NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1515191721|gb|ROL47338|]
View 

Protocadherin Fat 2 [Anabarilius grahami]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 11254427)

cadherin repeat domain-containing protein similar to cadherins, which are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2-68 1.53e-26

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 103.58  E-value: 1.53e-26
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1515191721    2 YSIVNGDPKQQFSIDPRTGHITVLSMLDREEITHYSLTVQAADEGSPPLSSAVQVTVTVSDVNDNPP 68
Cdd:smart00112  15 YSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 444-564 9.36e-21

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 89.02  E-value: 9.36e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1515191721 444 LKTSAEEGTVMSTNA--SDWGTLELVEKELWLRYSCGNmRPASMQVANHPVADGRWHDVSLEVNGTTLRLTIDSSHSNSV 521
Cdd:pfam02210   1 FRTRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGS-GPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1515191721 522 VLPQPCKLTQSGGAL----VLASSNPSTDAERLGFTGCLESLRFNGE 564
Cdd:pfam02210  80 LPPGESLLLNLNGPLylggLPPLLLLPALPVRAGFVGCIRDVRVNGE 126
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 76-166 8.82e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.06  E-value: 8.82e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1515191721  76 SLVLQEGEAVGSGILHLLVTDRDTPQNGPpFSFHIVSGNEDRSFYIDQ-GGLLSVSSPLRRRAKPQHLLKIQVTDSGHPP 154
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGENGE-VTYSIVSGNEDGLFSIDPsTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|..
gi 1515191721 155 LSSICVVKINIT 166
Cdd:cd11304    82 LSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 193-263 8.55e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 59.63  E-value: 8.55e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1515191721 193 VIGKLHATDQD--PQDILTYKLVSDAPDrGLFSVDAVDGKIVVEKDL---EPGLYHLNVSVSDG---KFSIWAEVKVHV 263
Cdd:cd11304    15 VVLTVSATDPDsgENGEVTYSIVSGNED-GLFSIDPSTGEITTAKPLdreEQSSYTLTVTATDGggpPLSSTATVTITV 92
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 591-628 2.57e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 2.57e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1515191721 591 DVKICAS-NPCENGGTCEeDSSGGFHCSCPLLYYGSRCE 628
Cdd:cd00054     1 DIDECASgNPCQNGGTCV-NTVGSYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2-68 1.53e-26

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 103.58  E-value: 1.53e-26
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1515191721    2 YSIVNGDPKQQFSIDPRTGHITVLSMLDREEITHYSLTVQAADEGSPPLSSAVQVTVTVSDVNDNPP 68
Cdd:smart00112  15 YSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2-66 1.66e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.24  E-value: 1.66e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1515191721   2 YSIVNGDPKQQFSIDPRTGHITVLSMLDREEITHYSLTVQAADEGSPPLSSAVQVTVTVSDVNDN 66
Cdd:cd11304    34 YSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 444-564 9.36e-21

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 89.02  E-value: 9.36e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1515191721 444 LKTSAEEGTVMSTNA--SDWGTLELVEKELWLRYSCGNmRPASMQVANHPVADGRWHDVSLEVNGTTLRLTIDSSHSNSV 521
Cdd:pfam02210   1 FRTRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGS-GPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1515191721 522 VLPQPCKLTQSGGAL----VLASSNPSTDAERLGFTGCLESLRFNGE 564
Cdd:pfam02210  80 LPPGESLLLNLNGPLylggLPPLLLLPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
439-564 1.09e-20

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 88.94  E-value: 1.09e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1515191721  439 HLSFRLKTSAEEGTVMST---NASDWGTLELVEKELWLRYSCGNmRPASMQVANHPVADGRWHDVSLEVNGTTLRLTIDS 515
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAgskGGGDYLALELRDGRLVLRYDLGS-GPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1515191721  516 SHSNSVVLPQPCKLTQSGGALVL----ASSNPSTDAERLGFTGCLESLRFNGE 564
Cdd:smart00282  80 GNRVSGESPGGLTILNLDGPLYLgglpEDLKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 416-562 4.71e-20

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 87.86  E-value: 4.71e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1515191721 416 AVRFDGKGYLKYlYQIEDGRENFHLSFRLKTSAEEGTVMST---NASDWGTLELVEKELWLRYSCGnmrPASMQV-ANHP 491
Cdd:cd00110     1 GVSFSGSSYVRL-PTLPAPRTRLSISFSFRTTSPNGLLLYAgsqNGGDFLALELEDGRLVLRYDLG---SGSLVLsSKTP 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1515191721 492 VADGRWHDVSLEVNGTTLRLTIDSSHSNSVVLPQPCKLTQSGGALVL----ASSNPSTDAERLGFTGCLESLRFN 562
Cdd:cd00110    77 LNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLgglpEDLKSPGLPVSPGFVGCIRDLKVN 151
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 76-166 8.82e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.06  E-value: 8.82e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1515191721  76 SLVLQEGEAVGSGILHLLVTDRDTPQNGPpFSFHIVSGNEDRSFYIDQ-GGLLSVSSPLRRRAKPQHLLKIQVTDSGHPP 154
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGENGE-VTYSIVSGNEDGLFSIDPsTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|..
gi 1515191721 155 LSSICVVKINIT 166
Cdd:cd11304    82 LSSTATVTITVL 93
Cadherin pfam00028
Cadherin domain;
2-60 3.91e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.12  E-value: 3.91e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1515191721   2 YSIVNGDPKQQFSIDPRTGHITVLSMLDREEITHYSLTVQAADEGSPPLSSAVQVTVTV 60
Cdd:pfam00028  33 YSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 94-173 4.40e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.92  E-value: 4.40e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1515191721   94 VTDRDTPQNGPpFSFHIVSGNEDRSFYIDQ-GGLLSVSSPLRRRAKPQHLLKIQVTDSGHPPLSSICVVKINITEQSRYP 172
Cdd:smart00112   2 ATDADSGENGK-VTYSILSGNDDGLFSIDPeTGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 1515191721  173 P 173
Cdd:smart00112  81 P 81
Cadherin pfam00028
Cadherin domain;
81-166 7.25e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.87  E-value: 7.25e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1515191721  81 EGEAVGSGILHLLVTDRDTPQNGPPFSFhIVSGNEDRSFYIDQ-GGLLSVSSPLRRRAKPQHLLKIQVTDSGHPPLSSIC 159
Cdd:pfam00028   7 ENAPVGTEVLTVTATDPDLGPNGRIFYS-ILGGGPGGNFRIDPdTGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTA 85


                  ....*..
gi 1515191721 160 VVKINIT 166
Cdd:pfam00028  86 TVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 193-263 8.55e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 59.63  E-value: 8.55e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1515191721 193 VIGKLHATDQD--PQDILTYKLVSDAPDrGLFSVDAVDGKIVVEKDL---EPGLYHLNVSVSDG---KFSIWAEVKVHV 263
Cdd:cd11304    15 VVLTVSATDPDsgENGEVTYSIVSGNED-GLFSIDPSTGEITTAKPLdreEQSSYTLTVTATDGggpPLSSTATVTITV 92
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 591-628 2.57e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 2.57e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1515191721 591 DVKICAS-NPCENGGTCEeDSSGGFHCSCPLLYYGSRCE 628
Cdd:cd00054     1 DIDECASgNPCQNGGTCV-NTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 595-626 3.74e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 44.30  E-value: 3.74e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1515191721 595 CASNPCENGGTCeEDSSGGFHCSCPLLYYGSR 626
Cdd:pfam00008   1 CAPNPCSNGGTC-VDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
595-628 5.59e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 5.59e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1515191721  595 CAS-NPCENGGTCeEDSSGGFHCSCPLLYY-GSRCE 628
Cdd:smart00179   5 CASgNPCQNGGTC-VNTVGSYRCECPPGYTdGRNCE 39
 
Name Accession Description Interval E-value
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2-68 1.53e-26

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 103.58  E-value: 1.53e-26
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1515191721    2 YSIVNGDPKQQFSIDPRTGHITVLSMLDREEITHYSLTVQAADEGSPPLSSAVQVTVTVSDVNDNPP 68
Cdd:smart00112  15 YSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2-66 1.66e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.24  E-value: 1.66e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1515191721   2 YSIVNGDPKQQFSIDPRTGHITVLSMLDREEITHYSLTVQAADEGSPPLSSAVQVTVTVSDVNDN 66
Cdd:cd11304    34 YSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 444-564 9.36e-21

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 89.02  E-value: 9.36e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1515191721 444 LKTSAEEGTVMSTNA--SDWGTLELVEKELWLRYSCGNmRPASMQVANHPVADGRWHDVSLEVNGTTLRLTIDSSHSNSV 521
Cdd:pfam02210   1 FRTRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGS-GPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1515191721 522 VLPQPCKLTQSGGAL----VLASSNPSTDAERLGFTGCLESLRFNGE 564
Cdd:pfam02210  80 LPPGESLLLNLNGPLylggLPPLLLLPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
439-564 1.09e-20

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 88.94  E-value: 1.09e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1515191721  439 HLSFRLKTSAEEGTVMST---NASDWGTLELVEKELWLRYSCGNmRPASMQVANHPVADGRWHDVSLEVNGTTLRLTIDS 515
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAgskGGGDYLALELRDGRLVLRYDLGS-GPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1515191721  516 SHSNSVVLPQPCKLTQSGGALVL----ASSNPSTDAERLGFTGCLESLRFNGE 564
Cdd:smart00282  80 GNRVSGESPGGLTILNLDGPLYLgglpEDLKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 416-562 4.71e-20

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 87.86  E-value: 4.71e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1515191721 416 AVRFDGKGYLKYlYQIEDGRENFHLSFRLKTSAEEGTVMST---NASDWGTLELVEKELWLRYSCGnmrPASMQV-ANHP 491
Cdd:cd00110     1 GVSFSGSSYVRL-PTLPAPRTRLSISFSFRTTSPNGLLLYAgsqNGGDFLALELEDGRLVLRYDLG---SGSLVLsSKTP 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1515191721 492 VADGRWHDVSLEVNGTTLRLTIDSSHSNSVVLPQPCKLTQSGGALVL----ASSNPSTDAERLGFTGCLESLRFN 562
Cdd:cd00110    77 LNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLgglpEDLKSPGLPVSPGFVGCIRDLKVN 151
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 76-166 8.82e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.06  E-value: 8.82e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1515191721  76 SLVLQEGEAVGSGILHLLVTDRDTPQNGPpFSFHIVSGNEDRSFYIDQ-GGLLSVSSPLRRRAKPQHLLKIQVTDSGHPP 154
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGENGE-VTYSIVSGNEDGLFSIDPsTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|..
gi 1515191721 155 LSSICVVKINIT 166
Cdd:cd11304    82 LSSTATVTITVL 93
Cadherin pfam00028
Cadherin domain;
2-60 3.91e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.12  E-value: 3.91e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1515191721   2 YSIVNGDPKQQFSIDPRTGHITVLSMLDREEITHYSLTVQAADEGSPPLSSAVQVTVTV 60
Cdd:pfam00028  33 YSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 94-173 4.40e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.92  E-value: 4.40e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1515191721   94 VTDRDTPQNGPpFSFHIVSGNEDRSFYIDQ-GGLLSVSSPLRRRAKPQHLLKIQVTDSGHPPLSSICVVKINITEQSRYP 172
Cdd:smart00112   2 ATDADSGENGK-VTYSILSGNDDGLFSIDPeTGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 1515191721  173 P 173
Cdd:smart00112  81 P 81
Cadherin pfam00028
Cadherin domain;
81-166 7.25e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.87  E-value: 7.25e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1515191721  81 EGEAVGSGILHLLVTDRDTPQNGPPFSFhIVSGNEDRSFYIDQ-GGLLSVSSPLRRRAKPQHLLKIQVTDSGHPPLSSIC 159
Cdd:pfam00028   7 ENAPVGTEVLTVTATDPDLGPNGRIFYS-ILGGGPGGNFRIDPdTGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTA 85


                  ....*..
gi 1515191721 160 VVKINIT 166
Cdd:pfam00028  86 TVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 193-263 8.55e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 59.63  E-value: 8.55e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1515191721 193 VIGKLHATDQD--PQDILTYKLVSDAPDrGLFSVDAVDGKIVVEKDL---EPGLYHLNVSVSDG---KFSIWAEVKVHV 263
Cdd:cd11304    15 VVLTVSATDPDsgENGEVTYSIVSGNED-GLFSIDPSTGEITTAKPLdreEQSSYTLTVTATDGggpPLSSTATVTITV 92
Laminin_G_1 pfam00054
Laminin G domain;
445-563 1.05e-08

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 54.63  E-value: 1.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1515191721 445 KTSAEEGTVMST---NASDWGTLELVEKELWLRYSCGNmRPASmQVANHPVADGRWHDVSLEVNGTTLRLTID------- 514
Cdd:pfam00054   2 RTTEPSGLLLYNgtqTERDFLALELRDGRLEVSYDLGS-GAAV-VRSGDKLNDGKWHSVELERNGRSGTLSVDgearptg 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1515191721 515 -SSHSNSVVLPQPCKLTqSGGALVLASSNPSTDAERlGFTGCLESLRFNG 563
Cdd:pfam00054  80 eSPLGATTDLDVDGPLY-VGGLPSLGVKKRRLAISP-SFDGCIRDVIVNG 127
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 591-628 2.57e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 2.57e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1515191721 591 DVKICAS-NPCENGGTCEeDSSGGFHCSCPLLYYGSRCE 628
Cdd:cd00054     1 DIDECASgNPCQNGGTCV-NTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 595-626 3.74e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 44.30  E-value: 3.74e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1515191721 595 CASNPCENGGTCeEDSSGGFHCSCPLLYYGSR 626
Cdd:pfam00008   1 CAPNPCSNGGTC-VDTPGGYTCICPEGYTGKR 31
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 6-66 8.38e-06

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 45.41  E-value: 8.38e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1515191721   6 NGDPKQQFSIDPRTGHITVLSMLDREEITHYSLTVQAADEGSPPLSSAVQVTVTVSDVNDN 66
Cdd:cd00031    38 KEALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVPQTSSVFSIEVYDENDN 98
EGF_CA smart00179
Calcium-binding EGF-like domain;
595-628 5.59e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 5.59e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1515191721  595 CAS-NPCENGGTCeEDSSGGFHCSCPLLYY-GSRCE 628
Cdd:smart00179   5 CASgNPCQNGGTC-VNTVGSYRCECPPGYTdGRNCE 39
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 595-628 1.15e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 40.15  E-value: 1.15e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1515191721 595 CA-SNPCENGGTCeEDSSGGFHCSCPLLYYGS-RCE 628
Cdd:cd00053     2 CAaSNPCSNGGTC-VNTPGSYRCVCPPGYTGDrSCE 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH