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Conserved domains on  [gi|149292723|gb|EDM42797|]
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AraC-family transcriptional regulatory protein [Yersinia pestis CA88-4125]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10219 super family cl32481
superoxide response transcriptional regulator SoxS;
6-108 1.72e-29

superoxide response transcriptional regulator SoxS;


The actual alignment was detected with superfamily member PRK10219:

Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 102.70  E-value: 1.72e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149292723   6 HLALVCALSKWVETHLGRVIYLEELAAYSGYSLWHMQKIFKDVTGVSLGKYIRERLLAGAVYQLRSSDSTIFDIALDFGF 85
Cdd:PRK10219   3 HQKIIQTLIAWIDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDLGY 82

                         90       100
                 ....*....|....*....|...
gi 149292723  86 GSQSHFTYMFRKHYGITPYDFRQ 108
Cdd:PRK10219  83 VSQQTFSRVFRRQFDRTPSDYRH 105
 
Name Accession Description Interval E-value
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
6-108 1.72e-29

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 102.70  E-value: 1.72e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149292723   6 HLALVCALSKWVETHLGRVIYLEELAAYSGYSLWHMQKIFKDVTGVSLGKYIRERLLAGAVYQLRSSDSTIFDIALDFGF 85
Cdd:PRK10219   3 HQKIIQTLIAWIDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDLGY 82

                         90       100
                 ....*....|....*....|...
gi 149292723  86 GSQSHFTYMFRKHYGITPYDFRQ 108
Cdd:PRK10219  83 VSQQTFSRVFRRQFDRTPSDYRH 105
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
25-107 6.11e-26

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 93.00  E-value: 6.11e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149292723    25 IYLEELAAYSGYSLWHMQKIFKDVTGVSLGKYIRERLLAGAVYQLRSSDSTIFDIALDFGFGSQSHFTYMFRKHYGITPY 104
Cdd:smart00342   2 LTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPS 81


                   ...
gi 149292723   105 DFR 107
Cdd:smart00342  82 EYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
3-109 7.04e-23

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 89.84  E-value: 7.04e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149292723   3 QENHLALVCALSKWVETHLGRVIYLEELAAYSGYSLWHMQKIFKDVTGVSLGKYIRERLLAGAVYQLRSSDSTIFDIALD 82
Cdd:COG2207  147 LLLLLLLLLLLLLLLLLLLLLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYE 226

                         90       100
                 ....*....|....*....|....*..
gi 149292723  83 FGFGSQSHFTYMFRKHYGITPYDFRQN 109
Cdd:COG2207  227 LGFSSQSHFSRAFKKRFGVTPSEYRKR 253
HTH_18 pfam12833
Helix-turn-helix domain;
30-109 8.90e-22

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 82.25  E-value: 8.90e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149292723   30 LAAYSGYSLWHMQKIFKDVTGVSLGKYIRERLLAGAVYQL-RSSDSTIFDIALDFGFGSQSHFTYMFRKHYGITPYDFRQ 108
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLlEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 149292723  109 N 109
Cdd:pfam12833  81 R 81
 
Name Accession Description Interval E-value
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
6-108 1.72e-29

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 102.70  E-value: 1.72e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149292723   6 HLALVCALSKWVETHLGRVIYLEELAAYSGYSLWHMQKIFKDVTGVSLGKYIRERLLAGAVYQLRSSDSTIFDIALDFGF 85
Cdd:PRK10219   3 HQKIIQTLIAWIDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDLGY 82

                         90       100
                 ....*....|....*....|...
gi 149292723  86 GSQSHFTYMFRKHYGITPYDFRQ 108
Cdd:PRK10219  83 VSQQTFSRVFRRQFDRTPSDYRH 105
PRK15121 PRK15121
MDR efflux pump AcrAB transcriptional activator RobA;
13-111 1.37e-26

MDR efflux pump AcrAB transcriptional activator RobA;


Pssm-ID: 185076 [Multi-domain]  Cd Length: 289  Bit Score: 100.08  E-value: 1.37e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149292723  13 LSKWVETHLGRVIYLEELAAYSGYSLWHMQKIFKDVTGVSLGKYIRERLLAGAVYQLRSSDSTIFDIALDFGFGSQSHFT 92
Cdd:PRK15121  10 LLIWLEGHLDQPLSLDNVAAKAGYSKWHLQRMFKDVTGHAIGAYIRARRLSKAAVALRLTSRPILDIALQYRFDSQQTFT 89

                         90
                 ....*....|....*....
gi 149292723  93 YMFRKHYGITPYDFRQNTD 111
Cdd:PRK15121  90 RAFKKQFAQTPALYRRSPE 108
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
25-107 6.11e-26

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 93.00  E-value: 6.11e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149292723    25 IYLEELAAYSGYSLWHMQKIFKDVTGVSLGKYIRERLLAGAVYQLRSSDSTIFDIALDFGFGSQSHFTYMFRKHYGITPY 104
Cdd:smart00342   2 LTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPS 81


                   ...
gi 149292723   105 DFR 107
Cdd:smart00342  82 EYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
3-109 7.04e-23

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 89.84  E-value: 7.04e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149292723   3 QENHLALVCALSKWVETHLGRVIYLEELAAYSGYSLWHMQKIFKDVTGVSLGKYIRERLLAGAVYQLRSSDSTIFDIALD 82
Cdd:COG2207  147 LLLLLLLLLLLLLLLLLLLLLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYE 226

                         90       100
                 ....*....|....*....|....*..
gi 149292723  83 FGFGSQSHFTYMFRKHYGITPYDFRQN 109
Cdd:COG2207  227 LGFSSQSHFSRAFKKRFGVTPSEYRKR 253
PRK11511 PRK11511
MDR efflux pump AcrAB transcriptional activator MarA;
1-107 1.55e-22

MDR efflux pump AcrAB transcriptional activator MarA;


Pssm-ID: 236920 [Multi-domain]  Cd Length: 127  Bit Score: 85.54  E-value: 1.55e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149292723   1 MSQENHLAL-VCALSKWVETHLGRVIYLEELAAYSGYSLWHMQKIFKDVTGVSLGKYIRERLLAGAVYQLRSSDSTIFDI 79
Cdd:PRK11511   1 MSRRNTDAItIHSILDWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKMTEIAQKLKESNEPILYL 80

                         90       100
                 ....*....|....*....|....*...
gi 149292723  80 ALDFGFGSQSHFTYMFRKHYGITPYDFR 107
Cdd:PRK11511  81 AERYGFESQQTLTRTFKNYFDVPPHKYR 108
HTH_18 pfam12833
Helix-turn-helix domain;
30-109 8.90e-22

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 82.25  E-value: 8.90e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149292723   30 LAAYSGYSLWHMQKIFKDVTGVSLGKYIRERLLAGAVYQL-RSSDSTIFDIALDFGFGSQSHFTYMFRKHYGITPYDFRQ 108
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLlEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 149292723  109 N 109
Cdd:pfam12833  81 R 81
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 16-108 1.68e-19

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 81.74  E-value: 1.68e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149292723  16 WVETHLGRVIYLEELAAYSGYSLWHMQKIFKDVTGVSLGKYIRE-RLLAgAVYQLRSSDSTIFDIALDFGFGSQSHFTYM 94
Cdd:COG4977  218 WMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRlRLER-ARRLLETTDLSIEEIAAACGFGSASHFRRA 296

                         90
                 ....*....|....
gi 149292723  95 FRKHYGITPYDFRQ 108
Cdd:COG4977  297 FRRRFGVSPSAYRR 310
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 6-108 1.79e-18

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 79.33  E-value: 1.79e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149292723   6 HLALVCALSKWVETHLGRVIYLEELAAYSGYSLWHMQKIFKDVTGVSLGKYIRERLLAGAVYQLRSSDSTIfDIALDFGF 85
Cdd:COG2169   82 RADLVARACRLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQLLQTGLSVT-DAAYAAGF 160

                         90       100
                 ....*....|....*....|...
gi 149292723  86 GSQSHFTYMFRKHYGITPYDFRQ 108
Cdd:COG2169  161 GSLSRFYEAFKKLLGMTPSAYRR 183
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
4-111 4.06e-15

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 69.32  E-value: 4.06e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149292723   4 ENHLALVCALSKWVETHLGRVIYLEELAAYSGYSLWHMQKIFKDVTGVSLGKYIRERLLAGAVYQLRSSDSTIFDIALDF 83
Cdd:PRK13503 167 ENSDARLNQLLAWLEDHFAEEVNWEALADQFSLSLRTLHRQLKQQTGLTPQRYLNRLRLLKARHLLRHSDASVTDIAYRC 246

                         90       100
                 ....*....|....*....|....*...
gi 149292723  84 GFGSQSHFTYMFRKHYGITPYDFRQNTD 111
Cdd:PRK13503 247 GFGDSNHFSTLFRREFSWSPRDIRQGRD 274
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
41-108 1.34e-11

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 59.92  E-value: 1.34e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 149292723  41 MQKIFKDVTGVSLGKYIRERLLAGAVYQLRSSDSTIFDIALDFGFGSQSHFTYMFRKHYGITPYDFRQ 108
Cdd:PRK13501 209 LKQLFRQQTGMSISHYLRQIRLCHAKCLLRGSEHRISDIAARCGFEDSNYFSAVFTREAGMTPRDYRQ 276
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 28-108 6.34e-09

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 52.34  E-value: 6.34e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149292723  28 EELAAYSGYSLWHMQKIFKDvTGVSLGKYIRERLLAGAVYQLRS--SDSTIFDIALDFGFGSQSHFTYMFRKHYGITPYD 105
Cdd:PRK09685 218 EWIAGELGISVRSLYRLFAE-QGLVVAQYIRNRRLDRCADDLRPaaDDEKITSIAYKWGFSDSSHFSTAFKQRFGVSPGE 296


                 ...
gi 149292723 106 FRQ 108
Cdd:PRK09685 297 YRR 299
ftrA PRK09393
transcriptional activator FtrA; Provisional
 16-109 2.01e-08

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 50.73  E-value: 2.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149292723  16 WVETHLGRVIYLEELAAYSGYSLWHMQKIFKDVTGVSLGKY-IRERLLAGAVYqLRSSDSTIFDIALDFGFGSQSHFTYM 94
Cdd:PRK09393 226 WMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWlLRERLARARDL-LESSALSIDQIAERAGFGSEESLRHH 304

                         90
                 ....*....|....*
gi 149292723  95 FRKHYGITPYDFRQN 109
Cdd:PRK09393 305 FRRRAATSPAAYRKR 319
PRK10371 PRK10371
transcriptional regulator MelR;
20-108 3.89e-07

transcriptional regulator MelR;


Pssm-ID: 182416 [Multi-domain]  Cd Length: 302  Bit Score: 47.12  E-value: 3.89e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149292723  20 HLGRVIYLEELAAYSGYSLWHMQKIFKDVTGVSLGKYIRERLLAGAVYQLRSSDSTIFDIALDFGFGSQSHFTYMFRKHY 99
Cdd:PRK10371 203 NYDQALTINDVAEHVKLNANYAMGIFQRVMQLTMKQYITAMRINHVRALLSDTDKSILDIALTAGFRSSSRFYSTFGKYV 282


                 ....*....
gi 149292723 100 GITPYDFRQ 108
Cdd:PRK10371 283 GMSPQQYRK 291
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
19-107 4.46e-06

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 44.19  E-value: 4.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149292723  19 THLGRVIYLEELAAY---SGYSLWHMqkiFKDVTGVSLGKY------IRERLLagavyqLRSSDSTIFDIALDFGFGSQS 89
Cdd:PRK10572 194 DHLASEFDIESVAQHvclSPSRLAHL---FRQQLGISVLRWredqriSRAKLL------LQTTRMPIATIGRNVGYDDQL 264

                         90
                 ....*....|....*...
gi 149292723  90 HFTYMFRKHYGITPYDFR 107
Cdd:PRK10572 265 YFSRVFKKCTGASPSEFR 282
PRK13500 PRK13500
HTH-type transcriptional activator RhaR;
41-108 8.11e-06

HTH-type transcriptional activator RhaR;


Pssm-ID: 184091 [Multi-domain]  Cd Length: 312  Bit Score: 43.55  E-value: 8.11e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 149292723  41 MQKIFKDVTGVSLGKYIRERLLAGAVYQLRSSDSTIFDIALDFGFGSQSHFTYMFRKHYGITPYDFRQ 108
Cdd:PRK13500 239 LRQQFRQQTGMTINQYLRQVRVCHAQYLLQHSRLLISDISTECGFEDSNYFSVVFTRETGMTPSQWRH 306
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 71-108 8.72e-06

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 40.21  E-value: 8.72e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 149292723   71 SSDSTIFDIALDFGFgSQSHFTYMFRKHYGITPYDFRQ 108
Cdd:pfam00165   6 STNLTIADIADELGF-SRSYFSRLFKKYTGVTPSQYRH 42
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
41-108 1.10e-05

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 43.12  E-value: 1.10e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 149292723  41 MQKIFKDVTGVSLGKYIRERLLAGAVYQLRSSDSTIFDIALDFGFGSQSHFTYMFRKHYGITPYDFRQ 108
Cdd:PRK13502 209 LRQQFRAQTGMTINQYLRQVRICHAQYLLQHSPLMISEISMQCGFEDSNYFSVVFTRETGMTPSQWRH 276
PRK09978 PRK09978
DNA-binding transcriptional regulator GadX; Provisional
 50-108 1.23e-04

DNA-binding transcriptional regulator GadX; Provisional


Pssm-ID: 137624 [Multi-domain]  Cd Length: 274  Bit Score: 39.91  E-value: 1.23e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 149292723  50 GVSLGKYIRERLLAGAVYQLRSSDSTIFDIALDFGFGSQSHFTYMFRKHYGITPYDFRQ 108
Cdd:PRK09978 183 ETSYSQLLTECRMQRALQLIVIHGFSIKRVAVSCGYHSVSYFIYVFRNYYGMTPTEYQE 241
PRK15186 PRK15186
AraC family transcriptional regulator; Provisional
 69-106 3.24e-03

AraC family transcriptional regulator; Provisional


Pssm-ID: 185108 [Multi-domain]  Cd Length: 291  Bit Score: 35.81  E-value: 3.24e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 149292723  69 LRSSDSTIFDIALDFGFGSQSHFTYMFRKHYGITPYDF 106
Cdd:PRK15186 241 LRNSEYNITRVAYMCGYDSASYFTCVFKKHFKTTPSEF 278
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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