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Conserved domains on  [gi|1503996|dbj|BAA13197|]
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KIAA0206, partial [Homo sapiens]

Protein Classification

PMP-22/EMP/MP20 family protein( domain architecture ID 229584)

PMP-22/EMP/MP20 family tetraspan membrane protein similar to human claudin-9 (hCLDN-9) which is highly expressed in the inner ear, essential for hearing and a high-affinity receptor of CpE

Gene Ontology:  GO:0016020
PubMed:  19706201

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
L_HMGIC_fpl super family cl48081
Lipoma HMGIC fusion partner-like protein; This is a group of proteins expressed from a series ...
 15-169 4.39e-53

Lipoma HMGIC fusion partner-like protein; This is a group of proteins expressed from a series of genes referred to as Lipoma HMGIC fusion partner-like. The proteins carry four highly conserved transmembrane domains in this entry. In certain instances, eg in LHFPL5, mutations cause deafness in humans and hypospadias, and LHFPL1 is transcribed in six liver tumour cell lines.


The actual alignment was detected with superfamily member pfam10242:

Pssm-ID: 463019  Cd Length: 176  Bit Score: 167.51  E-value: 4.39e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1503996     15 GGGSPEPYHPTLGIYARCIRNPgvqhfQRDTLCGPYAESFGEIASGFWQATAIFLAVGIFILCMVALVSVFTMCvqsiMK 94
Cdd:pfam10242  27 GGSVSSPKAGSFGLYSRCVGPD-----QMVLTCGRYALDFLAIPSSAWQAAMFFVGLGIFLLLSIACLSLFTFC----RS 97

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1503996     95 KSIFNVCGLLQGIAGLFLILGLILYPAGWGCQKAIDYCGHYASAYKPGDCSLGWAFYTAI----GGTVLTFICAVFSAQ 169
Cdd:pfam10242  98 KSVFNICGWLQLIAGLCLMLGCMLYPDGWDSPEVRRYCGPEAGKFQLGLCSIGWAYYLAIigiaDALLLTFLAFVLSLR 176
 
Name Accession Description Interval E-value
L_HMGIC_fpl pfam10242
Lipoma HMGIC fusion partner-like protein; This is a group of proteins expressed from a series ...
 15-169 4.39e-53

Lipoma HMGIC fusion partner-like protein; This is a group of proteins expressed from a series of genes referred to as Lipoma HMGIC fusion partner-like. The proteins carry four highly conserved transmembrane domains in this entry. In certain instances, eg in LHFPL5, mutations cause deafness in humans and hypospadias, and LHFPL1 is transcribed in six liver tumour cell lines.


Pssm-ID: 463019  Cd Length: 176  Bit Score: 167.51  E-value: 4.39e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1503996     15 GGGSPEPYHPTLGIYARCIRNPgvqhfQRDTLCGPYAESFGEIASGFWQATAIFLAVGIFILCMVALVSVFTMCvqsiMK 94
Cdd:pfam10242  27 GGSVSSPKAGSFGLYSRCVGPD-----QMVLTCGRYALDFLAIPSSAWQAAMFFVGLGIFLLLSIACLSLFTFC----RS 97

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1503996     95 KSIFNVCGLLQGIAGLFLILGLILYPAGWGCQKAIDYCGHYASAYKPGDCSLGWAFYTAI----GGTVLTFICAVFSAQ 169
Cdd:pfam10242  98 KSVFNICGWLQLIAGLCLMLGCMLYPDGWDSPEVRRYCGPEAGKFQLGLCSIGWAYYLAIigiaDALLLTFLAFVLSLR 176
 
Name Accession Description Interval E-value
L_HMGIC_fpl pfam10242
Lipoma HMGIC fusion partner-like protein; This is a group of proteins expressed from a series ...
 15-169 4.39e-53

Lipoma HMGIC fusion partner-like protein; This is a group of proteins expressed from a series of genes referred to as Lipoma HMGIC fusion partner-like. The proteins carry four highly conserved transmembrane domains in this entry. In certain instances, eg in LHFPL5, mutations cause deafness in humans and hypospadias, and LHFPL1 is transcribed in six liver tumour cell lines.


Pssm-ID: 463019  Cd Length: 176  Bit Score: 167.51  E-value: 4.39e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1503996     15 GGGSPEPYHPTLGIYARCIRNPgvqhfQRDTLCGPYAESFGEIASGFWQATAIFLAVGIFILCMVALVSVFTMCvqsiMK 94
Cdd:pfam10242  27 GGSVSSPKAGSFGLYSRCVGPD-----QMVLTCGRYALDFLAIPSSAWQAAMFFVGLGIFLLLSIACLSLFTFC----RS 97

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1503996     95 KSIFNVCGLLQGIAGLFLILGLILYPAGWGCQKAIDYCGHYASAYKPGDCSLGWAFYTAI----GGTVLTFICAVFSAQ 169
Cdd:pfam10242  98 KSVFNICGWLQLIAGLCLMLGCMLYPDGWDSPEVRRYCGPEAGKFQLGLCSIGWAYYLAIigiaDALLLTFLAFVLSLR 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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