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zinc-dependent transcriptional regulator AdcR [Streptococcus mitis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AdcR_fam_Zn_TF NF038251
zinc-dependent MarR family transcriptional regulator; This HMM represents one of several ...
 4-145 1.51e-74

zinc-dependent MarR family transcriptional regulator; This HMM represents one of several unusual clades within the MarR family transcription factors that bind Zn(2+) and regulate the response to zinc abundance or scarcity. Members include AdcR (adhesin competence regulator), which regulates expression of the high affinity zinc uptake transporter AdcABC and various other proteins.


:

Pssm-ID: 439551  Cd Length: 143  Bit Score: 218.69  E-value: 1.51e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1535705868   4 LAQEIDTFLNEVILQAENQHEILIGHCTSEVALTNTQEHILMLLSEESLTNSELARRLNVSQAAVTKAIKSLVKEGMLET 83
Cdd:NF038251    2 LAQQIDQFLNQILLKAENQHELLIGKCQSDVKLTNTQEHILMLLSEERLTNSDLAKKLNVSQAAVTKAVKSLVKQGMLES 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1535705868  84 SKDPKDARVIFYQLTDLARPIAEEHHHHHEHTLLTYEEVATQFTPNEQKVIQRFLTALVGEI 145
Cdd:NF038251   82 VKDKKDARVTYYSLTELAKPIAEEHEHHHQHTLSVYDELLDQFSDEEQEVISRFLDALSEEL 143
 
Name Accession Description Interval E-value
AdcR_fam_Zn_TF NF038251
zinc-dependent MarR family transcriptional regulator; This HMM represents one of several ...
 4-145 1.51e-74

zinc-dependent MarR family transcriptional regulator; This HMM represents one of several unusual clades within the MarR family transcription factors that bind Zn(2+) and regulate the response to zinc abundance or scarcity. Members include AdcR (adhesin competence regulator), which regulates expression of the high affinity zinc uptake transporter AdcABC and various other proteins.


Pssm-ID: 439551  Cd Length: 143  Bit Score: 218.69  E-value: 1.51e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1535705868   4 LAQEIDTFLNEVILQAENQHEILIGHCTSEVALTNTQEHILMLLSEESLTNSELARRLNVSQAAVTKAIKSLVKEGMLET 83
Cdd:NF038251    2 LAQQIDQFLNQILLKAENQHELLIGKCQSDVKLTNTQEHILMLLSEERLTNSDLAKKLNVSQAAVTKAVKSLVKQGMLES 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1535705868  84 SKDPKDARVIFYQLTDLARPIAEEHHHHHEHTLLTYEEVATQFTPNEQKVIQRFLTALVGEI 145
Cdd:NF038251   82 VKDKKDARVTYYSLTELAKPIAEEHEHHHQHTLSVYDELLDQFSDEEQEVISRFLDALSEEL 143
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
1-141 1.79e-16

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 70.77  E-value: 1.79e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1535705868   1 MRHLAQEIDTFLNEVILQAENQHEILIGHCTSEVALTNTQEHILMLLSE-ESLTNSELARRLNVSQAAVTKAIKSLVKEG 79
Cdd:COG1846     1 MSDEPDPAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEaGGLTQSELAERLGLTKSTVSRLLDRLEEKG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1535705868  80 MLETSKDPKDARVIFYQLTDLARPIAEEHHHHHEHTLltyEEVATQFTPNEQKVIQRFLTAL 141
Cdd:COG1846    81 LVEREPDPEDRRAVLVRLTEKGRALLEEARPALEALL---AELLAGLSEEELEALLRLLRRL 139
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
36-131 2.48e-15

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 66.85  E-value: 2.48e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1535705868   36 LTNTQEHILMLLSE-ESLTNSELARRLNVSQAAVTKAIKSLVKEGMLETSKDPKDARVIFYQLTDLARPIAEEHHHHHEH 114
Cdd:smart00347   8 LTPTQFLVLRILYEeGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLEARSE 87

                           90
                   ....*....|....*..
gi 1535705868  115 tllTYEEVATQFTPNEQ 131
Cdd:smart00347  88 ---TLAELLAGLTAEEQ 101
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 36-93 6.50e-13

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 59.48  E-value: 6.50e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1535705868  36 LTNTQEHILMLLSE-ESLTNSELARRLNVSQAAVTKAIKSLVKEGMLETSKDPKDARVI 93
Cdd:pfam01047   1 LTLTQFHILRILYEhGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 43-102 4.60e-11

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 55.38  E-value: 4.60e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1535705868  43 ILMLLSEESLTNSELARRLNVSQAAVTKAIKSLVKEGMLETSKDPkdaRVIFYQLTDLAR 102
Cdd:cd00090    12 ILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREG---RRVYYSLTDAER 68
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 43-99 1.40e-06

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 43.60  E-value: 1.40e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1535705868  43 ILMLLSEESLTNSELARRLNVSQAAVTKAIKSLVKEGMLETSkdpKDARVIFYQLTD 99
Cdd:NF033788   16 ILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSR---REGRWVYYRLAD 69
PRK09775 PRK09775
type II toxin-antitoxin system HipA family toxin YjjJ;
43-105 6.98e-04

type II toxin-antitoxin system HipA family toxin YjjJ;


Pssm-ID: 236623 [Multi-domain]  Cd Length: 442  Bit Score: 38.41  E-value: 6.98e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1535705868  43 ILMLLSEESLTNSELARRLNVSQAAVTKAIKSL----VKEGmletskdpkDARVIFYQLTDLARPIA 105
Cdd:PRK09775    5 LTTLLLQGPLSAAELAARLGVSQATLSRLLAALgdqvVRFG---------KARATRYALLRPLRGVS 62
 
Name Accession Description Interval E-value
AdcR_fam_Zn_TF NF038251
zinc-dependent MarR family transcriptional regulator; This HMM represents one of several ...
 4-145 1.51e-74

zinc-dependent MarR family transcriptional regulator; This HMM represents one of several unusual clades within the MarR family transcription factors that bind Zn(2+) and regulate the response to zinc abundance or scarcity. Members include AdcR (adhesin competence regulator), which regulates expression of the high affinity zinc uptake transporter AdcABC and various other proteins.


Pssm-ID: 439551  Cd Length: 143  Bit Score: 218.69  E-value: 1.51e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1535705868   4 LAQEIDTFLNEVILQAENQHEILIGHCTSEVALTNTQEHILMLLSEESLTNSELARRLNVSQAAVTKAIKSLVKEGMLET 83
Cdd:NF038251    2 LAQQIDQFLNQILLKAENQHELLIGKCQSDVKLTNTQEHILMLLSEERLTNSDLAKKLNVSQAAVTKAVKSLVKQGMLES 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1535705868  84 SKDPKDARVIFYQLTDLARPIAEEHHHHHEHTLLTYEEVATQFTPNEQKVIQRFLTALVGEI 145
Cdd:NF038251   82 VKDKKDARVTYYSLTELAKPIAEEHEHHHQHTLSVYDELLDQFSDEEQEVISRFLDALSEEL 143
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
1-141 1.79e-16

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 70.77  E-value: 1.79e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1535705868   1 MRHLAQEIDTFLNEVILQAENQHEILIGHCTSEVALTNTQEHILMLLSE-ESLTNSELARRLNVSQAAVTKAIKSLVKEG 79
Cdd:COG1846     1 MSDEPDPAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEaGGLTQSELAERLGLTKSTVSRLLDRLEEKG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1535705868  80 MLETSKDPKDARVIFYQLTDLARPIAEEHHHHHEHTLltyEEVATQFTPNEQKVIQRFLTAL 141
Cdd:COG1846    81 LVEREPDPEDRRAVLVRLTEKGRALLEEARPALEALL---AELLAGLSEEELEALLRLLRRL 139
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
36-131 2.48e-15

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 66.85  E-value: 2.48e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1535705868   36 LTNTQEHILMLLSE-ESLTNSELARRLNVSQAAVTKAIKSLVKEGMLETSKDPKDARVIFYQLTDLARPIAEEHHHHHEH 114
Cdd:smart00347   8 LTPTQFLVLRILYEeGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLEARSE 87

                           90
                   ....*....|....*..
gi 1535705868  115 tllTYEEVATQFTPNEQ 131
Cdd:smart00347  88 ---TLAELLAGLTAEEQ 101
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 36-93 6.50e-13

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 59.48  E-value: 6.50e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1535705868  36 LTNTQEHILMLLSE-ESLTNSELARRLNVSQAAVTKAIKSLVKEGMLETSKDPKDARVI 93
Cdd:pfam01047   1 LTLTQFHILRILYEhGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 43-102 4.60e-11

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 55.38  E-value: 4.60e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1535705868  43 ILMLLSEESLTNSELARRLNVSQAAVTKAIKSLVKEGMLETSKDPkdaRVIFYQLTDLAR 102
Cdd:cd00090    12 ILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREG---RRVYYSLTDAER 68
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
43-99 8.70e-11

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 54.14  E-value: 8.70e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1535705868   43 ILMLLSEESLTNSELARRLNVSQAAVTKAIKSLVKEGMLETSKDPkdaRVIFYQLTD 99
Cdd:smart00418   2 ILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREG---KRVYYSLTD 55
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 36-91 3.43e-09

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 49.89  E-value: 3.43e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1535705868  36 LTNTQEHILM-LLSEESLTNSELARRLNVSQAAVTKAIKSLVKEGMLETSKDPKDAR 91
Cdd:pfam12802   3 LTPAQFRVLLaLARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRR 59
HTH_27 pfam13463
Winged helix DNA-binding domain;
31-99 7.21e-09

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 49.21  E-value: 7.21e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1535705868  31 TSEVALTNtqeHILMLLSEESLtnSELARRLNVSQAAVTKAIKSLVKEGMLETSKDPKDARVIFYQLTD 99
Cdd:pfam13463   3 RLEALILH---NIGHRGDPKTL--ADICFRLNVEDSHVSYSLKKLTEAGLVEREGSEEDGRETRVRLTA 66
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
43-99 3.87e-08

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 47.96  E-value: 3.87e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1535705868  43 ILMLLSEESLTNSELARRLNVSQAAVTKAIKSLVKEGMLETSkdpKDARVIFYQLTD 99
Cdd:COG0640    25 ILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSR---REGRWVYYRLAD 78
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
36-105 1.79e-07

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 47.12  E-value: 1.79e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1535705868  36 LTNTQEHILM---LLSEE--SLTNSELARRLNVSQAAVTKAIKSLVKEGMLETSKDpkdaRVIFyqLTDLARPIA 105
Cdd:COG1321     4 LSESEEDYLKaiyELSEEggPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPY----GGIT--LTEEGRELA 72
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 43-99 1.40e-06

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 43.60  E-value: 1.40e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1535705868  43 ILMLLSEESLTNSELARRLNVSQAAVTKAIKSLVKEGMLETSkdpKDARVIFYQLTD 99
Cdd:NF033788   16 ILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSR---REGRWVYYRLAD 69
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
43-105 1.84e-05

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 42.96  E-value: 1.84e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1535705868  43 ILMLLSEESLTNSELARRLNVSQAAVTKAIKSLVKEGMLETSKDpkdarviFYQLTDLARPIA 105
Cdd:COG4742    21 ILLLLAEGPKTRSELAESLDVSRSTILRQLKELEERGLIERDDG-------EYELTTLGRLVV 76
GbsR COG1510
DNA-binding transcriptional regulator GbsR, MarR family [Transcription];
42-99 3.28e-05

DNA-binding transcriptional regulator GbsR, MarR family [Transcription];


Pssm-ID: 441119  Cd Length: 164  Bit Score: 41.46  E-value: 3.28e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1535705868  42 HILMLLSEESLTNSELARRLNVSQAAVTKAIKSLVKEGMLETSKDPKDaRVIFYQLTD 99
Cdd:COG1510    33 YALLYLSDEPLTADELAEELGVSKSSVSTALRELEDWGLVRRVRKPGD-RKDYFRAEK 89
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
39-81 3.62e-05

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 38.95  E-value: 3.62e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1535705868  39 TQEHILMLLSEES-LTNSELARRLNVSQAAVTKAIKSLVKEGML 81
Cdd:pfam13412   2 TDRKILNLLQENPrISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 43-81 5.81e-05

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 38.19  E-value: 5.81e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1535705868  43 ILMLLSEESLTNSELARRLNVSQAAVTKAIKSLVKEGML 81
Cdd:pfam01022   7 ILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
34-82 6.06e-05

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 40.15  E-value: 6.06e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1535705868  34 VALTNTQEHILMLLSEES-LTNSELARRLNVSQAAVTKAIKSLVKEGMLE 82
Cdd:COG1522     1 MELDEIDRRILRLLQEDGrLSFAELAERVGLSESTVLRRVRRLEEAGVIR 50
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
39-103 9.06e-05

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 40.68  E-value: 9.06e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1535705868  39 TQEHILMLLSEE-SLTNSELARRLNVSQAAVTKAIKSLVKEGMLEtSKDPKDAR---VIFYQLTDLARP 103
Cdd:COG2345    14 TRRRILELLKRAgPVTAAELAEALGLTPNAVRRHLDALEEEGLVE-RETERRGRgrpAKLYRLTEAGRA 81
TrmB pfam01978
Sugar-specific transcriptional regulator TrmB; One member of this family, TrmB, has been shown ...
 46-88 1.18e-04

Sugar-specific transcriptional regulator TrmB; One member of this family, TrmB, has been shown to be a sugar-specific transcriptional regulator of the trehalose/maltose ABC transporter in Thermococcus litoralis.


Pssm-ID: 396525 [Multi-domain]  Cd Length: 67  Bit Score: 38.27  E-value: 1.18e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1535705868  46 LLSEESLTNSELARRLNVSQAAVTKAIKSLVKEGMLETSKDPK 88
Cdd:pfam01978  17 LLKLGPATADEIAEESGVPRSKVYEVLRSLEDKGLVEREKGRP 59
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 42-82 1.20e-04

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 39.04  E-value: 1.20e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1535705868   42 HILMLLSEES-LTNSELARRLNVSQAAVTKAIKSLVKEGMLE 82
Cdd:smart00344   7 KILEELQKDArISLAELAKKVGLSPSTVHNRVKRLEEEGVIK 48
Fe_dep_repress pfam01325
Iron dependent repressor, N-terminal DNA binding domain; This family includes the Diphtheria ...
 41-86 3.68e-04

Iron dependent repressor, N-terminal DNA binding domain; This family includes the Diphtheria toxin repressor. DNA binding is through a helix-turn-helix motif.


Pssm-ID: 396062 [Multi-domain]  Cd Length: 57  Bit Score: 36.58  E-value: 3.68e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1535705868  41 EHILMLLSEES-LTNSELARRLNVSQAAVTKAIKSLVKEGMLETSKD 86
Cdd:pfam01325   8 ETIYTLSEEKGvVKTKDLAERLNVSPSTVSEMLKKLEKMGYVDYEPY 54
BirA COG1654
Biotin operon repressor [Transcription];
36-79 4.55e-04

Biotin operon repressor [Transcription];


Pssm-ID: 441260 [Multi-domain]  Cd Length: 324  Bit Score: 38.81  E-value: 4.55e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1535705868  36 LTNTQEHILMLLS-EESLTNSELARRLNVSQAAVTKAIKSLVKEG 79
Cdd:COG1654     2 MSSTRLKLLRLLAdGEFHSGEELAEELGVSRAAVWKHIKALRELG 46
PRK09775 PRK09775
type II toxin-antitoxin system HipA family toxin YjjJ;
43-105 6.98e-04

type II toxin-antitoxin system HipA family toxin YjjJ;


Pssm-ID: 236623 [Multi-domain]  Cd Length: 442  Bit Score: 38.41  E-value: 6.98e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1535705868  43 ILMLLSEESLTNSELARRLNVSQAAVTKAIKSL----VKEGmletskdpkDARVIFYQLTDLARPIA 105
Cdd:PRK09775    5 LTTLLLQGPLSAAELAARLGVSQATLSRLLAALgdqvVRFG---------KARATRYALLRPLRGVS 62
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 56-83 9.26e-04

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 35.50  E-value: 9.26e-04
                          10        20
                  ....*....|....*....|....*...
gi 1535705868  56 ELARRLNVSQAAVTKAIKSLVKEGMLET 83
Cdd:cd07377    30 ELAEELGVSRTTVREALRELEAEGLVER 57
HTH_DTXR smart00529
Helix-turn-helix diphteria tox regulatory element; iron dependent repressor
 54-105 1.20e-03

Helix-turn-helix diphteria tox regulatory element; iron dependent repressor


Pssm-ID: 197774 [Multi-domain]  Cd Length: 95  Bit Score: 36.04  E-value: 1.20e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1535705868   54 NSELARRLNVSQAAVTKAIKSLVKEGMLETSKDpkdarvIFYQLTDLARPIA 105
Cdd:smart00529   1 TSEIAERLNVSPPTVTEMLKKLEKMGLVEYEPY------RGITLTEKGRRLA 46
IclR COG1414
DNA-binding transcriptional regulator, IclR family [Transcription];
43-98 1.42e-03

DNA-binding transcriptional regulator, IclR family [Transcription];


Pssm-ID: 441024 [Multi-domain]  Cd Length: 253  Bit Score: 37.49  E-value: 1.42e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1535705868  43 ILMLLSE--ESLTNSELARRLNVSQAAVTKAIKSLVKEGMLEtsKDPKDARvifYQLT 98
Cdd:COG1414    14 ILEALAEagGGLSLSELARRLGLPKSTVHRLLATLEEEGYVE--RDPEGGR---YRLG 66
RPA_C pfam08784
Replication protein A C terminal; This domain corresponds to the C terminal of the single ...
 35-86 1.81e-03

Replication protein A C terminal; This domain corresponds to the C terminal of the single stranded DNA binding protein RPA (replication protein A). RPA is involved in many DNA metabolic pathways including DNA replication, DNA repair, recombination, cell cycle and DNA damage checkpoints.


Pssm-ID: 400920  Cd Length: 106  Bit Score: 35.82  E-value: 1.81e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1535705868  35 ALTNTQEHILMLL-----SEESLTNSELARRLNVSQAAVTKAIKSLVKEGMLETSKD 86
Cdd:pfam08784  48 GLTPLQDQVLNLIkqppnGNEGVHVDEIAQRLGLPVNDVKQAVDFLSNEGHIYSTID 104
HTH_11 pfam08279
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.
 41-80 2.36e-03

HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.


Pssm-ID: 429896 [Multi-domain]  Cd Length: 52  Bit Score: 34.33  E-value: 2.36e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1535705868  41 EHILMLL--SEESLTNSELARRLNVSQAAVTKAIKSLVKEGM 80
Cdd:pfam08279   1 LQILQLLleARGPISGQELAEKLGVSRRTIRRDIKILEELGV 42
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
56-82 3.89e-03

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 35.99  E-value: 3.89e-03
                          10        20
                  ....*....|....*....|....*..
gi 1535705868  56 ELARRLNVSQAAVTKAIKSLVKEGMLE 82
Cdd:COG2188    34 ELAEEFGVSRMTVRKALDELVEEGLLE 60
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 46-88 5.66e-03

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 33.28  E-value: 5.66e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1535705868  46 LLSEESLTNSELARRLNVSQAAVTKAIKSLVKEGMLETSKDPK 88
Cdd:pfam12840  19 LVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
12-124 9.36e-03

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 34.49  E-value: 9.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1535705868  12 LNEVILQAENQHEILIGHCTSEVALTNTQEHILM-LLSEESLTNSELARRLNVSQAAVTKAIKSLVKEGMLETSKDPKDA 90
Cdd:PRK11512   14 LGRLIHMVNQKKDRLLNEYLSPLDITAAQFKVLCsIRCAACITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDK 93

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1535705868  91 RVIFYQLTDLARPIAEEHHHHHEHTL-------LTYEEVAT 124
Cdd:PRK11512   94 RGVLVKLTTSGAAICEQCHQLVGQDLhqeltknLTADEVAT 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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