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Conserved domains on  [gi|1523221344|gb|RQK10570|]
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amino acid ABC transporter permease [Neisseria meningitidis]

Protein Classification

amino acid ABC transporter permease( domain architecture ID 11433582)

amino acid ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter which binds and transports amino acids

Gene Ontology:  GO:0140359|GO:0042626|GO:0006865
PubMed:  25750732|24638992
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 1-247 7.97e-69

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


:

Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 211.09  E-value: 7.97e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1523221344   1 MDFRFDIIYEYRWMFLYGALTTLGLTVVATAGGSVLGLllalarlihlekAGAPMRVLAW-ALRKVSLLYVTLFRGTPLF 79
Cdd:COG0765     1 MFFDFSVLLDYLPLLLEGLLVTLLLTVLAIVLGLVLGL------------LLALARLSPNpVLRWLATAYVEFFRGTPLL 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1523221344  80 VQIVIWayvwfpFFVHPSDGILVSgeaaialrrgygPLIAGSLALIANSGAYICEIFRAGIQSIDKGQMEAARSLGLTYP 159
Cdd:COG0765    69 VQLFFI------YFGLPLLGIDLS------------PFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRW 130

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1523221344 160 QAMRYVILPQALRRMLPPLASEFITLLKDSSLLSVIAVAELAYVQNTITGRYSVYEEPLYTVALIYLLMTTFLGWIFLRL 239
Cdd:COG0765   131 QTMRRIILPQALRIILPPLGNEFISLLKDTSLVSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRL 210


                  ....*...
gi 1523221344 240 EKRYNPQH 247
Cdd:COG0765   211 ERRLARGR 218
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 1-247 7.97e-69

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 211.09  E-value: 7.97e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1523221344   1 MDFRFDIIYEYRWMFLYGALTTLGLTVVATAGGSVLGLllalarlihlekAGAPMRVLAW-ALRKVSLLYVTLFRGTPLF 79
Cdd:COG0765     1 MFFDFSVLLDYLPLLLEGLLVTLLLTVLAIVLGLVLGL------------LLALARLSPNpVLRWLATAYVEFFRGTPLL 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1523221344  80 VQIVIWayvwfpFFVHPSDGILVSgeaaialrrgygPLIAGSLALIANSGAYICEIFRAGIQSIDKGQMEAARSLGLTYP 159
Cdd:COG0765    69 VQLFFI------YFGLPLLGIDLS------------PFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRW 130

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1523221344 160 QAMRYVILPQALRRMLPPLASEFITLLKDSSLLSVIAVAELAYVQNTITGRYSVYEEPLYTVALIYLLMTTFLGWIFLRL 239
Cdd:COG0765   131 QTMRRIILPQALRIILPPLGNEFISLLKDTSLVSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRL 210


                  ....*...
gi 1523221344 240 EKRYNPQH 247
Cdd:COG0765   211 ERRLARGR 218
PRK15100 PRK15100
cystine ABC transporter permease;
53-248 1.09e-33

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 121.01  E-value: 1.09e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1523221344  53 APMRVLA-WALRKVSLLYVTLFRGTPLFVQIVIWAYVWfpffvhPSDGILVSgeaaialrrgygPLIAGSLALIANSGAY 131
Cdd:PRK15100   41 ALMRLSPiWPVRWLARFYVSIFRGTPLIAQLFMIYYGL------PQFGIELD------------PIPAAMIGLSLNTAAY 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1523221344 132 ICEIFRAGIQSIDKGQMEAARSLGLTYPQAMRYVILPQALRRMLPPLASEFITLLKDSSLLSVIAVAELAYVQNTITGR- 210
Cdd:PRK15100  103 AAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAATIQVPELFRQAQLITSRt 182

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1523221344 211 YSVYEEPLyTVALIYLLMTTFLGWIFLRLEKRYNPQHR 248
Cdd:PRK15100  183 LEVFTMYL-AASLIYWIMATVLSALQNRFENQLNRQER 219
ectoine_ehuC TIGR03004
ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are ...
 61-242 5.34e-24

ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons. Permease subunits EhuC and EhuD are homologous.


Pssm-ID: 132049 [Multi-domain]  Cd Length: 214  Bit Score: 95.69  E-value: 5.34e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1523221344  61 ALRKVSLLYVTLFRGTPLFVQIViwayvWFpFFVHPSDGILVSgeaaialrrgygPLIAGSLALIANSGAYICEIFRAGI 140
Cdd:TIGR03004  42 ILRTVALCYIEVFRGTSLLVQLF-----WF-YFVLPLIGLSLD------------PVTTGVMVLGLHAGAYGAEIVRGAL 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1523221344 141 QSIDKGQMEAARSLGLTYPQAMRYVILPQALRRMLPPLASEFITLLKDSSLLSVIAVAELAYVQNTITGRYSVYEEPLYT 220
Cdd:TIGR03004 104 SSVSVQQLEACRALNFTRFQTLRRISLPQALVEMMPAFGNLAIELLKLTSLVSLISLADLTFAAQSIRNLTLDTLSIFAI 183

                         170       180
                  ....*....|....*....|..
gi 1523221344 221 VALIYLLMTTFLGWIFLRLEKR 242
Cdd:TIGR03004 184 TLLCYFVMALIIMLIMRVLERV 205
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 51-234 2.85e-16

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 74.24  E-value: 2.85e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1523221344  51 AGAPMRVLAWALRKVSLLYVTLFRGTPLFVQIVIWAYVWFPFFVHPSDGilvsgeaaialrrgyGPLIAGSLALIANSGA 130
Cdd:cd06261    22 LGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILP---------------GLGLPALILALLLIAP 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1523221344 131 YICEIFRAGIQSIDKGQMEAARSLGLTYPQAMRYVILPQALRRMLPPLASEFITLLKDSSLLSVIAVAELAYVQNTITGR 210
Cdd:cd06261    87 FARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPGTGLLLI 166

                         170       180
                  ....*....|....*....|....
gi 1523221344 211 YSVYEEPLYTVALIYLLMTTFLGW 234
Cdd:cd06261   167 FAILFPGDLGVAAAVALILLLLSL 190
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 60-242 4.12e-12

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 62.70  E-value: 4.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1523221344  60 WALRKVSLLYVTLFRGTPLFVqiviwayVWFPFFVHPSDGILVSGEAAIALrrgygpliagslALIANSGAYICEIFRAG 139
Cdd:pfam00528  14 RRLDRLLRPLIDLLQALPSFV-------LAILLVVIAILSILGHGILPAII------------LALLGWAGYARLIRRAA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1523221344 140 IQSIDKGQMEAARSLGLTYPQAMRYVILPQALRRMLPPLASEFITLLKDSSLLSVIAVAE---LAYVQNTITGRYSVYEE 216
Cdd:pfam00528  75 LRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPglgLLLIEAILGYDYPEIQG 154

                         170       180
                  ....*....|....*....|....*.
gi 1523221344 217 PLYTVALIYLLMTTFLGWIFLRLEKR 242
Cdd:pfam00528 155 PVLAAALILLLLNLLVDILQRLLDPR 180
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 1-247 7.97e-69

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 211.09  E-value: 7.97e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1523221344   1 MDFRFDIIYEYRWMFLYGALTTLGLTVVATAGGSVLGLllalarlihlekAGAPMRVLAW-ALRKVSLLYVTLFRGTPLF 79
Cdd:COG0765     1 MFFDFSVLLDYLPLLLEGLLVTLLLTVLAIVLGLVLGL------------LLALARLSPNpVLRWLATAYVEFFRGTPLL 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1523221344  80 VQIVIWayvwfpFFVHPSDGILVSgeaaialrrgygPLIAGSLALIANSGAYICEIFRAGIQSIDKGQMEAARSLGLTYP 159
Cdd:COG0765    69 VQLFFI------YFGLPLLGIDLS------------PFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRW 130

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1523221344 160 QAMRYVILPQALRRMLPPLASEFITLLKDSSLLSVIAVAELAYVQNTITGRYSVYEEPLYTVALIYLLMTTFLGWIFLRL 239
Cdd:COG0765   131 QTMRRIILPQALRIILPPLGNEFISLLKDTSLVSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRL 210


                  ....*...
gi 1523221344 240 EKRYNPQH 247
Cdd:COG0765   211 ERRLARGR 218
ArtM COG4160
ABC-type arginine/histidine transport system, permease component [Amino acid transport and ...
 3-248 1.28e-42

ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443325 [Multi-domain]  Cd Length: 229  Bit Score: 144.47  E-value: 1.28e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1523221344   3 FRFDIIYEYRWMFLYGALTTLGLTVVATAGGSVLGLLLalarlihlekagAPMRVLA-WALRKVSLLYVTLFRGTPLFVQ 81
Cdd:COG4160     1 MDLDLLFEYLPLLLSGLPLTLQLLALSLLLGFLLAVPL------------ALARASGnRLLRWPARGYIYVFRGTPLLVQ 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1523221344  82 IVIwAYVWFPFFvhpsDGILVSGEAAIaLRRGYGPLIagsLALIANSGAYICEIFRAGIQSIDKGQMEAARSLGLTYPQA 161
Cdd:COG4160    69 LFL-IYYGLGQF----EWVRESWLWPL-LRDPWFCAL---LALTLNTAAYTAEIFRGAIRAVPKGEIEAARALGMSRWQT 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1523221344 162 MRYVILPQALRRMLPPLASEFITLLKDSSLLSVIAVAELAYVQNTITGR-YSVYeEPLYTVALIYLLMTTFLGWIFLRLE 240
Cdd:COG4160   140 FRRIILPSALRRALPAYSNEVILMLKATALASTITVMDLTGVARRIYSRtYDPF-EPFLIAALIYLVITFLLTRLFRLLE 218


                  ....*...
gi 1523221344 241 KRYNPQHR 248
Cdd:COG4160   219 RRLLRHLR 226
PRK15100 PRK15100
cystine ABC transporter permease;
53-248 1.09e-33

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 121.01  E-value: 1.09e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1523221344  53 APMRVLA-WALRKVSLLYVTLFRGTPLFVQIVIWAYVWfpffvhPSDGILVSgeaaialrrgygPLIAGSLALIANSGAY 131
Cdd:PRK15100   41 ALMRLSPiWPVRWLARFYVSIFRGTPLIAQLFMIYYGL------PQFGIELD------------PIPAAMIGLSLNTAAY 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1523221344 132 ICEIFRAGIQSIDKGQMEAARSLGLTYPQAMRYVILPQALRRMLPPLASEFITLLKDSSLLSVIAVAELAYVQNTITGR- 210
Cdd:PRK15100  103 AAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAATIQVPELFRQAQLITSRt 182

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1523221344 211 YSVYEEPLyTVALIYLLMTTFLGWIFLRLEKRYNPQHR 248
Cdd:PRK15100  183 LEVFTMYL-AASLIYWIMATVLSALQNRFENQLNRQER 219
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 60-242 9.15e-33

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 118.62  E-value: 9.15e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1523221344  60 WALRKVSLLYVTLFRGTPLFVQiviwayVWFPFFVHPSdgilvsgeAAIALRrgYGPLIAGSLALIANSGAYICEIFRAG 139
Cdd:PRK09494   49 WIANHIALVFIELIRGTPIVVQ------VMFIYFALPM--------AFNDLR--IDPFTAAVVTIMINSGAYIAEITRGA 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1523221344 140 IQSIDKGQMEAARSLGLTYPQAMRYVILPQALRRMLPPLASEFITLLKDSSLLSVIAVAELAYV-QNTITGRYSVYEepL 218
Cdd:PRK09494  113 VLSIHKGFREAGLALGLSRRETLRYVIGPLALRRMLPPLGNQWIISIKDTSLFIVIGVAELTRQgQEIIAGNFRALE--I 190

                         170       180
                  ....*....|....*....|....*
gi 1523221344 219 YT-VALIYLLMTTFLGWIFLRLEKR 242
Cdd:PRK09494  191 WSaVAVIYLIITLVLSFILRRLERR 215
BatB COG4597
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 117-210 3.83e-25

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443651 [Multi-domain]  Cd Length: 397  Bit Score: 102.15  E-value: 3.83e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1523221344 117 LIAGSLALIANSGAYICEIFRAGIQSIDKGQMEAARSLGLTYPQAMRYVILPQALRRMLPPLASEFITLLKDSSLLSVIA 196
Cdd:COG4597   265 FVALLLALSLYTAAFIAEIVRAGIQAVSKGQTEAARALGLRPGQTLRLVVLPQALRVIIPPLTSQYLNLTKNSSLAVAIG 344

                          90
                  ....*....|....*...
gi 1523221344 197 VAELAYVQ-NTI---TGR 210
Cdd:COG4597   345 YPDLVSVFaGTTlnqTGQ 362
ectoine_ehuC TIGR03004
ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are ...
 61-242 5.34e-24

ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons. Permease subunits EhuC and EhuD are homologous.


Pssm-ID: 132049 [Multi-domain]  Cd Length: 214  Bit Score: 95.69  E-value: 5.34e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1523221344  61 ALRKVSLLYVTLFRGTPLFVQIViwayvWFpFFVHPSDGILVSgeaaialrrgygPLIAGSLALIANSGAYICEIFRAGI 140
Cdd:TIGR03004  42 ILRTVALCYIEVFRGTSLLVQLF-----WF-YFVLPLIGLSLD------------PVTTGVMVLGLHAGAYGAEIVRGAL 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1523221344 141 QSIDKGQMEAARSLGLTYPQAMRYVILPQALRRMLPPLASEFITLLKDSSLLSVIAVAELAYVQNTITGRYSVYEEPLYT 220
Cdd:TIGR03004 104 SSVSVQQLEACRALNFTRFQTLRRISLPQALVEMMPAFGNLAIELLKLTSLVSLISLADLTFAAQSIRNLTLDTLSIFAI 183

                         170       180
                  ....*....|....*....|..
gi 1523221344 221 VALIYLLMTTFLGWIFLRLEKR 242
Cdd:TIGR03004 184 TLLCYFVMALIIMLIMRVLERV 205
PRK15107 PRK15107
glutamate/aspartate ABC transporter permease GltK;
53-242 2.36e-20

glutamate/aspartate ABC transporter permease GltK;


Pssm-ID: 185062 [Multi-domain]  Cd Length: 224  Bit Score: 86.04  E-value: 2.36e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1523221344  53 APMRVLAWALRkvslLYVTLFRGTPLfVQIVIWAYVWFPFFVHPSDGIlvSGEAAIALrrgygplIAGSLALIANSGAYI 132
Cdd:PRK15107   47 SSFKPVAWFAK----AYVNVFRSIPL-VMVLLWFYLIVPGFLQNVLGL--SPKTDIRL-------ISAMVAFSMFEAAYY 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1523221344 133 CEIFRAGIQSIDKGQMEAARSLGLTYPQAMRYVILPQALRRMLPPLASEFITLLKDSSLLSVIAVAELAYVQNTITGRYS 212
Cdd:PRK15107  113 SEIIRAGIQSISRGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQGIVLFQDTSLVYVLSLADFFRTASTIGERDG 192

                         170       180       190
                  ....*....|....*....|....*....|
gi 1523221344 213 VYEEPLYTVALIYLLMTTFLGWIFLRLEKR 242
Cdd:PRK15107  193 TQVEMILFAGFVYFVISLSASLLVSYLKKR 222
PRK15069 PRK15069
histidine ABC transporter permease HisM;
68-243 6.17e-17

histidine ABC transporter permease HisM;


Pssm-ID: 185029 [Multi-domain]  Cd Length: 234  Bit Score: 77.01  E-value: 6.17e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1523221344  68 LYVTLFRGTPLFVQIVIwayvwfpffvhpsdgiLVSGEAAIALRRGYGPLIA--------GSLALIANSGAYICEIFRAG 139
Cdd:PRK15069   61 LYTYVFRGTPLYVQLLV----------------FYTGMYSLEIVRGTDLLDAffrsglncTILAFTLNTCAYTTEIFAGA 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1523221344 140 IQSIDKGQMEAARSLGLTYPQAMRYVILPQALRRMLPPLASEFITLLKDSSLLSVIAVAELAYVQNTITGRYSVYEEPLY 219
Cdd:PRK15069  125 IRSVPHGEIEAARAYGMSTFKLYRRIILPSALRRALPAYSNEVILMLHATTLAFTATVPDILKIARDINSATYQPFQAFG 204

                         170       180
                  ....*....|....*....|....
gi 1523221344 220 TVALIYLLMTTFLGWIFLRLEKRY 243
Cdd:PRK15069  205 IAAVLYLIISFVLISLFRRAERRW 228
artM PRK11122
arginine ABC transporter permease ArtM;
8-242 1.94e-16

arginine ABC transporter permease ArtM;


Pssm-ID: 182978 [Multi-domain]  Cd Length: 222  Bit Score: 75.38  E-value: 1.94e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1523221344   8 IYEYRWMFLYGALTTLGLTVVATAGGSVLGLLLALARLIHLekagapmRVLAWALRkvslLYVTLFRGTPLFVQIVIWAY 87
Cdd:PRK11122    1 MLEYLPELLKGLHTSLTLTVASLLVALVLALIFTIILTLKT-------PVLVWLVR----GYITLFTGTPLLVQIFLIYY 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1523221344  88 --------VWFPFFVHpsdgiLVSGeaaialrrgygPLIAGSLALIANSGAYICEIFRAGIQSIDKGQMEAARSLGLTYP 159
Cdd:PRK11122   70 gpgqfpwlQEYPWLWH-----LLSQ-----------PWLCAMLALALNSAAYSTQLFYGAVRAIPEGQWQSCAALGMSKK 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1523221344 160 QAMRyVILPQALRRMLPPLASEFITLLKDSSLLSVIAVAELAYVQNTITGRysVYEEPLYTVA-LIYLLMTTFLGWIFLR 238
Cdd:PRK11122  134 QTLR-ILLPYAFKRALSSYSNEVVLVFKSTSLAYTITLMDVMGYSQLLYGR--TYDVMVFGAAgIIYLVVNGLLTLLMRL 210


                  ....
gi 1523221344 239 LEKR 242
Cdd:PRK11122  211 IERK 214
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 51-234 2.85e-16

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 74.24  E-value: 2.85e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1523221344  51 AGAPMRVLAWALRKVSLLYVTLFRGTPLFVQIVIWAYVWFPFFVHPSDGilvsgeaaialrrgyGPLIAGSLALIANSGA 130
Cdd:cd06261    22 LGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILP---------------GLGLPALILALLLIAP 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1523221344 131 YICEIFRAGIQSIDKGQMEAARSLGLTYPQAMRYVILPQALRRMLPPLASEFITLLKDSSLLSVIAVAELAYVQNTITGR 210
Cdd:cd06261    87 FARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPGTGLLLI 166

                         170       180
                  ....*....|....*....|....
gi 1523221344 211 YSVYEEPLYTVALIYLLMTTFLGW 234
Cdd:cd06261   167 FAILFPGDLGVAAAVALILLLLSL 190
PRK11123 PRK11123
arginine ABC transporter permease ArtQ;
61-248 4.01e-16

arginine ABC transporter permease ArtQ;


Pssm-ID: 182979 [Multi-domain]  Cd Length: 238  Bit Score: 75.10  E-value: 4.01e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1523221344  61 ALRKVSLLYVTLFRGTPlfvQIVIwayVWFPFFVHPSDGILVSGEAAIALRRG------------YGPLIAGSLALIANS 128
Cdd:PRK11123   42 PVAWPGTALVTLLRGLP---EILV---VLFIYFGSSQLLLTLSDGFTLNLGFVqipvqmdienfeVSPFLCGVIALSLLY 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1523221344 129 GAYICEIFRAGIQSIDKGQMEAARSLGLTYPQAMRYVILPQALRRMLPPLASEFITLLKDSSLLSVIAVAELAYVQNTIT 208
Cdd:PRK11123  116 AAYASQTLRGALKAVPVGQWESGQALGLSKSAIFFRLVMPQMWRHALPGLGNQWLVLLKDTALVSLISVNDLMLQTKSIA 195

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1523221344 209 GRysvYEEPL---YTVALIYLLMTTFLGWIFLRLEKRYNPQHR 248
Cdd:PRK11123  196 TR---TQEPFtwyIIAAAIYLVITLISQYILKRIELRATRFER 235
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 60-242 4.12e-12

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 62.70  E-value: 4.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1523221344  60 WALRKVSLLYVTLFRGTPLFVqiviwayVWFPFFVHPSDGILVSGEAAIALrrgygpliagslALIANSGAYICEIFRAG 139
Cdd:pfam00528  14 RRLDRLLRPLIDLLQALPSFV-------LAILLVVIAILSILGHGILPAII------------LALLGWAGYARLIRRAA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1523221344 140 IQSIDKGQMEAARSLGLTYPQAMRYVILPQALRRMLPPLASEFITLLKDSSLLSVIAVAE---LAYVQNTITGRYSVYEE 216
Cdd:pfam00528  75 LRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPglgLLLIEAILGYDYPEIQG 154

                         170       180
                  ....*....|....*....|....*.
gi 1523221344 217 PLYTVALIYLLMTTFLGWIFLRLEKR 242
Cdd:pfam00528 155 PVLAAALILLLLNLLVDILQRLLDPR 180
PRK15135 PRK15135
histidine ABC transporter permease HisQ;
116-243 5.23e-11

histidine ABC transporter permease HisQ;


Pssm-ID: 185089 [Multi-domain]  Cd Length: 228  Bit Score: 60.58  E-value: 5.23e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1523221344 116 PLIAGSLALIANSGAYICEIFRAGIQSIDKGQMEAARSLGLTYPQAMRYVILPQALRRMLPPLASEFITLLKDSSLLSVI 195
Cdd:PRK15135   92 PMVAGIITLGFIYGAYFTETFRGAFMAVPKGHIEAATAFGFTRGQVFRRIMFPAMMRYALPGIGNNWQVILKATALVSLL 171

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1523221344 196 AVAELayVQNTITGRYSVYEEPLYTV--ALIYLLMTTFLGWIFLRLEKRY 243
Cdd:PRK15135  172 GLEDV--VKATQLAGKSTWEPFYFAIvcGVIYLVFTTVSNGVLLWLERRY 219
HEQRo_perm_3TM TIGR01726
amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This ...
 11-138 3.38e-07

amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This model represents one of several classes of multiple membrane spanning regions found immediately N-terminal to the domain described by pfam00528, binding-protein-dependent transport systems inner membrane component. The region covered by this model generally is predicted to contain three transmembrane helices. Substrate specificities attributed to members of this family include histidine, arginine, glutamine, glutamate, and (in Agrobacterium) the opines octopine and nopaline. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130787 [Multi-domain]  Cd Length: 99  Bit Score: 47.14  E-value: 3.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1523221344  11 YRWMFLYGALTTLGLTVVATAGGSVLGLLLalarlihlekagAPMRVLAWA-LRKVSLLYVTLFRGTPLFVQIviwayvW 89
Cdd:TIGR01726   1 NLPFLLKGLLLTLLLSVLSILLGLVLGLLL------------ALLRLSGNRpLRWIATVYVELFRGTPLLVQL------F 62

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1523221344  90 FPFFVHPSDGILVSgeaaialrrgygPLIAGSLALIANSGAYICEIFRA 138
Cdd:TIGR01726  63 FIYFGLPLIGIRLS------------PLTAAVIALTLFYGAYLAEIFRG 99
PhnE TIGR01097
phosphonate ABC transporter, permease protein PhnE; Phosphonates are a class of compound ...
 113-175 1.36e-06

phosphonate ABC transporter, permease protein PhnE; Phosphonates are a class of compound analogous to organic phosphates, but in which the C-O-P linkage is replaced by a direct, stable C-P bond. Some bacteria can utilize phosphonates as a source of phosphorus. This family consists of permease proteins of known or predicted phosphonate ABC transporters. Often this protein is found as a duplicated pair, occasionally as a fused pair. Certain "second" copies score in between the trusted and noise cutoff and should be considered true hits (by context). [Transport and binding proteins, Anions]


Pssm-ID: 273441 [Multi-domain]  Cd Length: 250  Bit Score: 47.92  E-value: 1.36e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1523221344 113 GYGPLiAGSLALIANSGAYICEIFRAGIQSIDKGQMEAARSLGLTYPQAMRYVILPQALRRML 175
Cdd:TIGR01097 123 GLGPF-AGVLALAFHTVGFLGKLFAEAIEEVDPGPVEALRATGASKLQVIRYGVLPQVLPQFL 184
PhnE COG3639
ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport ...
 113-175 1.45e-06

ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 442856 [Multi-domain]  Cd Length: 244  Bit Score: 47.77  E-value: 1.45e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1523221344 113 GYGPLiAGSLALIANSGAYICEIFRAGIQSIDKGQMEAARSLGLTYPQAMRYVILPQALRRML 175
Cdd:COG3639   116 GLGPF-AGVLALAIHTIGFLGKLFAEAIEEIDPGPVEALRATGASRLQVIRYGVLPQVLPQFL 177
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 106-171 1.78e-03

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 38.55  E-value: 1.78e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1523221344 106 AAIALRRGYGPLIAGSLALIAnsgAYICEIFRAGIQSIDKGQMEAARSLGLTYPQAMRYVILPQAL 171
Cdd:COG1177   123 SALGLSGGLWGLILAHVVFTL---PFVVLVVLARLQGFDPSLEEAARDLGASPWQTFRRVTLPLIA 185
TauC COG0600
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion ...
 137-171 2.48e-03

ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440365 [Multi-domain]  Cd Length: 254  Bit Score: 38.21  E-value: 2.48e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1523221344 137 RAGIQSIDKGQMEAARSLGLTYPQAMRYVILPQAL 171
Cdd:COG0600   145 AAGVRSVDPELLELARSLGASRWQILRKVVLPAAL 179
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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