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Conserved domains on  [gi|1528894928|emb|VDK46610|]
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unnamed protein product [Anisakis simplex]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DHD_Dac cd21081
Dachshund-homology domain found in the retinal determination protein Dachshund and similar ...
 31-135 4.57e-63

Dachshund-homology domain found in the retinal determination protein Dachshund and similar proteins; Dachshund proteins act as transcription factors involved in the regulation of organogenesis. They may be a regulator of SIX1, SIX6 and probably SIX5. The Dachshund-homology domain (DHD), also known as the N-terminal Ski/Sno/Dac domain, adopts a mixed alpha/beta structure containing a helix-turn-helix motif, similar to features found in the forkhead/winged-helix family of DNA binding proteins. It contains a conserved CLPQ motif and can bind co-factors. Its structure suggests that it may also bind DNA. It has been postulated that Dachshund proteins may bind to chromatin DNA via their DHD domains.


:

Pssm-ID: 410784  Cd Length: 95  Bit Score: 191.42  E-value: 4.57e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1528894928  31 QTVKLYEYRGKRVAGFEVFGRQMICLPQLYEIFLKNLVGGLHTVYTKLKRLEIRPVVCSVEQrkihanptemVRALRSLG 110
Cdd:cd21081     1 NECKMVEYRGAKVAAFTVDGEELICLPQAFELFLKHLVGGLHTVYTKLKRLDITPVVCNVEQ----------VRILRGLG 70

                          90       100
                  ....*....|....*....|....*
gi 1528894928 111 AIQPGVNRCKLISSADFDRLYGDCH 135
Cdd:cd21081    71 AIQPGVNRCKLISRKDFDTLYNDCT 95
 
Name Accession Description Interval E-value
DHD_Dac cd21081
Dachshund-homology domain found in the retinal determination protein Dachshund and similar ...
 31-135 4.57e-63

Dachshund-homology domain found in the retinal determination protein Dachshund and similar proteins; Dachshund proteins act as transcription factors involved in the regulation of organogenesis. They may be a regulator of SIX1, SIX6 and probably SIX5. The Dachshund-homology domain (DHD), also known as the N-terminal Ski/Sno/Dac domain, adopts a mixed alpha/beta structure containing a helix-turn-helix motif, similar to features found in the forkhead/winged-helix family of DNA binding proteins. It contains a conserved CLPQ motif and can bind co-factors. Its structure suggests that it may also bind DNA. It has been postulated that Dachshund proteins may bind to chromatin DNA via their DHD domains.


Pssm-ID: 410784  Cd Length: 95  Bit Score: 191.42  E-value: 4.57e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1528894928  31 QTVKLYEYRGKRVAGFEVFGRQMICLPQLYEIFLKNLVGGLHTVYTKLKRLEIRPVVCSVEQrkihanptemVRALRSLG 110
Cdd:cd21081     1 NECKMVEYRGAKVAAFTVDGEELICLPQAFELFLKHLVGGLHTVYTKLKRLDITPVVCNVEQ----------VRILRGLG 70

                          90       100
                  ....*....|....*....|....*
gi 1528894928 111 AIQPGVNRCKLISSADFDRLYGDCH 135
Cdd:cd21081    71 AIQPGVNRCKLISRKDFDTLYNDCT 95
Ski_Sno pfam02437
SKI/SNO/DAC family; This family contains a presumed domain that is about 100 amino acids long. ...
 33-134 1.97e-27

SKI/SNO/DAC family; This family contains a presumed domain that is about 100 amino acids long. All members of this family contain a conserved CLPQ motif. The c-ski proto-oncogene has been shown to influence proliferation, morphological transformation and myogenic differentiation. Sno, a Ski proto-oncogene homolog, is expressed in two isoforms and plays a role in the response to proliferation stimuli. Dachshund also contains this domain. It is involved in various aspects of development.


Pssm-ID: 460558  Cd Length: 100  Bit Score: 100.81  E-value: 1.97e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1528894928  33 VKLYEYRGKRVAGFEVFGRQMICLPQLYEIFLKNLvgGLHTVYTKLKRLEIRPVVCSVEQRKIhanptemvraLRSLGAI 112
Cdd:pfam02437   9 RMETMLEGEVISCFMVGGEERLCLPQILNTLLKDF--SLTQINTVCDELIITCVRCTPEQLEI----------LKLLGIL 76

                          90       100
                  ....*....|....*....|..
gi 1528894928 113 QPGVNRCKLISSADFDRLYGDC 134
Cdd:pfam02437  77 PPSVRRCGLITKTDAERLCDAL 98
 
Name Accession Description Interval E-value
DHD_Dac cd21081
Dachshund-homology domain found in the retinal determination protein Dachshund and similar ...
 31-135 4.57e-63

Dachshund-homology domain found in the retinal determination protein Dachshund and similar proteins; Dachshund proteins act as transcription factors involved in the regulation of organogenesis. They may be a regulator of SIX1, SIX6 and probably SIX5. The Dachshund-homology domain (DHD), also known as the N-terminal Ski/Sno/Dac domain, adopts a mixed alpha/beta structure containing a helix-turn-helix motif, similar to features found in the forkhead/winged-helix family of DNA binding proteins. It contains a conserved CLPQ motif and can bind co-factors. Its structure suggests that it may also bind DNA. It has been postulated that Dachshund proteins may bind to chromatin DNA via their DHD domains.


Pssm-ID: 410784  Cd Length: 95  Bit Score: 191.42  E-value: 4.57e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1528894928  31 QTVKLYEYRGKRVAGFEVFGRQMICLPQLYEIFLKNLVGGLHTVYTKLKRLEIRPVVCSVEQrkihanptemVRALRSLG 110
Cdd:cd21081     1 NECKMVEYRGAKVAAFTVDGEELICLPQAFELFLKHLVGGLHTVYTKLKRLDITPVVCNVEQ----------VRILRGLG 70

                          90       100
                  ....*....|....*....|....*
gi 1528894928 111 AIQPGVNRCKLISSADFDRLYGDCH 135
Cdd:cd21081    71 AIQPGVNRCKLISRKDFDTLYNDCT 95
Ski_Sno pfam02437
SKI/SNO/DAC family; This family contains a presumed domain that is about 100 amino acids long. ...
 33-134 1.97e-27

SKI/SNO/DAC family; This family contains a presumed domain that is about 100 amino acids long. All members of this family contain a conserved CLPQ motif. The c-ski proto-oncogene has been shown to influence proliferation, morphological transformation and myogenic differentiation. Sno, a Ski proto-oncogene homolog, is expressed in two isoforms and plays a role in the response to proliferation stimuli. Dachshund also contains this domain. It is involved in various aspects of development.


Pssm-ID: 460558  Cd Length: 100  Bit Score: 100.81  E-value: 1.97e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1528894928  33 VKLYEYRGKRVAGFEVFGRQMICLPQLYEIFLKNLvgGLHTVYTKLKRLEIRPVVCSVEQRKIhanptemvraLRSLGAI 112
Cdd:pfam02437   9 RMETMLEGEVISCFMVGGEERLCLPQILNTLLKDF--SLTQINTVCDELIITCVRCTPEQLEI----------LKLLGIL 76

                          90       100
                  ....*....|....*....|..
gi 1528894928 113 QPGVNRCKLISSADFDRLYGDC 134
Cdd:pfam02437  77 PPSVRRCGLITKTDAERLCDAL 98
DHD_Ski_Sno_Dac cd21074
Dachshund-homology domain found in the Ski/Sno/Dac family of transcriptional regulators; The ...
 33-131 3.17e-21

Dachshund-homology domain found in the Ski/Sno/Dac family of transcriptional regulators; The Dachshund-homology domain (DHD), also known as the N-terminal Ski/Sno/Dac domain, adopts a mixed alpha/beta structure containing a helix-turn-helix motif, similar to features found in the forkhead/winged-helix family of DNA binding proteins. It contains a conserved CLPQ motif and can bind co-factors. Its structure suggests that it may also bind DNA. Members of this family include the Ski protein, Ski-like protein (Sno), and Dachshund proteins. Ski may play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. It functions as a repressor of transforming growth factor-beta (TGF-beta) signaling. Ski-like protein, also known as SKIL or Sno, is the ski proto-oncogene homolog. It may have regulatory roles in cell division or differentiation in response to extracellular signals. Dachshund proteins are essential components of a regulatory network controlling cell fate determination. They have been implicated in eye, limb, brain, and muscle development.


Pssm-ID: 410781  Cd Length: 88  Bit Score: 84.27  E-value: 3.17e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1528894928  33 VKLYEYRGKRVAGFEVFGRQMICLPQLYEIFLKNLVggLHTVYTKLKRLEIRPVVCSVEQRKIhanptemvraLRSLGAI 112
Cdd:cd21074     1 LVTSTLEGKRIAGFEIDGEERLCLPQILNLVLKDFV--QTQIHNRCTKLKIICTRCDQEQLKI----------LKRLGIL 68

                          90
                  ....*....|....*....
gi 1528894928 113 QPGVNRCKLISSADFDRLY 131
Cdd:cd21074    69 PPKAKSCGLISKSDAERLL 87
DHD_SKIDA1 cd21082
Dachshund-homology domain found in SKI/DACH domain-containing protein 1 (SKIDA1) and similar ...
 37-134 5.55e-08

Dachshund-homology domain found in SKI/DACH domain-containing protein 1 (SKIDA1) and similar proteins; SKIDA1 is also known as protein DLN-1. Its biological function remains unclear. The Dachshund-homology domain (DHD), also known as the N-terminal Ski/Sno/Dac domain, adopts a mixed alpha/beta structure containing a helix-turn-helix motif, similar to features found in the forkhead/winged-helix family of DNA binding proteins. It contains a conserved CLPQ motif and can bind co-factors. Its structure suggests that it may also bind DNA.


Pssm-ID: 410785  Cd Length: 91  Bit Score: 49.26  E-value: 5.55e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1528894928  37 EYRGKRVAGFEVFGRQMICLPQLYEIFLKNLVGGlhTVYTKLKRLEIrpvvcsveqrKIHANPTEMVRALRSLGAIQPGV 116
Cdd:cd21082     5 EVHGVELGYLYINGKQMFALSQVFTDLLPNTPRT--TVHKRMDRLKV----------KKHHCDLEELRKLKALNGIAFHA 72

                          90
                  ....*....|....*...
gi 1528894928 117 NRCKLISSADFDRLYGDC 134
Cdd:cd21082    73 AKCTLISREDVERLYSSY 90
DHD_Sno cd21084
Dachshund-homology domain found in Ski-like protein (Sno) and similar proteins; Ski-like ...
 26-130 3.35e-04

Dachshund-homology domain found in Ski-like protein (Sno) and similar proteins; Ski-like protein, also known as SKIL, Ski-related oncogene (Sno), or Ski-related protein, is the ski proto-oncogene homolog. It may have regulatory roles in cell division or differentiation in response to extracellular signals. The Dachshund-homology domain (DHD), also known as the N-terminal Ski/Sno/Dac domain, adopts a mixed alpha/beta structure containing a helix-turn-helix motif, similar to features found in the forkhead/winged-helix family of DNA binding proteins. It contains a conserved CLPQ motif and can bind co-factors. Its structure suggests that it may also bind DNA.


Pssm-ID: 410787  Cd Length: 100  Bit Score: 38.79  E-value: 3.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1528894928  26 DSTEAQTVKLYEyrGKRVAGFEVFGRQMICLPQLYEIFLKNLvgGLHTVYTKLKRLEIRPVVCSVEQRKIhanptemvra 105
Cdd:cd21084     3 DSSTELTQTVLE--GESISCFMVGGEKRLCLPQVLNSVLRDF--SLQQINTVCDELYIYCSRCTSDQLHI---------- 68

                          90       100
                  ....*....|....*....|....*
gi 1528894928 106 LRSLGAIQPGVNRCKLISSADFDRL 130
Cdd:cd21084    69 LKVLGILPFNAPSCGLITLTDAQRL 93
DHD_Ski_Sno cd21079
Dachshund-homology domain found in Ski, Ski-like protein (Sno), and similar proteins; Ski may ...
 40-132 3.78e-04

Dachshund-homology domain found in Ski, Ski-like protein (Sno), and similar proteins; Ski may play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. It functions as a repressor of transforming growth factor-beta (TGF-beta) signaling. Ski-like protein, also known as SKIL or Sno, is the ski proto-oncogene homolog. It may have regulatory roles in cell division or differentiation in response to extracellular signals. The Dachshund-homology domain (DHD), also known as the N-terminal Ski/Sno/Dac domain, adopts a mixed alpha/beta structure containing a helix-turn-helix motif, similar to features found in the forkhead/winged-helix family of DNA binding proteins. It contains a conserved CLPQ motif and can bind co-factors. Its structure suggests that it may also bind DNA.


Pssm-ID: 410782  Cd Length: 91  Bit Score: 38.31  E-value: 3.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1528894928  40 GKRVAGFEVFGRQMICLPQLYEIFLKNLvgGLHTVYTKLKRLEIRPVVCSVEQRKIhanptemvraLRSLGAIQPGVNRC 119
Cdd:cd21079     8 GETIACFVVGGEKRLCLPQILNTVLRDF--SLQQINRVCDDLHIYCSRCTPEQLET----------LKLAGILPPSAPSC 75

                          90
                  ....*....|...
gi 1528894928 120 KLISSADFDRLYG 132
Cdd:cd21079    76 GLITKTDAERLCS 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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