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Conserved domains on  [gi|1491196561|gb|RLG76643|]
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MAG: hypothetical protein DRO23_00405 [Thermoprotei archaeon]

Protein Classification

alpha/beta fold hydrolase( domain architecture ID 11426811)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

PubMed:  1409539|12369917

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 7-277 1.65e-58

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


:

Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 185.97  E-value: 1.65e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561   7 PFYIDVGNIKLNVYDSAEkcsyrEKLALIFLHGLPGQISNWKHQVEYFERKYRVIVYDQRGFGASDKPKK-VSLNDYLQD 85
Cdd:COG0596     4 PRFVTVDGVRLHYREAGP-----DGPPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDKPAGgYTLDDLADD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561  86 LDKIIEsrKLNTEDTILIGHSFGGMVAQAYTRTH--KVKGLVLIGSLtkikpdifdkitwylppifwrkilyketpltRR 163
Cdd:COG0596    79 LAALLD--ALGLERVVLVGHSMGGMVALELAARHpeRVAGLVLVDEV-------------------------------LA 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561 164 LYRRIFFSPSTPKEVFEEFIkdnkeylerlpayvfrytRFFIDYDATKWLHEIKVPTLIIVGKDDKVTPVDESKLLNKLI 243
Cdd:COG0596   126 ALAEPLRRPGLAPEALAALL------------------RALARTDLRERLARITVPTLVIWGEKDPIVPPALARRLAELL 187

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1491196561 244 PNSRLIIIEDAGHLVLYEKPSELNGIIEEFIREL 277
Cdd:COG0596   188 PNAELVVLPGAGHFPPLEQPEAFAAALRDFLARL 221
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 7-277 1.65e-58

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 185.97  E-value: 1.65e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561   7 PFYIDVGNIKLNVYDSAEkcsyrEKLALIFLHGLPGQISNWKHQVEYFERKYRVIVYDQRGFGASDKPKK-VSLNDYLQD 85
Cdd:COG0596     4 PRFVTVDGVRLHYREAGP-----DGPPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDKPAGgYTLDDLADD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561  86 LDKIIEsrKLNTEDTILIGHSFGGMVAQAYTRTH--KVKGLVLIGSLtkikpdifdkitwylppifwrkilyketpltRR 163
Cdd:COG0596    79 LAALLD--ALGLERVVLVGHSMGGMVALELAARHpeRVAGLVLVDEV-------------------------------LA 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561 164 LYRRIFFSPSTPKEVFEEFIkdnkeylerlpayvfrytRFFIDYDATKWLHEIKVPTLIIVGKDDKVTPVDESKLLNKLI 243
Cdd:COG0596   126 ALAEPLRRPGLAPEALAALL------------------RALARTDLRERLARITVPTLVIWGEKDPIVPPALARRLAELL 187

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1491196561 244 PNSRLIIIEDAGHLVLYEKPSELNGIIEEFIREL 277
Cdd:COG0596   188 PNAELVVLPGAGHFPPLEQPEAFAAALRDFLARL 221
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 33-263 3.63e-38

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 134.55  E-value: 3.63e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561  33 ALIFLHGLPGQISNWKHQVEYFERK-YRVIVYDQRGFGASDKPK---KVSLNDYLQDLDKIIEsrKLNTEDTILIGHSFG 108
Cdd:pfam00561   2 PVLLLHGLPGSSDLWRKLAPALARDgFRVIALDLRGFGKSSRPKaqdDYRTDDLAEDLEYILE--ALGLEKVNLVGHSMG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561 109 GMVAQAYTRTH--KVKGLVLIGSL-TKIKPDIFDKITWYLPPIFWRKILYKETPLT---------RRLYRRIFFSPSTPk 176
Cdd:pfam00561  80 GLIALAYAAKYpdRVKALVLLGALdPPHELDEADRFILALFPGFFDGFVADFAPNPlgrlvakllALLLLRLRLLKALP- 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561 177 EVFEEFIKDNKEYLERLPAYVFRYTRFFIDYDATKWLHEIKVPTLIIVGKDDKVTPVDESKLLNKLIPNSRLIIIEDAGH 256
Cdd:pfam00561 159 LLNKRFPSGDYALAKSLVTGALLFIETWSTELRAKFLGRLDEPTLIIWGDQDPLVPPQALEKLAQLFPNARLVVIPDAGH 238


                  ....*..
gi 1491196561 257 LVLYEKP 263
Cdd:pfam00561 239 FAFLEGP 245
pro_imino_pep_2 TIGR01250
proline-specific peptidase, Bacillus coagulans-type subfamily; This model describes a ...
 30-275 3.01e-26

proline-specific peptidase, Bacillus coagulans-type subfamily; This model describes a subfamily of the alpha/beta fold family of hydrolases. Characterized members include prolinases (Pro-Xaa dipeptidase, EC 3.4.13.8), prolyl aminopeptidases (EC 3.4.11.5), and a leucyl aminopeptidase


Pssm-ID: 188121 [Multi-domain]  Cd Length: 289  Bit Score: 104.38  E-value: 3.01e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561  30 EKLALIFLHGLPGQISN-WKHQVEYFERKYR-VIVYDQRGFGASDKP-----KKVSLNDYLQDLDKIIEsrKLNTEDTIL 102
Cdd:TIGR01250  24 EKIKLLLLHGGPGMSHEyLENLRELLKEEGReVIMYDQLGCGYSDQPddsdeELWTIDYFVDELEEVRE--KLGLDKFYL 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561 103 IGHSFGGMVAQAYTRTHK--VKGLVLIGSLTKIkpDIFDK----ITWYLPPI---FWRKILYKET-------PLTRRLYR 166
Cdd:TIGR01250 102 LGHSWGGMLAQEYALKYGqhLKGLIISSMLDSA--PEYVKelnrLRKELPPEvraAIKRCEASGDydnpeyqEAVEVFYH 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561 167 RIFFSPSTPKEVFEEfikdnKEYLERLPAYV-------FRYTRFFIDYDATKWLHEIKVPTLIIVGKDDKVTPvDESKLL 239
Cdd:TIGR01250 180 HLLCRLRKWPEALKH-----LKSGGNTNVYNimqgpneFTITGNLKDWDITDKLSEIKVPTLLTVGEFDTMTP-EAAREM 253

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1491196561 240 NKLIPNSRLIIIEDAGHLVLYEKPSELNGIIEEFIR 275
Cdd:TIGR01250 254 QELIAGSRLVVFPDGSHMTMIEDPEVYFKLLSDFIR 289
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 5-275 5.00e-16

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 76.91  E-value: 5.00e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561   5 GKPFYIDVGNIKLNVYDSAEKcsyrEKLALIFLHGLPGQISNWKHQVEYFERKYRVIVYDQRGFGASDkpKKVSLNDyLQ 84
Cdd:PRK14875  109 PAPRKARIGGRTVRYLRLGEG----DGTPVVLIHGFGGDLNNWLFNHAALAAGRPVIALDLPGHGASS--KAVGAGS-LD 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561  85 DLDKIIESR--KLNTEDTILIGHSFGGMVAQAYTRTH--KVKGLVLIGSlTKIKPDIFDKITWYLPPIFWRKILykeTPL 160
Cdd:PRK14875  182 ELAAAVLAFldALGIERAHLVGHSMGGAVALRLAARApqRVASLTLIAP-AGLGPEINGDYIDGFVAAESRREL---KPV 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561 161 TRRLYRriffspsTPKEVFEEFIKDNKEY---------LERLPAYVFRYTRFFIDYDATkwLHEIKVPTLIIVGKDDKVT 231
Cdd:PRK14875  258 LELLFA-------DPALVTRQMVEDLLKYkrldgvddaLRALADALFAGGRQRVDLRDR--LASLAIPVLVIWGEQDRII 328

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1491196561 232 PVDESkllNKLIPNSRLIIIEDAGHLVLYEKPSELNGIIEEFIR 275
Cdd:PRK14875  329 PAAHA---QGLPDGVAVHVLPGAGHMPQMEAAADVNRLLAEFLG 369
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 7-277 1.65e-58

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 185.97  E-value: 1.65e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561   7 PFYIDVGNIKLNVYDSAEkcsyrEKLALIFLHGLPGQISNWKHQVEYFERKYRVIVYDQRGFGASDKPKK-VSLNDYLQD 85
Cdd:COG0596     4 PRFVTVDGVRLHYREAGP-----DGPPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDKPAGgYTLDDLADD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561  86 LDKIIEsrKLNTEDTILIGHSFGGMVAQAYTRTH--KVKGLVLIGSLtkikpdifdkitwylppifwrkilyketpltRR 163
Cdd:COG0596    79 LAALLD--ALGLERVVLVGHSMGGMVALELAARHpeRVAGLVLVDEV-------------------------------LA 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561 164 LYRRIFFSPSTPKEVFEEFIkdnkeylerlpayvfrytRFFIDYDATKWLHEIKVPTLIIVGKDDKVTPVDESKLLNKLI 243
Cdd:COG0596   126 ALAEPLRRPGLAPEALAALL------------------RALARTDLRERLARITVPTLVIWGEKDPIVPPALARRLAELL 187

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1491196561 244 PNSRLIIIEDAGHLVLYEKPSELNGIIEEFIREL 277
Cdd:COG0596   188 PNAELVVLPGAGHFPPLEQPEAFAAALRDFLARL 221
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 33-263 3.63e-38

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 134.55  E-value: 3.63e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561  33 ALIFLHGLPGQISNWKHQVEYFERK-YRVIVYDQRGFGASDKPK---KVSLNDYLQDLDKIIEsrKLNTEDTILIGHSFG 108
Cdd:pfam00561   2 PVLLLHGLPGSSDLWRKLAPALARDgFRVIALDLRGFGKSSRPKaqdDYRTDDLAEDLEYILE--ALGLEKVNLVGHSMG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561 109 GMVAQAYTRTH--KVKGLVLIGSL-TKIKPDIFDKITWYLPPIFWRKILYKETPLT---------RRLYRRIFFSPSTPk 176
Cdd:pfam00561  80 GLIALAYAAKYpdRVKALVLLGALdPPHELDEADRFILALFPGFFDGFVADFAPNPlgrlvakllALLLLRLRLLKALP- 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561 177 EVFEEFIKDNKEYLERLPAYVFRYTRFFIDYDATKWLHEIKVPTLIIVGKDDKVTPVDESKLLNKLIPNSRLIIIEDAGH 256
Cdd:pfam00561 159 LLNKRFPSGDYALAKSLVTGALLFIETWSTELRAKFLGRLDEPTLIIWGDQDPLVPPQALEKLAQLFPNARLVVIPDAGH 238


                  ....*..
gi 1491196561 257 LVLYEKP 263
Cdd:pfam00561 239 FAFLEGP 245
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
33-276 6.15e-32

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 117.41  E-value: 6.15e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561  33 ALIFLHGLPGQISNWKHQVEYF-ERKYRVIVYDQRGFGASDKPK--KVSLNDYLQDLDKIIES-RKLNTEDTILIGHSFG 108
Cdd:COG2267    30 TVVLVHGLGEHSGRYAELAEALaAAGYAVLAFDLRGHGRSDGPRghVDSFDDYVDDLRAALDAlRARPGLPVVLLGHSMG 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561 109 GMVAQAYTRTH--KVKGLVLIGsltkikpdifdkitwylpPIFWRKILYKETPltrrlyrriffspstpkevfeefikdn 186
Cdd:COG2267   110 GLIALLYAARYpdRVAGLVLLA------------------PAYRADPLLGPSA--------------------------- 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561 187 keylerlpayvfrytRFFIDYDATKWLHEIKVPTLIIVGKDDKVTPVDES-KLLNKLIPNSRLIIIEDAGHLVLYEKP-S 264
Cdd:COG2267   145 ---------------RWLRALRLAEALARIDVPVLVLHGGADRVVPPEAArRLAARLSPDVELVLLPGARHELLNEPArE 209

                         250
                  ....*....|..
gi 1491196561 265 ELNGIIEEFIRE 276
Cdd:COG2267   210 EVLAAILAWLER 221
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 31-262 5.77e-27

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 104.99  E-value: 5.77e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561  31 KLALIFLHGLPGQISNWKHQVEYF-ERKYRVIVYDQRGFGASDkPKKV---SLNDYLQDLDKIIESRKLNTEDT--ILIG 104
Cdd:pfam12146   4 RAVVVLVHGLGEHSGRYAHLADALaAQGFAVYAYDHRGHGRSD-GKRGhvpSFDDYVDDLDTFVDKIREEHPGLplFLLG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561 105 HSFGGMVAQAYTRTH--KVKGLVLIGSLTKIKPDifdKITWYLppIFWRKILYKETPLTRRLYRRIFFSPSTPKEVFEEF 182
Cdd:pfam12146  83 HSMGGLIAALYALRYpdKVDGLILSAPALKIKPY---LAPPIL--KLLAKLLGKLFPRLRVPNNLLPDSLSRDPEVVAAY 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561 183 IKDnKEYLERLPAyvfrytRFFID-YDATKWL----HEIKVPTLIIVGKDDKVTPVDESKLLNKLIPNS--RLIIIEDAG 255
Cdd:pfam12146 158 AAD-PLVHGGISA------RTLYElLDAGERLlrraAAITVPLLLLHGGADRVVDPAGSREFYERAGSTdkTLKLYPGLY 230


                  ....*..
gi 1491196561 256 HLVLYEK 262
Cdd:pfam12146 231 HELLNEP 237
pro_imino_pep_2 TIGR01250
proline-specific peptidase, Bacillus coagulans-type subfamily; This model describes a ...
 30-275 3.01e-26

proline-specific peptidase, Bacillus coagulans-type subfamily; This model describes a subfamily of the alpha/beta fold family of hydrolases. Characterized members include prolinases (Pro-Xaa dipeptidase, EC 3.4.13.8), prolyl aminopeptidases (EC 3.4.11.5), and a leucyl aminopeptidase


Pssm-ID: 188121 [Multi-domain]  Cd Length: 289  Bit Score: 104.38  E-value: 3.01e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561  30 EKLALIFLHGLPGQISN-WKHQVEYFERKYR-VIVYDQRGFGASDKP-----KKVSLNDYLQDLDKIIEsrKLNTEDTIL 102
Cdd:TIGR01250  24 EKIKLLLLHGGPGMSHEyLENLRELLKEEGReVIMYDQLGCGYSDQPddsdeELWTIDYFVDELEEVRE--KLGLDKFYL 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561 103 IGHSFGGMVAQAYTRTHK--VKGLVLIGSLTKIkpDIFDK----ITWYLPPI---FWRKILYKET-------PLTRRLYR 166
Cdd:TIGR01250 102 LGHSWGGMLAQEYALKYGqhLKGLIISSMLDSA--PEYVKelnrLRKELPPEvraAIKRCEASGDydnpeyqEAVEVFYH 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561 167 RIFFSPSTPKEVFEEfikdnKEYLERLPAYV-------FRYTRFFIDYDATKWLHEIKVPTLIIVGKDDKVTPvDESKLL 239
Cdd:TIGR01250 180 HLLCRLRKWPEALKH-----LKSGGNTNVYNimqgpneFTITGNLKDWDITDKLSEIKVPTLLTVGEFDTMTP-EAAREM 253

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1491196561 240 NKLIPNSRLIIIEDAGHLVLYEKPSELNGIIEEFIR 275
Cdd:TIGR01250 254 QELIAGSRLVVFPDGSHMTMIEDPEVYFKLLSDFIR 289
protocat_pcaD TIGR02427
3-oxoadipate enol-lactonase; Members of this family are 3-oxoadipate enol-lactonase. Note that ...
 30-275 4.86e-23

3-oxoadipate enol-lactonase; Members of this family are 3-oxoadipate enol-lactonase. Note that the substrate is known as 3-oxoadipate enol-lactone, 2-oxo-2,3-dihydrofuran-5-acetate, 4,5-Dihydro-5-oxofuran-2-acetate, and 5-oxo-4,5-dihydrofuran-2-acetate. The enzyme the catalyzes the fourth step in the protocatechuate degradation to beta-ketoadipate and then to succinyl-CoA and acetyl-CoA. 4-hydroxybenzoate, 3-hydroxybenzoate, and vanillate all can be converted in one step to protocatechuate. This enzyme also acts in catechol degradation. In genomes that catabolize both catechol and protocatechuate, two forms of this enzyme may be found. All members of the seed alignment for this model were chosen from within protocatechuate degradation operons of at least three genes of the pathway, from genomes with the complete pathway through beta-ketoadipate. [Energy metabolism, Other]


Pssm-ID: 131480 [Multi-domain]  Cd Length: 251  Bit Score: 94.73  E-value: 4.86e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561  30 EKLALIFLHGLPGQISNWKHQVEYFERKYRVIVYDQRGFGASDKPK-KVSLNDYLQDLDKIIESrkLNTEDTILIGHSFG 108
Cdd:TIGR02427  12 GAPVLVFINSLGTDLRMWDPVLPALTPDFRVLRYDKRGHGLSDAPEgPYSIEDLADDVLALLDH--LGIERAVFCGLSLG 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561 109 GMVAQ--AYTRTHKVKGLVLIGSLTKIKpdifDKITWYlPPIfwRKILYK------ETPLTRrlyrriFFSPStpkevfe 180
Cdd:TIGR02427  90 GLIAQglAARRPDRVRALVLSNTAAKIG----TPESWN-ARI--AAVRAEglaalaDAVLER------WFTPG------- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561 181 efikdnkeYLERLPAYVFRYTRFFI---------------DYDATKWLHEIKVPTLIIVGKDDKVTPVDESKLLNKLIPN 245
Cdd:TIGR02427 150 --------FREAHPARLDLYRNMLVrqppdgyagccaairDADFRDRLGAIAVPTLCIAGDQDGSTPPELVREIADLVPG 221

                         250       260       270
                  ....*....|....*....|....*....|
gi 1491196561 246 SRLIIIEDAGHLVLYEKPSELNGIIEEFIR 275
Cdd:TIGR02427 222 ARFAEIRGAGHIPCVEQPEAFNAALRDFLR 251
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
33-276 2.27e-20

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 86.99  E-value: 2.27e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561  33 ALIFLHGLPGQISN-WKHQVEYFERK-YRVIVYDQRGFGASDK-PKKVSLNDYLQDLDKIIESRKLNTEDTILIGHSFGG 109
Cdd:COG1506    25 VVVYVHGGPGSRDDsFLPLAQALASRgYAVLAPDYRGYGESAGdWGGDEVDDVLAAIDYLAARPYVDPDRIGIYGHSYGG 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561 110 MVAQ--AYTRTHKVKGLVLIGSltkikpdIFDKITWYlppifwrkilyketPLTRRLYRRIFFSPSTPKEVFEEfikdnk 187
Cdd:COG1506   105 YMALlaAARHPDRFKAAVALAG-------VSDLRSYY--------------GTTREYTERLMGGPWEDPEAYAA------ 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561 188 eylerlpayvfrytrffidYDATKWLHEIKVPTLIIVGKDDKVTPVDES-KLLNKLI---PNSRLIIIEDAGHLVLYEKP 263
Cdd:COG1506   158 -------------------RSPLAYADKLKTPLLLIHGEADDRVPPEQAeRLYEALKkagKPVELLVYPGEGHGFSGAGA 218

                         250
                  ....*....|...
gi 1491196561 264 SELNGIIEEFIRE 276
Cdd:COG1506   219 PDYLERILDFLDR 231
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 33-276 2.70e-20

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 87.28  E-value: 2.70e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561  33 ALIFLHGLPGQISNWKHQVEYF-ERKYRVIVYDQRGFGASD-KPKKVSL---NDYLQDLDKIIESRKLNTEDTILIGHSF 107
Cdd:COG1073    39 AVVVAHGNGGVKEQRALYAQRLaELGFNVLAFDYRGYGESEgEPREEGSperRDARAAVDYLRTLPGVDPERIGLLGISL 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561 108 GGMVAQAYTRTHK-VKGLVLIGSLTKIkPDIFDKITWYLPPIFWRKILYKetpltrrlyrriffspstPKEVFEEFIKDn 186
Cdd:COG1073   119 GGGYALNAAATDPrVKAVILDSPFTSL-EDLAAQRAKEARGAYLPGVPYL------------------PNVRLASLLND- 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561 187 keylerlpayvfrytrffiDYDATKWLHEIKVPTLIIVGKDDKVTPVDESKLLNKLIP-NSRLIIIEDAGHLVLYEKP-S 264
Cdd:COG1073   179 -------------------EFDPLAKIEKISRPLLFIHGEKDEAVPFYMSEDLYEAAAePKELLIVPGAGHVDLYDRPeE 239

                         250
                  ....*....|..
gi 1491196561 265 ELNGIIEEFIRE 276
Cdd:COG1073   240 EYFDKLAEFFKK 251
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 34-261 5.31e-19

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 82.91  E-value: 5.31e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561  34 LIFLHGLPGQISNWkhqVEYFERKYRVIVYDQRGFGASDKPKkVSLNDyLQDLDKIIESRKlNTEDTILIGHSFGGMVAQ 113
Cdd:pfam12697   1 VVLVHGAGLSAAPL---AALLAAGVAVLAPDLPGHGSSSPPP-LDLAD-LADLAALLDELG-AARPVVLVGHSLGGAVAL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561 114 AYTRTHKVKGlVLIGSLTKIKPDIFDKITWYLppifwrkilyketPLTRRLYRRIFFSPSTPKEVFEEFIKDNKEYLERL 193
Cdd:pfam12697  75 AAAAAALVVG-VLVAPLAAPPGLLAALLALLA-------------RLGAALAAPAWLAAESLARGFLDDLPADAEWAAAL 140

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1491196561 194 PAYVfRYTRFFIDYDATKWlHEIKVPTLIIVGKDDKVTPVDESKLlnKLIPNSRLIIIEDAGHLVLYE 261
Cdd:pfam12697 141 ARLA-ALLAALALLPLAAW-RDLPVPVLVLAEEDRLVPELAQRLL--AALAGARLVVLPGAGHLPLDD 204
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
33-277 3.46e-18

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 81.53  E-value: 3.46e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561  33 ALIFLHGLPGQISNWKHQVEYFERK-YRVIVYDQRGFGAS-DKPKKVSLNDYLQDLDKIIESRKLNTEDTILIGHSFGGM 110
Cdd:COG1647    17 GVLLLHGFTGSPAEMRPLAEALAKAgYTVYAPRLPGHGTSpEDLLKTTWEDWLEDVEEAYEILKAGYDKVIVIGLSMGGL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561 111 VAQAYTRTHK-VKGLVLIGsltkikpdifdkitwylPPIFWRKILYKETPLTRRLYRRIFFSPSTPKEvfeefIKDNKEY 189
Cdd:COG1647    97 LALLLAARYPdVAGLVLLS-----------------PALKIDDPSAPLLPLLKYLARSLRGIGSDIED-----PEVAEYA 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561 190 LERLPAYVFRYTRFFIDYdATKWLHEIKVPTLIIVGKDDKVTPVDESKLLNKLI--PNSRLIIIEDAGHLVLYEK-PSEL 266
Cdd:COG1647   155 YDRTPLRALAELQRLIRE-VRRDLPKITAPTLIIQSRKDEVVPPESARYIYERLgsPDKELVWLEDSGHVITLDKdREEV 233

                         250
                  ....*....|.
gi 1491196561 267 NGIIEEFIREL 277
Cdd:COG1647   234 AEEILDFLERL 244
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 5-275 5.00e-16

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 76.91  E-value: 5.00e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561   5 GKPFYIDVGNIKLNVYDSAEKcsyrEKLALIFLHGLPGQISNWKHQVEYFERKYRVIVYDQRGFGASDkpKKVSLNDyLQ 84
Cdd:PRK14875  109 PAPRKARIGGRTVRYLRLGEG----DGTPVVLIHGFGGDLNNWLFNHAALAAGRPVIALDLPGHGASS--KAVGAGS-LD 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561  85 DLDKIIESR--KLNTEDTILIGHSFGGMVAQAYTRTH--KVKGLVLIGSlTKIKPDIFDKITWYLPPIFWRKILykeTPL 160
Cdd:PRK14875  182 ELAAAVLAFldALGIERAHLVGHSMGGAVALRLAARApqRVASLTLIAP-AGLGPEINGDYIDGFVAAESRREL---KPV 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561 161 TRRLYRriffspsTPKEVFEEFIKDNKEY---------LERLPAYVFRYTRFFIDYDATkwLHEIKVPTLIIVGKDDKVT 231
Cdd:PRK14875  258 LELLFA-------DPALVTRQMVEDLLKYkrldgvddaLRALADALFAGGRQRVDLRDR--LASLAIPVLVIWGEQDRII 328

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1491196561 232 PVDESkllNKLIPNSRLIIIEDAGHLVLYEKPSELNGIIEEFIR 275
Cdd:PRK14875  329 PAAHA---QGLPDGVAVHVLPGAGHMPQMEAAADVNRLLAEFLG 369
PLN02894 PLN02894
hydrolase, alpha/beta fold family protein
 56-264 5.00e-14

hydrolase, alpha/beta fold family protein


Pssm-ID: 215484 [Multi-domain]  Cd Length: 402  Bit Score: 71.48  E-value: 5.00e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561  56 RKYRVIVYDQRGFGASDKPKKVSLNDYLQD---LDKIIESRKL-NTEDTILIGHSFGGMVAQAYTRTH--KVKGLVLIG- 128
Cdd:PLN02894  130 SRFRVIAIDQLGWGGSSRPDFTCKSTEETEawfIDSFEEWRKAkNLSNFILLGHSFGGYVAAKYALKHpeHVQHLILVGp 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561 129 ----SLTKIKPDIF--DKITW--YLPPIFWRKILykeTP-------------LTRRLYRRIFFSPSTPKEVFEEFIKDNK 187
Cdd:PLN02894  210 agfsSESDDKSEWLtkFRATWkgAVLNHLWESNF---TPqkiirglgpwgpnLVRRYTTARFGAHSTGDILSEEESKLLT 286

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561 188 EYLERLPA------YVFRYTRFFIDYDATKWL---HEIKVPTLIIVGKDDKVTPVDESKLLNKLIPNSRLIIIEDAGHLV 258
Cdd:PLN02894  287 DYVYHTLAakasgeLCLKYIFSFGAFARKPLLesaSEWKVPTTFIYGRHDWMNYEGAVEARKRMKVPCEIIRVPQGGHFV 366


                  ....*.
gi 1491196561 259 LYEKPS 264
Cdd:PLN02894  367 FLDNPS 372
PLN02824 PLN02824
hydrolase, alpha/beta fold family protein
 33-274 3.29e-13

hydrolase, alpha/beta fold family protein


Pssm-ID: 178419 [Multi-domain]  Cd Length: 294  Bit Score: 68.23  E-value: 3.29e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561  33 ALIFLHGLPGQISNWKHQVEYFERKYRVIVYDQRGFGASDKPKKVS---------------LNDYLQDLDKiiesrklnt 97
Cdd:PLN02824   31 ALVLVHGFGGNADHWRKNTPVLAKSHRVYAIDLLGYGYSDKPNPRSappnsfytfetwgeqLNDFCSDVVG--------- 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561  98 EDTILIGHSFGGMVA--QAYTRTHKVKGLVLIG-SLT--KIKpdifdKITWYLPP---IFWRkiLYKETPLTRRLYRRIf 169
Cdd:PLN02824  102 DPAFVICNSVGGVVGlqAAVDAPELVRGVMLINiSLRglHIK-----KQPWLGRPfikAFQN--LLRETAVGKAFFKSV- 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561 170 FSPSTPKEVFEEFIKDNKEYLERL------------PAYVFRYtrfFIDYDA----TKWLHEIKVPTLIIVGKDDKVTPV 233
Cdd:PLN02824  174 ATPETVKNILCQCYHDDSAVTDELveailrpglepgAVDVFLD---FISYSGgplpEELLPAVKCPVLIAWGEKDPWEPV 250

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1491196561 234 DESKLLNKLIPNSRLIIIEDAGHLVLYEKPSELNGIIEEFI 274
Cdd:PLN02824  251 ELGRAYANFDAVEDFIVLPGVGHCPQDEAPELVNPLIESFV 291
COG4757 COG4757
Predicted alpha/beta hydrolase [General function prediction only];
54-268 1.14e-11

Predicted alpha/beta hydrolase [General function prediction only];


Pssm-ID: 443790 [Multi-domain]  Cd Length: 289  Bit Score: 63.75  E-value: 1.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561  54 FERKYRVIVYDQRGFGASdKPK-----KVSLNDYL-QDLDKIIESRKLNTEDT--ILIGHSFGGMVAQAYTRTHKVKGLV 125
Cdd:COG4757    56 AERGFAVLTYDYRGIGLS-RPGslrgfDAGYRDWGeLDLPAVLDALRARFPGLplLLVGHSLGGQLLGLAPNAERVDRLV 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561 126 LIGSLTKIKPDiFDKITWYLPPIFWRKILyketPLTRRLY-----RRIFFSPSTPKEVFEEFIKdnkeyLERLPAYVFRY 200
Cdd:COG4757   135 TVASGSGYWRD-YPPRRRLKVLLFWHLLG----PLLTRLLgyfpgRRLGFGEDLPAGVARQWRR-----WCRRPRYFFDD 204

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1491196561 201 TRFfidyDATKWLHEIKVPTLIIVGKDDKVTPVDESKLLNKLIPNSRliiIEdagHLVLyeKPSELNG 268
Cdd:COG4757   205 DGE----DLEAALAAVTAPVLAISFTDDELAPPAAVDRLLAYYPNAP---VT---RRRL--APADLGL 260
PLN03084 PLN03084
alpha/beta hydrolase fold protein; Provisional
 34-270 1.88e-11

alpha/beta hydrolase fold protein; Provisional


Pssm-ID: 178633  Cd Length: 383  Bit Score: 63.75  E-value: 1.88e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561  34 LIFLHGLPGQISNWKHQVEYFERKYRVIVYDQRGFGASDKPK-----KVSLNDYLQDLDKIIESRKLNTEDTILIGHSFG 108
Cdd:PLN03084  130 VLLIHGFPSQAYSYRKVLPVLSKNYHAIAFDWLGFGFSDKPQpgygfNYTLDEYVSSLESLIDELKSDKVSLVVQGYFSP 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561 109 GMVAQAYTRTHKVKGLVLIGS-LTK----IKPDIFDKITWYLPPIFWRKIL------------YKETPLTRRLYRRIFFS 171
Cdd:PLN03084  210 PVVKYASAHPDKIKKLILLNPpLTKehakLPSTLSEFSNFLLGEIFSQDPLrasdkaltscgpYAMKEDDAMVYRRPYLT 289

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561 172 PSTP----KEVFEEFIKDNKEYLERLPAyvfrytrFFIDYDatkWlheiKVPTLIIVGKDDKVTPVDESKLLNKLIpNSR 247
Cdd:PLN03084  290 SGSSgfalNAISRSMKKELKKYIEEMRS-------ILTDKN---W----KTPITVCWGLRDRWLNYDGVEDFCKSS-QHK 354

                         250       260
                  ....*....|....*....|...
gi 1491196561 248 LIIIEDAGHLVLYEKPSELNGII 270
Cdd:PLN03084  355 LIELPMAGHHVQEDCGEELGGII 377
pro_imino_pep_1 TIGR01249
proline iminopeptidase, Neisseria-type subfamily; This model represents one of two related ...
 6-256 1.05e-10

proline iminopeptidase, Neisseria-type subfamily; This model represents one of two related families of proline iminopeptidase in the alpha/beta fold hydrolase family. The fine specificities of the various members, including both the range of short peptides from which proline can be removed and whether other amino acids such as alanine can be also removed, may vary among members.


Pssm-ID: 130316 [Multi-domain]  Cd Length: 306  Bit Score: 61.01  E-value: 1.05e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561   6 KPF---YIDVGNIKLNVYdsaEKCSYREKLALIFLHGLPGQISNWKHQVEYFERKYRVIVYDQRGFGASdKPKKVSLNDY 82
Cdd:TIGR01249   2 KPFvsgYLNVSDNHQLYY---EQSGNPDGKPVVFLHGGPGSGTDPGCRRFFDPETYRIVLFDQRGCGKS-TPHACLEENT 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561  83 LQDLDKIIES--RKLNTEDTILIGHSFGGMVAQAYTRTH--KVKGLVL---------------IGSLTKIKPDIFDKITW 143
Cdd:TIGR01249  78 TWDLVADIEKlrEKLGIKNWLVFGGSWGSTLALAYAQTHpeVVTGLVLrgifllrekewswfyEGGASMIYPDAWQRFMD 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561 144 YLPPIfwrkilYKETPLTRRLYRRIFFSPSTPKEVFEE------------FIKDN---------KEYLERLPAYVFRYTR 202
Cdd:TIGR01249 158 SIPEN------ERNEQLVNAYHDRLQSGDEETKLAAAKawvdwesttllrPINEIvstaedfkfSLAFARLENHYFVNKG 231

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1491196561 203 FF-----IDYDATKWLHeikVPTLIIVGKDDKVTPVDESKLLNKLIPNSRLIIIEDAGH 256
Cdd:TIGR01249 232 FLdvenfILDNISKIRN---IPTYIVHGRYDLCCPLQSAWALHKAFPEAELKVTNNAGH 287
PLN02679 PLN02679
hydrolase, alpha/beta fold family protein
 13-256 1.25e-10

hydrolase, alpha/beta fold family protein


Pssm-ID: 178283 [Multi-domain]  Cd Length: 360  Bit Score: 61.01  E-value: 1.25e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561  13 GNIKLNVYDSAEKCSYREKLALIFLHGLPGQISNWKHQVEYFERKYRVIVYDQRGFGASDKPKKVSLN-----DYLQD-L 86
Cdd:PLN02679   70 GEYSINYLVKGSPEVTSSGPPVLLVHGFGASIPHWRRNIGVLAKNYTVYAIDLLGFGASDKPPGFSYTmetwaELILDfL 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561  87 DKIIESrklnteDTILIGHSFGGM---VAQAYTRTHKVKGLVLI----GSLTKIkpdIFD--KITWYLPPIFWRKILYKE 157
Cdd:PLN02679  150 EEVVQK------PTVLIGNSVGSLacvIAASESTRDLVRGLVLLncagGMNNKA---VVDdwRIKLLLPLLWLIDFLLKQ 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561 158 TPLTRRLYRRIfFSPSTPKEVFEEfIKDNKEYLE-------RLPAYVFRYTRFFIDY-------DATKWLHEIKVPTLII 223
Cdd:PLN02679  221 RGIASALFNRV-KQRDNLKNILLS-VYGNKEAVDdelveiiRGPADDEGALDAFVSIvtgppgpNPIKLIPRISLPILVL 298

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1491196561 224 VGKDDKVTPVDE--SKLLNKL---IPNSRLIIIEDAGH 256
Cdd:PLN02679  299 WGDQDPFTPLDGpvGKYFSSLpsqLPNVTLYVLEGVGH 336
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 34-129 2.63e-08

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 50.98  E-value: 2.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561  34 LIFLHGLPGQISNWKHQVEYFERK-YRVIVYDqrgFGASDKPKKVS---LNDYLQDLDKIIESRKLNtedtiLIGHSFGG 109
Cdd:COG1075     8 VVLVHGLGGSAASWAPLAPRLRAAgYPVYALN---YPSTNGSIEDSaeqLAAFVDAVLAATGAEKVD-----LVGHSMGG 79

                          90       100
                  ....*....|....*....|....
gi 1491196561 110 MVAQAYTRTH----KVKGLVLIGS 129
Cdd:COG1075    80 LVARYYLKRLggaaKVARVVTLGT 103
PLN02578 PLN02578
hydrolase
 30-274 4.37e-08

hydrolase


Pssm-ID: 215315 [Multi-domain]  Cd Length: 354  Bit Score: 53.31  E-value: 4.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561  30 EKLALIFLHGLPGQISNWKHQVEYFERKYRVIVYDQRGFGASDKpkkvSLNDYLQDL--DKIIE-SRKLNTEDTILIGHS 106
Cdd:PLN02578   85 EGLPIVLIHGFGASAFHWRYNIPELAKKYKVYALDLLGFGWSDK----ALIEYDAMVwrDQVADfVKEVVKEPAVLVGNS 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561 107 FGGMVA--QAYTRTHKVKGLVLIGSLTKIKPDIFDKItwylppifwRKILYKETPLTRRL-------YRR--IFF----- 170
Cdd:PLN02578  161 LGGFTAlsTAVGYPELVAGVALLNSAGQFGSESREKE---------EAIVVEETVLTRFVvkplkewFQRvvLGFlfwqa 231

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561 171 -SPSTPKEVFEEFIKDNK---EYLER---LPA--------YVFRYTRFFI---DYDATKWLHEIKVPTLIIVGKDDKVTP 232
Cdd:PLN02578  232 kQPSRIESVLKSVYKDKSnvdDYLVEsitEPAadpnagevYYRLMSRFLFnqsRYTLDSLLSKLSCPLLLLWGDLDPWVG 311

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1491196561 233 VDESKLLNKLIPNSRLIIIEdAGHLVLYEKPSELNGIIEEFI 274
Cdd:PLN02578  312 PAKAEKIKAFYPDTTLVNLQ-AGHCPHDEVPEQVNKALLEWL 352
PRK05855 PRK05855
SDR family oxidoreductase;
33-274 5.13e-08

SDR family oxidoreductase;


Pssm-ID: 235628 [Multi-domain]  Cd Length: 582  Bit Score: 53.45  E-value: 5.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561  33 ALIFLHGLPGQISNWKHQVEYFERKYRVIVYDQRGFGASDKPKKVS---LNDYLQDLDKIIES----RKLNtedtiLIGH 105
Cdd:PRK05855   27 TVVLVHGYPDNHEVWDGVAPLLADRFRVVAYDVRGAGRSSAPKRTAaytLARLADDFAAVIDAvspdRPVH-----LLAH 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561 106 SFGGMVAQAYTRTHKVKGLV-----------------LIGSLTKIKPDIFDKI------TWY--------LPPIFWRKIL 154
Cdd:PRK05855  102 DWGSIQGWEAVTRPRAAGRIasftsvsgpsldhvgfwLRSGLRRPTPRRLARAlgqllrSWYiylfhlpvLPELLWRLGL 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561 155 YKETPLTRRLYRRIFFSPSTPKEVFEEFIKDNKEYlerlPAYVFRytRFFIDYDatkwlHEIKVPTLIIVGKDDK-VTPv 233
Cdd:PRK05855  182 GRAWPRLLRRVEGTPVDPIPTQTTLSDGAHGVKLY----RANMIR--SLSRPRE-----RYTDVPVQLIVPTGDPyVRP- 249

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1491196561 234 desKLLNKLIP-NSRLIIIE-DAGHLVLYEKPSELNGIIEEFI 274
Cdd:PRK05855  250 ---ALYDDLSRwVPRLWRREiKAGHWLPMSHPQVLAAAVAEFV 289
PRK03592 PRK03592
haloalkane dehalogenase; Provisional
 17-277 4.01e-07

haloalkane dehalogenase; Provisional


Pssm-ID: 235135  Cd Length: 295  Bit Score: 50.38  E-value: 4.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561  17 LNVYDSaeKCSYREK---LALIFLHGLPGQISNWKHQVEYFERKYRVIVYDQRGFGASDKPK-KVSLNDYLQDLDKIIES 92
Cdd:PRK03592   12 VEVLGS--RMAYIETgegDPIVFLHGNPTSSYLWRNIIPHLAGLGRCLAPDLIGMGASDKPDiDYTFADHARYLDAWFDA 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561  93 RKLntEDTILIGHSFGGMVAQAYTRTH--KVKGLVLigsltkikpdiFDKItwyLPPIFWRKIlykeTPLTRRLYRRIff 170
Cdd:PRK03592   90 LGL--DDVVLVGHDWGSALGFDWAARHpdRVRGIAF-----------MEAI---VRPMTWDDF----PPAVRELFQAL-- 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561 171 spSTPkEVFEEFIKDNKEYLER-LPAYVFR---------YTRFFI-----------------------------DYDAtk 211
Cdd:PRK03592  148 --RSP-GEGEEMVLEENVFIERvLPGSILRplsdeemavYRRPFPtpesrrptlswprelpidgepadvvalveEYAQ-- 222

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1491196561 212 WLHEIKVPTLIIVGKDDKVTPVDES-KLLNKLIPNSRLIIIEDAGHLVLYEKPSELNGIIEEFIREL 277
Cdd:PRK03592  223 WLATSDVPKLLINAEPGAILTTGAIrDWCRSWPNQLEITVFGAGLHFAQEDSPEEIGAAIAAWLRRL 289
PRK10673 PRK10673
esterase;
31-127 1.19e-05

esterase;


Pssm-ID: 182637 [Multi-domain]  Cd Length: 255  Bit Score: 45.49  E-value: 1.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561  31 KLALIFLHGLPGQISNWKHQVEYFERKYRVIVYDQRGFGASDKPKKVSLNDYLQDLDKIIESrkLNTEDTILIGHSFGGM 110
Cdd:PRK10673   16 NSPIVLVHGLFGSLDNLGVLARDLVNDHDIIQVDMRNHGLSPRDPVMNYPAMAQDLLDTLDA--LQIEKATFIGHSMGGK 93

                          90
                  ....*....|....*....
gi 1491196561 111 VAQAYTR--THKVKGLVLI 127
Cdd:PRK10673   94 AVMALTAlaPDRIDKLVAI 112
COG2945 COG2945
Alpha/beta superfamily hydrolase [General function prediction only];
93-275 1.19e-05

Alpha/beta superfamily hydrolase [General function prediction only];


Pssm-ID: 442188 [Multi-domain]  Cd Length: 201  Bit Score: 45.15  E-value: 1.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561  93 RKLNTEDTILIGHSFGGMVA-QAYTRTHKVKGLVLIGsltkikpdifdkitwylPPifwrkilyketpltrrlyrriffs 171
Cdd:COG2945    91 RAQNPLPLWLAGFSFGAYVAlQLAMRLPEVEGLILVA-----------------PP------------------------ 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561 172 pstpkevfeefikdnkeylerlpayVFRYtrffiDYDAtkwLHEIKVPTLIIVGKDDKVTPVDES-KLLNKLIPNSRLII 250
Cdd:COG2945   130 -------------------------VNRY-----DFSF---LAPCPAPTLVIHGEQDEVVPPAEVlDWARPLSPPLPVVV 176

                         170       180
                  ....*....|....*....|....*
gi 1491196561 251 IEDAGHLvLYEKPSELNGIIEEFIR 275
Cdd:COG2945   177 VPGADHF-FHGKLDELKELVARYLP 200
PRK11126 PRK11126
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; Provisional
 34-128 5.55e-05

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; Provisional


Pssm-ID: 236855 [Multi-domain]  Cd Length: 242  Bit Score: 43.29  E-value: 5.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561  34 LIFLHGLPGQISNWKHQVEYFeRKYRVIVYDQRGFGASdkpKKVSLNDYLQDLDKIIES-RKLNTEDTILIGHSFGG--- 109
Cdd:PRK11126    5 LVFLHGLLGSGQDWQPVGEAL-PDYPRLYIDLPGHGGS---AAISVDGFADVSRLLSQTlQSYNILPYWLVGYSLGGria 80

                          90
                  ....*....|....*....
gi 1491196561 110 MVAQAYTRTHKVKGLVLIG 128
Cdd:PRK11126   81 MYYACQGLAGGLCGLIVEG 99
PRK03204 PRK03204
haloalkane dehalogenase; Provisional
 34-170 9.07e-05

haloalkane dehalogenase; Provisional


Pssm-ID: 179554 [Multi-domain]  Cd Length: 286  Bit Score: 42.92  E-value: 9.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561  34 LIFLHGLPGQISNWKHQVEYFERKYRVIVYDQRGFGASDKPKKV--SLNDYLQDLDKIIESrkLNTEDTILIGHSFGGMV 111
Cdd:PRK03204   37 ILLCHGNPTWSFLYRDIIVALRDRFRCVAPDYLGFGLSERPSGFgyQIDEHARVIGEFVDH--LGLDRYLSMGQDWGGPI 114

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1491196561 112 --AQAYTRTHKVKGLVLiGSltkikpdifdkiTWYLP------PIFWRkiLYKETPLTRRLYRRIFF 170
Cdd:PRK03204  115 smAVAVERADRVRGVVL-GN------------TWFWPadtlamKAFSR--VMSSPPVQYAILRRNFF 166
FSH1 pfam03959
Serine hydrolase (FSH1); This is a family of serine hydrolases.
 202-258 2.59e-04

Serine hydrolase (FSH1); This is a family of serine hydrolases.


Pssm-ID: 461110  Cd Length: 208  Bit Score: 41.11  E-value: 2.59e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1491196561 202 RFFI----------DYDATKWLHEIKVPTLIIVGKDDKVTPVDESKLLNKLIPNSRLIIIEDAGHLV 258
Cdd:pfam03959 133 KFAIlfsgfrprppIYQEYYSEDPIQTPSLHVIGELDTVVPEERSEKLAEACKNSPTVLEHPGGHFV 199
YdeN COG3545
Predicted esterase of the alpha/beta hydrolase fold [General function prediction only];
35-257 8.74e-04

Predicted esterase of the alpha/beta hydrolase fold [General function prediction only];


Pssm-ID: 442766 [Multi-domain]  Cd Length: 170  Bit Score: 39.06  E-value: 8.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561  35 IFLHGLPG------QiSNWKHQVEyferkyRVIVYDQRGfgaSDKPkkvSLNDYLQDLDKIIESRklnTEDTILIGHSFG 108
Cdd:COG3545     1 LIVPGLGGsgpdhwQ-SWWERELP------TVRRVEQPD---WDRP---DLDDWLAALDAAVAAA---DGPVVLVAHSLG 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561 109 GM--VAQAYTRTHKVKGLVLIGSltkikpdifdkitwylppifwrkilyketpltrrlyrrifFSPSTPKEVFEEFIKDN 186
Cdd:COG3545    65 CLavAHWAARLPRKVAGALLVAP----------------------------------------PDPERPGFLPELDAGFA 104

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1491196561 187 KEYLERLPayvfrytrffidydatkwlheikVPTLIIVGKDDKVTPVDESKLL-NKLipNSRLIIIEDAGHL 257
Cdd:COG3545   105 PIPRAPLP-----------------------FPSIVVASRNDPYVSFERAERLaRAW--GAELIDLGAAGHI 151
YpfH COG0400
Predicted esterase [General function prediction only];
29-127 8.80e-03

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 36.42  E-value: 8.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491196561  29 REKLALIFLHG---LPGQISNWkhqveyFERKYRVIVYDQRGFGASDkpkkvslnDYLQD-LDKIIESRKLNTEDTILIG 104
Cdd:COG0400    30 LPGAAVLAPRApvpEGPGGRAW------FDLSFLEGREDEEGLAAAA--------EALAAfIDELEARYGIDPERIVLAG 95

                          90       100
                  ....*....|....*....|....*
gi 1491196561 105 HSFGGMVAQAYTRTH--KVKGLVLI 127
Cdd:COG0400    96 FSQGAAMALSLALRRpeLLAGVVAL 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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