NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1491196575|gb|RLG76657|]
View 

MAG: magnesium chelatase [Thermoprotei archaeon]

Protein Classification

AAA family ATPase( domain architecture ID 11431245)

AAA family ATPase with an AAA (ATPases Associated with various cellular Activities) domain functions as a modulator of stress response pathways and may have a chaperone-like role for the maturation of specific protein complexes or for the insertion of cofactors into proteins; similar to MoxR that is involved in the formation of active methanol dehydrogenase

CATH:  3.40.50.300
Gene Ontology:  GO:0005524|GO:0016887
PubMed:  16072036|11916378|15037234|17897320|18466635
SCOP:  2000039

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 1-261 1.74e-130

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


:

Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 372.19  E-value: 1.74e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575   1 MTVTLLSRGHMLIEGPPGTAKTLMAKLFAEALGLTFKRIQMTPDMIPADIIGAKIIDPKTGDLRLVLGPIFANIVLIDEI 80
Cdd:COG0714    24 VLIALLAGGHLLLEGVPGVGKTTLAKALARALGLPFIRIQFTPDLLPSDILGTYIYDQQTGEFEFRPGPLFANVLLADEI 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575  81 NRASPKTQSALLEAMQERHVTIEGDTHKLPDPFLVIATQNPWETEGVFPLPETQIDRFSLAISVSYPSPDVELSILAKDH 160
Cdd:COG0714   104 NRAPPKTQSALLEAMEERQVTIPGGTYKLPEPFLVIATQNPIEQEGTYPLPEAQLDRFLLKLYIGYPDAEEEREILRRHT 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575 161 ElkGLEPKIEPIISKEELLKAIAESSEIHVEEKIMKYIVEIVRKTREMPEIVLGVSPRTSVILLRTAKALAAIRGRKYVI 240
Cdd:COG0714   184 G--RHLAEVEPVLSPEELLALQELVRQVHVSEAVLDYIVDLVRATREHPDLRKGPSPRASIALLRAARALALLDGRDYVT 261

                         250       260
                  ....*....|....*....|.
gi 1491196575 241 PDDIKYLTPYVLWHRIKLSPR 261
Cdd:COG0714   262 PDDVKAVAGPVLKHRLILSPE 282
 
Name Accession Description Interval E-value
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 1-261 1.74e-130

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 372.19  E-value: 1.74e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575   1 MTVTLLSRGHMLIEGPPGTAKTLMAKLFAEALGLTFKRIQMTPDMIPADIIGAKIIDPKTGDLRLVLGPIFANIVLIDEI 80
Cdd:COG0714    24 VLIALLAGGHLLLEGVPGVGKTTLAKALARALGLPFIRIQFTPDLLPSDILGTYIYDQQTGEFEFRPGPLFANVLLADEI 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575  81 NRASPKTQSALLEAMQERHVTIEGDTHKLPDPFLVIATQNPWETEGVFPLPETQIDRFSLAISVSYPSPDVELSILAKDH 160
Cdd:COG0714   104 NRAPPKTQSALLEAMEERQVTIPGGTYKLPEPFLVIATQNPIEQEGTYPLPEAQLDRFLLKLYIGYPDAEEEREILRRHT 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575 161 ElkGLEPKIEPIISKEELLKAIAESSEIHVEEKIMKYIVEIVRKTREMPEIVLGVSPRTSVILLRTAKALAAIRGRKYVI 240
Cdd:COG0714   184 G--RHLAEVEPVLSPEELLALQELVRQVHVSEAVLDYIVDLVRATREHPDLRKGPSPRASIALLRAARALALLDGRDYVT 261

                         250       260
                  ....*....|....*....|.
gi 1491196575 241 PDDIKYLTPYVLWHRIKLSPR 261
Cdd:COG0714   262 PDDVKAVAGPVLKHRLILSPE 282
AAA_3 pfam07726
ATPase family associated with various cellular activities (AAA); This Pfam entry includes some ...
 10-138 1.04e-80

ATPase family associated with various cellular activities (AAA); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 429622 [Multi-domain]  Cd Length: 131  Bit Score: 239.77  E-value: 1.04e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575  10 HMLIEGPPGTAKTLMAKLFAEALGLTFKRIQMTPDMIPADIIGAKIIDPKTGDLRLVLGPIFANIVLIDEINRASPKTQS 89
Cdd:pfam07726   1 HVLLEGVPGLAKTLLVRTLARSLGLDFRRIQFTPDLLPSDITGTEVFDQKTREFEFRPGPVFANVLLADEINRAPPKTQS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1491196575  90 ALLEAMQERHVTIEGDTHKLPDPFLVIATQNPWETEGVFPLPETQIDRF 138
Cdd:pfam07726  81 ALLEAMQERQVTIDGETHPLPEPFFVLATQNPIEQEGTYPLPEAQLDRF 129
MCM cd17706
MCM helicase family; MCM helicases are a family of helicases that play an important role in ...
 10-245 8.20e-10

MCM helicase family; MCM helicases are a family of helicases that play an important role in replication and homologous recombination repair. The heterohexameric ring-shaped Mcm2-7 complex is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. Mcm8 and Mcm9, form a complex required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350658 [Multi-domain]  Cd Length: 311  Bit Score: 58.51  E-value: 8.20e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575  10 HMLIEGPPGTAKTLMAKlfaealgltfKRIQMTPDMIPADIIGAKII--------DPKTGDLRLVLGP-IFAN--IVLID 78
Cdd:cd17706    43 HILLVGDPGTAKSQILK----------YVLKIAPRGVYTSGKGSSGAgltaavvrDSETGEWYLEAGAlVLADggVCCID 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575  79 EINRASPKTQSALLEAMQERHVTIE--GDTHKLPDPFLVIATQNPweTEGVFP----------LPETQIDRFSLaISVSY 146
Cdd:cd17706   113 EFDKMKELDRTALHEAMEQQTISIAkaGIVTTLNARCSILAAANP--KGGRYNpklspieninLPSPLLSRFDL-IFVIR 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575 147 PSPDVE----------LSILAKDHELKGLEPKIEPIISKEELLKAIAESSEIH--VEEKIMKYIVEIVRKTREMPEIV-- 212
Cdd:cd17706   190 DDPDEErdeelaehiiDLHRGSDPEEQVKPEEDGIPIDIELLRKYILYARQIHpkISEEAREKLVRWYVELRKESERRst 269

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1491196575 213 LGVSPRTSVILLRTAKALAAIRGRKYVIPDDIK 245
Cdd:cd17706   270 IPITARQLESVIRLAEAHAKMRLSEVVTEEDVE 302
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 7-126 3.44e-05

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 43.13  E-value: 3.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575    7 SRGHMLIEGPPGTAKTLMAKLFAEALGLTFKRI------QMTPDMIPADIIGAKIIDPKTGDLRLVLGPIFAN------- 73
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPGGGViyidgeDILEEVLDQLLLIIVGGKKASGSGELRLRLALALarklkpd 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1491196575   74 IVLIDEINRASPKTQSALLEAMQERHVTIEgdtHKLPDPFLVIATQNPWETEG 126
Cdd:smart00382  81 VLILDEITSLLDAEQEALLLLLEELRLLLL---LKSEKNLTVILTTNDEKDLG 130
ruvB PRK00080
Holliday junction branch migration DNA helicase RuvB;
10-118 3.36e-04

Holliday junction branch migration DNA helicase RuvB;


Pssm-ID: 234619 [Multi-domain]  Cd Length: 328  Bit Score: 41.65  E-value: 3.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575  10 HMLIEGPPGTAKTLMAKLFAEALGLTFKriqmtpdmipadIIGAKIIDpKTGDLRLVLGPIFANIVL-IDEINRASPKTQ 88
Cdd:PRK00080   53 HVLLYGPPGLGKTTLANIIANEMGVNIR------------ITSGPALE-KPGDLAAILTNLEEGDVLfIDEIHRLSPVVE 119

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1491196575  89 SALLEAMQERHVTI---EGDTHK-----LPdPF-LVIAT 118
Cdd:PRK00080  120 EILYPAMEDFRLDImigKGPAARsirldLP-PFtLIGAT 157
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 11-236 3.35e-03

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 38.73  E-value: 3.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575  11 MLIEGPPGTAKTLMAKLFAEALGLTFKRIQmtpdmipadiiGAKIIDPKTGDLRLVLGPIFAN-------IVLIDEINRA 83
Cdd:TIGR01243 490 VLLFGPPGTGKTLLAKAVATESGANFIAVR-----------GPEILSKWVGESEKAIREIFRKarqaapaIIFFDEIDAI 558

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575  84 SPKTQSALLEAMQERHVT---IEGDTHKLPDPFLVIATQNPWETEGVFPLPETQIDRFSLAisvsyPSPDVELSI----- 155
Cdd:TIGR01243 559 APARGARFDTSVTDRIVNqllTEMDGIQELSNVVVIAATNRPDILDPALLRPGRFDRLILV-----PPPDEEARKeifki 633

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575 156 ------LAKDHELKGLEPKIE-------PIISKEELLKAIAESSEIHVEEKIMKYIVEIVRKT----REMPEIVLGVSPR 218
Cdd:TIGR01243 634 htrsmpLAEDVDLEELAEMTEgytgadiEAVCREAAMAALRESIGSPAKEKLEVGEEEFLKDLkvemRHFLEALKKVKPS 713

                         250
                  ....*....|....*...
gi 1491196575 219 TSVILLRTAKALAAIRGR 236
Cdd:TIGR01243 714 VSKEDMLRYERLAKELKR 731
 
Name Accession Description Interval E-value
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 1-261 1.74e-130

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 372.19  E-value: 1.74e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575   1 MTVTLLSRGHMLIEGPPGTAKTLMAKLFAEALGLTFKRIQMTPDMIPADIIGAKIIDPKTGDLRLVLGPIFANIVLIDEI 80
Cdd:COG0714    24 VLIALLAGGHLLLEGVPGVGKTTLAKALARALGLPFIRIQFTPDLLPSDILGTYIYDQQTGEFEFRPGPLFANVLLADEI 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575  81 NRASPKTQSALLEAMQERHVTIEGDTHKLPDPFLVIATQNPWETEGVFPLPETQIDRFSLAISVSYPSPDVELSILAKDH 160
Cdd:COG0714   104 NRAPPKTQSALLEAMEERQVTIPGGTYKLPEPFLVIATQNPIEQEGTYPLPEAQLDRFLLKLYIGYPDAEEEREILRRHT 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575 161 ElkGLEPKIEPIISKEELLKAIAESSEIHVEEKIMKYIVEIVRKTREMPEIVLGVSPRTSVILLRTAKALAAIRGRKYVI 240
Cdd:COG0714   184 G--RHLAEVEPVLSPEELLALQELVRQVHVSEAVLDYIVDLVRATREHPDLRKGPSPRASIALLRAARALALLDGRDYVT 261

                         250       260
                  ....*....|....*....|.
gi 1491196575 241 PDDIKYLTPYVLWHRIKLSPR 261
Cdd:COG0714   262 PDDVKAVAGPVLKHRLILSPE 282
AAA_3 pfam07726
ATPase family associated with various cellular activities (AAA); This Pfam entry includes some ...
 10-138 1.04e-80

ATPase family associated with various cellular activities (AAA); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 429622 [Multi-domain]  Cd Length: 131  Bit Score: 239.77  E-value: 1.04e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575  10 HMLIEGPPGTAKTLMAKLFAEALGLTFKRIQMTPDMIPADIIGAKIIDPKTGDLRLVLGPIFANIVLIDEINRASPKTQS 89
Cdd:pfam07726   1 HVLLEGVPGLAKTLLVRTLARSLGLDFRRIQFTPDLLPSDITGTEVFDQKTREFEFRPGPVFANVLLADEINRAPPKTQS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1491196575  90 ALLEAMQERHVTIEGDTHKLPDPFLVIATQNPWETEGVFPLPETQIDRF 138
Cdd:pfam07726  81 ALLEAMQERQVTIDGETHPLPEPFFVLATQNPIEQEGTYPLPEAQLDRF 129
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 10-138 2.49e-20

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 84.65  E-value: 2.49e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575  10 HMLIEGPPGTAKTLMAKLFAEAL-GLTFKRIQMTPDMIPADIIGakIIDPKTGDLRLVLGPIF-----ANIVLIDEINRA 83
Cdd:pfam07728   1 GVLLVGPPGTGKTELAERLAAALsNRPVFYVQLTRDTTEEDLFG--RRNIDPGGASWVDGPLVraareGEIAVLDEINRA 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1491196575  84 SPKTQSALLEAMQERHVTIE---GDTHKLPDPFLVIATQNPWETEGVFPLPETQiDRF 138
Cdd:pfam07728  79 NPDVLNSLLSLLDERRLLLPdggELVKAAPDGFRLIATMNPLDRGLNELSPALR-SRF 135
AAA_lid_2 pfam17863
AAA lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
 203-270 8.04e-17

AAA lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


Pssm-ID: 465538 [Multi-domain]  Cd Length: 73  Bit Score: 73.40  E-value: 8.04e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1491196575 203 RKTREMPEIVLGVSPRTSVI-LLRTAKALAAIRGRKYVIPDDIKYLTPYVLWHRIKLSPRIASFITPEE 270
Cdd:pfam17863   1 LATRAHLAIALGVSPRRADLaLLRAARALAALEGRDYVTPEDVKEAAPLVLAHRLRREPEAEGETAEEI 69
ChlI COG1239
Mg-chelatase subunit ChlI [Coenzyme transport and metabolism];
73-257 8.04e-13

Mg-chelatase subunit ChlI [Coenzyme transport and metabolism];


Pssm-ID: 440852 [Multi-domain]  Cd Length: 344  Bit Score: 67.47  E-value: 8.04e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575  73 NIVLIDEINRASPKTQSALLEAMQERHVTIEGD----THklPDPFLVIATQNPWETEgvfpLPETQIDRFSLAISVSYP- 147
Cdd:COG1239   138 GILYVDEVNLLDDHLVDVLLDAAAMGRNTVEREgvsvSH--PARFVLVGTMNPEEGE----LRPQLLDRFGLSVEVEGPr 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575 148 SPDVELSIL------AKDHE--LKGLEPKIEPIisKEELLKAIAESSEIHVEEKIMKYIVEIVRKtrempeivLGV-SPR 218
Cdd:COG1239   212 DPEERVEIVrrrlafEADPEafAAEYAEEQAEL--RERIAAARELLPEVTIPDELLRYIAELCIA--------LGVdGHR 281

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1491196575 219 TSVILLRTAKALAAIRGRKYVIPDDIKYLTPYVLWHRIK 257
Cdd:COG1239   282 ADIVIARAARALAALEGRTEVTAEDIRRAAELALPHRLR 320
MCM cd17706
MCM helicase family; MCM helicases are a family of helicases that play an important role in ...
 10-245 8.20e-10

MCM helicase family; MCM helicases are a family of helicases that play an important role in replication and homologous recombination repair. The heterohexameric ring-shaped Mcm2-7 complex is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. Mcm8 and Mcm9, form a complex required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350658 [Multi-domain]  Cd Length: 311  Bit Score: 58.51  E-value: 8.20e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575  10 HMLIEGPPGTAKTLMAKlfaealgltfKRIQMTPDMIPADIIGAKII--------DPKTGDLRLVLGP-IFAN--IVLID 78
Cdd:cd17706    43 HILLVGDPGTAKSQILK----------YVLKIAPRGVYTSGKGSSGAgltaavvrDSETGEWYLEAGAlVLADggVCCID 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575  79 EINRASPKTQSALLEAMQERHVTIE--GDTHKLPDPFLVIATQNPweTEGVFP----------LPETQIDRFSLaISVSY 146
Cdd:cd17706   113 EFDKMKELDRTALHEAMEQQTISIAkaGIVTTLNARCSILAAANP--KGGRYNpklspieninLPSPLLSRFDL-IFVIR 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575 147 PSPDVE----------LSILAKDHELKGLEPKIEPIISKEELLKAIAESSEIH--VEEKIMKYIVEIVRKTREMPEIV-- 212
Cdd:cd17706   190 DDPDEErdeelaehiiDLHRGSDPEEQVKPEEDGIPIDIELLRKYILYARQIHpkISEEAREKLVRWYVELRKESERRst 269

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1491196575 213 LGVSPRTSVILLRTAKALAAIRGRKYVIPDDIK 245
Cdd:cd17706   270 IPITARQLESVIRLAEAHAKMRLSEVVTEEDVE 302
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 5-146 9.02e-10

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 56.39  E-value: 9.02e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575   5 LLSRGHMLIEGPPGTAKTLMAKLFAEAL---GLTFKRIQMtPDMIPADIIGAKIIDPKTGDLRLVLGPIFANIVLIDEIN 81
Cdd:cd00009    16 LPPPKNLLLYGPPGTGKTTLARAIANELfrpGAPFLYLNA-SDLLEGLVVAELFGHFLVRLLFELAEKAKPGVLFIDEID 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1491196575  82 RASPKTQSALLEAMQERHvtiegDTHKLPDPFLVIATQNPWEtegVFPLPETQIDRFSLAISVSY 146
Cdd:cd00009    95 SLSRGAQNALLRVLETLN-----DLRIDRENVRVIGATNRPL---LGDLDRALYDRLDIRIVIPL 151
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 11-138 9.78e-10

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 55.68  E-value: 9.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575  11 MLIEGPPGTAKTLMAKLFAEALGLTFKRIQMtPDMIPadiigaKIIDPKTGDLRLVLGPIFAN---IVLIDEINRASPK- 86
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISG-SELVS------KYVGESEKRLRELFEAAKKLapcVIFIDEIDALAGSr 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1491196575  87 ----------TQSALLEAMqerhvtiEGDTHKLPDPFLVIATQNPWEtegvfpLPETQIDRF 138
Cdd:pfam00004  74 gsggdsesrrVVNQLLTEL-------DGFTSSNSKVIVIAATNRPDK------LDPALLGRF 122
MCM_arch cd17761
archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the ...
 8-245 5.06e-08

archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the eukaryotic Mcm2-7 helicase and also function as the replicative helicase at the replication fork


Pssm-ID: 350667 [Multi-domain]  Cd Length: 308  Bit Score: 53.22  E-value: 5.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575   8 RG--HMLIEGPPGTAKTLMAKLFAealgltfkriQMTPDMI--------PADIIGAKIIDPKTGDLRLVLGPIF---ANI 74
Cdd:cd17761    40 RGdiHILLVGDPGTAKSQLLKYVS----------KVAPRAVyttgkgstAAGLTAAVVRDEGTGEWYLEAGALVladKGI 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575  75 VLIDEINRASPKTQSALLEAMQERHVTIE--GDTHKLPDPFLVIATQNP----WETEGVFP----LPETQIDRFSLaISV 144
Cdd:cd17761   110 AVVDEIDKMRKEDRSALHEAMEQQTISIAkaGIVATLNARAAVLAAANPkfgrFDSYRPVAeqidLPPTLLSRFDL-IFV 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575 145 SYPSPDVELSILAKDHELK----GLEPKIEPIISKEELLKAIAESS-------EIHVEEKIMKYIVEIvRKTREMPEIVL 213
Cdd:cd17761   189 LKDTPNEEKDRRLANHILDthsgGEMREIKPEIDPDLLRKYIAYARknvrpvlTEEAKQLIKDFYVEM-RKSGQETPSPV 267

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1491196575 214 GVSPRTSVILLRTAKALAAIRGRKYVIPDDIK 245
Cdd:cd17761   268 PITARQLEALVRLSEASARMRLSQEVTLEDAE 299
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 6-120 8.09e-07

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 48.05  E-value: 8.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575   6 LSRGHMLIeGPPGTAKTLMAKLFAEALGLTFKRIQmtpdmipadiiGAKIIDPKTGDLRLVLGPIFAN-------IVLID 78
Cdd:cd19481    25 LPKGILLY-GPPGTGKTLLAKALAGELGLPLIVVK-----------LSSLLSKYVGESEKNLRKIFERarrlapcILFID 92

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1491196575  79 EINRASPKTQSALLEAMQERHVT-----IEGDTHKlpDPFLVIATQN 120
Cdd:cd19481    93 EIDAIGRKRDSSGESGELRRVLNqllteLDGVNSR--SKVLVIAATN 137
RuvB_N pfam05496
Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the ...
 10-118 1.48e-06

Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the RuvABC revolvasome which catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalyzed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein. This family contains the N-terminal region of the protein.


Pssm-ID: 398900 [Multi-domain]  Cd Length: 159  Bit Score: 47.11  E-value: 1.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575  10 HMLIEGPPGTAKTLMAKLFAEALGLTFKriqmtpdmipadIIGAKIIDpKTGDLRLVLGPIFANIVL-IDEINRASPKTQ 88
Cdd:pfam05496  35 HVLLYGPPGLGKTTLANIIANEMGVNIR------------ITSGPAIE-RPGDLAAILTNLEPGDVLfIDEIHRLNRAVE 101

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1491196575  89 SALLEAMQERHVTI---EGD---THKLP-DPF-LVIAT 118
Cdd:pfam05496 102 EILYPAMEDFRLDIvigKGPsarSIRLDlPPFtLVGAT 139
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 8-187 2.44e-06

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 48.37  E-value: 2.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575   8 RGHMLIEGPPGTAKTLMAKLFAEALGLTFKRIQmtpdmiPADIIG----------AKIIDpktgdlrLVLGPIFAnIVLI 77
Cdd:COG0464   191 PRGLLLYGPPGTGKTLLARALAGELGLPLIEVD------LSDLVSkyvgeteknlREVFD-------KARGLAPC-VLFI 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575  78 DEI-----NRASPKTQ------SALLEAMQErhvtiegdthkLPDPFLVIATQNpwetegvfpLPEtQID-----RFSLA 141
Cdd:COG0464   257 DEAdalagKRGEVGDGvgrrvvNTLLTEMEE-----------LRSDVVVIAATN---------RPD-LLDpallrRFDEI 315

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1491196575 142 ISVSYPSPDVELSILakDHELKGLEpkiepiISKEELLKAIAESSE 187
Cdd:COG0464   316 IFFPLPDAEERLEIF--RIHLRKRP------LDEDVDLEELAEATE 353
bpMoxR pfam20030
MoxR domain in the MoxR-vWA-beta-propeller ternary systems; Core MoxR component domain of the ...
 1-178 7.12e-06

MoxR domain in the MoxR-vWA-beta-propeller ternary systems; Core MoxR component domain of the MoxR-vWA-beta-propeller ternary systems, a class of NTP-dependent biological conflict systems.


Pssm-ID: 437862 [Multi-domain]  Cd Length: 205  Bit Score: 45.69  E-value: 7.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575   1 MTVTLLSRGHMLIEGPPGTAKTLMAKLFAEALGLTFKRIQMTPDMIPADIIGA-KIIDPKTGDLRLVLGPIF--ANIVLI 77
Cdd:pfam20030  24 LGLALVARENLFLLGPPGTAKSALVRRLAARLGGRYFEYLLTRFTEPNELFGPfDIRKLREGELVTNTEGMLpeASLVFL 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575  78 DEINRASPKTQSALLEAMQERHVTIEGDTHKLPdPFLVIATQNpwetegvfPLPETQ-----IDRFSLAISVSYPSPDVE 152
Cdd:pfam20030 104 DELFNANSAILNSLLMVLNERIFRRGKETRKLP-ALMFVGASN--------HLPEDEalaalFDRFLLRVKCDNVPPDQL 174

                         170       180
                  ....*....|....*....|....*.
gi 1491196575 153 LSILAKDHELKGLEPKIEPIISKEEL 178
Cdd:pfam20030 175 EAVLAAGWKLERRPVTTRPSIAAAEI 200
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 7-126 3.44e-05

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 43.13  E-value: 3.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575    7 SRGHMLIEGPPGTAKTLMAKLFAEALGLTFKRI------QMTPDMIPADIIGAKIIDPKTGDLRLVLGPIFAN------- 73
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPGGGViyidgeDILEEVLDQLLLIIVGGKKASGSGELRLRLALALarklkpd 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1491196575   74 IVLIDEINRASPKTQSALLEAMQERHVTIEgdtHKLPDPFLVIATQNPWETEG 126
Cdd:smart00382  81 VLILDEITSLLDAEQEALLLLLEELRLLLL---LKSEKNLTVILTTNDEKDLG 130
McrB COG1401
5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB ...
 3-83 3.60e-05

5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB [Defense mechanisms];


Pssm-ID: 441011 [Multi-domain]  Cd Length: 477  Bit Score: 44.76  E-value: 3.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575   3 VTLLSRGHMLI-EGPPGTAKTLMAKLFAEALGLT----FKRIQMTPDMI-PADIIGAKiidPKTGDLRLVLGP-IFANI- 74
Cdd:COG1401   215 LAALKTKKNVIlAGPPGTGKTYLARRLAEALGGEdngrIEFVQFHPSWSyEDFLLGYR---PSLDEGKYEPTPgIFLRFc 291

                          90       100
                  ....*....|....*....|.
gi 1491196575  75 ------------VLIDEINRA 83
Cdd:COG1401   292 lkaeknpdkpyvLIIDEINRA 312
AAA_2 pfam07724
AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected ...
 12-92 3.99e-05

AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400187 [Multi-domain]  Cd Length: 168  Bit Score: 43.34  E-value: 3.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575  12 LIEGPPGTAKTLMAKLFAEALGL---TFKRIQMTPDMI----------PADIIGAKiidpKTGDLRLVLGPIFANIVLID 78
Cdd:pfam07724   7 LFLGPTGVGKTELAKALAELLFGderALIRIDMSEYMEehsvsrligaPPGYVGYE----EGGQLTEAVRRKPYSIVLID 82

                          90
                  ....*....|....
gi 1491196575  79 EINRASPKTQSALL 92
Cdd:pfam07724  83 EIEKAHPGVQNDLL 96
Mcm2 COG1241
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
 8-234 1.59e-04

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 42.86  E-value: 1.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575   8 RG--HMLIEGPPGTAKTLMAKlFAEAL---------------GLTfkriqmtpdmipadiigAKII--DPKTGD--LR-- 64
Cdd:COG1241   313 RGdiHILLVGDPGTAKSQLLR-YAARLaprgvytsgkgstaaGLT-----------------AAAVrdDFGTGRwtLEag 374

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575  65 -LVLgpifAN--IVLIDEINRASPKTQSALLEAMQERHVTIE--GDTHKLPDPFLVIATQNP----WETEGVFP----LP 131
Cdd:COG1241   375 aLVL----ADggLACIDELDKMREEDRSALHEAMEQQTISIAkaGIVATLNARCSVLAAANPkygrFDPYEPIAeqidLP 450

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575 132 ETQIDRFSLaISVSYPSPDVEL------SIL-------AKDHELKGLEPKIEPIISKEELLKAIAE---------SSEih 189
Cdd:COG1241   451 PTLLSRFDL-IFVLRDKPDEERdrelarHILkvhrageLLEQEIEEETEEVKPEIDPDLLRKYIAYarrnvfpvlTEE-- 527

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1491196575 190 VEEKIMKYIVEIvRKTREMPEIVLGVSPRTSVILLRTAKALAAIR 234
Cdd:COG1241   528 AKDLIEDFYVDM-RKKGEDEDSPVPITARQLEALIRLAEASARMR 571
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 8-86 2.95e-04

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 40.74  E-value: 2.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575   8 RGhMLIEGPPGTAKTLMAKLFAEALGLTFkriqmtpdmipADIIGAKIIDPKTGDLRLVLGPIFAN-------IVLIDEI 80
Cdd:cd19503    35 RG-VLLHGPPGTGKTLLARAVANEAGANF-----------LSISGPSIVSKYLGESEKNLREIFEEarshapsIIFIDEI 102


                  ....*.
gi 1491196575  81 NRASPK 86
Cdd:cd19503   103 DALAPK 108
ruvB PRK00080
Holliday junction branch migration DNA helicase RuvB;
10-118 3.36e-04

Holliday junction branch migration DNA helicase RuvB;


Pssm-ID: 234619 [Multi-domain]  Cd Length: 328  Bit Score: 41.65  E-value: 3.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575  10 HMLIEGPPGTAKTLMAKLFAEALGLTFKriqmtpdmipadIIGAKIIDpKTGDLRLVLGPIFANIVL-IDEINRASPKTQ 88
Cdd:PRK00080   53 HVLLYGPPGLGKTTLANIIANEMGVNIR------------ITSGPALE-KPGDLAAILTNLEEGDVLfIDEIHRLSPVVE 119

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1491196575  89 SALLEAMQERHVTI---EGDTHK-----LPdPF-LVIAT 118
Cdd:PRK00080  120 EILYPAMEDFRLDImigKGPAARsirldLP-PFtLIGAT 157
MCM7 cd17758
DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in ...
 53-244 4.40e-04

DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350664 [Multi-domain]  Cd Length: 306  Bit Score: 41.24  E-value: 4.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575  53 AKIIDPKTGDLRLVLGP-IFAN--IVLIDEINRASPKTQSALLEAMQERHVTIE--GDTHKLPDPFLVIATQNP----WE 123
Cdd:cd17758    83 AVMKDPVTGEMTLEGGAlVLADqgICCIDEFDKMDESDRTAIHEVMEQQTISIAkaGITTTLNARTSILAAANPaygrYN 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575 124 ----TEGVFPLPETQIDRFS---LAISVSYPSPDVELSILAKDHELKGLEPKIE-PIISKEELLKAIAESSEIH--VEEK 193
Cdd:cd17758   163 prrsPEQNINLPAALLSRFDllfLILDKPDRDNDLRLAEHVTYVHQHNKQPDSDfEPLDPKLLRAYIALAKRKRptVPPA 242

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1491196575 194 IMKYIVEI---VRKTREMPEIVLGVSPRTSVILLRTAKALAAIRGRKYVIPDDI 244
Cdd:cd17758   243 LADYIVQAyveMRQEAKRSKDFTFTTPRTLLAILRLSQALARLRLSDSVEIDDV 296
MCM pfam00493
MCM P-loop domain;
8-121 9.31e-04

MCM P-loop domain;


Pssm-ID: 459830 [Multi-domain]  Cd Length: 224  Bit Score: 39.82  E-value: 9.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575   8 RG--HMLIEGPPGTAKTLMAKL--------------FAEALGLTfkriqmtpdmipadiiGAKIIDPKTGDLRLVLGP-I 70
Cdd:pfam00493  55 RGdiNVLLVGDPGTAKSQLLKYvekiapravytsgkGSSAAGLT----------------AAVVRDPVTGEFVLEAGAlV 118

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1491196575  71 FAN--IVLIDEINRASPKTQSALLEAMQERHVTIE--GDTHKLPDPFLVIATQNP 121
Cdd:pfam00493 119 LADggVCCIDEFDKMNDEDRVALHEAMEQQTISIAkaGIVATLNARCSILAAANP 173
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
8-202 1.68e-03

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 39.10  E-value: 1.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575   8 RGHMLIEGPPGTAKTLMAKLFAEALGLTFKRIQMTpdmipadiigaKIIDPKTGD----LRLVLGpiFAN----IVLIDE 79
Cdd:COG1223    35 PRKILFYGPPGTGKTMLAEALAGELKLPLLTVRLD-----------SLIGSYLGEtarnLRKLFD--FARrapcVIFFDE 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575  80 IN-----RASP-------KTQSALLEAMQErhvtiegdthkLPDPFLVIATQNpwetegvfpLPEtQID-----RFSLAI 142
Cdd:COG1223   102 FDaiakdRGDQndvgevkRVVNALLQELDG-----------LPSGSVVIAATN---------HPE-LLDsalwrRFDEVI 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1491196575 143 SVSYPSPD-----VELSI----LAKDHELKGLEPKIEPI--ISKEELLKAIAESSEIHVEEKIMKYIVEIV 202
Cdd:COG1223   161 EFPLPDKEerkeiLELNLkkfpLPFELDLKKLAKKLEGLsgADIEKVLKTALKKAILEDREKVTKEDLEEA 231
chlI CHL00081
Mg-protoporyphyrin IX chelatase
 225-277 2.06e-03

Mg-protoporyphyrin IX chelatase


Pssm-ID: 177020 [Multi-domain]  Cd Length: 350  Bit Score: 39.20  E-value: 2.06e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1491196575 225 RTAKALAAIRGRKYVIPDDIKYLTPYVLWHRIKLSPR--IASFITPEEKYTKIVS 277
Cdd:CHL00081  296 RAAKALAAFEGRTEVTPKDIFKVITLCLRHRLRKDPLesIDSGDKVQKVFKEVFG 350
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 7-101 2.06e-03

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 38.15  E-value: 2.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575   7 SRGhMLIEGPPGTAKTLMAKLFAEALGLTFKRIQMTpdmipadiigaKIIDPKTGDLRLVLGPIFAN-------IVLIDE 79
Cdd:cd19518    34 PRG-VLLHGPPGCGKTMLANAIAGELKVPFLKISAT-----------EIVSGVSGESEEKIRELFDQaisnapcIVFIDE 101

                          90       100
                  ....*....|....*....|..
gi 1491196575  80 INRASPKTQSALLEaMQERHVT 101
Cdd:cd19518   102 IDAITPKRESAQRE-MERRIVS 122
MCM smart00350
minichromosome maintenance proteins;
8-244 2.56e-03

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 39.17  E-value: 2.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575    8 RG--HMLIEGPPGTAKTLMAKLF--------------AEALGLTfkriqmtpdmipadiiGAKIIDPKTGDLRLVLGP-I 70
Cdd:smart00350 234 RGdiNILLCGDPGTAKSQLLKYVektapravyttgkgSSAVGLT----------------AAVTRDPETREFTLEAGAlV 297

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575   71 FAN--IVLIDEINRASPKTQSALLEAMQERHVTIE--GDTHKLPDPFLVIATQNPWE---------TEGVfPLPETQIDR 137
Cdd:smart00350 298 LADngVCCIDEFDKMDDSDRTAIHEAMEQQTISIAkaGITTTLNARCSVLAAANPIGgrydpkltpEENI-DLPAPILSR 376

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575  138 FSLA-ISVSYPSPDVELSiLAKD----HELKGLEP--KIEPIISKEELLKAIAESSE-IH--VEEKIMKYIVEIVRKTRE 207
Cdd:smart00350 377 FDLLfVVLDEVDEERDRE-LAKHvvdlHRYSHPEEdeAFEPPLSQEKLRKYIAYAREkIKpkLSEEAADKLVKAYVDLRK 455

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|..
gi 1491196575  208 MPEIVLGVS-----PRTSVILLRTAKALAAIRGRKYVIPDDI 244
Cdd:smart00350 456 EDSQTESRSsipitVRQLESIIRLSEAHAKMRLSDVVEEADV 497
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 11-236 3.35e-03

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 38.73  E-value: 3.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575  11 MLIEGPPGTAKTLMAKLFAEALGLTFKRIQmtpdmipadiiGAKIIDPKTGDLRLVLGPIFAN-------IVLIDEINRA 83
Cdd:TIGR01243 490 VLLFGPPGTGKTLLAKAVATESGANFIAVR-----------GPEILSKWVGESEKAIREIFRKarqaapaIIFFDEIDAI 558

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575  84 SPKTQSALLEAMQERHVT---IEGDTHKLPDPFLVIATQNPWETEGVFPLPETQIDRFSLAisvsyPSPDVELSI----- 155
Cdd:TIGR01243 559 APARGARFDTSVTDRIVNqllTEMDGIQELSNVVVIAATNRPDILDPALLRPGRFDRLILV-----PPPDEEARKeifki 633

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575 156 ------LAKDHELKGLEPKIE-------PIISKEELLKAIAESSEIHVEEKIMKYIVEIVRKT----REMPEIVLGVSPR 218
Cdd:TIGR01243 634 htrsmpLAEDVDLEELAEMTEgytgadiEAVCREAAMAALRESIGSPAKEKLEVGEEEFLKDLkvemRHFLEALKKVKPS 713

                         250
                  ....*....|....*...
gi 1491196575 219 TSVILLRTAKALAAIRGR 236
Cdd:TIGR01243 714 VSKEDMLRYERLAKELKR 731
MCM3 cd17754
DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in ...
 8-245 3.73e-03

DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350660 [Multi-domain]  Cd Length: 299  Bit Score: 38.22  E-value: 3.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575   8 RG--HMLIEGPPGTAKTLMAKLFaealgltfkrIQMTPDMIPAD--------IIGAKIIDPKTGDLRLVLGP-IFAN--I 74
Cdd:cd17754    39 RGdiNILLVGDPSVAKSQLLRYV----------LNTAPLAIATTgrgssgvgLTAAVTTDQETGERRLEAGAmVLADrgV 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575  75 VLIDEINRASPKTQSALLEAMQERHVTIE--GDTHKLPDPFLVIATQNPW---------ETEGVFpLPETQIDRFSLaIS 143
Cdd:cd17754   109 VCIDEFDKMSDIDRVAIHEVMEQQTVTIAkaGIHASLNARCSVLAAANPVygrydvyktPMENIG-LPDSLLSRFDL-LF 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575 144 VSYPSPDVELSILAKDHELKG-------------LEPKIEPIISkEELLKAIAESSEIHVEEKIMKYIVEivrktREMPe 210
Cdd:cd17754   187 IVLDDIDEERDRSISEHVLRMhryikflrkyihyAKERIKPKLT-QEAAEYIAEEYADLRNDDNTKTDKA-----RTSP- 259

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1491196575 211 ivlgVSPRTSVILLRTAKALAAIRGRKYVIPDDIK 245
Cdd:cd17754   260 ----ITARTLETLIRLATAHAKARLSKTVDKVDAE 290
bchD PRK13406
magnesium chelatase subunit D; Provisional
 82-255 4.44e-03

magnesium chelatase subunit D; Provisional


Pssm-ID: 237378 [Multi-domain]  Cd Length: 584  Bit Score: 38.47  E-value: 4.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575  82 RASPKTQSALLEAMQERHVTIEGDTHKLPDP--FLVIATQnpwetEGVFP---LPETQIDRfsLAISVsypspdvELSIL 156
Cdd:PRK13406  104 RLEPGTAARLAAALDTGEVRLERDGLALRLParFGLVALD-----EGAEEderAPAALADR--LAFHL-------DLDGL 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575 157 AkDHELKGLEPKIEPIISKEELLKAIAESSEIHVEekimkyIVEIVRktrempeiVLGV-SPRTSVILLRTAKALAAIRG 235
Cdd:PRK13406  170 A-LRDAREIPIDADDIAAARARLPAVGPPPEAIAA------LCAAAA--------ALGIaSLRAPLLALRAARAAAALAG 234

                         170       180
                  ....*....|....*....|
gi 1491196575 236 RKYVIPDDIKYLTPYVLWHR 255
Cdd:PRK13406  235 RTAVEEEDLALAARLVLAPR 254
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 12-244 5.44e-03

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 37.68  E-value: 5.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575  12 LIEGPPGTAKTLMAKLFAEALGLTFKRiqmtpdMIPADII------GAKIIdpktgdlRLVlgpiFAN-------IVLID 78
Cdd:COG1222   116 LLYGPPGTGKTLLAKAVAGELGAPFIR------VRGSELVskyigeGARNV-------REV----FELarekapsIIFID 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575  79 EI-----NRASPKT-------QSALLEAMQErhvtIEGDthklpDPFLVIATQN-PWEtegvfplpetqID-------RF 138
Cdd:COG1222   179 EIdaiaaRRTDDGTsgevqrtVNQLLAELDG----FESR-----GDVLIIAATNrPDL-----------LDpallrpgRF 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575 139 SLAISVSYPSPDVELSILAKdHeLKGLEpkiepiISKEELLKAIAESSEihveekimkyiveivrktrempeivlGVSPR 218
Cdd:COG1222   239 DRVIEVPLPDEEAREEILKI-H-LRDMP------LADDVDLDKLAKLTE--------------------------GFSGA 284

                         250       260
                  ....*....|....*....|....*.
gi 1491196575 219 TSVILLRTAKALAAIRGRKYVIPDDI 244
Cdd:COG1222   285 DLKAIVTEAGMFAIREGRDTVTMEDL 310
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 15-207 6.23e-03

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 37.83  E-value: 6.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575  15 GPPGTAKTLMAKLFAEALGLTFKRiqmtpdmipadIIGAKIIDPKTGDLRLVLGPIF-------ANIVLIDEINRASPK- 86
Cdd:PTZ00361  224 GPPGTGKTLLAKAVANETSATFLR-----------VVGSELIQKYLGDGPKLVRELFrvaeenaPSIVFIDEIDAIGTKr 292

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575  87 ----------TQSALLEAMQE-------RHVTIEGDTHKLP--DPFLVIATQNPWETEgvFPLPETQIDR--FSLAISVS 145
Cdd:PTZ00361  293 ydatsggekeIQRTMLELLNQldgfdsrGDVKVIMATNRIEslDPALIRPGRIDRKIE--FPNPDEKTKRriFEIHTSKM 370

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1491196575 146 YPSPDVELS--ILAKDhELKGLEpkiepiiskeelLKAI-AESSEIHVEEKIMKYIVEIVRKTRE 207
Cdd:PTZ00361  371 TLAEDVDLEefIMAKD-ELSGAD------------IKAIcTEAGLLALRERRMKVTQADFRKAKE 422
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
 10-36 6.28e-03

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 36.35  E-value: 6.28e-03
                          10        20
                  ....*....|....*....|....*..
gi 1491196575  10 HMLIEGPPGTAKTLMAKLFAEALGLTF 36
Cdd:cd19512    24 NILFYGPPGTGKTLFAKKLALHSGMDY 50
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 12-86 7.41e-03

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 36.49  E-value: 7.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575  12 LIEGPPGTAKTLMAKLFAEALGLTFKRIQmtpdmipadiiGAKIIDPKTGDLRLVLGPIFAN-------IVLIDEINRAS 84
Cdd:cd19511    31 LLYGPPGCGKTLLAKALASEAGLNFISVK-----------GPELFSKYVGESERAVREIFQKarqaapcIIFFDEIDSLA 99


                  ..
gi 1491196575  85 PK 86
Cdd:cd19511   100 PR 101
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 11-93 7.87e-03

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 37.58  E-value: 7.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196575  11 MLIEGPPGTAKTLMAKLFAEALGLTFKRIQmtpdmipadiiGAKIIDPKTGDLRLVLGPIFA-------NIVLIDEINRA 83
Cdd:TIGR01243 215 VLLYGPPGTGKTLLAKAVANEAGAYFISIN-----------GPEIMSKYYGESEERLREIFKeaeenapSIIFIDEIDAI 283

                          90
                  ....*....|
gi 1491196575  84 SPKTQSALLE 93
Cdd:TIGR01243 284 APKREEVTGE 293
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH