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Conserved domains on  [gi|151946690|gb|EDN64911|]
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MAL-activator protein [Saccharomyces cerevisiae YJM789]

Protein Classification

Zn(II)2Cys6 transcription factor( domain architecture ID 10637801)

Zn(II)2Cys6 transcription factor domain-containing proteins form a subclass of zinc finger proteins found exclusively in fungi

Gene Ontology:  GO:0008270|GO:0003700
PubMed:  9290251|16959962

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GAL4 smart00066
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ...
 4-43 2.18e-10

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.


:

Pssm-ID: 214501 [Multi-domain]  Cd Length: 43  Bit Score: 55.83  E-value: 2.18e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 151946690     4 AKQACDCCRVRRVKCDRNKP-CNRCIQRNLNCTYLQPLKKR 43
Cdd:smart00066   3 VSKACDRCRKRKIKCDGKKPpCSNCIKLGLECTYSDSKKRK 43
fungal_TF_MHR cd12148
fungal transcription factor regulatory middle homology region; This domain is present in the ...
 79-350 4.79e-10

fungal transcription factor regulatory middle homology region; This domain is present in the large family of fungal zinc cluster transcription factors that contain an N-terminal GAL4-like C6 zinc binuclear cluster DNA-binding domain. Examples of members of this large fungal group are the following Saccharomyces cerevisiae transcription factors, GAL4, STB5, DAL81, CAT8, RDR1, HAL9, PUT3, PPR1, ASG1, RSF2, PIP2, as well as the C-terminal domain of the Cep3, a subunit of the yeast centromere-binding factor 3. It has been suggested that this region plays a regulatory role.


:

Pssm-ID: 213391  Cd Length: 410  Bit Score: 61.31  E-value: 4.79e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946690  79 PKNLIDQCLRLYHDNLYVIWPMLSYDDLHKLLEEKYDDR--------CAYWFLVSLSAATLSDLQIEIEYEEGvtfTGEQ 150
Cdd:cd12148    2 PREVADRLLDLYFENVHPLFPILHRPTFLRDLESLYSDPsslspaslALLLAVLALAALSLPDSELRGESRRS---LAER 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946690 151 LCTLCMLSRQFFDDLSNSdIFRIMTYYCLHRCYAQFADTRTSYRLSCEAVGLIKIAGFHREETYE-FLPFGEQQLRRKVY 229
Cdd:cd12148   79 YYEAARQLLDLALFLPPS-LETLQALLLLALYLLGTGDPSSAWLLLGLAIRLAQSLGLHRDPSSLpGLSPFERELRRRLW 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946690 230 YLLLMTERFYAVYIKCVTSL-DATIAPPLPEVVTDPRLSLES--------------FLEVIRVFTIPGKCFYDALATNCV 294
Cdd:cd12148  158 WSLYILDRLLSLSLGRPPSIsDEDIDVPLPSNEDDELSPSSSpppppseeptslsfFIALIRLARILGRILRLLYSPRAS 237

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 151946690 295 DDSCTEDSLKRIWNELHTTSLDIePWSYGYIDFLFSRHWVRTLAWKLVLHMKGMRM 350
Cdd:cd12148  238 SPEDSLETILELDAELEEWRASL-PPELRLDSSSLESPSLLPQRLLLHLLYHLLLI 292
 
Name Accession Description Interval E-value
GAL4 smart00066
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ...
 4-43 2.18e-10

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.


Pssm-ID: 214501 [Multi-domain]  Cd Length: 43  Bit Score: 55.83  E-value: 2.18e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 151946690     4 AKQACDCCRVRRVKCDRNKP-CNRCIQRNLNCTYLQPLKKR 43
Cdd:smart00066   3 VSKACDRCRKRKIKCDGKKPpCSNCIKLGLECTYSDSKKRK 43
Zn_clus pfam00172
Fungal Zn(2)-Cys(6) binuclear cluster domain;
6-43 2.44e-10

Fungal Zn(2)-Cys(6) binuclear cluster domain;


Pssm-ID: 395120 [Multi-domain]  Cd Length: 39  Bit Score: 55.38  E-value: 2.44e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 151946690    6 QACDCCRVRRVKCDRNKP-CNRCIQRNLNCTYLQPLKKR 43
Cdd:pfam00172   1 TACDNCRKRKVKCDGKKPaCSRCIKNGLECTYSRKSKKS 39
fungal_TF_MHR cd12148
fungal transcription factor regulatory middle homology region; This domain is present in the ...
 79-350 4.79e-10

fungal transcription factor regulatory middle homology region; This domain is present in the large family of fungal zinc cluster transcription factors that contain an N-terminal GAL4-like C6 zinc binuclear cluster DNA-binding domain. Examples of members of this large fungal group are the following Saccharomyces cerevisiae transcription factors, GAL4, STB5, DAL81, CAT8, RDR1, HAL9, PUT3, PPR1, ASG1, RSF2, PIP2, as well as the C-terminal domain of the Cep3, a subunit of the yeast centromere-binding factor 3. It has been suggested that this region plays a regulatory role.


Pssm-ID: 213391  Cd Length: 410  Bit Score: 61.31  E-value: 4.79e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946690  79 PKNLIDQCLRLYHDNLYVIWPMLSYDDLHKLLEEKYDDR--------CAYWFLVSLSAATLSDLQIEIEYEEGvtfTGEQ 150
Cdd:cd12148    2 PREVADRLLDLYFENVHPLFPILHRPTFLRDLESLYSDPsslspaslALLLAVLALAALSLPDSELRGESRRS---LAER 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946690 151 LCTLCMLSRQFFDDLSNSdIFRIMTYYCLHRCYAQFADTRTSYRLSCEAVGLIKIAGFHREETYE-FLPFGEQQLRRKVY 229
Cdd:cd12148   79 YYEAARQLLDLALFLPPS-LETLQALLLLALYLLGTGDPSSAWLLLGLAIRLAQSLGLHRDPSSLpGLSPFERELRRRLW 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946690 230 YLLLMTERFYAVYIKCVTSL-DATIAPPLPEVVTDPRLSLES--------------FLEVIRVFTIPGKCFYDALATNCV 294
Cdd:cd12148  158 WSLYILDRLLSLSLGRPPSIsDEDIDVPLPSNEDDELSPSSSpppppseeptslsfFIALIRLARILGRILRLLYSPRAS 237

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 151946690 295 DDSCTEDSLKRIWNELHTTSLDIePWSYGYIDFLFSRHWVRTLAWKLVLHMKGMRM 350
Cdd:cd12148  238 SPEDSLETILELDAELEEWRASL-PPELRLDSSSLESPSLLPQRLLLHLLYHLLLI 292
GAL4 cd00067
GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like ...
 4-36 1.01e-09

GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations


Pssm-ID: 238023 [Multi-domain]  Cd Length: 36  Bit Score: 53.44  E-value: 1.01e-09
                         10        20        30
                 ....*....|....*....|....*....|....
gi 151946690   4 AKQACDCCRVRRVKCDRNK-PCNRCIQRNLNCTY 36
Cdd:cd00067    2 VRRACDRCRRRKIKCDGEKpPCSNCIKLGLECTY 35
Fungal_trans pfam04082
Fungal specific transcription factor domain; This domain is found in a number of fungal ...
 173-311 1.30e-03

Fungal specific transcription factor domain; This domain is found in a number of fungal transcription factors including transcriptional activator xlnR, yeast regulatory protein GAL4, and nicotinate catabolism cluster-specific transcription factor HxnR.


Pssm-ID: 397964  Cd Length: 262  Bit Score: 40.55  E-value: 1.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946690  173 IMTYYCLhrcyaQFADTRTSYRLSCEAVGLIKIAGFHREETYE----FLPFGEQQLRRKVYYLLLMTERFYAVYIKCVTS 248
Cdd:pfam04082  99 LLELYEL-----GTGDRKLHWRYHGLAIRLARSLGLHRDPSYVspswKLWIEEAELRRRLFWACFYLDRLISLILGRPPL 173

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 151946690  249 LDAT-IAPPLPEVVTDprlslESFLEVIRVFTIPGkcfyDALATNCVDDSCTEDSLKRIWNELH 311
Cdd:pfam04082 174 LSDSdIDLPLPCDDDD-----LWESDSADEVTLPL----ISLESKSIKPPLFLIKLSKILSKIL 228
 
Name Accession Description Interval E-value
GAL4 smart00066
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ...
 4-43 2.18e-10

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.


Pssm-ID: 214501 [Multi-domain]  Cd Length: 43  Bit Score: 55.83  E-value: 2.18e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 151946690     4 AKQACDCCRVRRVKCDRNKP-CNRCIQRNLNCTYLQPLKKR 43
Cdd:smart00066   3 VSKACDRCRKRKIKCDGKKPpCSNCIKLGLECTYSDSKKRK 43
Zn_clus pfam00172
Fungal Zn(2)-Cys(6) binuclear cluster domain;
6-43 2.44e-10

Fungal Zn(2)-Cys(6) binuclear cluster domain;


Pssm-ID: 395120 [Multi-domain]  Cd Length: 39  Bit Score: 55.38  E-value: 2.44e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 151946690    6 QACDCCRVRRVKCDRNKP-CNRCIQRNLNCTYLQPLKKR 43
Cdd:pfam00172   1 TACDNCRKRKVKCDGKKPaCSRCIKNGLECTYSRKSKKS 39
fungal_TF_MHR cd12148
fungal transcription factor regulatory middle homology region; This domain is present in the ...
 79-350 4.79e-10

fungal transcription factor regulatory middle homology region; This domain is present in the large family of fungal zinc cluster transcription factors that contain an N-terminal GAL4-like C6 zinc binuclear cluster DNA-binding domain. Examples of members of this large fungal group are the following Saccharomyces cerevisiae transcription factors, GAL4, STB5, DAL81, CAT8, RDR1, HAL9, PUT3, PPR1, ASG1, RSF2, PIP2, as well as the C-terminal domain of the Cep3, a subunit of the yeast centromere-binding factor 3. It has been suggested that this region plays a regulatory role.


Pssm-ID: 213391  Cd Length: 410  Bit Score: 61.31  E-value: 4.79e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946690  79 PKNLIDQCLRLYHDNLYVIWPMLSYDDLHKLLEEKYDDR--------CAYWFLVSLSAATLSDLQIEIEYEEGvtfTGEQ 150
Cdd:cd12148    2 PREVADRLLDLYFENVHPLFPILHRPTFLRDLESLYSDPsslspaslALLLAVLALAALSLPDSELRGESRRS---LAER 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946690 151 LCTLCMLSRQFFDDLSNSdIFRIMTYYCLHRCYAQFADTRTSYRLSCEAVGLIKIAGFHREETYE-FLPFGEQQLRRKVY 229
Cdd:cd12148   79 YYEAARQLLDLALFLPPS-LETLQALLLLALYLLGTGDPSSAWLLLGLAIRLAQSLGLHRDPSSLpGLSPFERELRRRLW 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946690 230 YLLLMTERFYAVYIKCVTSL-DATIAPPLPEVVTDPRLSLES--------------FLEVIRVFTIPGKCFYDALATNCV 294
Cdd:cd12148  158 WSLYILDRLLSLSLGRPPSIsDEDIDVPLPSNEDDELSPSSSpppppseeptslsfFIALIRLARILGRILRLLYSPRAS 237

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 151946690 295 DDSCTEDSLKRIWNELHTTSLDIePWSYGYIDFLFSRHWVRTLAWKLVLHMKGMRM 350
Cdd:cd12148  238 SPEDSLETILELDAELEEWRASL-PPELRLDSSSLESPSLLPQRLLLHLLYHLLLI 292
GAL4 cd00067
GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like ...
 4-36 1.01e-09

GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations


Pssm-ID: 238023 [Multi-domain]  Cd Length: 36  Bit Score: 53.44  E-value: 1.01e-09
                         10        20        30
                 ....*....|....*....|....*....|....
gi 151946690   4 AKQACDCCRVRRVKCDRNK-PCNRCIQRNLNCTY 36
Cdd:cd00067    2 VRRACDRCRRRKIKCDGEKpPCSNCIKLGLECTY 35
Fungal_trans pfam04082
Fungal specific transcription factor domain; This domain is found in a number of fungal ...
 173-311 1.30e-03

Fungal specific transcription factor domain; This domain is found in a number of fungal transcription factors including transcriptional activator xlnR, yeast regulatory protein GAL4, and nicotinate catabolism cluster-specific transcription factor HxnR.


Pssm-ID: 397964  Cd Length: 262  Bit Score: 40.55  E-value: 1.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946690  173 IMTYYCLhrcyaQFADTRTSYRLSCEAVGLIKIAGFHREETYE----FLPFGEQQLRRKVYYLLLMTERFYAVYIKCVTS 248
Cdd:pfam04082  99 LLELYEL-----GTGDRKLHWRYHGLAIRLARSLGLHRDPSYVspswKLWIEEAELRRRLFWACFYLDRLISLILGRPPL 173

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 151946690  249 LDAT-IAPPLPEVVTDprlslESFLEVIRVFTIPGkcfyDALATNCVDDSCTEDSLKRIWNELH 311
Cdd:pfam04082 174 LSDSdIDLPLPCDDDD-----LWESDSADEVTLPL----ISLESKSIKPPLFLIKLSKILSKIL 228
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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