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Conserved domains on  [gi|1494293610|gb|AYN02587|]
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MFS transporter [Chryseobacterium sp. 3008163]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 1-378 6.14e-50

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17329:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 376  Bit Score: 172.03  E-value: 6.14e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610   1 MLALVMLINRSGSMVLPFLGVYMTAHLKFSIENTGIVLSFFGIGSVIGSWLGGFITDRIGEYKVQYLSLLLSVPLFCLIP 80
Cdd:cd17329     4 LLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  81 LFKTEASVALIILLQSIVSDSFRPANSVAITKYAKPENITRAFSLNRMAVNLGFSIGPALGGILSAISYDFLFYSNALAA 160
Cdd:cd17329    84 FAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLF 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 161 LLAGLIYIRFF--YKRNKLAKIKAKKVQEVMEIKKenspysDGKFLIYCFFCMLFSICFFQLFSTLTIFYKDTAHLSQQS 238
Cdd:cd17329   164 LLAALVLLFLLpeTRPKRRAAEKTEILRGYKIVLR------DRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESL 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 239 IGYILGYSGFLVVLLEMGLVQIAEKyFTLARTMFLGTFICGLSYAMLGFDHSILTLIVSMSLLSAGEIWALPFMSTITAL 318
Cdd:cd17329   238 LGLLLALNALLIVLLQFPVARLVER-FRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAA 316

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 319 RSGKNNKGAYMGLNGISFSIAFIVTPYLGTLIAEKFGFNILWIGTGILATMIAIGFYFIV 378
Cdd:cd17329   317 LAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
 
Name Accession Description Interval E-value
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 1-378 6.14e-50

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 172.03  E-value: 6.14e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610   1 MLALVMLINRSGSMVLPFLGVYMTAHLKFSIENTGIVLSFFGIGSVIGSWLGGFITDRIGEYKVQYLSLLLSVPLFCLIP 80
Cdd:cd17329     4 LLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  81 LFKTEASVALIILLQSIVSDSFRPANSVAITKYAKPENITRAFSLNRMAVNLGFSIGPALGGILSAISYDFLFYSNALAA 160
Cdd:cd17329    84 FAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLF 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 161 LLAGLIYIRFF--YKRNKLAKIKAKKVQEVMEIKKenspysDGKFLIYCFFCMLFSICFFQLFSTLTIFYKDTAHLSQQS 238
Cdd:cd17329   164 LLAALVLLFLLpeTRPKRRAAEKTEILRGYKIVLR------DRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESL 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 239 IGYILGYSGFLVVLLEMGLVQIAEKyFTLARTMFLGTFICGLSYAMLGFDHSILTLIVSMSLLSAGEIWALPFMSTITAL 318
Cdd:cd17329   238 LGLLLALNALLIVLLQFPVARLVER-FRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAA 316

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 319 RSGKNNKGAYMGLNGISFSIAFIVTPYLGTLIAEKFGFNILWIGTGILATMIAIGFYFIV 378
Cdd:cd17329   317 LAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-339 1.91e-25

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 105.44  E-value: 1.91e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610   1 MLALVMLINRSGSMVLPFLGVYMTAHLKFSIENTGIVLSFFGIGSVIGSWLGGFITDRIGEYKVQYLSLLLSVPLFCLIP 80
Cdd:COG2814    14 ALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  81 LFKTEASVALIILLQSIVSDSFRPANSVAITKYAKPENITRAFSLNRMAVNLGFSIGPALGGIL-SAISYDFLFYSNalA 159
Cdd:COG2814    94 LAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLaDLFGWRWVFLVN--A 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 160 ALLAGLIYIRFFYKRNKLAKIKAKKVQEVMEIKKenspysDGKFLIYCFFCMLFSICFFQLFSTLTIFYKDTAHLSQQSI 239
Cdd:COG2814   172 VLALLALLLLLRLLPESRPAARARLRGSLRELLR------RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAA 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 240 GYILGYSGFLVVLLEMGLVQIAEKyFTLARTMFLGTFICGLSYAMLGFDHSILTLIVSMSLLSAGEIWALPFMSTITALR 319
Cdd:COG2814   246 GLLLALFGLGGVLGALLAGRLADR-FGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAEL 324

                         330       340
                  ....*....|....*....|
gi 1494293610 320 SGKNNKGAYMGLNGISFSIA 339
Cdd:COG2814   325 APPEARGRASGLYNSAFFLG 344
MFS_1 pfam07690
Major Facilitator Superfamily;
11-344 2.50e-20

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 90.94  E-value: 2.50e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  11 SGSMVLPFLGVYMTAHLKFSIENTGIVLSFFGIGSVIGSWLGGFITDRIGEYKVQYLSLLLSVPLFCLIPLFKTEASVAL 90
Cdd:pfam07690  11 GRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLV 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  91 IILLQSIVSDSFRPANSVAITKYAKPENITRAFSLNRMAVNLGFSIGPALGGIL-SAISYDFLFYSNalAALLAGLIYIR 169
Cdd:pfam07690  91 LRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLaSLFGWRAAFLIL--AILSLLAAVLL 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 170 FFYKRNKLAKIKAKKVQEVMEIKKENSPYSDGKFLIYCFFCMLFSICFFQLFSTLTIfYKDTAHLSQQSIGYILGYSGFL 249
Cdd:pfam07690 169 LLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPL-YQEVLGLSALLAGLLLGLGGLL 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 250 VVLLEMGLVQIAEKYFTLARTMF--LGTFICGLSYAMLGFDHSILTLIVSMSLLSAGEIWALPFMSTITALRSGKNNKGA 327
Cdd:pfam07690 248 GAIGRLLLGRLSDRLGRRRRLLLalLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGT 327

                         330
                  ....*....|....*..
gi 1494293610 328 YMGLNGISFSIAFIVTP 344
Cdd:pfam07690 328 ASGLYNTAGSLGGALGP 344
PRK10054 PRK10054
efflux MFS transporter YdeE;
3-154 9.21e-06

efflux MFS transporter YdeE;


Pssm-ID: 182213  Cd Length: 395  Bit Score: 47.43  E-value: 9.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610   3 ALVMLINRSGSmvLPFLGVYMTAHLKFSIENTGIVLSFFGIGSVIGSWLGGFITDRIGEYKVQYLSLLLSVPLFCLIPLF 82
Cdd:PRK10054   16 SLLLTIGRGAT--LPFMTIYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLV 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1494293610  83 KteaSVALIILLQSIVSDSFRPANSVAITKYAK---PENITRAFSLNRMAVNLGFSIGPALGGILSAISYDFLFY 154
Cdd:PRK10054   94 N---NVTLVVLFFALINCAYSVFSTVLKAWFADnlsSTSKTKIFSLNYTMLNIGWTVGPPLGTLLVMQSINLPFW 165
 
Name Accession Description Interval E-value
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 1-378 6.14e-50

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 172.03  E-value: 6.14e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610   1 MLALVMLINRSGSMVLPFLGVYMTAHLKFSIENTGIVLSFFGIGSVIGSWLGGFITDRIGEYKVQYLSLLLSVPLFCLIP 80
Cdd:cd17329     4 LLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  81 LFKTEASVALIILLQSIVSDSFRPANSVAITKYAKPENITRAFSLNRMAVNLGFSIGPALGGILSAISYDFLFYSNALAA 160
Cdd:cd17329    84 FAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLF 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 161 LLAGLIYIRFF--YKRNKLAKIKAKKVQEVMEIKKenspysDGKFLIYCFFCMLFSICFFQLFSTLTIFYKDTAHLSQQS 238
Cdd:cd17329   164 LLAALVLLFLLpeTRPKRRAAEKTEILRGYKIVLR------DRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESL 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 239 IGYILGYSGFLVVLLEMGLVQIAEKyFTLARTMFLGTFICGLSYAMLGFDHSILTLIVSMSLLSAGEIWALPFMSTITAL 318
Cdd:cd17329   238 LGLLLALNALLIVLLQFPVARLVER-FRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAA 316

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 319 RSGKNNKGAYMGLNGISFSIAFIVTPYLGTLIAEKFGFNILWIGTGILATMIAIGFYFIV 378
Cdd:cd17329   317 LAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 2-378 3.14e-27

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 111.13  E-value: 3.14e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610   2 LALVMLINRSGSMVLPFLGVYMtAHLKFSIENTGIVLSFFGIGSVIGSWLGGFITDRIGEYKVQYLSLLLSVPLFCLIPL 81
Cdd:cd17325     2 SLALFLDMLGYGIIIPILPLYA-ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  82 FKTEASVALIILLQSIVSDSFRPANSVAITKYAKPENITRAFSLNRMAVNLGFSIGPALGGIL-SAISYDFLFYsnALAA 160
Cdd:cd17325    81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLaDALGYRAPFL--VCAA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 161 LLAGLIYIRFFYKRNKLAKIKAKKVQEVMEIKKENSPYSDGKFLIYCFFCMLFSICFFQLFSTLTIFYKDTAHLSQQSIG 240
Cdd:cd17325   159 LALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 241 YILGYSGFLVVLLEMGLVQIAEKYFTLaRTMFLGTFICGLSYAMLGFDHSILTLIVSMSLLSAGEIWALPFMSTITALRS 320
Cdd:cd17325   239 LLFGAQGLASALSQPPAGKLSDRIGRK-PLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIV 317

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1494293610 321 GKNNKGAYMGLNGISFSIAFIVTPYLGTLIAEKFGFNILWIGTGILATMIAIGFYFIV 378
Cdd:cd17325   318 PPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-339 1.91e-25

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 105.44  E-value: 1.91e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610   1 MLALVMLINRSGSMVLPFLGVYMTAHLKFSIENTGIVLSFFGIGSVIGSWLGGFITDRIGEYKVQYLSLLLSVPLFCLIP 80
Cdd:COG2814    14 ALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  81 LFKTEASVALIILLQSIVSDSFRPANSVAITKYAKPENITRAFSLNRMAVNLGFSIGPALGGIL-SAISYDFLFYSNalA 159
Cdd:COG2814    94 LAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLaDLFGWRWVFLVN--A 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 160 ALLAGLIYIRFFYKRNKLAKIKAKKVQEVMEIKKenspysDGKFLIYCFFCMLFSICFFQLFSTLTIFYKDTAHLSQQSI 239
Cdd:COG2814   172 VLALLALLLLLRLLPESRPAARARLRGSLRELLR------RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAA 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 240 GYILGYSGFLVVLLEMGLVQIAEKyFTLARTMFLGTFICGLSYAMLGFDHSILTLIVSMSLLSAGEIWALPFMSTITALR 319
Cdd:COG2814   246 GLLLALFGLGGVLGALLAGRLADR-FGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAEL 324

                         330       340
                  ....*....|....*....|
gi 1494293610 320 SGKNNKGAYMGLNGISFSIA 339
Cdd:COG2814   325 APPEARGRASGLYNSAFFLG 344
MFS_1 pfam07690
Major Facilitator Superfamily;
11-344 2.50e-20

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 90.94  E-value: 2.50e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  11 SGSMVLPFLGVYMTAHLKFSIENTGIVLSFFGIGSVIGSWLGGFITDRIGEYKVQYLSLLLSVPLFCLIPLFKTEASVAL 90
Cdd:pfam07690  11 GRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLV 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  91 IILLQSIVSDSFRPANSVAITKYAKPENITRAFSLNRMAVNLGFSIGPALGGIL-SAISYDFLFYSNalAALLAGLIYIR 169
Cdd:pfam07690  91 LRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLaSLFGWRAAFLIL--AILSLLAAVLL 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 170 FFYKRNKLAKIKAKKVQEVMEIKKENSPYSDGKFLIYCFFCMLFSICFFQLFSTLTIfYKDTAHLSQQSIGYILGYSGFL 249
Cdd:pfam07690 169 LLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPL-YQEVLGLSALLAGLLLGLGGLL 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 250 VVLLEMGLVQIAEKYFTLARTMF--LGTFICGLSYAMLGFDHSILTLIVSMSLLSAGEIWALPFMSTITALRSGKNNKGA 327
Cdd:pfam07690 248 GAIGRLLLGRLSDRLGRRRRLLLalLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGT 327

                         330
                  ....*....|....*..
gi 1494293610 328 YMGLNGISFSIAFIVTP 344
Cdd:pfam07690 328 ASGLYNTAGSLGGALGP 344
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 2-376 1.61e-18

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 85.71  E-value: 1.61e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610   2 LALVMLINR-SGSMVLPFLGVYMTAHLKF--SIENTGIVLSFFGIGSVIGSWLGGFITDRIGEYKVQYLSLLLSVPLFCL 78
Cdd:cd17330     1 LFLVVFLDAlGFGIVFPVLPFYVREFNKLgaSGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  79 IPLfkteaSVALIILLQSIVSDSFRPANSVAITKYA----KPENITRAFSLNRMAVNLGFSIGPALGGILSAISYDFLFY 154
Cdd:cd17330    81 LGL-----SRNLWLLFLARFLDGLTGGNVSVAQAYIaditDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPF 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 155 SNALAALLAGLIYIRFFYKRNKLAkikakkvqevmeikkenspysdgkFLIYCFFCMLFSIcffqLFSTLTIFYKDTAHL 234
Cdd:cd17330   156 LVAAALALLNLVLVLFFLPPLRRL------------------------LLVYFLIALAFAG----LESVFSLFLKDRFGF 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 235 SQQSIGYILGYSGFLVVLLEMGLVQIAEKYFTLARTMFLGTFICGLSYAMLGFDHSILTLIVSMSLLSAGEIWALPFMST 314
Cdd:cd17330   208 SPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSA 287

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1494293610 315 ITALRSGKNNKGAYMGLNGISFSIAFIVTPYLGTLIAEKFGFNILWIGTGILATMIAIGFYF 376
Cdd:cd17330   288 LLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 13-378 2.51e-18

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 85.70  E-value: 2.51e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  13 SMVLPFLgVYMTAHLKFSIENTGIVLSFFGIGSVIGSWLGGFITDRIGEYKVQYLSLLLSVpLFCLIPLFKTEASVALII 92
Cdd:cd17474    16 SIVDPIL-PAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFG-IGGLLCGLSDSFALLLAG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  93 -LLQSIVSDSFRPANSVAITKYAKPENITRAFSLNRMAVNLGFSIGPALGGILSAISYDFLFYsnALAALLAGLIYIRFF 171
Cdd:cd17474    94 rALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFF--LLAALIPVAFLAILF 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 172 YKRNKLAKIKAKKVQEVMEIKKEnspYSDGKFLIYCFFCMLFSICFFQLFSTLTIFYKDTAHLSQQSIGYILGYSGFLVV 251
Cdd:cd17474   172 LLPEPKEKAKSSSATKLRDLKKA---LRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLA 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 252 LLEMGLVQIAEKYFTLARTMFLGTFICGLSYAMLGFDHSILTLIVSMSLLSAGEIWALPFMSTITALRSGKNNKGAYMGL 331
Cdd:cd17474   249 LGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSL 328

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1494293610 332 NGISFSIAFIVTPYLGTLIAEKFGFNILWIgTGILATMIAIGFYFIV 378
Cdd:cd17474   329 YNFVRFLGQAVGPLLFGLLLEIFGLSAPFL-VGAAIALAAAVLLALL 374
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 2-375 6.98e-17

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 81.32  E-value: 6.98e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610   2 LALVMLINRSGSMVLPFLGVYMTAHLKFSIENTGIVLSFFGIGSVIGSWLGGFITDRIGEYKVQYLSLLLSVPLFCLIPL 81
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  82 FKTEASVALIILLQSIVSDSFRPANSVAITKYAKPENITRAFSLNRMAVNLGFSIGPALGGILSAISYD--FLFYSNALA 159
Cdd:cd06174    81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFgwRAVFLIAAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 160 ALLAGLIYIRFFYKRNKLAKIKAKKVQEVMEIKKENSP-YSDGKFLIYCFFCMLFSICFFQLFSTLTIFYKDTAHLSQQS 238
Cdd:cd06174   161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRvLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 239 IGYILGYSGFLVVLLEMGLVQIAEKYFTLARTMFLGTFICGLSYAMLGFDHSILTLIVSMSLLSAGEIWALPFMSTITAL 318
Cdd:cd06174   241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAE 320

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1494293610 319 RSGKNNKGAYMGLNGISFSIAFIVTPYL-GTLIAEKFGFNILWIGTGILATMIAIGFY 375
Cdd:cd06174   321 LFPPEIRGTAFGLLNTFGFLGGAIGPLLaGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 34-377 1.32e-15

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 77.66  E-value: 1.32e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  34 TGIVLSFFGIGSVIGSWLGGFITDRIGEYKVQYLSLLLSVPLFCLIPLFKTEASVALIIL-----LQSIVSDSFRPANSV 108
Cdd:cd06173    36 VGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLlvlafLLGIASAFFGPARQA 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 109 AITKYAKPENITRAFSLNRMAVNLGFSIGPALGGIL-SAISYDFLFYSNALAALLAGLIYirFFYKRNKLAKIKAKKVQE 187
Cdd:cd06173   116 LLPELVPKEQLVRANALNSLATQLARIIGPALGGLLvALLGPGGAFAINALSFLLSALLL--LFIRRPPPAAPGESSSLL 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 188 VMEIKKENSPYSDGKFLIYCFFCMLFSICFFQLFSTLTIFY-KDTAHLSQQSIGYILGySGFLVVLLEMGLVQIAEKYFT 266
Cdd:cd06173   194 LRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLaKEVLGGGAAGYGLLLA-AFGVGALLGALLLGRLSKRRR 272

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 267 LARTMFLGTFICGLSYAMLGFDHSILTLIVSMSLLSAGEIWALPFMSTITALRSGKNNKGAYMGLNGISFSIAFIVTPYL 346
Cdd:cd06173   273 RGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALL 352

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1494293610 347 GTLIAEKFGFNILWIGTGILATMIAIGFYFI 377
Cdd:cd06173   353 AGLLADALGLSAVFLLAGALLLLAALLLLLL 383
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 1-171 2.09e-14

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 73.76  E-value: 2.09e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610   1 MLALVMLINRSGSMVLPFLGVYMTAHLKFSIENTGIVLSFFGIGSVIGSWLGGFITDRIGEYKVQYLSLLLSVPLFCLIP 80
Cdd:cd17325   204 LFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLP 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  81 LFKTEASVALIILLQSIVSDSFRPANSVAITKYAKPENITRAFSLNRMAVNLGFSIGPALGGILS-AISYDFLFYSNALA 159
Cdd:cd17325   284 LATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYdAFGFATPFLAAAAL 363

                         170
                  ....*....|..
gi 1494293610 160 ALLAGLIYIRFF 171
Cdd:cd17325   364 LLLAAVLFLLLR 375
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
1-383 1.80e-13

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 71.05  E-value: 1.80e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610   1 MLALVMLINRSGSMVLPFLGVYMTAHLKFSIENTGIVLSFFGIGSVIGSWLGGFITDRIGEYKVQYLSLLLSVPLFCLIP 80
Cdd:COG2271    14 LLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  81 LFKTEASVALIILLQSIVSDSFRPANSVAITKYAKPENITRAFSLNRMAVNLGFSIGPALGG-ILSAISYDFLFYSNALA 159
Cdd:COG2271    94 FATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGwLLAAFGWRAAFLILGLP 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 160 ALLAGLIYIRffykrnklakikakkvqevmeikkenspysdgkFLIYCFFCMLFSICFFQLFstLTIFYKDTAHLSQQSI 239
Cdd:COG2271   174 GLLLALLRFW---------------------------------LLALAYFLVYFALYGFLTW--LPTYLVEVRGLSLAQA 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 240 GYILGYSGFLVVLLEMGLVQIAEKYFTLAR-TMFLGTFICGLSYAMLGFDHSILTLIVSMSLLSAGEIWALPFMSTITAL 318
Cdd:COG2271   219 GLLLSLPFLAGIVGSLLGGWLSDRLGRRRKlVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAE 298

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1494293610 319 RSGKNNKGAYMGLNGISFSIAFIVTPYLGTLIAEKFGFNILWIGTGILATMIAIGFYFIVPWMLK 383
Cdd:COG2271   299 LFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 11-376 1.01e-12

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 68.75  E-value: 1.01e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  11 SGSMVLPFLGVYMTAHLKFSIENTGIVLSFFGIGSVIGSWLGGFITDRIGEYKVQYLSLLLSVpLFCLIPLFKTeaSVAL 90
Cdd:cd17473    14 AGAAIAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYG-IGGVAGLFLD--SLYA 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  91 II---LLQSIVSDSFRPANSVAITKYAKPENITRAFSLNRMAVNLGFSIGPALGGILSAIS--YDFLFYSNALAALLAGL 165
Cdd:cd17473    91 LLasrALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGwrAPFLVYLLALPVLILVL 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 166 IYIRffykrnklaKIKAKKVQEVMEIKKENSPYSDGKFLIYCFFCMLFSICFFQLFSTLTIFYKDTAHLSQQSIGYILGY 245
Cdd:cd17473   171 LFLP---------EPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAI 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 246 SGFLVVLLEMGLVQIAeKYFTLARTMFLGTFICGLSYAMLGFDHSILTLIVSMSLLSAGEIWALPFMSTITALRSGKNNK 325
Cdd:cd17473   242 ASLAGAIGALLFGRLK-RRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELR 320

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1494293610 326 GAYMGLNGISFSIAFIVTPYL-GTLIAEKFGFNILWIGTGILATMIAIGFYF 376
Cdd:cd17473   321 GRAMGIVTSAFFLGQFLSPLVlGPLVNLTGGLSGAFLILGVLALVLAIVLLL 372
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 14-378 1.78e-12

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 68.00  E-value: 1.78e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  14 MVLPFLGVYmTAHLKFSIENTGIVLSFFGIGSVIGSWLGGFITDRIGEYKVQYLSLLLSVPLFCLIPLFKTEASVALIIL 93
Cdd:cd17489    14 LLLPVLPLY-AHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  94 LQSIVSDSFRPANSVAITKYAKPENITRAFSLNRMAVNLGFSIGPALGG-ILSAISYDFLFYSnaLAALLAGLIYIRFFY 172
Cdd:cd17489    93 IHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLfLYQHLGFAVLFIV--AAVLALLALLLVFLV 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 173 KRNKLAKIKAKKVQevmeiKKENSPYSDGKFLIYCFFCMLFSICFFQLFSTLTIFYkdtAHLSQQSIGYILGYSGFLVVL 252
Cdd:cd17489   171 KDPPPVAAEEAEAG-----TRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYA---AERGISNAGLFFTVYAIALLL 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 253 LEMGLVQIAEKYFTlARTMFLGTFICGLSYAMLGFDHSILTLIVSMSLLSAGEIWALPFMSTITALRSGKNNKGAYMGLN 332
Cdd:cd17489   243 SRPFSGKLSDRKGP-KTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTF 321

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 1494293610 333 GISFSIAFIVTPYLGTLIAEKFGFNILWIGTGILATMIAIGFYFIV 378
Cdd:cd17489   322 FIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 2-144 1.90e-10

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 61.80  E-value: 1.90e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610   2 LALVMLINRSGSMVLPFLGVYMTAHLKFSIENTGIVLSFFGIGSVIGSWLGGFITDRIGEYKVQYLSLLLSVPLFCLIPL 81
Cdd:cd17324   204 YLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLL 283

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1494293610  82 FKTEASVALIILLQSIVSDSFRPANSVAITKYAkPENITRAFSLNRMAVNLGFSIGPALGGIL 144
Cdd:cd17324   284 GPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLA-PEARGLASSLYLAAYNLGGALGAALGGLV 345
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 15-374 8.58e-10

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 59.93  E-value: 8.58e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  15 VLPFLgvymTAHLKFSIENTGIVLSFFGIGSVIGSWLGGFITDRIGEYKVQYLSLLLSVpLFCLIPLFKTEASVALIILL 94
Cdd:cd17331    22 VLPYL----TKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSA-LSYLLLAFASSVPMLFLSRL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  95 QSIVSDSFrPANSVAITKYAKPENitRAFSLNRMAVN--LGFSIGPALGGILS-AISYDFLFYSNALAALLAGLIYIRFF 171
Cdd:cd17331    97 PSVFMHAM-QAAQMVVTDLTDPGE--RAAALGRLGLSygIGMVVGSFLGGLLTkKFGEQAAALVAAVGSLLSIVLVILLI 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 172 YKRNKLAKIKAKKvqevmEIKKENSPYSDGKFLIYCFFCMLFSICFFQLF---------STLTIFYKDTAHLSQQSIGYI 242
Cdd:cd17331   174 PSNTKSKREKEAK-----ESASPPSVFNLKEILRLLRLPGVAFLLLVKLLsglpigmfqSMFSLVAMDFFGLTPEENGYL 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 243 LGYSGFLVVLLEMGLVQIAEKYF---TLARTMFLGTFICGLSYAMLGFDHSILTLIVSMSLlsAGEIWALPFMSTITALR 319
Cdd:cd17331   249 MSYAGVLGMVVQGLLVGPLTKRFgerSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVI--GGSVLYTVITSLLTKAV 326

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1494293610 320 SgKNNKGAYMGLNGISFSIAFIVTPYLGTLIAEKFGFNILW-IGTGILATMIAIGF 374
Cdd:cd17331   327 P-PEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGlLGAAINGLLTVYLL 381
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 15-376 1.83e-09

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 58.80  E-value: 1.83e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  15 VLPFLGVYMTAHLKFSIENTGIVLSFFGIGSVIGSWLGGFITDRIGEYKVqylsLLLSVPLFCLIPLFKTEASVALIILL 94
Cdd:cd17388    21 VLPTLLREFVGDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPV----LLLSLAGAALDYLLMAFAPTLWWLYL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  95 QSIVSD----SFRPANSVaITKYAKPENITRAFSLNRMAVNLGFSIGPALGGILSAIS--YDFLFysnALAALLAGLIYI 168
Cdd:cd17388    97 GRIIAGitgaTGAVAAAY-IADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISprAPFLV---AAGLNGLNFLLG 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 169 RFFYKRNKlakikaKKVQEVMEIKKENSPYSDGKFL-----IYCFFCMLFSICFFQ--LFSTLTIFYKDTAHLSQQSIGY 241
Cdd:cd17388   173 LFVLPESL------PPERRRAFRWRRANPFGSLRWLtgfpgLLGLLAVFFLIQLIGqvPATTWVLFTEDRFDWSPTMVGL 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 242 ILGYSGFLVVLLEMGLVQIAEKYFTLARTMFLGTFICGLSYAMLGFDHSILTLIVSMSLLSAGEIwALPFMSTITALRSG 321
Cdd:cd17388   247 SLAVFGLLHALFQAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALGGI-AGPALQGLLSRQVP 325

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1494293610 322 KNNKGAYMGLNGISFSIAFIVTPYLGTLIAEKFGFN---ILWIGTGILATMIAIGFYF 376
Cdd:cd17388   326 ENEQGELQGVLTSLTSLTSIIGPLLFTGIFAASPATwpgLAWIIGAALYLICLVLAYR 383
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
1-377 1.56e-08

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 56.04  E-value: 1.56e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610   1 MLALVMLINRSGSMVLPFLGVYMTAHLKFSIENTGIVLSFFGIGSVIGSWLGGFITDRIGEYKVQYLSLLLSVPLFCLIP 80
Cdd:COG2223     9 LATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLA 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  81 LFKTEASVALIILLQSIVSDSFRPANSVAITKYAKPENITRAFSLNRMAVNLGFSIGPALGG-ILSAISYDFLFYSNALA 159
Cdd:COG2223    89 LAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPlLIAAFGWRNAFLILGIL 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 160 ALLAGLIYIRFFYKRNKLAKIKAKKvqevmEIKKENSPYSDGKFLIYCFFCMLFSICFFQLFSTLTIFYKDTAHLSQQSI 239
Cdd:COG2223   169 LLVVAVLAWLFLRDPPAGAAAAAKA-----SLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATA 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 240 GYILGYSGFLVVLLEMGLVQIAEKyFTLARTMFLGTFICGLSYAMLGF-DHSILTLIVSMSLLSAGEIWALPFMSTITAL 318
Cdd:COG2223   244 GLLAALFALLGALGRPLGGWLSDR-IGGRRVLLIVFALMALGLLLLALaLGSLWLFLVLFLLLGLALGGGNGAVFALVPD 322

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 319 RSGKNNKGAYMGLNGISFSIAFIVTPYLGTLIAEKFG-FNILWIGTGILATMIAIGFYFI 377
Cdd:COG2223   323 IFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLL 382
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 1-155 2.46e-08

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 55.35  E-value: 2.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610   1 MLALVMLINRSGSMVLPFLGVYM------TAHLKFSienTGIVLSFFGIGSVIGSWLGGFITDRIGEYKVQYLSLLLSVP 74
Cdd:cd17391   206 LFVTTFIIQLANQSIEPILTLYIrqlmgdASNLAFI---SGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASAL 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  75 LFCLIPLFKTEASVALIILLQSIVSDSFRPANSVAITKYAKPENITRAFSLNRMAVNLGFSIGPALGGILSA-ISYDFLF 153
Cdd:cd17391   283 LYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAhFGYRAVF 362


                  ..
gi 1494293610 154 YS 155
Cdd:cd17391   363 VV 364
MFS_1 pfam07690
Major Facilitator Superfamily;
203-379 3.43e-08

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 54.73  E-value: 3.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 203 FLIYCFFCMLFSIcffqLFSTLTIFYKDTAHLSQQSIGYILGYSGFLVVLLEMGLVQIAEKyFTLARTMFLGTFICGLSY 282
Cdd:pfam07690   2 FLAAFLAALGRSL----LGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDR-FGRRRVLLIGLLLFALGL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 283 AMLGFDHSILTLIVSMSLLSAGEIWALPFMSTITALRSGKNNKGAYMGLNGISFSIAFIVTPYLGTLIAEKFGFNILWIG 362
Cdd:pfam07690  77 LLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLI 156

                         170
                  ....*....|....*..
gi 1494293610 363 TGILATMIAIGFYFIVP 379
Cdd:pfam07690 157 LAILSLLAAVLLLLPRP 173
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 269-379 6.82e-08

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 53.75  E-value: 6.82e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 269 RTMFLGTFICGLSYAMLGFDHSILTLIVSMSLLSAGEIWALPFMSTITALRSGKNNKGAYMGLNGISFSIAFIVTPYLGT 348
Cdd:cd17489    62 RLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGL 141

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1494293610 349 LIAEKFGFNILWIGTGILAtMIAIGFYFIVP 379
Cdd:cd17489   142 FLYQHLGFAVLFIVAAVLA-LLALLLVFLVK 171
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 1-151 9.89e-08

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 53.58  E-value: 9.89e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610   1 MLALVMLINRSGSMVLPFLGVYMTAHLKFSIENTGIVLSFFGIGSVIGSWLGGFITDR-IGEYKVQYLSLLLSVPLFCLI 79
Cdd:cd06174   208 LLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALL 287

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1494293610  80 PLFKTEASVALIILLQSIVSDSFRPANSVAITKYAKPENITRAFSLNRMAVNLGFSIGPALGGILSAISYDF 151
Cdd:cd06174   288 LLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGL 359
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
6-357 1.01e-07

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 53.75  E-value: 1.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610   6 MLINRSGSMVLPFLGVYMTAHLKFSIENTGIVLSFFGIGSVIGSWLGGFITD----RIGEYK----VQYLSLLLSVPLFC 77
Cdd:COG2211    20 LGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDrtrtRWGRRRpwilIGAIPLALSFVLLF 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  78 LIPLFKTEASV----ALIILLQSIVSDSFRPANSVAITKYAKPENITRAFSLNRMAVNLGFSIGPALGGILSAISYD--- 150
Cdd:COG2211   100 TAPDLSPTGKLiyalVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGdaa 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 151 ---FLFYSNALAALLAGLIYIRFFYKRNKLAKIKAKKVQEVMEIKKENSPysdgkFLIYCFFCMLFSICFFQLFSTLTIF 227
Cdd:COG2211   180 lgyRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESLKALLKNRP-----FLLLLLAYLLFFLALALVAALLLYY 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 228 YKDTAHLSQQSIGYILGySGFLVVLLEMGLVQIAEKYFTLARTMFLGTFICGLSYAMLGF--DHSILTLIVSMSLLSAGE 305
Cdd:COG2211   255 FKYVLGLSAALVGLLLA-LYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFlgPGNLWLLLVLAALAGIGL 333

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1494293610 306 ------IWA-LPFMSTITALRSGKNNKGAYMGLNGISFSIAFIVTPYLGTLIAEKFGFN 357
Cdd:COG2211   334 gailvlPWAmLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYV 392
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 1-147 1.49e-07

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 52.94  E-value: 1.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610   1 MLALVMLINRSGSMVLPFLGVYMTaHLKFSIENTGIVLSFFGIGSVIGSWLGGFITDRIGEYKVQYLSLLLSVPLFCLIP 80
Cdd:cd17478   200 LLIIVFLRSWVLSSLTTFLPFYLV-QRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFL 278

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1494293610  81 LFKTEASVALIILLQSIVSDSFrpANSVAITKYAKPENITRAFSLnrmavNLGFSIGpaLGGILSAI 147
Cdd:cd17478   279 LTPGIWSYILLVLAGFLLFASF--PVTVVLAQELLPGNVGLASGL-----MMGLSFG--LGGIGAPV 336
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 6-374 2.32e-07

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 52.24  E-value: 2.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610   6 MLINRSGSMV---LPFLGVYMTAHLKFSIENTGIVLSFFGIGSVIGSWLGGFITDRIGEYKVQYLSLLLSVPLFCLIPLF 82
Cdd:cd17475     2 TLAQAAASLVaqgIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  83 KTEASVALIILLQSIVSDSFRPANSVAITKYAKPENITRAFSLNRMAVNLGFSIGPA-LGGILSAISYDFLFYSNALAAL 161
Cdd:cd17475    82 GSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAAlLPPLALHYGWRAAFVVAGLVSI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 162 LAGLIYIRFFYKRNKLAKIKAKKVQEVMEIKkenSPYSDGKFLIYCFFCMLfsICFFQlFSTLT---IFYKDTAHLSQQS 238
Cdd:cd17475   162 LAAVLFWLFYREPPAASAATESASTLLRSLK---EVLRNRDVWLIAIAGAL--LVAPQ-FALLTfllLFLHDHLGLSVVA 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 239 IGYILGYSGFLVVLLEMGLVQIAEKYFTLAR--TMFLGTFICGLSYAMLGF--DHSILTLIVS-MSLLSAGEI-WALPFM 312
Cdd:cd17475   236 AGALLAVAQLGGALGRIGLGRVSDRVFGGRRrpVLVITAAIAAAALLVLSLlsPGTPLWLLVLlLILLGLFAIgWNGLYL 315

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1494293610 313 STITALrSGKNNKGAYMGL-NGISFSIAFIVTPYLGTLIAEKFGFNILWIgtgILATMIAIGF 374
Cdd:cd17475   316 TLVAES-AGPEQAGTALGLaNTINFIGIAIGPPLFGLLVDATHSYAPAWL---ALALLLVLAA 374
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
196-379 2.82e-07

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 51.90  E-value: 2.82e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 196 SPYSDGKFLIYCFFCMLFSICFFQLFSTLTIFYKDTAHLSQQSIGYILGYSGFLVVLLEMGLVQIAEKyFTLARTMFLGT 275
Cdd:COG2814     4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADR-FGRRRVLLLGL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 276 FICGLSYAMLGFDHSILTLIVSMSLLSAGEIWALPFMSTITALRSGKNNKGAYMGLNGISFSIAFIVTPYLGTLIAEKFG 355
Cdd:COG2814    83 LLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162

                         170       180
                  ....*....|....*....|....
gi 1494293610 356 FNILWIGTGILATMIAIGFYFIVP 379
Cdd:COG2814   163 WRWVFLVNAVLALLALLLLLRLLP 186
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 23-374 3.83e-07

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 51.40  E-value: 3.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  23 MTAHLKFSIENTGIVLSFFGIGSVIGSWLGGFITDRIGEYKVQYLSLLLSVPLFCLIPLFKTEASVALIILLQSIVSDSF 102
Cdd:cd17324    25 IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGF 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 103 RPANSVAITKYAKPENITRAFSLNRMAVNLGFSIGPALGGILS-AISYDFLFYSNALAALLAGLIYIRFfykrnkLAKIK 181
Cdd:cd17324   105 WAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGqLLGWRAAFLAIAVLALLAALLLWRL------LPSLP 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 182 AKKVQEVMEIKKENSPYSDGKFLIYCFFCMLFSICFFQLFSTLTIFYKDTAHLSQQSIGYILGYSGFLVVLLEMGLVQIA 261
Cdd:cd17324   179 PKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLA 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 262 EKYFTLaRTMFLGTFICGLSYAMLGFDHSILTLIVSMSLLSAGeIWALPFMSTITALRSGKNNKGAYMGLNGISFSIAFI 341
Cdd:cd17324   259 DRGGRR-ALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLG-FFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGA 336

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1494293610 342 VTPYLGTLIAEKFGfnilWIGTGIL-ATMIAIGF 374
Cdd:cd17324   337 LGAALGGLVLDHGG----WAGVGWVgAALLLLAL 366
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 13-352 1.03e-06

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 50.30  E-value: 1.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  13 SMVLPFLGVYMTAhLKFSIENTGIVLSFFGIGSVIGSWLGGFITDRIGEYKVQYLSLLLSVPLFCLIPLfkteASVALII 92
Cdd:cd17390    13 SMILPLLSTHIRS-LGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGF----STSLALL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  93 LLQSIVSDSFRPANSVA---ITKYAKPENITRAFSLNRMAVNLGFSIGPALGGILSAISYDFLFYSNALAALLAGLIYIR 169
Cdd:cd17390    88 FLSRIPLGIFKHTQSLCkayLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDGGFYYVALLCSAIFILNAGLV 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 170 FFYkrnklakikAKKVQEVMEIKkenspysdgkfliycfFCMLFSICFFqlFSTLTIFYKDTAHLSQQSIGYILGYSGFL 249
Cdd:cd17390   168 WFL---------LSKLWDLLLVR----------------FLMGFSVLLF--RSNFSLYLEERFDLSPKTIGYLISYSGVL 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 250 VVLLEMGLVQIAEKYFTLARTMFLGTFIC-GLSYAMLGFDHSILTLIVSMSLLSAGEIWALPFMSTITALRSGKNNKGAY 328
Cdd:cd17390   221 GALSGFLVGRILKLYKNNEYLLLLHSFILlALSLLGLALAPSIWLLVLCLTPLSISSAVLRTCSTSLLLSRGKSKERGTL 300

                         330       340
                  ....*....|....*....|....
gi 1494293610 329 MGLNGISFSIAFIVTPYLGTLIAE 352
Cdd:cd17390   301 LGVGQSVTSLARILAPLLSGLLQE 324
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 2-296 3.53e-06

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 48.70  E-value: 3.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610   2 LALVMLINRSGSMVLPFLGVYMTAHLKFSIENTGIVLSFFGIGSV-IGSWLGGFITDRIGEYKVQYLSLLLSVPLFCLIP 80
Cdd:cd17471     2 LLATLLTGLAGAFVLPYLSLFLTEELGASPLQIGIFMTLSALSGIvVSQWLGRLSDRGGDRKPLILLALLAGALGYLLFA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  81 LFKTEASVALI-ILLQSIVSDSFrP---ANSVAITKYAKPENITRAFSLNRMAVNLGFSIGPALGG-ILSAISYDFLFYS 155
Cdd:cd17471    82 FLRNYWVLLLVgVVLLSLGAAAF-PqlfALAREYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFlLLDVLGFTGLFLL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 156 NALAALLAGLIYIRFFykrnklaKIKAKKVQEVMEIKKENSPYSDGKFLIYCFFCMLFSICFFQLFSTLTIFYKDTAHLS 235
Cdd:cd17471   161 AALLYLVVALLVLFLL-------PSVKPPAQKATPASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGS 233

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1494293610 236 QQSIGYILGYSGFLVVLLEMGLVQIAEKyFTLARTMFLGTFICGLSYAMLGFDHSILTLIV 296
Cdd:cd17471   234 ESWVGLLFGLAAALEIPIMLLAGLLAKR-FGKRRLLLAGFLAGVLFYLGLALATSLWQLIA 293
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 269-379 5.15e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 47.96  E-value: 5.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 269 RTMFLGTFICGLSYAMLGFDHSILTLIVSMSLLSAGEIWALPFMSTITALRSGKNNKGAYMGLNGISFSIAFIVTPYLGT 348
Cdd:cd17325    62 RLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGG 141

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1494293610 349 LIAEKFGFNILWIGTGILATMIAIGFYFIVP 379
Cdd:cd17325   142 LLADALGYRAPFLVCAALALLALVLALLLLP 172
MFS_DtpA_like cd17346
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ...
 19-380 5.28e-06

Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340904 [Multi-domain]  Cd Length: 399  Bit Score: 47.96  E-value: 5.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  19 LGVYMTAHL--KFSIENTGIVLSFFGIGSVIGSWLGGFITDRI-GEYKVQYLSLLLSVPLFCLIPLFKTEASVALIILLQ 95
Cdd:cd17346    25 LILYLTAQLgdGFSEADAASIYGAYTALVYLTPIIGGWLADKVlGARRTVFIGGILMALGYLLLALSPFSVSMLYLGLAL 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  96 SIVSDSFRPANSVAITKYAKPENITR---AFSLNRMAVNLGFSIGPALGGILS-AISYDFLFYSNALAALLAGLIyirFF 171
Cdd:cd17346   105 IIVGNGLFKPNISSLVGKLYDENDPRrdsGFSIFYMGINLGAFLAPLLCGTLGdNYGYHYGFGLAAVGMLLGLLI---FL 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 172 YKRNKLAKIKAKKVqevmeikkenspysdgkFLIYCFFCMLFSICFFQLFSTLTIFYKDTAHLSQQSI----GYILGYSG 247
Cdd:cd17346   182 LGRKKLLERKKMLA-----------------IIILFLFAVVFWAIYEQAGTSLALFADENVDRLLGGFtippSWFQSLNP 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 248 FLVVLLEMGLVQI------AEKYFTLARTMFLGTFICGLSYAMLGFDHSILTLIVSMS---------LLSAGEIWALPF- 311
Cdd:cd17346   245 LFIILLAPILAALwtklgkRGKDPSIPTKFALGLLLLGLSFLLMVLAASFAGGSGKVSalwlvlsyfLQTLGELCLSPVg 324

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1494293610 312 MSTITALrSGKNNKGAYMGLNGISFSIAFIVTPYLGTLIAE-------KFGFNILWIGTGILATMIAIGFYFIVPW 380
Cdd:cd17346   325 LSMITKL-APAKFAGFMMGLWFLASALGNILAGYLAGFYAQpkdplasALVYTDYFGLIGVIALVAGIILLLLAKK 399
PRK10054 PRK10054
efflux MFS transporter YdeE;
3-154 9.21e-06

efflux MFS transporter YdeE;


Pssm-ID: 182213  Cd Length: 395  Bit Score: 47.43  E-value: 9.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610   3 ALVMLINRSGSmvLPFLGVYMTAHLKFSIENTGIVLSFFGIGSVIGSWLGGFITDRIGEYKVQYLSLLLSVPLFCLIPLF 82
Cdd:PRK10054   16 SLLLTIGRGAT--LPFMTIYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLV 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1494293610  83 KteaSVALIILLQSIVSDSFRPANSVAITKYAK---PENITRAFSLNRMAVNLGFSIGPALGGILSAISYDFLFY 154
Cdd:PRK10054   94 N---NVTLVVLFFALINCAYSVFSTVLKAWFADnlsSTSKTKIFSLNYTMLNIGWTVGPPLGTLLVMQSINLPFW 165
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 4-144 1.13e-05

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 47.19  E-value: 1.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610   4 LVMLINRSGSMVLPFL-GVYMTAHLKFSIENTGIVLSFFGIGSVIGSWLGGFITDRIGEYKVQYLSLLLSVPLFCLIPLF 82
Cdd:cd17503   185 LLSFLLGLGLFGAMFLlPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFL 264

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1494293610  83 KTEASVALIILLQSI----VSDSFRPANSVAItKYAKPENITRAFSLNRMAVNLGFSIGPALGGIL 144
Cdd:cd17503   265 TPDTSLWLIILPLFIrglgMGLVFMPLNTLAL-NSLPPEQIGDATALFNTIRQLGGSIGTALLATL 329
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
204-372 1.19e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 46.79  E-value: 1.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 204 LIYCFFCMLFSICFFQLFSTLTIFYKDTAHLSQQSIGYILGYSGFLVVLLEMGLVQIAEKYFTlARTMFLGTFICGLSYA 283
Cdd:COG2271    12 LALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGR-RRVLAIGLLLWGLATL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 284 MLGFDHSILTLIVSMSLLSAGEIWALPFMSTITALRSGKNNKGAYMGLNGISFSIAFIVTPYLGTLIAEKFGFNILWIGT 363
Cdd:COG2271    91 LFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLIL 170


                  ....*....
gi 1494293610 364 GILATMIAI 372
Cdd:COG2271   171 GLPGLLLAL 179
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 1-377 1.36e-05

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 46.79  E-value: 1.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610   1 MLALVMLINRSGSMVLPFLGVYMTAHLKFSIENTGIVLSFFGIGSVIGSWLGGFITDRIGEYKVqYLSLLLSVPLFCLIP 80
Cdd:cd17319     7 LLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKV-LAVSMLLWSLFTALT 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  81 LFKTEASVALII-LLQSIVSDSFRPANSVAITKYAKPENITRAFSLNRMAVNLGFSIGPALGG-ILSAISYDFLFYSNAL 158
Cdd:cd17319    86 GFATSLTSLYVLrFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGwLLLLFGWRWAFIIEGL 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 159 AALLAGLIYIRFFykrnklakikakkvqevmeikkenspysdGKFLIYCFFCMLFSICFFQLFSTLTIFYKDTAHLSQQS 238
Cdd:cd17319   166 LGLLLAVLWWFYL-----------------------------RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQ 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 239 IGYILGYSGFLVVLLEMGLVQIAEKYFTLARTM--FLGTFICGLSYAMLGFDHSILTLIVSMSLLSAGEIWALPFMSTIT 316
Cdd:cd17319   217 VGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLviIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLP 296

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1494293610 317 ALRSGKNNKGAYMGLNGISFSIAFIVTPYL-GTLIAEKFGFNILWIGTGILATMIAIGFYFI 377
Cdd:cd17319   297 ADLLPGEAAATAGGLINSGGNLGGFVAPLLiGYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 35-372 1.43e-05

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 46.82  E-value: 1.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  35 GIVLSFFGIGSVIGSWLGGFITDRIGEYK----VQYLSLLLSVPLFCLIPLFKTEasVALIILLQSIVSDsFRPANSVAI 110
Cdd:cd17326    39 GWVVAAYSLGQLVFSPVFGYWSNKTSSVKepliVSILIAIVGNILYALAEYFPSN--RKYVMLVARFLIG-VGAGNVAVL 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 111 TKYA----KPENITRAFSLNRMAVNLGFSIGPALGGILSAISYDFLFYSNA-------------LAALLAGLIYIRFFYK 173
Cdd:cd17326   116 RAYVaaasTLKDRTRAMAVISAAQALGFIVGPALQAAFTPIGYPGYVIGIKlrfnmytapawlmAILGIINIILILFFFK 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 174 rnklakikakkvqEVmeikkenspysdgkFLIYCFFCMLFSICFFQlfSTLTIFYKDTAHLSQQSI----GYILGYSGFL 249
Cdd:cd17326   196 -------------EV--------------VCIFLFFVVLFIFANLE--TIGTPLTMDMYGWTREEAvlynGIILAVSGVL 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 250 VVLLEMGLVQIAEKYFTLARTMFLGTFICGLSYAMLGFDHSILTLIVSMsllsageiwALPFMST-ITALRS---GKNNK 325
Cdd:cd17326   247 SVLVFLLFKFLSLGLIDERKILLGGLILFFLGFVVTLPWGITGVILFGL---------GYPIGNVmLYTLYSkilGPKPQ 317

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1494293610 326 GAYMGLNGISFSIAFIVTPYLGTLIAEKFGFNILWIGTGILATMIAI 372
Cdd:cd17326   318 GTMQGVLTASGSLARTLGPIFVTAIYTHFGPRWTWIITLGLLLLAII 364
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 1-155 2.27e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 46.03  E-value: 2.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610   1 MLALVMLINRSGSMVLPFLGVYMTAHLKFSIENTGIVLSFFGIGSVIGSWL-GGFITDRIGEYKVQYLSLLLSVPLFCLI 79
Cdd:cd17330   179 LLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLlIPRLAKRLGERKLLRLGLLLAIIGLLLL 258

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1494293610  80 PLFKTEASVALIILLQSIVSDSFRPANSVAITKYAKPENITRAFSLNRMAVNLGFSIGPALGGILSAISYDFLFYS 155
Cdd:cd17330   259 PFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFL 334
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
204-379 3.03e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 45.64  E-value: 3.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 204 LIYCFFCMLFSICFFQLFSTLTIFYKDTAHLSQQSIGYILGYSGFLVVLLEMGLVQIAEKYFTlARTMFLGTFICGLSYA 283
Cdd:COG2223     7 LLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGP-RRVLLIGLLLLGIGLL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 284 MLGFDHSILTLIVSMSLLSAGEiwALPFMSTITALRS--GKNNKGAYMGLNGISFSIAFIVTPYLGTLIAEKFGFNILWI 361
Cdd:COG2223    86 LLALAVSYWLLLLLGLLLGIGG--GGSFAVGIALVSKwfPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFL 163

                         170
                  ....*....|....*...
gi 1494293610 362 GTGILATMIAIGFYFIVP 379
Cdd:COG2223   164 ILGILLLVVAVLAWLFLR 181
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 1-146 4.88e-05

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 44.91  E-value: 4.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610   1 MLALVMLINRSGSMVLPFLGVYMTAHLKFSIENTGIVLSFFGIGSVIGSWLGGFITDRIGEYKVQYLSLLLSVPLFCLIP 80
Cdd:cd06173   213 LLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLG 292

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1494293610  81 LFKTEASVALIILLQSIVSDSFRPANSVAITKYAKPENITRAFSLNRMAVNLGFSIGPALGGILSA 146
Cdd:cd06173   293 LSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLAD 358
PRK03893 PRK03893
putative sialic acid transporter; Provisional
 18-147 5.21e-05

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 45.07  E-value: 5.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  18 FLGVYMTAHLKFSIENTGIVLSFFGIGSVIGSWLGGFITDRIGEYKVQYLSLLLSvpLFCLIPLFKTEASVALIILLQSI 97
Cdd:PRK03893  297 LLPTYLKTDLGYDPHTVANVLFFSGFGAAVGCCVGGFLGDWLGTRKAYVCSLLIS--QLLIIPVFAIGGANVWVLGLLLF 374

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1494293610  98 VSDSFRPANSVAITKYakpenITRAFSLNRMAVNLGFS--IGpALGGILSAI 147
Cdd:PRK03893  375 FQQMLGQGISGLLPKL-----IGGYFDTEQRAAGLGFTynVG-ALGGALAPI 420
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 2-376 6.14e-05

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 44.84  E-value: 6.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610   2 LALVMLINRSGS-MVLPFLGVYMTAhLKFSIENTGIVLSFFGIGSVIGSWLGGFITDRIGEYK----VQYLSLLLSVPLF 76
Cdd:cd17370     4 LGLVSLFADISYeMARSILPLFLVV-LGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKplviLGYGLSALAKPLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  77 cliPLFKTEASVALIILLQSIvSDSFR-PANSVAITKYAKPENITRAFSLNRMAVNLGFSIGPALGGIL---SAISYDFL 152
Cdd:cd17370    83 ---ALAGSWQLVLLLRILERL-GKGIRtPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLlylLGGNYRTI 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 153 FYSnaLAALLAGLIYIRFFYKRNKLAKIKAKKVQEVMEIKKenspySDGKFLIYCFFCMLFSICFFqlFSTLTIFYKDTA 232
Cdd:cd17370   159 FLL--AAIPALLALLILLFVVKEYPRPPKLRKKSKKTSLKK-----LPKAFWLYLLAVALFALGNF--SFAFLILRAQEL 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 233 HLSQQSIgyILGYSGFLVVLLEMGLV--QIAEKYfTLARTMFLGTFICGLSYAMLGFDHSILTLIVSMSLLSAGEIWALP 310
Cdd:cd17370   230 GLSAALI--PLLYALFNLVYALAAYPagRLSDRI-GRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQES 306

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1494293610 311 FMSTITALRSGKNNKGAYMGLNGISFSIAFIVTPYLGTLIAEKFGFNILwIGTGILATMIAIGFYF 376
Cdd:cd17370   307 IERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAA-FLFSAVLALIALLLLL 371
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 2-149 7.24e-05

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 44.47  E-value: 7.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610   2 LALVMLINRSGSMVLPFLGVYMTAHLKFSIENTGIVLSFFGIGSVIGSWLGGFITDRIGEYKVQYLSLLLSVPLFCLIPL 81
Cdd:cd17321   174 VLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLAL 253

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1494293610  82 FKTEASVALII---LLQSIVSDSFRPANSVAITKYAKPENITRAFSLNRMAVNLGFSIGPALGGILSAISY 149
Cdd:cd17321   254 LGADSSVWLLLpglVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAGL 324
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 18-154 1.41e-04

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 43.70  E-value: 1.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  18 FLGVYMTAHlKFSIENTGIVLSFFGIGSVIGSWLGGFITDR--IGEYKVQYLSLLLSVPLFCLIPLFKTEASVALIILLQ 95
Cdd:cd17352   205 YLPSYAKSL-GIDESDAAFLLSIIGISDIVGRILLGLLADKprIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLF 283

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1494293610  96 SIVSDSFRPANSVAITKYAKPENITRAFSLNRMAVNLGFSIGPALGGILSAI--SYDFLFY 154
Cdd:cd17352   284 GFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYtgDYDAAFY 344
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 2-374 1.62e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 43.31  E-value: 1.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610   2 LALVMLINRSGSMVLPFLGVYMTAHLKFSIENTGIVLSFFGIGSVIGSWLGGFITDRIGEYKVQYLSLLLSVPLFCLIPL 81
Cdd:cd17478     1 LSLGHFLNDFYQGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  82 FKTEASVALIILLQSIVSDSFRPANSVAITKYAkPENITRAFSLNRMAVNLGFSIGPALGGILSAISYDFLFYSNALAAL 161
Cdd:cd17478    81 APNYWLLLLLVALAGIGSAAFHPEGARLASQAA-GGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 162 LAGLIYIRFFYKRNKLAKIKAKKVQEVMEIKKENSpysdGKFLIYCFFCMLFSICFFQLFSTLTIFYKDTahlsqqsiGY 241
Cdd:cd17478   160 LAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVW----RALLLLLIIVFLRSWVLSSLTTFLPFYLVQR--------GY 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 242 ILGYSGFLVVLLEMG------LVQIAEKYFTLARTMFLGTFICGLSYAMLGFDHSILTLIVsmsLLSAGEIWALPFMSTI 315
Cdd:cd17478   228 SLVFAGLLLSLFLFAgaigtlIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYIL---LVLAGFLLFASFPVTV 304

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1494293610 316 T-ALRSGKNNKGAYMGL-NGISFSIAFIVTPYLGtLIAEKFGFNI-LWIGTGILATMIAIGF 374
Cdd:cd17478   305 VlAQELLPGNVGLASGLmMGLSFGLGGIGAPVLG-ALADAFGLESvLLILALLPLLGALLAF 365
PRK11646 PRK11646
multidrug efflux MFS transporter MdtH;
51-338 2.16e-04

multidrug efflux MFS transporter MdtH;


Pssm-ID: 183255  Cd Length: 400  Bit Score: 43.12  E-value: 2.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  51 LGGFITDRIGEYKVQYLSLLLSVPLFCLIPLFKTEASVALIILLQSIVSDSFRPANSVAITKYAKPENITRAFSLNRMAV 130
Cdd:PRK11646   65 FGGAIADRFGAKPMIVTGMLMRAAGFATMAIAHEPWLLWLSCILSGLGGTLFDPPRTALVIKLIRPHQRGRFFSLLMMQD 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 131 NLGFSIGPALGGILsaISYDF-LFYSNALAALLAGLIYIRFFYKRNKLAKIKAKKVQEVMEIKKenspysDGKFLIYCFF 209
Cdd:PRK11646  145 SAGAVIGALLGSWL--LQYDFrLVCATGAVLFVLAAAFNAWLLPAYKLSTVRTPVREGMTRVLR------DKRFVTYVLT 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 210 CMLFSICFFQLFSTLTIFYKDTAHlSQQSIGYILGYSGFLVVLLEMGLVQIAEKYFTLARTMFLGTFICGLSYAMLGFDH 289
Cdd:PRK11646  217 LTGYYMLAVQVMLMLPIMVNDIAG-SPSAVKWMYAIEACLSLTLLYPIARWSEKRFRLEHRLMAGLLIMSLSMFPIGMVS 295

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1494293610 290 SILTLIVSMSLLSAGEIWALPFMSTITALRSGKNNKGAYMGLNGISFSI 338
Cdd:PRK11646  296 NLQQLFTLICLFYIGSIIAEPARETLSASLADARARGSYMGFSRLGLAL 344
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
22-372 2.87e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 42.53  E-value: 2.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  22 YMTAHLKFSIENTGIVLSFFGIGSVIGSWLGGFITDRIGEYKVQYLSLLLSVPLFCLIPLFKTEASVALIILLQSIVSDS 101
Cdd:COG0738    33 ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGL 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 102 FRPANSVAITKYakpENITRAFSLNRM-AVN-LGFSIGPALGGILSAISYDFLFYSNALAALLAGLIYIrFFYKRNKLAK 179
Cdd:COG0738   113 LDVAANPYVAAL---GPETAASRLNLLhAFFsLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLA-LLFLRSKLPE 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 180 IKAKKVQEVMEIKKENSPYSDGKFLIYCFFCMLFSICFFQLFSTLTIFYKDTAHLSQQSIGYILGYSGFLVVLLEMGLVQ 259
Cdd:COG0738   189 IEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGF 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 260 IAeKYFTLARTMFLGTFICGLSYAMLGFDHSILTLIVSMSLLSAGeiwALPFMSTI--TALRSGKNNKGAYMGLNGISFS 337
Cdd:COG0738   269 LL-KRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLG---LSLMFPTIfsLALDGLGKRTAAAVSAVLIMGI 344

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1494293610 338 IAFIVTPYLGTLIAEKFGFNILWIGTGILATMIAI 372
Cdd:COG0738   345 VGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILL 379
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 23-146 3.38e-04

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 42.11  E-value: 3.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  23 MTAHLKFSIENTGIVLSFFGIGSVIGSWLGGFITDRIGEYKVQYLSLLLSVPLFCLIPLFKTEASVALIILLQSIVSDSF 102
Cdd:COG0477    40 IAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGL 119

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1494293610 103 RPANSVAITKYAKPENITRAFSLNRMAVNLGFSIGPALGGILSA 146
Cdd:COG0477   120 MPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVA 163
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
1-150 4.37e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 42.20  E-value: 4.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610   1 MLALVMLINRSGSMVLPFLGVYMTAHLKFSIENTGIVLSFFGIGSVIGSWLGGFITDRIGEYKVQYLSLLLSVpLFCLIP 80
Cdd:COG2211   233 LLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAA-LGLLLL 311

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  81 LFKTEASVALIILLQSIVSDSFRPANSVA------ITKYAKPENITRA----FSLNRMAVNLGFSIGPALGG-ILSAISY 149
Cdd:COG2211   312 FFLGPGNLWLLLVLAALAGIGLGAILVLPwamladVVDYDEWKTGRRReglyFGIFTFAIKLGQALAGALAGlLLALFGY 391


                  .
gi 1494293610 150 D 150
Cdd:COG2211   392 V 392
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 29-154 9.44e-04

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 41.07  E-value: 9.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  29 FSIENTGIVLSFFGIGSVIGSWLGGFITDRIGEYKVQYLSLLLSVPLFCLIPLFKTEASVALIIL--LQSIVSDSFRPAN 106
Cdd:cd17318    53 WSEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLriLQGLAQGVTFPAM 132

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1494293610 107 SVAITKYAKPENITRAFSLNRMAVNLGFSIGPALGGILSA-ISYDFLFY 154
Cdd:cd17318   133 HALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCEsLGWPSIFY 181
PTR2 COG3104
Dipeptide/tripeptide permease [Amino acid transport and metabolism];
19-383 1.80e-03

Dipeptide/tripeptide permease [Amino acid transport and metabolism];


Pssm-ID: 442338 [Multi-domain]  Cd Length: 479  Bit Score: 40.18  E-value: 1.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  19 LGVYMTAHLK-----FSIENTGIVLSFFGIGSVIGSWLGGFITDR-IGEYK-VQYLSLLLSVPLFCL-IPLFKTE--ASV 88
Cdd:COG3104    37 LVLYLTASLAdgglgLSEADAAAIYGAYTALVYLTPLLGGWLADRlLGQRRaILLGGILMALGHFLLaLPGGVTLfyLGL 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  89 ALIIL--------LQSIVSDSFRPANSvaitkyakpeNITRAFSLNRMAVNLGFSIGPALGGIL---------------- 144
Cdd:COG3104   117 ALIAVgnglfkpnISSLVGQLYDPGDP----------RRDAGFTIFYMGINIGAFLAPLLCGYLgekygwhygfgaaaig 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 145 ---------------------------------------------SAISYDFLFYSNALAALLAGLIYIRFFYKRNKLAK 179
Cdd:COG3104   187 mligliifllgrkylgdiglepdnplskkerliavalgalllvlvLAGLLSNANIANYLLYVIAIIAYFIFILRSKKLTK 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 180 IKAKKVqevmeikkenspysdGKFLIYCFFCMLFSICFFQLFSTLTIFYKDTAHLSqqsigyILGYS----------GFL 249
Cdd:COG3104   267 EERKRL---------------LAILILFLFSIVFWALYEQAGTSLNLFADRNVDRS------LFGFEippswfqslnPLF 325

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 250 VVLLEMGLVQIAEKY------FTLARTMFLGTFICGLSYAMLGF-------DH--SILTLIVSMSLLSAGEIWALPF-MS 313
Cdd:COG3104   326 IIILAPVFAALWTKLgkrgkePSTPTKFALGLLLLGLGFLVMALaallagaGGkvSPLWLVLAYLLLTIGELCLSPVgLS 405

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 314 TITALrSGKNNKGAYMGLNGISFSIAFIVTPYLGTLIAEkFGFNILWIGTGILATMIAIGFYFIVPWMLK 383
Cdd:COG3104   406 MITKL-APARFAGQMMGLWFLATALGNLLAGLLAGLYAV-PGYTAYFLLLGGIALVAGVVLLLLSPKLRR 473
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 13-144 2.27e-03

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 39.89  E-value: 2.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  13 SMVLPFLGVYMTAHLKFSIENTGIVLSFFGIGS-VIGSWLGGFITDRIGEYKVQYLSLLLSVPLFCLIPLFKTEASVALI 91
Cdd:cd17331   224 GMFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGmVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVL 303

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1494293610  92 ILLQSIVSDSFRPANSVAITKYAKPENITRAFSLNrMAVN-LGFSIGPALGGIL 144
Cdd:cd17331   304 LLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLS-HALFsLVRTVSPTIGGAL 356
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 206-379 3.18e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 39.33  E-value: 3.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 206 YCFFCMLFSICFFQLFSTLTIFYKDTaHLSQQSIGYILGYSGFLVVLLEMGLVQIAEKYFTlARTMFLGTFICGLSYAML 285
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSF-GLSASQLGLLFALFSLGYALLQPLAGLLADRFGR-RPVLLLGLLLFALGALLF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 286 GFDHSILTLIVSMSLLSAGEIWALPFMSTITALRSGKNNKGAYMGLNGISFSIAFIVTPYLGTLIAE--KFGFNILWIGT 363
Cdd:cd06174    79 AFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIA 158

                         170
                  ....*....|....*.
gi 1494293610 364 GILATMIAIGFYFIVP 379
Cdd:cd06174   159 AALALLAAILLLLVVP 174
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 2-145 3.37e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 39.08  E-value: 3.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610   2 LALVMLINRSGSMVLPFLGVYMTAHlKFSIENTGIVLSFFGIGSVIGSWLGGFITDRIGEYKVQYLSLLLSVPLFCLIPL 81
Cdd:cd17477     2 LLSVALLGLGSGLLLPLLSLRLERE-GVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1494293610  82 FKTEASVALIILLQSIVSDSFRPANSVAITKYAKPENITRAFSLNRMAVNLGFSIGPALGGILS 145
Cdd:cd17477    81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVG 144
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 15-93 3.43e-03

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 39.21  E-value: 3.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  15 VLPFLGVYMTAHLKFSIENTGIVLSFFGIGSVIGSWLGGFITDRIGEYKVQYLSLLLS---VPLFCLIPLFKTEASVALI 91
Cdd:cd17371   228 ITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSaisILLYFFLPLSPTLILILGF 307


                  ..
gi 1494293610  92 IL 93
Cdd:cd17371   308 PL 309
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 1-367 4.43e-03

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 38.71  E-value: 4.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610   1 MLALVMLINRSGSMVLPFLGvYMTAHLKFSIENTGIVLSFFGIGSVIGSWLGGFITDRIGEYKVQYLSLLLSVpLFCLIP 80
Cdd:cd17320     4 LALLVALGPLAIDMYLPALP-AIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFI-LASLLC 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  81 LFKTEASVALII-LLQSIVSDSFRPANSVAITKYAKPENITRAFSLNRMAVNLGFSIGPALGG-ILSAISYDFLFYSNAL 158
Cdd:cd17320    82 ALASSIEQLLIArFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGlLLLFFGWRAIFVFLAL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 159 AALLAGLIYIRFFYKRNKLAKIKaKKVQEVMEIKKEnsPYSDGKFLIYCFFCMLFSICFFQLFSTLTIFYKDTAHLSQQS 238
Cdd:cd17320   162 LGLLLLLLVLLFLPETLPEEKRK-PLLSSLLRAYKR--VLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQ 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 239 IGYILGYSGFLVVLLEMGLVQIAEKyFTLARTMFLGTFICGLSYAML-----GFDHSILTLIVSMSLLSAGEIWALPFMS 313
Cdd:cd17320   239 FGLLFALNAIALILGSLLNGRLVRR-FGPRRLLRLGLLLLLAAALVLllaalLGGLSLWPLVAPLFLIFFGFGLIFPNAT 317

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1494293610 314 TItALRSGKNNKGAYMGLNG-ISFSIAFIVTPYLGTLIAEKFG-FNILWIGTGILA 367
Cdd:cd17320   318 SL-ALEPFPHVAGTASALLGfLQFLIGALAGALVGLLPNGTALpMGLLILVLGLLA 372
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 13-147 4.91e-03

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 38.82  E-value: 4.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  13 SMVLPFLGVYMTAHLKFSIENTGIVLSFFGIGSVIGSWLGGFITDRIGEYKVQYLSLLLSVPLFCLIPLFKTEASVALII 92
Cdd:cd17371    15 LLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILR 94

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1494293610  93 LLQSIVSDSFRPANSVAITKYAKPENITRAFSLnrmaVNLGFSIGPALGGILSAI 147
Cdd:cd17371    95 ALAGLGFGGEWAAGAALMAEYVPARHRGKALGY----VQSGWAVGWLLATLLAAL 145
PRK05122 PRK05122
major facilitator superfamily transporter; Provisional
 212-379 4.96e-03

major facilitator superfamily transporter; Provisional


Pssm-ID: 235348 [Multi-domain]  Cd Length: 399  Bit Score: 38.71  E-value: 4.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 212 LFSICFFQLFSTLTIFYKdTAHLSqqsiGYI---LGYSGFLVvllemGLVqIAEKYF-TLA---------------RTMF 272
Cdd:PRK05122   17 IVSIVMFTFISYLTIGLP-LAVLP----GYVhdqLGFSAFLA-----GLV-ISLQYLaTLLsrphagryadtlgpkKAVV 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610 273 LGTFICGLS---YAMLGFDH-----SILTLIVSMSLLSAGEIWALPFMSTITALRSGKNNKGAYMGLNGISFSIAFIVTP 344
Cdd:PRK05122   86 FGLCGCALSgllYLLAGLLAawpvlSLLLLLLGRLLLGIGESLAGTGSILWGIGRVGALHTGRVISWNGIATYGALAIGA 165

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1494293610 345 YLGTLIAEKFGFNILWIGTGILAtmiAIGFYFIVP 379
Cdd:PRK05122  166 PLGVLLYHWGGLAGLGLLIMLLA---LLGLLLARP 197
MFS_3 pfam05977
Transmembrane secretion effector; This is a family of transport proteins. Members of this ...
 49-146 9.07e-03

Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.


Pssm-ID: 399164 [Multi-domain]  Cd Length: 523  Bit Score: 38.19  E-value: 9.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  49 SWLGGFITDRIGEYKVQY--LSLLLSVPLFCLIPLFKTEASVALII---LLQSIVSDSFRPANSVAITKYAKPENITRAF 123
Cdd:pfam05977  62 SIPAGALADNFDRRKIMLagQLLLALVSTLLTLLAGLGLLSPWLLLgltFLGGIGTALMDPAWQASVPELVPRRDLPAAV 141

                          90       100
                  ....*....|....*....|...
gi 1494293610 124 SLNRMAVNLGFSIGPALGGILSA 146
Cdd:pfam05977 142 ALNSVGYNIARSVGPALGGVLLA 164
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
 15-148 9.13e-03

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 37.82  E-value: 9.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494293610  15 VLPFLGVYMTAHLKFSIENTGIVLSFFGIGSVIGSWLGGFITDRIGEYKVQYLSLLLSVpLFCLIPLFKTEASVALIILL 94
Cdd:COG2270   257 VIAFAGIYAAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWI-VVCLAAYFLTTALAFWILGL 335

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1494293610  95 qsIVSDSFRPANSVAITKYAK---PENITRAFSLNRMAVNLGFSIGPALGGILSAIS 148
Cdd:COG2270   336 --LIGLVMGGIQALSRSLLARlipPGREAEFFGLYALSGKAASFLGPLLFGLVTQLT 390
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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