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Conserved domains on  [gi|1495933541|ref|XP_026719108|]
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ras-related GTP-binding protein C isoform X1 [Athene cunicularia]

Protein Classification

GTR/RAG family Ras-related GTP-binding protein( domain architecture ID 10183657)

GTR/RAG family Ras-related GTP-binding protein similar to Homo sapiens RagC, a GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions

CATH:  3.40.50.300
EC:  3.6.5.-
Gene Ontology:  GO:0005525|GO:0003924
PubMed:  11073942|16732272|28788436
SCOP:  4005007

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RagC_like cd11385
Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins C and ...
 1-171 1.94e-120

Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins C and D; RagC and RagD are closely related Rag GTPases (ras-related GTP-binding protein C and D) that constitute a unique subgroup of the Ras superfamily, and are functional homologs of Saccharomyces cerevisiae Gtr2. These domains form heterodimers with RagA or RagB, and similarly, Gtr2 dimerizes with Gtr1 in order to function. They play an essential role in regulating amino acid-induced target of rapamycin complex 1 (TORC1) kinase signaling, exocytic cargo sorting at endosomes, and epigenetic control of gene expression. In response to amino acids, the Rag GTPases guide the TORC1 complex to activate the platform containing Rheb proto-oncogene by driving the relocalization of mTORC1 from discrete locations in the cytoplasm to a late endosomal and/or lysosomal compartment that is Rheb-enriched and contains Rab-7.


:

Pssm-ID: 206745 [Multi-domain]  Cd Length: 175  Bit Score: 343.82  E-value: 1.94e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495933541   1 MGLRRSGKSSIQKVVFHKMSPNETLFLESTNKIYKDDISNSSFVNFQIWDFPGQMDFFDPTFDYEMIFRGTGALIYVIDA 80
Cdd:cd11385     5 MGLRRSGKSSIQKVVFHKMSPNETLFLESTNKITKDDISNSSFVNFQIWDFPGQLDPFDPTLDPEMIFSGCGALVFVIDA 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495933541  81 QDDYMEALTRLHITVSKAYKVNPEMNFEVFIHKVDGLSDDHKIETQRDIHQRANDDLTDAGLEKLHLSFYLTSIYDHSIF 160
Cdd:cd11385    85 QDDYDEAIARLVETVTKAYKVNPNINFEVFIHKVDGLSEDHKIETQRDIQQRVTDELADAGLEDVQISFYLTSIYDHSIF 164

                         170
                  ....*....|.
gi 1495933541 161 EAFSKVVQKLI 171
Cdd:cd11385   165 EAFSKVVQKLI 175
 
Name Accession Description Interval E-value
RagC_like cd11385
Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins C and ...
 1-171 1.94e-120

Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins C and D; RagC and RagD are closely related Rag GTPases (ras-related GTP-binding protein C and D) that constitute a unique subgroup of the Ras superfamily, and are functional homologs of Saccharomyces cerevisiae Gtr2. These domains form heterodimers with RagA or RagB, and similarly, Gtr2 dimerizes with Gtr1 in order to function. They play an essential role in regulating amino acid-induced target of rapamycin complex 1 (TORC1) kinase signaling, exocytic cargo sorting at endosomes, and epigenetic control of gene expression. In response to amino acids, the Rag GTPases guide the TORC1 complex to activate the platform containing Rheb proto-oncogene by driving the relocalization of mTORC1 from discrete locations in the cytoplasm to a late endosomal and/or lysosomal compartment that is Rheb-enriched and contains Rab-7.


Pssm-ID: 206745 [Multi-domain]  Cd Length: 175  Bit Score: 343.82  E-value: 1.94e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495933541   1 MGLRRSGKSSIQKVVFHKMSPNETLFLESTNKIYKDDISNSSFVNFQIWDFPGQMDFFDPTFDYEMIFRGTGALIYVIDA 80
Cdd:cd11385     5 MGLRRSGKSSIQKVVFHKMSPNETLFLESTNKITKDDISNSSFVNFQIWDFPGQLDPFDPTLDPEMIFSGCGALVFVIDA 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495933541  81 QDDYMEALTRLHITVSKAYKVNPEMNFEVFIHKVDGLSDDHKIETQRDIHQRANDDLTDAGLEKLHLSFYLTSIYDHSIF 160
Cdd:cd11385    85 QDDYDEAIARLVETVTKAYKVNPNINFEVFIHKVDGLSEDHKIETQRDIQQRVTDELADAGLEDVQISFYLTSIYDHSIF 164

                         170
                  ....*....|.
gi 1495933541 161 EAFSKVVQKLI 171
Cdd:cd11385   165 EAFSKVVQKLI 175
Gtr1_RagA pfam04670
Gtr1/RagA G protein conserved region; GTR1 was first identified in S. cerevisiae as a ...
 1-223 1.93e-114

Gtr1/RagA G protein conserved region; GTR1 was first identified in S. cerevisiae as a suppressor of a mutation in RCC1. Biochemical analysis revealed that Gtr1 is in fact a G protein of the Ras family. The RagA/B proteins are the human homologs of Gtr1. Included in this family is the human Rag C, a novel protein that has been shown to interact with RagA/B.


Pssm-ID: 398377 [Multi-domain]  Cd Length: 231  Bit Score: 330.70  E-value: 1.93e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495933541   1 MGLRRSGKSSIQKVVFHKMSPNETLFLESTNKIYKDDISNSSFVNFQIWDFPGQMDFFDP--TFDYEMIFRGTGALIYVI 78
Cdd:pfam04670   5 MGLSGSGKSSMRSVIFSNYSPRDTLRLGATIDVEHSHVRFLGNLVLNLWDCGGQDDFFDNylTFQKEHIFSNVGVLIYVF 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495933541  79 DAQ-DDYMEALTRLHITVSKAYKVNPEMNFEVFIHKVDGLSDDHKIETQRDIHQRANDDLTDAGLEkLHLSFYLTSIYDH 157
Cdd:pfam04670  85 DVQsREYEEDLARLKETIEALYQYSPDAKVFVLIHKMDLIQEDHREEIFRDRKQEIREESEDLGLE-LDLSFFLTSIWDE 163

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1495933541 158 SIFEAFSKVVQKLIPQLPTLENLLNIFISNSGIEKAFLFDVVSKIYIATDSSP--VDMQSYELCCDMI 223
Cdd:pfam04670 164 SLYKAWSSIVQKLIPNLPTLENLLKVFCSNSDADEVFLFERTTFLVIATDSRSpvDDMQRYEKCSDII 231
Gem1 COG1100
GTPase SAR1 family domain [General function prediction only];
2-170 1.79e-06

GTPase SAR1 family domain [General function prediction only];


Pssm-ID: 440717 [Multi-domain]  Cd Length: 177  Bit Score: 47.67  E-value: 1.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495933541   2 GLRRSGKSS-IQKVVFHKMSPNETLfleSTN--KIYKDDIS-NSSFVNFQIWDFPGQMDFFDPTFDYEMIFRGTGALIYV 77
Cdd:COG1100    10 GTGGVGKTSlVNRLVGDIFSLEKYL---STNgvTIDKKELKlDGLDVDLVIWDTPGQDEFRETRQFYARQLTGASLYLFV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495933541  78 IDA-QDDYMEALTRLHITVSKAYKVNPEMnfeVFIHKVDgLSDDHKIETQrdihqranDDLTDAGLEKLHLSFYLTSIYD 156
Cdd:COG1100    87 VDGtREETLQSLYELLESLRRLGKKSPII---LVLNKID-LYDEEEIEDE--------ERLKEALSEDNIVEVVATSAKT 154

                         170
                  ....*....|....*
gi 1495933541 157 -HSIFEAFSKVVQKL 170
Cdd:COG1100   155 gEGVEELFAALAEIL 169
 
Name Accession Description Interval E-value
RagC_like cd11385
Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins C and ...
 1-171 1.94e-120

Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins C and D; RagC and RagD are closely related Rag GTPases (ras-related GTP-binding protein C and D) that constitute a unique subgroup of the Ras superfamily, and are functional homologs of Saccharomyces cerevisiae Gtr2. These domains form heterodimers with RagA or RagB, and similarly, Gtr2 dimerizes with Gtr1 in order to function. They play an essential role in regulating amino acid-induced target of rapamycin complex 1 (TORC1) kinase signaling, exocytic cargo sorting at endosomes, and epigenetic control of gene expression. In response to amino acids, the Rag GTPases guide the TORC1 complex to activate the platform containing Rheb proto-oncogene by driving the relocalization of mTORC1 from discrete locations in the cytoplasm to a late endosomal and/or lysosomal compartment that is Rheb-enriched and contains Rab-7.


Pssm-ID: 206745 [Multi-domain]  Cd Length: 175  Bit Score: 343.82  E-value: 1.94e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495933541   1 MGLRRSGKSSIQKVVFHKMSPNETLFLESTNKIYKDDISNSSFVNFQIWDFPGQMDFFDPTFDYEMIFRGTGALIYVIDA 80
Cdd:cd11385     5 MGLRRSGKSSIQKVVFHKMSPNETLFLESTNKITKDDISNSSFVNFQIWDFPGQLDPFDPTLDPEMIFSGCGALVFVIDA 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495933541  81 QDDYMEALTRLHITVSKAYKVNPEMNFEVFIHKVDGLSDDHKIETQRDIHQRANDDLTDAGLEKLHLSFYLTSIYDHSIF 160
Cdd:cd11385    85 QDDYDEAIARLVETVTKAYKVNPNINFEVFIHKVDGLSEDHKIETQRDIQQRVTDELADAGLEDVQISFYLTSIYDHSIF 164

                         170
                  ....*....|.
gi 1495933541 161 EAFSKVVQKLI 171
Cdd:cd11385   165 EAFSKVVQKLI 175
Gtr1_RagA pfam04670
Gtr1/RagA G protein conserved region; GTR1 was first identified in S. cerevisiae as a ...
 1-223 1.93e-114

Gtr1/RagA G protein conserved region; GTR1 was first identified in S. cerevisiae as a suppressor of a mutation in RCC1. Biochemical analysis revealed that Gtr1 is in fact a G protein of the Ras family. The RagA/B proteins are the human homologs of Gtr1. Included in this family is the human Rag C, a novel protein that has been shown to interact with RagA/B.


Pssm-ID: 398377 [Multi-domain]  Cd Length: 231  Bit Score: 330.70  E-value: 1.93e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495933541   1 MGLRRSGKSSIQKVVFHKMSPNETLFLESTNKIYKDDISNSSFVNFQIWDFPGQMDFFDP--TFDYEMIFRGTGALIYVI 78
Cdd:pfam04670   5 MGLSGSGKSSMRSVIFSNYSPRDTLRLGATIDVEHSHVRFLGNLVLNLWDCGGQDDFFDNylTFQKEHIFSNVGVLIYVF 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495933541  79 DAQ-DDYMEALTRLHITVSKAYKVNPEMNFEVFIHKVDGLSDDHKIETQRDIHQRANDDLTDAGLEkLHLSFYLTSIYDH 157
Cdd:pfam04670  85 DVQsREYEEDLARLKETIEALYQYSPDAKVFVLIHKMDLIQEDHREEIFRDRKQEIREESEDLGLE-LDLSFFLTSIWDE 163

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1495933541 158 SIFEAFSKVVQKLIPQLPTLENLLNIFISNSGIEKAFLFDVVSKIYIATDSSP--VDMQSYELCCDMI 223
Cdd:pfam04670 164 SLYKAWSSIVQKLIPNLPTLENLLKVFCSNSDADEVFLFERTTFLVIATDSRSpvDDMQRYEKCSDII 231
Rag cd09915
Rag GTPase subfamily of Ras-related GTPases; Rag GTPases (ras-related GTP-binding proteins) ...
 2-171 2.39e-97

Rag GTPase subfamily of Ras-related GTPases; Rag GTPases (ras-related GTP-binding proteins) constitute a unique subgroup of the Ras superfamily, playing an essential role in regulating amino acid-induced target of rapamycin complex 1 (TORC1) kinase signaling, exocytic cargo sorting at endosomes, and epigenetic control of gene expression. This subfamily consists of RagA and RagB as well as RagC and RagD that are closely related. Saccharomyces cerevisiae encodes single orthologs of metazoan RagA/B and RagC/D, Gtr1 and Gtr2, respectively. Dimer formation is important for their cellular function; these domains form heterodimers, as RagA or RagB dimerizes with RagC or RagD, and similarly, Gtr1 dimerizes with Gtr2. In response to amino acids, the Rag GTPases guide the TORC1 complex to activate the platform containing Rheb proto-oncogene by driving the relocalization of mTORC1 from discrete locations in the cytoplasm to a late endosomal and/or lysosomal compartment that is Rheb-enriched and contains Rab-7.


Pssm-ID: 206742 [Multi-domain]  Cd Length: 175  Bit Score: 285.23  E-value: 2.39e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495933541   2 GLRRSGKSSIQKVVFHKMSPNETLFLESTNKIYKDDISNSSFVNFQIWDFPGQMDFFDPTFDYEMIFRGTGALIYVIDAQ 81
Cdd:cd09915     6 GRRRSGKSSIRKVVFHNYSPFDTLRLESTIDVEHSHLSFLGN*TLNLWDCPGQDVFFEPTKDKEHIFQ*VGALIYVIDVQ 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495933541  82 DDYMEALTRLHITVSKAYKVNPEMNFEVFIHKVDGLSDDHKIETQRDIHQRANDDLTDAGLEKLHLSFYLTSIYDHSIFE 161
Cdd:cd09915    86 DEYLKAITILAKALKQAYKVNPDANIEVLIHKVDGLSLDKKEELQRDI*QRLSETLSEFGLEFPNLSFYLTSIWDHSIYE 165

                         170
                  ....*....|
gi 1495933541 162 AFSKVVQKLI 171
Cdd:cd09915   166 AFSQIVQKLI 175
RagA_like cd11384
Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and ...
 1-217 2.52e-16

Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B; RagA and RagB are closely related Rag GTPases (ras-related GTP-binding protein A and B) that constitute a unique subgroup of the Ras superfamily, and are functional homologs of Saccharomyces cerevisiae Gtr1. These domains function by forming heterodimers with RagC or RagD, and similarly, Gtr1 dimerizes with Gtr2, through the carboxy-terminal segments. They play an essential role in regulating amino acid-induced target of rapamycin complex 1 (TORC1) kinase signaling, exocytic cargo sorting at endosomes, and epigenetic control of gene expression. In response to amino acids, the Rag GTPases guide the TORC1 complex to activate the platform containing Rheb proto-oncogene by driving the relocalization of mTORC1 from discrete locations in the cytoplasm to a late endosomal and/or lysosomal compartment that is Rheb-enriched and contains Rab-7.


Pssm-ID: 206744  Cd Length: 286  Bit Score: 78.02  E-value: 2.52e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495933541   1 MGLRRSGKSSIQKVVFHKMSPNETLFLESTNKIykddisNSSFVNF------QIWDFPGQMDFFDPTFDY--EMIFRGTG 72
Cdd:cd11384     5 MGKSGSGKTSMRSIIFANYLARDTRRLGATIDV------EHSHVRFlgnlvlNLWDCGGQDAFMENYFTSqrDHIFRNVE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495933541  73 ALIYVIDAQDDYMEA-LTRLHITVSKAYKVNPEMNFEVFIHKVDGLSDDHK----IETQRDIHQRANDdltdaglekLHL 147
Cdd:cd11384    79 VLIYVFDVESRELEKdLTYFRSCLEALRQNSPDAKVFVLIHKMDLVQEDEReavfERKEKELRRLSEP---------LEV 149

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1495933541 148 SFYLTSIYDHSIFEAFSKVVQKLIPQLPTLENLLNIFISNSGIEKAFLFDVVSKIYIATDSSP----VDMQSYE 217
Cdd:cd11384   150 TCFPTSIWDETLYKAWSSIVYSLIPNIQVLESNLKKFADICEADEVVLFERATFLVISHSSRKeasaLDPHRFE 223
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
 1-168 5.12e-10

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 57.47  E-value: 5.12e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495933541   1 MGLRRSGKSSIQKVVFHKMSPNETLFLESTNKIYKDDISNSS-FVNFQIWDFPGQMDFFDPTF--DYEMIFRGTGALIYV 77
Cdd:cd00882     3 VGRGGVGKSSLLNALLGGEVGEVSDVPGTTRDPDVYVKELDKgKVKLVLVDTPGLDEFGGLGReeLARLLLRGADLILLV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495933541  78 IDAQDDYMEALTRLHItvsKAYKVNPEMNFEVFIHKVDGLSDDHKIETQRDIHQranddltdagLEKLHLSFYLTSIYDH 157
Cdd:cd00882    83 VDSTDRESEEDAKLLI---LRRLRKEGIPIILVGNKIDLLEEREVEELLRLEEL----------AKILGVPVFEVSAKTG 149

                         170
                  ....*....|..
gi 1495933541 158 S-IFEAFSKVVQ 168
Cdd:cd00882   150 EgVDELFEKLIE 161
Gem1 COG1100
GTPase SAR1 family domain [General function prediction only];
2-170 1.79e-06

GTPase SAR1 family domain [General function prediction only];


Pssm-ID: 440717 [Multi-domain]  Cd Length: 177  Bit Score: 47.67  E-value: 1.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495933541   2 GLRRSGKSS-IQKVVFHKMSPNETLfleSTN--KIYKDDIS-NSSFVNFQIWDFPGQMDFFDPTFDYEMIFRGTGALIYV 77
Cdd:COG1100    10 GTGGVGKTSlVNRLVGDIFSLEKYL---STNgvTIDKKELKlDGLDVDLVIWDTPGQDEFRETRQFYARQLTGASLYLFV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495933541  78 IDA-QDDYMEALTRLHITVSKAYKVNPEMnfeVFIHKVDgLSDDHKIETQrdihqranDDLTDAGLEKLHLSFYLTSIYD 156
Cdd:COG1100    87 VDGtREETLQSLYELLESLRRLGKKSPII---LVLNKID-LYDEEEIEDE--------ERLKEALSEDNIVEVVATSAKT 154

                         170
                  ....*....|....*
gi 1495933541 157 -HSIFEAFSKVVQKL 170
Cdd:COG1100   155 gEGVEELFAALAEIL 169
Arf_Arl cd00878
ADP-ribosylation factor(Arf)/Arf-like (Arl) small GTPases; Arf (ADP-ribosylation factor)/Arl ...
 2-92 2.19e-03

ADP-ribosylation factor(Arf)/Arf-like (Arl) small GTPases; Arf (ADP-ribosylation factor)/Arl (Arf-like) small GTPases. Arf proteins are activators of phospholipase D isoforms. Unlike Ras proteins they lack cysteine residues at their C-termini and therefore are unlikely to be prenylated. Arfs are N-terminally myristoylated. Members of the Arf family are regulators of vesicle formation in intracellular traffic that interact reversibly with membranes of the secretory and endocytic compartments in a GTP-dependent manner. They depart from other small GTP-binding proteins by a unique structural device, interswitch toggle, that implements front-back communication from N-terminus to the nucleotide binding site. Arf-like (Arl) proteins are close relatives of the Arf, but only Arl1 has been shown to function in membrane traffic like the Arf proteins. Arl2 has an unrelated function in the folding of native tubulin, and Arl4 may function in the nucleus. Most other Arf family proteins are so far relatively poorly characterized. Thus, despite their significant sequence homologies, Arf family proteins may regulate unrelated functions.


Pssm-ID: 206644 [Multi-domain]  Cd Length: 158  Bit Score: 38.33  E-value: 2.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495933541   2 GLRRSGKSSIqkvvFHKMSPNETLFLESTN--KIYKDDISNssfVNFQIWDFPGQMDFFDPTFDYemiFRGTGALIYVID 79
Cdd:cd00878     6 GLDGAGKTTI----LYKLKLGEVVTTIPTIgfNVETVEYKN---VKFTVWDVGGQDKIRPLWKHY---YENTDGLIFVVD 75

                          90
                  ....*....|....*
gi 1495933541  80 AQD--DYMEALTRLH 92
Cdd:cd00878    76 SSDreRIEEAKNELH 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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