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Conserved domains on  [gi|15079201|ref|NP_149942|]
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NADH dehydrogenase subunit 6 (mitochondrion) [Trichosurus vulpecula]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009569)

NADH dehydrogenase subunit 6 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-166 7.14e-73

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 214421  Cd Length: 175  Bit Score: 216.59  E-value: 7.14e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15079201    1 MEMMVVFLFSVLFIFGFVAFASKPSPIYGGLSLVVSGGLGSAIVVSLENTFLGLVVFLVYLGGMLVVFGYTSAMATEEYP 80
Cdd:MTH00109   1 MMMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15079201   81 ESWVGNMVAFSMLLFTLFVELV---WYFMSGEVEVDTAVE------LFDTVGVYCVGQDSSGVSLLYGCGGWILVLLGWV 151
Cdd:MTH00109  81 ETWVSNKVVLGALLLGLLMELLlvlYVLKDDEVEVVFNFNglgdwvIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWS 160

                        170
                 ....*....|....*
gi 15079201  152 LFITIYIVLEIVRGR 166
Cdd:MTH00109 161 LFIGVFVIIEITRGN 175
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-166 7.14e-73

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 216.59  E-value: 7.14e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15079201    1 MEMMVVFLFSVLFIFGFVAFASKPSPIYGGLSLVVSGGLGSAIVVSLENTFLGLVVFLVYLGGMLVVFGYTSAMATEEYP 80
Cdd:MTH00109   1 MMMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15079201   81 ESWVGNMVAFSMLLFTLFVELV---WYFMSGEVEVDTAVE------LFDTVGVYCVGQDSSGVSLLYGCGGWILVLLGWV 151
Cdd:MTH00109  81 ETWVSNKVVLGALLLGLLMELLlvlYVLKDDEVEVVFNFNglgdwvIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWS 160

                        170
                 ....*....|....*
gi 15079201  152 LFITIYIVLEIVRGR 166
Cdd:MTH00109 161 LFIGVFVIIEITRGN 175
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
18-162 6.46e-10

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 54.43  E-value: 6.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15079201    18 VAFASKPSPIYGGLSLVVSGGLGSAIVVSLENTFLGLVVFLVYLGGMLVVFGYTSAMATEEYPESWVGN--MVAFSMLLF 95
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSglPLAALLLGL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15079201    96 TLFVELVWYFMSGEVEVDTAVELFDTVGVYCVGQdssgvsLLYGCGGWILVLLGWVLFITIYIVLEI 162
Cdd:pfam00499  81 LLLALLLLVLLSASLTPAAAAAAPDVGNIEAIGE------LLFTDYLLPFELASVLLLVALVGAIVL 141
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-166 7.14e-73

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 216.59  E-value: 7.14e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15079201    1 MEMMVVFLFSVLFIFGFVAFASKPSPIYGGLSLVVSGGLGSAIVVSLENTFLGLVVFLVYLGGMLVVFGYTSAMATEEYP 80
Cdd:MTH00109   1 MMMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15079201   81 ESWVGNMVAFSMLLFTLFVELV---WYFMSGEVEVDTAVE------LFDTVGVYCVGQDSSGVSLLYGCGGWILVLLGWV 151
Cdd:MTH00109  81 ETWVSNKVVLGALLLGLLMELLlvlYVLKDDEVEVVFNFNglgdwvIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWS 160

                        170
                 ....*....|....*
gi 15079201  152 LFITIYIVLEIVRGR 166
Cdd:MTH00109 161 LFIGVFVIIEITRGN 175
ND6 MTH00065
NADH dehydrogenase subunit 6; Provisional
 3-165 2.02e-38

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214415  Cd Length: 172  Bit Score: 128.81  E-value: 2.02e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15079201    3 MMVVFLFSVLFIFGFVAFASKPSPIYGGLSLVVSGGLGSAIVVSLENTFLGLVVFLVYLGGMLVVFGYTSAMATEEYPES 82
Cdd:MTH00065   2 MYLGFLGMLGLVVGLVAVASNPSPYFAALGLVLGAVCGCLVLVELGVSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPEA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15079201   83 WvGNMVAFSMLLFTLFVELVWYFMSGEVEVDTAVELFDTVGVYCVGQDSSGVSLLYGCGGWILVLLGWVLFITIYIVLEI 162
Cdd:MTH00065  82 W-GSWSVLVYVLFYLLLLIVGYILFGCNFSLEFLFTNYDTEFSVVGYDWGGVGLMYSSGGWFLMISGWVLLLTLFVVLEV 160


                 ...
gi 15079201  163 VRG 165
Cdd:MTH00065 161 TRG 163
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 3-166 7.82e-37

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 124.87  E-value: 7.82e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15079201    3 MMVVFLFSVLFIFGFVAFASKPSPIYGGLSLVVSGGLGSAIVVSLENTFLGLVVFLVYLGGMLVVFGYTSAMATEEYPES 82
Cdd:MTH00138   2 TYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPES 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15079201   83 WVGNMVAFSMLLFTLFVELV-WYFMSGEVEVDTAVelFDTVGVYCVGQ-DSSGVSLLYGCGGWILVLLGWVLFITIYIVL 160
Cdd:MTH00138  82 WGSWSVLGYVVGYLVGVVLAaGLFWGGWYEGSWVV--VDELKEFSVLRgDVGGVALMYSSGGGMLVICAWVLLLTLFVVL 159


                 ....*.
gi 15079201  161 EIVRGR 166
Cdd:MTH00138 160 ELTRGL 165
ND6 MTH00115
NADH dehydrogenase subunit 6; Provisional
 3-165 2.61e-29

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214424  Cd Length: 174  Bit Score: 105.60  E-value: 2.61e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15079201    3 MMVVFLFSVLFIFGFVAFASKPSPIYGGLSLVVSGGLGSAIVVSLENTFLGLVVFLVYLGGMLVVFGYTSAMATEEYPES 82
Cdd:MTH00115   2 MYFVFLLGVCFVLGVVGVASNPSPYYGVVSLVLASVFGCGVLVSLGGSFVSLVLFLVYLGGMLVVFAYSVSLAADPYPEA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15079201   83 WVGNMVAFSMLLFTLFVELVWYFMSGEVEV-DTAVELFDTVGVYCVGQDSSGVSLLYGCGGWILVLLGWVLFITIYIVLE 161
Cdd:MTH00115  82 WGDWGVVGYVVGFVLVVVVVGVVVGGLWGMeGVGVVTVDSGGLFVVRLDFSGVSLFYSSGGGGLLVCGWGLLLTLFVVLE 161


                 ....
gi 15079201  162 IVRG 165
Cdd:MTH00115 162 LVRG 165
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 3-166 2.93e-18

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 76.95  E-value: 2.93e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15079201    3 MMVVFLFSVLFIFGFVAFASKPSPIYGGLSLVVSGGLGSAIVVSLENTFLGLVVFLVYLGGMLVVFGYTSAMATEEYPES 82
Cdd:MTH00214   2 LYFVFLLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALAADPYPES 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15079201   83 WVGNMVAFSMLLFTLFVELVWYFMSGEVEVDTAVelfdtVGVYCVGQDSSGVSLLYGCGGWILVLLGWVLFITIYIVLEI 162
Cdd:MTH00214  82 WGGWSVLLFFLFYLLGLGFVGFYFYGGWEMLSWM-----GVDEANNLDLSGVSDLYSRGFFLLLLGGVVLFLVLFVVLEL 156


                 ....
gi 15079201  163 VRGR 166
Cdd:MTH00214 157 VRGL 160
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 4-167 9.50e-13

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 62.23  E-value: 9.50e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15079201    4 MVVFLFSVLFIFGFVAFASKPSPIYGGLSLVVSGGLGSAIVVSLENTFLGLVVFLVYLGGMLVVFGYTSAMATEEYPesw 83
Cdd:MTH00045   1 MVFYLFLILMLFGSTLVFYSLSPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVYSSALSAERYP--- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15079201   84 vgNMVAFSMLLFTLFVELVWYFMSGEVEVDTAVELFDTVGvycvGQDSSGVSLLYGCGGWILVLLGWVLFITIYIVLEIV 163
Cdd:MTH00045  78 --SVSNLGEVLVLSLLLSLWVFISFDNFLELSNNNWSLVS----LSDLVGSSELYNSGGLYLLLGGFILLVALVVALVIS 151


                 ....
gi 15079201  164 RGRD 167
Cdd:MTH00045 152 FGHE 155
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
18-162 6.46e-10

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 54.43  E-value: 6.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15079201    18 VAFASKPSPIYGGLSLVVSGGLGSAIVVSLENTFLGLVVFLVYLGGMLVVFGYTSAMATEEYPESWVGN--MVAFSMLLF 95
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSglPLAALLLGL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15079201    96 TLFVELVWYFMSGEVEVDTAVELFDTVGVYCVGQdssgvsLLYGCGGWILVLLGWVLFITIYIVLEI 162
Cdd:pfam00499  81 LLLALLLLVLLSASLTPAAAAAAPDVGNIEAIGE------LLFTDYLLPFELASVLLLVALVGAIVL 141
ND6 MTH00212
NADH dehydrogenase subunit 6; Provisional
 4-162 2.22e-05

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214460  Cd Length: 160  Bit Score: 42.30  E-value: 2.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15079201    4 MVVFLFSVLFIFGFVAFASKPSPIYGGLSLVVSGGLGSAIVVSLENTFLGLVVFLVYLGGMLVVFGYTSAMATEEYpesw 83
Cdd:MTH00212   1 MLLSLLLSLLLLLMLLFPLSAHPLTLGVSLLLSSLLSCLIITMESNSWYGYILFLIYIGGLLVLFGYMVALSPNEH---- 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15079201   84 vGNMVAFSMLLFTLFVELVWYFMSgevevdTAVELFDTVGVYCVGQDSSGVSLLYGCGGWILVLLGWVLFITIYIVLEI 162
Cdd:MTH00212  77 -LFFKKYFKGFGMILISLNLYLLL------MTLGSSNFSPMLNLKLELNVSKILSNNNIPILLFLGLILLIALLMVVKI 148
ND6 MTH00152
NADH dehydrogenase subunit 6; Provisional
 3-155 3.75e-03

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214437  Cd Length: 163  Bit Score: 36.02  E-value: 3.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15079201    3 MMVVFLFSVLFIFGFVAFASKpSPIYGGLSLVVSGGLGSAIVVSLENTFLGLVVFLVYLGGMLVVFGYTSAMATEEYPES 82
Cdd:MTH00152   1 MSLMILLSVCFSLFLLLPLSK-QPLSLGLVLLLLSLFVCVEIGLTLSSWYGYLLFLVYVGGLLVMFAYVVSLSPNPLFGS 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15079201   83 WVGNMVAFSMLLFTLFVELVWYFMSGEVEVDTAVELFDTVGVYcvgqdSSGVSLLYGCGGWILVLLGWVLFIT 155
Cdd:MTH00152  80 NFKFVFFSLTLFGFLGLFFFFLYLYSSGGLSLSSLFDGSSGSL-----SFGGGLYSSSGWSIFVFLAVLLLIV 147
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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