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Conserved domains on  [gi|1537994670|ref|XP_027261727|]
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cadherin-1 [Cricetulus griseus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 160-260 1.54e-40

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


:

Pssm-ID: 206635  Cd Length: 98  Bit Score: 144.02  E-value: 1.54e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537994670 160 IPPISCPENEKGPfpKNLVQIKSNRDKETTVFYSITGQGADRPPvGVFIIERESGWLKVTEPLDRENIAKYILYSHAVSS 239
Cdd:cd00031     1 IPDGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASL 77

                          90       100
                  ....*....|....*....|.
gi 1537994670 240 NGEAVEDPMEIVITVTDQNDN 260
Cdd:cd00031    78 GANVPQTSSVFSIEVYDENDN 98
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 29-118 1.22e-36

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


:

Pssm-ID: 462590  Cd Length: 90  Bit Score: 132.83  E-value: 1.22e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537994670  29 PCRPGFSAEVYTFQVPwRHLERGHLLGKVRFEGCTGRPRTAHFSEDSRFKVATDGTITLSRPLKLHKLQTSFLVHAWDST 108
Cdd:pfam08758   1 PCKPGFSEEVYTFSVP-RRLEEGQPLLNVKFNDCTGRKKTLYESSDPRFKVNTDGTVTAKRPVTLHGRQTSFLVHAWDSH 79

                          90
                  ....*....|.
gi 1537994670 109 HRK-FSTRVIL 118
Cdd:pfam08758  80 GEKmASVKVTV 90
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 268-373 4.68e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 111.25  E-value: 4.68e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537994670 268 VFHGNVLEGARPGTSVMQVSATDADDNENtynAAIAYTIISQDPElphkNMFTVNRDTGVISVvTSGLDRESYPTYTLVV 347
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGEN---GEVTYSIVSGNED----GLFSIDPSTGEITT-AKPLDREEQSSYTLTV 72

                          90       100
                  ....*....|....*....|....*.
gi 1537994670 348 QAADLQGEGLSTTATAVITVDDINDN 373
Cdd:cd11304    73 TATDGGGPPLSSTATVTITVLDVNDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 820-879 9.60e-26

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 100.69  E-value: 9.60e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537994670 820 ADSDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDQDQDYDYLNEWGNRFKKLADMYG 879
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 494-593 1.10e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 84.67  E-value: 1.10e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537994670 494 RVQVPEDFGVGQEIASYTAREPDIFMEQKITYRIWRDTA-NWLEINPETGAISTRAEMDREdtehvKNSTYTALIIATDD 572
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdGLFSIDPSTGEITTAKPLDRE-----EQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|.
gi 1537994670 573 GSPIATGTGTLLLVLFDINDN 593
Cdd:cd11304    78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 381-484 2.96e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.04  E-value: 2.96e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537994670 381 TYLGQVSENEA-NAYITTLKVTDNDLPhtPAWEAVYTIVNDPEQQFVIItDPTTndGTLKTTKGLDFEAKQQYILHVTVG 459
Cdd:cd11304     1 SYEVSVPENAPpGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI-DPST--GEITTAKPLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|....*.
gi 1537994670 460 NvvsfEGSPVPS-TATVTVDVLDVNE 484
Cdd:cd11304    76 D----GGGPPLSsTATVTITVLDVND 97
CA_like super family cl46864
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 600-688 6.37e-07

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


The actual alignment was detected with superfamily member pfam00028:

Pssm-ID: 481204 [Multi-domain]  Cd Length: 92  Bit Score: 48.07  E-value: 6.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537994670 600 RSMQFC---QRNPQPHVINILDPDLPPNTSPFTAELTHGASVNWTIkyndpAQESLILKPKKAL---ELGDYKINLKLMD 673
Cdd:pfam00028   1 YSASVPenaPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRI-----DPDTGDISTTKPLdreSIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 1537994670 674 NQK--KDQVTTLDIIVC 688
Cdd:pfam00028  76 SGGppLSSTATVTITVL 92
 
Name Accession Description Interval E-value
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 160-260 1.54e-40

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 144.02  E-value: 1.54e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537994670 160 IPPISCPENEKGPfpKNLVQIKSNRDKETTVFYSITGQGADRPPvGVFIIERESGWLKVTEPLDRENIAKYILYSHAVSS 239
Cdd:cd00031     1 IPDGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASL 77

                          90       100
                  ....*....|....*....|.
gi 1537994670 240 NGEAVEDPMEIVITVTDQNDN 260
Cdd:cd00031    78 GANVPQTSSVFSIEVYDENDN 98
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 29-118 1.22e-36

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 132.83  E-value: 1.22e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537994670  29 PCRPGFSAEVYTFQVPwRHLERGHLLGKVRFEGCTGRPRTAHFSEDSRFKVATDGTITLSRPLKLHKLQTSFLVHAWDST 108
Cdd:pfam08758   1 PCKPGFSEEVYTFSVP-RRLEEGQPLLNVKFNDCTGRKKTLYESSDPRFKVNTDGTVTAKRPVTLHGRQTSFLVHAWDSH 79

                          90
                  ....*....|.
gi 1537994670 109 HRK-FSTRVIL 118
Cdd:pfam08758  80 GEKmASVKVTV 90
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 30-116 4.04e-34

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 214999  Cd Length: 87  Bit Score: 125.47  E-value: 4.04e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537994670   30 CRPGFSAEVYTFQVPwRHLERGHLLGKVRFEGCTGRPRTAHFSEDSRFKVATDGTITLSRPLKLHKLQTSFLVHAWDS-T 108
Cdd:smart01055   1 CKPGFSEEKYTFHVP-SHLEAGQPLGRVNFEECLGSARLQFESSDPDFRVLEDGTVYATRPVSLSSEKKSFTVLAWDSqG 79


                   ....*...
gi 1537994670  109 HRKFSTRV 116
Cdd:smart01055  80 QEKKEIKV 87
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 268-373 4.68e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 111.25  E-value: 4.68e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537994670 268 VFHGNVLEGARPGTSVMQVSATDADDNENtynAAIAYTIISQDPElphkNMFTVNRDTGVISVvTSGLDRESYPTYTLVV 347
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGEN---GEVTYSIVSGNED----GLFSIDPSTGEITT-AKPLDREEQSSYTLTV 72

                          90       100
                  ....*....|....*....|....*.
gi 1537994670 348 QAADLQGEGLSTTATAVITVDDINDN 373
Cdd:cd11304    73 TATDGGGPPLSSTATVTITVLDVNDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 820-879 9.60e-26

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 100.69  E-value: 9.60e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537994670 820 ADSDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDQDQDYDYLNEWGNRFKKLADMYG 879
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin pfam00028
Cadherin domain;
269-367 4.00e-24

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 96.99  E-value: 4.00e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537994670 269 FHGNVLEGARPGTSVMQVSATDADDnenTYNAAIAYTIISQDPElphkNMFTVNRDTGVISVVTSgLDRESYPTYTLVVQ 348
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDL---GPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKP-LDRESIGEYELTVE 72

                          90
                  ....*....|....*....
gi 1537994670 349 AADLQGEGLSTTATAVITV 367
Cdd:pfam00028  73 ATDSGGPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 287-375 3.94e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.87  E-value: 3.94e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537994670  287 SATDADDNENtynAAIAYTIISQDPelphKNMFTVNRDTGVIsVVTSGLDRESYPTYTLVVQAADLQGEGLSTTATAVIT 366
Cdd:smart00112   1 SATDADSGEN---GKVTYSILSGND----DGLFSIDPETGEI-TTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTIT 72


                   ....*....
gi 1537994670  367 VDDINDNAP 375
Cdd:smart00112  73 VLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 494-593 1.10e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 84.67  E-value: 1.10e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537994670 494 RVQVPEDFGVGQEIASYTAREPDIFMEQKITYRIWRDTA-NWLEINPETGAISTRAEMDREdtehvKNSTYTALIIATDD 572
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdGLFSIDPSTGEITTAKPLDRE-----EQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|.
gi 1537994670 573 GSPIATGTGTLLLVLFDINDN 593
Cdd:cd11304    78 GGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
161-255 4.51e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.96  E-value: 4.51e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537994670 161 PPISCPENEK-GPFPKNLVQIKSNRDKETTVFYSITGQGADrppvGVFIIERESGWLKVTEPLDRENIAKYILYSHAVSS 239
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 1537994670 240 NGEAVEDPMEIVITVT 255
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 381-484 2.96e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.04  E-value: 2.96e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537994670 381 TYLGQVSENEA-NAYITTLKVTDNDLPhtPAWEAVYTIVNDPEQQFVIItDPTTndGTLKTTKGLDFEAKQQYILHVTVG 459
Cdd:cd11304     1 SYEVSVPENAPpGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI-DPST--GEITTAKPLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|....*.
gi 1537994670 460 NvvsfEGSPVPS-TATVTVDVLDVNE 484
Cdd:cd11304    76 D----GGGPPLSsTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 511-595 3.53e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 71.23  E-value: 3.53e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537994670  511 TAREPDIFMEQKITYRIWRDTA-NWLEINPETGAISTRAEMDREDTehvknSTYTALIIATDDGSPIATGTGTLLLVLFD 589
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDdGLFSIDPETGEITTTKPLDREEQ-----PEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 1537994670  590 INDNAP 595
Cdd:smart00112  76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 189-262 1.05e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.99  E-value: 1.05e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1537994670  189 TVFYSITGQGADrppvGVFIIERESGWLKVTEPLDRENIAKYILYSHAVSSNGEAVEDPMEIVITVTDQNDNRP 262
Cdd:smart00112  12 KVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
495-583 6.87e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.01  E-value: 6.87e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537994670 495 VQVPEDFGVGQEIASYTAREPDIFMEQKITYRIWRD-TANWLEINPETGAISTRAEMDREdtehvKNSTYTALIIATDDG 573
Cdd:pfam00028   3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRE-----SIGEYELTVEATDSG 77

                          90
                  ....*....|
gi 1537994670 574 SPIATGTGTL 583
Cdd:pfam00028  78 GPPLSSTATV 87
Cadherin pfam00028
Cadherin domain;
382-480 6.78e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 62.32  E-value: 6.78e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537994670 382 YLGQVSENEA-NAYITTLKVTDNDLPhtPAWEAVYTIVND-PEQQFVIitdpTTNDGTLKTTKGLDFEAKQQYILHVTVG 459
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLG--PNGRIFYSILGGgPGGNFRI----DPDTGDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|..
gi 1537994670 460 NvvsfEGSPVPS-TATVTVDVL 480
Cdd:pfam00028  75 D----SGGPPLSsTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 399-486 1.84e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.05  E-value: 1.84e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537994670  399 KVTDNDLPhtPAWEAVYTIVNDPEQQFVIItDPTTndGTLKTTKGLDFEAKQQYILHVTVgnvVSFEGSPVPSTATVTVD 478
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGNDDGLFSI-DPET--GEITTTKPLDREEQPEYTLTVEA---TDGGGPPLSSTATVTIT 72


                   ....*...
gi 1537994670  479 VLDVNEAP 486
Cdd:smart00112  73 VLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
600-688 6.37e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 48.07  E-value: 6.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537994670 600 RSMQFC---QRNPQPHVINILDPDLPPNTSPFTAELTHGASVNWTIkyndpAQESLILKPKKAL---ELGDYKINLKLMD 673
Cdd:pfam00028   1 YSASVPenaPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRI-----DPDTGDISTTKPLdreSIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 1537994670 674 NQK--KDQVTTLDIIVC 688
Cdd:pfam00028  76 SGGppLSSTATVTITVL 92
 
Name Accession Description Interval E-value
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 160-260 1.54e-40

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 144.02  E-value: 1.54e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537994670 160 IPPISCPENEKGPfpKNLVQIKSNRDKETTVFYSITGQGADRPPvGVFIIERESGWLKVTEPLDRENIAKYILYSHAVSS 239
Cdd:cd00031     1 IPDGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASL 77

                          90       100
                  ....*....|....*....|.
gi 1537994670 240 NGEAVEDPMEIVITVTDQNDN 260
Cdd:cd00031    78 GANVPQTSSVFSIEVYDENDN 98
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 29-118 1.22e-36

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 132.83  E-value: 1.22e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537994670  29 PCRPGFSAEVYTFQVPwRHLERGHLLGKVRFEGCTGRPRTAHFSEDSRFKVATDGTITLSRPLKLHKLQTSFLVHAWDST 108
Cdd:pfam08758   1 PCKPGFSEEVYTFSVP-RRLEEGQPLLNVKFNDCTGRKKTLYESSDPRFKVNTDGTVTAKRPVTLHGRQTSFLVHAWDSH 79

                          90
                  ....*....|.
gi 1537994670 109 HRK-FSTRVIL 118
Cdd:pfam08758  80 GEKmASVKVTV 90
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 30-116 4.04e-34

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 214999  Cd Length: 87  Bit Score: 125.47  E-value: 4.04e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537994670   30 CRPGFSAEVYTFQVPwRHLERGHLLGKVRFEGCTGRPRTAHFSEDSRFKVATDGTITLSRPLKLHKLQTSFLVHAWDS-T 108
Cdd:smart01055   1 CKPGFSEEKYTFHVP-SHLEAGQPLGRVNFEECLGSARLQFESSDPDFRVLEDGTVYATRPVSLSSEKKSFTVLAWDSqG 79


                   ....*...
gi 1537994670  109 HRKFSTRV 116
Cdd:smart01055  80 QEKKEIKV 87
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 268-373 4.68e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 111.25  E-value: 4.68e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537994670 268 VFHGNVLEGARPGTSVMQVSATDADDNENtynAAIAYTIISQDPElphkNMFTVNRDTGVISVvTSGLDRESYPTYTLVV 347
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGEN---GEVTYSIVSGNED----GLFSIDPSTGEITT-AKPLDREEQSSYTLTV 72

                          90       100
                  ....*....|....*....|....*.
gi 1537994670 348 QAADLQGEGLSTTATAVITVDDINDN 373
Cdd:cd11304    73 TATDGGGPPLSSTATVTITVLDVNDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 820-879 9.60e-26

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 100.69  E-value: 9.60e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537994670 820 ADSDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDQDQDYDYLNEWGNRFKKLADMYG 879
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin pfam00028
Cadherin domain;
269-367 4.00e-24

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 96.99  E-value: 4.00e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537994670 269 FHGNVLEGARPGTSVMQVSATDADDnenTYNAAIAYTIISQDPElphkNMFTVNRDTGVISVVTSgLDRESYPTYTLVVQ 348
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDL---GPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKP-LDRESIGEYELTVE 72

                          90
                  ....*....|....*....
gi 1537994670 349 AADLQGEGLSTTATAVITV 367
Cdd:pfam00028  73 ATDSGGPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 287-375 3.94e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.87  E-value: 3.94e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537994670  287 SATDADDNENtynAAIAYTIISQDPelphKNMFTVNRDTGVIsVVTSGLDRESYPTYTLVVQAADLQGEGLSTTATAVIT 366
Cdd:smart00112   1 SATDADSGEN---GKVTYSILSGND----DGLFSIDPETGEI-TTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTIT 72


                   ....*....
gi 1537994670  367 VDDINDNAP 375
Cdd:smart00112  73 VLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 494-593 1.10e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 84.67  E-value: 1.10e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537994670 494 RVQVPEDFGVGQEIASYTAREPDIFMEQKITYRIWRDTA-NWLEINPETGAISTRAEMDREdtehvKNSTYTALIIATDD 572
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdGLFSIDPSTGEITTAKPLDRE-----EQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|.
gi 1537994670 573 GSPIATGTGTLLLVLFDINDN 593
Cdd:cd11304    78 GGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
161-255 4.51e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.96  E-value: 4.51e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537994670 161 PPISCPENEK-GPFPKNLVQIKSNRDKETTVFYSITGQGADrppvGVFIIERESGWLKVTEPLDRENIAKYILYSHAVSS 239
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 1537994670 240 NGEAVEDPMEIVITVT 255
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 381-484 2.96e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.04  E-value: 2.96e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537994670 381 TYLGQVSENEA-NAYITTLKVTDNDLPhtPAWEAVYTIVNDPEQQFVIItDPTTndGTLKTTKGLDFEAKQQYILHVTVG 459
Cdd:cd11304     1 SYEVSVPENAPpGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI-DPST--GEITTAKPLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|....*.
gi 1537994670 460 NvvsfEGSPVPS-TATVTVDVLDVNE 484
Cdd:cd11304    76 D----GGGPPLSsTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 511-595 3.53e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 71.23  E-value: 3.53e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537994670  511 TAREPDIFMEQKITYRIWRDTA-NWLEINPETGAISTRAEMDREDTehvknSTYTALIIATDDGSPIATGTGTLLLVLFD 589
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDdGLFSIDPETGEITTTKPLDREEQ-----PEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 1537994670  590 INDNAP 595
Cdd:smart00112  76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 189-262 1.05e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.99  E-value: 1.05e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1537994670  189 TVFYSITGQGADrppvGVFIIERESGWLKVTEPLDRENIAKYILYSHAVSSNGEAVEDPMEIVITVTDQNDNRP 262
Cdd:smart00112  12 KVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 163-260 2.05e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 66.95  E-value: 2.05e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537994670 163 ISCPENEKGPFPknLVQIK-SNRDKET--TVFYSITGQGADrppvGVFIIERESGWLKVTEPLDRENIAKYILYSHAVSS 239
Cdd:cd11304     4 VSVPENAPPGTV--VLTVSaTDPDSGEngEVTYSIVSGNED----GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|.
gi 1537994670 240 NGEAVEDPMEIVITVTDQNDN 260
Cdd:cd11304    78 GGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
495-583 6.87e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.01  E-value: 6.87e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537994670 495 VQVPEDFGVGQEIASYTAREPDIFMEQKITYRIWRD-TANWLEINPETGAISTRAEMDREdtehvKNSTYTALIIATDDG 573
Cdd:pfam00028   3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRE-----SIGEYELTVEATDSG 77

                          90
                  ....*....|
gi 1537994670 574 SPIATGTGTL 583
Cdd:pfam00028  78 GPPLSSTATV 87
Cadherin pfam00028
Cadherin domain;
382-480 6.78e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 62.32  E-value: 6.78e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537994670 382 YLGQVSENEA-NAYITTLKVTDNDLPhtPAWEAVYTIVND-PEQQFVIitdpTTNDGTLKTTKGLDFEAKQQYILHVTVG 459
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLG--PNGRIFYSILGGgPGGNFRI----DPDTGDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|..
gi 1537994670 460 NvvsfEGSPVPS-TATVTVDVL 480
Cdd:pfam00028  75 D----SGGPPLSsTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 399-486 1.84e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.05  E-value: 1.84e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537994670  399 KVTDNDLPhtPAWEAVYTIVNDPEQQFVIItDPTTndGTLKTTKGLDFEAKQQYILHVTVgnvVSFEGSPVPSTATVTVD 478
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGNDDGLFSI-DPET--GEITTTKPLDREEQPEYTLTVEA---TDGGGPPLSSTATVTIT 72


                   ....*...
gi 1537994670  479 VLDVNEAP 486
Cdd:smart00112  73 VLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
600-688 6.37e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 48.07  E-value: 6.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1537994670 600 RSMQFC---QRNPQPHVINILDPDLPPNTSPFTAELTHGASVNWTIkyndpAQESLILKPKKAL---ELGDYKINLKLMD 673
Cdd:pfam00028   1 YSASVPenaPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRI-----DPDTGDISTTKPLdreSIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 1537994670 674 NQK--KDQVTTLDIIVC 688
Cdd:pfam00028  76 SGGppLSSTATVTITVL 92
Cadherin_3 pfam16184
Cadherin-like;
358-421 5.79e-03

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 37.58  E-value: 5.79e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1537994670 358 STTATAVITVDDINDNAPVFNPTTYLgQVSENEANAyITT--LKVTDNDlphTPAWEAVYTIVNDP 421
Cdd:pfam16184   2 SVPFTFNITIIPVNDEAPVLTTNTGL-RLWEGSSRP-ITPdlLQAEDPD---TPPEDLTYTVVQGP 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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