|
Name |
Accession |
Description |
Interval |
E-value |
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
7-472 |
1.28e-127 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 377.71 E-value: 1.28e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 7 AAQPRIGLSEKVGYGLGDMASNLYFQFFNLFLFYYYTDVFGLNPAAIGTMYLVANFWDAVNDPLMGAIADRVQTAKGKYR 86
Cdd:COG2211 2 AAKKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRRR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 87 PFLLWFAIPYGLAGYAIFANPDFSEVGKLAYAYTTFIVFKMIYTAINVPYSALMGVITPDANDRMALSTFRFLGAFGGGF 166
Cdd:COG2211 82 PWILIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 167 IVSLLVRPLVKLFGGdDEVLGFQLTMAVFGVASILMFLITYASTRERVKPQAEEKdmSVKEDLKLLCRNLPWLIMIGAAV 246
Cdd:COG2211 162 LASVLPPPLVAAFGG-DAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKV--SLKESLKALLKNRPFLLLLLAYL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 247 CTLANVAVRGAVTIHYFKYYVGNSAEAVfsigqsgtafflefdatTIFMSTGMIAFIIGVAFTGIIGRTFGKRNALATLT 326
Cdd:COG2211 239 LFFLALALVAALLLYYFKYVLGLSAALV-----------------GLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGL 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 327 LLNAATIIGFYFIPPEATATMYVVNLLANLLAGPTPALVWALYTDVADYGEWKFGRRATGLVFSAAMFAQKMGLTIGGAA 406
Cdd:COG2211 302 LLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGAL 381
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1519714020 407 SGWLLAGFGFVANQDQTPEALMGIRIMFCIIPGALALLNGFILIFYPLSTRETEQMQSELEDRRKA 472
Cdd:COG2211 382 AGLLLALFGYVAGAAQSPSALTGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAEIRAELAARRAA 447
|
|
| PRK09669 |
PRK09669 |
putative symporter YagG; Provisional |
11-466 |
2.45e-121 |
|
putative symporter YagG; Provisional
Pssm-ID: 236610 Cd Length: 444 Bit Score: 361.74 E-value: 2.45e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 11 RIGLSEKVGYGLGDMASNLYFQFFNLFLFYYYTDVFGLNPAAIGTMYLVANFWDAVNDPLMGAIADRVQTAKGKYRPFLL 90
Cdd:PRK09669 5 QLTTKDKIGYGLGDTACNLVWQTVMLFLAYFYTDVFGLSAAIMGTMFLVVRVLDAVTDPLMGALVDRTRTRHGQFRPYLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 91 WFAIPYGLAGYAIFANPDFSEVGKLAYAYTTFIVFKMIYTAINVPYSALMGVITPDANDRMALSTFRFLGAFGGGFIVSL 170
Cdd:PRK09669 85 WFAIPFGVVCLLTFYTPDFGATGKIIYACVTYILLSLVYTAINVPYCAMPGAITNDPRERHSLQSWRFALSFIGGLIVSV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 171 LVRPLVKLFGGDDEVLGFQLTMAVFGVASILMFLITYASTRERVKPQAEEKDmSVKEDLKLLCRNLPWLIMIGAAVCTLA 250
Cdd:PRK09669 165 IALPLVDILGKGDEQKGYFYAMMVMGLLGVVLFFCCFFMTKERYTPEVDNSS-SVWKDLKLLLGNSQWRIMFIFNVVLLT 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 251 NVAVRGAVTIHYFKYYVGNSaeavfsigqsgtafflefDATTIFMSTGMIAFIIGVAFTGIIGRTFGKRNALATLTLLNA 330
Cdd:PRK09669 244 AVVTRGGATLYYVNYVLLRP------------------DLATLFLVTGMIAGLFGALLSERLLGKFDRVRAFKWTIVAFV 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 331 ATIIGFYFIPPEATATMYVVNLLANLLAGPTPALVWALYTDVADYGEWKFGRRATGLVFSAAMFAQKMGLTIGGAASGWL 410
Cdd:PRK09669 306 ILSALIFFIPPSNVWLIFALNILFNFIQNLTTPLQWSMFSDVVDYEEKRSGRRLDGLVFSTNLFAIKLGLAIGGAVVGWI 385
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 1519714020 411 LAGFGFVANQD-QTPEALMGIRIMFCIIPGALALLNGFILIFYPLSTRETEQMQSEL 466
Cdd:PRK09669 386 LAWVDYVGGAAvQSASVLTTINLLFTVIPGVLFAGMAIILNFYKLNDARVEAIAQEL 442
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
17-456 |
2.92e-118 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 353.06 E-value: 2.92e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 17 KVGYGLGDMASNLYFQFFNLFLFYYYTDVFGLNPAAIGTMYLVANFWDAVNDPLMGAIADRVQTAKGKYRPFLLWFAIPY 96
Cdd:cd17332 1 KIGYGLGDFGNNLIFQIVSTYLLFFYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTRSRWGRFRPWLLWGAIPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 97 GLAGYAIFANPDFSEVGKLAYAYTTFIVFKMIYTAINVPYSALMGVITPDANDRMALSTFRFLGAFGGGFIVSLLVRPLV 176
Cdd:cd17332 81 ALLFVLLFTTPDGSGTGKLIYALITYILLDLLYTLVNIPYTALIPELTDDPEERTSLTSWRMFFATIGGLLVTVLPPPLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 177 KLFGGDDEVLGFQLTMAVFGVASILMFLITYASTRERVKPQAEEKDM-SVKEDLKLLCRNLPWLIMIGAAVCTLANVAVR 255
Cdd:cd17332 161 AYFGGGNASRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEKSKlPLLKSLKALLKNRPFLILLLAYLLYFLAFNIV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 256 GAVTIHYFKYYVGNSAEAVFSIGqsgtafflefdattIFMSTGMIAFIIGVAFTgiigRTFGKRNALATLTLLNAATIIG 335
Cdd:cd17332 241 NTVLVYYFKYVLGGRAELVLLLL--------------LILSGALLALLPWPPLK----KRFGKKKAFFIGLLLAILGLLL 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 336 FYFIPPEATATMYVVNLLANLLAGPTPALVWALYTDVADYGEWKFGRRATGLVFSAAMFAQKMGLTIGGAASGWLLAGFG 415
Cdd:cd17332 303 LFFLPPGNLVLILVLAVLAGIGYGGANLLPWAMLADVIDYGELKTGKRREGIFYSVMTFFRKLGLALAGALVGLILSLAG 382
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 1519714020 416 FVAN-QDQTPEALMGIRIMFCIIPGALALLNGFILIFYPLST 456
Cdd:cd17332 383 YVANaAAQSASALNGIRLLIAVLPAVLLLLALILMSFYPLDK 424
|
|
| gph |
TIGR00792 |
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH): ... |
17-469 |
1.81e-117 |
|
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family (TC 2.A.2) GPH:cation symporters catalyze uptake of sugars in symport with a monovalent cation (H+ or Na+). Members of this family includes transporters for melibiose, lactose, raffinose, glucuronides, pentosides and isoprimeverose. Mutants of two groups of these symporters (the melibiose permeases of enteric bacteria, and the lactose permease of Streptococcus thermophilus) have been isolated in which altered cation specificity is observed or in which sugar transport is uncoupled from cation symport (i.e., uniport is catalyzed). The various members of the family can use Na+, H+ or Li, Na+ or Li+, H+ or Li+, or only H+ as the symported cation. All of these proteins possess twelve putative transmembrane a-helical spanners. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273270 Cd Length: 437 Bit Score: 351.55 E-value: 1.81e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 17 KVGYGLGDMASNLYFQFFNLFLFYYYTDVFGLNPAAIGTMYLVANFWDAVNDPLMGAIADRVQTAKGKYRPFLLWFAIPY 96
Cdd:TIGR00792 1 KLSYGFGDFGNDFIFAIVSTYLLFFYTDVLGLSAAFVGTLFLVARILDAITDPIMGNIVDRTRTRWGKFRPWLLIGAIPF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 97 GLAGYAIFANPDFSEVGKLAYAYTTFIVFKMIYTAINVPYSALMGVITPDANDRMALSTFRFLGAFGGGFIVSLLVRPLV 176
Cdd:TIGR00792 81 SIVLVLLFTTPDFSGTGKLVYAYITYILLGLFYSFVNIPYWSLVPAITLDPRERESLSTFRRFGATLGGLLVAVIVLPLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 177 KLFGGDDEVLGFQLTMAVFGVASILMFLITYASTRERVK--PQAEEKDMSVKEDLKLLCRNLPWLIMIGAAVCTLANVAV 254
Cdd:TIGR00792 161 SYFGGGDDKFGWFMFALVLALIGVVSLIICFFGTKERYSeiPKNIEKKLSLKQIFKALFKNDQLLILCLAYLFYNLAFNI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 255 RGAVTIHYFKYYVGNSAEAvfsigqsgtafflefdatTIFMSTGMIAFIIGVAFTGIIGRTFGKRNALATLTLLNAATII 334
Cdd:TIGR00792 241 KNGVQVYYFTYVLGDPELF------------------SYMGSIAIVAGLIGVLLFPRLVKKFGRKILFAGGILLMVLGYL 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 335 GFYFiPPEATATMYVVNLLANLLAGPTPALVWALYTDVADYGEWKFGRRATGLVFSAAMFAQKMGLTIGGAASGWLLAGF 414
Cdd:TIGR00792 303 IFFF-AGSNLPLILVLIILAGFGQNIVTGLVWALVADTVDYGEWKTGIRAEGLVYSVRTFVRKLGQALAGFFVGLILGII 381
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 1519714020 415 GFVANQDQTPEALMGIRIMFCIIPGALALLNGFIL-IFYPLSTRETEQMQSELEDR 469
Cdd:TIGR00792 382 GYVANAAQSPITLNGIKILMFAVPALFLLLAAIIIgRFYKLTEKKHAEIVEELEQR 437
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
19-455 |
1.74e-81 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 258.78 E-value: 1.74e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 19 GYGLGDMASNLYFQFFNLFLFYYYTDVFGLNPAAIGTMYLVANFWDAVNDPLMGAIADRVQTAKGKYRPFLLWFAIPYGL 98
Cdd:pfam13347 1 GYGSGALAAGIKYAGLATYLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWGRRRPWLLLSAIILAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 99 AGYAIFANPDFSEVGKLAYAYTTFIVFKMIYTAINVPYSALMGVITPDANDRMALSTFRFLGAFGGGFIVSLLVRPLVKL 178
Cdd:pfam13347 81 SFILLFTPPELGRAPLFIWLLATYILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFFSVGGGLLAAALAFPLVLI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 179 FGGD-DEVLGFQLTMAVFGVASILMFLITYASTRERVKPQAEEKDM-----SVKEDLKLLCRNLPWLIMIGAAVCTLANV 252
Cdd:pfam13347 161 LGGTgLERKGYRIFALIGAVLMLLGVIITAAGTKERVSMRSKEDTGqkeagSLLDMLKEVFRNRAFLILLASFLLAALAM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 253 AVRGAVTIHYFKYYVGNSAEAvfsigqsgtafflefdatTIFMSTGMIAFIIGVAFTGIIGRTFGKRNALATLTLLNAAT 332
Cdd:pfam13347 241 GVLNGLLLYYFRYVLGNGFAA------------------SAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAG 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 333 IIGFYFIPPEATATMYVVNLLANLLAGPTPALVWALYTDVADYGEWKFGRRATGLVFSAAMFAQKMGLTIGGAASGWLLA 412
Cdd:pfam13347 303 FALALLLGPNNTLLFLVLYIIIGFGYGSSFFLPWSMLADVVDYGELRTGKRREGTFFAMWSFISKLATGVGLGVSGLLLS 382
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 1519714020 413 GFGFVA-NQDQTPEALMGIRIMFCIIPGALALLNGFILIFYPLS 455
Cdd:pfam13347 383 AFGYNAgDSVQSPQAVTAIRLLYAVLPAVLFLVALLLLYFYPLD 426
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
7-472 |
1.28e-127 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 377.71 E-value: 1.28e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 7 AAQPRIGLSEKVGYGLGDMASNLYFQFFNLFLFYYYTDVFGLNPAAIGTMYLVANFWDAVNDPLMGAIADRVQTAKGKYR 86
Cdd:COG2211 2 AAKKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRRR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 87 PFLLWFAIPYGLAGYAIFANPDFSEVGKLAYAYTTFIVFKMIYTAINVPYSALMGVITPDANDRMALSTFRFLGAFGGGF 166
Cdd:COG2211 82 PWILIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 167 IVSLLVRPLVKLFGGdDEVLGFQLTMAVFGVASILMFLITYASTRERVKPQAEEKdmSVKEDLKLLCRNLPWLIMIGAAV 246
Cdd:COG2211 162 LASVLPPPLVAAFGG-DAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKV--SLKESLKALLKNRPFLLLLLAYL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 247 CTLANVAVRGAVTIHYFKYYVGNSAEAVfsigqsgtafflefdatTIFMSTGMIAFIIGVAFTGIIGRTFGKRNALATLT 326
Cdd:COG2211 239 LFFLALALVAALLLYYFKYVLGLSAALV-----------------GLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGL 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 327 LLNAATIIGFYFIPPEATATMYVVNLLANLLAGPTPALVWALYTDVADYGEWKFGRRATGLVFSAAMFAQKMGLTIGGAA 406
Cdd:COG2211 302 LLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGAL 381
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1519714020 407 SGWLLAGFGFVANQDQTPEALMGIRIMFCIIPGALALLNGFILIFYPLSTRETEQMQSELEDRRKA 472
Cdd:COG2211 382 AGLLLALFGYVAGAAQSPSALTGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAEIRAELAARRAA 447
|
|
| PRK09669 |
PRK09669 |
putative symporter YagG; Provisional |
11-466 |
2.45e-121 |
|
putative symporter YagG; Provisional
Pssm-ID: 236610 Cd Length: 444 Bit Score: 361.74 E-value: 2.45e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 11 RIGLSEKVGYGLGDMASNLYFQFFNLFLFYYYTDVFGLNPAAIGTMYLVANFWDAVNDPLMGAIADRVQTAKGKYRPFLL 90
Cdd:PRK09669 5 QLTTKDKIGYGLGDTACNLVWQTVMLFLAYFYTDVFGLSAAIMGTMFLVVRVLDAVTDPLMGALVDRTRTRHGQFRPYLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 91 WFAIPYGLAGYAIFANPDFSEVGKLAYAYTTFIVFKMIYTAINVPYSALMGVITPDANDRMALSTFRFLGAFGGGFIVSL 170
Cdd:PRK09669 85 WFAIPFGVVCLLTFYTPDFGATGKIIYACVTYILLSLVYTAINVPYCAMPGAITNDPRERHSLQSWRFALSFIGGLIVSV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 171 LVRPLVKLFGGDDEVLGFQLTMAVFGVASILMFLITYASTRERVKPQAEEKDmSVKEDLKLLCRNLPWLIMIGAAVCTLA 250
Cdd:PRK09669 165 IALPLVDILGKGDEQKGYFYAMMVMGLLGVVLFFCCFFMTKERYTPEVDNSS-SVWKDLKLLLGNSQWRIMFIFNVVLLT 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 251 NVAVRGAVTIHYFKYYVGNSaeavfsigqsgtafflefDATTIFMSTGMIAFIIGVAFTGIIGRTFGKRNALATLTLLNA 330
Cdd:PRK09669 244 AVVTRGGATLYYVNYVLLRP------------------DLATLFLVTGMIAGLFGALLSERLLGKFDRVRAFKWTIVAFV 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 331 ATIIGFYFIPPEATATMYVVNLLANLLAGPTPALVWALYTDVADYGEWKFGRRATGLVFSAAMFAQKMGLTIGGAASGWL 410
Cdd:PRK09669 306 ILSALIFFIPPSNVWLIFALNILFNFIQNLTTPLQWSMFSDVVDYEEKRSGRRLDGLVFSTNLFAIKLGLAIGGAVVGWI 385
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 1519714020 411 LAGFGFVANQD-QTPEALMGIRIMFCIIPGALALLNGFILIFYPLSTRETEQMQSEL 466
Cdd:PRK09669 386 LAWVDYVGGAAvQSASVLTTINLLFTVIPGVLFAGMAIILNFYKLNDARVEAIAQEL 442
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
17-456 |
2.92e-118 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 353.06 E-value: 2.92e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 17 KVGYGLGDMASNLYFQFFNLFLFYYYTDVFGLNPAAIGTMYLVANFWDAVNDPLMGAIADRVQTAKGKYRPFLLWFAIPY 96
Cdd:cd17332 1 KIGYGLGDFGNNLIFQIVSTYLLFFYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTRSRWGRFRPWLLWGAIPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 97 GLAGYAIFANPDFSEVGKLAYAYTTFIVFKMIYTAINVPYSALMGVITPDANDRMALSTFRFLGAFGGGFIVSLLVRPLV 176
Cdd:cd17332 81 ALLFVLLFTTPDGSGTGKLIYALITYILLDLLYTLVNIPYTALIPELTDDPEERTSLTSWRMFFATIGGLLVTVLPPPLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 177 KLFGGDDEVLGFQLTMAVFGVASILMFLITYASTRERVKPQAEEKDM-SVKEDLKLLCRNLPWLIMIGAAVCTLANVAVR 255
Cdd:cd17332 161 AYFGGGNASRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEKSKlPLLKSLKALLKNRPFLILLLAYLLYFLAFNIV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 256 GAVTIHYFKYYVGNSAEAVFSIGqsgtafflefdattIFMSTGMIAFIIGVAFTgiigRTFGKRNALATLTLLNAATIIG 335
Cdd:cd17332 241 NTVLVYYFKYVLGGRAELVLLLL--------------LILSGALLALLPWPPLK----KRFGKKKAFFIGLLLAILGLLL 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 336 FYFIPPEATATMYVVNLLANLLAGPTPALVWALYTDVADYGEWKFGRRATGLVFSAAMFAQKMGLTIGGAASGWLLAGFG 415
Cdd:cd17332 303 LFFLPPGNLVLILVLAVLAGIGYGGANLLPWAMLADVIDYGELKTGKRREGIFYSVMTFFRKLGLALAGALVGLILSLAG 382
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 1519714020 416 FVAN-QDQTPEALMGIRIMFCIIPGALALLNGFILIFYPLST 456
Cdd:cd17332 383 YVANaAAQSASALNGIRLLIAVLPAVLLLLALILMSFYPLDK 424
|
|
| gph |
TIGR00792 |
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH): ... |
17-469 |
1.81e-117 |
|
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family (TC 2.A.2) GPH:cation symporters catalyze uptake of sugars in symport with a monovalent cation (H+ or Na+). Members of this family includes transporters for melibiose, lactose, raffinose, glucuronides, pentosides and isoprimeverose. Mutants of two groups of these symporters (the melibiose permeases of enteric bacteria, and the lactose permease of Streptococcus thermophilus) have been isolated in which altered cation specificity is observed or in which sugar transport is uncoupled from cation symport (i.e., uniport is catalyzed). The various members of the family can use Na+, H+ or Li, Na+ or Li+, H+ or Li+, or only H+ as the symported cation. All of these proteins possess twelve putative transmembrane a-helical spanners. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273270 Cd Length: 437 Bit Score: 351.55 E-value: 1.81e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 17 KVGYGLGDMASNLYFQFFNLFLFYYYTDVFGLNPAAIGTMYLVANFWDAVNDPLMGAIADRVQTAKGKYRPFLLWFAIPY 96
Cdd:TIGR00792 1 KLSYGFGDFGNDFIFAIVSTYLLFFYTDVLGLSAAFVGTLFLVARILDAITDPIMGNIVDRTRTRWGKFRPWLLIGAIPF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 97 GLAGYAIFANPDFSEVGKLAYAYTTFIVFKMIYTAINVPYSALMGVITPDANDRMALSTFRFLGAFGGGFIVSLLVRPLV 176
Cdd:TIGR00792 81 SIVLVLLFTTPDFSGTGKLVYAYITYILLGLFYSFVNIPYWSLVPAITLDPRERESLSTFRRFGATLGGLLVAVIVLPLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 177 KLFGGDDEVLGFQLTMAVFGVASILMFLITYASTRERVK--PQAEEKDMSVKEDLKLLCRNLPWLIMIGAAVCTLANVAV 254
Cdd:TIGR00792 161 SYFGGGDDKFGWFMFALVLALIGVVSLIICFFGTKERYSeiPKNIEKKLSLKQIFKALFKNDQLLILCLAYLFYNLAFNI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 255 RGAVTIHYFKYYVGNSAEAvfsigqsgtafflefdatTIFMSTGMIAFIIGVAFTGIIGRTFGKRNALATLTLLNAATII 334
Cdd:TIGR00792 241 KNGVQVYYFTYVLGDPELF------------------SYMGSIAIVAGLIGVLLFPRLVKKFGRKILFAGGILLMVLGYL 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 335 GFYFiPPEATATMYVVNLLANLLAGPTPALVWALYTDVADYGEWKFGRRATGLVFSAAMFAQKMGLTIGGAASGWLLAGF 414
Cdd:TIGR00792 303 IFFF-AGSNLPLILVLIILAGFGQNIVTGLVWALVADTVDYGEWKTGIRAEGLVYSVRTFVRKLGQALAGFFVGLILGII 381
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 1519714020 415 GFVANQDQTPEALMGIRIMFCIIPGALALLNGFIL-IFYPLSTRETEQMQSELEDR 469
Cdd:TIGR00792 382 GYVANAAQSPITLNGIKILMFAVPALFLLLAAIIIgRFYKLTEKKHAEIVEELEQR 437
|
|
| PRK11462 |
PRK11462 |
putative transporter; Provisional |
12-466 |
1.59e-84 |
|
putative transporter; Provisional
Pssm-ID: 183145 Cd Length: 460 Bit Score: 267.57 E-value: 1.59e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 12 IGLSEKVGYGLGDMASNLYFQFFNLFLFYYYTDVFGLNPAAIGTMYLVANFWDAVNDPLMGAIADRVQTAKGKYRPFLLW 91
Cdd:PRK11462 6 LSVKEKIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLVARALDAISDPCMGLLADRTRSRWGKFRPWVLF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 92 FAIPYGLAGYAIFANPDFSEVGKLAYAYTTFIVFKMIYTAINVPYSALMGVITPDANDRMALSTFRFLGAFGGGFIVSLL 171
Cdd:PRK11462 86 GALPFGIVCVLAYSTPDLSMNGKMIYAAITYTLLTLLYTVVNIPYCALGGVITNDPTQRISLQSWRFVLATAGGMLSTVL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 172 VRPLVKLFGGDDEVLGFQLTMAVFGVASILMFLITYASTRERVkpQAEEKDMSVKEDLKLLCRNLPWLIMIGAAVCTLAN 251
Cdd:PRK11462 166 MMPLVNLIGGDNKPLGFQGGIAVLSVVAFMMLAFCFFTTKERV--EAPPTTTSMREDLRDIWQNDQWRIVGLLTIFNILA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 252 VAVRGAVTIHYFKYYVGNSaeAVFsigqsgtafflefdatTIFMSTGMIAFIIGVAFTGIIGRTFGKRNALATLTLLNAA 331
Cdd:PRK11462 244 VCVRGGAMMYYVTWILGTP--EVF----------------VAFLTTYCVGNLIGSALAKPLTDWKCKVTIFWWTNALLAV 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 332 TIIGFYFIPPEATATMYVVNLLANLLAGPTPALVWALYTDVADYGEWKFGRRATGLVFSAAMFAQKMGLTIGGAASGWLL 411
Cdd:PRK11462 306 ISLAMFFVPMQASITMFVFIFVIGVLHQLVTPIQWVMMSDTVDYGEWCNGKRLTGISFAGTLFVLKLGLAFGGALIGWML 385
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 1519714020 412 AGFGFVANQDQTPEALMGIRI-MFCIIPGALALLNGFILI-FYPLSTRETEQMQSEL 466
Cdd:PRK11462 386 AYGGYDAAEKAQNSATISIIIaLFTIVPAICYLLSAIIAKrYYSLTTHNLKTVMEQL 442
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
19-455 |
1.74e-81 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 258.78 E-value: 1.74e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 19 GYGLGDMASNLYFQFFNLFLFYYYTDVFGLNPAAIGTMYLVANFWDAVNDPLMGAIADRVQTAKGKYRPFLLWFAIPYGL 98
Cdd:pfam13347 1 GYGSGALAAGIKYAGLATYLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWGRRRPWLLLSAIILAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 99 AGYAIFANPDFSEVGKLAYAYTTFIVFKMIYTAINVPYSALMGVITPDANDRMALSTFRFLGAFGGGFIVSLLVRPLVKL 178
Cdd:pfam13347 81 SFILLFTPPELGRAPLFIWLLATYILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFFSVGGGLLAAALAFPLVLI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 179 FGGD-DEVLGFQLTMAVFGVASILMFLITYASTRERVKPQAEEKDM-----SVKEDLKLLCRNLPWLIMIGAAVCTLANV 252
Cdd:pfam13347 161 LGGTgLERKGYRIFALIGAVLMLLGVIITAAGTKERVSMRSKEDTGqkeagSLLDMLKEVFRNRAFLILLASFLLAALAM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 253 AVRGAVTIHYFKYYVGNSAEAvfsigqsgtafflefdatTIFMSTGMIAFIIGVAFTGIIGRTFGKRNALATLTLLNAAT 332
Cdd:pfam13347 241 GVLNGLLLYYFRYVLGNGFAA------------------SAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAG 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 333 IIGFYFIPPEATATMYVVNLLANLLAGPTPALVWALYTDVADYGEWKFGRRATGLVFSAAMFAQKMGLTIGGAASGWLLA 412
Cdd:pfam13347 303 FALALLLGPNNTLLFLVLYIIIGFGYGSSFFLPWSMLADVVDYGELRTGKRREGTFFAMWSFISKLATGVGLGVSGLLLS 382
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 1519714020 413 GFGFVA-NQDQTPEALMGIRIMFCIIPGALALLNGFILIFYPLS 455
Cdd:pfam13347 383 AFGYNAgDSVQSPQAVTAIRLLYAVLPAVLFLVALLLLYFYPLD 426
|
|
| PRK09848 |
PRK09848 |
glucuronide transporter; Provisional |
18-473 |
2.25e-77 |
|
glucuronide transporter; Provisional
Pssm-ID: 182109 [Multi-domain] Cd Length: 448 Bit Score: 248.55 E-value: 2.25e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 18 VGYGLGDMASNLYFQFFNLFLFYYYTDVFGLNPAAIGTMYLVANFWDAVNDPLMGAIADRVQTAKGKYRPFLLWFAIPYG 97
Cdd:PRK09848 11 VGYSLGDVANNFAFAMGALFLLSYYTDVAGVGAAAAGTMLLLVRVFDAFADVFAGRVVDSVNTRWGKFRPFLLFGTAPLM 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 98 LAGYAIFANP-DFSEVGKLAYAYTTFIVFKMIYTAINVPYSALMGVITPDANDRMALSTFRFLGAFGGGFIVSLLVRPLV 176
Cdd:PRK09848 91 IFSVLVFWVPtDWSHSSKVVYAYLTYMGLGLCYSLVNIPYGSLATAMTQQPQSRARLGAARGIAASLTFVCLAFLIGPSI 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 177 KLFGGDDEVLGFQLTMAVFGVASILMFLITYASTRERVKPQAEEKdmSVKEDLKLLCRNLPWLIMIGAAVCTLANVAVRG 256
Cdd:PRK09848 171 KNSSPEEMVSVYHFWTIVLAIAGMVLYFICFKSTRENVVRIVAQP--SLKISLQTLKRNRPLFMLCIGALCVLISTFAVS 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 257 AVTIHYFKYYVGNsaeavfsigqsgTAFFlefdaTTIFMSTGMIAFIIGVAFTGIIGRTFGKRNALATLTLLNAATIIGF 336
Cdd:PRK09848 249 ASSLFYVRYVLND------------TGLF-----TVLVLVQNLVGTVASAPLVPGMVARIGKKNTFLIGALLGTCGYLLF 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 337 YFIPPEATATMYVVNLLANLLAGPTPALVWALYTDVADYGEWKFGRRATGLVFSAAMFAQKMGLTIGGAASGWLLAGFGF 416
Cdd:PRK09848 312 FWVSVWSLPVALVALAIASIGQGVTMTVMWALEADTVEYGEYLTGVRIEGLTYSLFSFTRKCGQAIGGSIPAFILGLSGY 391
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 1519714020 417 VANQDQTPEALMGIRIMFCIIPGALALLNGFILIFYPLSTRETEQMQSELEDRRKAA 473
Cdd:PRK09848 392 IANQVQTPEVIMGIRTSIALVPCGFMLLAFVIIWFYPLTDKKFKEIVVEIDNRKKVQ 448
|
|
| PRK10429 |
PRK10429 |
melibiose:sodium transporter MelB; |
12-471 |
5.26e-52 |
|
melibiose:sodium transporter MelB;
Pssm-ID: 182453 Cd Length: 473 Bit Score: 182.60 E-value: 5.26e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 12 IGLSEKVGYGLGDMASNLYFQFFNLFLFYYYTDVFGLNPAAIGTMYLVANFWDAVNDPLMGAIADRVQTAKGKYRPFLLW 91
Cdd:PRK10429 3 ISMTTKLSYGFGAFGKDFAIGIVYMYLMYYYTDVVGLSVGLVGTLFLVARIWDAINDPIMGWIVNNTRSRWGKFKPWILI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 92 FAIPYGLAGYAIFANPDFSEVGKLAYAYTTFIVFKMIYTAINVPYSALMGVITPDANDRMALSTF-RFLGAFgGGFIVSL 170
Cdd:PRK10429 83 GTLANSVVLFLLFSAHLFEGTAQYVFVCVTYILWGMTYTIMDIPFWSLVPTLTLDKREREQLVPYpRFFASL-AGFVTAG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 171 LVRPLVKLFGGDDEVLGFQltmaVFGVASILMFLITYASTRERVK--------PQAEEKDMSVKEDLKLLCRNLPWLIMI 242
Cdd:PRK10429 162 FTLPFVNYVGGGDRGFGFQ----MFTLVLIAFFIVSTIITLRNVHevyssdnqVSAEGSHLTLKDIVALIYKNDQLSCLL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 243 GAAVCTLANVAVRGAVTIHYFKYYVGNsaEAVFSigqsgtafflefdattIFMSTGMIAFIIGVAFTGIIGRTFGKRNAL 322
Cdd:PRK10429 238 GMALAYNIASNIINGFAIYYFTYVIGD--ADLFP----------------YYLSYAGAANLVTLILFPRLVKSLSRRILW 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 323 AT---LTLLNAATIIGFYFIPPEATATMYVVNLLANLLAGPTPALVWALYTDVADYGEWKFGRRATGLVFSAAMFAQKMG 399
Cdd:PRK10429 300 AGasiFPVLSCGVLLLMGLAAPHNALLIVIAGILLNIGTALFWVLQVIMVADTVDYGEYKLGIRCESIAYSVQTMVVKGG 379
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1519714020 400 LTIGGAASGWLLAGFGFVANQDQTPEALMGIRIMFCIIPGALALLNGFILI-FYPLSTRETEQMQSELEDRRK 471
Cdd:PRK10429 380 SAFAAFFIGVVLGLIGYVPNVEQSAQTLLGMQFIMIGLPTLFFMITLVLYFrYYRLNGDFLRRIQIHLLDKYR 452
|
|
| MFS_MFSD2B |
cd17452 |
Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily ... |
17-455 |
1.47e-09 |
|
Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily domain-containing protein 2B (MFSD2B) is closely related to MFSD2A, and their conserved genomic structure suggests that they are derived from the duplication of an ancestral gene. Variations of chromosome 2 gene expressions among patients with lung cancer or non-cancer identified MFSD2B as a potential risk or protect factor in the prognosis of lung adenocarcinoma. MFSD2B belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341010 Cd Length: 416 Bit Score: 59.83 E-value: 1.47e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 17 KVGYGLGDMASNLYFQFFNLFLFYYYTDVFGLNPAAIGTMYLVANFWDAVNDPLMGAIADRVQ-TAKGKYRP-------- 87
Cdd:cd17452 1 KLCYAIGGAPNQVAGSATAFFLQIYLLDIAQITPFQASLVLFVGKAWGAATDPVVGFFISKSKwTKIGRLMPwmlgctpf 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 88 -----FLLWFAIPYglagyaifanpdfsEVGKLAYAYTTFIVFKMIYTAINVPYSALMGVITPDANDRMALSTFRF---- 158
Cdd:cd17452 81 ivvsyFFLWFVPPF--------------TTGRFLWYLTFYCLFQALATCFHVPYSALTMFLSTDQRERDSATAYRMtvev 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 159 LGAFGGGFIVSLLVRPlvklfggddevlGFQLTMAVFGVASILMFLITYASTRERVKPQAEEKDMSVK--EDLKLLCRNL 236
Cdd:cd17452 147 LGTLVGAAVQGQIVAS------------AYMIAAGVIGGLYLLCISVLFLGVKERDDPYAPKSGKAIPffKGLSLTMRHG 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 237 PWLIMIGAAVCTLANVAVRgavtihyfkyyvgNSAEAVFSIGQSGTAFFLEFDATTIFMSTgmiafIIGVAFTGIIGRTF 316
Cdd:cd17452 215 PYLKLTASFLFISAAVQLE-------------QSNFVLFCTHAVDLHDHFQNLVLTILVSA-----VVSIPFWQWFLQRF 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 317 GKRNALATLTLLNAATIIgFYFIPPEATAtmYVVNLLANLLAGPTPALVWALYTDVADYGEWK--FGRRATGLVFSAAMF 394
Cdd:cd17452 277 GKKAAACGISWMIPFAIM-LVTIPNLIVA--YVVAFVSGLSIAASLLLPWSMLPDVVDDFRLQnpHGKGLETIFYSSYVF 353
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1519714020 395 AQKMGLTIGGAASGWLLAGFGFVANQ-DQTPEALMGIRIMFCIIPGALALLNGFILIFYPLS 455
Cdd:cd17452 354 FTKLSAGIALGISTLSLEFAGYETGAcKQPESVVLTLKLLIGAAPTCMILIGLCILMFYPIT 415
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
37-415 |
1.88e-09 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 59.36 E-value: 1.88e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 37 FLFYYYTDVFGLNPAAIGTMYLVANFWDAVNDPLMGAIADRVqtakgKYRPFLLWFAIPYGLAGYAIFANPDFSEVgkla 116
Cdd:cd06174 17 PLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRF-----GRRPVLLLGLLLFALGALLFAFAPSFWLL---- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 117 yaYTTFIVFKMIYTAINVPYSALMGVITPDANDRMALSTFRFLGAFGGgfIVSLLVRPLVKLFGGDDEVLGFQLTMAVFG 196
Cdd:cd06174 88 --LLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGG--ILGPLLGGILASSLGFGWRAVFLIAAALAL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 197 VASILMFLITYASTRERVKPQAEEKDMSVKEDLKLLCRNLPWLIMIGAAVCtlanvavrgavtihyfkYYVGNSAEAVFS 276
Cdd:cd06174 164 LAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFL-----------------VNLAYYSFSTLL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 277 IGQSGTAFFLEFDATTIFMSTGMIAFIIGVAFTGIIGRTFGKRNALATLTLLNAATIIGFYFIPPeaTATMYVVNLLANL 356
Cdd:cd06174 227 PLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAP--SLLLLLLLLLLLG 304
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1519714020 357 LAGPTPALVWALYTDVAdygewkFGRRATGLVFSAAMFAQKMGLTIGGAASGWLLAGFG 415
Cdd:cd06174 305 FGLGGLLPLSFALIAEL------FPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF 357
|
|
| MFS_NLS1_MFSD2A |
cd17451 |
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of ... |
17-242 |
8.57e-08 |
|
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of transporters; Sodium-dependent lysophosphatidylcholine (LPC) symporter 1 (NLS1) is also called major facilitator superfamily domain-containing protein 2A (MFSD2A). NLS1/MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. It also transports the essential omega-3 fatty acid docosahexaenoic acid (DHA), which is essential for normal brain growth and cognitive function, in the form of LPC into the brain across the blood-brain barrier. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. NLS1/MFSD2A belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341009 Cd Length: 419 Bit Score: 54.43 E-value: 8.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 17 KVGYGLGDMASNLYFQFFNLFLFYYYTDVFGLNPAAIGTMYLVANFWDAVNDPLMGAIADRVQ-TAKGKYRPFLLWFAIP 95
Cdd:cd17451 1 KLCYAIGGAPYQITGCALGFFLQIYLLDVAQLDPFYASIILFVGRAWDAITDPTVGFFVSKSPwTRFGRLMPWIIFSTPF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 96 YGLAGYAIFANPDFSeVGKLAYAYTTFIVFKMIYTAINVPYSALMGVITPDANDRMALSTFRF----LGAFGGGFIVSLL 171
Cdd:cd17451 81 AVLSYFLIWFVPDFS-QGKVMWYLLFYCLFQTLQTCFHVPYSALTMFISTEQKERDSATAYRMtvevLGTVLGTAIQGQI 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1519714020 172 VrplvklfggddEVLGFQLTMAVFGVASILMFLITYASTRERVKP--QAEEKDMSVKEDLKLLCRNLPWLIMI 242
Cdd:cd17451 160 V-----------GMAAYMIAAGVICAIYVLCAIILFLGVREQREPceLKSQKPVSFFKGLKLVMSHGPYIKLI 221
|
|
| MFS_MFSD2 |
cd17392 |
Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator ... |
17-174 |
2.31e-07 |
|
Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator superfamily domain-containing protein 2 (MFSD2) subfamily is composed of two vertebrate members, MFSD2A amd MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD2 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340950 Cd Length: 446 Bit Score: 52.86 E-value: 2.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 17 KVGYGLGDMASNLYFQFFNLFLFYYYTDVFGLNPAAIGTMYLVANFWDAVNDPLMGAIADRVQ-TAKGKYRPFLLwFAIP 95
Cdd:cd17392 1 KLCYAIGGAPYQMTSSATGFFLQIFLLDVAQMGAFSVSLILFVGRVWDAVTDPLVGYFISRSQrTGIGRLMPWIV-FSTP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 96 YG-LAGYAIFANPDFSEVGklAYAYTTF-IVFKMIYTAINVPYSALMGVITPDANDRMALSTFR--------FLGAFGGG 165
Cdd:cd17392 80 LIiLAYFFLWFLPPFTSLS--GLWYLTFyCLFETFMTCFHVPYSALTMFLGGCQRERDSATAYRmtvevfgtLMGATIQG 157
|
....*....
gi 1519714020 166 FIVSLLVRP 174
Cdd:cd17392 158 QIVGVAHRP 166
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
41-370 |
1.25e-06 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 50.54 E-value: 1.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 41 YYTDVFGLNPAAIGTMYL-----VANFWDAVNDPLMGAIADRvqtaKGKYRPFLLWFAIPYGLAGYAIFanpdFSEVGKL 115
Cdd:COG2270 37 YFTSVAALGDPAAATALWgyalaIAGLLVALLAPVLGAIADR----SGRKKPFLAFFTLLGVLATAALF----FVAPGGL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 116 AYAYTTFIVFKMIYTAINVPYSALMGVITPDAN-DRmaLSTFRF-LGAFGGG--FIVSLLVRPLVKLFGGDDEVLGFQLT 191
Cdd:COG2270 109 WLGLLLFVLANIGFEGSLVFYNAFLPDIATPEEiGR--VSGLGWaLGYLGGVllLLINLALFLKPEAFGLPDAGEAVRIS 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 192 M----AVFGVASILMFLItyasTRERVKPQAEEKDMSVKEDLKLLCRnlpwlimigaavcTLANVAVRGAVtihyFKYYV 267
Cdd:COG2270 187 FlltaLWWLLFALPLFLF----LPERPRPGPAPPRGAVRAGFRELRR-------------TLRELRRYRDL----LRFLL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 268 gnsAEAVFSIG-QSGTAFFLEFDATTI-FMSTGMIAFIIGVAFTGIIG--------RTFGKRNALATLTLLNAATIIGFY 337
Cdd:COG2270 246 ---AYFFYRDGvQTVIAFAGIYAAGVLgFSTTELIVFGLLVQIVAALGallfgrldDRIGPKRVILVSLVIWIVVCLAAY 322
|
330 340 350
....*....|....*....|....*....|...
gi 1519714020 338 FIPPEatATMYVVNLLANLLAGPTPALVWALYT 370
Cdd:COG2270 323 FLTTA--LAFWILGLLIGLVMGGIQALSRSLLA 353
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
46-237 |
6.72e-05 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 44.93 E-value: 6.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 46 FGLNPAAIGTMYLVANFWDAVNDPLMGAIADRVQTAKGKYRPFLLwFAIPYGLAGYAIFANPDFSEVGKLAYAYTTFIVF 125
Cdd:cd17313 29 LGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGRRRPFIL-VGAPLAALGLILIPNAADIGLALGDGPRTWALVL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 126 KMIYTAI-----NV---PYSALMGVITPDANDRMALSTFRFLGAFGGgfIVSLLVRPLVKLFGGDDEVLGFQLTMAvFGV 197
Cdd:cd17313 108 FVLGIVLldfamNVcqgPVRALLPDLVPPEQRSKANGIINFMGGLGG--VLGYLLGAILWDHNWFGFALGGNLKVP-FYI 184
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1519714020 198 ASILM---FLITYASTRER-VKPQAEEKDMS-----VKEDLKLLCRNLP 237
Cdd:cd17313 185 GAIILlvcVLVTLFFVKEPpLSPEAGEHSENpslgeVLKSLLKLLKIMP 233
|
|
| MFS_MFSD12 |
cd17491 |
Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily ... |
17-220 |
1.05e-04 |
|
Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily domain-containing protein 12 (MFSD12) protein subfamily includes a group of uncharacterized proteins similar to human MFSD2. MFSD2 is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD12 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341044 Cd Length: 438 Bit Score: 44.56 E-value: 1.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 17 KVGYGLGDMASNLYFQFFNLFLFYYYTDVFGLNPAAIGTMYLVANFWDAVNDPLMGAIADRVqTAKGKYRP--------- 87
Cdd:cd17491 1 RIAYGVGHVLNDLCASMWFTYLLVYFHLVLGFSSALAGILLLIGQVADAISTPLVGYESDRT-NGCGKYGRrkswhligt 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 88 FLLWFAIPYgLAGYAIFANPDFSEVGKLAYaYTTFIV-FKMIYTAINVPYSALMGVITPDANDRMALSTFRFLGAFGGGF 166
Cdd:cd17491 80 ICVLLSFPF-IFNPCLGCSDSTSEWAKLVY-YGPFIIiFQFGWAAVQISHLSLIPELTSDEHERVELTALRYAFTVIANI 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1519714020 167 IVSLLVRPLVKLFGGDDEVLGFQLTMAVFGVAS-------ILMFLITYASTRERVKPQAEE 220
Cdd:cd17491 158 TVYLIAWLLLQQSSGDSVNPTSAQDLPIFRNLSlivvgigFLFSLLFHLGTKEPRPPTDLS 218
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
22-444 |
4.06e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 42.60 E-value: 4.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 22 LGDMASNLYFQFFNLFLFYYYTDVFGLNPAAIGTMYLVANFWDAVNDPLMGAIADRVQtakgkYRPFLLW--FAIPYGLA 99
Cdd:cd17329 6 IGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFG-----RKPVMLAglLLRALGFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 100 GYAIFANPdfsevgklayaYTTFIVFKMI---YTAINVPYSALMGVITPDANDRMALSTFRFLGAFG---GGFIVSLLVr 173
Cdd:cd17329 81 LLGFAHSP-----------WLFAIALVLTgfgGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGvaiGPLLGGLLL- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 174 plvklfggddeVLGFQLTMAVFGVASILMFLITYASTRERVKPQAEEKDMSVKEDLKLLCRNLP-WLIMIGAAVCTLANV 252
Cdd:cd17329 149 -----------LYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAfLLFLLASFLISLIYF 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 253 AVRGAVTIHYFKyyvgnsaeaVFSIGQSGTAFFLefdattifmstgMIAFIIGVAFTGIIGRTFGKRNALATLTLLNAAT 332
Cdd:cd17329 218 QLESTLPVYVVE---------ILGLGESLLGLLL------------ALNALLIVLLQFPVARLVERFRLRKILMIGILLF 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 333 IIGFYFIppeATATMYVVNLLANLLAGPTPALVW-ALYTDVADYGEwkfgRRATGLVFSAAMFAQKMGLTIGGAASGWLL 411
Cdd:cd17329 277 AIGFAVL---AFANTLAVLILAMIVLTLGEMLVFpAVQTLVAALAP----PDKRGSYMGFYALAWGLGRAIGPLVGGLLL 349
|
410 420 430
....*....|....*....|....*....|...
gi 1519714020 412 AGFGfvanqdqtPEALMGIRIMFCIIPGALALL 444
Cdd:cd17329 350 DLLG--------PGLPWLILAALGLIAAALLLG 374
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
149-415 |
1.68e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 40.63 E-value: 1.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 149 DRMALSTFRFLGAFGGGFIVSLLVRPLVKlfggddEVLGFQLTMAVFGVASILMFLITYASTRERVKPQAEEKDMSVKED 228
Cdd:COG2223 125 DRRGLALGLAAGGGNLGAAVAAFLAPLLI------AAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQ 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 229 LKLLCRNLPWLIMIGAAVCTLANVAVRGAVTIhYFKYYVGNSAEAVfsigqsgtafflefdatTIFMSTGMIAFIIGVAF 308
Cdd:COG2223 199 LEALRDPRFWLLSLLYFGTFGSFIGFSSWLPP-YLVDQFGLSAATA-----------------GLLAALFALLGALGRPL 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 309 TGIIGRTFGKRNALATLTLLNAATIIGFYFIPPEATATMYVVNLLAnLLAGPTPALVWALytdVADYgewkFGRRATGLV 388
Cdd:COG2223 261 GGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLG-LALGGGNGAVFAL---VPDI----FPTKNAGAV 332
|
250 260
....*....|....*....|....*..
gi 1519714020 389 FSAAMFAQKMGLTIGGAASGWLLAGFG 415
Cdd:COG2223 333 YGLVGAAGGLGGFLGPLLFGALLDATG 359
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
44-345 |
1.85e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 40.61 E-value: 1.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 44 DVFGLNPAAIGTMYLVANFWDAVNDPLMGAIADRVqtakgKYRPFLLWFAIPYGLAGYAIFANPDFSEVgkLAYAYTTFI 123
Cdd:COG0738 36 DAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRF-----GYKRGLLLGLLLMALGLLLFALAPSYPLL--LLALFLLGL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 124 VFKMIYTAINvPYSALMGVITpdANDRMALSTFRF-LGAFGGGFIVSLLVrplvkLFGGDDEVlgfQLTMAVFGVASILM 202
Cdd:COG0738 109 GLGLLDVAAN-PYVAALGPET--AASRLNLLHAFFsLGALLGPLLGGLLI-----LLGLSLSW---HLPYLILAVLLLLL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 203 FLITYASTRERVKPQAEEKDMSVKEDLKLLCRNLPWLIMIGAAVCTLANVAVrGAVTIHYFKYYVGNSAEAVfsigqsgt 282
Cdd:COG0738 178 ALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAI-GDWLPLYLKDVLGLSEATA-------- 248
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1519714020 283 afflefdatTIFMSTGMIAFIIGVAFTGIIGRTFGKRNALATLTLLNAATIIGFYFIPPEATA 345
Cdd:COG0738 249 ---------ALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLA 302
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
37-246 |
2.31e-03 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 40.26 E-value: 2.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 37 FLFYYYTDVfGLNPAAIGTMYLVANFWDAVNDPLMGAIADRVqtakGKYRPFLLWFAIPYGLAGYAIFANPDfsevgkla 116
Cdd:cd17335 19 FLSVYLKQL-GLSPTQIGILIGIRPFVRFLSAPLWGALADRF----GKRKALLLLSLLAAVLFFLSLFFVAQ-------- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 117 yAYTTFIVFKMIYTAINVPYSALMGVITPD--ANDRMALSTFRFLGAFGGGfIVSLLVRPLVklfggdDEVLGFQLTMAV 194
Cdd:cd17335 86 -IFWLLLLLVILGAFFSAPVVPLVDSITLQylGEERERYGKQRLWGSIGFG-IAALLVGILI------DRSSTYKNYTIA 157
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 1519714020 195 FGVASILMFLITYASTRERVKPQAEEKDMSVKEDLKLLCrNLPWLIMIGAAV 246
Cdd:cd17335 158 FYVFAVLMLLALLLALKFPFRPKHPEPNENTGGLLALLR-NPRVLAFLLVAF 208
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
18-207 |
2.38e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 40.25 E-value: 2.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 18 VGYGLGDMASNLYFQFFNLFLFYYYTDVFGLNPAAIGTMYLVANFWDAVNDPLMGAIADRVqtakGKYRPFLLwfaipyG 97
Cdd:cd17325 202 LALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRI----GRKPLILI------G 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 98 LAGYAIFAnPDFSEVGKLAYAYTTFIVFKMIYTAINVPYSALMGVITPDANDRMALSTFRF---LGAFGGGFIVSLLVrp 174
Cdd:cd17325 272 LLLSAVAL-LLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTafsLGMVLGPLLGGFLY-- 348
|
170 180 190
....*....|....*....|....*....|...
gi 1519714020 175 lvklfggddEVLGFQLTMAVFGVASILMFLITY 207
Cdd:cd17325 349 ---------DAFGFATPFLAAAALLLLAAVLFL 372
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
31-220 |
3.30e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 39.86 E-value: 3.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 31 FQFFNLFLFYYYTDVFGLNPAAIGTMYLVANFWDAVNDPLMGAIADRVqtakGKYRPFLLWFAIpyGLAGYAIFANPDFS 110
Cdd:COG2223 221 FIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRI----GGRRVLLIVFAL--MALGLLLLALALGS 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 111 evgkLAYAYTTFIVFKMIYTAINVPYSALMGVITPDANdRMALSTFRFLGAFGGGFIVSLLVRPLVKLFGgddevlGFQL 190
Cdd:COG2223 295 ----LWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKN-AGAVYGLVGAAGGLGGFLGPLLFGALLDATG------SYTA 363
|
170 180 190
....*....|....*....|....*....|
gi 1519714020 191 TMAVFGVASILMFLITYAsTRERVKPQAEE 220
Cdd:COG2223 364 AFLVFAVLALVALVLTLL-LYRRPRRAAAA 392
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
41-416 |
3.82e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 39.48 E-value: 3.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 41 YYTDVFGLNPAAIGTMYLVANFWDAVNDPLMGAIADRVQtakgkYRPFLLWFAIPYGLAGYAIFanpdfsevgkLAYAYT 120
Cdd:cd17325 21 LYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFG-----RKRLLLLGLLLLAVSTLLFA----------FATSYW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 121 TFIVFKMIY---TAINVPYSALMGVITPDANDRMalstfRFLGAFGGGFIVSLLVRPLvklFGGD-DEVLGFQLTMAVFG 196
Cdd:cd17325 86 QLLLARFLQglaSAAVWPAAMALIADIAPPEERG-----RAMGIFSSAIGLGFLIGPL---LGGLlADALGYRAPFLVCA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 197 VASILMFLITYASTRERVKPQAEEK--DMSVKEDLKLLCRNLPWLIMIGAAVCTLANVAVRGAVTIHYFKYYVGNSAEAV 274
Cdd:cd17325 158 ALALLALVLALLLLPEPRPPPNKRAvsAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQI 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 275 FsigqsgtafflefdattIFMSTGMIAFIIGVAFTGIIGRTFGKRNALATLTLLNAATIIGFYFippeatATMYVVNLLA 354
Cdd:cd17325 238 G-----------------LLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPL------ATSFWLLLLL 294
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1519714020 355 NLLAGPTPALVW-ALYTDVADYgewkFGRRATGLVFSAAMFAQKMGLTIGGAASGWLLAGFGF 416
Cdd:cd17325 295 LALLGLGLGLVFpATLALLADI----VPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGF 353
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
158-415 |
5.04e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 39.18 E-value: 5.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 158 FLGAFGGGFIVSLLVRPLVklfggddEVLGFQLTMAVFG-VASILMFLITYASTRERVKPQAEEKDMSVKED----LKLL 232
Cdd:cd17355 134 TAGGGLGSLVFLPLGAALI-------EAFGWRTALLVLAlLALLVLVPVLLLLRRRPADLALRAYDDASPASpgstLKEA 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 233 CRNLP-WLIMIGAAVCTLANVAVrgavTIHYFKYYVgnsaEAVFSIGQSGTAfflefdattifMSTGMIAFIIGVAFTGI 311
Cdd:cd17355 207 LRSASfWLLALAFFLCGFAVVGL----IVHLVPYLA----DRGISPAAAAVA-----------LALIGLFNIVGRLLSGW 267
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519714020 312 IGRTFGKRNALATLTLLNAATIIGFYFIPPEATAtMYVVNLLANLLAGPTPALVWALYTDvadygewKFGRRATGLVFSA 391
Cdd:cd17355 268 LGDRYSPRRLLAASYALRALGLALLLLLPFPPLA-LLLFAALFGLGWGATVPLTAALAAR-------YFGARSYGTLFGL 339
|
250 260
....*....|....*....|....
gi 1519714020 392 AMFAQKMGLTIGGAASGWLLAGFG 415
Cdd:cd17355 340 VFAPHQLGSALGPWLGGLLYDRTG 363
|
|
| |
