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Conserved domains on  [gi|1539159416|gb|AZP56029|]
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E4 orf 3/4 [Vector AdCFP]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Adeno_E4 super family cl05114
Mastadenovirus early E4 13 kDa protein; This family consists of human and simian ...
34-55 7.01e-10

Mastadenovirus early E4 13 kDa protein; This family consists of human and simian mastadenovirus early E4 13 kDa proteins. Human adenovirus type 9 (Ad9) is unique in eliciting exclusively estrogen-dependent mammary tumours in rats and in not requiring viral E1 region transforming genes for tumorigenicity. E4 codes for an oncoprotein essential for tumourigenesis by Ad9.


The actual alignment was detected with superfamily member pfam05385:

Pssm-ID: 283128  Cd Length: 108  Bit Score: 50.07  E-value: 7.01e-10
                          10        20
                  ....*....|....*....|..
gi 1539159416  34 RKYDYVRRSIWHDTTTNTISVV 55
Cdd:pfam05385  87 RKYDYVRRSIWHDTTTNTISVV 108
Adeno_E4_ORF3 super family cl06131
Mastadenovirus E4 ORF3 protein; This family consists of several Mastadenovirus E4 ORF3 ...
2-37 4.50e-09

Mastadenovirus E4 ORF3 protein; This family consists of several Mastadenovirus E4 ORF3 proteins. Early proteins E4 ORF3 and E4 ORF6 have complementary functions during viral infection. Both proteins facilitate efficient viral DNA replication, late protein expression, and prevention of concatenation of viral genomes. A unique function of E4 ORF3 is the reorganization of nuclear structures known as PML oncogenic domains (PODs). The function of these domains is unclear, but PODs have been implicated in a number of important cellular processes, including transcriptional regulation, apoptosis, transformation, and response to interferon.


The actual alignment was detected with superfamily member pfam06931:

Pssm-ID: 462042  Cd Length: 112  Bit Score: 48.06  E-value: 4.50e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1539159416   2 IRCLRLKVEGALEQIFTMAGLNIRDLLRDILRRKYD 37
Cdd:pfam06931   1 IRCKREGAEEAIEQIAGLAGLDILDDILDILRDEND 36
 
Name Accession Description Interval E-value
Adeno_E4 pfam05385
Mastadenovirus early E4 13 kDa protein; This family consists of human and simian ...
34-55 7.01e-10

Mastadenovirus early E4 13 kDa protein; This family consists of human and simian mastadenovirus early E4 13 kDa proteins. Human adenovirus type 9 (Ad9) is unique in eliciting exclusively estrogen-dependent mammary tumours in rats and in not requiring viral E1 region transforming genes for tumorigenicity. E4 codes for an oncoprotein essential for tumourigenesis by Ad9.


Pssm-ID: 283128  Cd Length: 108  Bit Score: 50.07  E-value: 7.01e-10
                          10        20
                  ....*....|....*....|..
gi 1539159416  34 RKYDYVRRSIWHDTTTNTISVV 55
Cdd:pfam05385  87 RKYDYVRRSIWHDTTTNTISVV 108
Adeno_E4_ORF3 pfam06931
Mastadenovirus E4 ORF3 protein; This family consists of several Mastadenovirus E4 ORF3 ...
2-37 4.50e-09

Mastadenovirus E4 ORF3 protein; This family consists of several Mastadenovirus E4 ORF3 proteins. Early proteins E4 ORF3 and E4 ORF6 have complementary functions during viral infection. Both proteins facilitate efficient viral DNA replication, late protein expression, and prevention of concatenation of viral genomes. A unique function of E4 ORF3 is the reorganization of nuclear structures known as PML oncogenic domains (PODs). The function of these domains is unclear, but PODs have been implicated in a number of important cellular processes, including transcriptional regulation, apoptosis, transformation, and response to interferon.


Pssm-ID: 462042  Cd Length: 112  Bit Score: 48.06  E-value: 4.50e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1539159416   2 IRCLRLKVEGALEQIFTMAGLNIRDLLRDILRRKYD 37
Cdd:pfam06931   1 IRCKREGAEEAIEQIAGLAGLDILDDILDILRDEND 36
 
Name Accession Description Interval E-value
Adeno_E4 pfam05385
Mastadenovirus early E4 13 kDa protein; This family consists of human and simian ...
34-55 7.01e-10

Mastadenovirus early E4 13 kDa protein; This family consists of human and simian mastadenovirus early E4 13 kDa proteins. Human adenovirus type 9 (Ad9) is unique in eliciting exclusively estrogen-dependent mammary tumours in rats and in not requiring viral E1 region transforming genes for tumorigenicity. E4 codes for an oncoprotein essential for tumourigenesis by Ad9.


Pssm-ID: 283128  Cd Length: 108  Bit Score: 50.07  E-value: 7.01e-10
                          10        20
                  ....*....|....*....|..
gi 1539159416  34 RKYDYVRRSIWHDTTTNTISVV 55
Cdd:pfam05385  87 RKYDYVRRSIWHDTTTNTISVV 108
Adeno_E4_ORF3 pfam06931
Mastadenovirus E4 ORF3 protein; This family consists of several Mastadenovirus E4 ORF3 ...
2-37 4.50e-09

Mastadenovirus E4 ORF3 protein; This family consists of several Mastadenovirus E4 ORF3 proteins. Early proteins E4 ORF3 and E4 ORF6 have complementary functions during viral infection. Both proteins facilitate efficient viral DNA replication, late protein expression, and prevention of concatenation of viral genomes. A unique function of E4 ORF3 is the reorganization of nuclear structures known as PML oncogenic domains (PODs). The function of these domains is unclear, but PODs have been implicated in a number of important cellular processes, including transcriptional regulation, apoptosis, transformation, and response to interferon.


Pssm-ID: 462042  Cd Length: 112  Bit Score: 48.06  E-value: 4.50e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1539159416   2 IRCLRLKVEGALEQIFTMAGLNIRDLLRDILRRKYD 37
Cdd:pfam06931   1 IRCKREGAEEAIEQIAGLAGLDILDDILDILRDEND 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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