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Conserved domains on  [gi|15236565|ref|NP_193490|]
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F-box protein (DUF295) [Arabidopsis thaliana]

Protein Classification

F-box protein( domain architecture ID 10459082)

F-box protein containing a DUF295 domain, may function as the substrate-recognition component of a SCF(Skp1-cullin-F-box) E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins

CATH:  1.20.1280.50
Gene Ontology:  GO:0019005|GO:0005515
PubMed:  31898225|11178263
SCOP:  4001927

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DUF295 pfam03478
Protein of unknown function (DUF295); This domain is found in plant proteins of unknown ...
297-348 1.67e-09

Protein of unknown function (DUF295); This domain is found in plant proteins of unknown function. It can be found in association with F-box domain pfam00646.


:

Pssm-ID: 460939 [Multi-domain]  Cd Length: 57  Bit Score: 53.37  E-value: 1.67e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 15236565   297 VKVDSLGDAAIILDMG--ITVVAKDIPGIKKNSIYFSGLNHPLTDPECR---FVYDL 348
Cdd:pfam03478   1 VEVKSLGDRALFLGRNcsLSVSASDFPGLKGNCIYFLTDDDDEVYKDEGrdiGVYDL 57
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
18-60 3.88e-06

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 425796  Cd Length: 43  Bit Score: 43.30  E-value: 3.88e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 15236565    18 WSELCPDLLRSIFEQLSFTNLNRAKLVCRSWNSASRGCVPKRN 60
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
 
Name Accession Description Interval E-value
DUF295 pfam03478
Protein of unknown function (DUF295); This domain is found in plant proteins of unknown ...
297-348 1.67e-09

Protein of unknown function (DUF295); This domain is found in plant proteins of unknown function. It can be found in association with F-box domain pfam00646.


Pssm-ID: 460939 [Multi-domain]  Cd Length: 57  Bit Score: 53.37  E-value: 1.67e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 15236565   297 VKVDSLGDAAIILDMG--ITVVAKDIPGIKKNSIYFSGLNHPLTDPECR---FVYDL 348
Cdd:pfam03478   1 VEVKSLGDRALFLGRNcsLSVSASDFPGLKGNCIYFLTDDDDEVYKDEGrdiGVYDL 57
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
18-60 3.88e-06

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 43.30  E-value: 3.88e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 15236565    18 WSELCPDLLRSIFEQLSFTNLNRAKLVCRSWNSASRGCVPKRN 60
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
FBOX smart00256
A Receptor for Ubiquitination Targets;
21-60 6.18e-05

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 39.73  E-value: 6.18e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 15236565     21 LCPDLLRSIFEQLSFTNLNRAKLVCRSWNSASRGCVPKRN 60
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFK 40
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
19-53 1.54e-03

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 35.88  E-value: 1.54e-03
                        10        20        30
                ....*....|....*....|....*....|....*
gi 15236565  19 SELCPDLLRSIFEQLSFTNLNRAKLVCRSWNSASR 53
Cdd:cd09917   1 SDLPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
 
Name Accession Description Interval E-value
DUF295 pfam03478
Protein of unknown function (DUF295); This domain is found in plant proteins of unknown ...
297-348 1.67e-09

Protein of unknown function (DUF295); This domain is found in plant proteins of unknown function. It can be found in association with F-box domain pfam00646.


Pssm-ID: 460939 [Multi-domain]  Cd Length: 57  Bit Score: 53.37  E-value: 1.67e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 15236565   297 VKVDSLGDAAIILDMG--ITVVAKDIPGIKKNSIYFSGLNHPLTDPECR---FVYDL 348
Cdd:pfam03478   1 VEVKSLGDRALFLGRNcsLSVSASDFPGLKGNCIYFLTDDDDEVYKDEGrdiGVYDL 57
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
18-60 3.88e-06

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 43.30  E-value: 3.88e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 15236565    18 WSELCPDLLRSIFEQLSFTNLNRAKLVCRSWNSASRGCVPKRN 60
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
FBOX smart00256
A Receptor for Ubiquitination Targets;
21-60 6.18e-05

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 39.73  E-value: 6.18e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 15236565     21 LCPDLLRSIFEQLSFTNLNRAKLVCRSWNSASRGCVPKRN 60
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFK 40
F-box-like pfam12937
F-box-like; This is an F-box-like family.
18-53 5.75e-04

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 37.08  E-value: 5.75e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 15236565    18 WSELCPDLLRSIFEQLSFTNLNRAKLVCRSWNSASR 53
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELAS 36
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
19-53 1.54e-03

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 35.88  E-value: 1.54e-03
                        10        20        30
                ....*....|....*....|....*....|....*
gi 15236565  19 SELCPDLLRSIFEQLSFTNLNRAKLVCRSWNSASR 53
Cdd:cd09917   1 SDLPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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