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Conserved domains on  [gi|1539159413|gb|AZP56026|]
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L5 pIV fiber protein [Vector AdCFP]

Protein Classification

Adeno_shaft and Adeno_knob domain-containing protein( domain architecture ID 12001795)

Adeno_shaft and Adeno_knob domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Adeno_knob super family cl08274
Adenoviral fibre protein (knob domain); Specific attachment of adenovirus is achieved through ...
 390-581 1.93e-91

Adenoviral fibre protein (knob domain); Specific attachment of adenovirus is achieved through interactions between host-cell receptors and the adenovirus fibre protein and is mediated by the globular carboxy-terminal domain of the adenovirus fibre protein, termed the carboxy-terminal knob domain.


The actual alignment was detected with superfamily member pfam00541:

Pssm-ID: 459847  Cd Length: 193  Bit Score: 279.40  E-value: 1.93e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539159413 390 TVGNKNNDKLTLWTTPAPSPNCRLNAEKDAKLTLVLTKCGSQILATVSVLAVKGSLAPISGTVQSAHLIIRFDENGVLLN 469
Cdd:pfam00541   1 TIGNKNDDKLTLWTTPDPSPNCRIHSDNDCKFTLVLTKCGSQVLATVAALAVSGDLSSMTGTVASVSIFLRFDQNGVLME 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539159413 470 NSFLDPEYWNFRNGDLTEGTAYTNAVGFMPNLSAYPKSHGKTAKSNIVSQVYLNGDKTKPVTLTITLNGTQETGDTTP-S 548
Cdd:pfam00541  81 NSSLKKHYWNFRNGNSTNANPYTNAVGFMPNLLAYPKTQSQTAKNNIVSQVYLHGDKTKPMILTITLNGTSESTETSEvS 160

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1539159413 549 AYSMSFSWDWSGHNYINEIFATSSYTFSYIAQE 581
Cdd:pfam00541 161 TYSMSFTWSWESGKYTTETFATNSYTFSYIAQE 193
Adeno_shaft pfam00608
Adenoviral fibre protein (repeat/shaft region); There is no separation between signal and ...
 34-77 8.20e-08

Adenoviral fibre protein (repeat/shaft region); There is no separation between signal and noise. Specific attachment of adenovirus is achieved through interactions between host-cell receptors and the adenovirus fibre protein and is mediated by the globular carboxy-terminal domain of the adenovirus fibre protein, rather than the 'shaft' region represented by this family. The alignment of this family contains two copies of a fifteen residue repeat found in the 'shaft' region of adenoviral fibre proteins.


:

Pssm-ID: 459865  Cd Length: 44  Bit Score: 48.47  E-value: 8.20e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1539159413  34 VSPNGFQESPPGVLSLRLSEPLVTSNGMLALKMGNGLSLDEAGN 77
Cdd:pfam00608   1 ISTNAPLKVNDSNLSLKTGPPLTVSNGALRLKLGAPLTVDSSGN 44
Adeno_shaft super family cl02909
Adenoviral fibre protein (repeat/shaft region); There is no separation between signal and ...
 205-250 3.59e-04

Adenoviral fibre protein (repeat/shaft region); There is no separation between signal and noise. Specific attachment of adenovirus is achieved through interactions between host-cell receptors and the adenovirus fibre protein and is mediated by the globular carboxy-terminal domain of the adenovirus fibre protein, rather than the 'shaft' region represented by this family. The alignment of this family contains two copies of a fifteen residue repeat found in the 'shaft' region of adenoviral fibre proteins.


The actual alignment was detected with superfamily member pfam00608:

Pssm-ID: 459865  Cd Length: 44  Bit Score: 38.45  E-value: 3.59e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1539159413 205 LKYGAPLHVTDdlNTLTVATGPGVTINNTSLQTKVTGALGFDSQGN 250
Cdd:pfam00608   1 ISTNAPLKVND--SNLSLKTGPPLTVSNGALRLKLGAPLTVDSSGN 44
Adeno_shaft super family cl02909
Adenoviral fibre protein (repeat/shaft region); There is no separation between signal and ...
 130-164 5.60e-04

Adenoviral fibre protein (repeat/shaft region); There is no separation between signal and noise. Specific attachment of adenovirus is achieved through interactions between host-cell receptors and the adenovirus fibre protein and is mediated by the globular carboxy-terminal domain of the adenovirus fibre protein, rather than the 'shaft' region represented by this family. The alignment of this family contains two copies of a fifteen residue repeat found in the 'shaft' region of adenoviral fibre proteins.


The actual alignment was detected with superfamily member pfam00608:

Pssm-ID: 459865  Cd Length: 44  Bit Score: 37.68  E-value: 5.60e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1539159413 130 QSQAPLTVHDSKLSIATQGPLTVSEGKLALQTSGP 164
Cdd:pfam00608   2 STNAPLKVNDSNLSLKTGPPLTVSNGALRLKLGAP 36
 
Name Accession Description Interval E-value
Adeno_knob pfam00541
Adenoviral fibre protein (knob domain); Specific attachment of adenovirus is achieved through ...
 390-581 1.93e-91

Adenoviral fibre protein (knob domain); Specific attachment of adenovirus is achieved through interactions between host-cell receptors and the adenovirus fibre protein and is mediated by the globular carboxy-terminal domain of the adenovirus fibre protein, termed the carboxy-terminal knob domain.


Pssm-ID: 459847  Cd Length: 193  Bit Score: 279.40  E-value: 1.93e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539159413 390 TVGNKNNDKLTLWTTPAPSPNCRLNAEKDAKLTLVLTKCGSQILATVSVLAVKGSLAPISGTVQSAHLIIRFDENGVLLN 469
Cdd:pfam00541   1 TIGNKNDDKLTLWTTPDPSPNCRIHSDNDCKFTLVLTKCGSQVLATVAALAVSGDLSSMTGTVASVSIFLRFDQNGVLME 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539159413 470 NSFLDPEYWNFRNGDLTEGTAYTNAVGFMPNLSAYPKSHGKTAKSNIVSQVYLNGDKTKPVTLTITLNGTQETGDTTP-S 548
Cdd:pfam00541  81 NSSLKKHYWNFRNGNSTNANPYTNAVGFMPNLLAYPKTQSQTAKNNIVSQVYLHGDKTKPMILTITLNGTSESTETSEvS 160

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1539159413 549 AYSMSFSWDWSGHNYINEIFATSSYTFSYIAQE 581
Cdd:pfam00541 161 TYSMSFTWSWESGKYTTETFATNSYTFSYIAQE 193
Adeno_shaft pfam00608
Adenoviral fibre protein (repeat/shaft region); There is no separation between signal and ...
 34-77 8.20e-08

Adenoviral fibre protein (repeat/shaft region); There is no separation between signal and noise. Specific attachment of adenovirus is achieved through interactions between host-cell receptors and the adenovirus fibre protein and is mediated by the globular carboxy-terminal domain of the adenovirus fibre protein, rather than the 'shaft' region represented by this family. The alignment of this family contains two copies of a fifteen residue repeat found in the 'shaft' region of adenoviral fibre proteins.


Pssm-ID: 459865  Cd Length: 44  Bit Score: 48.47  E-value: 8.20e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1539159413  34 VSPNGFQESPPGVLSLRLSEPLVTSNGMLALKMGNGLSLDEAGN 77
Cdd:pfam00608   1 ISTNAPLKVNDSNLSLKTGPPLTVSNGALRLKLGAPLTVDSSGN 44
Adeno_shaft pfam00608
Adenoviral fibre protein (repeat/shaft region); There is no separation between signal and ...
 205-250 3.59e-04

Adenoviral fibre protein (repeat/shaft region); There is no separation between signal and noise. Specific attachment of adenovirus is achieved through interactions between host-cell receptors and the adenovirus fibre protein and is mediated by the globular carboxy-terminal domain of the adenovirus fibre protein, rather than the 'shaft' region represented by this family. The alignment of this family contains two copies of a fifteen residue repeat found in the 'shaft' region of adenoviral fibre proteins.


Pssm-ID: 459865  Cd Length: 44  Bit Score: 38.45  E-value: 3.59e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1539159413 205 LKYGAPLHVTDdlNTLTVATGPGVTINNTSLQTKVTGALGFDSQGN 250
Cdd:pfam00608   1 ISTNAPLKVND--SNLSLKTGPPLTVSNGALRLKLGAPLTVDSSGN 44
Adeno_shaft pfam00608
Adenoviral fibre protein (repeat/shaft region); There is no separation between signal and ...
 130-164 5.60e-04

Adenoviral fibre protein (repeat/shaft region); There is no separation between signal and noise. Specific attachment of adenovirus is achieved through interactions between host-cell receptors and the adenovirus fibre protein and is mediated by the globular carboxy-terminal domain of the adenovirus fibre protein, rather than the 'shaft' region represented by this family. The alignment of this family contains two copies of a fifteen residue repeat found in the 'shaft' region of adenoviral fibre proteins.


Pssm-ID: 459865  Cd Length: 44  Bit Score: 37.68  E-value: 5.60e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1539159413 130 QSQAPLTVHDSKLSIATQGPLTVSEGKLALQTSGP 164
Cdd:pfam00608   2 STNAPLKVNDSNLSLKTGPPLTVSNGALRLKLGAP 36
 
Name Accession Description Interval E-value
Adeno_knob pfam00541
Adenoviral fibre protein (knob domain); Specific attachment of adenovirus is achieved through ...
 390-581 1.93e-91

Adenoviral fibre protein (knob domain); Specific attachment of adenovirus is achieved through interactions between host-cell receptors and the adenovirus fibre protein and is mediated by the globular carboxy-terminal domain of the adenovirus fibre protein, termed the carboxy-terminal knob domain.


Pssm-ID: 459847  Cd Length: 193  Bit Score: 279.40  E-value: 1.93e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539159413 390 TVGNKNNDKLTLWTTPAPSPNCRLNAEKDAKLTLVLTKCGSQILATVSVLAVKGSLAPISGTVQSAHLIIRFDENGVLLN 469
Cdd:pfam00541   1 TIGNKNDDKLTLWTTPDPSPNCRIHSDNDCKFTLVLTKCGSQVLATVAALAVSGDLSSMTGTVASVSIFLRFDQNGVLME 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539159413 470 NSFLDPEYWNFRNGDLTEGTAYTNAVGFMPNLSAYPKSHGKTAKSNIVSQVYLNGDKTKPVTLTITLNGTQETGDTTP-S 548
Cdd:pfam00541  81 NSSLKKHYWNFRNGNSTNANPYTNAVGFMPNLLAYPKTQSQTAKNNIVSQVYLHGDKTKPMILTITLNGTSESTETSEvS 160

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1539159413 549 AYSMSFSWDWSGHNYINEIFATSSYTFSYIAQE 581
Cdd:pfam00541 161 TYSMSFTWSWESGKYTTETFATNSYTFSYIAQE 193
Adeno_shaft pfam00608
Adenoviral fibre protein (repeat/shaft region); There is no separation between signal and ...
 34-77 8.20e-08

Adenoviral fibre protein (repeat/shaft region); There is no separation between signal and noise. Specific attachment of adenovirus is achieved through interactions between host-cell receptors and the adenovirus fibre protein and is mediated by the globular carboxy-terminal domain of the adenovirus fibre protein, rather than the 'shaft' region represented by this family. The alignment of this family contains two copies of a fifteen residue repeat found in the 'shaft' region of adenoviral fibre proteins.


Pssm-ID: 459865  Cd Length: 44  Bit Score: 48.47  E-value: 8.20e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1539159413  34 VSPNGFQESPPGVLSLRLSEPLVTSNGMLALKMGNGLSLDEAGN 77
Cdd:pfam00608   1 ISTNAPLKVNDSNLSLKTGPPLTVSNGALRLKLGAPLTVDSSGN 44
Adeno_shaft pfam00608
Adenoviral fibre protein (repeat/shaft region); There is no separation between signal and ...
 205-250 3.59e-04

Adenoviral fibre protein (repeat/shaft region); There is no separation between signal and noise. Specific attachment of adenovirus is achieved through interactions between host-cell receptors and the adenovirus fibre protein and is mediated by the globular carboxy-terminal domain of the adenovirus fibre protein, rather than the 'shaft' region represented by this family. The alignment of this family contains two copies of a fifteen residue repeat found in the 'shaft' region of adenoviral fibre proteins.


Pssm-ID: 459865  Cd Length: 44  Bit Score: 38.45  E-value: 3.59e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1539159413 205 LKYGAPLHVTDdlNTLTVATGPGVTINNTSLQTKVTGALGFDSQGN 250
Cdd:pfam00608   1 ISTNAPLKVND--SNLSLKTGPPLTVSNGALRLKLGAPLTVDSSGN 44
Adeno_shaft pfam00608
Adenoviral fibre protein (repeat/shaft region); There is no separation between signal and ...
 130-164 5.60e-04

Adenoviral fibre protein (repeat/shaft region); There is no separation between signal and noise. Specific attachment of adenovirus is achieved through interactions between host-cell receptors and the adenovirus fibre protein and is mediated by the globular carboxy-terminal domain of the adenovirus fibre protein, rather than the 'shaft' region represented by this family. The alignment of this family contains two copies of a fifteen residue repeat found in the 'shaft' region of adenoviral fibre proteins.


Pssm-ID: 459865  Cd Length: 44  Bit Score: 37.68  E-value: 5.60e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1539159413 130 QSQAPLTVHDSKLSIATQGPLTVSEGKLALQTSGP 164
Cdd:pfam00608   2 STNAPLKVNDSNLSLKTGPPLTVSNGALRLKLGAP 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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