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Conserved domains on  [gi|1538030741|ref|XP_027248149|]
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lysozyme C-1 [Cricetulus griseus]

Protein Classification

lysozyme family protein; lytic transglycosylase domain-containing protein( domain architecture ID 11261915)

lysozyme family protein; lytic transglycosylase domain-containing protein similar to lytic transglycosylase which catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LYZ1 smart00263
Alpha-lactalbumin / lysozyme C;
19-147 2.03e-85

Alpha-lactalbumin / lysozyme C;


:

Pssm-ID: 197612  Cd Length: 127  Bit Score: 245.66  E-value: 2.03e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538030741   19 KVYSRCEFARILKRHGMDGYRGISLANWVCLAQHESGFNTKATNYNPGpRSTDYGIFQINSKYWCNNGKTPGAVNACGIP 98
Cdd:smart00263   1 KVFTRCELARELKRLGLDGYRGISLANWVCLAFHESGYNTQATNYNNG-GSTDYGIFQINSKYWCNDGKTPGSVNACGIS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1538030741   99 CSVLLQDDITQAIKCAKRVVRDpQGIRAWVAWRSYCQNRNLSQYVRGCR 147
Cdd:smart00263  80 CSKLLDDDITDDVKCAKKIVSD-QGIDAWVAWKNHCQGEDLSQWIRGCG 127
 
Name Accession Description Interval E-value
LYZ1 smart00263
Alpha-lactalbumin / lysozyme C;
19-147 2.03e-85

Alpha-lactalbumin / lysozyme C;


Pssm-ID: 197612  Cd Length: 127  Bit Score: 245.66  E-value: 2.03e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538030741   19 KVYSRCEFARILKRHGMDGYRGISLANWVCLAQHESGFNTKATNYNPGpRSTDYGIFQINSKYWCNNGKTPGAVNACGIP 98
Cdd:smart00263   1 KVFTRCELARELKRLGLDGYRGISLANWVCLAFHESGYNTQATNYNNG-GSTDYGIFQINSKYWCNDGKTPGSVNACGIS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1538030741   99 CSVLLQDDITQAIKCAKRVVRDpQGIRAWVAWRSYCQNRNLSQYVRGCR 147
Cdd:smart00263  80 CSKLLDDDITDDVKCAKKIVSD-QGIDAWVAWKNHCQGEDLSQWIRGCG 127
LYZ_C cd16897
C-type lysozyme; C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase). ...
 19-146 2.71e-84

C-type lysozyme; C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase). In humans, lysozyme is found in a wide variety of tissue types and body fluids. It has bacteriolytic properties through the hydolysis of beta-1,4, glyocosidic linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan, as well as between N-acetyl-D-glucosamine residues in chitodextrins. This family also includes digestive stomach lysozyme, which allow ruminants to digest bacteria in the foregut. The mammalian enzyme is related to lysozyme found hen egg-whites and related species.


Pssm-ID: 340383  Cd Length: 126  Bit Score: 242.94  E-value: 2.71e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538030741  19 KVYSRCEFARILKRHGMDGYRGISLANWVCLAQHESGFNTKATNYNPGpRSTDYGIFQINSKYWCNNGKTPgAVNACGIP 98
Cdd:cd16897     1 KIFSRCELARILKRGGLDGYRGYSLANWVCLAYYESGFNTRATNENPD-GSTDYGIFQINSRYWCNDGKTP-SKNLCHIS 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1538030741  99 CSVLLQDDITQAIKCAKRVVRDPQGIRAWVAWRSYCQNRNLSQYVRGC 146
Cdd:cd16897    79 CSDLLNDDITDDIKCAKKIVKDPQGMGAWVAWRLHCEGRDLSRWLDGC 126
Lys pfam00062
C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of ...
 19-146 1.73e-72

C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bacterial cell walls. Structure is a multi-domain, mixed alpha and beta fold, containing four conserved disulfide bonds.


Pssm-ID: 395016  Cd Length: 123  Bit Score: 213.05  E-value: 1.73e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538030741  19 KVYSRCEFARILKRHGMDGYRGISLANWVCLAQHESGFNTKATNYNPGprSTDYGIFQINSKYWCNNGKTPGAVNACGIP 98
Cdd:pfam00062   1 KQFTRCELARELKKLGMDGYRGISLAEWVCLAFHESGYDTQAIVYNNG--STDYGIFQINDKYWCKDGKTPQSVNICGIS 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1538030741  99 CSVLLQDDITQAIKCAKRVVrDPQGIRAWVAWRSYCQnRNLSQYVrGC 146
Cdd:pfam00062  79 CDKLLDDDITDDIMCAKKIL-DPQGIDAWLAWKPHCS-EDLEQWI-GC 123
 
Name Accession Description Interval E-value
LYZ1 smart00263
Alpha-lactalbumin / lysozyme C;
19-147 2.03e-85

Alpha-lactalbumin / lysozyme C;


Pssm-ID: 197612  Cd Length: 127  Bit Score: 245.66  E-value: 2.03e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538030741   19 KVYSRCEFARILKRHGMDGYRGISLANWVCLAQHESGFNTKATNYNPGpRSTDYGIFQINSKYWCNNGKTPGAVNACGIP 98
Cdd:smart00263   1 KVFTRCELARELKRLGLDGYRGISLANWVCLAFHESGYNTQATNYNNG-GSTDYGIFQINSKYWCNDGKTPGSVNACGIS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1538030741   99 CSVLLQDDITQAIKCAKRVVRDpQGIRAWVAWRSYCQNRNLSQYVRGCR 147
Cdd:smart00263  80 CSKLLDDDITDDVKCAKKIVSD-QGIDAWVAWKNHCQGEDLSQWIRGCG 127
LYZ_C cd16897
C-type lysozyme; C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase). ...
 19-146 2.71e-84

C-type lysozyme; C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase). In humans, lysozyme is found in a wide variety of tissue types and body fluids. It has bacteriolytic properties through the hydolysis of beta-1,4, glyocosidic linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan, as well as between N-acetyl-D-glucosamine residues in chitodextrins. This family also includes digestive stomach lysozyme, which allow ruminants to digest bacteria in the foregut. The mammalian enzyme is related to lysozyme found hen egg-whites and related species.


Pssm-ID: 340383  Cd Length: 126  Bit Score: 242.94  E-value: 2.71e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538030741  19 KVYSRCEFARILKRHGMDGYRGISLANWVCLAQHESGFNTKATNYNPGpRSTDYGIFQINSKYWCNNGKTPgAVNACGIP 98
Cdd:cd16897     1 KIFSRCELARILKRGGLDGYRGYSLANWVCLAYYESGFNTRATNENPD-GSTDYGIFQINSRYWCNDGKTP-SKNLCHIS 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1538030741  99 CSVLLQDDITQAIKCAKRVVRDPQGIRAWVAWRSYCQNRNLSQYVRGC 146
Cdd:cd16897    79 CSDLLNDDITDDIKCAKKIVKDPQGMGAWVAWRLHCEGRDLSRWLDGC 126
Lys pfam00062
C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of ...
 19-146 1.73e-72

C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bacterial cell walls. Structure is a multi-domain, mixed alpha and beta fold, containing four conserved disulfide bonds.


Pssm-ID: 395016  Cd Length: 123  Bit Score: 213.05  E-value: 1.73e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538030741  19 KVYSRCEFARILKRHGMDGYRGISLANWVCLAQHESGFNTKATNYNPGprSTDYGIFQINSKYWCNNGKTPGAVNACGIP 98
Cdd:pfam00062   1 KQFTRCELARELKKLGMDGYRGISLAEWVCLAFHESGYDTQAIVYNNG--STDYGIFQINDKYWCKDGKTPQSVNICGIS 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1538030741  99 CSVLLQDDITQAIKCAKRVVrDPQGIRAWVAWRSYCQnRNLSQYVrGC 146
Cdd:pfam00062  79 CDKLLDDDITDDIMCAKKIL-DPQGIDAWLAWKPHCS-EDLEQWI-GC 123
LYZ cd00119
C-type lysozyme and alpha-lactalbumin; C-type lysozyme (chicken or conventional type, 1, ...
 19-143 7.60e-60

C-type lysozyme and alpha-lactalbumin; C-type lysozyme (chicken or conventional type, 1,4-beta-N-acetylmuramidase) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have primarily bacteriolytic function; hydrolysis of peptidoglycans of prokaryotic cell walls and transglycosylation. LA is a calcium-binding metalloprotein that is expressed exclusively in the mammary gland during lactation. LA is the regulatory subunit of the enzyme lactose synthase. The association of LA with the catalytic component of lactose synthase, galactosyltransferase, alters the acceptor substrate specificity of this glycosyltransferase, facilitating biosynthesis of lactose. Some lysozymes have evolved into digestive enzymes, both in mammals and invertebrates.


Pssm-ID: 340357  Cd Length: 122  Bit Score: 180.84  E-value: 7.60e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538030741  19 KVYSRCEFARILKRHGmdGYRGISLANWVCLAQHESGFNTKATNYNpGPRSTDYGIFQINSKYWCNNGKTPGAVNACGIP 98
Cdd:cd00119     1 KVFTRCELARLLKDIG--GYGGISLPNWVCLMKHESGYDTQATNEN-NNGSTDYGLFQINSRYWCKDGQTPGARNICDIS 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1538030741  99 CSVLLQDDITQAIKCAKRVVRDpQGIRAWVAWRSYCQNRnLSQYV 143
Cdd:cd00119    78 CSKLLTDDITDAIMCAKKIVDD-KGIDAWVAWKNHCQNK-LRQYV 120
LYZ_C_invert cd16899
C-type invertebrate lysozyme; C-type lysozyme proteins of invertebrates, including digestive ...
 19-144 7.56e-54

C-type invertebrate lysozyme; C-type lysozyme proteins of invertebrates, including digestive lysozymes 1 and 2 from Musca domestica, which aid in the use of bacteria as a food source. These lysozymes have high expression in the gut and optimal lytic activity at a lower pH. Other lysozymes in this subfamily have immunological roles. e.g. Anopheles gambiae has eight lysozymes, most of which seem to have immunological roles, those some may function as digestive enzymes in larvae. C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase) has bacteriolytic properties through the hydolysis of beta-1,4, glyocosidic linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan, as well as between N-acetyl-D-glucosamine residues in chitodextrins.


Pssm-ID: 381618 [Multi-domain]  Cd Length: 121  Bit Score: 165.48  E-value: 7.56e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538030741  19 KVYSRCEFARILKRHGMDgyRGiSLANWVCLAQHESGFNTKATNYNPGPRSTDYGIFQINSKYWCNNGKTPGavNACGIP 98
Cdd:cd16899     1 KIFTRCELARELRKLGVP--RS-QLANWVCLAEHESSFNTTAVGGPNSDGSGDYGLFQINDKYWCSPGGGSG--NGCNVK 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1538030741  99 CSVLLQDDITQAIKCAKRVVRDpQGIRAWVAWRSYCQNRNLSQYVR 144
Cdd:cd16899    76 CEDLLDDDISDDVKCAKKIYKE-QGFNAWVGWKNKCKGKNLPSYSD 120
LYZ_LA cd16898
alpha lactalbumin; alpha-lactalbumin (lactose synthase B protein, LA) is a calcium-binding ...
 21-142 8.83e-53

alpha lactalbumin; alpha-lactalbumin (lactose synthase B protein, LA) is a calcium-binding metalloprotein that is expressed exclusively in the mammary gland during lactation. LA is the regulatory subunit of the enzyme lactose synthase. The association of LA with the catalytic component of lactose synthase, galactosyltransferase, alters the acceptor substrate specificity of this glycosyltransferase, facilitating biosynthesis of lactose.


Pssm-ID: 340384  Cd Length: 123  Bit Score: 162.99  E-value: 8.83e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1538030741  21 YSRCEFARILKRHGMDGYRGISLANWVCLAQHESGFNTKATNYNPGprSTDYGIFQINSKYWCNNGKTPGAVNACGIPCS 100
Cdd:cd16898     3 FTKCELSQILKEHGLDGFNGISLPEWICVTFHTSGYDTQALVYNNG--STEYGLFQISNKGWCDDSQEPVSRNICGISCS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1538030741 101 VLLQDDITQAIKCAKRVVRDPQGIRAWVAWRSYCqNRNLSQY 142
Cdd:cd16898    81 KLLDDDITDDIACAKKILAIPKGIDYWKAHKPFC-REDLDQW 121
Lyz-like cd00442
lysozyme-like domains; This family contains several members, including soluble lytic ...
 45-116 6.05e-08

lysozyme-like domains; This family contains several members, including soluble lytic transglycosylases (SLT), goose egg-white lysozymes (GEWL), hen egg-white lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, chitosanases, and pesticin. Typical members are involved in the hydrolysis of beta-1,4- linked polysaccharides.


Pssm-ID: 381596 [Multi-domain]  Cd Length: 59  Bit Score: 46.63  E-value: 6.05e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1538030741  45 NWVCLAQHESGFNTkatNYNPGPRSTDYGIFQINSKYWCNNGKtpgavnacgipCSVLLQDDITQAIKCAKR 116
Cdd:cd00442     1 VLAAIIGQESGGNK---PANAGSGSGAAGLFQFMPGTWKAYGK-----------NSSSDLNDPEASIEAAAK 58
LT_IagB-like cd13400
Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like ...
 50-79 1.13e-04

Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381603 [Multi-domain]  Cd Length: 109  Bit Score: 39.05  E-value: 1.13e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 1538030741  50 AQHESGFNTKATNYNPGpRSTDYGIFQINS 79
Cdd:cd13400    12 AKVESGFNPNAINRNKN-GSYDIGLMQINS 40
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 49-79 6.56e-04

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 37.29  E-value: 6.56e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1538030741  49 LAQHESGFNTKATNynpgpRSTDYGIFQINS 79
Cdd:pfam01464  18 IAQQESGFNPKAVS-----KSGAVGLMQIMP 43
Phage_lysozyme2 pfam18013
Phage tail lysozyme; This domain has a lysozyme like fold. It is found in the tail protein of ...
 30-76 1.89e-03

Phage tail lysozyme; This domain has a lysozyme like fold. It is found in the tail protein of various phages probably giving them the ability to degrade the host cell wall peptidoglycan layer.


Pssm-ID: 465617  Cd Length: 139  Bit Score: 36.12  E-value: 1.89e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1538030741  30 LKRHGMDGYR--GIsLANWvclaQHESGFNTKATNYNPGPrSTDYGIFQ 76
Cdd:pfam18013  10 LKSKGYSKAAaaGI-LGNM----QRESGFNPGAVEDEGGG-GGGYGLVQ 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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