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Conserved domains on  [gi|1525534318|gb|RQV28601|]
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4-carboxymuconolactone decarboxylase [Burkholderia cenocepacia]

Protein Classification

carboxymuconolactone decarboxylase family protein( domain architecture ID 571)

carboxymuconolactone decarboxylase family protein, similar to Enterobacter hormaechei YciW

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ahpD_dom super family cl00460
alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region ...
 3-124 2.81e-39

alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region of homology among a family of mostly uncharacterized proteins of 110 to 227 amino acids. Most members of this family contain the motif EXXXXXX[SA]XXXXXC[VIL]XCXXXH. Members of the family include the alkylhydroperoxidase AhpD of Mycobacterium tuberculosis, a macrophage infectivity potentiator peptide of Legionella pneumophila, and an uncharacterized peptide in the tetrachloroethene reductive dehalogenase operon of Dehalospirillum multivorans. We suggest that many peptides containing this domain may have alkylhydroperoxidase or related antioxidant activity. [Unknown function, General]


The actual alignment was detected with superfamily member TIGR02425:

Pssm-ID: 469777  Cd Length: 123  Bit Score: 128.33  E-value: 2.81e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525534318   3 EQDR-EYGKARRIDVMGEAFVERAMRDLDGFSRPLQNWLNEHAWGSTWQRGGIDLKTRSLCTCAMLAALGRGTELKGHVR 81
Cdd:TIGR02425   1 EQERyEQGMQVRRAVLGDAHVDRALAATTDFDQPFQELITEYAWGTVWTRPGLTKRERSLVTIALLAALGRDEELAMHVR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1525534318  82 GALNNGASLVEIREVLLHSALYAGAPAAVEAFRNAREVLSDLG 124
Cdd:TIGR02425  81 ATANTGVTEDDIKEVLLHVAIYAGVPAANHAFALAKEALAEMA 123
 
Name Accession Description Interval E-value
decarb_PcaC TIGR02425
4-carboxymuconolactone decarboxylase; Members of this family are 4-carboxymuconolactone ...
 3-124 2.81e-39

4-carboxymuconolactone decarboxylase; Members of this family are 4-carboxymuconolactone decarboxylase, which catalyzes the third step in the catabolism of protocatechuate (and therefore the fourth step in the catabolism of para-hydroxybenzoate, of 3-hydroxybenzoate, of vanillate, etc.). Most members of this family are encoded within protocatechuate catabolism operons. This protein is sometimes found as a fusion protein with other enzymes of the pathway, as in Rhodococcus opacus, Streptomyces avermitilis, and Caulobacter crescentus. [Energy metabolism, Other]


Pssm-ID: 131478  Cd Length: 123  Bit Score: 128.33  E-value: 2.81e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525534318   3 EQDR-EYGKARRIDVMGEAFVERAMRDLDGFSRPLQNWLNEHAWGSTWQRGGIDLKTRSLCTCAMLAALGRGTELKGHVR 81
Cdd:TIGR02425   1 EQERyEQGMQVRRAVLGDAHVDRALAATTDFDQPFQELITEYAWGTVWTRPGLTKRERSLVTIALLAALGRDEELAMHVR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1525534318  82 GALNNGASLVEIREVLLHSALYAGAPAAVEAFRNAREVLSDLG 124
Cdd:TIGR02425  81 ATANTGVTEDDIKEVLLHVAIYAGVPAANHAFALAKEALAEMA 123
YurZ COG0599
Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone ...
 19-124 8.15e-34

Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family [General function prediction only];


Pssm-ID: 440364  Cd Length: 114  Bit Score: 113.89  E-value: 8.15e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525534318  19 EAFVERAMRDLDGFSRPLQNWLnEHAWGSTWQRGGIDLKTRSLCTCAMLAALGRGTELKGHVRGALNNGASLVEIREVLL 98
Cdd:COG0599     8 EEYVPRALEALAEFAPEFAEAF-EALFGDVWARGALDPKTRELITLAALAALGCEPCLKAHVRAALNAGATREEIAEALL 86

                          90       100
                  ....*....|....*....|....*.
gi 1525534318  99 HSALYAGAPAAVEAFRNAREVLSDLG 124
Cdd:COG0599    87 VAAVYAGFPAALNALRAALEVLEELG 112
CMD pfam02627
Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1. ...
 36-118 2.29e-17

Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.


Pssm-ID: 460628 [Multi-domain]  Cd Length: 84  Bit Score: 71.19  E-value: 2.29e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525534318  36 LQNWLNEHAWGSTWQrGGIDLKTRSLCTCAMLAALGRGTELKGHVRGALNNGASLVEIREVLLHSALYAGAPAAVEAFRN 115
Cdd:pfam02627   3 LLAALTALAFGLLWD-GGLDPKTRELIALAVSAANGCAYCLDAHTRAALKAGVTEEEIAEVLAWAAAYAGGPAARAALAA 81


                  ...
gi 1525534318 116 ARE 118
Cdd:pfam02627  82 AEE 84
 
Name Accession Description Interval E-value
decarb_PcaC TIGR02425
4-carboxymuconolactone decarboxylase; Members of this family are 4-carboxymuconolactone ...
 3-124 2.81e-39

4-carboxymuconolactone decarboxylase; Members of this family are 4-carboxymuconolactone decarboxylase, which catalyzes the third step in the catabolism of protocatechuate (and therefore the fourth step in the catabolism of para-hydroxybenzoate, of 3-hydroxybenzoate, of vanillate, etc.). Most members of this family are encoded within protocatechuate catabolism operons. This protein is sometimes found as a fusion protein with other enzymes of the pathway, as in Rhodococcus opacus, Streptomyces avermitilis, and Caulobacter crescentus. [Energy metabolism, Other]


Pssm-ID: 131478  Cd Length: 123  Bit Score: 128.33  E-value: 2.81e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525534318   3 EQDR-EYGKARRIDVMGEAFVERAMRDLDGFSRPLQNWLNEHAWGSTWQRGGIDLKTRSLCTCAMLAALGRGTELKGHVR 81
Cdd:TIGR02425   1 EQERyEQGMQVRRAVLGDAHVDRALAATTDFDQPFQELITEYAWGTVWTRPGLTKRERSLVTIALLAALGRDEELAMHVR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1525534318  82 GALNNGASLVEIREVLLHSALYAGAPAAVEAFRNAREVLSDLG 124
Cdd:TIGR02425  81 ATANTGVTEDDIKEVLLHVAIYAGVPAANHAFALAKEALAEMA 123
YurZ COG0599
Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone ...
 19-124 8.15e-34

Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family [General function prediction only];


Pssm-ID: 440364  Cd Length: 114  Bit Score: 113.89  E-value: 8.15e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525534318  19 EAFVERAMRDLDGFSRPLQNWLnEHAWGSTWQRGGIDLKTRSLCTCAMLAALGRGTELKGHVRGALNNGASLVEIREVLL 98
Cdd:COG0599     8 EEYVPRALEALAEFAPEFAEAF-EALFGDVWARGALDPKTRELITLAALAALGCEPCLKAHVRAALNAGATREEIAEALL 86

                          90       100
                  ....*....|....*....|....*.
gi 1525534318  99 HSALYAGAPAAVEAFRNAREVLSDLG 124
Cdd:COG0599    87 VAAVYAGFPAALNALRAALEVLEELG 112
CMD pfam02627
Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1. ...
 36-118 2.29e-17

Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.


Pssm-ID: 460628 [Multi-domain]  Cd Length: 84  Bit Score: 71.19  E-value: 2.29e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525534318  36 LQNWLNEHAWGSTWQrGGIDLKTRSLCTCAMLAALGRGTELKGHVRGALNNGASLVEIREVLLHSALYAGAPAAVEAFRN 115
Cdd:pfam02627   3 LLAALTALAFGLLWD-GGLDPKTRELIALAVSAANGCAYCLDAHTRAALKAGVTEEEIAEVLAWAAAYAGGPAARAALAA 81


                  ...
gi 1525534318 116 ARE 118
Cdd:pfam02627  82 AEE 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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