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Conserved domains on  [gi|1499078941|gb|RMN58915|]
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Alginate biosynthesis regulatory protein AlgR [Pseudomonas syringae pv. apii]

Protein Classification

LytR/AlgR family response regulator transcription factor( domain architecture ID 11461715)

LytR/AlgR family response regulator transcription factor with a signal receiver (REC) and a DNA-binding domain may be part of a two-component regulatory system

CATH:  3.40.50.2300|2.40.50.1020
Gene Ontology:  GO:0000160|GO:0000156|GO:0003677
PubMed:  11557134|27013338|18462668|31100988|20226724|16740923|12034833
SCOP:  4003632|4004734

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 1-244 2.92e-87

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


:

Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 258.59  E-value: 2.92e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEPLARERLSRMVNEIEGYRVLeDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVF 80
Cdd:COG3279     2 MKILIVDDEPLARERLERLLEKYPDLEVV-GEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRELDPPPPIIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941  81 CTAHDEFALEAFQVSAVGYLVKPVRAEHLIEALKKAERPNRvqlaamTRPAAESGSGPRTHISARTRKGIELIPLDQVIY 160
Cdd:COG3279    81 TTAYDEYALEAFEVNAVDYLLKPIDEERLAKALEKAKERLE------AKAAAEASPEEKDRIFVKSGGKLVKIPLDDILY 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941 161 FIADHKYVTLRHEGGEVLLDEPLKALEDEFG-DRFVRIHRNALVARKRIESMKRTPVGHFELflrgLNGDALIVSRRHVA 239
Cdd:COG3279   155 IEAEGNYVKIHTKDKKYLVRKTLKELEEKLPpKQFFRVHRSYIVNLDKIKEIEKNFNGEVVL----KNGEEIPVSRRYKK 230


                  ....*
gi 1499078941 240 GVRKM 244
Cdd:COG3279   231 EFKEW 235
 
Name Accession Description Interval E-value
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 1-244 2.92e-87

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 258.59  E-value: 2.92e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEPLARERLSRMVNEIEGYRVLeDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVF 80
Cdd:COG3279     2 MKILIVDDEPLARERLERLLEKYPDLEVV-GEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRELDPPPPIIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941  81 CTAHDEFALEAFQVSAVGYLVKPVRAEHLIEALKKAERPNRvqlaamTRPAAESGSGPRTHISARTRKGIELIPLDQVIY 160
Cdd:COG3279    81 TTAYDEYALEAFEVNAVDYLLKPIDEERLAKALEKAKERLE------AKAAAEASPEEKDRIFVKSGGKLVKIPLDDILY 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941 161 FIADHKYVTLRHEGGEVLLDEPLKALEDEFG-DRFVRIHRNALVARKRIESMKRTPVGHFELflrgLNGDALIVSRRHVA 239
Cdd:COG3279   155 IEAEGNYVKIHTKDKKYLVRKTLKELEEKLPpKQFFRVHRSYIVNLDKIKEIEKNFNGEVVL----KNGEEIPVSRRYKK 230


                  ....*
gi 1499078941 240 GVRKM 244
Cdd:COG3279   231 EFKEW 235
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 3-121 5.74e-53

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 167.33  E-value: 5.74e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVNEIEGYRVLEdSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFCT 82
Cdd:cd17532     1 ALIVDDEPLAREELRYLLEEHPDIEIVG-EAENGEEALEAIEELKPDVVFLDIQMPGLDGLELAKKLSKLAKPPLIVFVT 79

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1499078941  83 AHDEFALEAFQVSAVGYLVKPVRAEHLIEALKKAERPNR 121
Cdd:cd17532    80 AYDEYAVEAFELNAVDYLLKPFSEERLAEALAKLRKRLS 118
PRK11697 PRK11697
two-component system response regulator BtsR;
1-244 4.32e-43

two-component system response regulator BtsR;


Pssm-ID: 236956 [Multi-domain]  Cd Length: 238  Bit Score: 145.76  E-value: 4.32e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEPLARERLSRMVNEIEGYRVLeDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLcEREAPPAVVF 80
Cdd:PRK11697    2 IKVLIVDDEPLAREELRELLQEEGDIEIV-GECSNAIEAIGAIHRLKPDVVFLDIQMPRISGLELVGML-DPEHMPYIVF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941  81 CTAHDEFALEAFQVSAVGYLVKPVRAEHLIEALKKAERPNRVQLAAMTRPAAesgsgPRTHISARTRKGIELIPLDQVIY 160
Cdd:PRK11697   80 VTAFDEYAIKAFEEHAFDYLLKPIDPARLAKTLARLRQERSPQDVLLPEAQP-----PLKHIPCTGHNRIKLLPLEEVEF 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941 161 FIADHKYVTLRHEGGEVLLDEPLKALEDEFGdrFVRIHRNALVARKRIESMKRTPVGHFELFLRglNGDALIVSRRHVAG 240
Cdd:PRK11697  155 VSSRLSGVHVVSAEGKGFTELTLKTLEEKTP--LLRCHRQYLVNPAAIQEIRLLDNGQAEIITR--SGHTVPVSRRYLKS 230


                  ....
gi 1499078941 241 VRKM 244
Cdd:PRK11697  231 LKEA 234
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 3-114 1.02e-34

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 120.33  E-value: 1.02e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVnEIEGYRVleDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFCT 82
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLL-EKEGYVV--AEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILT 77

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1499078941  83 AHDE--FALEAFQVSAVGYLVKPVRAEHLIEALK 114
Cdd:pfam00072  78 AHGDedDAVEALEAGADDFLSKPFDPDELLAAIR 111
LytTR smart00850
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 148-244 9.02e-24

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 197918 [Multi-domain]  Cd Length: 96  Bit Score: 91.48  E-value: 9.02e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941  148 KGIELIPLDQVIYFIADHKYVTLRHEGGEVLLDEPLKALEDE-FGDRFVRIHRNALVARKRIESMKRTPVGHFELFLRgl 226
Cdd:smart00850   1 GRIVLIPLDDILYIEAEGNYVTVHTKDGTYLVRGTLKELEERlDPDNFFRIHRSYIVNLDHIKEIEPWFNGTYLLILK-- 78

                           90
                   ....*....|....*...
gi 1499078941  227 NGDALIVSRRHVAGVRKM 244
Cdd:smart00850  79 NGEEVPVSRRYLKELKER 96
spore_0_A TIGR02875
sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a ...
 3-109 4.63e-11

sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a transcription factor critical for the initiation of sporulation. It contains a response regulator receiver domain (pfam00072). In Bacillus subtilis, it works together with response regulator Spo0F and the phosphotransferase Spo0B, both of which are missing from at least some sporulating species and thus not part of the endospore forming bacteria minimal gene set. Spo0A, however, is universal among endospore-forming species. [Cellular processes, Sporulation and germination]


Pssm-ID: 131922 [Multi-domain]  Cd Length: 262  Bit Score: 61.35  E-value: 4.63e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVNEIEGYRVLeDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKL--CEREAPPAVVF 80
Cdd:TIGR02875   5 IVIADDNKEFCNLLKEYLAAQPDMEVV-GVAHNGVDALELIKEQQPDVVVLDIIMPHLDGIGVLEKLneIELSARPRVIM 83

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1499078941  81 CTA--HDEFALEAFQVSAVGYLVKPVRAEHL 109
Cdd:TIGR02875  84 LSAfgQEKITQRAVALGADYYVLKPFDLEIL 114
 
Name Accession Description Interval E-value
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 1-244 2.92e-87

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 258.59  E-value: 2.92e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEPLARERLSRMVNEIEGYRVLeDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVF 80
Cdd:COG3279     2 MKILIVDDEPLARERLERLLEKYPDLEVV-GEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRELDPPPPIIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941  81 CTAHDEFALEAFQVSAVGYLVKPVRAEHLIEALKKAERPNRvqlaamTRPAAESGSGPRTHISARTRKGIELIPLDQVIY 160
Cdd:COG3279    81 TTAYDEYALEAFEVNAVDYLLKPIDEERLAKALEKAKERLE------AKAAAEASPEEKDRIFVKSGGKLVKIPLDDILY 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941 161 FIADHKYVTLRHEGGEVLLDEPLKALEDEFG-DRFVRIHRNALVARKRIESMKRTPVGHFELflrgLNGDALIVSRRHVA 239
Cdd:COG3279   155 IEAEGNYVKIHTKDKKYLVRKTLKELEEKLPpKQFFRVHRSYIVNLDKIKEIEKNFNGEVVL----KNGEEIPVSRRYKK 230


                  ....*
gi 1499078941 240 GVRKM 244
Cdd:COG3279   231 EFKEW 235
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 3-121 5.74e-53

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 167.33  E-value: 5.74e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVNEIEGYRVLEdSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFCT 82
Cdd:cd17532     1 ALIVDDEPLAREELRYLLEEHPDIEIVG-EAENGEEALEAIEELKPDVVFLDIQMPGLDGLELAKKLSKLAKPPLIVFVT 79

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1499078941  83 AHDEFALEAFQVSAVGYLVKPVRAEHLIEALKKAERPNR 121
Cdd:cd17532    80 AYDEYAVEAFELNAVDYLLKPFSEERLAEALAKLRKRLS 118
PRK11697 PRK11697
two-component system response regulator BtsR;
1-244 4.32e-43

two-component system response regulator BtsR;


Pssm-ID: 236956 [Multi-domain]  Cd Length: 238  Bit Score: 145.76  E-value: 4.32e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEPLARERLSRMVNEIEGYRVLeDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLcEREAPPAVVF 80
Cdd:PRK11697    2 IKVLIVDDEPLAREELRELLQEEGDIEIV-GECSNAIEAIGAIHRLKPDVVFLDIQMPRISGLELVGML-DPEHMPYIVF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941  81 CTAHDEFALEAFQVSAVGYLVKPVRAEHLIEALKKAERPNRVQLAAMTRPAAesgsgPRTHISARTRKGIELIPLDQVIY 160
Cdd:PRK11697   80 VTAFDEYAIKAFEEHAFDYLLKPIDPARLAKTLARLRQERSPQDVLLPEAQP-----PLKHIPCTGHNRIKLLPLEEVEF 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941 161 FIADHKYVTLRHEGGEVLLDEPLKALEDEFGdrFVRIHRNALVARKRIESMKRTPVGHFELFLRglNGDALIVSRRHVAG 240
Cdd:PRK11697  155 VSSRLSGVHVVSAEGKGFTELTLKTLEEKTP--LLRCHRQYLVNPAAIQEIRLLDNGQAEIITR--SGHTVPVSRRYLKS 230


                  ....
gi 1499078941 241 VRKM 244
Cdd:PRK11697  231 LKEA 234
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 3-116 3.76e-40

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 134.39  E-value: 3.76e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVNEIE-GYRVLeDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFC 81
Cdd:cd17536     1 VLIVDDEPLIREGLKKLIDWEElGFEVV-GEAENGEEALELIEEHKPDIVITDIRMPGMDGLELIEKIRELYPDIKIIIL 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1499078941  82 TAHDEF--ALEAFQVSAVGYLVKPVRAEHLIEALKKA 116
Cdd:cd17536    80 SGYDDFeyAQKAIRLGVVDYLLKPVDEEELEEALEKA 116
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 2-103 3.16e-36

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 123.73  E-value: 3.16e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   2 NVLIVDDEPLARERLSRMVNEIEGYRVLeDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFC 81
Cdd:COG4753     1 KVLIVDDEPLIREGLKRILEWEAGFEVV-GEAENGEEALELLEEHKPDLVITDINMPGMDGLELLEAIRELDPDTKIIIL 79

                          90       100
                  ....*....|....*....|....
gi 1499078941  82 TAHDEF--ALEAFQVSAVGYLVKP 103
Cdd:COG4753    80 SGYSDFeyAQEAIKLGADDYLLKP 103
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 3-114 1.02e-34

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 120.33  E-value: 1.02e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVnEIEGYRVleDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFCT 82
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLL-EKEGYVV--AEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILT 77

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1499078941  83 AHDE--FALEAFQVSAVGYLVKPVRAEHLIEALK 114
Cdd:pfam00072  78 AHGDedDAVEALEAGADDFLSKPFDPDELLAAIR 111
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 3-116 1.15e-31

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 112.61  E-value: 1.15e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVNEIEGYRVLEDsASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFCT 82
Cdd:cd17535     1 VLIVDDHPLVREGLRRLLESEPDIEVVGE-AADGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRRYPDLKVIVLT 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1499078941  83 AHDE--FALEAFQVSAVGYLVKPVRAEHLIEALKKA 116
Cdd:cd17535    80 AHDDpeYVLRALKAGAAGYLLKDSSPEELIEAIRAV 115
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 1-118 2.18e-31

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 112.76  E-value: 2.18e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEPLARERLSRMVNEIEGYRVLEdSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVF 80
Cdd:COG4565     4 IRVLIVEDDPMVAELLRRYLERLPGFEVVG-VASSGEEALALLAEHRPDLILLDIYLPDGDGLELLRELRARGPDVDVIV 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1499078941  81 CTAHDEFAL--EAFQVSAVGYLVKPVRAEHLIEALKKAER 118
Cdd:COG4565    83 ITAARDPETvrEALRAGVVDYLIKPFTFERLREALERYLE 122
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 1-116 8.08e-31

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 110.71  E-value: 8.08e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEPLARERLSRMVNEIeGYRVLEdsASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPA--V 78
Cdd:COG0784     6 KRILVVDDNPDNRELLRRLLERL-GYEVTT--AEDGAEALELLRAGPPDLILLDINMPGMDGLELLRRIRALPRLPDipI 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1499078941  79 VFCTAH--DEFALEAFQVSAVGYLVKPVRAEHLIEALKKA 116
Cdd:COG0784    83 IALTAYadEEDRERALEAGADDYLTKPVDPEELLEALRRL 122
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 1-123 1.55e-29

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 114.29  E-value: 1.55e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEPLARERLSRMVNEiEGYRVLEdsASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVF 80
Cdd:COG2204     3 ARILVVDDDPDIRRLLKELLER-AGYEVET--AASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELRALDPDLPVIL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1499078941  81 CTAHD--EFALEAFQVSAVGYLVKPVRAEHLIEALKKAERPNRVQ 123
Cdd:COG2204    80 LTGYGdvETAVEAIKAGAFDYLTKPFDLEELLAAVERALERRRLR 124
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 1-113 1.56e-29

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 109.23  E-value: 1.56e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEPLARERLSRMVNEiEGYRVLEdsASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCERE--APPAV 78
Cdd:COG3706     2 ARILVVDDDPTNRKLLRRLLEA-AGYEVVE--AADGEEALELLQEHRPDLILLDLEMPDMDGLELCRRLRADPrtADIPI 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1499078941  79 VFCTAHD--EFALEAFQVSAVGYLVKPVRAEHLIEAL 113
Cdd:COG3706    79 IFLTALDdeEDRARALEAGADDYLTKPFDPEELLARV 115
PRK14084 PRK14084
DNA-binding response regulator;
1-210 3.63e-29

DNA-binding response regulator;


Pssm-ID: 184495 [Multi-domain]  Cd Length: 246  Bit Score: 109.84  E-value: 3.63e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEPLARERLSRMVNEIEGYRVLeDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVF 80
Cdd:PRK14084    1 MKALIVDDEPLARNELTYLLNEIGGFEEI-NEAENVKETLEALLINQYDIIFLDINLMDESGIELAAKIQKMKEPPAIIF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941  81 CTAHDEFALEAFQVSAVGYLVKPVRAEHLIEALKKAERP--NRVQLAAMTRPAAESGSGPRTHISARTRkgIELIPLDQV 158
Cdd:PRK14084   80 ATAHDQFAVKAFELNATDYILKPFEQKRIEQAVNKVRATkaKDDNNASAIANDMSANFDQSLPIEIDDK--IHMLNQQDI 157

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1499078941 159 IYFIADHKYVTLRHEGGEVLLDEPLKALEDEFGDR-FVRIHRNALVARKRIES 210
Cdd:PRK14084  158 IAIGVHNGITTIHTTNHKYETTEPLNRYEKRLNPTyFIRIHRSYIINKKHIKE 210
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 4-103 7.67e-29

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 104.62  E-value: 7.67e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   4 LIVDDEPLARERLSRMVnEIEGYRVleDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFCTA 83
Cdd:cd00156     1 LIVDDDPAIRELLKSLL-EREGYEV--DTAADGEEALELLREERPDLVLLDLMMPGMDGLELLRKLRELPPDIPVIVLTA 77

                          90       100
                  ....*....|....*....|..
gi 1499078941  84 HDEF--ALEAFQVSAVGYLVKP 103
Cdd:cd00156    78 KADEedAVRALELGADDYLVKP 99
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 1-116 3.21e-28

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 103.64  E-value: 3.21e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEPLARERLSRMVnEIEGYRVLEdSASNGEEALALIEKHKPDVVLLDIRMPG-IDGLQVAAKLCEREAPPaVV 79
Cdd:cd17534     1 KKILIVEDEAIIALDLKEIL-ESLGYEVVG-IADSGEEAIELAEENKPDLILMDINLKGdMDGIEAAREIREKFDIP-VI 77

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1499078941  80 FCTAH-DEFALE-AFQVSAVGYLVKPVRAEHLIEALKKA 116
Cdd:cd17534    78 FLTAYsDEETLErAKETNPYGYLVKPFNERELKAAIELA 116
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 3-209 1.54e-27

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 104.65  E-value: 1.54e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVNEiEGYRVleDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFCT 82
Cdd:COG0745     4 ILVVEDDPDIRELLADALER-EGYEV--DTAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRARPSDIPIIMLT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941  83 AHDEFA--LEAFQVSAVGYLVKPVRAEHL---IEALKKAERPNRVQLAAMTRPAAEsgsgprthisaRTRKGIELIPLDQ 157
Cdd:COG0745    81 ARDDEEdrVRGLEAGADDYLTKPFDPEELlarIRALLRRRAAEVLRVGDLLDLAAR-----------EVTRDGEPVELTP 149

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1499078941 158 VIYFIAdhkYVTLRHEGGEVLLDEPLKAL--EDEFGDRFVRIHRNALvaRKRIE 209
Cdd:COG0745   150 KEFRLL---ELLMRNPGRVVSREQLLEEVwgYDYGDDRTVDVHISRL--RKKLE 198
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 1-125 4.09e-27

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 104.09  E-value: 4.09e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEPLARERLSRMVnEIEGYRVLEdsASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPA--V 78
Cdd:COG3437     7 PTVLIVDDDPENLELLRQLL-RTLGYDVVT--AESGEEALELLLEAPPDLILLDVRMPGMDGFELLRLLRADPSTRDipV 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1499078941  79 VFCTAHD--EFALEAFQVSAVGYLVKPVRAEHLIEALKKAERPNRVQLA 125
Cdd:COG3437    84 IFLTALAdpEDRERALEAGADDYLTKPFDPEELLARVRNALELRRLQRE 132
LytTR pfam04397
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 148-246 1.02e-25

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 427920 [Multi-domain]  Cd Length: 98  Bit Score: 96.51  E-value: 1.02e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941 148 KGIELIPLDQVIYFIADHKYVTLRHEGGEVLLDEPLKALEDEF-GDRFVRIHRNALVARKRIESMKRTPVGHFELFLRgl 226
Cdd:pfam04397   1 DRIILVPIDDILYIEAEDKYVTIHTANGEYLTRGTLKELEEKLpPDGFFRCHRSYLVNLNKIKEIDPDFNGTYELTLK-- 78

                          90       100
                  ....*....|....*....|
gi 1499078941 227 NGDALIVSRRHVAGVRKMMQ 246
Cdd:pfam04397  79 NGEKIPVSRRYLKELKELLG 98
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
 1-102 4.96e-25

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 95.37  E-value: 4.96e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEPLARErLSRMVNEIEGYRVLedSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVF 80
Cdd:cd17554     1 KKILVVDDEENIRE-LYKEELEDEGYEVV--TAGNGEEALEKLESEDPDLVILDIKMPGMDGLETLRKIREKKPDLPVII 77

                          90       100
                  ....*....|....*....|..
gi 1499078941  81 CTAHDEFALEAFQVSAVGYLVK 102
Cdd:cd17554    78 CTAYSEYKSDFSSWAADAYVVK 99
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 1-116 5.61e-25

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 95.56  E-value: 5.61e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEPLARERLSRMVNEiEGYRVLEDsASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPaVVF 80
Cdd:cd19932     1 VRVLIAEDEALIRMDLREMLEE-AGYEVVGE-ASDGEEAVELAKKHKPDLVIMDVKMPRLDGIEAAKIITSENIAP-IVL 77

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1499078941  81 CTAHDEFAL--EAFQVSAVGYLVKPVRAEHLIEALKKA 116
Cdd:cd19932    78 LTAYSQQDLveRAKEAGAMAYLVKPFSESDLIPAIEMA 115
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 3-113 3.44e-24

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 92.92  E-value: 3.44e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVNEIeGYRVleDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCERE---APPAVV 79
Cdd:cd17546     1 VLVVDDNPVNRKVLKKLLEKL-GYEV--DVAENGQEALELLKEEPFDLVLMDLQMPVMDGLEATRRIRELEgggRRTPII 77

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1499078941  80 FCTAH--DEFALEAFQVSAVGYLVKPVRAEHLIEAL 113
Cdd:cd17546    78 ALTANalEEDREKCLEAGMDDYLSKPVKLDQLKEVL 113
LytTR smart00850
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 148-244 9.02e-24

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 197918 [Multi-domain]  Cd Length: 96  Bit Score: 91.48  E-value: 9.02e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941  148 KGIELIPLDQVIYFIADHKYVTLRHEGGEVLLDEPLKALEDE-FGDRFVRIHRNALVARKRIESMKRTPVGHFELFLRgl 226
Cdd:smart00850   1 GRIVLIPLDDILYIEAEGNYVTVHTKDGTYLVRGTLKELEERlDPDNFFRIHRSYIVNLDHIKEIEPWFNGTYLLILK-- 78

                           90
                   ....*....|....*...
gi 1499078941  227 NGDALIVSRRHVAGVRKM 244
Cdd:smart00850  79 NGEEVPVSRRYLKELKER 96
REC_DivK-like cd17548
phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus ...
 2-115 1.19e-23

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381100 [Multi-domain]  Cd Length: 115  Bit Score: 91.83  E-value: 1.19e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   2 NVLIVDDEPLARErLSRMVNEIEGYRVLEdsASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCE----REAPpa 77
Cdd:cd17548     1 KILIVEDNPLNMK-LARDLLESAGYEVLE--AADGEEALEIARKEKPDLILMDIQLPGMDGLEATRLLKEdpatRDIP-- 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1499078941  78 VVFCTAH-----DEFALEAfqvSAVGYLVKPVRAEHLIEALKK 115
Cdd:cd17548    76 VIALTAYamkgdREKILEA---GCDGYISKPIDTREFLETVAK 115
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
 1-114 1.54e-23

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 91.68  E-value: 1.54e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEPLARERLSRMVNEIEGYRVLeDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLcEREAPPAVVF 80
Cdd:cd17541     1 IRVLIVDDSAVMRKLLSRILESDPDIEVV-GTARDGEEALEKIKELKPDVITLDIEMPVMDGLEALRRI-MAERPTPVVM 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1499078941  81 CTAHD----EFALEAFQVSAVGYLVKPVR---------AEHLIEALK 114
Cdd:cd17541    79 VSSLTeegaEITLEALELGAVDFIAKPSGgisldleeiAEELIEKIK 125
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
 3-104 2.61e-23

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 90.63  E-value: 2.61e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVnEIEGYRVLEdsASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPA--VVF 80
Cdd:cd17538     2 ILVVDDEPANRELLEALL-SAEGYEVLT--ADSGQEALALAEEELPDLILLDVMMPGMDGFEVCRRLKEDPETRHipVIM 78

                          90       100
                  ....*....|....*....|....*.
gi 1499078941  81 CTAHDEFA--LEAFQVSAVGYLVKPV 104
Cdd:cd17538    79 ITALDDREdrIRGLEAGADDFLSKPI 104
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 3-132 5.17e-23

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 92.47  E-value: 5.17e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVnEIEGYRVleDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFCT 82
Cdd:COG4566     2 VYIVDDDEAVRDSLAFLL-ESAGLRV--ETFASAEAFLAALDPDRPGCLLLDVRMPGMSGLELQEELAARGSPLPVIFLT 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1499078941  83 AH-D-EFALEAFQVSAVGYLVKPVRAEHLIEALKKAERPNRVQLAAMTRPAA 132
Cdd:COG4566    79 GHgDvPMAVRAMKAGAVDFLEKPFDDQALLDAVRRALARDRARRAERARRAE 130
REC_PA4781-like cd19920
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar ...
 3-104 6.70e-23

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains; Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381147 [Multi-domain]  Cd Length: 103  Bit Score: 89.49  E-value: 6.70e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVNEiEGYRVLedSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVaaklCER-EAPPA---- 77
Cdd:cd19920     1 ILIVDDVPDNLRLLSELLRA-AGYRVL--VATDGQQALQRAQAEPPDLILLDVMMPGMDGFEV----CRRlKADPAtrhi 73

                          90       100       110
                  ....*....|....*....|....*....|
gi 1499078941  78 -VVFCTAHDEFA--LEAFQVSAVGYLVKPV 104
Cdd:cd19920    74 pVIFLTALTDTEdkVKGFELGAVDYITKPF 103
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 1-116 7.40e-23

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 89.64  E-value: 7.40e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEPLARERLSRMVNEiEGYRVLeDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVF 80
Cdd:cd17542     1 KKVLIVDDAAFMRMMLKDILTK-AGYEVV-GEAANGEEAVEKYKELKPDLVTMDITMPEMDGIEALKEIKKIDPNAKVIM 78

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1499078941  81 CTA--HDEFALEAFQVSAVGYLVKPVRAEHLIEALKKA 116
Cdd:cd17542    79 CSAmgQEEMVKEAIKAGAKDFIVKPFQPERVLEAVEKV 116
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
 3-125 1.35e-21

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 86.77  E-value: 1.35e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVnEIEGYRVLedSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFCT 82
Cdd:cd17549     1 VLLVDDDADVREALQQTL-ELAGFRVR--AFADAEEALAALSPDFPGVVISDIRMPGMDGLELLAQIRELDPDLPVILIT 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1499078941  83 AH-D-EFALEAFQVSAVGYLVKPVRAEHLIEALKKAERPNRVQLA 125
Cdd:cd17549    78 GHgDvPMAVEAMRAGAYDFLEKPFDPERLLDVVRRALEKRRLVLE 122
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
 3-116 1.49e-21

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 86.48  E-value: 1.49e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEP-LARerLSRMVNEIEGYRVleDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFC 81
Cdd:cd17572     1 VLLVEDSPsLAA--LYQEYLSDEGYKV--THVETGKEALAFLSDQPPDVVLLDLKLPDMSGMEILKWIQERSLPTSVIVI 76

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1499078941  82 TAHD--EFALEAFQVSAVGYLVKPVRAEHLIEALKKA 116
Cdd:cd17572    77 TAHGsvDIAVEAMRLGAYDFLEKPFDADRLRVTVRNA 113
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
 3-116 3.75e-21

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 85.40  E-value: 3.75e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVNEiEGYRVLedSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFCT 82
Cdd:cd19919     3 VWIVDDDSSIRWVLERALAG-AGLTVT--SFENAQEALAALASSQPDVLISDIRMPGMDGLALLAQIKQRHPDLPVIIMT 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1499078941  83 AHD--EFALEAFQVSAVGYLVKPVRAEHLIEALKKA 116
Cdd:cd19919    80 AHSdlDSAVSAYQGGAFEYLPKPFDIDEAVALVERA 115
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 4-103 4.12e-21

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 84.77  E-value: 4.12e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   4 LIVDDEPLARERLSRMVnEIEGYRVleDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFCTA 83
Cdd:cd17574     1 LVVEDDEEIAELLSDYL-EKEGYEV--DTAADGEEALELAREEQPDLIILDVMLPGMDGFEVCRRLREKGSDIPIIMLTA 77

                          90       100
                  ....*....|....*....|..
gi 1499078941  84 HDEFA--LEAFQVSAVGYLVKP 103
Cdd:cd17574    78 KDEEEdkVLGLELGADDYITKP 99
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 1-104 4.90e-21

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 85.19  E-value: 4.90e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEPLARERLSRMVNEIEGYRVleDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLceREAP----P 76
Cdd:cd17551     1 MRILIVDDNPTNLLLLEALLRSAGYLEV--VSFTDPREALAWCRENPPDLILLDYMMPGMDGLEFIRRL--RALPgledV 76

                          90       100       110
                  ....*....|....*....|....*....|
gi 1499078941  77 AVVFCTAHD--EFALEAFQVSAVGYLVKPV 104
Cdd:cd17551    77 PIVMITADTdrEVRLRALEAGATDFLTKPF 106
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
 3-113 1.21e-20

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 83.66  E-value: 1.21e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVnEIEGYRVLedSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREA---PPAVV 79
Cdd:cd17580     1 ILVVDDNEDAAEMLALLL-ELEGAEVT--TAHSGEEALEAAQRFRPDVILSDIGMPGMDGYELARRLRELPWlanTPAIA 77

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1499078941  80 ---FCTAHD-EFALEA-FQvsavGYLVKPVRAEHLIEAL 113
Cdd:cd17580    78 ltgYGQPEDrERALEAgFD----AHLVKPVDPDELIELI 112
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
 3-116 1.58e-20

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 83.70  E-value: 1.58e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSrMVNEIEGYRVleDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFCT 82
Cdd:cd17550     1 ILIVDDEEDIRESLS-GILEDEGYEV--DTAADGEEALKLIKERRPDLVLLDIWLPDMDGLELLKEIKEKYPDLPVIMIS 77

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1499078941  83 AHD--EFALEAFQVSAVGYLVKPVRAEHLIEALKKA 116
Cdd:cd17550    78 GHGtiETAVKATKLGAYDFIEKPLSLDRLLLTIERA 113
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
 3-116 3.84e-20

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 82.64  E-value: 3.84e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVNEIeGYRVleDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFCT 82
Cdd:cd17537     3 VYVVDDDEAVRDSLAFLLRSV-GLAV--KTFTSASAFLAAAPPDQPGCLVLDVRMPGMSGLELQDELLARGSNIPIIFIT 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1499078941  83 AHDE--FALEAFQVSAVGYLVKPVRAEHLIEALKKA 116
Cdd:cd17537    80 GHGDvpMAVEAMKAGAVDFLEKPFRDQVLLDAIEQA 115
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 2-131 4.13e-20

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 84.20  E-value: 4.13e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   2 NVLIVDDEPLARERLSRMVnEIEGYRVleDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFC 81
Cdd:COG4567     6 SLLLVDDDEAFARVLARAL-ERRGFEV--TTAASVEEALALLEQAPPDYAVLDLRLGDGSGLDLIEALRERDPDARIVVL 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1499078941  82 T--AHDEFALEAFQVSAVGYLVKPVRAEHLIEALKKAERPNRVQLAAMTRPA 131
Cdd:COG4567    83 TgyASIATAVEAIKLGADDYLAKPADADDLLAALERAEGDAPAPPENPMSLD 134
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 3-104 5.35e-20

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 82.25  E-value: 5.35e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSrMVNEIEGYRVLEdsASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCER--EAPPAVVF 80
Cdd:cd17555     3 ILVIDDDEVVRESIA-AYLEDSGFQVLQ--AADGRQGLELFRSEQPDLVLCDLRMPEMDGLEVLKQITKEspDTPVIVVS 79

                          90       100
                  ....*....|....*....|....
gi 1499078941  81 CTAHDEFALEAFQVSAVGYLVKPV 104
Cdd:cd17555    80 GAGVMSDAVEALRLGAWDYLTKPI 103
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 2-113 6.08e-20

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 82.29  E-value: 6.08e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   2 NVLIVDDEPLARERLSRMVNEIEGYRVLEdSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFC 81
Cdd:cd19925     2 NVLIVEDDPMVAEIHRAYVEQVPGFTVIG-TAGTGEEALKLLKERQPDLILLDIYLPDGNGLDLLRELRAAGHDVDVIVV 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1499078941  82 TAHDEFAL--EAFQVSAVGYLVKPVRAEHLIEAL 113
Cdd:cd19925    81 TAANDVETvrEALRLGVVDYLIKPFTFERLRQRL 114
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 1-113 7.08e-20

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 84.24  E-value: 7.08e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEPLARERLSRMVNEIeGYRVLeDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVF 80
Cdd:COG3707     4 LRVLVVDDEPLRRADLREGLREA-GYEVV-AEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEERPAPVILL 81

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1499078941  81 cTAHD--EFALEAFQVSAVGYLVKPVRAEHLIEAL 113
Cdd:COG3707    82 -TAYSdpELIERALEAGVSAYLVKPLDPEDLLPAL 115
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 3-139 8.81e-20

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 84.31  E-value: 8.81e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVNEIEGYRVLeDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFCT 82
Cdd:PRK10651    9 ILLIDDHPMLRTGVKQLISMAPDITVV-GEASNGEQGIELAESLDPDLILLDLNMPGMNGLETLDKLREKSLSGRIVVFS 87

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1499078941  83 A--HDEFALEAFQVSAVGYLVKPVRAEHLIEALKKAERPNRVQLAAMTRPAAESGSGPR 139
Cdd:PRK10651   88 VsnHEEDVVTALKRGADGYLLKDMEPEDLLKALQQAAAGEMVLSEALTPVLAASLRANR 146
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 1-73 3.04e-19

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 80.71  E-value: 3.04e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1499078941   1 MNVLIVDDEPLARERLSRMVNEIEGYRVLeDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAK-LCERE 73
Cdd:COG2197     2 IRVLIVDDHPLVREGLRALLEAEPDIEVV-GEAADGEEALELLEELRPDVVLLDIRMPGMDGLEALRRlLTPRE 74
PRK00742 PRK00742
chemotaxis-specific protein-glutamate methyltransferase CheB;
3-148 9.65e-19

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 234828 [Multi-domain]  Cd Length: 354  Bit Score: 83.66  E-value: 9.65e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVNEIEGYRVLeDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQvAAKLCEREAPPAVVFCT 82
Cdd:PRK00742    6 VLVVDDSAFMRRLISEILNSDPDIEVV-GTAPDGLEAREKIKKLNPDVITLDVEMPVMDGLD-ALEKIMRLRPTPVVMVS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941  83 A--HD--EFALEAFQVSAVGYLVKPVRAEHL------------IEALKKAERPNRVQLAAMTRPAAESGSGPRTHISART 146
Cdd:PRK00742   84 SltERgaEITLRALELGAVDFVTKPFLGISLgmdeykeelaekVRAAARARVRALPPRAAAAARAAAAAPAALAAAPLLS 163


                  ..
gi 1499078941 147 RK 148
Cdd:PRK00742  164 SK 165
REC_CheC-like cd17593
phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC ...
 1-115 1.92e-18

phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC domain; This subfamily is composed of uncharacterized proteins containing an N-terminal REC domain and a C-terminal CheC domain that may function as the output/effector domain of a response regulator. CheC is a CheY-P phosphatase, affecting the level of phosphorylated CheY which controls the sense of flagella rotation and determine swimming behavior of chemotactic bacteria. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381124 [Multi-domain]  Cd Length: 117  Bit Score: 78.35  E-value: 1.92e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEPLARERLSRMVNEIEGYRVLEdsASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVF 80
Cdd:cd17593     1 MKVLICDDSSMARKQLARALPADWDVEITF--AENGEEALEILREGRIDVLFLDLTMPVMDGYEVLEALPVEQLETKVIV 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1499078941  81 CTA--HDEFALEAFQVSAVGYLVKPVRAEHLIEALKK 115
Cdd:cd17593    79 VSGdvQPEAKERVLELGALAFLKKPFDPEKLAQLLEE 115
Spo0A COG5801
Stage 0 sporulation initiation regulator Spo0A (response regulator, REC-HTH domains) [Cell ...
 1-111 3.67e-18

Stage 0 sporulation initiation regulator Spo0A (response regulator, REC-HTH domains) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444503 [Multi-domain]  Cd Length: 264  Bit Score: 81.00  E-value: 3.67e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEPLARERLSRMVNEIEGYRVLeDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKL--CEREAPPAV 78
Cdd:COG5801     5 IKVLIADDNREFCELLEEYLSSQPDMEVV-GVAYNGLEALELIEEKKPDVVILDIIMPHLDGLGVLEKLreMNLEKRPKV 83

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1499078941  79 VFCTA--HDEFALEAFQVSAVGYLVKPVRAEHLIE 111
Cdd:COG5801    84 IMLTAfgQEDITQRAVELGADYYILKPFDLDVLAE 118
REC_HupR-like cd17569
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar ...
 2-116 3.82e-18

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar domains; This family is composed of mostly uncharacterized response regulators with similarity to the REC domains of response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It contains an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. Members of this family contain a REC domain and various output domains including the cyclase homology domain (CHD) and the c-di-GMP phosphodiesterase domains, HD-GYP and EAL. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381113 [Multi-domain]  Cd Length: 118  Bit Score: 77.44  E-value: 3.82e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   2 NVLIVDDEPLARERLSRMVNEiEGYRVLedSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEReAPPAV-VF 80
Cdd:cd17569     2 TILLVDDEPNILKALKRLLRR-EGYEVL--TATSGEEALEILKQEPVDVVISDQRMPGMDGAELLKRVRER-YPDTVrIL 77

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1499078941  81 CTAHDEF--ALEAFQVSAV-GYLVKPVRAEHLIEALKKA 116
Cdd:cd17569    78 LTGYADLdaAIEAINEGEIyRFLTKPWDDEELKETIRQA 116
PRK12555 PRK12555
chemotaxis-specific protein-glutamate methyltransferase CheB;
1-139 6.00e-18

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 237135 [Multi-domain]  Cd Length: 337  Bit Score: 81.47  E-value: 6.00e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEPLARERLSRMVNEIEGYRVLEdSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQvAAKLCEREAPPAVVF 80
Cdd:PRK12555    1 MRIGIVNDSPLAVEALRRALARDPDHEVVW-VATDGAQAVERCAAQPPDVILMDLEMPRMDGVE-ATRRIMAERPCPILI 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1499078941  81 CTA----HDEFALEAFQVSAVGYLVKPVR---------AEHLIEALKKA----ERPNRVQLAAMTRPAAESGSGPR 139
Cdd:PRK12555   79 VTSlterNASRVFEAMGAGALDAVDTPTLgigagleeyAAELLAKIDQIgrllGRRLAPAAAPAAASAAPFRTTPR 154
REC_DesR-like cd19930
phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of ...
 3-115 1.52e-17

phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of Bacillus subtilis DesR, Streptococcus pneumoniae response regulator spr1814, and similar proteins, all containing an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. DesR is a response regulator that, together with its cognate sensor kinase DesK, comprises a two-component regulatory system that controls membrane fluidity. Phosphorylation of the REC domain of DesR is allosterically coupled to two distinct exposed surfaces of the protein, controlling noncanonical dimerization/tetramerization, cooperative activation, and DesK binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381157 [Multi-domain]  Cd Length: 117  Bit Score: 75.77  E-value: 1.52e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVNEIEGYRVLEDsASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFCT 82
Cdd:cd19930     1 VLIAEDQEMVRGALAALLELEDDLEVVAQ-ASNGQEALRLVLKHSPDVAILDIEMPGRTGLEVAAELREELPDTKVLIVT 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1499078941  83 -----AHDEFALEAfqvSAVGYLVKPVRAEHLIEALKK 115
Cdd:cd19930    80 tfgrpGYFRRALAA---GVDGYVLKDRPIEELADAIRT 114
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
 1-113 1.53e-17

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 75.56  E-value: 1.53e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEPLARERLSRMVnEIEGYRVLedSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVF 80
Cdd:cd17563     1 KSLLLVDDDEVFAERLARAL-ERRGFEVE--TAHSVEEALALAREEKPDYAVLDLRLGGDSGLDLIPPLRALQPDARIVV 77

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1499078941  81 CTAHDEF--ALEAFQVSAVGYLVKPVRAEHLIEAL 113
Cdd:cd17563    78 LTGYASIatAVEAIKLGADDYLAKPADADEILAAL 112
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
 3-115 2.52e-17

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 75.41  E-value: 2.52e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVNEiEGYRVLEdsASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLceREAP-----PA 77
Cdd:cd17562     3 ILAVDDSASIRQMVSFTLRG-AGYEVVE--AADGRDALSKAQSKKFDLIITDQNMPNMDGIELIKEL--RKLPaykftPI 77

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1499078941  78 VVFCT-AHDEFALEAFQVSAVGYLVKPVRAEHLIEALKK 115
Cdd:cd17562    78 LMLTTeSSDEKKQEGKAAGATGWLVKPFDPEQLLEVVKK 116
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
 2-114 4.94e-17

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 74.76  E-value: 4.94e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   2 NVLIVDDEP----LARERLSR--MVNEIEgyrvledSASNGEEALALIEKH-------KPDVVLLDIRMPGIDGLQVAAK 68
Cdd:cd17557     1 TILLVEDNPgdaeLIQEAFKEagVPNELH-------VVRDGEEALDFLRGEgeyadapRPDLILLDLNMPRMDGFEVLRE 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1499078941  69 LceREAP-----PAVVFCTAHDEF-ALEAFQVSAVGYLVKPVRAEHLIEALK 114
Cdd:cd17557    74 I--KADPdlrriPVVVLTTSDAEEdIERAYELGANSYIVKPVDFEEFVEAIR 123
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
3-127 9.23e-17

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 78.74  E-value: 9.23e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVNeIEGYRVLedSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFCT 82
Cdd:PRK11361    7 ILIVDDEDNVRRMLSTAFA-LQGFETH--CANNGRTALHLFADIHPDVVLMDIRMPEMDGIKALKEMRSHETRTPVILMT 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1499078941  83 AHDEF--ALEAFQVSAVGYLVKPVRAEHLIEALKKAerpnrVQLAAM 127
Cdd:PRK11361   84 AYAEVetAVEALRCGAFDYVIKPFDLDELNLIVQRA-----LQLQSM 125
REC_RR468-like cd17552
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and ...
 3-116 4.68e-16

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and similar domains; Thermotoga maritima RR468 (encoded by gene TM0468) is the cognate response regulator (RR) of the class I histidine kinase HK853 (product of gene TM0853). HK853/RR468 comprise a two-component system (TCS) that couples environmental stimuli to adaptive responses. This subfamily also includes Fremyella diplosiphon complementary adaptation response regulator homolog RcaF, a small RR that is involved in four-step phosphorelays of the complementary chromatic adaptation (CCA) system that occurs in many cyanobacteria. Both RR468 and RcaF are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381104 [Multi-domain]  Cd Length: 121  Bit Score: 71.81  E-value: 4.68e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVNEIEGYRVLedSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPA--VVF 80
Cdd:cd17552     4 ILVIDDEEDIREVVQACLEKLAGWEVL--TASSGQEGLEKAATEQPDAILLDVMMPDMDGLATLKKLQANPETQSipVIL 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1499078941  81 CTA----HDEFALEAFQVSAVgyLVKPVRAEHLIEALKKA 116
Cdd:cd17552    82 LTAkaqpSDRQRFASLGVAGV--IAKPFDPLTLAEQIAKL 119
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
 3-114 5.43e-16

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 71.61  E-value: 5.43e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSrMVNEIEGYRVleDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFCT 82
Cdd:cd17615     2 VLVVDDEPNITELLS-MALRYEGWDV--ETAADGAEALAAAREFRPDAVVLDIMLPDMDGLEVLRRLRADGPDVPVLFLT 78

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1499078941  83 AHD--EFALEAFQVSAVGYLVKPVRAEHLIEALK 114
Cdd:cd17615    79 AKDsvEDRIAGLTAGGDDYVTKPFSLEEVVARLR 112
REC_OmpR_CusR-like cd19935
phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; ...
 3-103 6.01e-16

phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; Escherichia coli CusR is part of the CusS/CusR two-component system (TCS) that is involved in response to copper and silver. Other members of this subfamily include Escherichia coli PcoR, Pseudomonas syringae CopR, and Streptomyces coelicolor CutR, which are all transcriptional regulatory proteins and components of TCSs that regulate genes involved in copper resistance and/or metabolism. member of the subfamily is Escherichia coli HprR (hydrogen peroxide response regulator), previously called YdeW, which is part of the HprSR (or YedVW) TCS involved in stress response to hydrogen peroxide, as well as Cupriavidus metallidurans CzcR, which is part of the CzcS/CzcR TCS involved in the control of cobalt, zinc, and cadmium homeostasis. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381162 [Multi-domain]  Cd Length: 100  Bit Score: 70.93  E-value: 6.01e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVNEiEGYRVleDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFCT 82
Cdd:cd19935     1 ILVVEDEKKLAEYLKKGLTE-EGYAV--DVAYDGEDGLHLALTNEYDLIILDVMLPGLDGLEVLRRLRAAGKQTPVLMLT 77

                          90       100
                  ....*....|....*....|....*.
gi 1499078941  83 AHDE-----FALEAfqvSAVGYLVKP 103
Cdd:cd19935    78 ARDSvedrvKGLDL---GADDYLVKP 100
REC_NarL cd19931
phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate ...
 3-116 1.26e-15

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381158 [Multi-domain]  Cd Length: 117  Bit Score: 70.84  E-value: 1.26e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVNEIEGYRVLEDsASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFCT 82
Cdd:cd19931     1 VLLIDDHPLLRKGIKQLIELDPDFTVVGE-ASSGEEGIELAERLDPDLILLDLNMKGMSGLDTLKALREEGVSARIVILT 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1499078941  83 AHD--EFALEAFQVSAVGYLVKPVRAEHLIEALKKA 116
Cdd:cd19931    80 VSDaeDDVVTALRAGADGYLLKDMEPEDLLEALKQA 115
orf27 CHL00148
Ycf27; Reviewed
 1-120 1.48e-15

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 73.60  E-value: 1.48e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEPLARERLSRMVNEIeGYRVLedSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLcEREAPPAVVF 80
Cdd:CHL00148    7 EKILVVDDEAYIRKILETRLSII-GYEVI--TASDGEEALKLFRKEQPDLVILDVMMPKLDGYGVCQEI-RKESDVPIIM 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1499078941  81 CTAHDEFA--LEAFQVSAVGYLVKPVRAEHLiEA-----LKKAERPN 120
Cdd:CHL00148   83 LTALGDVSdrITGLELGADDYVVKPFSPKEL-EArirsvLRRTNKKS 128
PRK09483 PRK09483
response regulator; Provisional
 1-121 1.74e-15

response regulator; Provisional


Pssm-ID: 236538 [Multi-domain]  Cd Length: 217  Bit Score: 72.83  E-value: 1.74e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEPLARERLSRMVNEIEGYRVLeDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVF 80
Cdd:PRK09483    2 INVLLVDDHELVRAGIRRILEDIKGIKVV-GEACCGEDAVKWCRTNAVDVVLMDMNMPGIGGLEATRKILRYTPDVKIIM 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1499078941  81 CTAHDE--FALEAFQVSAVGYLVKPVRAEHLIEALKKAERPNR 121
Cdd:PRK09483   81 LTVHTEnpLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVHSGQR 123
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 1-58 2.08e-15

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 68.36  E-value: 2.08e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1499078941    1 MNVLIVDDEPLARERLSRMvNEIEGYRVLEdsASNGEEALALIEKHKPDVVLLDIRMP 58
Cdd:smart00448   1 MRILVVDDDPLLRELLKAL-LEKEGYEVDE--ATDGEEALELLKEEKPDLILLDIMMP 55
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
 3-114 4.03e-15

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 69.33  E-value: 4.03e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVnEIEGYRVLedSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLceREAPPAVVFC- 81
Cdd:cd17627     1 ILVVDDDRAVRESLRRSL-RFEGYEVE--TAVDGAEALRVISGNRPDAVVLDVMMPRLDGLEVCRRL--RAAGNDLPILv 75

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1499078941  82 -TAHDEFA--LEAFQVSAVGYLVKPVRAEHLIEALK 114
Cdd:cd17627    76 lTARDSVSdrVAGLDAGADDYLVKPFALEELLARVR 111
REC_Spo0F-like cd17553
phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone ...
 3-115 7.82e-15

phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone response regulator containing only a REC domain with no output/effector domain, controls sporulation in Bacillus subtilis through the exchange of a phosphoryl group. Bacillus subtilis forms spores when conditions for growth become unfavorable. The initiation of sporulation is controlled by a phosphorelay (an expanded version of the two-component system) that consists of four main components: a histidine kinase (KinA), a secondary messenger (Spo0F), a phosphotransferase (Spo0B), and a transcription factor (Spo0A). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381105 [Multi-domain]  Cd Length: 117  Bit Score: 68.73  E-value: 7.82e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVNEiEGYRVLEdsASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFCT 82
Cdd:cd17553     3 ILIVDDQYGIRILLNEVFNK-EGYQTFQ--AANGLQALDIVTKERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMT 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1499078941  83 AHDEFAL--EAFQVSAVGYLVKPVRAEHLIEALKK 115
Cdd:cd17553    80 AYGELDMiqESKELGALTHFAKPFDIDEIRDAVKK 114
REC_OmpR_KdpE-like cd17620
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ...
 3-103 1.07e-14

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381135 [Multi-domain]  Cd Length: 99  Bit Score: 67.57  E-value: 1.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLAReRLSRMVNEIEGYRVLEdsASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFcT 82
Cdd:cd17620     1 ILVIEDEPQIR-RFLRTALEAHGYRVFE--AETGQEGLLEAATRKPDLIILDLGLPDMDGLEVIRRLREWSAVPVIVL-S 76

                          90       100
                  ....*....|....*....|...
gi 1499078941  83 AHDEFA--LEAFQVSAVGYLVKP 103
Cdd:cd17620    77 ARDEESdkIAALDAGADDYLTKP 99
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
 2-110 1.90e-14

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 67.41  E-value: 1.90e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   2 NVLIVDDEPLARERLSrMVNEIEGYRVLEdsASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEReAPPAVVFC 81
Cdd:cd17619     2 HILIVEDEPVTRATLK-SYFEQEGYDVSE--AGDGEEMRQILARQDIDLVLLDINLPGKDGLSLTRELREQ-SEVGIILV 77

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1499078941  82 TAHDE-----FALEafqVSAVGYLVKPVRAEHLI 110
Cdd:cd17619    78 TGRDDevdriVGLE---IGADDYVTKPFNPRELL 108
REC_Spo0A cd17561
phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the ...
 2-103 4.91e-14

phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the phosphorelay system in the early stage of spore formation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress and may act in the with sigma factor spo0H to control the expression of some genes that are critical to the sporulation process. Spo0A contains a regulatory N-terminal REC domain and a C-terminal DNA-binding transcription activation domain as its effector/output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381109 [Multi-domain]  Cd Length: 108  Bit Score: 66.09  E-value: 4.91e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   2 NVLIVDDEPLARERLSRMVNEIEGYRVLeDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKL--CEREAPPAVV 79
Cdd:cd17561     3 KVLIADDNREFVQLLEEYLNSQPDMEVV-GVAHNGQEALELIEEKEPDVLLLDIIMPHLDGIGVLEKLrrMRLEKRPKII 81

                          90       100
                  ....*....|....*....|....*.
gi 1499078941  80 FCTA--HDEFALEAFQVSAVGYLVKP 103
Cdd:cd17561    82 MLTAfgQEDITQRAVELGASYYILKP 107
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
 4-86 1.39e-13

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 65.37  E-value: 1.39e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   4 LIVDDEPLARERLSRMVnEIEGYRVLedSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKL--CEREAPPAVVFC 81
Cdd:cd19937     1 LVVDDEEDIVELLKYNL-EKEGYEVV--TAYDGEEALKRAKDEKPDLIILDLMLPGIDGLEVCRILrsDPKTSSIPIIML 77


                  ....*
gi 1499078941  82 TAHDE 86
Cdd:cd19937    78 TAKGE 82
REC_CheY_CheY3 cd19923
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY ...
 1-116 1.96e-13

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY3, Escherichia coli CheY, and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381150 [Multi-domain]  Cd Length: 119  Bit Score: 65.05  E-value: 1.96e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEPLARERLSRMVNEIeGYRVLEDsASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVaAKLCEREA-----P 75
Cdd:cd19923     1 MKVLVVDDFSTMRRIIKNLLKEL-GFNNVEE-AEDGVDALEKLKAGGFDFVITDWNMPNMDGLEL-LKTIRADGalshlP 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1499078941  76 PAVVFCTAHDEFALEAFQVSAVGYLVKPVRAEHLIEALKKA 116
Cdd:cd19923    78 VLMVTAEAKKENVIAAAQAGVNNYIVKPFTAATLKEKLEKI 118
REC_LytTR_AgrA-like cd17533
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; ...
 1-118 3.18e-13

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AgrA-like group of LytTR/AlgR family response regulators are Staphylococcus aureus accessory gene regulator protein A (AgrA) and Streptococcus pneumoniae response regulator ComE, which are members of two-component regulatory systems. AgrA is a global regulator that controls the synthesis of virulence factors and other exoproteins. ComE is part of the ComD-ComE system that is part of a quorum-sensing signaling pathway that controls the development of competence, a physiological state required for genetic transformation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381088 [Multi-domain]  Cd Length: 131  Bit Score: 64.57  E-value: 3.18e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEPLARERLSRMVNEIEGYRVLEDS---ASNGEEALALI---EKHKPDVVLLDIRMPGIDGLQVAAKLCEREA 74
Cdd:cd17533     1 MNIFILEDDKIQRVRLEEIIENILKIENIEYVielTGKTEELLEKIkerGKNGIYFLDIDIKMEEKNGLEVAQKIRKYDP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1499078941  75 PPAVVFCTAHDEFALEAF--QVSAVGYLVKPVRAE----HLIEALKKAER 118
Cdd:cd17533    81 YAIIIFVTTHSEFAPLTFeyKVAALDFILKPLKLEefkkRIEECIKYAQK 130
REC_RocR cd17530
phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR ...
 1-116 5.37e-13

phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR from some pathogens contains an N-terminal phosphoreceiver (REC) domain and a C-terminal EAL domain that possesses c-di-GMP specific phosphodiesterase activity. The RocR REC domain is phosphorylated and modulates its EAL domain enzymatic activity, regulating the local level of c-di-GMP. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381086 [Multi-domain]  Cd Length: 123  Bit Score: 64.00  E-value: 5.37e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEPLARERLSRMVNEIEGYRVleDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVF 80
Cdd:cd17530     1 LRVLVLDDDPFQCMMAATILEDLGPGNV--DEADDGREALVILLCNAPDIIICDLKMPDMDGIEFLRHLAESHSNAAVIL 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1499078941  81 CTAHD-------EFALEAFQVSAVGYLVKPVRAEHLIEALKKA 116
Cdd:cd17530    79 MSGLDggilesaETLAGANGLNLLGTLSKPFSPEELTELLTKY 121
PRK15369 PRK15369
two component system response regulator;
2-116 1.21e-12

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 64.71  E-value: 1.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   2 NVLIVDDEPLARERLSRMVNEIEGYRVLEdSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFC 81
Cdd:PRK15369    5 KILLVDDHELIINGIKNMLAPYPRYKIVG-QVDNGLEVYNACRQLEPDIVILDLGLPGMNGLDVIPQLHQRWPAMNILVL 83

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1499078941  82 TAHDE--FALEAFQVSAVGYLVKPVRAEHLIEALKKA 116
Cdd:PRK15369   84 TARQEehMASRTLAAGALGYVLKKSPQQILLAAIQTV 120
pleD PRK09581
response regulator PleD; Reviewed
 3-104 1.62e-12

response regulator PleD; Reviewed


Pssm-ID: 236577 [Multi-domain]  Cd Length: 457  Bit Score: 66.46  E-value: 1.62e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPlARERL--SRMVNEIegYRVLedSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVaaklCER-EAPPA-- 77
Cdd:PRK09581    5 ILVVDDIP-ANVKLleAKLLAEY--YTVL--TASSGAEAIAICEREQPDIILLDVMMPGMDGFEV----CRRlKSDPAtt 75

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1499078941  78 ---VVFCTAHDEFA-----LEAfqvSAVGYLVKPV 104
Cdd:PRK09581   76 hipVVMVTALDDPEdrvrgLEA---GADDFLTKPI 107
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
 4-110 1.76e-12

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 62.24  E-value: 1.76e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   4 LIVDDEPLARERLSRMVNEiEGYRVleDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFCTA 83
Cdd:cd17625     1 LVVEDEKDLSEAITKHLKK-EGYTV--DVCFDGEEGLEYALSGIYDLIILDIMLPGMDGLEVLKSLREEGIETPVLLLTA 77

                          90       100
                  ....*....|....*....|....*....
gi 1499078941  84 HDEFA--LEAFQVSAVGYLVKPVRAEHLI 110
Cdd:cd17625    78 LDAVEdrVKGLDLGADDYLPKPFSLAELL 106
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
3-145 3.08e-12

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 63.72  E-value: 3.08e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVNEIEGYRVLEDsASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFCT 82
Cdd:PRK10403    9 VLIVDDHPLMRRGVRQLLELDPGFEVVAE-AGDGASAIDLANRLDPDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILT 87

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1499078941  83 ----AHDEFALeaFQVSAVGYLVKPVRAEHLIEALKKAER-----PNRVQLAAMTRPAAESGSGPRTHISAR 145
Cdd:PRK10403   88 vsdaSSDVFAL--IDAGADGYLLKDSDPEVLLEAIRAGAKgskvfSERVNQYLREREMFGAEEDPFSVLTER 157
REC_Ycf29 cd19927
phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a ...
 3-103 3.18e-12

phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a probable response regulator of a two-component system (TCS), typically consisting a sensor and a response regulator, that functions in adaptation to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Ycf29 contains an N-terminal REC domain and a LuxR-type helix-turn-helix DNA-binding output domain. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381154 [Multi-domain]  Cd Length: 102  Bit Score: 61.24  E-value: 3.18e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVNEIeGYRVleDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLceREAP-----Pa 77
Cdd:cd19927     1 ILLVDDDPGIRLAVKDYLEDQ-GFTV--IAASNGLEALDLLNQYIPDLIISDIIMPGVDGYSLLGKL--RKNAdfdtiP- 74

                          90       100
                  ....*....|....*....|....*...
gi 1499078941  78 VVFCTAHDEFA--LEAFQVSAVGYLVKP 103
Cdd:cd19927    75 VIFLTAKGMTSdrIKGYNAGCDGYLSKP 102
REC_OmpR_EcPhoP-like cd19934
phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; ...
 3-110 3.19e-12

phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; Escherichia coli PhoP (EcPhoP) is part of the PhoQ/PhoP two-component system (TCS) that regulates virulence genes and plays an essential role in the response of the bacteria to the environment of their mammalian hosts, sensing several stimuli such as extracellular magnesium limitation, low pH, the presence of cationic antimicrobial peptides, and osmotic upshift. This subfamily also includes Brucella suis FeuP, part of the FeuPQ TCS that is involved in the regulation of iron uptake, and Microchaete diplosiphon RcaC, which is required for chromatic adaptation. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381161 [Multi-domain]  Cd Length: 117  Bit Score: 61.53  E-value: 3.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVNEiEGYRVleDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFCT 82
Cdd:cd19934     1 LLLVEDDALLAAQLKEQLSD-AGYVV--DVAEDGEEALFQGEEEPYDLVVLDLGLPGMDGLSVLRRWRSEGRATPVLILT 77

                          90       100       110
                  ....*....|....*....|....*....|
gi 1499078941  83 AHDEFA--LEAFQVSAVGYLVKPVRAEHLI 110
Cdd:cd19934    78 ARDSWQdkVEGLDAGADDYLTKPFHIEELL 107
REC_typeB_ARR-like cd17584
phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and ...
 3-109 5.96e-12

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381121 [Multi-domain]  Cd Length: 115  Bit Score: 60.72  E-value: 5.96e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVNEIeGYRVleDSASNGEEALALIEKHKP--DVVLLDIRMPGIDGLQVAAKLCEREAPPaVVF 80
Cdd:cd17584     1 VLVVDDDPTCLAILKRMLLRC-GYQV--TTCTDAEEALSMLRENKDefDLVITDVHMPDMDGFEFLELIRLEMDLP-VIM 76

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1499078941  81 CTAHDEFA--LEAFQVSAVGYLVKPVRAEHL 109
Cdd:cd17584    77 MSADGSTStvMKGLAHGACDYLLKPVSIEDL 107
fixJ PRK09390
response regulator FixJ; Provisional
 2-116 6.52e-12

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 62.71  E-value: 6.52e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   2 NVLIVDDEPLARERLSRMVnEIEGYRV-LEDSASNGEEALALIEkhkPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVF 80
Cdd:PRK09390    5 VVHVVDDDEAMRDSLAFLL-DSAGFEVrLFESAQAFLDALPGLR---FGCVVTDVRMPGIDGIELLRRLKARGSPLPVIV 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1499078941  81 CTAHDE--FALEAFQVSAVGYLVKPVRAEHLIEALKKA 116
Cdd:PRK09390   81 MTGHGDvpLAVEAMKLGAVDFIEKPFEDERLIGAIERA 118
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
 3-114 7.36e-12

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 60.51  E-value: 7.36e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVNEiEGYRVLedSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFCT 82
Cdd:cd17614     1 ILVVDDEKPISDILKFNLTK-EGYEVV--TAYDGREALEKVEEEQPDLILLDLMLPEKDGLEVCREVRKTSNVPIIMLTA 77

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1499078941  83 AHDEF-ALEAFQVSAVGYLVKPVRAEHLIEALK 114
Cdd:cd17614    78 KDSEVdKVLGLELGADDYVTKPFSNRELLARVK 110
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
 3-110 8.32e-12

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 60.19  E-value: 8.32e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVNEiEGYRVleDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFCT 82
Cdd:cd17624     1 ILLVEDDALLGDGLKTGLRK-AGYAV--DWVRTGAEAEAALASGPYDLVILDLGLPDGDGLDLLRRWRRQGQSLPVLILT 77

                          90       100       110
                  ....*....|....*....|....*....|
gi 1499078941  83 AHDEFA--LEAFQVSAVGYLVKPVRAEHLI 110
Cdd:cd17624    78 ARDGVDdrVAGLDAGADDYLVKPFALEELL 107
PRK15115 PRK15115
response regulator GlrR; Provisional
 2-116 1.17e-11

response regulator GlrR; Provisional


Pssm-ID: 185070 [Multi-domain]  Cd Length: 444  Bit Score: 63.70  E-value: 1.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   2 NVLIVDDEPlARERLSRMVNEIEGYRVLedSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFC 81
Cdd:PRK15115    7 HLLLVDDDP-GLLKLLGMRLTSEGYSVV--TAESGQEALRVLNREKVDLVISDLRMDEMDGMQLFAEIQKVQPGMPVIIL 83

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1499078941  82 TAHDEF--ALEAFQVSAVGYLVKPVRAEHLIEALKKA 116
Cdd:PRK15115   84 TAHGSIpdAVAATQQGVFSFLTKPVDRDALYKAIDDA 120
dpiA PRK10046
two-component response regulator DpiA; Provisional
 1-122 1.72e-11

two-component response regulator DpiA; Provisional


Pssm-ID: 182208 [Multi-domain]  Cd Length: 225  Bit Score: 61.96  E-value: 1.72e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEPLARERLSRMVNEIEGYRVLEdSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVF 80
Cdd:PRK10046    5 LTLLIVEDETPLAEMHAEYIRHIPGFSQIL-LAGNLAQARMMIERFKPGLILLDNYLPDGRGINLLHELVQAHYPGDVVF 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1499078941  81 CTAHD--EFALEAFQVSAVGYLVKPVRAEHLIEALKKAERPNRV 122
Cdd:PRK10046   84 TTAASdmETVSEAVRCGVFDYLIKPIAYERLGQTLTRFRQRKHM 127
PRK15347 PRK15347
two component system sensor kinase;
1-113 1.91e-11

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 63.51  E-value: 1.91e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEPLARERLSRMVNEIeGYRVleDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAA------KLCEREA 74
Cdd:PRK15347  691 LQILLVDDVETNRDIIGMMLVEL-GQQV--TTAASGTEALELGRQHRFDLVLMDIRMPGLDGLETTQlwrddpNNLDPDC 767

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1499078941  75 PpaVVFCTAHDEfALEAFQVSAVG---YLVKPVRAEHLIEAL 113
Cdd:PRK15347  768 M--IVALTANAA-PEEIHRCKKAGmnhYLTKPVTLAQLARAL 806
REC_2_GGDEF cd17544
second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This ...
 1-69 2.05e-11

second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins, described in this model, contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381098 [Multi-domain]  Cd Length: 122  Bit Score: 59.45  E-value: 2.05e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1499078941   1 MNVLIVDDEPLARERLSRMVnEIEGYRVLEdsASNGEEALALIEKHkPDV--VLLDIRMPGIDGLQVAAKL 69
Cdd:cd17544     1 IKVLVVDDSATSRNHLRALL-RRHNFQVLE--AANGQEALEVLEQH-PDIklVITDYNMPEMDGFELVREI 67
PRK10766 PRK10766
two-component system response regulator TorR;
2-72 2.06e-11

two-component system response regulator TorR;


Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 61.59  E-value: 2.06e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1499078941   2 NVLIVDDEPLARERLSRMVnEIEGYRVLEdsASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCER 72
Cdd:PRK10766    4 HILVVEDEPVTRARLQGYF-EQEGYTVSE--AASGAGMREIMQNQHVDLILLDINLPGEDGLMLTRELRSR 71
REC_hyHK cd17598
phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase ...
 3-72 2.86e-11

phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase/response regulators; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase/response regulators contain all the elements of a classical TCS in a single polypeptide chain. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381128 [Multi-domain]  Cd Length: 118  Bit Score: 58.88  E-value: 2.86e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLsRMVNEIEGYRVLedSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQvaakLCER 72
Cdd:cd17598     1 ILIVEDSPTQAEQL-KHILEEQGYKVQ--VARNGREALAMLAEHRPTLVISDIVMPEMDGYE----LCRK 63
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 2-114 3.08e-11

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 58.80  E-value: 3.08e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   2 NVLIVDDEPLARErLSRMVNEIEGYRVLEdsASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCE----REAPpa 77
Cdd:cd17618     2 TILIVEDEPAIRE-MIAFNLERAGFDVVE--AEDAESAVNLIVEPRPDLILLDWMLPGGSGIQFIRRLKRdemtRDIP-- 76

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1499078941  78 VVFCTAHDEFA--LEAFQVSAVGYLVKPVRAEHLIEALK 114
Cdd:cd17618    77 IIMLTARGEEEdkVRGLEAGADDYITKPFSPRELVARIK 115
REC_hyHK_blue-like cd18161
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators ...
 3-104 3.47e-11

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators similar to Pseudomonas savastanoi blue-light-activated histidine kinase; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase (HK)/response regulators contain all the elements of a classical TCS in a single polypeptide chain. Pseudomonas savastanoi blue-light-activated histidine kinase is a photosensitive HK and RR that is involved in increased bacterial virulence upon exposure to light. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381145 [Multi-domain]  Cd Length: 102  Bit Score: 58.51  E-value: 3.47e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVNEIeGYRVLEdsASNGEEALALIEKH-KPDVVLLDIRMPG-IDGLQVAAKLCEREAPPAVVF 80
Cdd:cd18161     1 VLVVEDDPDVRRLTAEVLEDL-GYTVLE--AASGDEALDLLESGpDIDLLVTDVIMPGgMNGSQLAEEARRRRPDLKVLL 77

                          90       100
                  ....*....|....*....|....*
gi 1499078941  81 CTAHDEFALEA-FQVSAVGYLVKPV 104
Cdd:cd18161    78 TSGYAENAIEGgDLAPGVDVLSKPF 102
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
1-117 3.69e-11

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 60.68  E-value: 3.69e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEPLARERLSRMV--NEIEGYRVLEDSASngeeALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAV 78
Cdd:PRK09958    1 MNAIIIDDHPLAIAAIRNLLikNDIEILAELTEGGS----AVQRVETLKPDIVIIDVDIPGVNGIQVLETLRKRQYSGII 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1499078941  79 VFCTAHDE--FALEAFQVSAVGYLVKPVRAEHLIEALKKAE 117
Cdd:PRK09958   77 IIVSAKNDhfYGKHCADAGANGFVSKKEGMNNIIAAIEAAK 117
spore_0_A TIGR02875
sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a ...
 3-109 4.63e-11

sporulation transcription factor Spo0A; Spo0A, the stage 0 sporulation protein A, is a transcription factor critical for the initiation of sporulation. It contains a response regulator receiver domain (pfam00072). In Bacillus subtilis, it works together with response regulator Spo0F and the phosphotransferase Spo0B, both of which are missing from at least some sporulating species and thus not part of the endospore forming bacteria minimal gene set. Spo0A, however, is universal among endospore-forming species. [Cellular processes, Sporulation and germination]


Pssm-ID: 131922 [Multi-domain]  Cd Length: 262  Bit Score: 61.35  E-value: 4.63e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVNEIEGYRVLeDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKL--CEREAPPAVVF 80
Cdd:TIGR02875   5 IVIADDNKEFCNLLKEYLAAQPDMEVV-GVAHNGVDALELIKEQQPDVVVLDIIMPHLDGIGVLEKLneIELSARPRVIM 83

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1499078941  81 CTA--HDEFALEAFQVSAVGYLVKPVRAEHL 109
Cdd:TIGR02875  84 LSAfgQEKITQRAVALGADYYVLKPFDLEIL 114
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
 2-142 8.21e-11

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 61.43  E-value: 8.21e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   2 NVLIVDDEPLARERLSRmvnEIEGYRVLEDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFC 81
Cdd:PRK10923    5 IVWVVDDDSSIRWVLER---ALAGAGLTCTTFENGNEVLEALASKTPDVLLSDIRMPGMDGLALLKQIKQRHPMLPVIIM 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1499078941  82 TAHDEF--ALEAFQVSAVGYLVKPVRAEHLIEALKKAERPNRVQlaamTRPAAESGSGPRTHI 142
Cdd:PRK10923   82 TAHSDLdaAVSAYQQGAFDYLPKPFDIDEAVALVERAISHYQEQ----QQPRNIQVNGPTTDI 140
REC_HupR cd17596
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of ...
 3-123 1.19e-10

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of this subfamily are response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It belongs to the nitrogen regulatory protein C (NtrC) family of response regulators, which activate transcription by RNA polymerase (RNAP) in response to a change in the environment. HupR is an unusual member of this family as it activates transcription when unphosphorylated, and transcription is inhibited by phosphorylation. Proteins in this subfamily contain an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381127 [Multi-domain]  Cd Length: 133  Bit Score: 57.76  E-value: 1.19e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVNEieGYRVLedSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFCT 82
Cdd:cd17596     3 ILVVDDEVRSLEALRRTLEE--DFDVL--TAASAEEALAILEEEWVQVILCDQRMPGTTGVEFLKEVRERWPEVVRIIIS 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1499078941  83 AHDEFALEAFQVSAVG---YLVKPVRAEHLIEALKKAERPNRVQ 123
Cdd:cd17596    79 GYTDSEDIIAGINEAGiyqYLTKPWHPDQLLLTVRNAARLFELQ 122
PRK11173 PRK11173
two-component response regulator; Provisional
 2-110 3.73e-10

two-component response regulator; Provisional


Pssm-ID: 183013 [Multi-domain]  Cd Length: 237  Bit Score: 58.10  E-value: 3.73e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   2 NVLIVDDEPLARERLsRMVNEIEGYRVLEdsASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEReAPPAVVFC 81
Cdd:PRK11173    5 HILIVEDELVTRNTL-KSIFEAEGYDVFE--ATDGAEMHQILSENDINLVIMDINLPGKNGLLLARELREQ-ANVALMFL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1499078941  82 TAHDE-----FALEafqVSAVGYLVKP-------VRAEHLI 110
Cdd:PRK11173   81 TGRDNevdkiLGLE---IGADDYITKPfnpreltIRARNLL 118
REC_CheV-like cd19924
phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This ...
 3-103 9.40e-10

phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This subfamily includes the REC domains of Bacillus subtilis chemotaxis protein CheV, Myxococcus xanthus gliding motility regulatory protein FrzE, and similar proteins. CheV is a hybrid protein with an N-terminal CheW-like domain and a C-terminal CheY-like REC domain. The CheV pathway is one of three systems employed by B. subtilis for sensory adaptation that contribute to chemotaxis. It is involved in the transmission of sensory signals from chemoreceptors to flagellar motors. Together with CheW, it is involved in the coupling of methyl-accepting chemoreceptors to the central two-component histidine kinase CheA. FrzE is a hybrid sensor histidine kinase/response regulator that is part of the Frz pathway that controls cell reversal frequency to support directional motility during swarming and fruiting body formation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381151 [Multi-domain]  Cd Length: 111  Bit Score: 54.69  E-value: 9.40e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVNEIeGYRVleDSASNGEEALALIEKHKP---------DVVLLDIRMPGIDGLQVAAKLceRE 73
Cdd:cd19924     1 ILVVDDSPTARKQLRDLLKNL-GFEI--AEAVDGEEALNKLENLAKegndlskelDLIITDIEMPKMDGYELTFEL--RD 75

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1499078941  74 AP-----PAVVFCTAHDEFALE-AFQVSAVGYLVKP 103
Cdd:cd19924    76 DPrlaniPVILNSSLSGEFSRArGKKVGADAYLAKF 111
REC_CpdR_CckA-like cd18160
phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; ...
 3-103 1.14e-09

phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; Two-component systems (TCSs), consisting of a sensor and a response regulator, are used by bacteria to adapt to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis and membrane transport. Response regulators share the common phosphoacceptor REC domain and differ output domains such as DNA, RNA, ligand, and protein-binding, or enzymatic domain. CpdR is a stand-alone REC protein. CckA is a sensor histidine kinase containing N-terminal PAS domains and a C-terminal REC domain. CpdR and CckA are components of a regulatory phosphorelay system (composed of CckA, ChpT, CtrA and CpdR) that controls Brucella abortus cell growth, division, and intracellular survival inside mammalian host cells. CckA autophosphorylates in the presence of ATP and transfers a phosphoryl group to the conserved aspartic acid residue on its C-terminal REC domain, which is relayed to the ChpT phosphotransferase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381144 [Multi-domain]  Cd Length: 103  Bit Score: 54.43  E-value: 1.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVnEIEGYRVLEdsASNGEEALALIEKHKP-DVVLLDIRMPGIDGLQVAAKLceREAPPAV--V 79
Cdd:cd18160     2 ILLADDEPSVRKFIVTTL-KKAGYAVTE--AESGAEALEKLQQGKDiDIVVTDIVMPEMDGIELAREA--RKIDPDVkiL 76

                          90       100
                  ....*....|....*....|....*.
gi 1499078941  80 FCTAH--DEFALEAFQVSAVGYLVKP 103
Cdd:cd18160    77 FISGGaaAAPELLSDAVGDNATLKKP 102
REC_OmpR_ChvI-like cd19936
phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; ...
 3-103 1.61e-09

phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; Sinorhizobium meliloti ChvI is part of the ExoS/ChvI two-component regulatory system (TCS) that is required for nitrogen-fixing symbiosis and exopolysaccharide synthesis. ExoS/ChvI also play important roles in regulating biofilm formation, motility, nutrient utilization, and the viability of free-living bacteria. ChvI belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381163 [Multi-domain]  Cd Length: 99  Bit Score: 53.60  E-value: 1.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSrMVNEIEGYRVleDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPaVVFCT 82
Cdd:cd19936     1 IALVDDDRNILTSVS-MALEAEGFSV--ETYTDGASALDGLNARPPDLAILDIKMPRMDGMELLQRLRQKSTLP-VIFLT 76

                          90       100
                  ....*....|....*....|...
gi 1499078941  83 AHDEFALEAF--QVSAVGYLVKP 103
Cdd:cd19936    77 SKDDEIDEVFglRMGADDYITKP 99
REC_PhyR cd17540
phosphoacceptor receiver (REC) domain of response regulator PhyR and similar proteins; PhyR is ...
 3-116 5.57e-09

phosphoacceptor receiver (REC) domain of response regulator PhyR and similar proteins; PhyR is a hybrid stress regulator that contains an N-terminal sigma-like (SL) domain and a C-terminal REC domain. Phosphorylation of the REC domain is known to promote binding of the SL domain to an anti-sigma factor. PhyR thus functions as an anti-anti-sigma factor in its phosphorylated state. It is involved in the general stress response. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381095 [Multi-domain]  Cd Length: 117  Bit Score: 52.64  E-value: 5.57e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVNEIeGYRVLEDSASNGEeALALIEKHKPDVVLLDIRM----PGIDGlqVAAKLCEREAPpaV 78
Cdd:cd17540     3 VLIIEDEPLIAMDLEQIVEDL-GHQVVGIARTRDE-AVALARRERPDLILADIQLadgsSGIDA--VNEILTTHDVP--V 76

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1499078941  79 VFCTAHDEFALEAFQVSAVgYLV-KPVRAEHLIEALKKA 116
Cdd:cd17540    77 IFVTAYPERLLTGERPEPT-FLItKPFDPEMVKAAISQA 114
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 1-84 6.02e-09

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 56.01  E-value: 6.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEP----LARERLSRMVNEIEgyrvledSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQvAAKL-----CE 71
Cdd:PRK11107  668 LTVMAVDDNPanlkLIGALLEEQVEHVV-------LCDSGHQAVEQAKQRPFDLILMDIQMPGMDGIR-ACELirqlpHN 739

                          90
                  ....*....|...
gi 1499078941  72 REAPpaVVFCTAH 84
Cdd:PRK11107  740 QNTP--IIAVTAH 750
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
 3-118 6.73e-09

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 52.31  E-value: 6.73e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVnEIEGYRVleDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPaVVFCT 82
Cdd:cd17623     1 ILLIDDDRELTELLTEYL-EMEGFNV--RAAHDGEQGLAALLEGSPDLVVLDVMLPKMNGLDVLKELRKTSQVP-VLMLT 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1499078941  83 AHDE-----FALEafqVSAVGYLVKPVRAEHLIEALKKAER 118
Cdd:cd17623    77 ARGDdidriLGLE---LGADDYLPKPFNPRELVARIRAILR 114
PRK11517 PRK11517
DNA-binding response regulator HprR;
1-103 1.37e-08

DNA-binding response regulator HprR;


Pssm-ID: 183172 [Multi-domain]  Cd Length: 223  Bit Score: 53.75  E-value: 1.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEPLARERLSRMVNEiEGYRVleDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLceREAPPAVVF 80
Cdd:PRK11517    1 MKILLIEDNQRTQEWVTQGLSE-AGYVI--DAVSDGRDGLYLALKDDYALIILDIMLPGMDGWQILQTL--RTAKQTPVI 75

                          90       100
                  ....*....|....*....|....*.
gi 1499078941  81 C-TAHD--EFALEAFQVSAVGYLVKP 103
Cdd:PRK11517   76 ClTARDsvDDRVRGLDSGANDYLVKP 101
PRK10816 PRK10816
two-component system response regulator PhoP;
1-120 1.84e-08

two-component system response regulator PhoP;


Pssm-ID: 182755 [Multi-domain]  Cd Length: 223  Bit Score: 53.20  E-value: 1.84e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEPLARERLSRMVNEIeGYRVleDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVF 80
Cdd:PRK10816    1 MRVLVVEDNALLRHHLKVQLQDA-GHQV--DAAEDAKEADYYLNEHLPDIAIVDLGLPDEDGLSLIRRWRSNDVSLPILV 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1499078941  81 CTAHDEF--ALEAFQVSAVGYLVKPVRAEHLIEALKKAERPN 120
Cdd:PRK10816   78 LTARESWqdKVEVLSAGADDYVTKPFHIEEVMARMQALMRRN 119
REC_OmpR_kpRstA-like cd17622
phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; ...
 3-104 2.06e-08

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381137 [Multi-domain]  Cd Length: 116  Bit Score: 51.23  E-value: 2.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPlareRLSRMVN---EIEGYRVLEdsASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVV 79
Cdd:cd17622     3 ILLVEDDP----KLARLIAdflESHGFNVVV--EHRGDRALEVIAREKPDAVLLDIMLPGIDGLTLCRDLRPKYQGPILL 76

                          90       100
                  ....*....|....*....|....*.
gi 1499078941  80 FCTAHDEF-ALEAFQVSAVGYLVKPV 104
Cdd:cd17622    77 LTALDSDIdHILGLELGADDYVVKPV 102
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 1-115 2.38e-08

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 54.18  E-value: 2.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEPL----ARERLSRMVNEIegyrvleDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCER---E 73
Cdd:PRK11091  526 LNILLVEDIELnvivARSVLEKLGNSV-------DVAMTGKEALEMFDPDEYDLVLLDIQLPDMTGLDIARELRERyprE 598

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1499078941  74 APPAVVFCTAH-----DEFaleaFQVSAVGYLVKPVRAEHLIEALKK 115
Cdd:PRK11091  599 DLPPLVALTANvlkdkKEY----LDAGMDDVLSKPLSVPALTAMIKK 641
PRK10610 PRK10610
chemotaxis protein CheY;
1-115 2.55e-08

chemotaxis protein CheY;


Pssm-ID: 170568 [Multi-domain]  Cd Length: 129  Bit Score: 51.13  E-value: 2.55e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEPLARERLSRMVNEIeGYRVLEDsASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREA----PP 76
Cdd:PRK10610    6 LKFLVVDDFSTMRRIVRNLLKEL-GFNNVEE-AEDGVDALNKLQAGGFGFVISDWNMPNMDGLELLKTIRADGAmsalPV 83

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1499078941  77 AVVFCTAHDEFALEAFQVSAVGYLVKPVRAEHLIEALKK 115
Cdd:PRK10610   84 LMVTAEAKKENIIAAAQAGASGYVVKPFTAATLEEKLNK 122
PRK10365 PRK10365
sigma-54-dependent response regulator transcription factor ZraR;
1-116 5.53e-08

sigma-54-dependent response regulator transcription factor ZraR;


Pssm-ID: 182412 [Multi-domain]  Cd Length: 441  Bit Score: 52.73  E-value: 5.53e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEpLARERLSRMVNEIEGYRVLedSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVF 80
Cdd:PRK10365    6 IDILVVDDD-ISHCTILQALLRGWGYNVA--LANSGRQALEQVREQVFDLVLCDVRMAEMDGIATLKEIKALNPAIPVLI 82

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1499078941  81 CTAHD--EFALEAFQVSAVGYLVKPVRAEHLIEALKKA 116
Cdd:PRK10365   83 MTAYSsvETAVEALKTGALDYLIKPLDFDNLQATLEKA 120
PRK10430 PRK10430
two-component system response regulator DcuR;
1-113 5.59e-08

two-component system response regulator DcuR;


Pssm-ID: 182454 [Multi-domain]  Cd Length: 239  Bit Score: 52.03  E-value: 5.59e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEPLARERLSRMVNEIEGYRVLeDSASNGEEALALI---EKHKpDVVLLDIRMPGIDGLQVAAKLCE-REAPP 76
Cdd:PRK10430    2 INVLIVDDDAMVAELNRRYVAQIPGFQCC-GTASTLEQAKEIIfnsDTPI-DLILLDIYMQQENGLDLLPVLHEaGCKSD 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1499078941  77 AVVFCTAHDEFALE-AFQVSAVGYLVKPVRAEHLIEAL 113
Cdd:PRK10430   80 VIVISSAADAATIKdSLHYGVVDYLIKPFQASRFEEAL 117
REC_OmpR_RegX3-like cd17621
phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is ...
 3-103 6.25e-08

phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is a member of the SenX3-RegX3 two-component system that is involved in phosphate-sensing signal transduction. Phosphorylated RegX3 functions as a transcriptional activator of phoA. It induces transcription in phosphate limiting environment and also controls expression of several critical metabolic enzymes in aerobic condition. RegX3 belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381136 [Multi-domain]  Cd Length: 99  Bit Score: 49.50  E-value: 6.25e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVNEiEGYRVLedSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFCT 82
Cdd:cd17621     1 VLVVEDEESFSDPLAYLLRK-EGFEVT--VATDGPAALAEFDRAGADIVLLDLMLPGLSGTEVCRQLRARSNVPVIMVTA 77

                          90       100
                  ....*....|....*....|..
gi 1499078941  83 AHDEF-ALEAFQVSAVGYLVKP 103
Cdd:cd17621    78 KDSEIdKVVGLELGADDYVTKP 99
PRK13557 PRK13557
histidine kinase; Provisional
 3-90 1.01e-07

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 51.98  E-value: 1.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARErLSRMVNEIEGYRVLedSASNGEEALALIEKH-KPDVVLLDIRMPG-IDGLQVAAKLCEREAPPAVVF 80
Cdd:PRK13557  418 ILIVDDRPDVAE-LARMILEDFGYRTL--VASNGREALEILDSHpEVDLLFTDLIMPGgMNGVMLAREARRRQPKIKVLL 494

                          90
                  ....*....|
gi 1499078941  81 CTAHDEFALE 90
Cdd:PRK13557  495 TTGYAEASIE 504
REC_OmpR_BfmR-like cd19939
phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; ...
 3-110 1.15e-07

phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; Acinetobacter baumannii BfmR is part of the BfmR/S two-component system that functions as the master regulator of biofilm initiation. BfmR confers resistance to complement-mediated bactericidal activity, independent of capsular polysaccharide, and also increases resistance to the clinically important antimicrobials meropenem and colistin, making it a potential antimicrobial target. Its inhibition would have the dual benefit of significantly decreasing in vivo survival and increasing sensitivity to selected antimicrobials. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381166 [Multi-domain]  Cd Length: 116  Bit Score: 48.91  E-value: 1.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEplarERLSRMVNEIEGYRVLEDSA-SNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFC 81
Cdd:cd19939     2 ILIVEDE----LELARLTRDYLIKAGLEVSVfTDGQRAVRRIIDEQPSLVVLDIMLPGMDGLTVCREVREHSHVPILMLT 77

                          90       100       110
                  ....*....|....*....|....*....|
gi 1499078941  82 TAHDEF-ALEAFQVSAVGYLVKPVRAEHLI 110
Cdd:cd19939    78 ARTEEMdRVLGLEMGADDYLCKPFSPRELL 107
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
1-69 1.26e-07

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 51.90  E-value: 1.26e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1499078941   1 MNVLIVDDEPLARERLSRMVNEIeGYRVLedSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKL 69
Cdd:PRK10841  802 MMILVVDDHPINRRLLADQLGSL-GYQCK--TANDGVDALNVLSKNHIDIVLTDVNMPNMDGYRLTQRL 867
REC_WspR-like cd17575
phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The ...
 3-102 1.41e-07

phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The GGDEF response regulator WspR is part of the Wsp system that is homologous to chemotaxis systems and also includes the membrane-bound receptor protein WspA. In response to growth on surfaces, WspR is phosphorylated by the Wsp signal transduction complex and is activated, functioning as a diguanylate cyclase (DGC) that catalyzes c-di-GMP synthesis. WspR is a hybrid response regulator-diguanylate cyclase, containing an N-terminal REC domain and a C-terminal GGDEF domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381117 [Multi-domain]  Cd Length: 128  Bit Score: 48.94  E-value: 1.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVNEIEgyRVLEDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVA----AKLCEREAPPAV 78
Cdd:cd17575     3 VLLVDDQAIIGEAVRRALADEE--DIDFHYCSDPTEAIEVASQIKPTVILQDLVMPGVDGLTLVrffrANPATRDIPIIV 80

                          90       100
                  ....*....|....*....|....
gi 1499078941  79 VFCTAHDEFALEAFQVSAVGYLVK 102
Cdd:cd17575    81 LSTKEEPEVKSEAFALGANDYLVK 104
REC_PilR cd19926
phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR ...
 3-103 1.86e-07

phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR and similar proteins; Pseudomonas aeruginosa PilR is the response regulator of the PilS/PilR two-component regulatory system (PilSR TCS) that acts in conjunction with sigma-54 to regulate the expression of type 4 pilus (T4P) major subunit PilA. In addition, the PilSR TCS regulates flagellum-dependent swimming motility and pilus-dependent twitching motility. PilR contains an N-terminal REC domain, a central sigma-54 interaction domain, and a C-terminal Fis-type helix-turn-helix DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381153 [Multi-domain]  Cd Length: 100  Bit Score: 47.92  E-value: 1.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARE----RLSRMvneieGYRVLedSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCER--EAPP 76
Cdd:cd19926     1 VLVVDDEPDIRElleiTLGRM-----GLDVR--SARNVKEARELLASEPYDLCLTDMRLPDGSGLELVQHIQQRlpQTPV 73

                          90       100
                  ....*....|....*....|....*..
gi 1499078941  77 AVVFCTAHDEFALEAFQVSAVGYLVKP 103
Cdd:cd19926    74 AVITAYGSLDTAIEALKAGAFDFLTKP 100
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
 3-110 2.09e-07

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 48.23  E-value: 2.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSrMVNEIEGYRVLedSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFCT 82
Cdd:cd17626     3 ILVVDDDAALAEMIG-IVLRGEGFDPA--FCGDGTQALAAFREVRPDLVLLDLMLPGIDGIEVCRQIRAESGVPIVMLTA 79

                          90       100
                  ....*....|....*....|....*....
gi 1499078941  83 AHDEF-ALEAFQVSAVGYLVKPVRAEHLI 110
Cdd:cd17626    80 KSDTVdVVLGLESGADDYVAKPFKPKELV 108
REC_TPR cd17589
phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR) ...
 3-113 2.12e-07

phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR)-containing response regulators; Response regulators share the common phosphoacceptor REC domain and different output domains. This subfamily contains uncharacterized response regulators with TPR repeats as the effector or output domain, which might contain between 3 to 16 TPR repeats (each about 34 amino acids). TPR-containing proteins occur in all domains of life and the abundance of TPR-containing proteins in a bacterial proteome is not indicative of virulence. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members in this subfamily may contain inactive REC domains lacking canonical metal-binding and active site residues.


Pssm-ID: 381123 [Multi-domain]  Cd Length: 115  Bit Score: 48.41  E-value: 2.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVNEIEGYRVleDSASNGEEALALIEKHKPDVVLLDIRM-PGIDGLQVAAKLCERE--APPAVV 79
Cdd:cd17589     1 FLIVDDQPTFRSMLKSMLRSLGVTRI--DTASSGEEALRMCENKTYDIVLCDYNLgKGKNGQQLLEELRHKKliSPSTVF 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1499078941  80 FCT---AHDEFALEAFQVSAVGYLVKPVRAEHLIEAL 113
Cdd:cd17589    79 IMVtgeSSRAMVLSALELEPDDYLLKPFTVSELRERL 115
PRK09191 PRK09191
two-component response regulator; Provisional
 2-86 2.40e-07

two-component response regulator; Provisional


Pssm-ID: 236402 [Multi-domain]  Cd Length: 261  Bit Score: 50.23  E-value: 2.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   2 NVLIVDDEPLARERLSRMVNEIeGYRVLeDSASNGEEALALIEKHKPDVVLLDIRM-PGIDGLQ-VAAKLCEREAPpaVV 79
Cdd:PRK09191  139 RVLIIEDEPIIAMDLEQLVESL-GHRVT-GIARTRAEAVALAKKTRPGLILADIQLaDGSSGIDaVNDILKTFDVP--VI 214


                  ....*..
gi 1499078941  80 FCTAHDE 86
Cdd:PRK09191  215 FITAFPE 221
ompR PRK09468
osmolarity response regulator; Provisional
 3-103 4.19e-07

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 49.59  E-value: 4.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVNEiEGYRVLedSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFCT 82
Cdd:PRK09468    8 ILVVDDDMRLRALLERYLTE-QGFQVR--SAANAEQMDRLLTRESFHLMVLDLMLPGEDGLSICRRLRSQNNPTPIIMLT 84

                          90       100
                  ....*....|....*....|...
gi 1499078941  83 AHDEFA--LEAFQVSAVGYLVKP 103
Cdd:PRK09468   85 AKGEEVdrIVGLEIGADDYLPKP 107
REC_PFxFATGY cd17586
phosphoacceptor receiver (REC) domain of PFxFATGY motif single-domain (stand-alone) response ...
 3-116 4.52e-07

phosphoacceptor receiver (REC) domain of PFxFATGY motif single-domain (stand-alone) response regulators; This subfamily is composed of stand-alone response regulators (RRs) containing the PFxFATG[G/Y] motif; RRs with such a motif are also called ''FAT GUY'' response regulators. Included in this subfamily are Sphingomonas melonis SdrG, Sinorhizobium meliloti Sma0114, and Erythrobacter litoralis EL_LovR. SdrG is involved in the control of the general stress response. Sma0114 is part of the Sma0113/Sma0114 two-component system (TCS) that is involved in catabolite repression and polyhydroxy butyrate synthesis. EL_LovR is involved in a light-regulated TCS. PFxFATG[G/Y] RRs are typically associated with histidine-tryptophan-glutamate (HWE) histidine kinases that constitute a subclass of the larger histidine kinase superfamily characterized by an altered ATP binding site, which lacks the F-box that is normally an integral component of the ATP lid. The PFxFATG[G/Y] motif is involved in conformational changes after phosphorylation that results in the activation of the RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381122 [Multi-domain]  Cd Length: 111  Bit Score: 47.08  E-value: 4.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVNEIEGYRVLedSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPpaVVFCT 82
Cdd:cd17586     1 VLVLEDEPLIAMNLEDALEDLGGKEVV--TAATCAEALRSLADGPIDIAILDVNLGGETSIPVADALKRRAIP--FIFAT 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1499078941  83 AHDEFALEAFQVSAVGYLVKPVRAEHLIEALKKA 116
Cdd:cd17586    77 GYGDSHGIDSRLIDVPVLRKPFDADSALAALAML 110
PRK10529 PRK10529
DNA-binding transcriptional activator KdpE; Provisional
 2-118 4.53e-07

DNA-binding transcriptional activator KdpE; Provisional


Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 49.03  E-value: 4.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   2 NVLIVDDEPLAReRLSRMVNEIEGYRVLEdsASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFC 81
Cdd:PRK10529    3 NVLIVEDEQAIR-RFLRTALEGDGMRVFE--AETLQRGLLEAATRKPDLIILDLGLPDGDGIEFIRDLRQWSAIPVIVLS 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1499078941  82 TAHDEF-ALEAFQVSAVGYLVKPVRAEHLIEALKKAER 118
Cdd:PRK10529   80 ARSEESdKIAALDAGADDYLSKPFGIGELQARLRVALR 117
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
1-74 4.74e-07

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 50.50  E-value: 4.74e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1499078941    1 MNVLIVDDEPLARERLSRMVNEIeGYRVleDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREA 74
Cdd:PRK09959   959 LSILIADDHPTNRLLLKRQLNLL-GYDV--DEATDGVQALHKVSMQHYDLLITDVNMPNMDGFELTRKLREQNS 1029
PRK10643 PRK10643
two-component system response regulator PmrA;
1-103 5.62e-07

two-component system response regulator PmrA;


Pssm-ID: 182612 [Multi-domain]  Cd Length: 222  Bit Score: 48.88  E-value: 5.62e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEPLARERLSrMVNEIEGYRVleDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVF 80
Cdd:PRK10643    1 MKILIVEDDTLLLQGLI-LALQTEGYAC--DCASTAREAEALLESGHYSLVVLDLGLPDEDGLHLLRRWRQKKYTLPVLI 77

                          90       100
                  ....*....|....*....|....*..
gi 1499078941  81 CTAHDefALE----AFQVSAVGYLVKP 103
Cdd:PRK10643   78 LTARD--TLEdrvaGLDVGADDYLVKP 102
REC_PatA-like cd17602
phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) ...
 3-103 5.96e-07

phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) PatA is necessary for proper patterning of heterocysts along filaments. PatA contains phosphoacceptor REC domain at its C-terminus and an N-terminal PATAN (PatA N-terminus) domain, which was proposed in a bioinformatics study to mediate protein-protein interactions. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members of this group may have an inactive REC domain, lacking canonical metal-binding and active site residues.


Pssm-ID: 381129 [Multi-domain]  Cd Length: 102  Bit Score: 46.59  E-value: 5.96e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLarerLSRMVNEI---EGYRV--LEDSASngeeALALIEKHKPDVVLLDIRMPGIDGLQVaAKLCE-----R 72
Cdd:cd17602     1 VACVDDRPS----IQKMIEYFlekQGFRVvvIDDPLR----ALTTLLNSKPDLILIDIDMPDLDGYEL-CSLLRkssalK 71

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1499078941  73 EAPpaVVFCTAHDEFA--LEAFQVSAVGYLVKP 103
Cdd:cd17602    72 DTP--IIMLTGKDGLVdrIRAKMAGASGYLTKP 102
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
 1-103 6.26e-07

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 48.80  E-value: 6.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEPLARERLSRMVnEIEGYRVleDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVF 80
Cdd:PRK11083    4 PTILLVEDEQAIADTLVYAL-QSEGFTV--EWFERGLPALDKLRQQPPDLVILDVGLPDISGFELCRQLLAFHPALPVIF 80

                          90       100
                  ....*....|....*....|....*...
gi 1499078941  81 CTA-HDEF----ALEafqVSAVGYLVKP 103
Cdd:PRK11083   81 LTArSDEVdrlvGLE---IGADDYVAKP 105
REC_OmpR_CtrA cd17616
phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is ...
 3-110 8.04e-07

phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is part of the CckA-ChpT-CtrA phosphorelay that is conserved in alphaproteobacteria and is important in orchestrating the cell cycle, polar development, and flagellar biogenesis. CtrA is the master regulator of flagella synthesis genes and also regulates genes involved in the cell cycle, exopolysaccharide synthesis, and cyclic-di-GMP signaling. CtrA is active as a transcription factor when phosphorylated. It is a member of the OmpR family of DNA-binding response regulators, characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381132 [Multi-domain]  Cd Length: 114  Bit Score: 46.63  E-value: 8.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVNEiEGYRVleDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFCT 82
Cdd:cd17616     1 VLLIEDDSATAQSIELMLKS-EGFNV--YTTDLGEEGLDLGKLYDYDIILLDLNLPDMSGYEVLRTLRLAKVKTPILILS 77

                          90       100       110
                  ....*....|....*....|....*....|
gi 1499078941  83 AHDEF--ALEAFQVSAVGYLVKPVRAEHLI 110
Cdd:cd17616    78 GLADIedKVKGLGFGADDYMTKPFHKDELV 107
REC_GlnL-like cd17565
phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar ...
 5-69 1.49e-06

phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar proteins; Bacillus subtilis GlnL is part of the GlnK-GlnL (formerly YcbA-YcbB) two-component system that positively regulates the expression of the glsA-glnT (formerly ybgJ-ybgH) operon in response to glutamine. It contains a REC domain and a DNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381112 [Multi-domain]  Cd Length: 103  Bit Score: 45.73  E-value: 1.49e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1499078941   5 IVDDEPLARERLSRMVNEIEGYRVLeDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKL 69
Cdd:cd17565     3 IVDDDKNIIKILSDIIEDDDLGEVV-GEADNGAQAYDEILFLQPDIVLIDLLMPGMDGIQLVRKL 66
PRK13435 PRK13435
response regulator; Provisional
 1-117 1.54e-06

response regulator; Provisional


Pssm-ID: 184052 [Multi-domain]  Cd Length: 145  Bit Score: 46.58  E-value: 1.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEPLARERLSRMVNEIeGYRVLeDSASNGEEALALIEKHKPDVVLLDIR-MPGIDGLQVAAKLcEREAPPAVV 79
Cdd:PRK13435    6 LKVLIVEDEALIALELEKLVEEA-GHEVV-GIAMSSEQAIALGRRRQPDVALVDVHlADGPTGVEVARRL-SADGGVEVV 82

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1499078941  80 FCTAHDEFALEAFqVSAVGYLVKPVRAEHLIEALKKAE 117
Cdd:PRK13435   83 FMTGNPERVPHDF-AGALGVIAKPYSPRGVARALSYLS 119
PRK10360 PRK10360
transcriptional regulator UhpA;
1-116 3.22e-06

transcriptional regulator UhpA;


Pssm-ID: 182408 [Multi-domain]  Cd Length: 196  Bit Score: 46.51  E-value: 3.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEPLARERLSRMVNEIEGYRVLEDSASnGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLcerEAPPAVVF 80
Cdd:PRK10360    2 ITVALIDDHLIVRSGFAQLLGLEPDLQVVAEFGS-GREALAGLPGRGVQVCICDISMPDISGLELLSQL---PKGMATIM 77

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1499078941  81 CTAHDEFAL--EAFQVSAVGYLVKPVRAEHLIEALKKA 116
Cdd:PRK10360   78 LSVHDSPALveQALNAGARGFLSKRCSPDELIAAVHTV 115
PRK10693 PRK10693
two-component system response regulator RssB;
33-105 4.50e-06

two-component system response regulator RssB;


Pssm-ID: 182652 [Multi-domain]  Cd Length: 303  Bit Score: 46.91  E-value: 4.50e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1499078941  33 ASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCER--EAPPAVVFCTAHDEFALEAFQVSAVGYLVKPVR 105
Cdd:PRK10693    3 AANGVDALELLGGFTPDLIICDLAMPRMNGIEFVEHLRNRgdQTPVLVISATENMADIAKALRLGVQDVLLKPVK 77
PRK10710 PRK10710
DNA-binding transcriptional regulator BaeR; Provisional
 3-103 4.53e-06

DNA-binding transcriptional regulator BaeR; Provisional


Pssm-ID: 182665 [Multi-domain]  Cd Length: 240  Bit Score: 46.22  E-value: 4.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPlareRLSR-MVNEIE--GYRVleDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKL-CEREAPpaV 78
Cdd:PRK10710   13 ILIVEDEP----KLGQlLIDYLQaaSYAT--TLLSHGDEVLPYVRQTPPDLILLDLMLPGTDGLTLCREIrRFSDIP--I 84

                          90       100
                  ....*....|....*....|....*..
gi 1499078941  79 VFCTAHDEFA--LEAFQVSAVGYLVKP 103
Cdd:PRK10710   85 VMVTAKIEEIdrLLGLEIGADDYICKP 111
REC_ETR-like cd19933
phosphoacceptor receiver (REC) domain of plant ethylene receptors ETR1, ETR2, and EIN4, and ...
 3-104 5.86e-06

phosphoacceptor receiver (REC) domain of plant ethylene receptors ETR1, ETR2, and EIN4, and similar proteins; Plant ethylene receptors contain N-terminal transmembrane domains that contain an ethylene binding site and also serve in localization of the receptor to the endoplasmic reticulum or the Golgi apparatus and a C-terminal histidine kinase (HK)-like domain. There are five ethylene receptors (ETR1, ERS1, ETR2, ERS2, and EIN4) in Arabidopsis thaliana. ETR1, ETR2, and EIN4 also contain REC domains C-terminal to the HK domain. ETR1 and ERS1 belong to subfamily 1, and have functional HK domains while ETR2, ERS2, and EIN4 belong to subfamily 2, and lack the necessary residues for HK activity and may function as serine/threonine kinases. The plant hormone ethylene plays an important role in plant growth and development. It regulates seed germination, seedling growth, leaf and petal abscission, fruit ripening, organ senescence, and pathogen responses. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381160 [Multi-domain]  Cd Length: 117  Bit Score: 44.31  E-value: 5.86e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVNEIeGYRVleDSASNGEEALALI--EKHKPDVVLLDIRMPGIDGLQVAA---KLCEREAPPA 77
Cdd:cd19933     3 VLLVDDNAVNRMVTKGLLEKL-GCEV--TTVSSGEECLNLLasAEHSFQLVLLDLCMPEMDGFEVALrirKLFGRRERPL 79

                          90       100
                  ....*....|....*....|....*....
gi 1499078941  78 VVFCTAHDEFALEA--FQVSAVGYLVKPV 104
Cdd:cd19933    80 IVALTANTDDSTREkcLSLGMNGVITKPV 108
REC_OmpR_NsrR-like cd18159
phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family ...
 3-116 8.30e-06

phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family response regulators; Streptococcus agalactiae NsrR is a lantibiotic resistance-associated response regulator and is part of the nisin resistance operon. It is a member of the NsrRK two-component system (TCS) that is involved in the regulation of lantibiotic resistance genes such as a membrane-associated lipoprotein of LanI, and the nsr gene cluster which encodes for the resistance protein NSR and the ABC transporter NsrFP, both conferring resistance against nisin. This subfamily also includes Staphylococcus epidermidis GraR, part of the GraR/GraS TCS involved in resistance against cationic antimicrobial peptides, and Bacillus subtilis BceR, part of the BceS/BceR TCS involved in the regulation of bacitracin resistance. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381143 [Multi-domain]  Cd Length: 113  Bit Score: 43.81  E-value: 8.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIV-DDEPLARErLSRMVNEiEGYRVLedSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPaVVFC 81
Cdd:cd18159     1 ILIVeDDETIASL-LKKHLEK-WGYEVV--LIEDFEDVLEEFLQFKPDLVLLDINLPYFDGFYWCREIRQISNVP-IIFI 75

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1499078941  82 TAHDEFA--LEAFQVSAVGYLVKPVRAEHLIEALKKA 116
Cdd:cd18159    76 SSRDDNMdqVMAINMGGDDYITKPFDLDVLLAKIKAI 112
REC_OmpR_BaeR-like cd19938
phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is ...
 3-103 1.39e-05

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381165 [Multi-domain]  Cd Length: 114  Bit Score: 43.14  E-value: 1.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEP----LARERLSRmvneiEGYRVleDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAV 78
Cdd:cd19938     2 ILIVEDEPklaqLLIDYLRA-----AGYAP--TLLAHGDQVLPYVRHTPPDLILLDLMLPGTDGLTLCREIRRFSDVPII 74

                          90       100
                  ....*....|....*....|....*.
gi 1499078941  79 VFCTAHDEF-ALEAFQVSAVGYLVKP 103
Cdd:cd19938    75 MVTARVEEIdRLLGLELGADDYICKP 100
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
3-118 3.36e-05

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 43.94  E-value: 3.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSrMVNEIEGYRVLEdsASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKL----CEREAPPAV 78
Cdd:PRK10161    5 ILVVEDEAPIREMVC-FVLEQNGFQPVE--AEDYDSAVNQLNEPWPDLILLDWMLPGGSGIQFIKHLkresMTRDIPVVM 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1499078941  79 VFCTAHDEFALEAFQVSAVGYLVKPVRAEHLIEALKKAER 118
Cdd:PRK10161   82 LTARGEEEDRVRGLETGADDYITKPFSPKELVARIKAVMR 121
psREC_PRR cd17582
pseudo receiver domain of pseudo-response regulators; In Arabidopsis, five pseudo-response ...
 3-103 7.62e-05

pseudo receiver domain of pseudo-response regulators; In Arabidopsis, five pseudo-response regulators (PRRs), also called APRRs, comprise a core group of clock components that controls the pace of the central oscillator of the circadian clock, an endogenous time-keeping mechanism that enables organisms to adapt to external daily cycles. The coordinated sequential expression of PRR9 (APRR9), PRR7 (APRR7), PRR5 (APRR5), PRR3 (APRR3), and PRR1 (APRR1) results in circadian waves that may be at the basis of the endogenous circadian clock. PRRs contain an N-terminal pseudo receiver (psREC) domain that resembles the receiver domain of a two-component response regulator, but lacks an aspartate residue that accepts a phosphoryl group from the sensor kinase, and a CCT motif at the C-terminus that contains a putative nuclear localization signal. The psREC domain is involved in protein-protein interactions.


Pssm-ID: 381120 [Multi-domain]  Cd Length: 104  Bit Score: 40.85  E-value: 7.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVNEIeGYRVLEdsASNGEEALALIEKHKP--DVVLLDIRMPGIDGLQVAAKLCEREA----Pp 76
Cdd:cd17582     1 VLLVENDDSTRQIVTALLRKC-SYEVTA--ASDGLQAWDVLEDEQNeiDLILTEVDLPVSSGFKLLSYIMRHKIckniP- 76

                          90       100
                  ....*....|....*....|....*....
gi 1499078941  77 aVVFCTAHDEFAL--EAFQVSAVGYLVKP 103
Cdd:cd17582    77 -VIMMSSQDSVGVvfKCLSKGAADYLVKP 104
PRK10701 PRK10701
DNA-binding transcriptional regulator RstA; Provisional
 36-78 8.29e-05

DNA-binding transcriptional regulator RstA; Provisional


Pssm-ID: 236738 [Multi-domain]  Cd Length: 240  Bit Score: 42.70  E-value: 8.29e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1499078941  36 GEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAV 78
Cdd:PRK10701   34 GDRAEATILREQPDLVLLDIMLPGKDGMTICRDLRPKWQGPIV 76
PRK15479 PRK15479
transcriptional regulator TctD;
1-109 8.88e-05

transcriptional regulator TctD;


Pssm-ID: 185376 [Multi-domain]  Cd Length: 221  Bit Score: 42.40  E-value: 8.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEPLARERLSRMVNEiEGYRVleDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVF 80
Cdd:PRK15479    1 MRLLLAEDNRELAHWLEKALVQ-NGFAV--DCVFDGLAADHLLQSEMYALAVLDINMPGMDGLEVLQRLRKRGQTLPVLL 77

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1499078941  81 CTAHDEFA--LEAFQVSAVGYLVKPVRAEHL 109
Cdd:PRK15479   78 LTARSAVAdrVKGLNVGADDYLPKPFELEEL 108
REC_RitR-like cd19922
receiver (REC) domain of orphan response regulator RitR and similar domains; Streptococcus ...
 24-111 9.28e-05

receiver (REC) domain of orphan response regulator RitR and similar domains; Streptococcus pneumoniae RitR (Repressor of iron transport Regulator, formerly RR489) is an orphan two-component signal transduction response regulator that is required for lung pathogenicity. It acts to repress iron uptake via binding the pneumococcal iron uptake (Piu) transporter promoter. Members of this subfamily contain REC and DNA-binding output domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. However, members of this family do not contain the phosphorylatable aspartic acid residue and are phosphorylation-independent.


Pssm-ID: 381149 [Multi-domain]  Cd Length: 110  Bit Score: 40.54  E-value: 9.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941  24 EGYRVleDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLcEREAPPAVVFCTAHDEFA---LEAFQVSAVGYL 100
Cdd:cd19922    21 EGYRV--DLVETGQEALSLALETDYDLILLNVNLSDMSAQDFAEKL-SRIKPASVIIVLDHWEDLqeeLEEVQRFAVSYV 97

                          90
                  ....*....|.
gi 1499078941 101 VKPVRAEHLIE 111
Cdd:cd19922    98 VKPVLISNLVD 108
PRK10955 PRK10955
envelope stress response regulator transcription factor CpxR;
1-114 1.69e-04

envelope stress response regulator transcription factor CpxR;


Pssm-ID: 182864 [Multi-domain]  Cd Length: 232  Bit Score: 41.71  E-value: 1.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MN-VLIVDDEplaRERLS--RMVNEIEGYRVLedSASNGEEALALIEKhKPDVVLLDIRMPGIDGLQVAAKLCEREAPPA 77
Cdd:PRK10955    1 MNkILLVDDD---RELTSllKELLEMEGFNVI--VAHDGEQALDLLDD-SIDLLLLDVMMPKKNGIDTLKELRQTHQTPV 74

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1499078941  78 VVFCTAHDEF-ALEAFQVSAVGYLVKPVRAEHLIEALK 114
Cdd:PRK10955   75 IMLTARGSELdRVLGLELGADDYLPKPFNDRELVARIR 112
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
 3-115 3.05e-04

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 39.35  E-value: 3.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   3 VLIVDDEPLARERLSRMVNEiEGYRVLEdSASNGEEALALIEKhKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFCT 82
Cdd:cd17594     2 VLVVDDDAAMRHLLILYLRE-RGFDVTA-AADGAEEARLMLHR-RVDLVLLDLRLGQESGLDLLRTIRARSDVPIIIISG 78

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1499078941  83 AHDEFA--LEAFQVSAVGYLVKPVRAEHLIEALKK 115
Cdd:cd17594    79 DRRDEIdrVVGLELGADDYLAKPFGLRELLARVRA 113
PRK10336 PRK10336
two-component system response regulator QseB;
1-117 4.89e-04

two-component system response regulator QseB;


Pssm-ID: 182387 [Multi-domain]  Cd Length: 219  Bit Score: 40.26  E-value: 4.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEPLA----RERLSRMvneieGYRVleDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPP 76
Cdd:PRK10336    1 MRILLIEDDMLIgdgiKTGLSKM-----GFSV--DWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQRE 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1499078941  77 AVVFCTAHDEFA--LEAFQVSAVGYLVKPVRaehLIEALKKAE 117
Cdd:PRK10336   74 PVLILTARDALAerVEGLRLGADDYLCKPFA---LIEVAARLE 113
PRK09836 PRK09836
DNA-binding transcriptional activator CusR; Provisional
 1-103 1.39e-03

DNA-binding transcriptional activator CusR; Provisional


Pssm-ID: 182102 [Multi-domain]  Cd Length: 227  Bit Score: 38.75  E-value: 1.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   1 MNVLIVDDEPLARERLSRMVNEiEGYRVleDSASNGEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVF 80
Cdd:PRK09836    1 MKLLIVEDEKKTGEYLTKGLTE-AGFVV--DLADNGLNGYHLAMTGDYDLIILDIMLPDVNGWDIVRMLRSANKGMPILL 77

                          90       100
                  ....*....|....*....|....*
gi 1499078941  81 CTAHD--EFALEAFQVSAVGYLVKP 103
Cdd:PRK09836   78 LTALGtiEHRVKGLELGADDYLVKP 102
PRK09935 PRK09935
fimbriae biosynthesis transcriptional regulator FimZ;
2-102 1.59e-03

fimbriae biosynthesis transcriptional regulator FimZ;


Pssm-ID: 182154 [Multi-domain]  Cd Length: 210  Bit Score: 38.70  E-value: 1.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499078941   2 NVLIVDDEPLARERLSRMVNEIEGYRVLEDSASNgEEALALIEKHKPDVVLLDIRMPGIDGLQVAAKLCEREAPPAVVFC 81
Cdd:PRK09935    5 SVIIMDTHPIIRMSIEVLLQKNSELQIVLKTDDY-RITIDYLRTRPVDLIIMDIDLPGTDGFTFLKRIKQIQSTVKVLFL 83

                          90       100
                  ....*....|....*....|...
gi 1499078941  82 TAHDE--FALEAFQVSAVGYLVK 102
Cdd:PRK09935   84 SSKSEcfYAGRAIQAGANGFVSK 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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