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Conserved domains on  [gi|15242153|ref|NP_197608|]
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Leucine-rich repeat (LRR) family protein [Arabidopsis thaliana]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 10549656)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN00113 super family cl33413
leucine-rich repeat receptor-like protein kinase; Provisional
 75-185 2.82e-26

leucine-rich repeat receptor-like protein kinase; Provisional


The actual alignment was detected with superfamily member PLN00113:

Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 106.09  E-value: 2.82e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242153   75 VDLGNSNLSGHLAPELGKLEHLQYLELYKNNIQGTIPSELGNLKNLISLDLYNNNLTGIVPTSLGKLKSLVFLRLNDNRL 154
Cdd:PLN00113 241 LDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNF 320

                         90       100       110
                 ....*....|....*....|....*....|.
gi 15242153  155 TGPIPRALTAIPSLKVVDVSSNDLCGTIPTN 185
Cdd:PLN00113 321 TGKIPVALTSLPRLQVLQLWSNKFSGEIPKN 351
LRRNT_2 pfam08263
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 27-67 1.33e-11

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


:

Pssm-ID: 462411 [Multi-domain]  Cd Length: 41  Bit Score: 57.30  E-value: 1.33e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 15242153    27 ANSEGDALYALRRSLTDPDHVLQSWDPTLVNPCTWFHVTCN 67
Cdd:pfam08263   1 LNDDGQALLAFKSSLNDPPGALSSWNSSSSDPCSWTGVTCD 41
 
Name Accession Description Interval E-value
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 75-185 2.82e-26

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 106.09  E-value: 2.82e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242153   75 VDLGNSNLSGHLAPELGKLEHLQYLELYKNNIQGTIPSELGNLKNLISLDLYNNNLTGIVPTSLGKLKSLVFLRLNDNRL 154
Cdd:PLN00113 241 LDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNF 320

                         90       100       110
                 ....*....|....*....|....*....|.
gi 15242153  155 TGPIPRALTAIPSLKVVDVSSNDLCGTIPTN 185
Cdd:PLN00113 321 TGKIPVALTSLPRLQVLQLWSNKFSGEIPKN 351
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
73-178 2.41e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.90  E-value: 2.41e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242153  73 TRVDLGNSNLSgHLAPELGKLEHLQYLELYKNNIQgTIPSELGNLKNLISLDLYNNNLTGIvPTSLGKLKSLVFLRLNDN 152
Cdd:COG4886 116 ESLDLSGNQLT-DLPEELANLTNLKELDLSNNQLT-DLPEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNN 192

                        90       100
                ....*....|....*....|....*.
gi 15242153 153 RLTgPIPRALTAIPSLKVVDVSSNDL 178
Cdd:COG4886 193 QIT-DLPEPLGNLTNLEELDLSGNQL 217
LRRNT_2 pfam08263
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 27-67 1.33e-11

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 462411 [Multi-domain]  Cd Length: 41  Bit Score: 57.30  E-value: 1.33e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 15242153    27 ANSEGDALYALRRSLTDPDHVLQSWDPTLVNPCTWFHVTCN 67
Cdd:pfam08263   1 LNDDGQALLAFKSSLNDPPGALSSWNSSSSDPCSWTGVTCD 41
LRR_8 pfam13855
Leucine rich repeat;
95-154 4.46e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 4.46e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242153    95 HLQYLELYKNNIQGTIPSELGNLKNLISLDLYNNNLTGIVPTSLGKLKSLVFLRLNDNRL 154
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 71-176 6.55e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.47  E-value: 6.55e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242153  71 RVTRVDLGNSNLSghlapELGKLEH---LQYLELYKNNIQgTIPSeLGNLKNLISLDLYNNNLTGI-------------- 133
Cdd:cd21340   3 RITHLYLNDKNIT-----KIDNLSLcknLKVLYLYDNKIT-KIEN-LEFLTNLTHLYLQNNQIEKIenlenlvnlkklyl 75

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15242153 134 ------VPTSLGKLKSLVFLRLNDNRLTGPI-----PRALTAI-PSLKVVDVSSN 176
Cdd:cd21340  76 ggnrisVVEGLENLTNLEELHIENQRLPPGEkltfdPRSLAALsNSLRVLNISGN 130
 
Name Accession Description Interval E-value
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 75-185 2.82e-26

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 106.09  E-value: 2.82e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242153   75 VDLGNSNLSGHLAPELGKLEHLQYLELYKNNIQGTIPSELGNLKNLISLDLYNNNLTGIVPTSLGKLKSLVFLRLNDNRL 154
Cdd:PLN00113 241 LDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNF 320

                         90       100       110
                 ....*....|....*....|....*....|.
gi 15242153  155 TGPIPRALTAIPSLKVVDVSSNDLCGTIPTN 185
Cdd:PLN00113 321 TGKIPVALTSLPRLQVLQLWSNKFSGEIPKN 351
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 30-183 1.50e-25

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 103.77  E-value: 1.50e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242153   30 EGDALYALRRSLTDPDHVLQSWDPTlVNPCTWFHVTCNQDNRVTRVDLGNSNLSGHLAPELGKLEHLQ------------ 97
Cdd:PLN00113  30 ELELLLSFKSSINDPLKYLSNWNSS-ADVCLWQGITCNNSSRVVSIDLSGKNISGKISSAIFRLPYIQtinlsnnqlsgp 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242153   98 -------------YLELYKNNIQGTIPSelGNLKNLISLDLYNNNLTGIVPTSLGKLKSLVFLRLNDNRLTGPIPRALTA 164
Cdd:PLN00113 109 ipddifttssslrYLNLSNNNFTGSIPR--GSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTN 186

                        170
                 ....*....|....*....
gi 15242153  165 IPSLKVVDVSSNDLCGTIP 183
Cdd:PLN00113 187 LTSLEFLTLASNQLVGQIP 205
PLN03150 PLN03150
hypothetical protein; Provisional
 33-193 1.29e-23

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 97.96  E-value: 1.29e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242153   33 ALYALRRSLTDPDHVLQSWDPTLVNPCTWFHVTCNQDNRVTR-----VDLGNSNLSGHLAPELGKLEHLQYLELYKNNIQ 107
Cdd:PLN03150 376 ALQTLKSSLGLPLRFGWNGDPCVPQQHPWSGADCQFDSTKGKwfidgLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIR 455

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242153  108 GTIPSELGNLKNLISLDLYNNNLTGIVPTSLGKLKSLVFLRLNDNRLTGPIPRALTAIP----SLKVVDvsSNDLCGT-- 181
Cdd:PLN03150 456 GNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAALGGRLlhraSFNFTD--NAGLCGIpg 533

                        170
                 ....*....|..
gi 15242153  182 IPTNGPfaHIPL 193
Cdd:PLN03150 534 LRACGP--HLSV 543
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 77-209 1.92e-23

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 97.61  E-value: 1.92e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242153   77 LGNSNLSGHLAPELGKLEHLQYLELYKNNIQGTIPSELGNLKNLISLDLYNNNLTGIVPTSLGKLKSLVFLRLNDNRLTG 156
Cdd:PLN00113 219 LGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSG 298

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 15242153  157 PIPRALTAIPSLKVVDVSSNDLCGTIPtnGPFAHIP----LQNFENNPRLEGPELLG 209
Cdd:PLN00113 299 EIPELVIQLQNLEILHLFSNNFTGKIP--VALTSLPrlqvLQLWSNKFSGEIPKNLG 353
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 77-197 5.95e-22

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 93.37  E-value: 5.95e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242153   77 LGNSNLSGHLAPELGKLEHLQYLELYKNNIQGTIPSELGNLKNLISLDLYNNNLTGIVPTSLGKLKSLVFLRLNDNRLTG 156
Cdd:PLN00113 195 LASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSG 274

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 15242153  157 PIPRALTAIPSLKVVDVSSNDLCGTIPTngpfAHIPLQNFE 197
Cdd:PLN00113 275 PIPPSIFSLQKLISLDLSDNSLSGEIPE----LVIQLQNLE 311
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 71-204 1.91e-21

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 91.83  E-value: 1.91e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242153   71 RVTRVDLGNSNLSGHLAPELGKLEHLQYLELYKNNIQGTIPSELGNLKNLISLDLYNNNLTGIVPTSLGKLKSLVFLRLN 150
Cdd:PLN00113 476 RLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLS 555

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 15242153  151 DNRLTGPIPRALTAIPSLKVVDVSSNDLCGTIPTNGPFAHIPLQNFENNPRLEG 204
Cdd:PLN00113 556 QNQLSGEIPKNLGNVESLVQVNISHNHLHGSLPSTGAFLAINASAVAGNIDLCG 609
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 75-185 2.02e-19

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 86.06  E-value: 2.02e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242153   75 VDLGNSNLSGHLaPELGKLEHLQYLELYKNNIQGTIPSELGNLKNLISLDLYNNNLTGIVPTSLGKLKSLVFLRLNDNRL 154
Cdd:PLN00113 457 LSLARNKFFGGL-PDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQL 535

                         90       100       110
                 ....*....|....*....|....*....|.
gi 15242153  155 TGPIPRALTAIPSLKVVDVSSNDLCGTIPTN 185
Cdd:PLN00113 536 SGQIPASFSEMPVLSQLDLSQNQLSGEIPKN 566
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 71-184 1.87e-17

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 80.28  E-value: 1.87e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242153   71 RVTRVDLGNSNLSGHLAPELGKLEHLQYLELYKNNIQGTIPSELGNLKNLISLDLYNNNLTGIVPTSLGKLKSLVFLRLN 150
Cdd:PLN00113 333 RLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQ 412

                         90       100       110
                 ....*....|....*....|....*....|....
gi 15242153  151 DNRLTGPIPRALTAIPSLKVVDVSSNDLCGTIPT 184
Cdd:PLN00113 413 DNSFSGELPSEFTKLPLVYFLDISNNNLQGRINS 446
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 77-196 1.33e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 77.97  E-value: 1.33e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242153   77 LGNSNLSGHLAPELGKLEHLQYLELYKNNIQGTIPSELGNLKNLISLDLYNNNLTGIVPTSLGKLKSLVFLRLNDNRLTG 156
Cdd:PLN00113 315 LFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEG 394

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 15242153  157 PIPRALTAIPSLKVVDVSSNDLCGTIPTNgpFAHIPLQNF 196
Cdd:PLN00113 395 EIPKSLGACRSLRRVRLQDNSFSGELPSE--FTKLPLVYF 432
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
73-178 2.41e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.90  E-value: 2.41e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242153  73 TRVDLGNSNLSgHLAPELGKLEHLQYLELYKNNIQgTIPSELGNLKNLISLDLYNNNLTGIvPTSLGKLKSLVFLRLNDN 152
Cdd:COG4886 116 ESLDLSGNQLT-DLPEELANLTNLKELDLSNNQLT-DLPEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNN 192

                        90       100
                ....*....|....*....|....*.
gi 15242153 153 RLTgPIPRALTAIPSLKVVDVSSNDL 178
Cdd:COG4886 193 QIT-DLPEPLGNLTNLEELDLSGNQL 217
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 74-193 2.56e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 77.20  E-value: 2.56e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242153   74 RVDLGNSNLSGHLAPELGKLEHLQYLELYKNNIQGTIPSE-----------------LGNL------KNLISLDLYNNNL 130
Cdd:PLN00113 408 RVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRkwdmpslqmlslarnkfFGGLpdsfgsKRLENLDLSRNQF 487

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15242153  131 TGIVPTSLGKLKSLVFLRLNDNRLTGPIPRALTAIPSLKVVDVSSNDLCGTIPTNgpFAHIPL 193
Cdd:PLN00113 488 SGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPAS--FSEMPV 548
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 75-183 7.05e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 72.96  E-value: 7.05e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242153   75 VDLGNSNLSGHLAPELGKLEHLQYLELYKNNIQGTIPSELGNLKNLISLDLYNNNLTGIVPTSLGKLKSLVFLRLNDNRL 154
Cdd:PLN00113 289 LDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNL 368

                         90       100
                 ....*....|....*....|....*....
gi 15242153  155 TGPIPRALTAIPSLKVVDVSSNDLCGTIP 183
Cdd:PLN00113 369 TGEIPEGLCSSGNLFKLILFSNSLEGEIP 397
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
73-200 3.15e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 70.73  E-value: 3.15e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242153  73 TRVDLGNSNLSGhLAPELGKLEHLQYLELYKNNIQgTIPSELGNLKNLISLDLYNNNLTGIvPTSLGKLKSLVFLRLNDN 152
Cdd:COG4886 162 KSLDLSNNQLTD-LPEELGNLTNLKELDLSNNQIT-DLPEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNN 238

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 15242153 153 RLTgPIPrALTAIPSLKVVDVSSNDLcGTIPTNGPFAHIPLQNFENNP 200
Cdd:COG4886 239 QLT-DLP-ELGNLTNLEELDLSNNQL-TDLPPLANLTNLKTLDLSNNQ 283
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 70-183 1.46e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 69.11  E-value: 1.46e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242153   70 NRVTRVDLGNSNLSGHLAPELGKLEHLQYLELYKNNIQGTIPSELGNLKNLISLDLYNNNLTGIVPTSLGKLKSLVFLRL 149
Cdd:PLN00113 356 NNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDI 435

                         90       100       110
                 ....*....|....*....|....*....|....
gi 15242153  150 NDNRLTGPIPRALTAIPSLKVVDVSSNDLCGTIP 183
Cdd:PLN00113 436 SNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLP 469
LRRNT_2 pfam08263
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 27-67 1.33e-11

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 462411 [Multi-domain]  Cd Length: 41  Bit Score: 57.30  E-value: 1.33e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 15242153    27 ANSEGDALYALRRSLTDPDHVLQSWDPTLVNPCTWFHVTCN 67
Cdd:pfam08263   1 LNDDGQALLAFKSSLNDPPGALSSWNSSSSDPCSWTGVTCD 41
LRR_8 pfam13855
Leucine rich repeat;
95-154 4.46e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 4.46e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242153    95 HLQYLELYKNNIQGTIPSELGNLKNLISLDLYNNNLTGIVPTSLGKLKSLVFLRLNDNRL 154
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
89-178 1.97e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 50.70  E-value: 1.97e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242153  89 ELGKLEHLQYLELYKNNiqgtipsELGNLKNLISLDLYNNNLTGIvPTSLGKLKSLVFLRLNDNRLTgPIPRALTAIPSL 168
Cdd:COG4886  91 DLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLT-DLPEPLGNLTNL 161

                        90
                ....*....|
gi 15242153 169 KVVDVSSNDL 178
Cdd:COG4886 162 KSLDLSNNQL 171
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
94-178 7.52e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.92  E-value: 7.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242153   94 EHLQYLELYKNNIQgTIPSELGNlkNLISLDLYNNNLTGIVPTSLGKLKSLVflrLNDNRLTGpIPRALTaiPSLKVVDV 173
Cdd:PRK15370 283 EELRYLSVYDNSIR-TLPAHLPS--GITHLNVQSNSLTALPETLPPGLKTLE---AGENALTS-LPASLP--PELQVLDV 353


                 ....*
gi 15242153  174 SSNDL 178
Cdd:PRK15370 354 SKNQI 358
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 71-176 6.55e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.47  E-value: 6.55e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242153  71 RVTRVDLGNSNLSghlapELGKLEH---LQYLELYKNNIQgTIPSeLGNLKNLISLDLYNNNLTGI-------------- 133
Cdd:cd21340   3 RITHLYLNDKNIT-----KIDNLSLcknLKVLYLYDNKIT-KIEN-LEFLTNLTHLYLQNNQIEKIenlenlvnlkklyl 75

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15242153 134 ------VPTSLGKLKSLVFLRLNDNRLTGPI-----PRALTAI-PSLKVVDVSSN 176
Cdd:cd21340  76 ggnrisVVEGLENLTNLEELHIENQRLPPGEkltfdPRSLAALsNSLRVLNISGN 130
LRR_8 pfam13855
Leucine rich repeat;
119-178 1.75e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 1.75e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242153   119 NLISLDLYNNNLTGIVPTSLGKLKSLVFLRLNDNRLTGPIPRALTAIPSLKVVDVSSNDL 178
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
73-218 2.50e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.46  E-value: 2.50e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242153  73 TRVDLGNSNLSGhlAPELGKLEHLQYLELYKNNIQGTipSELGNLKNLISLDLYNNNLTGIVPTSLGKLKSLVFLRLNDN 152
Cdd:COG4886 231 ETLDLSNNQLTD--LPELGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15242153 153 RLTG--PIPRALTAIPSLKVVDVSSNDLCGTIPTNGPFAHIPLQNFENNPRLEGPELLGLASYDTNCT 218
Cdd:COG4886 307 LLNLleLLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGL 374
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 12-179 8.23e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.65  E-value: 8.23e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242153  12 AASLTLTLALIHLVEANSEGDALYALRRSLTDPDHvlqswdptlvnpctwfhvtcnqdnRVTRVDLGNSNLSGH----LA 87
Cdd:cd00116 103 SLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPP------------------------ALEKLVLGRNRLEGAsceaLA 158

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242153  88 PELGKLEHLQYLELYKNNIQG----TIPSELGNLKNLISLDLYNNNLT----GIVPTSLGKLKSLVFLRLNDNRLTGPIP 159
Cdd:cd00116 159 KALRANRDLKELNLANNGIGDagirALAEGLKANCNLEVLDLNNNGLTdegaSALAETLASLKSLEVLNLGDNNLTDAGA 238

                       170       180
                ....*....|....*....|....*
gi 15242153 160 RAL-----TAIPSLKVVDVSSNDLC 179
Cdd:cd00116 239 AALasallSPNISLLTLSLSCNDIT 263
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 94-172 1.51e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.23  E-value: 1.51e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242153  94 EHLQYLELYKNNIqgTIPSELGNLKNLISLDLYNNNLTGIVPTS--LGKLKSLVFLRLNDNRLTGPI---PRALTAIPSL 168
Cdd:cd21340 120 NSLRVLNISGNNI--DSLEPLAPLRNLEQLDASNNQISDLEELLdlLSSWPSLRELDLTGNPVCKKPkyrDKIILASKSL 197


                ....
gi 15242153 169 KVVD 172
Cdd:cd21340 198 EVLD 201
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
67-178 1.53e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 38.76  E-value: 1.53e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242153  67 NQDNRVTRVDLGNSNLSGHLAPELGKLEHLQYLELYKNNIQGTIPSELGNLKNLISLDLYNNNltgivptSLGKLKSLVF 146
Cdd:COG4886  45 LLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLES 117

                        90       100       110
                ....*....|....*....|....*....|..
gi 15242153 147 LRLNDNRLTGpIPRALTAIPSLKVVDVSSNDL 178
Cdd:COG4886 118 LDLSGNQLTD-LPEELANLTNLKELDLSNNQL 148
LRR_8 pfam13855
Leucine rich repeat;
71-130 6.40e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.04  E-value: 6.40e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15242153    71 RVTRVDLGNSNLSgHLAPE-LGKLEHLQYLELYKNNIQGTIPSELGNLKNLISLDLYNNNL 130
Cdd:pfam13855   2 NLRSLDLSNNRLT-SLDDGaFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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