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Conserved domains on  [gi|1494809266|ref|XP_026691633|]
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gap junction gamma-2 protein-like [Ciona intestinalis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Connexin super family cl37952
Connexin; Connexin proteins form gap-junctions between cells. They carry four transmembrane ...
 25-118 1.04e-39

Connexin; Connexin proteins form gap-junctions between cells. They carry four transmembrane regions, hence why this family now includes Connexin_CCC, which represented the second pair of TMs.


The actual alignment was detected with superfamily member pfam00029:

Pssm-ID: 459638 [Multi-domain]  Cd Length: 217  Bit Score: 134.55  E-value: 1.04e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494809266  25 ELHKTRGQcIWRLYLLQIFSRMLIECVFIMLQYtvYFYRWTVPQVFRCQVWPCPHTVDCFISRPQEKTVFFRYMYVISAF 104
Cdd:pfam00029 127 PKVHIRGG-LLWTYVLSLLFRIVLEVGFLVGQY--YLYGFEVPPLFKCSRSPCPNTVDCFVSRPTEKTIFLLFMFVVSGL 203

                          90
                  ....*....|....
gi 1494809266 105 SILLSIGELLYIGW 118
Cdd:pfam00029 204 CLLLNLLELFYLGW 217
 
Name Accession Description Interval E-value
Connexin pfam00029
Connexin; Connexin proteins form gap-junctions between cells. They carry four transmembrane ...
 25-118 1.04e-39

Connexin; Connexin proteins form gap-junctions between cells. They carry four transmembrane regions, hence why this family now includes Connexin_CCC, which represented the second pair of TMs.


Pssm-ID: 459638 [Multi-domain]  Cd Length: 217  Bit Score: 134.55  E-value: 1.04e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494809266  25 ELHKTRGQcIWRLYLLQIFSRMLIECVFIMLQYtvYFYRWTVPQVFRCQVWPCPHTVDCFISRPQEKTVFFRYMYVISAF 104
Cdd:pfam00029 127 PKVHIRGG-LLWTYVLSLLFRIVLEVGFLVGQY--YLYGFEVPPLFKCSRSPCPNTVDCFVSRPTEKTIFLLFMFVVSGL 203

                          90
                  ....*....|....
gi 1494809266 105 SILLSIGELLYIGW 118
Cdd:pfam00029 204 CLLLNLLELFYLGW 217
Connexin_CCC smart01089
Gap junction channel protein cysteine-rich domain;
48-116 8.19e-32

Gap junction channel protein cysteine-rich domain;


Pssm-ID: 198157  Cd Length: 67  Bit Score: 109.50  E-value: 8.19e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1494809266   48 IECVFIMLQYtvYFYRWTVPQVFRCQVWPCPHTVDCFISRPQEKTVFFRYMYVISAFSILLSIGELLYI 116
Cdd:smart01089   1 LEVGFLYGQY--YLYGFQVPPLYKCSRSPCPNTVDCFVSRPTEKTIFLIFMLVVSAICILLNLLELFYL 67
 
Name Accession Description Interval E-value
Connexin pfam00029
Connexin; Connexin proteins form gap-junctions between cells. They carry four transmembrane ...
 25-118 1.04e-39

Connexin; Connexin proteins form gap-junctions between cells. They carry four transmembrane regions, hence why this family now includes Connexin_CCC, which represented the second pair of TMs.


Pssm-ID: 459638 [Multi-domain]  Cd Length: 217  Bit Score: 134.55  E-value: 1.04e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494809266  25 ELHKTRGQcIWRLYLLQIFSRMLIECVFIMLQYtvYFYRWTVPQVFRCQVWPCPHTVDCFISRPQEKTVFFRYMYVISAF 104
Cdd:pfam00029 127 PKVHIRGG-LLWTYVLSLLFRIVLEVGFLVGQY--YLYGFEVPPLFKCSRSPCPNTVDCFVSRPTEKTIFLLFMFVVSGL 203

                          90
                  ....*....|....
gi 1494809266 105 SILLSIGELLYIGW 118
Cdd:pfam00029 204 CLLLNLLELFYLGW 217
Connexin_CCC smart01089
Gap junction channel protein cysteine-rich domain;
48-116 8.19e-32

Gap junction channel protein cysteine-rich domain;


Pssm-ID: 198157  Cd Length: 67  Bit Score: 109.50  E-value: 8.19e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1494809266   48 IECVFIMLQYtvYFYRWTVPQVFRCQVWPCPHTVDCFISRPQEKTVFFRYMYVISAFSILLSIGELLYI 116
Cdd:smart01089   1 LEVGFLYGQY--YLYGFQVPPLYKCSRSPCPNTVDCFVSRPTEKTIFLIFMLVVSAICILLNLLELFYL 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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