGILIDRSSTYKNYTIAFYVFAVLMLLAL 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 177 ---TQFNIEIKAKVKYPTHLDITGKKNKARFISLVLICAMFAICWVAYiqwESTIASFTQSINISMAQYSVLWTINGIMI 253
Cdd:cd17335   170 llaLKFPFRPKHPEPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLI---YSFLFWHLQDLGGSKTLIGLLWTVGVVSE 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 254 LVAQPLIKPILYLLKgdLKKQMFVGIVIFMLSFFVTSFAEN--FTIFVVGMIILTFGEMfvWPAVPTIANQLAPEGKQGQ 331
Cdd:cd17335   247 IPFFFFSSRLIQRFG--HVGLLYLGLLAYVVRWLLYSFLENpwLVLPIELLHGLTFALV--WAAAVSYASAAAPPGLRAT 322

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1539804673 332 YQGFVNSA-ATVGKAFGPFLGGVLVDAFNMRMMF--IGMMVLLVFALILL 378
Cdd:cd17335   323 AQGLLQGLyFGLGGGLGSLIGGYLYEAFGARTTFrfFAIAALAGLLAFFL 372
MFS_1 pfam07690
Major Facilitator Superfamily;
209-383 8.32e-10

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 59.74  E-value: 8.32e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 209 LICAMFAICWVAYIQWESTIASFTQSINISMAQYSVLWTINGIMILVAQPLIKPILYLLkgDLKKQMFVGIVIFMLSFFV 288
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRF--GRRRVLLIGLLLFALGLLL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 289 TSFAENFTIFVVGMIILTFGEMFVWPAVPTIANQLAPEGKQGQYQGFVNSAATVGKAFGPFLGGVLVDAFNMRMMFIGMM 368
Cdd:pfam07690  79 LLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILA 158

                         170
                  ....*....|....*
gi 1539804673 369 VLLVFALILLMIFKE 383
Cdd:pfam07690 159 ILSLLAAVLLLLPRP 173
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 10-180 1.81e-09

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 58.74  E-value: 1.81e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  10 LVIGMALNitGSSFLWPLntiYMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCSTTLLN 89
Cdd:cd17503   188 FLLGLGLF--GAMFLLPL---YLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLA 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  90 FFH---GWPWYAVWLVMLGFGGGMIIPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVAVGAAMGGFVAEF--SFNYIFLA 163
Cdd:cd17503   263 FLTpdtSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFnTIRQLGGSIGTALLATLLTNrtQFHHSRLS 342

                         170
                  ....*....|....*..
gi 1539804673 164 NLIMYIVFALVAITQFN 180
Cdd:cd17503   343 ELLAQQVQKQALIIAFN 359
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 194-384 2.37e-09

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 57.90  E-value: 2.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 194 DITGKKNKARFISLVLICAMFAICWVAYIQWESTIASFTQSINISMAQYSVLWTINGIMILVAQPLIKPIlyllkGDL-- 271
Cdd:COG0477     3 STDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRL-----GDRyg 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 272 -KKQMFVGIVIFMLSFFVTSFAENFTIFVVGMIILTFGEMFVWPAVPTIANQLAPEGKQGQYQGFVNSAATVGKAFGPFL 350
Cdd:COG0477    78 rKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLL 157

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1539804673 351 GGVLVDAFNMRMMFIGMMVLLVFALILLMIFKES 384
Cdd:COG0477   158 GGLLVAALGWRWIFLINAPLGLLALVLRLRLPES 191
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
5-176 2.52e-09

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 58.35  E-value: 2.52e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673   5 KSVWWLVIGMALNITGSSFLWPLNTIYMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCS 84
Cdd:COG2223   205 PRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALG 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  85 TTLLNFFHGWPWYAVWLVM-LGFGGGMIIPAIYAMAGAVWPnggrqtfnAIYLAQNIG-VAVGAAMGGFVAEFSFNYIFL 162
Cdd:COG2223   285 LLLLALALGSLWLFLVLFLlLGLALGGGNGAVFALVPDIFP--------TKNAGAVYGlVGAAGGLGGFLGPLLFGALLD 356

                         170
                  ....*....|....*...
gi 1539804673 163 A----NLIMYIVFALVAI 176
Cdd:COG2223   357 AtgsyTAAFLVFAVLALV 374
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
4-156 4.12e-09

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 57.99  E-value: 4.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673   4 PKSVWWLVIGMALNITGSSFLWPLNTIYMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLC 83
Cdd:COG2211   227 NRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAAL 306

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  84 STTLLNFF--HGWPWYAVWLVMLGFGGGMIIPAIYAMAGAV-----WPNGGRQT---FNAIYLAQNIGVAVGAAMGGFVA 153
Cdd:COG2211   307 GLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVvdydeWKTGRRREglyFGIFTFAIKLGQALAGALAGLLL 386


                  ...
gi 1539804673 154 EFS 156
Cdd:COG2211   387 ALF 389
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 26-379 9.00e-09

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 56.78  E-value: 9.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  26 PLNTIYMKqELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCSTTLLNFFHGWPWYAVWLVMLG 105
Cdd:cd17370    20 SILPLFLV-VLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLVILGYGLSALAKPLLALAGSWQLVLLLRILE 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 106 -FGGGMIIPAIYAM-AGAVWPNGGRQTFNAIYLAQNIGVAVGAAMGGFV---AEFSFNYIFLANLIMYIvFALVAITQFN 180
Cdd:cd17370    99 rLGKGIRTPPRDALlADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLlylLGGNYRTIFLLAAIPAL-LALLILLFVV 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 181 IEIKAKVKYPTHLDITGKKN-KARFISLVLICAMFAICWVAYiqweSTIASFTQSINISMAQYSVLWTI-NGIMILVAQP 258
Cdd:cd17370   178 KEYPRPPKLRKKSKKTSLKKlPKAFWLYLLAVALFALGNFSF----AFLILRAQELGLSAALIPLLYALfNLVYALAAYP 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 259 LikPILYLLKGdLKKQMFVGIVIFMLSFFVTSFAENFTIFVVGMIILTFGEMFVWPAVPTIANQLAPEGKQGQYQGFVNS 338
Cdd:cd17370   254 A--GRLSDRIG-RKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNT 330

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1539804673 339 AATVGKAFGPFLGGVLVDAFNMRMMFIGMMVLLVFALILLM 379
Cdd:cd17370   331 VVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 271-378 9.72e-09

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 56.43  E-value: 9.72e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 271 LKKQMFVGIVIFMLSFFVTSFAENFTIFVVGMIILTFGEMFVWPAVPTIANQLAPEGKQGQYQGFVNSAATVGKAFGPFL 350
Cdd:cd17503    60 TRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTL 139

                          90       100
                  ....*....|....*....|....*...
gi 1539804673 351 GGVLVDAFNMRMMFIGMMVLLVFALILL 378
Cdd:cd17503   140 GGWLTDNLSWRWIFYINLPIGILALLLA 167
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
32-381 1.29e-08

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 56.42  E-value: 1.29e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  32 MKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCSTTLLNFFHGWPWYAVWLVMLGFGGGMI 111
Cdd:COG2807    44 IRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVG 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 112 IPAIYAMAGAVWPNgGRQTFNAIY-LAQNIGVAVGAAMGGFVAE-FSFNYIFLANLIMYIVFALVAITQFNIEIKAKVKY 189
Cdd:COG2807   124 NVLLPGLIKRWFPD-RVGLMTGLYtAAMGLGAALAAGLTVPLAAaLGWRGALAVWALLALLALLLWLPLLRRRPAAAAAA 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 190 PTHLDITGKKNKARFISLVLICAMFAICWVAYIQWestIASFTQSINISMAQYSVLWTINGIMILVAQPLIkPILYLLKG 269
Cdd:COG2807   203 PAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAW---LPPILRDAGLSAATAGLLLSLFQLAGIPGSLLV-PLLADRLG 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 270 DLKKQMFVGIVIFMLSFFVTSFAENfTIFVVGMIILTFGEMFVWPAVPTIANQLAPEGKQ-GQYQGFVNSAATVGKAFGP 348
Cdd:COG2807   279 DRRPLLLLLGLLGLAGLLGLLLAPG-SLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEaAALSGMAQSVGYLLAALGP 357

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1539804673 349 FLGGVLVDAF-NMRMMFIGMMVLLVFALILLMIF 381
Cdd:COG2807   358 LLVGALHDATgSWTAALLLLAALAVLMLVAGLLA 391
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 31-380 1.55e-08

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 56.04  E-value: 1.55e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  31 YMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCSTTLLNFFHGWPWYAVWLVMLGFGGGM 110
Cdd:cd17319    28 TIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAG 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 111 IIPAIYAMAGAVWPNGGRQTFNAIYL-AQNIGVAVGAAMGGFVAE-FSFNYIFLANLIMYIVFALVAItqfnieikakVK 188
Cdd:cd17319   108 FFPGAIKALAEWFPARERGRATGLFNsGAPLGAAIGPPLSGWLLLlFGWRWAFIIEGLLGLLLAVLWW----------FY 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 189 YPthlditgkknkaRFISLVLICAMFAICWVAYIQWESTIasFTQSINISMAQYSVLWTINGIMILVAQPLIKPIL-YLL 267
Cdd:cd17319   178 LR------------QVWGLALGYFGINYALYGLLTWLPTY--LKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSdRLL 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 268 KGDLKKQMFVGIVIFMLSFFVTSFAENFTIFVVGMIILTFGEMFVWPAVPTIANQLAPEGKQGQYQGFVNSAATVGKAFG 347
Cdd:cd17319   244 RGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVA 323

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1539804673 348 PFLGGVLVDAF-NMRMMFIGMMVLLVFALILLMI 380
Cdd:cd17319   324 PLLIGYLVDATgSYTAAFLFLAAVALLAALLVLL 357
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 5-176 1.80e-08

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 55.63  E-value: 1.80e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673   5 KSVWWLVIGMALNITGSSFLWPLNTIYMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCS 84
Cdd:cd17324   198 PRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAAL 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  85 TTLLNFFHGWPWYAVWLVMLGFGGGMIIPAIYAMAGAVWPnGGRQTFNAIYL-AQNIGVAVGAAMGGFV-AEFSFNYIFL 162
Cdd:cd17324   278 LLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP-EARGLASSLYLaAYNLGGALGAALGGLVlDHGGWAGVGW 356

                         170
                  ....*....|....
gi 1539804673 163 ANLIMYIVFALVAI 176
Cdd:cd17324   357 VGAALLLLALLLAL 370
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 7-178 2.42e-08

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 55.31  E-value: 2.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673   7 VWWLVIGMALNITGSSFLWPLNTIYMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCSTT 86
Cdd:cd06173   210 LRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALL 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  87 LLNFFHGWPWYAVWLVMLGFGGGMIIPAIYAMAGAVWPNGGR-QTFNAIYLAQNIGVAVGAAMGGFVAE-FSFNYIFLAN 164
Cdd:cd06173   290 VLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRgRVFSVYNALNSGAMPLGALLAGLLADaLGLSAVFLLA 369

                         170
                  ....*....|....
gi 1539804673 165 LIMYIVFALVAITQ 178
Cdd:cd06173   370 GALLLLAALLLLLL 383
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 231-381 3.21e-08

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 54.86  E-value: 3.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 231 FTQSINISMAQYSVLWTINGIMILVAQPLIKPILYLLkgDLKKQMFVGIVIFMLSFFVTSFAENFTIFVVGMIILTFGEM 310
Cdd:cd17324    25 IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRI--ERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHG 102

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1539804673 311 FVWPAVPTIANQLAPEGKQGQYQGFVNSAATVGKAFGPFLGGVLVDAFNMRMMFIGMMVLLVFALILLMIF 381
Cdd:cd17324   103 GFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRL 173
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 272-383 6.77e-08

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 53.75  E-value: 6.77e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 272 KKQMFVGIVIFMLSFFVTSFAENFTIFVVGMIILTFGEMFVWPAVPTIANQLAPEGKQGQYQGFVNSAATVGKAFGPFLG 351
Cdd:cd17489    61 KRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALG 140

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1539804673 352 GVLVDAFNMRMMFIGMMVLLVFALILLMIFKE 383
Cdd:cd17489   141 LFLYQHLGFAVLFIVAAVLALLALLLVFLVKD 172
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 32-177 1.24e-07

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 52.89  E-value: 1.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  32 MKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCSTTLLNFFHGWPWYAVWLVMLGFGGGMI 111
Cdd:COG0477    40 IAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGL 119

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1539804673 112 IPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVAVGAAMGGFVAE-FSFNYIFLANLIMYIVFALVAIT 177
Cdd:COG0477   120 MPGALALIAELFPARERGRALGLWgAAIGLGLALGPLLGGLLVAaLGWRWIFLINAPLGLLALVLRLR 187
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 32-358 1.24e-07

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 52.95  E-value: 1.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  32 MKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCSTTLLNFFHGWPWYAVWLVMLGFGGGMI 111
Cdd:cd17321    22 IARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAI 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 112 IPAIYAMAGAVWPNGGRQT-FNAIYLAQNIGVAVGAAMGGFVAE-FSFNYIFLANLIMYIVfALVAITQFNIEIkakvky 189
Cdd:cd17321   102 MPASLALIAATFPGERRGRaLGLWGAVVGIGAALGPLLGGLLLElFGWRWIFLINVPIGLV-ALLLARTFSGAV------ 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 190 pthlditgkknkarfISLVLICAMFAICWVAYIQWESTIASFTQsinismAQYSVLWTINGIMILVAQPLIKPIlyLLKG 269
Cdd:cd17321   175 ---------------LAAFLLGAALGGLLFLLPLYLQGVLGYSP------LQAGLALLPLALAMLVAAPLAGRL--ADRF 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 270 DLKKQMFVGIVIFMLSFFVTSF---AENFTIFVVGMIILTFGEMFVWPAVPTIANQLAPEGKQGQYQGFVNSAATVGKAF 346
Cdd:cd17321   232 GPRLVLVAGLLLTAVGLLLLALlgaDSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGAL 311

                         330
                  ....*....|..
gi 1539804673 347 GPFLGGVLVDAF 358
Cdd:cd17321   312 GVALLGALLTAG 323
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
201-381 1.84e-07

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 52.58  E-value: 1.84e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 201 KARFISLVLICAMFAICWVAYIQWESTIASFTQSINISMAQYSVLWTINGIMILVAQPLIKPILYLLKGdlKKQMFVGIV 280
Cdd:COG2223     1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGP--RRVLLIGLL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 281 IFMLSFFVTSFAENFTIFVVGMIILTFGEMFVWPAVPTIANQLAPEGKQGQYQGFVNSAATVGKAFGPFLGGVLVDAFNM 360
Cdd:COG2223    79 LLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGW 158

                         170       180
                  ....*....|....*....|.
gi 1539804673 361 RMMFIGMMVLLVFALILLMIF 381
Cdd:COG2223   159 RNAFLILGILLLVVAVLAWLF 179
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 10-379 1.91e-07

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 52.55  E-value: 1.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  10 LVIGMALNITGSSFLWPLNTIYMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCL-CSTTLL 88
Cdd:cd17471     1 LLLATLLTGLAGAFVLPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRKPLILLALLAGaLGYLLF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  89 NFFHGWPWYAVWLVMLGFGGGMIIPAIYAMAGAVWPNGGRQ---TFNAIYLAQ-NIGVAVGAAMGGFVA-EFSFNYIFLA 163
Cdd:cd17471    81 AFLRNYWVLLLVGVVLLSLGAAAFPQLFALAREYADRSSGRdatLFNSVLRAAfSLAWVIGPPLAFLLLdVLGFTGLFLL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 164 NLIMYIVFALVAITQFNIEIKAKVKYPTHLDITGKKNKARFISLVLICAMFAICWVAYIqwestiasftqsinISMAQY- 242
Cdd:cd17471   161 AALLYLVVALLVLFLLPSVKPPAQKATPASSLVKAPVNRRLLLLFAAFTLLFAANSMYI--------------IAMPLYv 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 243 ------SVLWTinGIMILVAQPLIKPILYLL-----KGDLKKQMFVGIVIFMLSFFVTSFAENFTIFVVGMIILTFGEMF 311
Cdd:cd17471   227 tnelggSESWV--GLLFGLAAALEIPIMLLAgllakRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGI 304

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1539804673 312 VWPAVPTIANQLAPeGKQGQYQGFVNSAATVGKAFGPFLGGVLVDAFNMRMMFIGMMVLLVFALILLM 379
Cdd:cd17471   305 TAGLGISYFQDLMP-GQPGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 26-376 1.45e-06

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 49.91  E-value: 1.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  26 PLNTIYMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGtLTCLCSTTLLNFFHGWPWyavWLVMLG 105
Cdd:cd17472    17 PVLSVYAKSLPGATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFG-LLLFIAGSLLAAYATSIY---GLILGR 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 106 F--GGGMIIPAIYAMAGAVWPNGGRQTFNAIyLAQNIGVAVGAAMGG---FVAEFSFNYIFLANLIMyivfALVAITQFN 180
Cdd:cd17472    93 AlqGSGAISSVVMALLADLTREENRTKAMAL-IGASIGIAFAISMVLgplLAAHLGVSGLFLITAIL----SLVSLLILL 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 181 IEIKAKVKYPTHLDitgkKNKARFISLVLICAMFAICWVAYIQWESTIASFT---QSINISMAQYSVLWTINGIMILVAQ 257
Cdd:cd17472   168 FFVPDPPKIVQISE----KEKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYilpLLLTQLGGGKGQLWKVYLPAILIGF 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 258 PLIKP-ILYLLKGDLKKQMFVGIVIFMLSFFVT--SFAENFTIFVVGMIILTFGEMFVWPAVPTIANQLAPEGKQGQYQG 334
Cdd:cd17472   244 ILMVPfVIYAEKKGKMKQVFVSSILLIAVGFLLllFAATSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYRGTAMG 323

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 1539804673 335 FVNSAATVGKAFGPFLGGVLVDAFNMRMMFIGMMVLLVFALI 376
Cdd:cd17472   324 IYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILILALLWLL 365
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 8-176 1.68e-06

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 49.52  E-value: 1.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673   8 WWLVIGMALNITGSSFLWPLNTI---YMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCS 84
Cdd:cd17316   177 RRTLLLILLWFFISFGYYGLTTFlptYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGIL 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  85 TTLL--NFFHGWPWYAVWLVMLGFGGGMIIPAIYAMAGAVWPNGGRQTfnAIYLAQNIGVAVGAAMGGFVAEFSFNYIFL 162
Cdd:cd17316   257 ALPLfyLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRAT--GVGLSYNLGRLGGGGAPPLIALLLASTGGT 334

                         170
                  ....*....|....
gi 1539804673 163 ANLIMYIVFALVAI 176
Cdd:cd17316   335 GVPALILALLAIVA 348
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 10-379 1.89e-06

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 49.48  E-value: 1.89e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  10 LVIGMALNITGSSFLWPLNTIyMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCSTTLLN 89
Cdd:cd17478     1 LSLGHFLNDFYQGFLPALLPL-LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  90 FFHGWPWYAVWLVMLGFGGGMIIPAIYAMAGAVwPNGGRQTFNAIY-LAQNIGVAVG-AAMGGFVAEFSFNYIFLANLIM 167
Cdd:cd17478    80 FAPNYWLLLLLVALAGIGSAAFHPEGARLASQA-AGGRRGLAMSIFsVGGNLGFALGpLIAAALVALFGGLGLLILLIIP 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 168 YIVFALVAITQFNIEIKAKVKYPTHLDITGKKNKARFISLVLICAMFAICWVAyiqweSTIASFtqsinismaqYSVLWT 247
Cdd:cd17478   159 GLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVL-----SSLTTF----------LPFYLV 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 248 INGIMILVAQPLIKPILY------LLKGDL------KKQMFVGIVIFMLSFFVTSFAeNFTIFVVGMIILTFGEMFVWPA 315
Cdd:cd17478   224 QRGYSLVFAGLLLSLFLFagaigtLIGGPLsdrfgrRRVIIASLLLAAPFLLLFLLT-PGIWSYILLVLAGFLLFASFPV 302

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1539804673 316 VPTIANQLAPEGK---QGQYQGFVNSAAtvgkAFGPFLGGVLVDAFNMRMMFIGMMVLLVFALILLM 379
Cdd:cd17478   303 TVVLAQELLPGNVglaSGLMMGLSFGLG----GIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 32-381 1.90e-06

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 49.58  E-value: 1.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  32 MKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLtCLCSTTLLNFFHGWPW--YAVWLVMLGFGGG 109
Cdd:cd17355    29 IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLL-LLAAGLVLLALATSLWqlYLLWGLLGGGGAG 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 110 MIIPAIYAMAGAVWPNGGRQT-----FNAIYLAQNIGVAVGAAMGGFVAEFSFNYIFLANLIMYIVFALVAITQFNIEIK 184
Cdd:cd17355   108 TLAAVAFATVAAWWFERRRGLalgilTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPADLA 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 185 AKVKYPTHLDITGKKNKA--RFISLVLICAMFAICWVAYIQWESTIASFTQSINISMAQYSVLWTINGIMILVAQPLIKP 262
Cdd:cd17355   188 LRAYDDASPASPGSTLKEalRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGW 267

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 263 ------------ILYLLKGdlkkqmfVGIVIFMLSFFVTSFAENFTIFVVGMIILTFgemfvwPAVPTIANQLAPEGKQG 330
Cdd:cd17355   268 lgdrysprrllaASYALRA-------LGLALLLLLPFPPLALLLFAALFGLGWGATV------PLTAALAARYFGARSYG 334

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1539804673 331 QYQGFVNSAATVGKAFGPFLGGVLVDAF-NMRMMFIGMMVLLVFALILLMIF 381
Cdd:cd17355   335 TLFGLVFAPHQLGSALGPWLGGLLYDRTgSYTAAWALAVALGLIAALLVLPI 386
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 34-382 2.01e-06

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 49.53  E-value: 2.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  34 QELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKT-ILIGTLTCLCSTTLLNFFHGWPWYAVWLVMLGFGGGMII 112
Cdd:cd17490    24 ESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLfIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAATWV 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 113 PAIYAMAGAVWPNGGRQTFNAIYLAQNIGVAVGAAMGGFVAE-FSFNYIFLanliMYIVFALVA-ITQFNIEIKAKVKYP 190
Cdd:cd17490   104 SFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEhFGMRAPFL----LAALAGVLGfILSLFIKEERREKKP 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 191 THLDI-----TGKKNKARFISLVLICAMFaicwvayIQWeSTIASFT----QSINISMAQYSVLWTINGIMILVAQPLIK 261
Cdd:cd17490   180 VLTELkellsVLKDKKLLFFSLLAILQQM-------ITF-STTFGFTpliaKQLGASSFQLGLLSIIYLLPNALASLLSG 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 262 PILYLLKGdLKKQMFVGIVIFMLSFFVTSFAENFTIFVVGMIILTFGEMFVWPAVPTIANQLAPEGKQGQYQGFVNSAAT 341
Cdd:cd17490   252 TLFYKKLG-ERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYA 330

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1539804673 342 VGKAFGPFLGGVLVDAFNMRMMFIGMMVLLVFALILLMIFK 382
Cdd:cd17490   331 LGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSLAYY 371
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
7-176 2.53e-06

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 49.10  E-value: 2.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673   7 VWWLVIGMALN--ITGSSFLWpLNTIYmkQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCS 84
Cdd:COG2807   217 AWLLTLFFGLQslLYYAVVAW-LPPIL--RDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLA 293

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  85 TTLLNFFHGWPWYAVWLVMLGFGGGMIIPAIYAMAGAVWPNgGRQTFNAIYLAQNIGvAVGAAMGGFVAEF------SFN 158
Cdd:COG2807   294 GLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRART-PAEAAALSGMAQSVG-YLLAALGPLLVGAlhdatgSWT 371

                         170
                  ....*....|....*...
gi 1539804673 159 YIFLANLIMYIVFALVAI 176
Cdd:COG2807   372 AALLLLAALAVLMLVAGL 389
MFS_DtpA_like cd17346
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ...
 29-382 2.97e-06

Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340904 [Multi-domain]  Cd Length: 399  Bit Score: 48.73  E-value: 2.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  29 TIYMKQELGKSLTVAGLVLMINSF-GMV-IGNLLGGSLFDK-LGGYKTILIGTLTCLCSTTLLNFFHGWPWYA-VWLVML 104
Cdd:cd17346    26 ILYLTAQLGDGFSEADAASIYGAYtALVyLTPIIGGWLADKvLGARRTVFIGGILMALGYLLLALSPFSVSMLyLGLALI 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 105 GFGGGMIIPAIYAMAGAVWPNGGRQT---FNAIYLAQNIGVAVGAAMGGFVAE-FSFNYIFLANLIMyIVFALVAITQFN 180
Cdd:cd17346   106 IVGNGLFKPNISSLVGKLYDENDPRRdsgFSIFYMGINLGAFLAPLLCGTLGDnYGYHYGFGLAAVG-MLLGLLIFLLGR 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 181 IEIKakvkypthlditgkkNKARFISLVLICAMFAICWVAYIQWESTIASFTQS--------INISMAQYSVLwtiNGIM 252
Cdd:cd17346   185 KKLL---------------ERKKMLAIIILFLFAVVFWAIYEQAGTSLALFADEnvdrllggFTIPPSWFQSL---NPLF 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 253 ILVAQPLIkPILYLLKGDLKKQ------MFVGIVIFMLSFFVTSFAENFTI---------FVVGMIILTFGEMFVWPAVP 317
Cdd:cd17346   247 IILLAPIL-AALWTKLGKRGKDpsiptkFALGLLLLGLSFLLMVLAASFAGgsgkvsalwLVLSYFLQTLGELCLSPVGL 325

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1539804673 318 TIANQLAPEGKQGQYQGFVNSAATVGKAFGPFLGGV-------LVDAFNMRMMFIGMMVLLVFALILLMIFK 382
Cdd:cd17346   326 SMITKLAPAKFAGFMMGLWFLASALGNILAGYLAGFyaqpkdpLASALVYTDYFGLIGVIALVAGIILLLLA 397
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 210-384 4.07e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 48.58  E-value: 4.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 210 ICAMFAICWVAYIQWESTIASFTQSINISMAQYSVLWTINGIMILVAQPLIKPILylLKGDLKKQMFVGIVIFMLSFFVT 289
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLA--DRFGRRPVLLLGLLLFALGALLF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 290 SFAENFTIFVVGMIILTFGEMFVWPAVPTIANQLAPEGKQGQYQGFVNSAATVGKAFGPFLGGVLVDA--FNMRMMFIGM 367
Cdd:cd06174    79 AFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIA 158

                         170
                  ....*....|....*..
gi 1539804673 368 MVLLVFALILLMIFKES 384
Cdd:cd06174   159 AALALLAAILLLLVVPD 175
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 231-390 4.47e-06

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 48.32  E-value: 4.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 231 FTQSINISMAQYSVLWTINGIMILVAQPLIKpiLYLLKGDLKKQMFVGIVIFMLSFFVTSFAENFTIFVVGMIILTFGEM 310
Cdd:cd17478    22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFG--YLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSA 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 311 FVWPAVPTIANQLAPeGKQGQYQGFVNSAATVGKAFGPFLGGVLVDAFNMRMMFIGMMVLLVFALILLMIFKESNEQTKK 390
Cdd:cd17478   100 AFHPEGARLASQAAG-GRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAK 178
MFS_MosC_like cd17393
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ...
 33-376 5.65e-06

Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340951 [Multi-domain]  Cd Length: 373  Bit Score: 48.02  E-value: 5.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  33 KQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCSTTLLNFFHGWPWYAVWLVMLGFGGGMII 112
Cdd:cd17393    26 KDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAANGALD 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 113 PAIYAMAGAVWPNGGRQTFNAIYLAQNIGVAVGAAMGGFV--AEFSFNYIFLANLIMYIVFALVAITQFnieikAKVKYP 190
Cdd:cd17393   106 VAMNAQGVAVERAYGRPIMSSLHAMWSLGGLAGALLGAAAigAGVSPGVHLLAAAVLLLLAALVAIRAL-----LPGTGE 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 191 THLDITGKKNKARF----ISLVLICAMFAICWVAyiqwESTIAS-----FTQSINISMAQYSVLWTINGIMILVAQplik 261
Cdd:cd17393   181 AAEDRPDGAGKPGFllpnRLLLLLGLLALAAALA----EGAAADwsalyLRDVLGASAALAALGYAVFSLAMTVGR---- 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 262 pilylLKGDLKKQMF-------VGIVIFMLSFFVTSFAENFTIFVVGMIILTFGEMFVWPAVPTIANQLAPeGKQGQYQG 334
Cdd:cd17393   253 -----LFGDRLVDRFgdvavlrAGALLAALGLLLALLAPSVWVALAGFALMGLGLSVVVPLAFSAAGALPG-LAAGIAVA 326

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1539804673 335 FVNSAATVGKAFGPFLGGVLVDAFNMR--MMFIGMMVLLVFALI 376
Cdd:cd17393   327 RVATLGYLGFLVGPPLIGFLADATGLRtaFLVVALLALLVALLA 370
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 32-153 7.46e-06

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 47.58  E-value: 7.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  32 MKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLgGYKTILIGTLTCLCSTTLLNFFHGWPW-YAVWLVMLGFGGGM 110
Cdd:cd17365    25 LAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRF-GRKRVLLVSVALFGLFTLLTAFAQSVLqLALLRFLTGLGLGA 103

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1539804673 111 IIPAIYAMAGAVWPNGGRQTFNAIYLAqniGVAVGAAMGGFVA 153
Cdd:cd17365   104 AMPNAITLVSEYAPARRRSLAVTLMFC---GYPLGAALGGFLA 143
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 3-152 7.63e-06

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 47.55  E-value: 7.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673   3 IPKSVWWLVIGMALNITGSSFLWpLNTIYMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCL 82
Cdd:cd17321   167 ARTFSGAVLAAFLLGAALGGLLF-LLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTA 245

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1539804673  83 CSTTLLNFFH---GWPWYAVWLVMLGFGGGMIIPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVAVGAAMGGFV 152
Cdd:cd17321   246 VGLLLLALLGadsSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILnTARQLGGALGVALLGAL 319
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 27-378 9.27e-06

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 47.21  E-value: 9.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  27 LNTIYMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCSTTLLNFFHGWPWYAVWLVMLGF 106
Cdd:cd17316    22 APVLAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGI 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 107 GGGMIIPAIYAMAGAVWPNGGRQTFNAIYLAqniGVAVGAAMGGFVAeFSFNYIFLANLIMYIVFALVAITQFNIEIKAK 186
Cdd:cd17316   102 GIGGEYPGASTYVAEFAPSKRRGFALGLLQS---GWALGALLAALVA-SLLIPLLSGDWGWRILFLIGALPALLALLLRR 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 187 vkypthlditgkknkaRFISLVLICAMFAICWVAYIQWESTIasFTQSINISMAQYSVLWTINGIMILVAQPLIKPILYL 266
Cdd:cd17316   178 ----------------RTLLLILLWFFISFGYYGLTTFLPTY--LQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDR 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 267 LkgDLKKQMFVGIVIF--MLSFFVTSFAENFTIFVVGMIILTFGEMFVWPAVPTIANQLAPEGKQGQYQGFVNSAATVGK 344
Cdd:cd17316   240 I--GRKKTLVIGLILSgiLALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGG 317

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1539804673 345 AFGPFLGGVLVDA--FNMRMMFIGMMVLLVFALILL 378
Cdd:cd17316   318 GGAPPLIALLLAStgGTGVPALILALLAIVALIVAL 353
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 225-390 1.09e-05

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 47.37  E-value: 1.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 225 ESTIASFTQSI---NISMAQYSVLWTINGIMilVAQPLIKPILYLL--KGDLKKQMFVGIVIFMLSFFVTSFAENFTIFV 299
Cdd:TIGR00711  17 DSTIVNVAIPTiagDLGSSLSQVQWVITSYM--LANAISIPLTGWLakRFGTRRLFLISTFAFTLGSLLCGVAPNLELMI 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 300 VGMIILTFGEMFVWPAVPTIANQLAPEGKQGQYQGFVNSAATVGKAFGPFLGGVLVDAFNMRMMFIGMMVLLVFALIL-L 378
Cdd:TIGR00711  95 IFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVVaF 174

                         170
                  ....*....|..
gi 1539804673 379 MIFKESNEQTKK 390
Cdd:TIGR00711 175 FILPRDKPAASE 186
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
200-382 1.30e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 46.77  E-value: 1.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 200 NKARFISLVLICAMFAICWVAYIQWESTIASFTQSINISMAQYSVLWTINGIMILVAQPLIKPILYLLkgDLKKQMFVGI 279
Cdd:COG0738     3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRF--GYKRGLLLGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 280 VIFMLSFFVTSFAENFTIFVVGMIILTFGEMFVWPAVPTIANQLAPEgKQGQYQGFVNSAATVGKAFGPFLGGVLVDA-- 357
Cdd:COG0738    81 LLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPE-TAASRLNLLHAFFSLGALLGPLLGGLLILLgl 159

                         170       180
                  ....*....|....*....|....*.
gi 1539804673 358 -FNMRMMFIGMMVLLVFALILLMIFK 382
Cdd:COG0738   160 sLSWHLPYLILAVLLLLLALLFLRSK 185
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 10-378 1.31e-05

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 46.78  E-value: 1.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  10 LVIGMALNITGSSFLWPLNTIYMKQElGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCSTTLLN 89
Cdd:cd17477     1 LLLSVALLGLGSGLLLPLLSLRLERE-GVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  90 FFHGWPWYAVWLVMLGFGGGMIIPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVAVGAAMGGFVAEFSFNYIFLANLIMY 168
Cdd:cd17477    80 LTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYsTVLGLGFALGPLLLALVGTAGALPFLIAAVLLL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 169 IVFALVAITQfnieiKAKVKYPTHLDITGKKNKARFISLVLICAMFAICWVAYIqweSTIASFTQSINISMAQYSVLWTI 248
Cdd:cd17477   160 LALVPLLLTR-----RAAPEIEEAESISLRRLLRIAPLALLGAFVAGFLEGAFY---SLLPLYGLRLGLSVAQAALLLAA 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 249 NGIMILVAQPlikPILYLL-KGDLKKQMFVGIVIFMLSFFVTSFAENFTIFVVGMIILTFGEMF-VWPAVPTIANQLAPE 326
Cdd:cd17477   232 FVLGGLLLQW---PLGWLAdRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGpLYTLALALAGDRLPG 308

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1539804673 327 GKQGQYQGFVNSAATVGKAFGPFLGGVLVDAFNMRMMFIGMMVLLVFALILL 378
Cdd:cd17477   309 DELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 30-176 1.58e-05

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 46.40  E-value: 1.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  30 IYMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYK-TILIGTLTCLCSTTLLNFFH---GWPWYAVWLVMLG 105
Cdd:cd17502   192 LYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKpLIVIGTILMSVGAGLLTTLTldtSKWLLIGYLILLG 271

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1539804673 106 FGGGMIIPA-IYAMAGAVWPNGGRQTFNAIYLAQNIGVAVGAAmggfvaefsFNYIFLANLIMYIVFALVAI 176
Cdd:cd17502   272 LGLGIGFQQpLVAVQNAVPPADVGVATATNTFFRSLGGTLGVA---------ITDVFLVALALAALAFLLSL 334
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 272-382 3.63e-05

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 45.25  E-value: 3.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 272 KKQMFVGIVIFMLSFFVTSFAENFTIFVVGMIILTFGEMFVWPAVPTIANQLAPEGKQGQYQGFVNSAATVGKAFGPFLG 351
Cdd:cd17319    68 RKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLS 147

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1539804673 352 GVLVDAFNMRMMFIGMMVL-LVFALILLMIFK 382
Cdd:cd17319   148 GWLLLLFGWRWAFIIEGLLgLLLAVLWWFYLR 179
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 31-378 4.59e-05

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 45.31  E-value: 4.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  31 YMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCSTTLLNFFHGWPWYAVWLVMLGFGGGM 110
Cdd:cd17475    21 FLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGS 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 111 IIPA-IYAMAGAVWPN------GGRQTfnaiylAQNIGVAVGAAMGGFVAE-FSFNYIFLANLIMYIVFALVAITQF-NI 181
Cdd:cd17475   101 VQPGgGRAIMRWFPPRerglamGIRQT------GVPLGGALAAALLPPLALhYGWRAAFVVAGLVSILAAVLFWLFYrEP 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 182 EIKAKVKYPTHLDITGKKNKARFISLVLIC-AMFAICWVAYIQWESTIASFTQSINISMAQYSVLWT---INGIMILVAQ 257
Cdd:cd17475   175 PAASAATESASTLLRSLKEVLRNRDVWLIAiAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAvaqLGGALGRIGL 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 258 PLIKPilYLLKGDLKKQMFVGIVIFMLSFFVTSFAENFTIFVVGMIILTFGEMFV--WPAVP-TIANQLAPEGKQGQYQG 334
Cdd:cd17475   255 GRVSD--RVFGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAigWNGLYlTLVAESAGPEQAGTALG 332

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1539804673 335 FVNSAATVGKAFGPFLGGVLVDA-FNMRMMFIGMMVLLVFALILL 378
Cdd:cd17475   333 LANTINFIGIAIGPPLFGLLVDAtHSYAPAWLALALLLVLAALLL 377
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 33-381 6.06e-05

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 44.60  E-value: 6.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  33 KQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCSTTLLNFFHGWPWYAVWLVMLGFGGGMII 112
Cdd:cd17371    26 IAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEW 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 113 PAIYAMAGAVWPNGGRQT-FNAIYLAQNIGVAVGAA-----MGGFVAEFSFNYIFLANLIMYIVFALV-------AITQF 179
Cdd:cd17371   106 AAGAALMAEYVPARHRGKaLGYVQSGWAVGWLLATLlaallFPLLPPEIAWRVLFLLGALPALLVLFIrrfvkepPQWQA 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 180 NIEIKAKVKYPTHLDITGKKNKAR---FISLVLICAMFAicWVAYIQWESTIASFTQSINI-SMAQYSVLWTINGIM-IL 254
Cdd:cd17371   186 ARAARRHFADRPSLRELFSPPLLRttlLASLLATGALGG--YYGITTWLPSYLTGERGLSFeGSAGYLVVTILGGFLgYL 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 255 VAQPLIKPI----LYLLkgdlkkqMFVGIVIFMLSFFvtSFAENFTIFVVGMIILTFGEMFVWPAVPTIANQLAPEGKQG 330
Cdd:cd17371   264 AGGFLADRIgrrnNFAL-------FALGSAISILLYF--FLPLSPTLILILGFPLGFFASGPFSGMGAYLTELFPTAVRA 334

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1539804673 331 QYQGFVNSAATVGKAFGPFLGGVLVDAFNMRMMfIGMMVLLVFALILLMIF 381
Cdd:cd17371   335 TAQGFCYNVGRIIGALFPFLVGFLATSGSLGTA-IAVFAAVYYIAGLVLAL 384
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 32-155 7.13e-05

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 44.65  E-value: 7.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  32 MKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCSTTLLNFFHGWPWYAVWLVMLGFGGGMI 111
Cdd:TIGR00895  43 ISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGL 122

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1539804673 112 IPAIYAMAGAVWPNGGRQTFNAIYLaqnIGVAVGAAMGGFVAEF 155
Cdd:TIGR00895 123 MPNLNALVSEYAPKRFRGTAVGLMF---CGYPIGAAVGGFLAGW 163
PRK10091 PRK10091
MFS transport protein AraJ; Provisional
 9-175 7.96e-05

MFS transport protein AraJ; Provisional


Pssm-ID: 182234 [Multi-domain]  Cd Length: 382  Bit Score: 44.31  E-value: 7.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673   9 WLVIGMALNITGSSFLW-PLNTIYMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCSTTL 87
Cdd:PRK10091  202 WLIFAATMFGNAGVFAWfSYIKPYMMFISGFSETSMTFIMMLVGLGMVLGNLLSGRLSGRYSPLRIAAVTDFIIVLALLM 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  88 LNFFHGWPWYAVWLVMLGFGGGMIIPAIYAMAGAVWPNGGRQTFNA-IYLAQNIGVAVGAAMGGFVAEFSFNYIFLANLI 166
Cdd:PRK10091  282 LFFFGGMKTASLIFAFICCAGLFALSAPLQILLLQNAKGGELLGAAgGQIAFNLGSAIGAYCGGMMLTLGLAYNYVALPA 361


                  ....*....
gi 1539804673 167 MYIVFALVA 175
Cdd:PRK10091  362 ALLSFAAMS 370
MFS_MosC_like cd17393
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ...
 4-175 8.56e-05

Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340951 [Multi-domain]  Cd Length: 373  Bit Score: 44.17  E-value: 8.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673   4 PKSVWWL-VIGMALNIT-GSSFLWplNTIYMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTC 81
Cdd:cd17393   198 NRLLLLLgLLALAAALAeGAAADW--SALYLRDVLGASAALAALGYAVFSLAMTVGRLFGDRLVDRFGDVAVLRAGALLA 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  82 LCSTTLLNFFHGWPWYAVWLVMLGFGGGMIIPAIYAMAGAVWPNGGRQTFNAIYLAQNIGVAVGAAMGGFVAE-FSFNYI 160
Cdd:cd17393   276 ALGLLLALLAPSVWVALAGFALMGLGLSVVVPLAFSAAGALPGLAAGIAVARVATLGYLGFLVGPPLIGFLADaTGLRTA 355

                         170
                  ....*....|....*
gi 1539804673 161 FLANLIMYIVFALVA 175
Cdd:cd17393   356 FLVVALLALLVALLA 370
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 270-378 8.96e-05

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 44.09  E-value: 8.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 270 DLKKQMFVGIVIFMLSFFVTSFAENFTIFVVGMIILTFGEMFVWPAVPTIANQLAPEGKQGQYQGFVNSAATVGKAFGPF 349
Cdd:cd17502    58 GRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPL 137

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1539804673 350 LGGVLVDAFNMRMMF-----IGMMVLLVFALILL 378
Cdd:cd17502   138 IGGAFTDHLSWRWCFyinlpIGGLALALLRTILL 171
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 232-381 1.24e-04

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 43.70  E-value: 1.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 232 TQSINISMAQysVLWTINGIMILVAqplikpILYLLKGDL-----KKQMF-VGIVIFMLSFFVTSFAENFTIFVVGMIIL 305
Cdd:cd17321    23 ARDLGASPSQ--LQWVVNAYLLAFA------ALLLLAGRLgdrfgRKRVFlIGLALFGLASLLCALAPSLAFLIAARALQ 94

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1539804673 306 TFGEMFVWPAVPTIANQLAPEGKQGQYQGFVNSAATVGKAFGPFLGGVLVDAFNMRMMFIGMMVLLVFALILLMIF 381
Cdd:cd17321    95 GIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLARTF 170
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 5-176 1.33e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 43.57  E-value: 1.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673   5 KSVWWLVIGMALNITGSSFLWPLNTIYMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTIL-IGTLTCLC 83
Cdd:cd06174   203 PGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLlIGLLLMAL 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  84 STTLLNFFHGWPWYAVWLVMLGFGGGMIIPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVAVGAAMGGFVAE--FSFNYI 160
Cdd:cd06174   283 GLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLnTFGFLGGAIGPLLAGFLLAatFGLTGA 362

                         170
                  ....*....|....*.
gi 1539804673 161 FLANLIMYIVFALVAI 176
Cdd:cd06174   363 FLVLAVLLLLAAILLL 378
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 275-381 1.64e-04

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 43.41  E-value: 1.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 275 MFVGIVIFMLSFFVTSFAENFTIFVVGMIILTFGEMFVWPAVPTIANQLAPEGKQGQYQGFVNSAATVGKAFGPFLGGVL 354
Cdd:cd17391   273 LLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAI 352

                          90       100
                  ....*....|....*....|....*..
gi 1539804673 355 VDAFNMRMMFIGMMVLLVFALILLMIF 381
Cdd:cd17391   353 AAHFGYRAVFVVTALLVLLNAIWSFIF 379
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 59-347 1.71e-04

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 43.40  E-value: 1.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  59 LLGGSLFDKLGGYKTILIGTLTcLCSTTLLN-FFHGWPWYAVWLVMLGFGGGMIIPAIYAMAGAVWPNGGRQT--FNAIY 135
Cdd:cd17476    51 LIFGRLGDIYGHKKMFVIGSFW-FAIWSLIAgFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNivFSLFG 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 136 LAQNIGVAVGAAMGGFVAEF-SFNYIFLANLIMYIVFALVAITQFNieikakvkypthlditgkknkaRFISLVLICAMF 214
Cdd:cd17476   130 ATAPLGFALGGVFGGLFAQLaWWPWIFWFLAILAAIVAVAAIFWTS----------------------PSFIAVLLAVFL 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 215 aiCWVAYIQWESTIASFTQSIN-----ISMAQYSVLwTINGIMILVAQPLI---KPILYLlkgdlkkqMFVGIVIFMLS- 285
Cdd:cd17476   188 --GWASFGIWVFYATQYFQNVRgysplLTSARFIPM-AIGGVLAAITVGFLiarLPPSYI--------MAISMVAFLVGp 256

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1539804673 286 -FFVTSFAEN--FTIFVVGMIILTFGEMFVWPAVPTIANQLAPEGKQGQYQGFVNSAATVGKAFG 347
Cdd:cd17476   257 iLFATMPVHQtyWAQAFPAMIVAPFGMDFSFPAATIIASNAVPREYQGLAGSLVNTVVNYGISIG 321
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 5-176 2.01e-04

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 42.98  E-value: 2.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673   5 KSVWWLVIGMALNITGSSFLWPLNTIYMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKT-ILIGTLTCLC 83
Cdd:cd17353   213 PTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTlSIAFLIQGVA 292

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  84 STTLLNFFHGWPWYAVWLVMLGFGGGMIIPAIYAMAGAVW-PNGGRQTFNAIYLAQNIGVAVGAAMGGFV-AEFSFNYIF 161
Cdd:cd17353   293 MFLLPFIGSVAVLFVLGVALIGFCYGGGFALFPALTADFFgTKNAGTNYGLLYTAKGVGGLIGPIIAAYVlYTGGYNAAF 372

                         170
                  ....*....|....*
gi 1539804673 162 LANLIMYIVFALVAI 176
Cdd:cd17353   373 IIAAALSLVALALAL 387
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
 272-379 3.43e-04

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 42.45  E-value: 3.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 272 KKQMFVGIVIFMLSFFVTSFAENFTIFVVGMIILTFGEMFVWPAVPTIANQLAPEGKQGQYQGFVNSAATVGKAFGPFLG 351
Cdd:COG2270   304 KRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQALSRSLLARLIPPGREAEFFGLYALSGKAASFLGPLLF 383

                          90       100
                  ....*....|....*....|....*....
gi 1539804673 352 GVLVDAF-NMRMMFIGMMVLLVFALILLM 379
Cdd:COG2270   384 GLVTQLTgSQRLGILSLIVFFVIGLVLLL 412
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 14-178 3.64e-04

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 42.99  E-value: 3.64e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673   14 MALNITGSSFLWPLNTI-------YMKQELGKSLT-VAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCST 85
Cdd:PRK08633   234 LWLAIIGLSYFWFISQLaqanfpaYAKEVLGLDNTfQVQYLLAASAIGIGIGSLLAGRLSGRHIELGLVPLGALGLALSL 313

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673   86 TLLNFFHGWPWYAVWLVMLGFGGGMIIPAIYAMAGAVWPNGGR-QTFNAIYLAQNIGVAVGAAMGGFVA--EFSFNYIFL 162
Cdd:PRK08633   314 FLLPTAPSLASVLVLFFLFGFSAGLFIVPLNALIQFRAPEKELgKVLAANNFLQNVGMLLFLALTTLFSglGLSPAGLFY 393

                          170
                   ....*....|....*.
gi 1539804673  163 ANLIMYIVFALVAITQ 178
Cdd:PRK08633   394 LIALVTLIGTLYTLLL 409
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 272-383 4.81e-04

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 41.84  E-value: 4.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 272 KKQMFVGIVIFMLSFFVTSFAENFTIFVVGMIILTFGEMFVWPAVPTIANQLAPEGKQGQYQGFVNSAATVGKAFGPFLG 351
Cdd:cd17328    64 KWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVG 143

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1539804673 352 GVLVDAF-NMRMMFIGMMVLLVFALILLMIFKE 383
Cdd:cd17328   144 GLVAQATgGWRWAFRVTGVLGVLLAILLLLFVR 176
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 5-177 4.85e-04

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 41.79  E-value: 4.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673   5 KSVWWLVIGmalNITGSSFLWPLNT---IYMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKL--GGYKTILIGTL 79
Cdd:cd17319   179 RQVWGLALG---YFGINYALYGLLTwlpTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrGARRLVIIIGL 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  80 TCLCSTTLLNFFHGWPWYAV-WLVMLGFGGGMIIPAIYAMAGAVWPNGGRQTFNAIY-LAQNIGVAVGAAMGGFVAEF-- 155
Cdd:cd17319   256 LLAAVGLLLAYLTTSPVVAViLLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLInSGGNLGGFVAPLLIGYLVDAtg 335

                         170       180
                  ....*....|....*....|..
gi 1539804673 156 SFNYIFLANLIMYIVFALVAIT 177
Cdd:cd17319   336 SYTAAFLFLAAVALLAALLVLL 357
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 4-119 5.85e-04

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 41.79  E-value: 5.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673   4 PKSVWWLVIGMALNITGSsFLWPLNT-IYMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCL 82
Cdd:cd17473   196 WKRVLPIYFLAFLAMLLF-YVIPIQLpFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMA 274

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1539804673  83 CSTTLLNFFHGWPWYAVWLVMLGFGGGMIIPAIYAMA 119
Cdd:cd17473   275 LGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWA 311
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 44-381 6.13e-04

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 41.43  E-value: 6.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  44 GLVLMINSFGMVIGNLLGGSLFDKLGGYKTILI-GTLTCLCSTTLLNFFHGWPWYAVWLVML-----GFGGGMIIPAIYA 117
Cdd:cd17326    39 GWVVAAYSLGQLVFSPVFGYWSNKTSSVKEPLIvSILIAIVGNILYALAEYFPSNRKYVMLVarfliGVGAGNVAVLRAY 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 118 MAGAVWPNGGRQTFNAIYLAQNIGVAVGAAMGGFVAEFSFN-YIFLANLI--MYIVFALVAItqfnieikakvkypthld 194
Cdd:cd17326   119 VAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFTPIGYPgYVIGIKLRfnMYTAPAWLMA------------------ 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 195 ITGkknkarFISLVLICAMF--AICWVAYIQWESTIASFTQSINI-SMAQYSvlWT------INGIMILVAQPLIKPILY 265
Cdd:cd17326   181 ILG------IINIILILFFFkeVVCIFLFFVVLFIFANLETIGTPlTMDMYG--WTreeavlYNGIILAVSGVLSVLVFL 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 266 LLK------GDLKKQMFVGIVIFMLSFFVTsfaenFTIFVVGMIILTFGEMFVWPAVPTIANQLAPEGKQGQYQGFVNSA 339
Cdd:cd17326   253 LFKflslglIDERKILLGGLILFFLGFVVT-----LPWGITGVILFGLGYPIGNVMLYTLYSKILGPKPQGTMQGVLTAS 327

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 1539804673 340 ATVGKAFGPFLGGVLVDAFNMRMMFIGMMVLLVFALILLMIF 381
Cdd:cd17326   328 GSLARTLGPIFVTAIYTHFGPRWTWIITLGLLLLAIILLIVF 369
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 26-118 6.84e-04

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 41.39  E-value: 6.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  26 PLNTIYMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCSTTLLNFFHGWPWYAVWL--VM 103
Cdd:cd17380    19 PIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLILsrIL 98

                          90
                  ....*....|....*
gi 1539804673 104 LGFGGGMIIPAIYAM 118
Cdd:cd17380    99 LGLGEGVHFPSMTSL 113
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 269-377 8.40e-04

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 41.02  E-value: 8.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 269 GDL--KKQMFVGI-VIFMLSFFVTSFAENFTIFVVGMIILTFGeMFVWPAVPTIANQLAPEGKQGQYQGFVNSAATVGKA 345
Cdd:cd17504    55 GDLygRKKVLLIVlAIYTAGSLLAAFAPNLPVLIAGRALQGIG-GAVFPLAFALVREEFPPERVPVAQGILSATFGIGAG 133

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1539804673 346 FGPFLGGVLVDAFNMRMMFIGMMVLLVFALIL 377
Cdd:cd17504   134 IGLPLGGWIVQHLGWRWIFWTAAPVAVLLAAL 165
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 26-154 9.26e-04

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 41.07  E-value: 9.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  26 PLNTIYMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCSTTLLNFF--HGWPWYAVWLVM 103
Cdd:cd17318    41 KDTLPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAarGGYGALIVLRIL 120

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1539804673 104 LGFGGGMIIPAIYAMAgAVW--PNGGRQTFNAIYLAQNIGVAVGAAMGGFVAE 154
Cdd:cd17318   121 QGLAQGVTFPAMHALW-AKWapPLERSRLTSIAYSGSQFGTVIAMPLSGFLCE 172
PRK03545 PRK03545
putative arabinose transporter; Provisional
 280-376 1.12e-03

putative arabinose transporter; Provisional


Pssm-ID: 179591 [Multi-domain]  Cd Length: 390  Bit Score: 40.64  E-value: 1.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 280 VIFMLSFFVTSFAENFTIFVVGMIILTFGEMFVWPAVPTIANQLAPEGKQGQYQGFVNSAATVGKAFGPFLGGVLVDAFN 359
Cdd:PRK03545   82 VLFIASHVLSALAWNFTVLLISRIGIAFAHAIFWSITASLAIRVAPAGKKAQALSLLATGTALAMVLGLPLGRVIGQYLG 161

                          90
                  ....*....|....*....
gi 1539804673 360 MRMMF--IGMMVLLVFALI 376
Cdd:PRK03545  162 WRTTFlaIGGGALITLLLL 180
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 272-381 1.55e-03

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 40.25  E-value: 1.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 272 KKQMFVGIVIFMLSFFVTSFAENFTIFVVGMIILTFGEMFVWPAVPTIANQLAPEGKQGQYQGFVNSAATVGKAFGPFLG 351
Cdd:cd17320    64 RPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLG 143

                          90       100       110
                  ....*....|....*....|....*....|
gi 1539804673 352 GVLVDAFNMRMMFIGMMVLLVFALILLMIF 381
Cdd:cd17320   144 GLLLLFFGWRAIFVFLALLGLLLLLLVLLF 173
PRK14995 PRK14995
SmvA family efflux MFS transporter;
12-175 1.78e-03

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 40.48  E-value: 1.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  12 IGMALNITGSSFLWPLNtIYmkqelgkSLTVAGLVLMInsfgmvignllgGSLFDKLGGYKTILIGTLTCLCSTTLLNFF 91
Cdd:PRK14995   32 LSMTLGASGNELLWIID-IY-------SLVMAGMVLPM------------GALGDRIGFKRLLMLGGTLFGLASLAAAFS 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  92 HGWPWYAVWLVMLGFGGGMIIPAIYA-------------MAGAVWPNGGrqtfnaiylaqNIGVAVGAAMGGFVAE-FSF 157
Cdd:PRK14995   92 PTASWLIATRALLAIGAAMIVPATLAgiratfteekqrnMALGVWAAVG-----------SGGAAFGPLVGGILLEhFYW 160

                         170
                  ....*....|....*....
gi 1539804673 158 NYIFLANL-IMYIVFALVA 175
Cdd:PRK14995  161 GSVFLINVpIVLVVMGLTA 179
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 10-176 1.84e-03

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 40.25  E-value: 1.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  10 LVIGMALNITGSSFLWPLNTIYMkqeLGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCSTTLLN 89
Cdd:cd17504   189 AGFGMFMVFQLLPQLLQLPTPTG---FGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLA 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  90 FFHGWPWYAVWLVMLGFGGGMIIPAIYA--MAGAVWPNGGRQTFNAIYLAQNIGVAVGAAMGGFV--------------A 153
Cdd:cd17504   266 LLHSSLWALVVALLLIGIGLGLAFASLPniVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAIlttytvsitsggvpT 345

                         170       180
                  ....*....|....*....|...
gi 1539804673 154 EFSFNYIFLANLIMYIVFALVAI 176
Cdd:cd17504   346 EGAYVLAFLIGAALALAALLLSL 368
PRK05122 PRK05122
major facilitator superfamily transporter; Provisional
 10-112 2.04e-03

major facilitator superfamily transporter; Provisional


Pssm-ID: 235348 [Multi-domain]  Cd Length: 399  Bit Score: 39.87  E-value: 2.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  10 LVIGMALNITgssflwplnTIYMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCS---TT 86
Cdd:PRK05122   29 LTIGLPLAVL---------PGYVHDQLGFSAFLAGLVISLQYLATLLSRPHAGRYADTLGPKKAVVFGLCGCALSgllYL 99

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1539804673  87 LLNFFHGWPWYAVWL-----VMLGFGGGMII 112
Cdd:PRK05122  100 LAGLLAAWPVLSLLLlllgrLLLGIGESLAG 130
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 7-381 2.45e-03

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 39.90  E-value: 2.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673   7 VWWLVIGMALNItGSSFLWPLNTIYMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCSTT 86
Cdd:cd17353     5 VLLGAVLMHLIL-GYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFI 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  87 LLNFF-HGWPWYAVWLVMLGFGGGMIIPAIYAMAGAVWPNggrqtfnaiylaqNIGVAVGAAMGGFVAEfSFNYIFLANL 165
Cdd:cd17353    84 LSAFAiSLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPD-------------KRGLATGIVIAGFGLG-SLIFSPLIAY 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 166 IM-------------YIVFALVAITQFNIEIKAKVKYPTHLDITGKKNKARFISL-----------VLICAMFAICWVAY 221
Cdd:cd17353   150 LIntvgvpttflilgIIFLIIIVIGAFLIRDPPKGWVPPGVDPLANNAENSPRDYtpremlrtptfWLLWLMFFLNATAG 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 222 IQWESTIASFTQSIN-ISMAQYSVLWTINGIMILVAQPLIkPILYLLKGDLKKQMFVGIVIFMLSFFVTSFAENFTIFVV 300
Cdd:cd17353   230 LMLIGQAKPIGQEFAgLDAGIAALAVSILSIFNGGGRPFW-GWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVL 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 301 GMII--LTFGEMFvwPAVPTIANQLAPEGKQGQYQGFVNSAATVGKAFGPFLGGVLVDAFNMRMMFIGMMVLLVFALILL 378
Cdd:cd17353   309 GVALigFCYGGGF--ALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALA 386


                  ...
gi 1539804673 379 MIF 381
Cdd:cd17353   387 LLL 389
MFS_1_like pfam12832
MFS_1 like family; This family contains proteins related to the MFS superfamily.
 24-365 2.74e-03

MFS_1 like family; This family contains proteins related to the MFS superfamily.


Pssm-ID: 432817 [Multi-domain]  Cd Length: 362  Bit Score: 39.54  E-value: 2.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  24 LWPLNTIYMKQeLGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCSTTLLNFFHGWPWYAVWLVM 103
Cdd:pfam12832  18 LLPYWGLYLRS-IGLNPSEIGLITAILPLTRILAPPIWGWLADRTGKRKAVVRLASILAAVLFLSVLFIPISLTFWWLAL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 104 LGFGGGMIIPAIYAMAGAV---WPNGGRQTFNAIYLAQNIGVAVGAAMGGFVAEFSfNYIFLANLIMYIVFALVAITQFN 180
Cdd:pfam12832  97 LVVLFSFFWNAILPQFEVAtlqHLGEKRKDYGRQRLWGSVGFALSVFGLGALFDHY-SVGLLPSVLFYLFAALMLLSLLL 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 181 IEIKAKVKYPTHLDITGKKNKARF----ISLVLICAMFAICWVAYiqwESTIASFTQSINISMAQYSVLWTINGIMILva 256
Cdd:pfam12832 176 PLAPPEMEYESKGGSKAVFWNLLKqpevIIFFLAAFLLGFSHGPF---YTFLFLYLENLGASNTLLGALWALGVVAEI-- 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 257 qplikPILYLLKGDLKK-----QMFVGIVIFMLSFFVTSFAENFTIFVVGMIIL---TFGemFVWPAVPTIANQLAPEGK 328
Cdd:pfam12832 251 -----PLFFYAHRLLRRfghrnLLIIALLLTALRWLLYAFFVENPWLVLPIQFLhaiSFG--LTHAAAIEYVRRIFPGSL 323

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1539804673 329 QGQYQGFVNSAA-TVGKAFGPFLGGVLVDAFNMRMMFI 365
Cdd:pfam12832 324 QGTGQALYSGLYfGLGGALGSLIGGQLWDLFGARFTFR 361
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 34-174 3.16e-03

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 39.11  E-value: 3.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  34 QELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIG-TLTCLCSTTLLNFFHGWPWYAVWLVMLGFGGGMII 112
Cdd:cd17365   199 VEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFfALGAVSLALLGVSPASLVLLYVLVFLAGACVNGAQ 278

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1539804673 113 PAIYAMAGAVWPNGGRQTFNAIYLA-QNIGVAVGAAMGGFV--AEFSFNYIFLANLIMYIVFALV 174
Cdd:cd17365   279 VGLYALAARFYPTEVRATGVGWALGvGRLGAILGPLLGGLLlaAGLGPESVFLALAIPAALGALA 343
MFS_NRT2_like cd17341
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ...
 23-379 3.28e-03

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340899 [Multi-domain]  Cd Length: 384  Bit Score: 39.16  E-value: 3.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  23 FLWPLNTIYMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCSTTLLNFFHGWPWYAVWL- 101
Cdd:cd17341    16 FLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAVSSYWGLLVLg 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 102 VMLGFGGGMIIPAIYaMAGAVWPNGGRQTFNAIYL-AQNIGVAVGA--------AMGGFVAEFSFNYIFLANLIMYIVFA 172
Cdd:cd17341    96 FLLGFAGANFASGQP-WASFWFPKEKIGGAAGGIAgAGNMGVAVSQllapliagAIVFDGGFVGWRNAFFVPGILLAIAA 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 173 LVAItqFNIEIKAKVKYPTHLDITGKKNKARFISLVLICAMFAICWVAYIQWESTIASFTQSINISMAQYSVLWTINGIM 252
Cdd:cd17341   175 VLVL--LFGDDLPTGKASALEFLKVQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAGILAALFPL 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 253 I-LVAQPlIKPILYLLKGDLKKQMFVGIVI----FMLSFFVTSFAENFTIFVVGMIILTFGEMFVWPAVPTIANQLAPEg 327
Cdd:cd17341   253 AgALARP-AGGWLSDRFGGRRRLWWLFIVMtigaALLSLSLPTSGTNLVLFLALFVALGLGAGAGNGSVFRMVPFIFRR- 330

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1539804673 328 KQGQYQGFVNSAATVGKAFGPFLGGVLVDAFNMRMMFIGMMVLLVFALILLM 379
Cdd:cd17341   331 ELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACTLLV 382
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 31-176 4.06e-03

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 38.90  E-value: 4.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  31 YMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCSTTLLNFFHGWPWYAVWLVMLGFGGGM 110
Cdd:TIGR00881  20 YLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGM 99

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1539804673 111 IIPAIYAMAGAVWPNGGRQTFNAIYlaqNIGVAVGAAMGGFVAEFSFNYiFLANLIMYIVFALVAI 176
Cdd:TIGR00881 100 GWPPCGRTVTKWFSRSERGTWVSFW---NCSHNVGGGLLPPLVLFGIAE-LYSWHWVFIVPGIIAI 161
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 238-378 6.24e-03

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 38.41  E-value: 6.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 238 SMAQYSVLWTINGIMILVAQPLIKPILyllKGDLKKQMFVGIVIFMLSFFVTSFAENFTIFVVGMIILTFGEMFVWPAVP 317
Cdd:cd17389   250 SMQQGKMFFFIGIIMALVQGGYVRRIK---PGKEKKAVLQGLILLIPAFLLIGWASSVTVLYAGLFLYSFAAATVVPCLT 326

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1539804673 318 TIANQLAPEGKQGQYQGFVNSAATVGKAFGPFLGGVLVDAFNMRMMFIGMMVLLVFALILL 378
Cdd:cd17389   327 TLVSGYGSDDQKGTVMGIFRSLGALARALGPIVACTVYWLAGSEACYTIGALLFLLPLLLL 387
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 34-174 6.67e-03

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 38.33  E-value: 6.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  34 QELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCSTTLLNFFHGWPWYAVWLVMLGFGGGMIIP 113
Cdd:cd17358    34 LSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASV 113

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1539804673 114 AIYAMAGAVWPNGGRQTFNA-IYLAQNIGVAVGAAMGGFVaefsfNYIFLANLIMYIVFALV 174
Cdd:cd17358   114 VVPVYIAEIAPKNVRGALGSlNQLLVNIGILLGYVLGSFL-----PWRTLALIGAIPPVVFL 170
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 3-173 7.72e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 37.94  E-value: 7.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673   3 IPKSVWWLVIGMALNITGSSFLWPLNTIYMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTIL-IGTLTC 81
Cdd:cd17330   172 FLPPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLrLGLLLA 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  82 LCSTTLLNFFHGWPWYAVWLVMLGFGGGMIIPAIYAMAGAVWPNGGRQTFNAIYLA-QNIGVAVGAAMGGFVAEFSFNY- 159
Cdd:cd17330   252 IIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSlQSLARIIGPLLAGPLYSFLGPGv 331

                         170
                  ....*....|....*
gi 1539804673 160 -IFLANLIMYIVFAL 173
Cdd:cd17330   332 pFLLAAGLLLIALFL 346
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 9-176 7.83e-03

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 38.28  E-value: 7.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673   9 WLVIGMALNITGSSFLWPLNTI-YMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLtcLCSTTL 87
Cdd:cd17369   231 LLAIGLRLAENVLFYLFTTFALsYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGAL--LAALFA 308

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  88 LNFFHGWPWYAVWLVMLGF--GGGMIIPAIYAMAGAVWPN--GGRQTFNAIYLAQNIGVAVGAAMGGFVAE--FSFNYIF 161
Cdd:cd17369   309 FPFFWLLDTGSTWLIVLAAvvVLGVLHGMMYGPQAAFLAElfPTRVRYTGASLGYQLGAILGGGFAPLIATalVAATGSW 388

                         170
                  ....*....|....*
gi 1539804673 162 LANLIMYIVFALVAI 176
Cdd:cd17369   389 WPVALYLAALAVISL 403
MFS_SLC18B1 cd17385
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ...
 37-381 7.86e-03

Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340943 [Multi-domain]  Cd Length: 390  Bit Score: 37.97  E-value: 7.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  37 GKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCSTTLLNFFHGWPWYAVWLVML-------GFGGG 109
Cdd:cd17385    30 GVSDTIIGLVFGCFALVIFLTSPIFGKYLVKIGAKFMFVAGMFVSGGCTILFGFLDRVPDGTVFIALCflvriveAVGFA 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 110 MIIPAIYAMAGAVWPNGGRQTFNAIYLAQNIGVAVGAAMGGFVAE-FSFNYIFLANLIMYIVFALVAITQFnieikakvk 188
Cdd:cd17385   110 AFITASFAIIAKEFPNNIATVLGTLETFSGLGLMLGPPLGGFLYQaGGYELPFLVLGCLLLLTVPLNMFIL--------- 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 189 yPTHLDITGKKNKA-----RFISLVLICAMFAICWVAYIQWESTIASFTQSINISMAQYSVLWTINGIMILVAQPLIKPI 263
Cdd:cd17385   181 -PRYDDDPSPKSGSmlkllKIPSVLLLCLSIVSGSVSLGFLDPTLSPHLRQFKLSPGQVGLMFLILAGSYAISAPLWGWL 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673 264 LYllKGDLKKQMFV-GIVIFMLSFF------VTSFAENFTIFVVGMIILTFGEMFVwpAVPTIANQLA-------PEG-- 327
Cdd:cd17385   260 SD--KKKIPKWLMViGSIITGVGFLllgpapLLPIKSELWMVIIGLVLLGLSLGAA--LVPTFPELLNcareygfPDNls 335

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1539804673 328 KQGQYQGFVNSAATVGKAFGPFLGGVLVDAFNMRMMFIGMMVLLVFALILLMIF 381
Cdd:cd17385   336 TYGLVSGLFNAAFSLGAFIGPTLGGFLLERLGFEWAATIQAGLAFVVGILMSIY 389
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 31-146 9.72e-03

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 37.67  E-value: 9.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539804673  31 YMKQELGKSLTVAGLVLMINSFGMVIGNLLGGSLFDKLGGYKTILIGTLTCLCSTTLLNFFHGWPWYAVWlvmLGFGGGM 110
Cdd:cd17371   235 YLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPTLILI---LGFPLGF 311

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1539804673 111 IIPAIYAMAGA----VWPNGGRQTfnAIYLAQNIGVAVGA 146
Cdd:cd17371   312 FASGPFSGMGAylteLFPTAVRAT--AQGFCYNVGRIIGA 349
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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