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Conserved domains on  [gi|1512432686|ref|NP_001354178|]
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X-linked retinitis pigmentosa GTPase regulator isoform H [Homo sapiens]

Protein Classification

RCC1 domain-containing protein( domain architecture ID 11474102)

RCC1 (regulator of chromosome condensation) domain-containing protein similar to Arabidopsis UVR8 (UV RESISTANCE LOCUS 8), which plays an important role in mediating the effects of UV-B radiation on pathogen resistance by controlling the expression of the sinapate biosynthetic pathway.

Gene Ontology:  GO:0003682|GO:0005085
PubMed:  9510255|18442486

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 38-359 4.47e-66

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 221.77  E-value: 4.47e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432686  38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALkpEKVKLAACGRNHTL-VSTGGNVYATGGNNEG 116
Cdd:COG5184     1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPGL--SNVVAVAAGGDHTCaLKADGTVWCWGNNSYG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432686 117 QLGLGDTEERNTFHVISFFTSehkIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIG-KPVSWIS 195
Cdd:COG5184    79 QLGDGTTTDRTTPVKVPGLTG---VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVDAGlSGVVAIA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432686 196 CGYYHSAFVTTDGELYVFGEPENGKLGLPNQllGNHRTPQLVSEIPEkVIQVACGGEHTVVLTEN-AVYTFGLGQFGQLG 274
Cdd:COG5184   156 AGGYHTCALKSDGTVWCWGANSYGQLGDGTT--TDRPTPVQVGGLSG-VVAVAAGGDHSCALKSDgTVWCWGSNSSGQLG 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432686 275 LGTFLFETSePKVIENIRDqtISYISCGENHT-ALITDiGLMYTFGDGRHGKLGLGleNFTNHFIPTLCSNFLRfiVKLV 353
Cdd:COG5184   233 DGTTTDRAT-PVQVAGLTG--VVAIAAGGSHTcALKSD-GTVWCWGDNSYGQLGDG--TTTDRSTPVKVPGLSG--VVAV 304


                  ....*.
gi 1512432686 354 ACGGCH 359
Cdd:COG5184   305 AAGSSH 310
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 38-359 4.47e-66

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 221.77  E-value: 4.47e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432686  38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALkpEKVKLAACGRNHTL-VSTGGNVYATGGNNEG 116
Cdd:COG5184     1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPGL--SNVVAVAAGGDHTCaLKADGTVWCWGNNSYG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432686 117 QLGLGDTEERNTFHVISFFTSehkIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIG-KPVSWIS 195
Cdd:COG5184    79 QLGDGTTTDRTTPVKVPGLTG---VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVDAGlSGVVAIA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432686 196 CGYYHSAFVTTDGELYVFGEPENGKLGLPNQllGNHRTPQLVSEIPEkVIQVACGGEHTVVLTEN-AVYTFGLGQFGQLG 274
Cdd:COG5184   156 AGGYHTCALKSDGTVWCWGANSYGQLGDGTT--TDRPTPVQVGGLSG-VVAVAAGGDHSCALKSDgTVWCWGSNSSGQLG 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432686 275 LGTFLFETSePKVIENIRDqtISYISCGENHT-ALITDiGLMYTFGDGRHGKLGLGleNFTNHFIPTLCSNFLRfiVKLV 353
Cdd:COG5184   233 DGTTTDRAT-PVQVAGLTG--VVAIAAGGSHTcALKSD-GTVWCWGDNSYGQLGDG--TTTDRSTPVKVPGLSG--VVAV 304


                  ....*.
gi 1512432686 354 ACGGCH 359
Cdd:COG5184   305 AAGSSH 310
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
157-204 6.47e-14

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 66.39  E-value: 6.47e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1512432686 157 DGRLFMWGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFV 204
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGlsGNKVVQVACGGDHTVAL 50
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 38-359 4.47e-66

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 221.77  E-value: 4.47e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432686  38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALkpEKVKLAACGRNHTL-VSTGGNVYATGGNNEG 116
Cdd:COG5184     1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPGL--SNVVAVAAGGDHTCaLKADGTVWCWGNNSYG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432686 117 QLGLGDTEERNTFHVISFFTSehkIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIG-KPVSWIS 195
Cdd:COG5184    79 QLGDGTTTDRTTPVKVPGLTG---VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVDAGlSGVVAIA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432686 196 CGYYHSAFVTTDGELYVFGEPENGKLGLPNQllGNHRTPQLVSEIPEkVIQVACGGEHTVVLTEN-AVYTFGLGQFGQLG 274
Cdd:COG5184   156 AGGYHTCALKSDGTVWCWGANSYGQLGDGTT--TDRPTPVQVGGLSG-VVAVAAGGDHSCALKSDgTVWCWGSNSSGQLG 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432686 275 LGTFLFETSePKVIENIRDqtISYISCGENHT-ALITDiGLMYTFGDGRHGKLGLGleNFTNHFIPTLCSNFLRfiVKLV 353
Cdd:COG5184   233 DGTTTDRAT-PVQVAGLTG--VVAIAAGGSHTcALKSD-GTVWCWGDNSYGQLGDG--TTTDRSTPVKVPGLSG--VVAV 304


                  ....*.
gi 1512432686 354 ACGGCH 359
Cdd:COG5184   305 AAGSSH 310
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 38-340 1.59e-64

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 217.54  E-value: 1.59e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432686  38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPekVKLAACGRNHTL-VSTGGNVYATGGNNEG 116
Cdd:COG5184    51 VAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRTTPVKVPGLTG--VVAVAAGYYHSCaLKSDGTVWCWGDNSSG 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432686 117 QLGLGDTEERNTFHVISffTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKPVSWISC 196
Cdd:COG5184   129 QLGDGTTTNRLTPVQVD--AGLSGVVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGLSGVVAVAA 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432686 197 GYYHSAFVTTDGELYVFGEPENGKLGLPNQllGNHRTPQLVSEiPEKVIQVACGGEHTVVLTEN-AVYTFGLGQFGQLGL 275
Cdd:COG5184   207 GGDHSCALKSDGTVWCWGSNSSGQLGDGTT--TDRATPVQVAG-LTGVVAIAAGGSHTCALKSDgTVWCWGDNSYGQLGD 283

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1512432686 276 GTFLFETSePKVIENIRDqtISYISCGENHT-ALITDiGLMYTFGDGRHGKLGLGleNFTNHFIPT 340
Cdd:COG5184   284 GTTTDRST-PVKVPGLSG--VVAVAAGSSHTcALLTD-GTVWCWGDNAYGQLGDG--TTTDRSTPV 343
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 37-128 3.61e-18

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 86.57  E-value: 3.61e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432686  37 PVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPekVKLAACGRNHTL-VSTGGNVYATGGNNE 115
Cdd:COG5184   251 VVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGLSG--VVAVAAGSSHTCaLLTDGTVWCWGDNAY 328

                          90
                  ....*....|...
gi 1512432686 116 GQLGLGDTEERNT 128
Cdd:COG5184   329 GQLGDGTTTDRST 341
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
157-204 6.47e-14

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 66.39  E-value: 6.47e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1512432686 157 DGRLFMWGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFV 204
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGlsGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
55-101 2.09e-12

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 62.15  E-value: 2.09e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1512432686  55 KLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLV 101
Cdd:pfam00415   3 RVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVA 49
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
262-309 2.34e-11

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 59.07  E-value: 2.34e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1512432686 262 VYTFGLGQFGQLGLGTFlFETSEPKVIENIRDQTISYISCGENHTALI 309
Cdd:pfam00415   4 VYTWGRNDYGQLGLGTT-ENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
207-257 4.25e-11

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 58.30  E-value: 4.25e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1512432686 207 DGELYVFGEPENGKLGLPNQLlgNHRTPQLVSEIPE-KVIQVACGGEHTVVL 257
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTE--NVLVPQKVEGLSGnKVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
141-170 1.18e-09

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 53.58  E-value: 1.18e-09
                          10        20        30
                  ....*....|....*....|....*....|
gi 1512432686 141 IKQLSAGSNTSAALTEDGRLFMWGDNSEGQ 170
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
105-154 2.23e-07

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 47.90  E-value: 2.23e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1512432686 105 GNVYATGGNNEGQLGLGDTEERNTFHVISFFtSEHKIKQLSAGSNTSAAL 154
Cdd:pfam00415   2 GRVYTWGRNDYGQLGLGTTENVLVPQKVEGL-SGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
313-359 2.32e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 44.82  E-value: 2.32e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1512432686 313 GLMYTFGDGRHGKLGLGleNFTNHFIPTLCSNFLRFIVKLVACGGCH 359
Cdd:pfam00415   2 GRVYTWGRNDYGQLGLG--TTENVLVPQKVEGLSGNKVVQVACGGDH 46
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
244-272 3.81e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 43.95  E-value: 3.81e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 1512432686 244 VIQVACGGEHTVVLTEN-AVYTFGLGQFGQ 272
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDgRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
38-66 9.02e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 42.80  E-value: 9.02e-06
                          10        20
                  ....*....|....*....|....*....
gi 1512432686  38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQ 66
Cdd:pfam13540   2 VSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
194-219 1.46e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 42.03  E-value: 1.46e-05
                          10        20
                  ....*....|....*....|....*.
gi 1512432686 194 ISCGYYHSAFVTTDGELYVFGEPENG 219
Cdd:pfam13540   4 VAAGDNHTLALTSDGRVYCWGDNSYG 29
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
89-117 5.22e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 40.49  E-value: 5.22e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 1512432686  89 VKLAACGRNHTLV-STGGNVYATGGNNEGQ 117
Cdd:pfam13540   1 VVSVAAGDNHTLAlTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
296-324 4.44e-04

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 37.79  E-value: 4.44e-04
                          10        20
                  ....*....|....*....|....*....
gi 1512432686 296 ISYISCGENHTALITDIGLMYTFGDGRHG 324
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYG 29
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
46-214 5.07e-03

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 39.37  E-value: 5.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432686  46 HSAVVTGNNKLYMFGSNNWGQlglGSKSAIskptcvkALKPEK---VKLAAC---GRNHT-LVSTGGNVYATGGNNEGQl 118
Cdd:COG3055    15 EAAAALLDGKVYVAGGLSGGS---ASNSFE-------VYDPATntwSELAPLpgpPRHHAaAVAQDGKLYVFGGFTGAN- 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1512432686 119 glGDTEERNTFHVISFFTSE-HKIKQLSAGSNTSAALTEDGRLFMWGdnseGQIGLKNVSNVCVPQQVTigkpVSWISCG 197
Cdd:COG3055    84 --PSSTPLNDVYVYDPATNTwTKLAPMPTPRGGATALLLDGKIYVVG----GWDDGGNVAWVEVYDPAT----GTWTQLA 153

                         170       180
                  ....*....|....*....|...
gi 1512432686 198 ------YYHSAFVTTDGELYVFG 214
Cdd:COG3055   154 plptprDHLAAAVLPDGKILVIG 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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