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Conserved domains on  [gi|149241559]
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Chain X, Cytochrome c oxidase polypeptide VIIb

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cyt_c_Oxidase_VIIb super family cl22629
Cytochrome C oxidase chain VIIb. Cytochrome c oxidase (CcO), the terminal oxidase in the ...
 1-55 3.12e-40

Cytochrome C oxidase chain VIIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. The VIIb subunit is found only in eukaryotes and its specific function remains unclear. A rare polymorphism of the CcO VIIb gene may be associated with the high risk of nasopharyngeal carcinoma in a Cantonese family.


The actual alignment was detected with superfamily member pfam05392:

Pssm-ID: 473970  Cd Length: 78  Bit Score: 125.60  E-value: 3.12e-40
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 149241559   1 IHQKRAPDFHDKYGNAVLASGATFCVAVWVYMATQIGIEWNPSPVGRVTPKEWRE 55
Cdd:pfam05392 24 SHRKHSPDFHDKYGNAVLASGAAFCVAVWVYVATQIGIEWNLSPVGRVTPKEWRE 78
 
Name Accession Description Interval E-value
COX7B pfam05392
Cytochrome C oxidase chain VIIB;
1-55 3.12e-40

Cytochrome C oxidase chain VIIB;


Pssm-ID: 461637  Cd Length: 78  Bit Score: 125.60  E-value: 3.12e-40
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 149241559   1 IHQKRAPDFHDKYGNAVLASGATFCVAVWVYMATQIGIEWNPSPVGRVTPKEWRE 55
Cdd:pfam05392 24 SHRKHSPDFHDKYGNAVLASGAAFCVAVWVYVATQIGIEWNLSPVGRVTPKEWRE 78
Cyt_c_Oxidase_VIIb cd01403
Cytochrome C oxidase chain VIIb. Cytochrome c oxidase (CcO), the terminal oxidase in the ...
 5-55 1.93e-32

Cytochrome C oxidase chain VIIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. The VIIb subunit is found only in eukaryotes and its specific function remains unclear. A rare polymorphism of the CcO VIIb gene may be associated with the high risk of nasopharyngeal carcinoma in a Cantonese family.


Pssm-ID: 238696  Cd Length: 51  Bit Score: 105.26  E-value: 1.93e-32
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 149241559  5 RAPDFHDKYGNAVLASGATFCVAVWVYMATQIGIEWNPSPVGRVTPKEWRE 55
Cdd:cd01403   1 ASPDFHDKYGNAVLISGATFCTAVWTYVMTQTGIEWNLSPVGRVTPKEWRE 51
 
Name Accession Description Interval E-value
COX7B pfam05392
Cytochrome C oxidase chain VIIB;
1-55 3.12e-40

Cytochrome C oxidase chain VIIB;


Pssm-ID: 461637  Cd Length: 78  Bit Score: 125.60  E-value: 3.12e-40
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 149241559   1 IHQKRAPDFHDKYGNAVLASGATFCVAVWVYMATQIGIEWNPSPVGRVTPKEWRE 55
Cdd:pfam05392 24 SHRKHSPDFHDKYGNAVLASGAAFCVAVWVYVATQIGIEWNLSPVGRVTPKEWRE 78
Cyt_c_Oxidase_VIIb cd01403
Cytochrome C oxidase chain VIIb. Cytochrome c oxidase (CcO), the terminal oxidase in the ...
 5-55 1.93e-32

Cytochrome C oxidase chain VIIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. The VIIb subunit is found only in eukaryotes and its specific function remains unclear. A rare polymorphism of the CcO VIIb gene may be associated with the high risk of nasopharyngeal carcinoma in a Cantonese family.


Pssm-ID: 238696  Cd Length: 51  Bit Score: 105.26  E-value: 1.93e-32
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 149241559  5 RAPDFHDKYGNAVLASGATFCVAVWVYMATQIGIEWNPSPVGRVTPKEWRE 55
Cdd:cd01403   1 ASPDFHDKYGNAVLISGATFCTAVWTYVMTQTGIEWNLSPVGRVTPKEWRE 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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