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Conserved domains on  [gi|1519556464|gb|AZB08979|]
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DeoR/GlpR transcriptional regulator [Chryseobacterium sp. G0162]

Protein Classification

DeoR/GlpR family DNA-binding transcription regulator( domain architecture ID 11442564)

DeoR/GlpR family DNA-binding transcription regulator is a helix-turn-helix type transcriptional regulator that may be involved in sugar metabolism

Gene Ontology:  GO:0003700|GO:0003677
PubMed:  15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 7-252 2.59e-111

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


:

Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 320.54  E-value: 2.59e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519556464   7 RHDEILKELDEKGHVLVQDLCEKLNVSSVTIRKDLNYLESLGLLFRNHGGASKQVRYAYEQNVGEKENINVEAKQTIAKA 86
Cdd:COG1349     6 RRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAAAEPPFAERETLNAEEKRAIARA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519556464  87 ALSLIQENDCIILASGTTMHYLARMLMNFGPLTVLTSSLRVAIELCNNPNINVIQLGGEVRKSSTSIVGSISEGILKQFS 166
Cdd:COG1349    86 AASLIEDGDTIFLDAGTTTLALARALPDRRNLTVVTNSLNIANELAERPNIEVILLGGELRPSSGSLVGPLAEEALRRFR 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519556464 167 CNKLFLGVDGIDLEFGISTSNAAEAHLNQVMIECADKTVVLADSSKLNKKGFGKIAALDQVDYLITDDGIAPEDQVRLEE 246
Cdd:COG1349   166 ADKAFLGASGIDAEGGLTTFDEEEAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGPPPELLEALEE 245


                  ....*.
gi 1519556464 247 IGVNVM 252
Cdd:COG1349   246 AGVEVI 251
 
Name Accession Description Interval E-value
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 7-252 2.59e-111

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 320.54  E-value: 2.59e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519556464   7 RHDEILKELDEKGHVLVQDLCEKLNVSSVTIRKDLNYLESLGLLFRNHGGASKQVRYAYEQNVGEKENINVEAKQTIAKA 86
Cdd:COG1349     6 RRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAAAEPPFAERETLNAEEKRAIARA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519556464  87 ALSLIQENDCIILASGTTMHYLARMLMNFGPLTVLTSSLRVAIELCNNPNINVIQLGGEVRKSSTSIVGSISEGILKQFS 166
Cdd:COG1349    86 AASLIEDGDTIFLDAGTTTLALARALPDRRNLTVVTNSLNIANELAERPNIEVILLGGELRPSSGSLVGPLAEEALRRFR 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519556464 167 CNKLFLGVDGIDLEFGISTSNAAEAHLNQVMIECADKTVVLADSSKLNKKGFGKIAALDQVDYLITDDGIAPEDQVRLEE 246
Cdd:COG1349   166 ADKAFLGASGIDAEGGLTTFDEEEAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGPPPELLEALEE 245


                  ....*.
gi 1519556464 247 IGVNVM 252
Cdd:COG1349   246 AGVEVI 251
AgaR NF040755
transcriptional repressor AgaR;
7-252 5.61e-73

transcriptional repressor AgaR;


Pssm-ID: 468715 [Multi-domain]  Cd Length: 256  Bit Score: 223.30  E-value: 5.61e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519556464   7 RHDEILKELDEKGHVLVQDLCEKLNVSSVTIRKDLNYLESLGLLFRNHGGA--SKQVRYAYEQNVGEKENINVEAKQTIA 84
Cdd:NF040755    7 RREQIIQRLRQQGSVQVEDLSALFGVSTVTIRNDLAFLEKQGIAVRAYGGAliNDGFIPGAEPSVEDKSRLNTAVKRLIA 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519556464  85 KAALSLIQENDCIILASGTTMHYLARMLMNFGPLTVLTSSLRVAIELCNNPNINVIQLGGEVRKSSTSIVGSISEGILKQ 164
Cdd:NF040755   87 AAAAELIKPGDRVILDSGTTTYEIARHLKQHQDVVVMTNGLNVANELLEAEGVEVLMTGGHLRRQSLSFYGDQAEQSLQN 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519556464 165 FSCNKLFLGVDGIDLEFGISTSNAAEAHLNQVMIECADKTVVLADSSKLNKKGFGKIAALDQVDYLITDDGIAPEDQVRL 244
Cdd:NF040755  167 YHFDKLFLGVDGFDLERGITTHNEDEARLNRRMCEVAERIIAVTDSSKFGRSSLHKIRDTGRIDTLITDSGIPEEYLQGL 246


                  ....*...
gi 1519556464 245 EEIGVNVM 252
Cdd:NF040755  247 RKLGVEVI 254
DeoRC pfam00455
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive ...
 75-233 2.36e-65

DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site. DeorC senses diverse sugar derivatives such as deoxyribose nucleoside (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR). It can also bind L-ascorbate 6-phosphate, agrocinopines, sn-glycerol 3-phosphate, and sulfoquinovose (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395365  Cd Length: 160  Bit Score: 200.43  E-value: 2.36e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519556464  75 INVEAKQTIAKAALSLIQENDCIILASGTTMHYLARMLMNFGPLTVLTSSLRVAIELCNNPNINVIQLGGEVRKSSTSIV 154
Cdd:pfam00455   1 ENAEEKRRIAKAAASLIEDGDTIFLDAGTTTLELARALPDRRNLTVITNSLNIANELSEKPDIEVILLGGEVRPKTGAFV 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1519556464 155 GSISEGILKQFSCNKLFLGVDGIDLEFGISTSNAAEAHLNQVMIECADKTVVLADSSKLNKKGFGKIAALDQVDYLITD 233
Cdd:pfam00455  81 GPLAEEFLRQFNVDKAFIGANGIDLEGGLTTSDEEEAEVKRAMIEAARRVILLADSSKFGKRAFARFAPLEDIDALITD 159
PRK09802 PRK09802
DeoR family transcriptional regulator;
7-252 6.78e-63

DeoR family transcriptional regulator;


Pssm-ID: 182086 [Multi-domain]  Cd Length: 269  Bit Score: 198.15  E-value: 6.78e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519556464   7 RHDEILKELDEKGHVLVQDLCEKLNVSSVTIRKDLNYLESLGLLFRNHGGAS--KQVRYAYEQNVGEKENINVEAKQTIA 84
Cdd:PRK09802   18 RREQIIQRLRQQGSVQVNDLSALYGVSTVTIRNDLAFLEKQGIAVRAYGGALicDSTTPSVEPSVEDKSALNTAMKRSVA 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519556464  85 KAALSLIQENDCIILASGTTMHYLARMLMNFGPLTVLTSSLRVAIELCNNPNINVIQLGGEVRKSSTSIVGSISEGILKQ 164
Cdd:PRK09802   98 KAAVELIQPGHRVILDSGTTTFEIARLMRKHTDVIAMTNGMNVANALLEAEGVELLMTGGHLRRQSQSFYGDQAEQSLQN 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519556464 165 FSCNKLFLGVDGIDLEFGISTSNAAEAHLNQVMIECADKTVVLADSSKLNKKGFGKIAALDQVDYLITDDGIAPEDQVRL 244
Cdd:PRK09802  178 YHFDMLFLGVDAIDLERGVSTHNEDEARLNRRMCEVAERIIVVTDSSKFNRSSLHKIIDTQRIDMIIVDEGIPADSLEGL 257


                  ....*...
gi 1519556464 245 EEIGVNVM 252
Cdd:PRK09802  258 RKAGVEVI 265
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
7-57 4.59e-15

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 67.25  E-value: 4.59e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1519556464    7 RHDEILKELDEKGHVLVQDLCEKLNVSSVTIRKDLNYLESLGLLFRNHGGA 57
Cdd:smart00420   1 RQQQILELLAQQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHGGA 51
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 23-55 3.43e-04

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 37.81  E-value: 3.43e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1519556464  23 VQDLCEKLNVSSVTIRKDLNYLESLGLLFRNHG 55
Cdd:cd07377    28 ERELAEELGVSRTTVREALRELEAEGLVERRPG 60
 
Name Accession Description Interval E-value
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 7-252 2.59e-111

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 320.54  E-value: 2.59e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519556464   7 RHDEILKELDEKGHVLVQDLCEKLNVSSVTIRKDLNYLESLGLLFRNHGGASKQVRYAYEQNVGEKENINVEAKQTIAKA 86
Cdd:COG1349     6 RRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAAAEPPFAERETLNAEEKRAIARA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519556464  87 ALSLIQENDCIILASGTTMHYLARMLMNFGPLTVLTSSLRVAIELCNNPNINVIQLGGEVRKSSTSIVGSISEGILKQFS 166
Cdd:COG1349    86 AASLIEDGDTIFLDAGTTTLALARALPDRRNLTVVTNSLNIANELAERPNIEVILLGGELRPSSGSLVGPLAEEALRRFR 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519556464 167 CNKLFLGVDGIDLEFGISTSNAAEAHLNQVMIECADKTVVLADSSKLNKKGFGKIAALDQVDYLITDDGIAPEDQVRLEE 246
Cdd:COG1349   166 ADKAFLGASGIDAEGGLTTFDEEEAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGPPPELLEALEE 245


                  ....*.
gi 1519556464 247 IGVNVM 252
Cdd:COG1349   246 AGVEVI 251
AgaR NF040755
transcriptional repressor AgaR;
7-252 5.61e-73

transcriptional repressor AgaR;


Pssm-ID: 468715 [Multi-domain]  Cd Length: 256  Bit Score: 223.30  E-value: 5.61e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519556464   7 RHDEILKELDEKGHVLVQDLCEKLNVSSVTIRKDLNYLESLGLLFRNHGGA--SKQVRYAYEQNVGEKENINVEAKQTIA 84
Cdd:NF040755    7 RREQIIQRLRQQGSVQVEDLSALFGVSTVTIRNDLAFLEKQGIAVRAYGGAliNDGFIPGAEPSVEDKSRLNTAVKRLIA 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519556464  85 KAALSLIQENDCIILASGTTMHYLARMLMNFGPLTVLTSSLRVAIELCNNPNINVIQLGGEVRKSSTSIVGSISEGILKQ 164
Cdd:NF040755   87 AAAAELIKPGDRVILDSGTTTYEIARHLKQHQDVVVMTNGLNVANELLEAEGVEVLMTGGHLRRQSLSFYGDQAEQSLQN 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519556464 165 FSCNKLFLGVDGIDLEFGISTSNAAEAHLNQVMIECADKTVVLADSSKLNKKGFGKIAALDQVDYLITDDGIAPEDQVRL 244
Cdd:NF040755  167 YHFDKLFLGVDGFDLERGITTHNEDEARLNRRMCEVAERIIAVTDSSKFGRSSLHKIRDTGRIDTLITDSGIPEEYLQGL 246


                  ....*...
gi 1519556464 245 EEIGVNVM 252
Cdd:NF040755  247 RKLGVEVI 254
DeoRC pfam00455
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive ...
 75-233 2.36e-65

DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site. DeorC senses diverse sugar derivatives such as deoxyribose nucleoside (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR). It can also bind L-ascorbate 6-phosphate, agrocinopines, sn-glycerol 3-phosphate, and sulfoquinovose (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395365  Cd Length: 160  Bit Score: 200.43  E-value: 2.36e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519556464  75 INVEAKQTIAKAALSLIQENDCIILASGTTMHYLARMLMNFGPLTVLTSSLRVAIELCNNPNINVIQLGGEVRKSSTSIV 154
Cdd:pfam00455   1 ENAEEKRRIAKAAASLIEDGDTIFLDAGTTTLELARALPDRRNLTVITNSLNIANELSEKPDIEVILLGGEVRPKTGAFV 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1519556464 155 GSISEGILKQFSCNKLFLGVDGIDLEFGISTSNAAEAHLNQVMIECADKTVVLADSSKLNKKGFGKIAALDQVDYLITD 233
Cdd:pfam00455  81 GPLAEEFLRQFNVDKAFIGANGIDLEGGLTTSDEEEAEVKRAMIEAARRVILLADSSKFGKRAFARFAPLEDIDALITD 159
PRK09802 PRK09802
DeoR family transcriptional regulator;
7-252 6.78e-63

DeoR family transcriptional regulator;


Pssm-ID: 182086 [Multi-domain]  Cd Length: 269  Bit Score: 198.15  E-value: 6.78e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519556464   7 RHDEILKELDEKGHVLVQDLCEKLNVSSVTIRKDLNYLESLGLLFRNHGGAS--KQVRYAYEQNVGEKENINVEAKQTIA 84
Cdd:PRK09802   18 RREQIIQRLRQQGSVQVNDLSALYGVSTVTIRNDLAFLEKQGIAVRAYGGALicDSTTPSVEPSVEDKSALNTAMKRSVA 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519556464  85 KAALSLIQENDCIILASGTTMHYLARMLMNFGPLTVLTSSLRVAIELCNNPNINVIQLGGEVRKSSTSIVGSISEGILKQ 164
Cdd:PRK09802   98 KAAVELIQPGHRVILDSGTTTFEIARLMRKHTDVIAMTNGMNVANALLEAEGVELLMTGGHLRRQSQSFYGDQAEQSLQN 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519556464 165 FSCNKLFLGVDGIDLEFGISTSNAAEAHLNQVMIECADKTVVLADSSKLNKKGFGKIAALDQVDYLITDDGIAPEDQVRL 244
Cdd:PRK09802  178 YHFDMLFLGVDAIDLERGVSTHNEDEARLNRRMCEVAERIIVVTDSSKFNRSSLHKIIDTQRIDMIIVDEGIPADSLEGL 257


                  ....*...
gi 1519556464 245 EEIGVNVM 252
Cdd:PRK09802  258 RKAGVEVI 265
srlR PRK10434
DNA-binding transcriptional repressor;
3-252 6.25e-58

DNA-binding transcriptional repressor;


Pssm-ID: 182457 [Multi-domain]  Cd Length: 256  Bit Score: 184.89  E-value: 6.25e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519556464   3 KLIPRHDEILKELDEKGHVLVQDLCEKLNVSSVTIRKDLNYLESLGLLFRNHGGASKQvRYAYEQNVGEKENINVEAKQT 82
Cdd:PRK10434    2 KPRQRQAAILEYLQKQGKTSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGVVLN-KEESDPPIDHKTLINTHKKEL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519556464  83 IAKAALSLIQENDCIILASGTTMHYLARMLMNFGPLTVLTSSLRV---AIELCNNPNInvIQLGGEVRKSSTSIVGSISE 159
Cdd:PRK10434   81 IAEAAVSLIHDGDSIILDAGSTVLQMVPLLSRFNNITVMTNSLHIvnaLSELDNEQTI--LMPGGTFRKKSASFHGQLAE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519556464 160 GILKQFSCNKLFLGVDGIDLEFGISTSNaaEAH-LNQVMIECADKTVVLADSSKLNKKGFGKIAALDQVDYLITDDGIAP 238
Cdd:PRK10434  159 NAFEHFTFDKLFIGTDGIDLNAGVTTFN--EVYtVSKAMCNAAREIILMADSSKFGRKSPNVVCSLEKVDKLITDAGIDP 236

                         250
                  ....*....|....
gi 1519556464 239 EDQVRLEEIGVNVM 252
Cdd:PRK10434  237 AFRQALEEKGIEVI 250
PRK13509 PRK13509
HTH-type transcriptional regulator UlaR;
7-252 6.33e-33

HTH-type transcriptional regulator UlaR;


Pssm-ID: 184100 [Multi-domain]  Cd Length: 251  Bit Score: 120.11  E-value: 6.33e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519556464   7 RHDEILKELDEKGHVLVQDLCEKLNVSSVTIRKDLNYLESLGLLFRNHGGA---SKQVRYAYEQNVGEKENInvEAKQTI 83
Cdd:PRK13509    6 RHQILLELLAQLGFVTVEKVIERLGISPATARRDINKLDESGKLKKVRNGAeaiTQQRPRWTPMNIHQAQNH--DEKVRI 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519556464  84 AKAALSLIQENDCIILASGTTMHYLARMLMNfGPLTVLTSSLRVAIELCNNPNINVIQLGGEVRKSStSIVGSISEGILK 163
Cdd:PRK13509   84 AKAASQLCNPGESVVINCGSTAFLLGRELCG-KPVQIITNYLPLANYLIDQEHDSVIIMGGQYNKSQ-SITLSPQGSENS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519556464 164 QFSCNKLFLGVDGIDLEfGISTSNAAEAHLNQVMIECADKTVVLADSSKLNKKGFGKIAALDQVDYLITDDGIAPEDQVR 243
Cdd:PRK13509  162 LYAGHWMFTSGKGLTAD-GLYKTDMLTAMAEQKMLSVVGKLVVLVDSSKIGERAGMLFSRADQIDMLITGKNADPEVLQQ 240


                  ....*....
gi 1519556464 244 LEEIGVNVM 252
Cdd:PRK13509  241 LEAQGVSIL 249
PRK10906 PRK10906
DeoR/GlpR family transcriptional regulator;
3-233 1.23e-28

DeoR/GlpR family transcriptional regulator;


Pssm-ID: 182827 [Multi-domain]  Cd Length: 252  Bit Score: 108.79  E-value: 1.23e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519556464   3 KLIPRHDEILKELDEKGHVLVQDLCEKLNVSSVTIRKDLNYLESLGLLFRNHGGA---SKQVRYAYEqnvgEKENINVEA 79
Cdd:PRK10906    2 KQTQRHDAIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNDLAEQNKILRHHGGAalpSSSVNTPWH----DRKATQTEE 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519556464  80 KQTIAKAALSLIQENDCIILASGTTMHYLARMLMNFGPLTVLTSSLRVAIELCNNPNINVIQLGGEVRKSSTSIVGSISE 159
Cdd:PRK10906   78 KERIARKVASQIPNGATLFIDIGTTPEAVAHALLNHSNLRIVTNNLNVANTLMAKEDFRIILAGGELRSRDGGIIGEATL 157

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1519556464 160 GILKQFSCNKLFLGVDGIDLEFGISTSNAAEAHLNQVMIECADKTVVLADSSKLNKKGFGKIAALDQVDYLITD 233
Cdd:PRK10906  158 DFISQFRLDFGILGISGIDSDGSLLEFDYHEVRTKRAIIENSRHVMLVVDHSKFGRNAMVNMGSISMVDAVYTD 231
PRK10411 PRK10411
L-fucose operon activator;
7-233 4.86e-27

L-fucose operon activator;


Pssm-ID: 236684 [Multi-domain]  Cd Length: 240  Bit Score: 104.50  E-value: 4.86e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519556464   7 RHDEILKELDEKGHVLVQDLCEKLNVSSVTIRKDLNYLESLGLLFRNHGGAsKQVRyAYEQNVGEKENINVEA----KQT 82
Cdd:PRK10411    5 RQQAIVDLLLNHTSLTTEALAEQLNVSKETIRRDLNELQTQGKILRNHGRA-KYIH-RQNQDSGDPFHIRLKShyahKAD 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519556464  83 IAKAALSLIQENDCIILASGTTMHYLARMLMNFgPLTVLTSSLRVAIELCNNPNINVIQLGGEVRKSSTSIVGSISEGIL 162
Cdd:PRK10411   83 IAREALAWIEEGMVIALDASSTCWYLARQLPDI-NIQVFTNSHPICQELGKRERIQLISSGGTLERKYGCYVNPSLISQL 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1519556464 163 KQFSCNKLFLGVDGIDLEFGISTSNAAEAHLNQVMIECADKTVVLADSSKLNKKGFGKIAALDQVDYLITD 233
Cdd:PRK10411  162 KSLEIDLFIFSCEGIDSSGALWDSNAINADYKSMLLKRAAQSLLLIDKSKFNRSGEARIGHLDEVTHIISD 232
PRK10681 PRK10681
DNA-binding transcriptional repressor DeoR; Provisional
 12-241 1.54e-18

DNA-binding transcriptional repressor DeoR; Provisional


Pssm-ID: 182644 [Multi-domain]  Cd Length: 252  Bit Score: 82.05  E-value: 1.54e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519556464  12 LKELDeKGHVlvQDLCEKLNVSSVTIRKDLNYLE-SLGLLfrnhGG-ASKQVRYAYEQNVGEKENINVEAKQTIAKAALS 89
Cdd:PRK10681   16 LKRSD-KLHL--KDAAALLGVSEMTIRRDLNAHSaPVVLL----GGyIVLEPRSASHYLLSDQKSRLVEEKRRAAQLAAT 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519556464  90 LIQENDCIILASGTTMHYLARMLMNFGPLTVLTSSLRVAIELCNNPNINVIQLGGEVrKSSTSIVGSIS-EGILKQFSCN 168
Cdd:PRK10681   89 LVEPNQTLFFDCGTTTPWIIEAIDNELPFTAVCYSLNTFLALQEKPHCRAILCGGEF-HASNAIFKPLDfQQTLDNICPD 167

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1519556464 169 KLFLGVDGIDLEFGISTSNAAEAHLNQVMIECADKTVVLADSSKLNKKGFGKIAALDQVDYLITDdgIAPEDQ 241
Cdd:PRK10681  168 IAFYSAAGVHVSKGATCFNLEELPVKHWAMAMAQKHVLVVDHSKFGKVRPARMGDLTRFDTVVSD--RCPDDE 238
HTH_DeoR pfam08220
DeoR-like helix-turn-helix domain;
7-57 2.90e-15

DeoR-like helix-turn-helix domain;


Pssm-ID: 285436 [Multi-domain]  Cd Length: 57  Bit Score: 68.06  E-value: 2.90e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1519556464   7 RHDEILKELDEKGHVLVQDLCEKLNVSSVTIRKDLNYLESLGLLFRNHGGA 57
Cdd:pfam08220   1 RIQQILELLKQQGTLSVEELAELLGVSEMTIRRDLNELEEQGLLTRTHGGA 51
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
7-57 4.59e-15

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 67.25  E-value: 4.59e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1519556464    7 RHDEILKELDEKGHVLVQDLCEKLNVSSVTIRKDLNYLESLGLLFRNHGGA 57
Cdd:smart00420   1 RQQQILELLAQQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHGGA 51
PRK05472 PRK05472
redox-sensing transcriptional repressor Rex; Provisional
 11-48 2.01e-05

redox-sensing transcriptional repressor Rex; Provisional


Pssm-ID: 235486 [Multi-domain]  Cd Length: 213  Bit Score: 44.34  E-value: 2.01e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1519556464  11 ILKELDEKGHVLV--QDLCEKLNVSSVTIRKDLNYLESLG 48
Cdd:PRK05472   21 YLKELKEEGVERVssKELAEALGVDSAQIRKDLSYFGEFG 60
HTH_11 pfam08279
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.
 11-49 4.87e-05

HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.


Pssm-ID: 429896 [Multi-domain]  Cd Length: 52  Bit Score: 40.11  E-value: 4.87e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1519556464  11 ILKEL-DEKGHVLVQDLCEKLNVSSVTIRKDLNYLESLGL 49
Cdd:pfam08279   3 ILQLLlEARGPISGQELAEKLGVSRRTIRRDIKILEELGV 42
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
25-75 1.18e-04

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 42.16  E-value: 1.18e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1519556464  25 DLCEKLNVSSVTIRKDLNYLESLGLLFRNHG-G---ASKQVRYAYEQNVGEKENI 75
Cdd:COG2188    34 ELAEEFGVSRMTVRKALDELVEEGLLERRQGrGtfvAEPKIEYPLSRLTSFTEEL 88
Put_DNA-bind_N pfam06971
Putative DNA-binding protein N-terminus; This family represents the N-terminus (approximately ...
 11-42 2.07e-04

Putative DNA-binding protein N-terminus; This family represents the N-terminus (approximately 50 residues) of a number of putative bacterial DNA-binding proteins.


Pssm-ID: 429222 [Multi-domain]  Cd Length: 49  Bit Score: 38.20  E-value: 2.07e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1519556464  11 ILKELDEKGHVLV--QDLCEKLNVSSVTIRKDLN 42
Cdd:pfam06971  16 YLEELEEEGVERIssTELAEALGVTAAQVRKDLS 49
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 23-55 3.43e-04

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 37.81  E-value: 3.43e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1519556464  23 VQDLCEKLNVSSVTIRKDLNYLESLGLLFRNHG 55
Cdd:cd07377    28 ERELAEELGVSRTTVREALRELEAEGLVERRPG 60
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 23-57 5.38e-04

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 37.21  E-value: 5.38e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1519556464  23 VQDLCEKLNVSSVTIRKDLNYLESLGLLFRNHGGA 57
Cdd:pfam00392  27 ERELAAEFGVSRTTVREALRRLEAEGLVERRQGRG 61
YobV COG2378
Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains ...
 1-48 1.06e-03

Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains [Transcription];


Pssm-ID: 441945 [Multi-domain]  Cd Length: 314  Bit Score: 39.68  E-value: 1.06e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1519556464   1 MEKLIpRHDEILKELDEKGHVLVQDLCEKLNVSSVTIRKDLNYLESLG 48
Cdd:COG2378     1 MSRLE-RLLALLQLLQSRRGVTAAELAERLEVSERTIYRDIDALRELG 47
CasRa_I-A cd09655
CRISPR/Cas system-associated transcriptional regulator CasRa; CRISPR (Clustered Regularly ...
 1-50 3.62e-03

CRISPR/Cas system-associated transcriptional regulator CasRa; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Predicted transcriptional regulator of CRISPR/Cas system


Pssm-ID: 187786 [Multi-domain]  Cd Length: 198  Bit Score: 37.36  E-value: 3.62e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1519556464   1 MEKLIPRHDEILKELDEKGHVLVQDLCEKLNVSSVTIRKDLNYLESLGLL 50
Cdd:cd09655   134 LAGLSREELKILEVLKAKGEKSVKNIAKKLGKSLSTISRHLRELEKKGLV 183
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
23-58 4.05e-03

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 34.86  E-value: 4.05e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1519556464   23 VQDLCEKLNVSSVTIRKDLNYLESLGLLFRNHGGAS 58
Cdd:smart00345  23 ERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGT 58
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
6-50 8.14e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 36.44  E-value: 8.14e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1519556464   6 PRHDEILKELDEKGHVLVQDLCEKLNVSSVTIRKDLNYLESLGLL 50
Cdd:COG2345    13 PTRRRILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLV 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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