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Conserved domains on  [gi|1519109963|gb|AYZ89486|]
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ATP-binding protein [Bifidobacterium breve]

Protein Classification

ATP-binding protein( domain architecture ID 13694361)

ATPase similar to histidine kinase domains and containing a PspC domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
204-419 1.02e-35

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


:

Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 132.05  E-value: 1.02e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963 204 MLSGFIMIACIVLAVMPWA----NAMLQRLSREQALKEREEERADMTAHLHDGVLQTLALIQLHSE--------DP---- 267
Cdd:COG4585    12 LLVGALLGLLLALVLLRARraerAAELERELAARAEEAREEERRRIARELHDGVGQSLSAIKLQLEaarrlldaDPeaar 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963 268 ---ATVFTLARGQERELREWLYQERST--SDRSVSAGLKQIAAEVEDEHGKPIEVVTVGDAH--PSAQTDALLDATRQAL 340
Cdd:COG4585    92 eelEEIRELAREALAELRRLVRGLRPPalDDLGLAAALEELAERLLRAAGIRVELDVDGDPDrlPPEVELALYRIVQEAL 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963 341 VNAVTH-GSEPISLYCEATDTTVEVFVRDHGEGFDIDTIPPDRLGIReSIIGRIKRRGGTVEIVSRAGWGTEVRMHMPIA 419
Cdd:COG4585   172 TNALKHaGATRVTVTLEVDDGELTLTVRDDGVGFDPEAAPGGGLGLR-GMRERAEALGGTLTIGSAPGGGTRVRATLPLA 250
PspC COG1983
Phage shock protein PspC (stress-responsive transcriptional regulator) [Transcription, Signal ...
 12-74 3.44e-22

Phage shock protein PspC (stress-responsive transcriptional regulator) [Transcription, Signal transduction mechanisms];


:

Pssm-ID: 441586 [Multi-domain]  Cd Length: 65  Bit Score: 89.44  E-value: 3.44e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1519109963  12 RMPLTRPKRGRWLTGVCKGIALHLGISVMWVRLAFIALTCLYGAGIIAYVFLWIFMPAGDPQA 74
Cdd:COG1983     1 RKKLYRSRDDRVIAGVCAGLAEYFGIDPTLVRLIFVLLTLFGGAGILLYLILWLLLPEAPTAA 63
 
Name Accession Description Interval E-value
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
204-419 1.02e-35

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 132.05  E-value: 1.02e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963 204 MLSGFIMIACIVLAVMPWA----NAMLQRLSREQALKEREEERADMTAHLHDGVLQTLALIQLHSE--------DP---- 267
Cdd:COG4585    12 LLVGALLGLLLALVLLRARraerAAELERELAARAEEAREEERRRIARELHDGVGQSLSAIKLQLEaarrlldaDPeaar 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963 268 ---ATVFTLARGQERELREWLYQERST--SDRSVSAGLKQIAAEVEDEHGKPIEVVTVGDAH--PSAQTDALLDATRQAL 340
Cdd:COG4585    92 eelEEIRELAREALAELRRLVRGLRPPalDDLGLAAALEELAERLLRAAGIRVELDVDGDPDrlPPEVELALYRIVQEAL 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963 341 VNAVTH-GSEPISLYCEATDTTVEVFVRDHGEGFDIDTIPPDRLGIReSIIGRIKRRGGTVEIVSRAGWGTEVRMHMPIA 419
Cdd:COG4585   172 TNALKHaGATRVTVTLEVDDGELTLTVRDDGVGFDPEAAPGGGLGLR-GMRERAEALGGTLTIGSAPGGGTRVRATLPLA 250
PspC COG1983
Phage shock protein PspC (stress-responsive transcriptional regulator) [Transcription, Signal ...
 12-74 3.44e-22

Phage shock protein PspC (stress-responsive transcriptional regulator) [Transcription, Signal transduction mechanisms];


Pssm-ID: 441586 [Multi-domain]  Cd Length: 65  Bit Score: 89.44  E-value: 3.44e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1519109963  12 RMPLTRPKRGRWLTGVCKGIALHLGISVMWVRLAFIALTCLYGAGIIAYVFLWIFMPAGDPQA 74
Cdd:COG1983     1 RKKLYRSRDDRVIAGVCAGLAEYFGIDPTLVRLIFVLLTLFGGAGILLYLILWLLLPEAPTAA 63
PspC pfam04024
PspC domain; This family includes Phage shock protein C (PspC) that is thought to be a ...
 14-68 2.88e-21

PspC domain; This family includes Phage shock protein C (PspC) that is thought to be a transcriptional regulator. The presumed domain is 60 amino acid residues in length.


Pssm-ID: 461134  Cd Length: 57  Bit Score: 86.33  E-value: 2.88e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1519109963  14 PLTRPKRGRWLTGVCKGIALHLGISVMWVRLAFIALTCLYGAGIIAYVFLWIFMP 68
Cdd:pfam04024   2 KLYRSRDDRMIAGVCGGLAEYFGIDPTLVRLLFVLLALFGGGGILLYIILWLLIP 56
phageshock_pspC TIGR02978
phage shock protein C; All members of this protein family are the phage shock protein PspC. ...
 15-97 1.58e-10

phage shock protein C; All members of this protein family are the phage shock protein PspC. These proteins contain a PspC domain, as do other members of the larger family of proteins described by pfam04024. The phage shock regulon is restricted to the Proteobacteria and somewhat sparsely distributed there. It is expressed, under positive control of a sigma-54-dependent transcription factor, PspF, which binds and is modulated by PspA. Stresses that induce the psp regulon include phage secretin overexpression, ethanol, heat shock, and protein export defects. [Cellular processes, Adaptations to atypical conditions]


Pssm-ID: 132023  Cd Length: 121  Bit Score: 58.42  E-value: 1.58e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963  15 LTRPKRGRWLTGVCKGIALHLGISVMWVRLAFIALTCLYGAG--IIAYVFLWIFMpagDPQAVASAEHIPVEQAPLARGN 92
Cdd:TIGR02978   4 LYRDPQNGKIAGVCAGLADYFGVEVWLVRILVVSALLFGGGFfvLVAYIALWLLL---DKKPINLYEDDDVKSKPWQAGQ 80


                  ....*
gi 1519109963  93 QPAQA 97
Cdd:TIGR02978  81 SPRQA 85
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 337-417 9.22e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 52.17  E-value: 9.22e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963 337 RQALVNAVTH-GSEPISLYCEATDTTVEVFVRDHGEGFDIDTIPPDR----LGIREsiigRIKRRGGTVEIVSRAGWGTE 411
Cdd:cd16917     6 QEALTNALKHaGASRVRVTLSYTADELTLTVVDDGVGFDGPAPPGGGgfglLGMRE----RAELLGGTLTIGSRPGGGTR 81


                  ....*.
gi 1519109963 412 VRMHMP 417
Cdd:cd16917    82 VTARLP 87
HATPase_c_2 pfam13581
Histidine kinase-like ATPase domain;
325-414 8.56e-07

Histidine kinase-like ATPase domain;


Pssm-ID: 433327 [Multi-domain]  Cd Length: 127  Bit Score: 47.67  E-value: 8.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963 325 PSAQTDALLDATRQALVNAVTHG-----SEPISLYCEATDTTVEVFVRDHGEGFDIDTIPPDRLgirESIIGRIKRRG-G 398
Cdd:pfam13581  25 PEELLDEVELAVGEACTNAVEHAyregpEGPVEVRLTSDGGGLVVTVADSGPPFDPLTLPPPDL---EEPDEDRKEGGrG 101

                          90       100
                  ....*....|....*....|....*
gi 1519109963 399 ---------TVEIVSRAGwGTEVRM 414
Cdd:pfam13581 102 lalirglmdDVEYTRGGE-GNTVRM 125
PRK10935 PRK10935
nitrate/nitrite two-component system sensor histidine kinase NarQ;
225-417 2.49e-06

nitrate/nitrite two-component system sensor histidine kinase NarQ;


Pssm-ID: 236800 [Multi-domain]  Cd Length: 565  Bit Score: 49.47  E-value: 2.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963 225 MLQR-LSREQALKERE-----EERADMTAHLHDGVLQTLAL--IQL----HSEDPATVFTLARGQE---------RELRE 283
Cdd:PRK10935  341 MLGRgLYFNQAQKQQQqlllmEERATIARELHDSLAQVLSYlkIQLtllkRSLDEDNAKAQSIIAEfdqalsdayRQLRE 420

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963 284 WLYQERST-SDRSVSAGLKQIAAEVEDEHGKPIEVvtvgDAHPSAQT-DA-----LLDATRQALVNAVTH--GSEPISLY 354
Cdd:PRK10935  421 LLTTFRLTiQEANLGSALEEMLDQLRNQTDAKITL----DCRLPSQAlDAqqqvhLLQIIREATLNAIKHanASEIAVSC 496

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1519109963 355 CEATDTTVEVFVRDHGEGFDIDTIPPDRLGI---REsiigRIKRRGGTVEIVSRAGWGTEVRMHMP 417
Cdd:PRK10935  497 VTNPDGEHTVSIRDDGIGIGELKEPEGHYGLnimQE----RAERLGGTLTISQPPGGGTTVSLTFP 558
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 339-419 3.27e-04

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 39.94  E-value: 3.27e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963  339 ALVNAVTHGSE--PISLYCEATDTTVEVFVRDHGEGFDIDTI-----PPDRLGIRESIIG-----------RIKRRGGTV 400
Cdd:smart00387  13 LLDNAIKYTPEggRITVTLERDGDHVEITVEDNGPGIPPEDLekifePFFRTDKRSRKIGgtglglsivkkLVELHGGEI 92

                           90
                   ....*....|....*....
gi 1519109963  401 EIVSRAGWGTEVRMHMPIA 419
Cdd:smart00387  93 SVESEPGGGTTFTITLPLE 111
PRK10697 PRK10697
envelope stress response membrane protein PspC;
18-98 5.37e-03

envelope stress response membrane protein PspC;


Pssm-ID: 182656  Cd Length: 118  Bit Score: 36.85  E-value: 5.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963  18 PKRGRwLTGVCKGIALHLGISVMWVR-LAFIALTC-LYGAGIIAYVFLWIFM-PAgdPQAVASAEHIPVEQAPLARGNQP 94
Cdd:PRK10697   13 PQQGM-VKGVCAGIAHYFDVPVKLVRiIVVLSIFFgLFVFTLVAYIILSFALdPM--PDNMAFGEQQPSSSELLDEVDRE 89


                  ....
gi 1519109963  95 AQAG 98
Cdd:PRK10697   90 LAAG 93
 
Name Accession Description Interval E-value
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
204-419 1.02e-35

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 132.05  E-value: 1.02e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963 204 MLSGFIMIACIVLAVMPWA----NAMLQRLSREQALKEREEERADMTAHLHDGVLQTLALIQLHSE--------DP---- 267
Cdd:COG4585    12 LLVGALLGLLLALVLLRARraerAAELERELAARAEEAREEERRRIARELHDGVGQSLSAIKLQLEaarrlldaDPeaar 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963 268 ---ATVFTLARGQERELREWLYQERST--SDRSVSAGLKQIAAEVEDEHGKPIEVVTVGDAH--PSAQTDALLDATRQAL 340
Cdd:COG4585    92 eelEEIRELAREALAELRRLVRGLRPPalDDLGLAAALEELAERLLRAAGIRVELDVDGDPDrlPPEVELALYRIVQEAL 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963 341 VNAVTH-GSEPISLYCEATDTTVEVFVRDHGEGFDIDTIPPDRLGIReSIIGRIKRRGGTVEIVSRAGWGTEVRMHMPIA 419
Cdd:COG4585   172 TNALKHaGATRVTVTLEVDDGELTLTVRDDGVGFDPEAAPGGGLGLR-GMRERAEALGGTLTIGSAPGGGTRVRATLPLA 250
PspC COG1983
Phage shock protein PspC (stress-responsive transcriptional regulator) [Transcription, Signal ...
 12-74 3.44e-22

Phage shock protein PspC (stress-responsive transcriptional regulator) [Transcription, Signal transduction mechanisms];


Pssm-ID: 441586 [Multi-domain]  Cd Length: 65  Bit Score: 89.44  E-value: 3.44e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1519109963  12 RMPLTRPKRGRWLTGVCKGIALHLGISVMWVRLAFIALTCLYGAGIIAYVFLWIFMPAGDPQA 74
Cdd:COG1983     1 RKKLYRSRDDRVIAGVCAGLAEYFGIDPTLVRLIFVLLTLFGGAGILLYLILWLLLPEAPTAA 63
PspC pfam04024
PspC domain; This family includes Phage shock protein C (PspC) that is thought to be a ...
 14-68 2.88e-21

PspC domain; This family includes Phage shock protein C (PspC) that is thought to be a transcriptional regulator. The presumed domain is 60 amino acid residues in length.


Pssm-ID: 461134  Cd Length: 57  Bit Score: 86.33  E-value: 2.88e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1519109963  14 PLTRPKRGRWLTGVCKGIALHLGISVMWVRLAFIALTCLYGAGIIAYVFLWIFMP 68
Cdd:pfam04024   2 KLYRSRDDRMIAGVCGGLAEYFGIDPTLVRLLFVLLALFGGGGILLYIILWLLIP 56
phageshock_pspC TIGR02978
phage shock protein C; All members of this protein family are the phage shock protein PspC. ...
 15-97 1.58e-10

phage shock protein C; All members of this protein family are the phage shock protein PspC. These proteins contain a PspC domain, as do other members of the larger family of proteins described by pfam04024. The phage shock regulon is restricted to the Proteobacteria and somewhat sparsely distributed there. It is expressed, under positive control of a sigma-54-dependent transcription factor, PspF, which binds and is modulated by PspA. Stresses that induce the psp regulon include phage secretin overexpression, ethanol, heat shock, and protein export defects. [Cellular processes, Adaptations to atypical conditions]


Pssm-ID: 132023  Cd Length: 121  Bit Score: 58.42  E-value: 1.58e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963  15 LTRPKRGRWLTGVCKGIALHLGISVMWVRLAFIALTCLYGAG--IIAYVFLWIFMpagDPQAVASAEHIPVEQAPLARGN 92
Cdd:TIGR02978   4 LYRDPQNGKIAGVCAGLADYFGVEVWLVRILVVSALLFGGGFfvLVAYIALWLLL---DKKPINLYEDDDVKSKPWQAGQ 80


                  ....*
gi 1519109963  93 QPAQA 97
Cdd:TIGR02978  81 SPRQA 85
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
224-419 7.71e-09

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 56.07  E-value: 7.71e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963 224 AMLQRLSREQALkeREEERADMTAHLHDGVLQTLALIQlhsedpaTVFTLARGQEREL---REWLyqerstsdrSVSAGL 300
Cdd:COG2205    36 GAAELLLDEEDL--SPEERRELLEIIRESAERLLRLIE-------DLLDLSRLESGKLsleLEPV---------DLAELL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963 301 KQIAAEVE---DEHGKPIEVvTVGDAHPSAQTDALLdaTRQALV----NAVTHGSE--PISLYCEATDTTVEVFVRDHGE 371
Cdd:COG2205    98 EEAVEELRplaEEKGIRLEL-DLPPELPLVYADPEL--LEQVLAnlldNAIKYSPPggTITISARREGDGVRISVSDNGP 174

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1519109963 372 GfdidtIPPD----------RLGIRESIIGR----------IKRRGGTVEIVSRAGWGTEVRMHMPIA 419
Cdd:COG2205   175 G-----IPEEeleriferfyRGDNSRGEGGTglglaivkriVEAHGGTIWVESEPGGGTTFTVTLPLA 237
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 337-417 9.22e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 52.17  E-value: 9.22e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963 337 RQALVNAVTH-GSEPISLYCEATDTTVEVFVRDHGEGFDIDTIPPDR----LGIREsiigRIKRRGGTVEIVSRAGWGTE 411
Cdd:cd16917     6 QEALTNALKHaGASRVRVTLSYTADELTLTVVDDGVGFDGPAPPGGGgfglLGMRE----RAELLGGTLTIGSRPGGGTR 81


                  ....*.
gi 1519109963 412 VRMHMP 417
Cdd:cd16917    82 VTARLP 87
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
325-418 1.67e-07

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 49.91  E-value: 1.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963 325 PSAQTDALLdATRQALVNAVTHG-----SEPISLYCEATDTTVEVFVRDHGEGFDIDTIPPDRLGIRESiiGR----IKR 395
Cdd:COG2172    29 EDDADDLVL-AVSEAVTNAVRHAyggdpDGPVEVELELDPDGLEIEVRDEGPGFDPEDLPDPYSTLAEG--GRglflIRR 105

                          90       100
                  ....*....|....*....|...
gi 1519109963 396 RGGTVEIVSRAGwGTEVRMHMPI 418
Cdd:COG2172   106 LMDEVEYESDPG-GTTVRLVKRL 127
HATPase_c_2 pfam13581
Histidine kinase-like ATPase domain;
325-414 8.56e-07

Histidine kinase-like ATPase domain;


Pssm-ID: 433327 [Multi-domain]  Cd Length: 127  Bit Score: 47.67  E-value: 8.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963 325 PSAQTDALLDATRQALVNAVTHG-----SEPISLYCEATDTTVEVFVRDHGEGFDIDTIPPDRLgirESIIGRIKRRG-G 398
Cdd:pfam13581  25 PEELLDEVELAVGEACTNAVEHAyregpEGPVEVRLTSDGGGLVVTVADSGPPFDPLTLPPPDL---EEPDEDRKEGGrG 101

                          90       100
                  ....*....|....*....|....*
gi 1519109963 399 ---------TVEIVSRAGwGTEVRM 414
Cdd:pfam13581 102 lalirglmdDVEYTRGGE-GNTVRM 125
PRK10935 PRK10935
nitrate/nitrite two-component system sensor histidine kinase NarQ;
225-417 2.49e-06

nitrate/nitrite two-component system sensor histidine kinase NarQ;


Pssm-ID: 236800 [Multi-domain]  Cd Length: 565  Bit Score: 49.47  E-value: 2.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963 225 MLQR-LSREQALKERE-----EERADMTAHLHDGVLQTLAL--IQL----HSEDPATVFTLARGQE---------RELRE 283
Cdd:PRK10935  341 MLGRgLYFNQAQKQQQqlllmEERATIARELHDSLAQVLSYlkIQLtllkRSLDEDNAKAQSIIAEfdqalsdayRQLRE 420

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963 284 WLYQERST-SDRSVSAGLKQIAAEVEDEHGKPIEVvtvgDAHPSAQT-DA-----LLDATRQALVNAVTH--GSEPISLY 354
Cdd:PRK10935  421 LLTTFRLTiQEANLGSALEEMLDQLRNQTDAKITL----DCRLPSQAlDAqqqvhLLQIIREATLNAIKHanASEIAVSC 496

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1519109963 355 CEATDTTVEVFVRDHGEGFDIDTIPPDRLGI---REsiigRIKRRGGTVEIVSRAGWGTEVRMHMP 417
Cdd:PRK10935  497 VTNPDGEHTVSIRDDGIGIGELKEPEGHYGLnimQE----RAERLGGTLTISQPPGGGTTVSLTFP 558
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
226-419 2.56e-06

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 49.14  E-value: 2.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963 226 LQRLSREQALKEREEERADMTAHL-HDgvLQT-LALIQLHSEdpatvfTLARGQERELREWLYQERSTSDR--------- 294
Cdd:COG0642    94 LLLLALLLLLEEANEAKSRFLANVsHE--LRTpLTAIRGYLE------LLLEELDEEQREYLETILRSADRllrlindll 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963 295 ---SVSAG----------LKQIAAEVEDE-----HGKPIEV-VTVGDAHPSAQTDAllDATRQALV----NAVTHGSE-- 349
Cdd:COG0642   166 dlsRLEAGklelepepvdLAELLEEVVELfrplaEEKGIELeLDLPDDLPTVRGDP--DRLRQVLLnllsNAIKYTPEgg 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963 350 PISLYCEATDTTVEVFVRDHGEGfdidtIPPDRL-------------------GIRESIIGRI-KRRGGTVEIVSRAGWG 409
Cdd:COG0642   244 TVTVSVRREGDRVRISVEDTGPG-----IPPEDLerifepffrtdpsrrgggtGLGLAIVKRIvELHGGTIEVESEPGKG 318

                         250
                  ....*....|
gi 1519109963 410 TEVRMHMPIA 419
Cdd:COG0642   319 TTFTVTLPLA 328
HATPase_RsbW-like cd16936
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ...
 339-416 2.21e-05

Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.


Pssm-ID: 340413 [Multi-domain]  Cd Length: 91  Bit Score: 42.64  E-value: 2.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963 339 ALVNAVTHG-----SEPISLYCEATDTTVEVFVRDHGEGFDIDTIPPDRLGIRESiiGR----IKRRGGTVEIVSRAGwG 409
Cdd:cd16936     8 AVTNAVRHAyrhdgPGPVRLELDLDPDRLRVEVTDSGPGFDPLRPADPDAGLREG--GRglalIRALMDEVGYRRTPG-G 84


                  ....*..
gi 1519109963 410 TEVRMHM 416
Cdd:cd16936    85 KTVWLEL 91
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 31-419 2.28e-05

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 46.44  E-value: 2.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963  31 IALHLGISVMWVRLAFIALTCLYGAGIIAYVFLWIFMPAGDPQAVASAEHIPVEQAPLARGNQPAQAGVEDTAVSAESLS 110
Cdd:COG3920    82 LALLVLLLLLLLAAAALALALLLAALAGLLLLAALLLLRLVALLAALALLALLLLLLLLLAILALAELAVALAELAAALL 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963 111 EAIQRAPKPALVALAGFVLLTIGLLLVGTGADSQLIIPLLLGLAGIALAWMNLSPNGTQLLSMLGGIALIFMGWAIYVSN 190
Cdd:COG3920   162 LLAEELAALRLAAAALLLLLAALLDLGLALAALAAAALLALLLALELLLALLLLLLLLLALLLVLLAALLRLRAAVLEEL 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963 191 VTYVGWGTSPRRIMLSGFIMIACIVLAVMPWANAML--QRLSREQALKEREEERADMTAHLHDGV---LQTL-ALIQL-- 262
Cdd:COG3920   242 ERRRRARGLGRLLLLLLLLLLLLRALLLLAAGIRLVitERKRAEEELEASLEEKELLLRELHHRVknnLQVVsSLLRLqa 321

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963 263 -HSEDPAT----------VFTLARGQERelrewLYQERSTSDRSVSAGLKQIAAEVEDEHG-KPIEVVTVGDahpsaqtD 330
Cdd:COG3920   322 rRADDPEArealeesqnrIQALALVHEL-----LYQSEDWEGVDLRDYLRELLEPLRDSYGgRGIRIELDGP-------D 389

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963 331 ALLDAtRQA----------LVNAVTHGSEP-----ISLYCEATDTTVEVFVRDHGEGFDIDTIPPDR--LGIR--ESIIG 391
Cdd:COG3920   390 VELPA-DAAvplglilnelVTNALKHAFLSgeggrIRVSWRREDGRLRLTVSDNGVGLPEDVDPPARkgLGLRliRALVR 468

                         410       420
                  ....*....|....*....|....*...
gi 1519109963 392 RIkrrGGTVEIVSRAgwGTEVRMHMPIA 419
Cdd:COG3920   469 QL---GGTLELDRPE--GTRVRITFPLA 491
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 339-419 3.27e-04

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 39.94  E-value: 3.27e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963  339 ALVNAVTHGSE--PISLYCEATDTTVEVFVRDHGEGFDIDTI-----PPDRLGIRESIIG-----------RIKRRGGTV 400
Cdd:smart00387  13 LLDNAIKYTPEggRITVTLERDGDHVEITVEDNGPGIPPEDLekifePFFRTDKRSRKIGgtglglsivkkLVELHGGEI 92

                           90
                   ....*....|....*....
gi 1519109963  401 EIVSRAGWGTEVRMHMPIA 419
Cdd:smart00387  93 SVESEPGGGTTFTITLPLE 111
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 330-419 4.62e-04

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 39.66  E-value: 4.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963 330 DALLDATRQALVNAVTHGSEPISLYCEAT-DTTVEVFVRDHGEGFDIDTIPP-----DRLGIRE--------SIIGRIKR 395
Cdd:pfam02518   4 LRLRQVLSNLLDNALKHAAKAGEITVTLSeGGELTLTVEDNGIGIPPEDLPRifepfSTADKRGgggtglglSIVRKLVE 83

                          90       100
                  ....*....|....*....|....*
gi 1519109963 396 R-GGTVEIVSRAGWGTEVRMHMPIA 419
Cdd:pfam02518  84 LlGGTITVESEPGGGTTVTLTLPLA 108
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
338-418 6.50e-04

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 41.93  E-value: 6.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963 338 QALV-NAVTHGSEP------ISLYCEATDTTVEVFVRDHGEGFDIDTIPPDRLGIRESIIGR------IKRR-------G 397
Cdd:COG2972   342 QPLVeNAIEHGIEPkegggtIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEELSSKGEGRgiglrnVRERlklyygeE 421

                          90       100
                  ....*....|....*....|.
gi 1519109963 398 GTVEIVSRAGWGTEVRMHMPI 418
Cdd:COG2972   422 YGLEIESEPGEGTTVTIRIPL 442
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 300-419 1.02e-03

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 41.10  E-value: 1.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963 300 LKQIAAEVEDEHGKP-IEVVT-VGDAHPSAQTDAllDATRQALVN-------AVTHGSEpISLYCEATDTTVEVFVRDHG 370
Cdd:COG5000   282 LREVLALYEPALKEKdIRLELdLDPDLPEVLADR--DQLEQVLINllknaieAIEEGGE-IEVSTRREDGRVRIEVSDNG 358

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1519109963 371 EGFDIDTIppDRL------------GIRESIIGRIKRR-GGTVEIVSRAGWGTEVRMHMPIA 419
Cdd:COG5000   359 PGIPEEVL--ERIfepffttkpkgtGLGLAIVKKIVEEhGGTIELESRPGGGTTFTIRLPLA 418
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 337-419 1.08e-03

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 40.94  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963 337 RQALVN-------AVTHGSEP-ISLYCEATDTTVEVFVRDHGEGfdidtIPPDrlgIRESI---------IGR------- 392
Cdd:COG4191   258 EQVLLNllinaidAMEEGEGGrITISTRREGDYVVISVRDNGPG-----IPPE---VLERIfepffttkpVGKgtglgls 329

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1519109963 393 -----IKRRGGTVEIVSRAGWGTEVRMHMPIA 419
Cdd:COG4191   330 isygiVEKHGGRIEVESEPGGGTTFTITLPLA 361
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
234-419 1.55e-03

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 40.69  E-value: 1.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963 234 ALKEREEERADMTAHL-HDgvLQT-LALIQLHSEdpatvfTLARGQER---ELREWLYQERSTSDR------------SV 296
Cdd:COG5002   157 ELERLEQMRREFVANVsHE--LRTpLTSIRGYLE------LLLDGAADdpeERREYLEIILEEAERlsrlvndlldlsRL 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963 297 SAG----------LKQIAAEVEDE-----HGKPIEV-VTVGDAHPSAQTDAllDATRQALV----NAVTHGSE--PISLY 354
Cdd:COG5002   229 ESGelklekepvdLAELLEEVVEElrplaEEKGIELeLDLPEDPLLVLGDP--DRLEQVLTnlldNAIKYTPEggTITVS 306

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963 355 CEATDTTVEVFVRDHGEGfdidtIPP-------DR----------------LG--IRESIigrIKRRGGTVEIVSRAGWG 409
Cdd:COG5002   307 LREEDDQVRISVRDTGIG-----IPEedlprifERfyrvdksrsretggtgLGlaIVKHI---VEAHGGRIWVESEPGKG 378

                         250
                  ....*....|
gi 1519109963 410 TEVRMHMPIA 419
Cdd:COG5002   379 TTFTITLPLA 388
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 300-419 4.34e-03

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 39.38  E-value: 4.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963 300 LKQIAAEVEDEHGKPIE----VVTVGDAhPSAQTDALLdaTRQALV----NAVTHGSEP----ISLYCEATDTTVEVFVR 367
Cdd:COG4251   358 LNELLEEVLEDLEPRIEergaEIEVGPL-PTVRGDPTL--LRQVFQnlisNAIKYSRPGepprIEIGAEREGGEWVFSVR 434

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1519109963 368 DHGEGFDI---DTI--PPDRLGIRESI----IG-----RI-KRRGGTVEIVSRAGWGTEVRMHMPIA 419
Cdd:COG4251   435 DNGIGIDPeyaEKIfeIFQRLHSRDEYegtgIGlaivkKIvERHGGRIWVESEPGEGATFYFTLPKA 501
PRK10697 PRK10697
envelope stress response membrane protein PspC;
18-98 5.37e-03

envelope stress response membrane protein PspC;


Pssm-ID: 182656  Cd Length: 118  Bit Score: 36.85  E-value: 5.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519109963  18 PKRGRwLTGVCKGIALHLGISVMWVR-LAFIALTC-LYGAGIIAYVFLWIFM-PAgdPQAVASAEHIPVEQAPLARGNQP 94
Cdd:PRK10697   13 PQQGM-VKGVCAGIAHYFDVPVKLVRiIVVLSIFFgLFVFTLVAYIILSFALdPM--PDNMAFGEQQPSSSELLDEVDRE 89


                  ....
gi 1519109963  95 AQAG 98
Cdd:PRK10697   90 LAAG 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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