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Conserved domains on  [gi|1498198625|gb|RMG53621|]
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ArsR family transcriptional regulator [Chloroflexi bacterium]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 10-88 3.96e-45

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


:

Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 140.24  E-value: 3.96e-45
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1498198625  10 TLQALSDPTRRAIIRMLNERDMTAGEIAAHFAISAPSVSHHLNVLKTADLVTAERQGQRIVYRVNATVLQEMLSSLLDL 88
Cdd:NF033789    1 TFKALSDPTRREILELLKEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSLNTTVFEEVLGWLLDL 79
 
Name Accession Description Interval E-value
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 10-88 3.96e-45

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 140.24  E-value: 3.96e-45
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1498198625  10 TLQALSDPTRRAIIRMLNERDMTAGEIAAHFAISAPSVSHHLNVLKTADLVTAERQGQRIVYRVNATVLQEMLSSLLDL 88
Cdd:NF033789    1 TFKALSDPTRREILELLKEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSLNTTVFEEVLGWLLDL 79
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
2-89 2.94e-27

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 95.34  E-value: 2.94e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1498198625   2 SMEQSITRTLQALSDPTRRAIIRMLNERDMTAGEIAAHFAISAPSVSHHLNVLKTADLVTAERQGQRIVYRVNATVLQEM 81
Cdd:COG0640     5 KELEELAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAEL 84


                  ....*...
gi 1498198625  82 LSSLLDLL 89
Cdd:COG0640    85 LEWLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 9-82 2.01e-24

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 87.52  E-value: 2.01e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1498198625   9 RTLQALSDPTRRAIIRMLNERDMTAGEIAAHFAISAPSVSHHLNVLKTADLVTAERQGQRIVYRVNATVLQEML 82
Cdd:NF033788    3 ELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 11-87 7.25e-20

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 76.18  E-value: 7.25e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1498198625  11 LQALSDPTRRAIIRMLNERDMTAGEIAAHFAISAPSVSHHLNVLKTADLVTAERQGQRIVYRVNAT-VLQEMLSSLLD 87
Cdd:cd00090     1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDAeRLLALLESLLE 78
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
22-86 5.94e-17

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 68.39  E-value: 5.94e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1498198625   22 IIRMLNERDMTAGEIAAHFAISAPSVSHHLNVLKTADLVTAERQGQRIVYRVNATVLQEMLSSLL 86
Cdd:smart00418   2 ILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEELL 66
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 16-60 4.60e-13

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 57.84  E-value: 4.60e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1498198625  16 DPTRRAIIRMLNERDMTAGEIAAHFAISAPSVSHHLNVLKTADLV 60
Cdd:pfam01022   1 DPTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 1-73 1.09e-05

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 40.95  E-value: 1.09e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1498198625   1 MSMEQSItRTLQALSDPTRRAIIRMLNER-DMTAGEIAAHFAISAPSVSHHLNVLKTADLVTAERQGQRIVYRV 73
Cdd:PRK10141    1 MSFLLPL-QLFKILSDETRLGIVLLLRESgELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRL 73
 
Name Accession Description Interval E-value
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 10-88 3.96e-45

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 140.24  E-value: 3.96e-45
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1498198625  10 TLQALSDPTRRAIIRMLNERDMTAGEIAAHFAISAPSVSHHLNVLKTADLVTAERQGQRIVYRVNATVLQEMLSSLLDL 88
Cdd:NF033789    1 TFKALSDPTRREILELLKEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSLNTTVFEEVLGWLLDL 79
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
2-89 2.94e-27

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 95.34  E-value: 2.94e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1498198625   2 SMEQSITRTLQALSDPTRRAIIRMLNERDMTAGEIAAHFAISAPSVSHHLNVLKTADLVTAERQGQRIVYRVNATVLQEM 81
Cdd:COG0640     5 KELEELAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAEL 84


                  ....*...
gi 1498198625  82 LSSLLDLL 89
Cdd:COG0640    85 LEWLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 9-82 2.01e-24

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 87.52  E-value: 2.01e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1498198625   9 RTLQALSDPTRRAIIRMLNERDMTAGEIAAHFAISAPSVSHHLNVLKTADLVTAERQGQRIVYRVNATVLQEML 82
Cdd:NF033788    3 ELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 11-87 7.25e-20

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 76.18  E-value: 7.25e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1498198625  11 LQALSDPTRRAIIRMLNERDMTAGEIAAHFAISAPSVSHHLNVLKTADLVTAERQGQRIVYRVNAT-VLQEMLSSLLD 87
Cdd:cd00090     1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDAeRLLALLESLLE 78
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
22-86 5.94e-17

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 68.39  E-value: 5.94e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1498198625   22 IIRMLNERDMTAGEIAAHFAISAPSVSHHLNVLKTADLVTAERQGQRIVYRVNATVLQEMLSSLL 86
Cdd:smart00418   2 ILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEELL 66
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
1-83 5.70e-16

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 67.37  E-value: 5.70e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1498198625   1 MSMEQSITRTLQALSDPTRRAIIRMLNERDMTAGEIAAHFAISAPSVSHHLNVLKTADLVTAERQGQ-----RIVYRVNA 75
Cdd:COG1777     1 MSDDEDLDRLLDALGNPTRRRILALLSEEPAYVSELARELGVSRQAVYKHLRKLEEAGLVESYREGRedgraRKYYRLSA 80


                  ....*...
gi 1498198625  76 TVLQEMLS 83
Cdd:COG1777    81 FRLEVTLT 88
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 16-60 4.60e-13

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 57.84  E-value: 4.60e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1498198625  16 DPTRRAIIRMLNERDMTAGEIAAHFAISAPSVSHHLNVLKTADLV 60
Cdd:pfam01022   1 DPTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 9-67 1.26e-12

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 57.16  E-value: 1.26e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1498198625   9 RTLQALSDPTRRAIIRMLNERD-MTAGEIAAHFAISAPSVSHHLNVLKTADLVTAERQGQ 67
Cdd:pfam12840   2 DVAEALADPTRLRILRALVGDEpLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
6-72 1.30e-12

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 58.43  E-value: 1.30e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1498198625   6 SITRTLQALSDPTRRAIIRMLNERDMTAGEIAAHFAISAPSVSHHLNVLKTADLVTAERQG-----QRIVYR 72
Cdd:COG4189     8 ESLEVLKALASETRLRILRLLAEEPLNVNELAEALGLPKSTVSYHIRKLEEAGLIRTEYKPgkrgrQKICYL 79
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
9-74 2.34e-11

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 56.43  E-value: 2.34e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1498198625   9 RTLQALSDPTRRAIIRML-NERDMTAGEIAAHFAISAPSVSHHLNVLKTADLVTAERQGQRIVYRVN 74
Cdd:COG3398    89 KILAYLRRETPRRILLYLlENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYLN 155
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
6-73 9.34e-08

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 47.61  E-value: 9.34e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1498198625   6 SITRTLQALSDPTRRAIIRMLNERD-MTAGEIAAHFAISAPSVSHHLNVLKTADLVTAERQGQ-----RIVYRV 73
Cdd:COG2345     2 TDTPALAALADPTRRRILELLKRAGpVTAAELAEALGLTPNAVRRHLDALEEEGLVERETERRgrgrpAKLYRL 75
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 1-73 1.09e-05

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 40.95  E-value: 1.09e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1498198625   1 MSMEQSItRTLQALSDPTRRAIIRMLNER-DMTAGEIAAHFAISAPSVSHHLNVLKTADLVTAERQGQRIVYRV 73
Cdd:PRK10141    1 MSFLLPL-QLFKILSDETRLGIVLLLRESgELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRL 73
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
2-61 6.72e-04

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 36.80  E-value: 6.72e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1498198625   2 SMEQSITRTLqALSDpTRRAIIRMLNERDMTAGEIAAHFAISAPSVSHHLNVLKTADLVT 61
Cdd:COG4742     3 SMKLDLLDFL-FLSE-KRKNILLLLAEGPKTRSELAESLDVSRSTILRQLKELEERGLIE 60
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 14-64 2.94e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 33.33  E-value: 2.94e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1498198625  14 LSDPTRRAIIRMLNERDMTAGEIAAHFAISAPSVSHHLNVLKTADLVTAER 64
Cdd:pfam12802   3 LTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREP 53
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 20-73 9.01e-03

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 32.58  E-value: 9.01e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1498198625  20 RAIIRMLNERD--MTAGEIAAHFAISAPSVSHHLNVLKTADLVTAERQGQRIVYRV 73
Cdd:COG2512    18 RRVLELLRENGgrMTQSEIVKETGWSKSKVSRLLSRLEERGLIEKERVGRENVVEL 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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