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Conserved domains on  [gi|149589008|ref|NP_000276|]
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xaa-Pro dipeptidase isoform 1 [Homo sapiens]

Protein Classification

aminopeptidase P family protein( domain architecture ID 10659798)

aminopeptidase family protein P (peptidase M24) cleaves amido-, imido- or amidino-containing bonds, exhibiting a fairly narrow substrate specificity compared to other metallo-aminopeptidases, possibly playing roles in regulation of biological processes

CATH:  3.40.350.10|3.90.230.10
EC:  3.4.11.-
Gene Ontology:  GO:0004177|GO:0016020|GO:0070006|GO:0046872|GO:0006508
MEROPS:  M24
PubMed:  30066404|9434107|12475202

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
 192-467 3.69e-130

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


:

Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 377.30  E-value: 3.69e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 192 LEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSgeNSAVLHYGHagapNDRTIQNGD 271
Cdd:cd01087    1 IELMRKACDISAEAHRAAMKASRPGMSEYELEAEFEYEFRSRGARLAYSYIVAAGS--NAAILHYVH----NDQPLKDGD 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 272 MCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSV 351
Cdd:cd01087   75 LVLIDAGAEYGGYASDITRTFPVNGKFTDEQRELYEAVLAAQKAAIAACKPGVSYEDIHLLAHRVLAEGLKELGILKGDV 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 352 DAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYpegveridepgLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEaladpar 431
Cdd:cd01087  155 DEIVESGAYAKFFPHGLGHYLGLDVHDVGGY-----------LRYLRRARPLEPGMVITIEPGIYFIPDLLDV------- 216

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 149589008 432 asflnrevlQRFRGFGGVRIEEDVVVTDSGIELLTC 467
Cdd:cd01087  217 ---------PEYFRGGGIRIEDDVLVTEDGPENLTR 243
AMP_N smart01011
Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the ...
 18-155 3.05e-40

Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the creatinase N-terminal domain. However, little or no sequence similarity exists between the two families.


:

Pssm-ID: 198079  Cd Length: 135  Bit Score: 141.61  E-value: 3.05e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008    18 VPLALFALNRQRLCERLrknpavQAGSIVVLQGGEETQRYCtDTGVLFRQESFFHWAFGVTEPGCYGVIDV--DTGKSTL 95
Cdd:smart01011   1 IPAAEYAARRRRLAAKL------FPGSVAVLPAGPEKVRSN-DTDYPFRQDSDFYYLTGFDEPDAVLVLDPsgGGGKSTL 73

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 149589008    96 FVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTS--QKPSVLLTLRGVNTDSG 155
Cdd:smart01011  74 FVPPRDPEDELWDGPRLGLEEAKEKFGVDEVYPIDELDAVLPGllAGAGTVYYLLGRDPDLD 135
 
Name Accession Description Interval E-value
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
 192-467 3.69e-130

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 377.30  E-value: 3.69e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 192 LEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSgeNSAVLHYGHagapNDRTIQNGD 271
Cdd:cd01087    1 IELMRKACDISAEAHRAAMKASRPGMSEYELEAEFEYEFRSRGARLAYSYIVAAGS--NAAILHYVH----NDQPLKDGD 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 272 MCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSV 351
Cdd:cd01087   75 LVLIDAGAEYGGYASDITRTFPVNGKFTDEQRELYEAVLAAQKAAIAACKPGVSYEDIHLLAHRVLAEGLKELGILKGDV 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 352 DAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYpegveridepgLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEaladpar 431
Cdd:cd01087  155 DEIVESGAYAKFFPHGLGHYLGLDVHDVGGY-----------LRYLRRARPLEPGMVITIEPGIYFIPDLLDV------- 216

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 149589008 432 asflnrevlQRFRGFGGVRIEEDVVVTDSGIELLTC 467
Cdd:cd01087  217 ---------PEYFRGGGIRIEDDVLVTEDGPENLTR 243
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
178-475 2.17e-75

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 239.34  E-value: 2.17e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 178 PEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHsSYTCICGSGENSAVLHYG 257
Cdd:COG0006   65 DLLEELRAIKSPEEIELMRKAARIADAAHEAALAALRPGVTEREVAAELEAAMRRRGAEGP-SFDTIVASGENAAIPHYT 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 258 hagaPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPAnGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLAdrih 337
Cdd:COG0006  144 ----PTDRPLKPGDLVLIDAGAEYDGYTSDITRTVAV-GEPSDEQREIYEAVLEAQEAAIAALKPGVTGGEVDAAA---- 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 338 leelahmgilsgsVDAMVQAHLGAvFMPHGLGHFLGIDVHDVGGYPEGVERIdepglrslrtarhLQPGMVLTVEPGIYF 417
Cdd:COG0006  215 -------------RDVLAEAGYGE-YFPHGTGHGVGLDVHEGPQISPGNDRP-------------LEPGMVFTIEPGIYI 267

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 149589008 418 IdhlldealadparasflnrevlqrfrGFGGVRIEEDVVVTDSGIELLTCVPRTVEEI 475
Cdd:COG0006  268 P--------------------------GIGGVRIEDTVLVTEDGAEVLTRLPRELLEL 299
PRK10879 PRK10879
proline aminopeptidase P II; Provisional
 27-481 7.78e-73

proline aminopeptidase P II; Provisional


Pssm-ID: 182804 [Multi-domain]  Cd Length: 438  Bit Score: 237.31  E-value: 7.78e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008  27 RQRLCERLrknpavQAGSIVVLQGGEETQRyCTDTGVLFRQESFFHWAFGVTEPGCYGVI---DVDTGKSTLF--VPRLP 101
Cdd:PRK10879  10 RQALLAKM------QPGSAALIFAAPEATR-SADSEYPYRQNSDFWYFTGFNEPEAVLVLiksDDTHNHSVLFnrVRDLT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 102 AShaTWMGKIHSKEHFKEKYAVDDVQYVDEIASvltsQKPSVLLTLRGVNTDSG--SVCREASFDGISK--------FEV 171
Cdd:PRK10879  83 AE--IWFGRRLGQDAAPEKLGVDRALPFSEINQ----QLYQLLNGLDVVYHAQGeyAYADEIVFSALEKlrkgsrqnLTA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 172 NNTIL--HPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYcYSRGGMRHSSYTCICGSGE 249
Cdd:PRK10879 157 PATLTdwRPWVHEMRLFKSPEEIAVLRRAGEISALAHTRAMEKCRPGMFEYQLEGEIHHE-FNRHGARYPSYNTIVGSGE 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 250 NSAVLHYghagAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDM 329
Cdd:PRK10879 236 NGCILHY----TENESEMRDGDLVLIDAGCEYKGYAGDITRTFPVNGKFTPAQREIYDIVLESLETSLRLYRPGTSIREV 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 330 HRLADRIHLEELAHMGILSGSVDAMV--QAHLgAVFMpHGLGHFLGIDVHDVGGYpeGVERidepglrslrtARHLQPGM 407
Cdd:PRK10879 312 TGEVVRIMVSGLVKLGILKGDVDQLIaeNAHR-PFFM-HGLSHWLGLDVHDVGVY--GQDR-----------SRILEPGM 376

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 149589008 408 VLTVEPGIYfidhlldeaLADPArasflnrEVLQRFRGFgGVRIEEDVVVTDSGIELLTC-VPRTVEEIEACMAG 481
Cdd:PRK10879 377 VLTVEPGLY---------IAPDA-------DVPEQYRGI-GIRIEDDIVITETGNENLTAsVVKKPDEIEALMAA 434
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 193-459 4.15e-63

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 204.01  E-value: 4.15e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008  193 EVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYghagAPNDRTIQNGDM 272
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGVTERELAAELEAARLRRGGARGPAFPPIVASGPNAAIPHY----IPNDRVLKPGDL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008  273 CLFDMGGEY-YCFASDITCSFpANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIhleeLAHMGILsgsv 351
Cdd:pfam00557  77 VLIDVGAEYdGGYCSDITRTF-VVGKPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREV----LEEAGLG---- 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008  352 damvqahlgaVFMPHGLGHFLGIDVHdvggypegveriDEPGLRSLRTARHLQPGMVLTVEPGIYFIDhlldealadpar 431
Cdd:pfam00557 148 ----------EYFPHGLGHGIGLEVH------------EGPYISRGGDDRVLEPGMVFTIEPGIYFIP------------ 193

                         250       260
                  ....*....|....*....|....*...
gi 149589008  432 asflnrevlqrfrGFGGVRIEEDVVVTD 459
Cdd:pfam00557 194 -------------GWGGVRIEDTVLVTE 208
AMP_N smart01011
Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the ...
 18-155 3.05e-40

Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the creatinase N-terminal domain. However, little or no sequence similarity exists between the two families.


Pssm-ID: 198079  Cd Length: 135  Bit Score: 141.61  E-value: 3.05e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008    18 VPLALFALNRQRLCERLrknpavQAGSIVVLQGGEETQRYCtDTGVLFRQESFFHWAFGVTEPGCYGVIDV--DTGKSTL 95
Cdd:smart01011   1 IPAAEYAARRRRLAAKL------FPGSVAVLPAGPEKVRSN-DTDYPFRQDSDFYYLTGFDEPDAVLVLDPsgGGGKSTL 73

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 149589008    96 FVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTS--QKPSVLLTLRGVNTDSG 155
Cdd:smart01011  74 FVPPRDPEDELWDGPRLGLEEAKEKFGVDEVYPIDELDAVLPGllAGAGTVYYLLGRDPDLD 135
AMP_N pfam05195
Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the ...
 23-138 9.07e-38

Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the creatinase N-terminal domain (pfam01321). However, little or no sequence similarity exists between the two families.


Pssm-ID: 461581 [Multi-domain]  Cd Length: 121  Bit Score: 134.17  E-value: 9.07e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008   23 FALNRQRLCERLrknpavQAGSIVVLQGGEETQRYCtDTGVLFRQESFFHWAFGVTEPGCYGVI---DVDTGKSTLFVPR 99
Cdd:pfam05195   1 YAERRARLLAKL------PPNSVAILPGAPEKYRNG-DVFYPFRQDSDFYYLTGFNEPDAVLVLeggDIDSGKETLFVPP 73

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 149589008  100 LPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTS 138
Cdd:pfam05195  74 KDPEDEIWDGPRLGPEEAKELFGVDEVYPIDELDEVLPK 112
 
Name Accession Description Interval E-value
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
 192-467 3.69e-130

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 377.30  E-value: 3.69e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 192 LEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSgeNSAVLHYGHagapNDRTIQNGD 271
Cdd:cd01087    1 IELMRKACDISAEAHRAAMKASRPGMSEYELEAEFEYEFRSRGARLAYSYIVAAGS--NAAILHYVH----NDQPLKDGD 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 272 MCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSV 351
Cdd:cd01087   75 LVLIDAGAEYGGYASDITRTFPVNGKFTDEQRELYEAVLAAQKAAIAACKPGVSYEDIHLLAHRVLAEGLKELGILKGDV 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 352 DAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYpegveridepgLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEaladpar 431
Cdd:cd01087  155 DEIVESGAYAKFFPHGLGHYLGLDVHDVGGY-----------LRYLRRARPLEPGMVITIEPGIYFIPDLLDV------- 216

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 149589008 432 asflnrevlQRFRGFGGVRIEEDVVVTDSGIELLTC 467
Cdd:cd01087  217 ---------PEYFRGGGIRIEDDVLVTEDGPENLTR 243
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
178-475 2.17e-75

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 239.34  E-value: 2.17e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 178 PEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHsSYTCICGSGENSAVLHYG 257
Cdd:COG0006   65 DLLEELRAIKSPEEIELMRKAARIADAAHEAALAALRPGVTEREVAAELEAAMRRRGAEGP-SFDTIVASGENAAIPHYT 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 258 hagaPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPAnGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLAdrih 337
Cdd:COG0006  144 ----PTDRPLKPGDLVLIDAGAEYDGYTSDITRTVAV-GEPSDEQREIYEAVLEAQEAAIAALKPGVTGGEVDAAA---- 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 338 leelahmgilsgsVDAMVQAHLGAvFMPHGLGHFLGIDVHDVGGYPEGVERIdepglrslrtarhLQPGMVLTVEPGIYF 417
Cdd:COG0006  215 -------------RDVLAEAGYGE-YFPHGTGHGVGLDVHEGPQISPGNDRP-------------LEPGMVFTIEPGIYI 267

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 149589008 418 IdhlldealadparasflnrevlqrfrGFGGVRIEEDVVVTDSGIELLTCVPRTVEEI 475
Cdd:COG0006  268 P--------------------------GIGGVRIEDTVLVTEDGAEVLTRLPRELLEL 299
PRK10879 PRK10879
proline aminopeptidase P II; Provisional
 27-481 7.78e-73

proline aminopeptidase P II; Provisional


Pssm-ID: 182804 [Multi-domain]  Cd Length: 438  Bit Score: 237.31  E-value: 7.78e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008  27 RQRLCERLrknpavQAGSIVVLQGGEETQRyCTDTGVLFRQESFFHWAFGVTEPGCYGVI---DVDTGKSTLF--VPRLP 101
Cdd:PRK10879  10 RQALLAKM------QPGSAALIFAAPEATR-SADSEYPYRQNSDFWYFTGFNEPEAVLVLiksDDTHNHSVLFnrVRDLT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 102 AShaTWMGKIHSKEHFKEKYAVDDVQYVDEIASvltsQKPSVLLTLRGVNTDSG--SVCREASFDGISK--------FEV 171
Cdd:PRK10879  83 AE--IWFGRRLGQDAAPEKLGVDRALPFSEINQ----QLYQLLNGLDVVYHAQGeyAYADEIVFSALEKlrkgsrqnLTA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 172 NNTIL--HPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYcYSRGGMRHSSYTCICGSGE 249
Cdd:PRK10879 157 PATLTdwRPWVHEMRLFKSPEEIAVLRRAGEISALAHTRAMEKCRPGMFEYQLEGEIHHE-FNRHGARYPSYNTIVGSGE 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 250 NSAVLHYghagAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDM 329
Cdd:PRK10879 236 NGCILHY----TENESEMRDGDLVLIDAGCEYKGYAGDITRTFPVNGKFTPAQREIYDIVLESLETSLRLYRPGTSIREV 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 330 HRLADRIHLEELAHMGILSGSVDAMV--QAHLgAVFMpHGLGHFLGIDVHDVGGYpeGVERidepglrslrtARHLQPGM 407
Cdd:PRK10879 312 TGEVVRIMVSGLVKLGILKGDVDQLIaeNAHR-PFFM-HGLSHWLGLDVHDVGVY--GQDR-----------SRILEPGM 376

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 149589008 408 VLTVEPGIYfidhlldeaLADPArasflnrEVLQRFRGFgGVRIEEDVVVTDSGIELLTC-VPRTVEEIEACMAG 481
Cdd:PRK10879 377 VLTVEPGLY---------IAPDA-------DVPEQYRGI-GIRIEDDIVITETGNENLTAsVVKKPDEIEALMAA 434
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 193-459 4.15e-63

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 204.01  E-value: 4.15e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008  193 EVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYghagAPNDRTIQNGDM 272
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGVTERELAAELEAARLRRGGARGPAFPPIVASGPNAAIPHY----IPNDRVLKPGDL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008  273 CLFDMGGEY-YCFASDITCSFpANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIhleeLAHMGILsgsv 351
Cdd:pfam00557  77 VLIDVGAEYdGGYCSDITRTF-VVGKPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREV----LEEAGLG---- 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008  352 damvqahlgaVFMPHGLGHFLGIDVHdvggypegveriDEPGLRSLRTARHLQPGMVLTVEPGIYFIDhlldealadpar 431
Cdd:pfam00557 148 ----------EYFPHGLGHGIGLEVH------------EGPYISRGGDDRVLEPGMVFTIEPGIYFIP------------ 193

                         250       260
                  ....*....|....*....|....*...
gi 149589008  432 asflnrevlqrfrGFGGVRIEEDVVVTD 459
Cdd:pfam00557 194 -------------GWGGVRIEDTVLVTE 208
PRK13607 PRK13607
proline dipeptidase; Provisional
 184-466 8.09e-62

proline dipeptidase; Provisional


Pssm-ID: 237444 [Multi-domain]  Cd Length: 443  Bit Score: 208.21  E-value: 8.09e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 184 RVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELEslfEHYCYSRGgmrHSS----YTCICGSGENSAVLHY--- 256
Cdd:PRK13607 159 RAYKTDYELACMREAQKIAVAGHRAAKEAFRAGMSEFDIN---LAYLTATG---QRDndvpYGNIVALNEHAAVLHYtkl 232

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 257 GHAGAPNDRTIqngdmcLFDMGGEYYCFASDITCSFPANGK--FTADQKAVYEAVLrssrAVMGAMKPGVWWPDMHRLAd 334
Cdd:PRK13607 233 DHQAPAEMRSF------LIDAGAEYNGYAADITRTYAAKEDndFAALIKDVNKEQL----ALIATMKPGVSYVDLHIQM- 301

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 335 rihLEELAHM----GILSG-SVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYpegveRIDEPGLR--------SLRTAR 401
Cdd:PRK13607 302 ---HQRIAKLlrkfQIVTGlSEEAMVEQGITSPFFPHGLGHPLGLQVHDVAGF-----MQDDRGTHlaapekhpYLRCTR 373

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 149589008 402 HLQPGMVLTVEPGIYFIDHLLDEALADPaRASFLNREVLQRFRGFGGVRIEEDVVVTDSGIELLT 466
Cdd:PRK13607 374 VLEPGMVLTIEPGLYFIDSLLAPLREGP-FSKHFNWQKIDALKPFGGIRIEDNVVVHENGVENMT 437
APP-like cd01092
Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse ...
 192-461 1.09e-40

Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline.


Pssm-ID: 238525 [Multi-domain]  Cd Length: 208  Bit Score: 145.34  E-value: 1.09e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 192 LEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGmRHSSYTCICGSGENSAVLHyGHAGapnDRTIQNGD 271
Cdd:cd01092    1 IELLRKAARIADKAFEELLEFIKPGMTEREVAAELEYFMRKLGA-EGPSFDTIVASGPNSALPH-GVPS---DRKIEEGD 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 272 MCLFDMGGEY--YCfaSDITCSFpANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIhLEElahmgilsg 349
Cdd:cd01092   76 LVLIDFGAIYdgYC--SDITRTV-AVGEPSDELKEIYEIVLEAQQAAIKAVKPGVTAKEVDKAARDV-IEE--------- 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 350 svdamvqAHLGAVFmPHGLGHFLGIDVHDvggypegveridEPGLRSlRTARHLQPGMVLTVEPGIYFidhlldealadP 429
Cdd:cd01092  143 -------AGYGEYF-IHRTGHGVGLEVHE------------APYISP-GSDDVLEEGMVFTIEPGIYI-----------P 190

                        250       260       270
                 ....*....|....*....|....*....|..
gi 149589008 430 arasflnrevlqrfrGFGGVRIEEDVVVTDSG 461
Cdd:cd01092  191 ---------------GKGGVRIEDDVLVTEDG 207
AMP_N smart01011
Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the ...
 18-155 3.05e-40

Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the creatinase N-terminal domain. However, little or no sequence similarity exists between the two families.


Pssm-ID: 198079  Cd Length: 135  Bit Score: 141.61  E-value: 3.05e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008    18 VPLALFALNRQRLCERLrknpavQAGSIVVLQGGEETQRYCtDTGVLFRQESFFHWAFGVTEPGCYGVIDV--DTGKSTL 95
Cdd:smart01011   1 IPAAEYAARRRRLAAKL------FPGSVAVLPAGPEKVRSN-DTDYPFRQDSDFYYLTGFDEPDAVLVLDPsgGGGKSTL 73

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 149589008    96 FVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTS--QKPSVLLTLRGVNTDSG 155
Cdd:smart01011  74 FVPPRDPEDELWDGPRLGLEEAKEKFGVDEVYPIDELDAVLPGllAGAGTVYYLLGRDPDLD 135
AMP_N pfam05195
Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the ...
 23-138 9.07e-38

Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the creatinase N-terminal domain (pfam01321). However, little or no sequence similarity exists between the two families.


Pssm-ID: 461581 [Multi-domain]  Cd Length: 121  Bit Score: 134.17  E-value: 9.07e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008   23 FALNRQRLCERLrknpavQAGSIVVLQGGEETQRYCtDTGVLFRQESFFHWAFGVTEPGCYGVI---DVDTGKSTLFVPR 99
Cdd:pfam05195   1 YAERRARLLAKL------PPNSVAILPGAPEKYRNG-DVFYPFRQDSDFYYLTGFNEPDAVLVLeggDIDSGKETLFVPP 73

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 149589008  100 LPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTS 138
Cdd:pfam05195  74 KDPEDEIWDGPRLGPEEAKELFGVDEVYPIDELDEVLPK 112
APP_MetAP cd01066
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
 192-461 6.91e-35

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


Pssm-ID: 238514 [Multi-domain]  Cd Length: 207  Bit Score: 129.50  E-value: 6.91e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 192 LEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGmrHSSYTCICGSGENSAVLHYGhagaPNDRTIQNGD 271
Cdd:cd01066    1 IARLRKAAEIAEAAMAAAAEAIRPGVTEAEVAAAIEQALRAAGG--YPAGPTIVGSGARTALPHYR----PDDRRLQEGD 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 272 MCLFDMGGEYYCFASDITCSFPaNGKFTADQKAVYEAVLRSSRAVMGAMKPGVwwpdmhrladriHLEELAHMgilsgsV 351
Cdd:cd01066   75 LVLVDLGGVYDGYHADLTRTFV-IGEPSDEQRELYEAVREAQEAALAALRPGV------------TAEEVDAA------A 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 352 DAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGveridepglrslrTARHLQPGMVLTVEPGIYfidhlldealadpar 431
Cdd:cd01066  136 REVLEEHGLGPNFGHRTGHGIGLEIHEPPVLKAG-------------DDTVLEPGMVFAVEPGLY--------------- 187

                        250       260       270
                 ....*....|....*....|....*....|
gi 149589008 432 asflnrevlqrFRGFGGVRIEEDVVVTDSG 461
Cdd:cd01066  188 -----------LPGGGGVRIEDTVLVTEDG 206
PRK09795 PRK09795
aminopeptidase; Provisional
 170-472 9.27e-26

aminopeptidase; Provisional


Pssm-ID: 182080 [Multi-domain]  Cd Length: 361  Bit Score: 108.10  E-value: 9.27e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 170 EVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRhSSYTCICGSGE 249
Cdd:PRK09795 111 ELNAKLVSATPDVLRQIKTPEEVEKIRLACGIADRGAEHIRRFIQAGMSEREIAAELEWFMRQQGAEK-ASFDTIVASGW 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 250 NSAVLHyghaGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQK----AVYEAVLRSSRAVMGAMKPGVw 325
Cdd:PRK09795 190 RGALPH----GKASDKIVAAGEFVTLDFGALYQGYCSDMTRTLLVNGEGVSAEShplfNVYQIVLQAQLAAISAIRPGV- 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 326 wpdmhrladrihleelAHMGILSGSVDAMVQAHLGAVFmPHGLGHFLGIDVHDvggypegveridEPGLRSLRTARhLQP 405
Cdd:PRK09795 265 ----------------RCQQVDDAARRVITEAGYGDYF-GHNTGHAIGIEVHE------------DPRFSPRDTTT-LQP 314

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 149589008 406 GMVLTVEPGIYFidhlldealadPARasflnrevlqrfrgfGGVRIEEDVVVTDSGIELLTCVPRTV 472
Cdd:PRK09795 315 GMLLTVEPGIYL-----------PGQ---------------GGVRIEDVVLVTPQGAEVLYAMPKTV 355
APP cd01085
X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline ...
 219-463 3.28e-16

X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide.


Pssm-ID: 238518 [Multi-domain]  Cd Length: 224  Bit Score: 77.60  E-value: 3.28e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 219 EYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYgHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFpANGKF 298
Cdd:cd01085   32 ELSAADKLEEFRRQQKGYVGLSFDTISGFGPNGAIVHY-SPTEESNRKISPDGLYLIDSGGQYLDGTTDITRTV-HLGEP 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 299 TADQKAVYEAVL----RSSRAVmgamkpgvwWPDmhrladrihleelahmGILSGSVDAMVQAHLGAVFMP------HGL 368
Cdd:cd01085  110 TAEQKRDYTLVLkghiALARAK---------FPK----------------GTTGSQLDALARQPLWKAGLDyghgtgHGV 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 369 GHFLGidVHdvggypEGVERIdepglRSLRTARHLQPGMVLTVEPGIYfidhlldealadparasflnREvlqrfrGFGG 448
Cdd:cd01085  165 GSFLN--VH------EGPQSI-----SPAPNNVPLKAGMILSNEPGYY--------------------KE------GKYG 205

                        250
                 ....*....|....*
gi 149589008 449 VRIEEDVVVTDSGIE 463
Cdd:cd01085  206 IRIENLVLVVEAETT 220
PRK12896 PRK12896
methionine aminopeptidase; Reviewed
 187-466 6.78e-09

methionine aminopeptidase; Reviewed


Pssm-ID: 237252 [Multi-domain]  Cd Length: 255  Bit Score: 56.77  E-value: 6.78e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 187 KTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMrhSSY---------TCICgsgENSAVLHyg 257
Cdd:PRK12896  11 KSPRELEKMRKIGRIVATALKEMGKAVEPGMTTKELDRIAEKRLEEHGAI--PSPegyygfpgsTCIS---VNEEVAH-- 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 258 haGAPNDRTIQNGDMCLFDMGGEYYCFASDiTC-SFPAnGKFTADQKAVYEAVLRSSRAVMGAMKPGVwwpdmhRLADri 336
Cdd:PRK12896  84 --GIPGPRVIKDGDLVNIDVSAYLDGYHGD-TGiTFAV-GPVSEEAEKLCRVAEEALWAGIKQVKAGR------PLND-- 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 337 hleelahmgiLSGSVDAMVQAHLGAV---FMPHGLGHFLgidvHDvggYPEGVERIDEPGLRslrtaRHLQPGMVLTVEP 413
Cdd:PRK12896 152 ----------IGRAIEDFAKKNGYSVvrdLTGHGVGRSL----HE---EPSVILTYTDPLPN-----RLLRPGMTLAVEP 209

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 149589008 414 ----GIYFIDHLLDE--ALADPARASflnrevlqrfrgfggVRIEEDVVVTDSGIELLT 466
Cdd:PRK12896 210 flnlGAKDAETLDDGwtVVTPDKSLS---------------AQFEHTVVVTRDGPEILT 253
MetAP1 cd01086
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 192-467 8.39e-09

Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238519 [Multi-domain]  Cd Length: 238  Bit Score: 55.96  E-value: 8.39e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 192 LEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGmrHSS---------YTCICgsgENSAVLHyghaGAP 262
Cdd:cd01086    1 IEGMREAGRIVAEVLDELAKAIKPGVTTKELDQIAHEFIEEHGA--YPAplgyygfpkSICTS---VNEVVCH----GIP 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 263 NDRTIQNGDMCLFDMGGEYYCFASDITCSFPAnGKFTADQKAVYEAVLRSSRAVMGAMKPGVwwpdmhRLADrihleela 342
Cdd:cd01086   72 DDRVLKDGDIVNIDVGVELDGYHGDSARTFIV-GEVSEEAKKLVEVTEEALYKGIEAVKPGN------RIGD-------- 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 343 hmgilsgsVDAMVQAHLGAvfmpHGL-------GHFLGIDVHdvggypegvERIDEPGLRSLRTARHLQPGMVLTVEP-- 413
Cdd:cd01086  137 --------IGHAIEKYAEK----NGYsvvrefgGHGIGRKFH---------EEPQIPNYGRPGTGPKLKPGMVFTIEPmi 195

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 414 --GIYFIDHLLDE---ALADPAR-ASFlnrevlqrfrgfggvriEEDVVVTDSGIELLTC 467
Cdd:cd01086  196 nlGTYEVVTLPDGwtvVTKDGSLsAQF-----------------EHTVLITEDGPEILTL 238
PRK15173 PRK15173
peptidase; Provisional
 182-470 4.17e-07

peptidase; Provisional


Pssm-ID: 185095 [Multi-domain]  Cd Length: 323  Bit Score: 51.64  E-value: 4.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 182 ECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLhyghagA 261
Cdd:PRK15173  91 ELRVIKSPWEIKRLRKSAEITEYGITEASKLIRVGCTSAELTAAYKAAVMSKSETHFSRFHLISVGADFSPKL------I 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 262 PNDRTIQNGDMCLFDMGGEYYCFASDITCSFPAnGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLAdrihLEEL 341
Cdd:PRK15173 165 PSNTKACSGDLIKFDCGVDVDGYGADIARTFVV-GEPPEITRKIYQTIRTGHEHMLSMVAPGVKMKDVFDST----MEVI 239

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 342 AHMGILSGSvdamvQAHLGavfmpHGLGHFLGidvhdvggypegverIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDhl 421
Cdd:PRK15173 240 KKSGLPNYN-----RGHLG-----HGNGVFLG---------------LEESPFVSTHATESFTSGMVLSLETPYYGYN-- 292

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 149589008 422 ldealadparasflnrevlqrfrgFGGVRIEEDVVVTDSGIELLTCVPR 470
Cdd:PRK15173 293 ------------------------LGSIMIEDMILINKEGIEFLSKLPR 317
PRK14575 PRK14575
putative peptidase; Provisional
 182-470 7.68e-07

putative peptidase; Provisional


Pssm-ID: 173039 [Multi-domain]  Cd Length: 406  Bit Score: 51.25  E-value: 7.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 182 ECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLhyghagA 261
Cdd:PRK14575 174 ELRVIKSPWEIKRLRKSAEITEYGITEASKLIRVGCTSAELTAAYKAAVMSKSETHFSRFHLISVGADFSPKL------I 247

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 262 PNDRTIQNGDMCLFDMGGEYYCFASDITCSFPAnGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLAdrihLEEL 341
Cdd:PRK14575 248 PSNTKACSGDLIKFDCGVDVDGYGADIARTFVV-GEPPEITRKIYQTIRTGHEHMLSMVAPGVKMKDVFDST----MEVI 322

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 342 AHMGILSGSvdamvQAHLGavfmpHGLGHFLGidvhdvggypegverIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDhl 421
Cdd:PRK14575 323 KKSGLPNYN-----RGHLG-----HGNGVFLG---------------LEESPFVSTHATESFTSGMVLSLETPYYGYN-- 375

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 149589008 422 ldealadparasflnrevlqrfrgFGGVRIEEDVVVTDSGIELLTCVPR 470
Cdd:PRK14575 376 ------------------------LGSIMIEDMILINKEGIEFLSKLPR 400
PRK12318 PRK12318
methionyl aminopeptidase;
185-466 7.96e-07

methionyl aminopeptidase;


Pssm-ID: 183434 [Multi-domain]  Cd Length: 291  Bit Score: 50.59  E-value: 7.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 185 VFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYcysrggmrHSSYTCIcgsgenSAVLHYGHA----- 259
Cdd:PRK12318  42 IIKTPEQIEKIRKACQVTARILDALCEAAKEGVTTNELDELSREL--------HKEYNAI------PAPLNYGSPpfpkt 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 260 -----------GAPNDRTIQNGDM------CLFDmggEYYCFASDITCSfpanGKFTADQKAVYEAVLRSSRAVMGAMKP 322
Cdd:PRK12318 108 ictslnevichGIPNDIPLKNGDImnidvsCIVD---GYYGDCSRMVMI----GEVSEIKKKVCQASLECLNAAIAILKP 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 323 GVwwpDMHRLADRIhlEELAHMGILSgSVDAMVqahlgavfmphglGHFLGIDVHDVGGYPEGVERIDEPglrslrtarh 402
Cdd:PRK12318 181 GI---PLYEIGEVI--ENCADKYGFS-VVDQFV-------------GHGVGIKFHENPYVPHHRNSSKIP---------- 231

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 149589008 403 LQPGMVLTVEPgiyFIDHLLDEALADParasfLNREVLQRFRGFGGVRIEEDVVVTDSGIELLT 466
Cdd:PRK12318 232 LAPGMIFTIEP---MINVGKKEGVIDP-----INHWEARTCDNQPSAQWEHTILITETGYEILT 287
PRK05716 PRK05716
methionine aminopeptidase; Validated
 187-466 1.22e-06

methionine aminopeptidase; Validated


Pssm-ID: 235576 [Multi-domain]  Cd Length: 252  Bit Score: 49.75  E-value: 1.22e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 187 KTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRG---------GMRHSsytcICGSgENSAVLHyg 257
Cdd:PRK05716   6 KTPEEIEKMRVAGRLAAEVLDEIEPHVKPGVTTKELDRIAEEYIRDQGaipaplgyhGFPKS----ICTS-VNEVVCH-- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 258 haGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPAnGKFTADQKAVYEAVLRSSRAVMGAMKPGVwwpdmhRLADRIH 337
Cdd:PRK05716  79 --GIPSDKVLKEGDIVNIDVTVIKDGYHGDTSRTFGV-GEISPEDKRLCEVTKEALYLGIAAVKPGA------RLGDIGH 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 338 -LEELAHmgilsgsvdamvQAHLGAV--FMPHGLGHFLgidvHD---VGGYpegveriDEPGlrslrTARHLQPGMVLTV 411
Cdd:PRK05716 150 aIQKYAE------------AEGFSVVreYCGHGIGRKF----HEepqIPHY-------GAPG-----DGPVLKEGMVFTI 201

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 149589008 412 EP----GIYFIDHLLDEALADPARASFlnrevlqrfrgfgGVRIEEDVVVTDSGIELLT 466
Cdd:PRK05716 202 EPminaGKREVKTLKDGWTVVTKDGSL-------------SAQYEHTVAVTEDGPEILT 247
PRK14576 PRK14576
putative endopeptidase; Provisional
 171-474 1.20e-04

putative endopeptidase; Provisional


Pssm-ID: 173040 [Multi-domain]  Cd Length: 405  Bit Score: 44.24  E-value: 1.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 171 VNNTILHPEIvecRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCIcGSGEN 250
Cdd:PRK14576 165 VDSTALFNEI---RMIKSPWEIEHLRKSAEITEYGIASAAKKIRVGCTAAELTAAFKAAVMSFPETNFSRFNLI-SVGDN 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 251 savlhYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFpANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDM- 329
Cdd:PRK14576 241 -----FSPKIIADTTPAKVGDLIKFDCGIDVAGYGADLARTF-VLGEPDKLTQQIYDTIRTGHEHMLSMVAPGVKLKAVf 314

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149589008 330 HRLADRIHLEELAHMGilsgsvdamvQAHLGavfmpHGLGHFLGidvhdvggypegverIDEPGLRSLRTARHLQPGMVL 409
Cdd:PRK14576 315 DSTMAVIKTSGLPHYN----------RGHLG-----HGDGVFLG---------------LEEVPFVSTQATETFCPGMVL 364

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 149589008 410 TVEPGIYFIdhlldealadparasflnrevlqrfrGFGGVRIEEDVVVTDSGIELLTCVPRTVEE 474
Cdd:PRK14576 365 SLETPYYGI--------------------------GVGSIMLEDMILITDSGFEFLSKLDRDLRR 403
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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