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Conserved domains on  [gi|1491196577|gb|RLG76659|]
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MAG: hypothetical protein DRO23_00290 [Thermoprotei archaeon]

Protein Classification

helix-turn-helix transcriptional regulator( domain architecture ID 11457519)

helix-turn-helix (HTH) transcriptional regulator containing a DNA-binding HTH domain, may act as a transcriptional activator or as a transcriptional repressor

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
1-72 2.96e-16

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


:

Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 66.09  E-value: 2.96e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1491196577  1 MLETAPLIDEKDRQILEVLRKLGGEAAQTTVVKYTGLPKSTISRKIKKLEKLGYIKVIKRGRVNILKIIKEE 72
Cdd:COG2512    6 ALLLYPELLEDERRVLELLRENGGRMTQSEIVKETGWSKSKVSRLLSRLEERGLIEKERVGRENVVELPEDE 77
 
Name Accession Description Interval E-value
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
1-72 2.96e-16

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 66.09  E-value: 2.96e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1491196577  1 MLETAPLIDEKDRQILEVLRKLGGEAAQTTVVKYTGLPKSTISRKIKKLEKLGYIKVIKRGRVNILKIIKEE 72
Cdd:COG2512    6 ALLLYPELLEDERRVLELLRENGGRMTQSEIVKETGWSKSKVSRLLSRLEERGLIEKERVGRENVVELPEDE 77
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
8-56 7.10e-08

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 45.20  E-value: 7.10e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1491196577    8 IDEKDRQILEVLRKlGGEAAQTTVVKYTGLPKSTISRKIKKLEKLGYIK 56
Cdd:smart00344   1 LDEIDRKILEELQK-DARISLAELAKKVGLSPSTVHNRVKRLEEEGVIK 48
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
7-68 6.67e-07

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 42.29  E-value: 6.67e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1491196577  7 LIDEKDRQILEVLRKlgGEAAQTTVVKYTGLPKSTISRKIKKLEKLGYIKVIKRGRVNILKI 68
Cdd:cd00090    4 LSDPTRLRILRLLLE--GPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSL 63
HTH_IclR pfam09339
IclR helix-turn-helix domain;
14-55 3.23e-05

IclR helix-turn-helix domain;


Pssm-ID: 430539 [Multi-domain]  Cd Length: 52  Bit Score: 37.00  E-value: 3.23e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 1491196577 14 QILEVLRKLGGEAAQTTVVKYTGLPKSTISRKIKKLEKLGYI 55
Cdd:pfam09339  7 AILDALAEAPGPLTLTEIARRTGLPKSTAHRLLQTLVELGYV 48
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
9-62 5.44e-04

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 34.74  E-value: 5.44e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 1491196577  9 DEKDRQILEVLRKlgGEAAQTTVVKYTGLPKSTISRKIKKLEKLGYIKVIKRGR 62
Cdd:NF033788  10 DPTRLRILELLAE--GELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGR 61
PRK09834 PRK09834
DNA-binding transcriptional regulator;
14-55 2.03e-03

DNA-binding transcriptional regulator;


Pssm-ID: 182100 [Multi-domain]  Cd Length: 263  Bit Score: 34.58  E-value: 2.03e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1491196577  14 QILEVLRKLGGEAAQTTVVKYTGLPKSTISRKIKKLEKLGYI 55
Cdd:PRK09834   15 MVLRALNRLDGGATVGLLAELTGLHRTTVRRLLETLQEEGYV 56
 
Name Accession Description Interval E-value
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
1-72 2.96e-16

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 66.09  E-value: 2.96e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1491196577  1 MLETAPLIDEKDRQILEVLRKLGGEAAQTTVVKYTGLPKSTISRKIKKLEKLGYIKVIKRGRVNILKIIKEE 72
Cdd:COG2512    6 ALLLYPELLEDERRVLELLRENGGRMTQSEIVKETGWSKSKVSRLLSRLEERGLIEKERVGRENVVELPEDE 77
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
8-56 7.10e-08

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 45.20  E-value: 7.10e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1491196577    8 IDEKDRQILEVLRKlGGEAAQTTVVKYTGLPKSTISRKIKKLEKLGYIK 56
Cdd:smart00344   1 LDEIDRKILEELQK-DARISLAELAKKVGLSPSTVHNRVKRLEEEGVIK 48
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
7-68 6.67e-07

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 42.29  E-value: 6.67e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1491196577  7 LIDEKDRQILEVLRKlgGEAAQTTVVKYTGLPKSTISRKIKKLEKLGYIKVIKRGRVNILKI 68
Cdd:cd00090    4 LSDPTRLRILRLLLE--GPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSL 63
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
8-56 1.41e-05

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 39.76  E-value: 1.41e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1491196577   8 IDEKDRQILEVLRKlGGEAAQTTVVKYTGLPKSTISRKIKKLEKLGYIK 56
Cdd:COG1522     3 LDEIDRRILRLLQE-DGRLSFAELAERVGLSESTVLRRVRRLEEAGVIR 50
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
13-62 2.47e-05

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 38.33  E-value: 2.47e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 1491196577 13 RQILEVLRKlgGEAAQTTVVKYTGLPKSTISRKIKKLEKLGYIKVIKRGR 62
Cdd:COG0640   23 LRILRLLAE--GELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGR 70
HTH_IclR pfam09339
IclR helix-turn-helix domain;
14-55 3.23e-05

IclR helix-turn-helix domain;


Pssm-ID: 430539 [Multi-domain]  Cd Length: 52  Bit Score: 37.00  E-value: 3.23e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 1491196577 14 QILEVLRKLGGEAAQTTVVKYTGLPKSTISRKIKKLEKLGYI 55
Cdd:pfam09339  7 AILDALAEAPGPLTLTEIARRTGLPKSTAHRLLQTLVELGYV 48
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
10-73 4.29e-05

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 38.71  E-value: 4.29e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1491196577  10 EKDRQILEVLRKLGGeAAQTTVVKYTGLPKSTISRKIKKLEKLGYIKVIKRGRVNILKIIKEET 73
Cdd:COG3398    97 ETPRRILLYLLENPG-ATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYLNPPER 159
IclR COG1414
DNA-binding transcriptional regulator, IclR family [Transcription];
14-55 4.47e-05

DNA-binding transcriptional regulator, IclR family [Transcription];


Pssm-ID: 441024 [Multi-domain]  Cd Length: 253  Bit Score: 39.03  E-value: 4.47e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1491196577  14 QILEVLRKLGGEAAQTTVVKYTGLPKSTISRKIKKLEKLGYI 55
Cdd:COG1414    13 AILEALAEAGGGLSLSELARRLGLPKSTVHRLLATLEEEGYV 54
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
14-62 6.97e-05

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 36.80  E-value: 6.97e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1491196577  14 QILEVLRKlgGEAAQTTVVKYTGLPKSTISRKIKKLEKLGYIKVIKRGR 62
Cdd:smart00418  1 KILKLLAE--GELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGK 47
COG3888 COG3888
Predicted transcriptional regulator [Transcription];
12-59 1.18e-04

Predicted transcriptional regulator [Transcription];


Pssm-ID: 443096 [Multi-domain]  Cd Length: 328  Bit Score: 38.08  E-value: 1.18e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1491196577  12 DRQILEVLRKLGGE-AAQTTVVKYTGLPKSTISRKIKKLEKLGYIKVIK 59
Cdd:COG3888     5 REKILRILKNYGGEgIPQSELVRLLGASKSRVSEILSELEKEGLIARKK 53
HTH_27 pfam13463
Winged helix DNA-binding domain;
12-56 1.58e-04

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 35.73  E-value: 1.58e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 1491196577 12 DRQILEVLRKLGGEAAQTTVVKYTGLPKSTISRKIKKLEKLGYIK 56
Cdd:pfam13463  5 EALILHNIGHRGDPKTLADICFRLNVEDSHVSYSLKKLTEAGLVE 49
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
14-57 1.79e-04

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 35.64  E-value: 1.79e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 1491196577 14 QILEVLRKlGGEAAQTTVVKYTGLPKSTISRKIKKLEKLGYIKV 57
Cdd:pfam12802  9 RVLLALAR-NPGLTVAELARRLGISKQTVSRLVKRLEAKGLVER 51
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
9-62 5.44e-04

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 34.74  E-value: 5.44e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 1491196577  9 DEKDRQILEVLRKlgGEAAQTTVVKYTGLPKSTISRKIKKLEKLGYIKVIKRGR 62
Cdd:NF033788  10 DPTRLRILELLAE--GELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGR 61
HTH_ICLR smart00346
helix_turn_helix isocitrate lyase regulation;
14-55 6.30e-04

helix_turn_helix isocitrate lyase regulation;


Pssm-ID: 214629 [Multi-domain]  Cd Length: 91  Bit Score: 34.87  E-value: 6.30e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1491196577  14 QILEVLRKLGGEAAQTTVVKYTGLPKSTISRKIKKLEKLGYI 55
Cdd:smart00346  9 AVLRALAEEPGGLTLAELAERLGLSKSTAHRLLNTLQELGYV 50
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
14-56 1.15e-03

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 34.95  E-value: 1.15e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1491196577  14 QILEVLRKLGGeAAQTTVVKYTGLPKSTISRKIKKLEKLGYIK 56
Cdd:COG1846    42 RVLAALAEAGG-LTQSELAERLGLTKSTVSRLLDRLEEKGLVE 83
PriA COG1198
Primosomal protein N' (replication factor Y) - superfamily II helicase [Replication, ...
10-60 1.28e-03

Primosomal protein N' (replication factor Y) - superfamily II helicase [Replication, recombination and repair];


Pssm-ID: 440811 [Multi-domain]  Cd Length: 728  Bit Score: 35.09  E-value: 1.28e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1491196577  10 EKDRQILEVLRKLGGEAAQTTVVKYTGLPKSTisrkIKKLEKLGYIKVIKR 60
Cdd:COG1198   131 PKQRRVLEALREHGGPLTLSELAKEAGVSRSV----LKALVKKGLLEIEER 177
COG3355 COG3355
Predicted transcriptional regulator [Transcription];
10-69 1.49e-03

Predicted transcriptional regulator [Transcription];


Pssm-ID: 442583 [Multi-domain]  Cd Length: 131  Bit Score: 34.17  E-value: 1.49e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1491196577  10 EKDRQILEVLRKLGGEAAQTTVVKYTGLPKSTISRKIKKLEKLGYIKVIKR-----GRVNILKII 69
Cdd:COG3355    27 ETDAEVYLILLENGEPLTVEELAEALDRSRSTVYRSLQKLLEAGLVEREKRnleggGYPYVYYAI 91
PRK09834 PRK09834
DNA-binding transcriptional regulator;
14-55 2.03e-03

DNA-binding transcriptional regulator;


Pssm-ID: 182100 [Multi-domain]  Cd Length: 263  Bit Score: 34.58  E-value: 2.03e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1491196577  14 QILEVLRKLGGEAAQTTVVKYTGLPKSTISRKIKKLEKLGYI 55
Cdd:PRK09834   15 MVLRALNRLDGGATVGLLAELTGLHRTTVRRLLETLQEEGYV 56
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
9-55 2.08e-03

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 32.42  E-value: 2.08e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 1491196577  9 DEKDRQILEVLRKlgGEAAQTTVVKYTGLPKSTISRKIKKLEKLGYI 55
Cdd:pfam01022  1 DPTRLKILKLLAE--GELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
HTH_CRP cd00092
helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic ...
33-67 3.71e-03

helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family.


Pssm-ID: 238044 [Multi-domain]  Cd Length: 67  Bit Score: 32.25  E-value: 3.71e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 1491196577 33 KYTGLPKSTISRKIKKLEKLGYIKVIKRGRVNILK 67
Cdd:cd00092   33 DYLGLTRETVSRTLKELEEEGLISRRGRGKYRVNP 67
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
9-50 3.81e-03

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 31.57  E-value: 3.81e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 1491196577  9 DEKDRQILEVLRKlGGEAAQTTVVKYTGLPKSTISRKIKKLE 50
Cdd:pfam13404  1 DEIDRKILRLLQE-DARISFAELAERVGLSESTVLRRIRRLE 41
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
14-63 6.16e-03

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 32.87  E-value: 6.16e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1491196577  14 QILEVLRKL---GGEAAQTTVVKYTGLPKSTISRKIKKLEKLGYIKVIKRGRV 63
Cdd:COG1321    10 DYLKAIYELseeGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGGI 62
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
10-55 6.33e-03

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 31.25  E-value: 6.33e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 1491196577 10 EKDRQILEVLRKlGGEAAQTTVVKYTGLPKSTISRKIKKLEKLGYI 55
Cdd:pfam13412  1 ETDRKILNLLQE-NPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
PRK14165 PRK14165
winged helix-turn-helix domain-containing protein/riboflavin kinase; Provisional
14-61 6.68e-03

winged helix-turn-helix domain-containing protein/riboflavin kinase; Provisional


Pssm-ID: 184548 [Multi-domain]  Cd Length: 217  Bit Score: 33.11  E-value: 6.68e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1491196577  14 QILEVLRKLGGEAAQTTVVK--------YTGLPKSTISRKIKKLEKLGYI--KVIKRG 61
Cdd:PRK14165    2 PDIEALKKLALLGAVNNTVKisssefanHTGTSSKTAARILKQLEDEGYItrTIVPRG 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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