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Conserved domains on  [gi|1524746632|gb|AZF91788|]
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cro-like repressor [Streptococcus phage CHPC1067]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 366238)

helix-turn-helix (HTH) domain-containing protein with an XRE (Xenobiotic Response Element) family; HTH domain binds DNA and may function as a transcriptional regulator

Gene Ontology:  GO:0003677|GO:0006355

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_XRE super family cl22854
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 1-68 3.47e-20

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


The actual alignment was detected with superfamily member pfam05339:

Pssm-ID: 473980  Cd Length: 68  Bit Score: 75.26  E-value: 3.47e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1524746632  1 MEFKYDKLKGRIKEKYGTQENFAKAIGKTQTTTSFKINGKRLWNQEEIIKAIELLDLSKDDIVEYFFN 68
Cdd:pfam05339  1 MSYDYSSLLGKITEKYGTQYNFAIAMGLSERSLSLKLNDKVTWKDDEILKAVHLLDLNPQKIPKYFFN 68
 
Name Accession Description Interval E-value
DUF739 pfam05339
Protein of unknown function (DUF739); This family contains several bacteriophage proteins. ...
 1-68 3.47e-20

Protein of unknown function (DUF739); This family contains several bacteriophage proteins. Some of the proteins in this family have been labeled putative cro repressor proteins.


Pssm-ID: 428429  Cd Length: 68  Bit Score: 75.26  E-value: 3.47e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1524746632  1 MEFKYDKLKGRIKEKYGTQENFAKAIGKTQTTTSFKINGKRLWNQEEIIKAIELLDLSKDDIVEYFFN 68
Cdd:pfam05339  1 MSYDYSSLLGKITEKYGTQYNFAIAMGLSERSLSLKLNDKVTWKDDEILKAVHLLDLNPQKIPKYFFN 68
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 6-62 4.48e-04

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 34.45  E-value: 4.48e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 1524746632  6 DKLKGRIKEKYGTQENFAKAIGKTQTTTSFKINGKRLWNQEEIIKAIELLDLSKDDI 62
Cdd:cd00093    2 ERLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
7-65 3.28e-03

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 32.13  E-value: 3.28e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1524746632  7 KLKGRIKE---KYG-TQENFAKAIGKTQTTTSFKINGKRLWNQEEIIKAIELLDLSKDDIVEY 65
Cdd:COG1476    4 KLGNRLKElrkERGlTQEELAELLGVSRQTISAIENGKYNPSLELALKIARALGVSLEELFSL 66
 
Name Accession Description Interval E-value
DUF739 pfam05339
Protein of unknown function (DUF739); This family contains several bacteriophage proteins. ...
 1-68 3.47e-20

Protein of unknown function (DUF739); This family contains several bacteriophage proteins. Some of the proteins in this family have been labeled putative cro repressor proteins.


Pssm-ID: 428429  Cd Length: 68  Bit Score: 75.26  E-value: 3.47e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1524746632  1 MEFKYDKLKGRIKEKYGTQENFAKAIGKTQTTTSFKINGKRLWNQEEIIKAIELLDLSKDDIVEYFFN 68
Cdd:pfam05339  1 MSYDYSSLLGKITEKYGTQYNFAIAMGLSERSLSLKLNDKVTWKDDEILKAVHLLDLNPQKIPKYFFN 68
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 6-62 4.48e-04

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 34.45  E-value: 4.48e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 1524746632  6 DKLKGRIKEKYGTQENFAKAIGKTQTTTSFKINGKRLWNQEEIIKAIELLDLSKDDI 62
Cdd:cd00093    2 ERLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
7-65 3.28e-03

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 32.13  E-value: 3.28e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1524746632  7 KLKGRIKE---KYG-TQENFAKAIGKTQTTTSFKINGKRLWNQEEIIKAIELLDLSKDDIVEY 65
Cdd:COG1476    4 KLGNRLKElrkERGlTQEELAELLGVSRQTISAIENGKYNPSLELALKIARALGVSLEELFSL 66
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 8-62 3.31e-03

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 32.13  E-value: 3.31e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 1524746632  8 LKGRIKEKYGTQENFAKAIGKTQTTTSFKINGKRLWNQEEIIKAIELLDLSKDDI 62
Cdd:pfam01381  1 LKELREELGLSQEELAEKLGVSRSTISKIENGKREPSLETLKKLAEALGVSLDEL 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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