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conserved protein [Saccharomyces cerevisiae YJM789]
Protein Classification
amidohydrolase family protein ( domain architecture ID 330 )
metal-dependent amidohydrolase family protein having a conserved metal binding site, usually involving four histidines and one aspartic acid residue
List of domain hits
Name
Accession
Description
Interval
E-value
metallo-dependent_hydrolases super family
cl00281 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a ...
219-791
1.79e-93
Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a conserved metal binding site, involving four histidines and one aspartic acid residue. In the common reaction mechanism, the metal ion (or ions) deprotonate a water molecule for a nucleophilic attack on the substrate. The family includes urease alpha, adenosine deaminase, phosphotriesterase dihydroorotases, allantoinases, hydantoinases, AMP-, adenine and cytosine deaminases, imidazolonepropionase, aryldialkylphosphatase, chlorohydrolases, formylmethanofuran dehydrogenases and others.
cd01319 :Pssm-ID: 469705
Cd Length: 496
Bit Score: 301.59
E-value: 1.79e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 219 F RE D F E WC L KI I R D RSLSR F SEK RLQYL VN KF PVFQH L HSKE E MRQS K K VPH K DFYN C RK I D LNLLL S G C FS Q WQ L TE FI 298
Cdd:cd01319 1 F YL D L E FL L AL I S D GPAKS F CYR RLQYL ES KF QLHVL L NEDR E LKEQ K T VPH R DFYN V RK V D THVHH S A C MN Q KH L LR FI 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 299 WT KLR K EPD R V IHQA f N G SHI TL SQL F KV nfeetgqffng LK I iddsflewykviyp AK Y H L VN D EMEI H TGSHGKQ --- 375
Cdd:cd01319 81 KK KLR T EPD E V VIFR - D G KKL TL KEV F DS ----------- LK L -------------- TA Y D L SV D TLDV H ADRNTFH rfd 134
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 376 --- L R Y YL I AKT ----- FL EF DNYING E YLAE LL K T f LIKPQ EESKYQ LCQ -- LS V dfqfylh Y DN S D vd NW W MVF A N W L 445
Cdd:cd01319 135 kfn L K Y NP I GES rlrei FL KT DNYING R YLAE IT K E - VFSDL EESKYQ HAE yr LS I ------- Y GR S K -- DE W DKL A S W V 204
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 446 NHYNI FS N N I RW N I R I S R I Y PELYHT G K V KN FQE Y L NL IF K PLF N A EN yl HK S LG P I L LK FL S QV SSI D LCIQDTDNY iw 525
Cdd:cd01319 205 VDNDL FS P N V RW L I Q I P R L Y DVYKKS G I V NS FQE M L EN IF E PLF E A TK -- DP S SH P E L HV FL Q QV IGF D SVDDESKSE -- 280
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 526 KN FT AVSCL P KD WTS G g D NP TI S Q Y M YY V Y V N L T K LN HI R Q A LHQ NTF T LR SS C SPTS mnrtsqfsntlnfte HTETILN 605
Cdd:cd01319 281 RR FT RKFPK P EE WTS E - E NP PY S Y Y L YY M Y A N I T T LN SF R K A RGF NTF V LR PH C GEAG --------------- DIDHLAS 344
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 606 N FLLA C G gf LNAENLWNAP P S L V YL F YL S QI PMVVA PL nsivd SN PT mlqeqaptg L V L E pskp Y K KNPF MK FF EM G FKI 685
Cdd:cd01319 345 A FLLA H G -- ISHGINLRKV P V L Q YL Y YL T QI GIAMS PL ----- SN NS --------- L F L S ---- Y E KNPF PE FF KR G LNV 404
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 686 SLS SESI L y NNSY TKEP II EEYS V AA SIYR L HSA D L CEL L RNSV IT SGF SSTL K NK WLG vslashdyfventgfv DKWYD 765
Cdd:cd01319 405 SLS TDDP L - QFHF TKEP LM EEYS I AA QVWK L STC D M CEL A RNSV LQ SGF EHSI K RH WLG ---------------- PNYLK 467
570 580
....*....|....*....|....*...
gi 151946669 766 CKPNTTLEH -- NVP I IR RQ YR SS TL AG E 791
Cdd:cd01319 468 RGVAGNDIR rt NVP Q IR MA YR YE TL CE E 495
Name
Accession
Description
Interval
E-value
AMPD
cd01319 AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at ...
219-791
1.79e-93
AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.
Pssm-ID: 238644
Cd Length: 496
Bit Score: 301.59
E-value: 1.79e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 219 F RE D F E WC L KI I R D RSLSR F SEK RLQYL VN KF PVFQH L HSKE E MRQS K K VPH K DFYN C RK I D LNLLL S G C FS Q WQ L TE FI 298
Cdd:cd01319 1 F YL D L E FL L AL I S D GPAKS F CYR RLQYL ES KF QLHVL L NEDR E LKEQ K T VPH R DFYN V RK V D THVHH S A C MN Q KH L LR FI 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 299 WT KLR K EPD R V IHQA f N G SHI TL SQL F KV nfeetgqffng LK I iddsflewykviyp AK Y H L VN D EMEI H TGSHGKQ --- 375
Cdd:cd01319 81 KK KLR T EPD E V VIFR - D G KKL TL KEV F DS ----------- LK L -------------- TA Y D L SV D TLDV H ADRNTFH rfd 134
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 376 --- L R Y YL I AKT ----- FL EF DNYING E YLAE LL K T f LIKPQ EESKYQ LCQ -- LS V dfqfylh Y DN S D vd NW W MVF A N W L 445
Cdd:cd01319 135 kfn L K Y NP I GES rlrei FL KT DNYING R YLAE IT K E - VFSDL EESKYQ HAE yr LS I ------- Y GR S K -- DE W DKL A S W V 204
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 446 NHYNI FS N N I RW N I R I S R I Y PELYHT G K V KN FQE Y L NL IF K PLF N A EN yl HK S LG P I L LK FL S QV SSI D LCIQDTDNY iw 525
Cdd:cd01319 205 VDNDL FS P N V RW L I Q I P R L Y DVYKKS G I V NS FQE M L EN IF E PLF E A TK -- DP S SH P E L HV FL Q QV IGF D SVDDESKSE -- 280
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 526 KN FT AVSCL P KD WTS G g D NP TI S Q Y M YY V Y V N L T K LN HI R Q A LHQ NTF T LR SS C SPTS mnrtsqfsntlnfte HTETILN 605
Cdd:cd01319 281 RR FT RKFPK P EE WTS E - E NP PY S Y Y L YY M Y A N I T T LN SF R K A RGF NTF V LR PH C GEAG --------------- DIDHLAS 344
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 606 N FLLA C G gf LNAENLWNAP P S L V YL F YL S QI PMVVA PL nsivd SN PT mlqeqaptg L V L E pskp Y K KNPF MK FF EM G FKI 685
Cdd:cd01319 345 A FLLA H G -- ISHGINLRKV P V L Q YL Y YL T QI GIAMS PL ----- SN NS --------- L F L S ---- Y E KNPF PE FF KR G LNV 404
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 686 SLS SESI L y NNSY TKEP II EEYS V AA SIYR L HSA D L CEL L RNSV IT SGF SSTL K NK WLG vslashdyfventgfv DKWYD 765
Cdd:cd01319 405 SLS TDDP L - QFHF TKEP LM EEYS I AA QVWK L STC D M CEL A RNSV LQ SGF EHSI K RH WLG ---------------- PNYLK 467
570 580
....*....|....*....|....*...
gi 151946669 766 CKPNTTLEH -- NVP I IR RQ YR SS TL AG E 791
Cdd:cd01319 468 RGVAGNDIR rt NVP Q IR MA YR YE TL CE E 495
AMP_deaminase
pfam19326 AMP deaminase;
213-795
3.15e-89
AMP deaminase;
Pssm-ID: 437158 [Multi-domain]
Cd Length: 622
Bit Score: 293.98
E-value: 3.15e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 213 I P TFKE F RE D F E WC L KI I R D RSLSR F SEK RLQYL VN KF PVFQH L HSKE E MRQS K KV PH K DFYN C RK I D LNLLL S G C FS Q W 292
Cdd:pfam19326 112 Y P DLRD F YT D L E HL L AL I A D GPIKT F CHR RLQYL ES KF NLHLM L NEMK E LKAQ K SN PH R DFYN V RK V D THVHH S A C MN Q K 191
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 293 Q L TE FI WT KLRKEPD R V IHQA f N G SHI TL SQL F K vnfeetgqffn G LK I iddsflewykviyp AK Y H L VN D EMEI H TGSH 372
Cdd:pfam19326 192 H L LR FI KS KLRKEPD E V VIFR - D G KYL TL REV F E ----------- S LK L -------------- TG Y D L SV D TLDV H ADRD 245
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 373 GKQ ------ L R Y YL I AKT ----- FL EF DNYING E YLAE LL K T f LIKPQ EESKYQ LCQLSVDF qfylh Y DN S DVD nw W MVF 441
Cdd:pfam19326 246 TFH rfdkfn L K Y NP I GES rlrei FL KT DNYING R YLAE IT K E - VFSDL EESKYQ MAEYRISI ----- Y GR S PDE -- W DKL 317
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 442 A N W LNHYNIF S N N I RW N I RIS R I Y PELYHT G K V KN FQ EY L NL IF K PLF N A E ny LHKSLG P I L LK FL SQ V SSI D LC iq D TD 521
Cdd:pfam19326 318 A S W IVDNKVY S P N V RW L I QVP R L Y DIYKKK G I V PS FQ KM L EN IF L PLF E A T -- VNPQSH P E L HV FL KR V IGF D SV -- D DE 393
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 522 NYIWKNFTAV S CL P KD WT SG g D NP TI S Q Y M YY V Y V N LTK LN HI R QALHQ NTF T LR SS C SPTS mnrtsqfsntlnfte HTE 601
Cdd:pfam19326 394 SKPERRMFRK S PK P AL WT NE - Q NP PY S Y Y L YY M Y A N IAV LN SL R KERGF NTF V LR PH C GEAG --------------- DID 457
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 602 TILNN FLLA C G gf LNAEN L WNAP P S L V YL F YL S QI PMVVA PL nsivd SN ptmlqeqap TG L V LE pskp Y K KNPF MK FF EM 681
Cdd:pfam19326 458 HLVSA FLLA H G -- ISHGI L LRKS P V L Q YL Y YL A QI GIAMS PL ----- SN --------- NS L F LE ---- Y H KNPF PE FF KR 517
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 682 G FKI SLS SESI L y NNSY TKEP II EEYS V AA SIYR L HSA D L CEL L RNSV IT SGFS ST LK NK WLG V slash DY FV E NT gfvd 761
Cdd:pfam19326 518 G LNV SLS TDDP L - QFHF TKEP LM EEYS I AA QVWK L SAC D M CEL A RNSV LQ SGFS HQ LK SH WLG K ----- DY YK E GP ---- 587
570 580 590
....*....|....*....|....*....|....
gi 151946669 762 kwydc KP N TTLEH NVP I IR RQ YR SS TL AG E WR LI 795
Cdd:pfam19326 588 ----- EG N DIRRT NVP D IR VA YR YE TL CQ E LA LI 616
AMP_deaminase
TIGR01429 AMP deaminase; This model describes AMP deaminase, a large, well-conserved eukaryotic protein ...
199-795
2.64e-88
AMP deaminase; This model describes AMP deaminase, a large, well-conserved eukaryotic protein involved in energy metabolism. Most members of the family have an additional, poorly alignable region of 150 amino acids or more N-terminal to the region included in the model.
Pssm-ID: 273618 [Multi-domain]
Cd Length: 611
Bit Score: 291.36
E-value: 2.64e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 199 D GNYMTELFNSQIN i PT FKEFRE D F E WC L KI I R D RSLSR F SEK RLQYL VN KF PVFQH L HSKE E MRQS K K VPH K DFYN C RK 278
Cdd:TIGR01429 93 D TMLERQEPHFLVP - PT LETYYV D M E HL L AL I S D GPTKS F CFR RLQYL ES KF NLHEL L NEMS E LKEQ K S VPH R DFYN V RK 171
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 279 I D LNLLLSGCFS Q WQ L TE FI WT KL RK EPD RVIHQA f N G SHI TL SQL F K vnfeetgqffn G L KI id D S flewykviypak Y 358
Cdd:TIGR01429 172 V D THIHAAASMN Q KH L LR FI KH KL KT EPD ETVIER - D G KKL TL REV F D ----------- S L HL -- D P ------------ Y 225
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 359 H L VN D EMEI H TGSHGKQ ------ L R Y YLIAKT ----- FL EF DNYI N G E Y L AEL L K TFL i KPQ E E SKYQ LCQ -- LS V dfqf 425
Cdd:TIGR01429 226 D L SV D TLDV H ADRNTFH rfdkfn L K Y NPVGES rlrei FL KT DNYI G G K Y F AEL V K EVF - TDL E D SKYQ YAE pr LS I ---- 300
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 426 ylh Y DN S D vd NW W MVF A N W LNHYNI FS N N I RW N I RIS R I Y PELYHTGK V K NF QEY L NLI F K PLF NAEN yl HK S LG P I L LK 505
Cdd:TIGR01429 301 --- Y GR S P -- KE W DSL A R W IIDHDV FS P N V RW L I QVP R L Y DVYRSKKL V P NF GDM L ENV F L PLF EVTK -- DP S SH P E L HL 373
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 506 FL S QV SSI D l CIQ D TDNYIWKN F TAVSCL P KD WTS G g D NP TI S Q Y M YY V Y V N LTK LN HI R QALHQ NTF T LR SS C SPTS mn 585
Cdd:TIGR01429 374 FL Q QV TGF D - SVD D ESKHEDHM F SRKFPS P DE WTS E - Q NP PY S Y Y L YY M Y A N IMV LN NF R RERGL NTF L LR PH C GEAG -- 449
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 586 rtsqfsntlnfte HTETILNN FL LAC G gf L N AEN L WNAP P S L V YL F YL S QIP MVVA PL nsivd SN PTMLQ E qaptglvle 665
Cdd:TIGR01429 450 ------------- SVDHLVSA FL TSH G -- I N HGI L LRKV P V L Q YL Y YL T QIP IAMS PL ----- SN NSLFL E --------- 500
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 666 pskp Y K KNP FMKFFEM G FKI SLS SESI L y NNS YTKE PII EEY SV AA SIYR L HSA D L CEL L RNSV IT SGF SSTL K NK WLG V 745
Cdd:TIGR01429 501 ---- Y S KNP LPEYLHK G LNV SLS TDDP L - QFH YTKE ALM EEY AI AA QVWK L STC D M CEL A RNSV LQ SGF EHQV K QH WLG P 575
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|
gi 151946669 746 slash D Y FV E NT gfvdkwydc KP N TTLEH NVP I IR RQY R SS TL AG E WR L I 795
Cdd:TIGR01429 576 ----- N Y YK E GP --------- EG N DIRRT NVP D IR VAF R YE TL CN E LS L L 611
PLN03055
PLN03055 AMP deaminase; Provisional
213-795
6.28e-70
AMP deaminase; Provisional
Pssm-ID: 178613
Cd Length: 602
Bit Score: 241.69
E-value: 6.28e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 213 I P TFKE F RE D FEWC L K I IRDRSLSR F SEK RL QY L VN KF PVFQH L HSKE E MRQS K KV PH K DFYN C RK I D LNLLL S G C FS Q W 292
Cdd:PLN03055 85 V P DATT F FT D MHRI L R I VSLGNVRT F CHH RL KL L EQ KF SLHLM L NADR E FLAQ K SA PH R DFYN V RK V D THVHH S S C MN Q K 164
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 293 Q L TE FI WT KLRKEPD R - VI HQ af N G SHI TL SQL F K v NFEE TG qffnglkiiddsflewykviypak Y H L VN D EMEI H TGS 371
Cdd:PLN03055 165 H L LR FI KS KLRKEPD E v VI FR -- D G KYL TL REV F E - SLDL TG ------------------------ Y D L NV D LLDV H ADK 217
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 372 HGKQ ------ L R Y YLIAKT ----- FL EF DN Y I N G EY LAEL L K T f LIKPQ E E SKYQ LCQLSVDF qfylh Y DNSDVD nw W MV 440
Cdd:PLN03055 218 NTFH rfdkfn L K Y NPCGQS rlrei FL KQ DN L I Q G RF LAEL T K E - VFSDL E A SKYQ MAEYRISI ----- Y GRKQSE -- W DQ 289
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 441 F A N W LNHYNIF S N N IR W N I RIS R I Y PELYHT G K V KN FQ EY L NL IFKPLF na E NYLHK S LG P I L LK FL SQ V SSI D LC iq D T 520
Cdd:PLN03055 290 L A S W IVNNRLY S E N VV W L I QLP R L Y NVYKEM G I V QS FQ QI L DN IFKPLF -- E VTVDP S SH P Q L HV FL KM V VGF D MV -- D D 365
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 521 DNYIWKNF T AVSCL P KD W TSG g D NP TI S QYM YYVY V NL TK LN HI R QALHQ NT FTL R SS csptsmnrtsqf SNTLNFTE H T 600
Cdd:PLN03055 366 ESKPERRP T KHMQT P EQ W DIP - F NP AY S YWA YYVY A NL YT LN KL R ESKGL NT IKF R PH ------------ AGEAGDID H L 432
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 601 etilnnflla CGG FL N A E N LWNA ----- P P S L V YL F YL S QI PMVVA PL nsivd SN PTMLQE qaptglvlepskp Y KK NPF 675
Cdd:PLN03055 433 ---------- AAA FL L A H N IAHG nnlrk S P G L Q YL Y YL A QI GLAMS PL ----- SN NSLFLD ------------- Y HR NPF 484
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 676 MK FF EM G FKI SLS SESI L YNN s Y TKEP II EEYS V AA SIYR L H S A DLCE LL RNSV IT SGF SSTL K NK W L G vslas HD Y FVE 755
Cdd:PLN03055 485 PM FF AR G LNV SLS TDDP L QIH - L TKEP LV EEYS I AA QVWK L S S C DLCE IA RNSV LQ SGF PHAS K KH W V G ----- DN Y WLR 558
570 580 590 600
....*....|....*....|....*....|....*....|
gi 151946669 756 NT gfvdkwydc KP N TTLEH NVP II R RQY R SSTLAG E WRLI 795
Cdd:PLN03055 559 GP --------- AG N DIHKT NVP HM R VEF R HEVWKE E LQYV 589
Name
Accession
Description
Interval
E-value
AMPD
cd01319 AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at ...
219-791
1.79e-93
AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.
Pssm-ID: 238644
Cd Length: 496
Bit Score: 301.59
E-value: 1.79e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 219 F RE D F E WC L KI I R D RSLSR F SEK RLQYL VN KF PVFQH L HSKE E MRQS K K VPH K DFYN C RK I D LNLLL S G C FS Q WQ L TE FI 298
Cdd:cd01319 1 F YL D L E FL L AL I S D GPAKS F CYR RLQYL ES KF QLHVL L NEDR E LKEQ K T VPH R DFYN V RK V D THVHH S A C MN Q KH L LR FI 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 299 WT KLR K EPD R V IHQA f N G SHI TL SQL F KV nfeetgqffng LK I iddsflewykviyp AK Y H L VN D EMEI H TGSHGKQ --- 375
Cdd:cd01319 81 KK KLR T EPD E V VIFR - D G KKL TL KEV F DS ----------- LK L -------------- TA Y D L SV D TLDV H ADRNTFH rfd 134
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 376 --- L R Y YL I AKT ----- FL EF DNYING E YLAE LL K T f LIKPQ EESKYQ LCQ -- LS V dfqfylh Y DN S D vd NW W MVF A N W L 445
Cdd:cd01319 135 kfn L K Y NP I GES rlrei FL KT DNYING R YLAE IT K E - VFSDL EESKYQ HAE yr LS I ------- Y GR S K -- DE W DKL A S W V 204
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 446 NHYNI FS N N I RW N I R I S R I Y PELYHT G K V KN FQE Y L NL IF K PLF N A EN yl HK S LG P I L LK FL S QV SSI D LCIQDTDNY iw 525
Cdd:cd01319 205 VDNDL FS P N V RW L I Q I P R L Y DVYKKS G I V NS FQE M L EN IF E PLF E A TK -- DP S SH P E L HV FL Q QV IGF D SVDDESKSE -- 280
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 526 KN FT AVSCL P KD WTS G g D NP TI S Q Y M YY V Y V N L T K LN HI R Q A LHQ NTF T LR SS C SPTS mnrtsqfsntlnfte HTETILN 605
Cdd:cd01319 281 RR FT RKFPK P EE WTS E - E NP PY S Y Y L YY M Y A N I T T LN SF R K A RGF NTF V LR PH C GEAG --------------- DIDHLAS 344
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 606 N FLLA C G gf LNAENLWNAP P S L V YL F YL S QI PMVVA PL nsivd SN PT mlqeqaptg L V L E pskp Y K KNPF MK FF EM G FKI 685
Cdd:cd01319 345 A FLLA H G -- ISHGINLRKV P V L Q YL Y YL T QI GIAMS PL ----- SN NS --------- L F L S ---- Y E KNPF PE FF KR G LNV 404
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 686 SLS SESI L y NNSY TKEP II EEYS V AA SIYR L HSA D L CEL L RNSV IT SGF SSTL K NK WLG vslashdyfventgfv DKWYD 765
Cdd:cd01319 405 SLS TDDP L - QFHF TKEP LM EEYS I AA QVWK L STC D M CEL A RNSV LQ SGF EHSI K RH WLG ---------------- PNYLK 467
570 580
....*....|....*....|....*...
gi 151946669 766 CKPNTTLEH -- NVP I IR RQ YR SS TL AG E 791
Cdd:cd01319 468 RGVAGNDIR rt NVP Q IR MA YR YE TL CE E 495
AMP_deaminase
pfam19326 AMP deaminase;
213-795
3.15e-89
AMP deaminase;
Pssm-ID: 437158 [Multi-domain]
Cd Length: 622
Bit Score: 293.98
E-value: 3.15e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 213 I P TFKE F RE D F E WC L KI I R D RSLSR F SEK RLQYL VN KF PVFQH L HSKE E MRQS K KV PH K DFYN C RK I D LNLLL S G C FS Q W 292
Cdd:pfam19326 112 Y P DLRD F YT D L E HL L AL I A D GPIKT F CHR RLQYL ES KF NLHLM L NEMK E LKAQ K SN PH R DFYN V RK V D THVHH S A C MN Q K 191
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 293 Q L TE FI WT KLRKEPD R V IHQA f N G SHI TL SQL F K vnfeetgqffn G LK I iddsflewykviyp AK Y H L VN D EMEI H TGSH 372
Cdd:pfam19326 192 H L LR FI KS KLRKEPD E V VIFR - D G KYL TL REV F E ----------- S LK L -------------- TG Y D L SV D TLDV H ADRD 245
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 373 GKQ ------ L R Y YL I AKT ----- FL EF DNYING E YLAE LL K T f LIKPQ EESKYQ LCQLSVDF qfylh Y DN S DVD nw W MVF 441
Cdd:pfam19326 246 TFH rfdkfn L K Y NP I GES rlrei FL KT DNYING R YLAE IT K E - VFSDL EESKYQ MAEYRISI ----- Y GR S PDE -- W DKL 317
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 442 A N W LNHYNIF S N N I RW N I RIS R I Y PELYHT G K V KN FQ EY L NL IF K PLF N A E ny LHKSLG P I L LK FL SQ V SSI D LC iq D TD 521
Cdd:pfam19326 318 A S W IVDNKVY S P N V RW L I QVP R L Y DIYKKK G I V PS FQ KM L EN IF L PLF E A T -- VNPQSH P E L HV FL KR V IGF D SV -- D DE 393
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 522 NYIWKNFTAV S CL P KD WT SG g D NP TI S Q Y M YY V Y V N LTK LN HI R QALHQ NTF T LR SS C SPTS mnrtsqfsntlnfte HTE 601
Cdd:pfam19326 394 SKPERRMFRK S PK P AL WT NE - Q NP PY S Y Y L YY M Y A N IAV LN SL R KERGF NTF V LR PH C GEAG --------------- DID 457
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 602 TILNN FLLA C G gf LNAEN L WNAP P S L V YL F YL S QI PMVVA PL nsivd SN ptmlqeqap TG L V LE pskp Y K KNPF MK FF EM 681
Cdd:pfam19326 458 HLVSA FLLA H G -- ISHGI L LRKS P V L Q YL Y YL A QI GIAMS PL ----- SN --------- NS L F LE ---- Y H KNPF PE FF KR 517
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 682 G FKI SLS SESI L y NNSY TKEP II EEYS V AA SIYR L HSA D L CEL L RNSV IT SGFS ST LK NK WLG V slash DY FV E NT gfvd 761
Cdd:pfam19326 518 G LNV SLS TDDP L - QFHF TKEP LM EEYS I AA QVWK L SAC D M CEL A RNSV LQ SGFS HQ LK SH WLG K ----- DY YK E GP ---- 587
570 580 590
....*....|....*....|....*....|....
gi 151946669 762 kwydc KP N TTLEH NVP I IR RQ YR SS TL AG E WR LI 795
Cdd:pfam19326 588 ----- EG N DIRRT NVP D IR VA YR YE TL CQ E LA LI 616
AMP_deaminase
TIGR01429 AMP deaminase; This model describes AMP deaminase, a large, well-conserved eukaryotic protein ...
199-795
2.64e-88
AMP deaminase; This model describes AMP deaminase, a large, well-conserved eukaryotic protein involved in energy metabolism. Most members of the family have an additional, poorly alignable region of 150 amino acids or more N-terminal to the region included in the model.
Pssm-ID: 273618 [Multi-domain]
Cd Length: 611
Bit Score: 291.36
E-value: 2.64e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 199 D GNYMTELFNSQIN i PT FKEFRE D F E WC L KI I R D RSLSR F SEK RLQYL VN KF PVFQH L HSKE E MRQS K K VPH K DFYN C RK 278
Cdd:TIGR01429 93 D TMLERQEPHFLVP - PT LETYYV D M E HL L AL I S D GPTKS F CFR RLQYL ES KF NLHEL L NEMS E LKEQ K S VPH R DFYN V RK 171
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 279 I D LNLLLSGCFS Q WQ L TE FI WT KL RK EPD RVIHQA f N G SHI TL SQL F K vnfeetgqffn G L KI id D S flewykviypak Y 358
Cdd:TIGR01429 172 V D THIHAAASMN Q KH L LR FI KH KL KT EPD ETVIER - D G KKL TL REV F D ----------- S L HL -- D P ------------ Y 225
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 359 H L VN D EMEI H TGSHGKQ ------ L R Y YLIAKT ----- FL EF DNYI N G E Y L AEL L K TFL i KPQ E E SKYQ LCQ -- LS V dfqf 425
Cdd:TIGR01429 226 D L SV D TLDV H ADRNTFH rfdkfn L K Y NPVGES rlrei FL KT DNYI G G K Y F AEL V K EVF - TDL E D SKYQ YAE pr LS I ---- 300
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 426 ylh Y DN S D vd NW W MVF A N W LNHYNI FS N N I RW N I RIS R I Y PELYHTGK V K NF QEY L NLI F K PLF NAEN yl HK S LG P I L LK 505
Cdd:TIGR01429 301 --- Y GR S P -- KE W DSL A R W IIDHDV FS P N V RW L I QVP R L Y DVYRSKKL V P NF GDM L ENV F L PLF EVTK -- DP S SH P E L HL 373
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 506 FL S QV SSI D l CIQ D TDNYIWKN F TAVSCL P KD WTS G g D NP TI S Q Y M YY V Y V N LTK LN HI R QALHQ NTF T LR SS C SPTS mn 585
Cdd:TIGR01429 374 FL Q QV TGF D - SVD D ESKHEDHM F SRKFPS P DE WTS E - Q NP PY S Y Y L YY M Y A N IMV LN NF R RERGL NTF L LR PH C GEAG -- 449
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 586 rtsqfsntlnfte HTETILNN FL LAC G gf L N AEN L WNAP P S L V YL F YL S QIP MVVA PL nsivd SN PTMLQ E qaptglvle 665
Cdd:TIGR01429 450 ------------- SVDHLVSA FL TSH G -- I N HGI L LRKV P V L Q YL Y YL T QIP IAMS PL ----- SN NSLFL E --------- 500
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 666 pskp Y K KNP FMKFFEM G FKI SLS SESI L y NNS YTKE PII EEY SV AA SIYR L HSA D L CEL L RNSV IT SGF SSTL K NK WLG V 745
Cdd:TIGR01429 501 ---- Y S KNP LPEYLHK G LNV SLS TDDP L - QFH YTKE ALM EEY AI AA QVWK L STC D M CEL A RNSV LQ SGF EHQV K QH WLG P 575
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|
gi 151946669 746 slash D Y FV E NT gfvdkwydc KP N TTLEH NVP I IR RQY R SS TL AG E WR L I 795
Cdd:TIGR01429 576 ----- N Y YK E GP --------- EG N DIRRT NVP D IR VAF R YE TL CN E LS L L 611
ADA_AMPD
cd00443 Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic ...
276-745
1.92e-70
Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase catalyzes a similar reaction leading to the hydrolytic removal of an amino group at the 6 position of the adenine nucleotide ring, a branch point in the adenylate catabolic pathway.
Pssm-ID: 238250
Cd Length: 305
Bit Score: 233.78
E-value: 1.92e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 276 CR K ID L NLL LSG CF S QWQ L T E F I WTKL rkepdrvihqafngshitlsqlfkvnfeetgqffnglkiiddsflewykviyp 355
Cdd:cd00443 1 LP K VE L HAH LSG SI S PET L L E L I KKEF ----------------------------------------------------- 27
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 356 akyhlvndemeihtgshgkqlryyli AKT FL EFD N Y - IN GE Y LA EL LK t FL I KPQE E SKY Q LCQ L SVDFQFYLHY dnsdv 434
Cdd:cd00443 28 -------------------------- FEK FL LVH N L l QK GE A LA RA LK - EV I EEFA E DNV Q YLE L RTTPRLLETE ----- 75
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 435 d NWWMVFAN WL NHYNIF S NNIR W N -- I RISR I YPELYHTGK V K N fqeylnlifkplfnaen YL HK S LGPI L L KFLS Q - V S 511
Cdd:cd00443 76 - KGLTKEQY WL LVIEGI S EAKQ W F pp I KVRL I LSVDRRGPY V Q N ----------------- YL VA S EILE L A KFLS N y V V 137
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 512 S IDL CIQDTDNY iwknftavsclpkdwtsggd NP TISQ Y M YY V Y VNLTK L nhirqalhqnt FT L RSS C SP T smnrtsqfs 591
Cdd:cd00443 138 G IDL VGDESKGE -------------------- NP LRDF Y S YY E Y ARRLG L ----------- LG L TLH C GE T --------- 177
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 592 ntlnft EHT E TI L NNF LL - ACGGFLNAEN L WN ap P S L V YL FY L SQ IP MV V A P LNSI V DSNPT mlqeqaptglvlepsk P Y 670
Cdd:cd00443 178 ------ GNR E EL L QAL LL l PDRIGHGIFL L KH -- P E L I YL VK L RN IP IE V C P TSNV V LGTVQ ---------------- S Y 233
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 151946669 671 K K N PFM K FF EM G FKI SLS SESILYNNS ytke PII EEYS V AA SIYR L HSA DLCEL L RNSV IT S GFSSTL K NKW L G V 745
Cdd:cd00443 234 E K H PFM R FF KA G LPV SLS TDDPGIFGT ---- SLS EEYS L AA KTFG L TFE DLCEL N RNSV LS S FAKDEE K KSL L E V 304
PLN03055
PLN03055 AMP deaminase; Provisional
213-795
6.28e-70
AMP deaminase; Provisional
Pssm-ID: 178613
Cd Length: 602
Bit Score: 241.69
E-value: 6.28e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 213 I P TFKE F RE D FEWC L K I IRDRSLSR F SEK RL QY L VN KF PVFQH L HSKE E MRQS K KV PH K DFYN C RK I D LNLLL S G C FS Q W 292
Cdd:PLN03055 85 V P DATT F FT D MHRI L R I VSLGNVRT F CHH RL KL L EQ KF SLHLM L NADR E FLAQ K SA PH R DFYN V RK V D THVHH S S C MN Q K 164
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 293 Q L TE FI WT KLRKEPD R - VI HQ af N G SHI TL SQL F K v NFEE TG qffnglkiiddsflewykviypak Y H L VN D EMEI H TGS 371
Cdd:PLN03055 165 H L LR FI KS KLRKEPD E v VI FR -- D G KYL TL REV F E - SLDL TG ------------------------ Y D L NV D LLDV H ADK 217
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 372 HGKQ ------ L R Y YLIAKT ----- FL EF DN Y I N G EY LAEL L K T f LIKPQ E E SKYQ LCQLSVDF qfylh Y DNSDVD nw W MV 440
Cdd:PLN03055 218 NTFH rfdkfn L K Y NPCGQS rlrei FL KQ DN L I Q G RF LAEL T K E - VFSDL E A SKYQ MAEYRISI ----- Y GRKQSE -- W DQ 289
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 441 F A N W LNHYNIF S N N IR W N I RIS R I Y PELYHT G K V KN FQ EY L NL IFKPLF na E NYLHK S LG P I L LK FL SQ V SSI D LC iq D T 520
Cdd:PLN03055 290 L A S W IVNNRLY S E N VV W L I QLP R L Y NVYKEM G I V QS FQ QI L DN IFKPLF -- E VTVDP S SH P Q L HV FL KM V VGF D MV -- D D 365
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 521 DNYIWKNF T AVSCL P KD W TSG g D NP TI S QYM YYVY V NL TK LN HI R QALHQ NT FTL R SS csptsmnrtsqf SNTLNFTE H T 600
Cdd:PLN03055 366 ESKPERRP T KHMQT P EQ W DIP - F NP AY S YWA YYVY A NL YT LN KL R ESKGL NT IKF R PH ------------ AGEAGDID H L 432
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 601 etilnnflla CGG FL N A E N LWNA ----- P P S L V YL F YL S QI PMVVA PL nsivd SN PTMLQE qaptglvlepskp Y KK NPF 675
Cdd:PLN03055 433 ---------- AAA FL L A H N IAHG nnlrk S P G L Q YL Y YL A QI GLAMS PL ----- SN NSLFLD ------------- Y HR NPF 484
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 676 MK FF EM G FKI SLS SESI L YNN s Y TKEP II EEYS V AA SIYR L H S A DLCE LL RNSV IT SGF SSTL K NK W L G vslas HD Y FVE 755
Cdd:PLN03055 485 PM FF AR G LNV SLS TDDP L QIH - L TKEP LV EEYS I AA QVWK L S S C DLCE IA RNSV LQ SGF PHAS K KH W V G ----- DN Y WLR 558
570 580 590 600
....*....|....*....|....*....|....*....|
gi 151946669 756 NT gfvdkwydc KP N TTLEH NVP II R RQY R SSTLAG E WRLI 795
Cdd:PLN03055 559 GP --------- AG N DIHKT NVP HM R VEF R HEVWKE E LQYV 589
PLN02768
PLN02768 AMP deaminase
219-795
9.37e-64
AMP deaminase
Pssm-ID: 215411
Cd Length: 835
Bit Score: 228.98
E-value: 9.37e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 219 F RE D FEWC L KI I RDRSLSRFSEK RL QY L VN KF PVFQH L HSKE E MRQS K KV PH K DFYN C RK I D LNLLL S G C FS Q WQ L TE FI 298
Cdd:PLN02768 324 F FT D LHHI L RV I AAGNIRTLCHH RL NL L EQ KF NLHLM L NADR E FLAQ K SA PH R DFYN V RK V D THVHH S A C MN Q KH L LR FI 403
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 299 WT KLRKEPD R V I hq A F - N G SHI TL SQL F K v NFEE TG QFF N g LKII D ----- DS F LEWY K vi YPA KY HLVNDE meihtgsh 372
Cdd:PLN02768 404 KS KLRKEPD E V V -- I F r D G TYL TL KEV F E - SLDL TG YDL N - VDLL D vhadk ST F HRFD K -- FNL KY NPCGQS -------- 469
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 373 gk Q LR yylia KT FL EF DN Y I N G EY LAEL L K TFL i KPQ E E SKYQ LCQLSVDF qfylh Y DNSDVD nw W MVF A N W LNHYNIF S 452
Cdd:PLN02768 470 -- R LR ----- EI FL KQ DN L I Q G RF LAEL T K QVF - SDL E A SKYQ MAEYRISI ----- Y GRKQSE -- W DQL A S W IVNNELY S 534
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 453 N N IR W N I RIS R I Y PELYHT G K V KN FQ EY L NL IF K PLF na E NYLHKSLG P I L LK FL S QV SSI DL C iq D TDNYIWKNF T AVS 532
Cdd:PLN02768 535 E N VV W L I QLP R L Y NVYKEM G I V TS FQ NI L DN IF I PLF -- E VTVDPDSH P Q L HV FL K QV VGL DL V -- D DESKPERRP T KHM 610
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 533 CL P KD WT SGG d NP TI S Q Y M YY V Y V NL TK LN HI R QALHQN T FTL R SSCSPTSM nrtsqfsntlnf TE H teti L NNFL L A C G 612
Cdd:PLN02768 611 PT P AQ WT NVF - NP AF S Y Y V YY C Y A NL YT LN KL R ESKGMT T IKF R PHSGEAGD ------------ ID H ---- L AATF L T C H 673
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 613 GFLNAE NL WNA P p S L V YL F YL S QI PMVVA PL nsivd SN PTMLQE qaptglvlepskp Y KK NPF MK FF EM G FKI SLS SESI 692
Cdd:PLN02768 674 NIAHGI NL RKS P - V L Q YL Y YL A QI GLAMS PL ----- SN NSLFLD ------------- Y HR NPF PM FF LR G LNV SLS TDDP 734
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 693 L YNN s Y TKEP II EEYS V AAS IYR L H S A DLCE LL RNSV IT SGFS ST LK NK W L G vslashdyfventgfv DKW Y DCK P -- N T 770
Cdd:PLN02768 735 L QIH - L TKEP LV EEYS I AAS VWK L S S C DLCE IA RNSV YQ SGFS HA LK SH W I G ---------------- KEY Y KRG P dg N D 797
570 580
....*....|....*....|....*
gi 151946669 771 TLEH NVP I IR RQY R SSTLAG E WRLI 795
Cdd:PLN02768 798 IHKT NVP H IR VEF R DTIWKE E MQQV 822
PTZ00310
PTZ00310 AMP deaminase; Provisional
213-744
3.80e-63
AMP deaminase; Provisional
Pssm-ID: 240354 [Multi-domain]
Cd Length: 1453
Bit Score: 230.85
E-value: 3.80e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 213 I PT FK EF RE D fewc L KII RD ---- RSLS R FSE KRL QY L VN KF PV fq HL --- HS K E ---- E M R Q S K kvp HK DFY NCR K I D L 281
Cdd:PTZ00310 779 L PT LT EF IR D ---- L SEL RD icss VEVK R LAT KRL EN L EH KF RL -- HL aln HS N E agtt E E R E S S --- NR DFY QAY K V D T 849
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 282 NLLLSGCFSQW QL T EF IWT KL RKEP D RVIHQ af N G S HI - TL S QLF KVNFEETGQFFNG L KIID D SF L EWYKVIYPA KY hl 360
Cdd:PTZ00310 850 HIHMAAGMTAR QL L EF VVD KL LESG D DIAFK -- R G D HI v TL G QLF SKYGITPNLTVDQ L NVQA D HT L FERFDNFNS KY -- 925
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 361 vn DE ME ihtgs HG k Q LR yylia KTF L EF DN YIN G E Y L AEL L K - T F LIKPQEESK Y QLCQ LS V dfqfylh Y DNSDVD nw W M 439
Cdd:PTZ00310 926 -- NP ME ----- NP - D LR ----- SLL L KT DN FMK G R Y F AEL I K d V F EQYSRDRFT Y AENR LS I ------- Y GINVKE -- W D 983
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 440 VF A N W LNHYNIF S NNIR W N I RIS R I Y PELYHTGKVKN F QE YL NL IF K PL FN A E ny LH K S LG P ILLK FL SQ VS SI D l CI q D 519
Cdd:PTZ00310 984 DL A H W FDTHGMA S KHNK W M I QVP R V Y KVFRAQNVIGS F GQ YL DN IF Q PL WE A S -- LH P S KH P KFHY FL NH VS GF D - SV - D 1059
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 520 TDNY I WKN FT A VS cl P KD WTS G g D NP TISQ Y M YY V Y V N LTK LN HI R QALHQN TF T LR SS C SPT - SM nrtsqfsntlnft E 598
Cdd:PTZ00310 1060 NEAT I DLP FT D VS -- P WA WTS V - E NP PYNY Y L YY L Y A N IRT LN EF R ASRGFS TF A LR PH C GES g SM ------------- D 1123
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 599 H tet ILNN FL L A --- C G G F lnae NL W N A PP s LV YL F YL S QI PMV V A PL nsivd SN ptmlqeqap TG L V L E pskp YKK NPF 675
Cdd:PTZ00310 1124 H --- LYGA FL C A nsi C H G I ---- NL R N D PP - MQ YL Y YL A QI GLH V S PL ----- SN --------- NA L F L A ---- FLE NPF 1177
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 151946669 676 MK FF EM G FKI SLS SESI L YNN s Y T K EP I IEEYS V AA SIYR L HSA DLCE LL RNSV IT SGF SSTL K NKWL G 744
Cdd:PTZ00310 1178 PV FF HR G LNV SLS TDDP L MFH - Q T Q EP L IEEYS I AA RVWG L SLN DLCE IA RNSV LQ SGF DAAF K RNAI G 1245
PTZ00310
PTZ00310 AMP deaminase; Provisional
242-744
5.90e-34
AMP deaminase; Provisional
Pssm-ID: 240354 [Multi-domain]
Cd Length: 1453
Bit Score: 140.72
E-value: 5.90e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 242 RL QYLVNKFPV F QH L HSKE E M R QS kkv PH K D --- F YN C R K I D LNL LLS GCFSQWQ L T EF IW T KL R KE P DRVIHQA f N GS H 318
Cdd:PTZ00310 171 RL TIIQERSRM F FL L NAEI E E R AD --- LY K A ggv F SP C T K V D NAV LLS TSVDAQE L L EF VV T TY R EQ P RAPLRLR - D GS N 246
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 319 I TL SQLFKVN feetgqffn G LKIIDDSFL E --- W YKVI Y PA KY HLVN - DEMEIHT G SH G KQ LR Y yliak T FL EFDNYIN G 394
Cdd:PTZ00310 247 S TL REYLEAH --------- G VRDPRELTV E glg W QPTK Y RN KY GQYD l FDAKNPM G AL G AE LR Q ----- S FL SLHGNLC G 312
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 395 EY L AEL L KT flikp Q E ES K Y Q LCQLSVDFQF Y L H YDNSDV D nwwmv F A N W LNHYNI -- FS N N i RW NIR IS ri YP EL YHTG 472
Cdd:PTZ00310 313 KL L RRE L ER ----- R E YQ K Q Q PQATEYSLPL Y G H HPEELT D ----- L A E W VRRQGF gp FS R N - RW ILA IS -- FK EL GPFQ 379
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 473 KV --- KNF Q EY L NL IF K PLF N A ENYLHKSLGPILLKF L S QV SSID lc I QDTDNYIWKN F TAVSCL P k D WTSGGDNPTISQ 549
Cdd:PTZ00310 380 VP ssc TTV Q DQ L DN IF L PLF K A TLCPSDPQWSDVAWL L C QV GGLQ -- I LTHAVVRSED F DETAPD P - D QVPYTAKCSDLY 456
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 550 Y M YYVY V NL TK LN HI R QALHQ NT FT LR S S CS - PTSMNR tsqfsntlnftehtet ILNNF LL ac G GFLNAENLWNAP P S L V 628
Cdd:PTZ00310 457 Y F YYVY A NL AV LN SL R KRKGL NT LQ LR P S GE k APAYDQ ---------------- LISSY LL -- G DVITRATSIADY P V L Q 518
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151946669 629 YL FY L SQIPMV V A PL NSIVD S nptmlqeqaptglvlep SKP Y KKN P FM KF FEMGFKI S L S SESI LY NN s YTKE P I IEEY S 708
Cdd:PTZ00310 519 YL CG L HRVGLT V S PL RDHAL S ----------------- ITA Y FDH P LP KF LHRCLRV S I S TSDP LY FH - HHSQ P L IEEY A 580
490 500 510
....*....|....*....|....*....|....*.
gi 151946669 709 V A ASIYR L HSA D LC EL L RNSV IT S G F SSTL K NK WLG 744
Cdd:PTZ00310 581 T A MKLFS L SPL D TT EL A RNSV LN S S F PPEV K QQ WLG 616
ADA
cd01320 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the ...
668-743
6.13e-03
Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in the purine pathway. Low, as well as high levels of ADA activity have been linked to several diseases.
Pssm-ID: 238645
Cd Length: 325
Bit Score: 39.49
E-value: 6.13e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 151946669 668 K PYKKN P FMKFFEM G F K ISLSSESILYNNS Y tkep IIE EY SVA A SIYR L HSAD L CE L L RN S V IT S GF S STL K NKW L 743
Cdd:cd01320 251 K SLAEH P LRELLDA G V K VTINTDDPTVFGT Y ---- LTD EY ELL A EAFG L TEEE L KK L A RN A V EA S FL S EEE K AEL L 322
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
