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Conserved domains on  [gi|1491109166|gb|RLG01870|]
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hypothetical protein DRN58_00765, partial [Thermococci archaeon]

Protein Classification

lysylphosphatidylglycerol synthase transmembrane domain-containing protein( domain architecture ID 2809)

lysylphosphatidylglycerol synthase transmembrane domain-containing protein similar to Escherichia coli inner membrane protein YbhN contains the seven TM-segment transmembrane domain of bacterial phosphatidylglycerol lysyltransferases, whose function is to add lysyl groups to membrane lipids

Gene Ontology:  GO:0016020

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIGR00374 super family cl04219
conserved hypothetical protein; This model is built on a superfamily of proteins in the ...
 27-135 5.21e-19

conserved hypothetical protein; This model is built on a superfamily of proteins in the Archaea and in Aquifex aeolicus. The authenticity of homology can be seen in the presence of motifs in the alignment that include residues relatively rare among these sequences, even though the alignment includes long regions of low-complexity hydrophobic sequences. One apparent fusion protein contains a Glycos_transf_2 region in the N-terminal half of the protein and a region homologous to this superfamily in the C-terminal region. [Unknown function, General]


The actual alignment was detected with superfamily member TIGR00374:

Pssm-ID: 470976  Cd Length: 319  Bit Score: 80.50  E-value: 5.21e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491109166  27 GIQETLEVLKNIKLPFLLLGIFIELFLFGLWGYRWKIILEAAKEKISIKNLYLSLFIGVLVNNITPAAkAGGEPLRAYIL 106
Cdd:TIGR00374  16 GPGEILRALGNANPFYLLLAFLLQFLVLALWTLRWKLISNALGIKYSFRHLFMLLFVGMFINNITPSA-AGGEPMRAYML 94

                          90       100
                  ....*....|....*....|....*....
gi 1491109166 107 SRMDNIKSEKAFATITADRVFDSFPYVFL 135
Cdd:TIGR00374  95 KKKEGISASLGFSTVLAERVFDLVIFILL 123
 
Name Accession Description Interval E-value
TIGR00374 TIGR00374
conserved hypothetical protein; This model is built on a superfamily of proteins in the ...
 27-135 5.21e-19

conserved hypothetical protein; This model is built on a superfamily of proteins in the Archaea and in Aquifex aeolicus. The authenticity of homology can be seen in the presence of motifs in the alignment that include residues relatively rare among these sequences, even though the alignment includes long regions of low-complexity hydrophobic sequences. One apparent fusion protein contains a Glycos_transf_2 region in the N-terminal half of the protein and a region homologous to this superfamily in the C-terminal region. [Unknown function, General]


Pssm-ID: 129470  Cd Length: 319  Bit Score: 80.50  E-value: 5.21e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491109166  27 GIQETLEVLKNIKLPFLLLGIFIELFLFGLWGYRWKIILEAAKEKISIKNLYLSLFIGVLVNNITPAAkAGGEPLRAYIL 106
Cdd:TIGR00374  16 GPGEILRALGNANPFYLLLAFLLQFLVLALWTLRWKLISNALGIKYSFRHLFMLLFVGMFINNITPSA-AGGEPMRAYML 94

                          90       100
                  ....*....|....*....|....*....
gi 1491109166 107 SRMDNIKSEKAFATITADRVFDSFPYVFL 135
Cdd:TIGR00374  95 KKKEGISASLGFSTVLAERVFDLVIFILL 123
LPG_synthase_TM pfam03706
Lysylphosphatidylglycerol synthase TM region; LPG_synthase_TM is the N-terminal region of this ...
 27-135 3.69e-18

Lysylphosphatidylglycerol synthase TM region; LPG_synthase_TM is the N-terminal region of this family of bacterial phosphatidylglycerol lysyltransferases. The function of the family is to add lysyl groups to membrane lipids, and this region is the transmembrane domain of 7xTMs. In order to counteract attack by membrane-damaging external cationic antimicrobial molecules - from host immune systems, bacteriocins, defensins, etc - bacteria modify their anionic membrane phosphatidylglycerol with positively-charged L-lysine; this results in repulsion of the foreign cationic peptides.


Pssm-ID: 461018  Cd Length: 302  Bit Score: 78.18  E-value: 3.69e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491109166  27 GIQETLEVLKNIKLPFLLLGIFIELFLFGLWGYRWKIILEAAKEKISIKNLYLSLFIGVLVNNITPAAkAGGEPLRAYIL 106
Cdd:pfam03706  20 DLSELAELLRSADPGWLLLALLLALLSLLLRALRWRLLLRALGARISFRRAFRAYLIGYFANNVTPGR-LGGEVVRAYLL 98

                          90       100
                  ....*....|....*....|....*....
gi 1491109166 107 SRMDNIKSEKAFATITADRVFDSFPYVFL 135
Cdd:pfam03706  99 KRREGLSLSKALASVVLERLLDLLTLLLL 127
AglD2 COG0392
Predicted membrane flippase AglD2/YbhN, UPF0104 family [Cell wall/membrane/envelope biogenesis] ...
 35-135 4.55e-16

Predicted membrane flippase AglD2/YbhN, UPF0104 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440161  Cd Length: 289  Bit Score: 72.29  E-value: 4.55e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491109166  35 LKNIKLPFLLLGIFIELFLFGLWGYRWKIILEAAKEKISIKNLYLSLFIGVLVNNITPAAkAGGEPLRAYILSRmDNIKS 114
Cdd:COG0392     1 LRAANPWWLLLALLLTLLSYLLLALRWRLLLRALGVKLPFRRLFLVSFIGYFGNNIGPGA-LGGEAVRARLLSR-RGVPA 78

                          90       100
                  ....*....|....*....|.
gi 1491109166 115 EKAFATITADRVFDSFPYVFL 135
Cdd:COG0392    79 GKAAAIVALERLTDLLGLLLL 99
 
Name Accession Description Interval E-value
TIGR00374 TIGR00374
conserved hypothetical protein; This model is built on a superfamily of proteins in the ...
 27-135 5.21e-19

conserved hypothetical protein; This model is built on a superfamily of proteins in the Archaea and in Aquifex aeolicus. The authenticity of homology can be seen in the presence of motifs in the alignment that include residues relatively rare among these sequences, even though the alignment includes long regions of low-complexity hydrophobic sequences. One apparent fusion protein contains a Glycos_transf_2 region in the N-terminal half of the protein and a region homologous to this superfamily in the C-terminal region. [Unknown function, General]


Pssm-ID: 129470  Cd Length: 319  Bit Score: 80.50  E-value: 5.21e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491109166  27 GIQETLEVLKNIKLPFLLLGIFIELFLFGLWGYRWKIILEAAKEKISIKNLYLSLFIGVLVNNITPAAkAGGEPLRAYIL 106
Cdd:TIGR00374  16 GPGEILRALGNANPFYLLLAFLLQFLVLALWTLRWKLISNALGIKYSFRHLFMLLFVGMFINNITPSA-AGGEPMRAYML 94

                          90       100
                  ....*....|....*....|....*....
gi 1491109166 107 SRMDNIKSEKAFATITADRVFDSFPYVFL 135
Cdd:TIGR00374  95 KKKEGISASLGFSTVLAERVFDLVIFILL 123
LPG_synthase_TM pfam03706
Lysylphosphatidylglycerol synthase TM region; LPG_synthase_TM is the N-terminal region of this ...
 27-135 3.69e-18

Lysylphosphatidylglycerol synthase TM region; LPG_synthase_TM is the N-terminal region of this family of bacterial phosphatidylglycerol lysyltransferases. The function of the family is to add lysyl groups to membrane lipids, and this region is the transmembrane domain of 7xTMs. In order to counteract attack by membrane-damaging external cationic antimicrobial molecules - from host immune systems, bacteriocins, defensins, etc - bacteria modify their anionic membrane phosphatidylglycerol with positively-charged L-lysine; this results in repulsion of the foreign cationic peptides.


Pssm-ID: 461018  Cd Length: 302  Bit Score: 78.18  E-value: 3.69e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491109166  27 GIQETLEVLKNIKLPFLLLGIFIELFLFGLWGYRWKIILEAAKEKISIKNLYLSLFIGVLVNNITPAAkAGGEPLRAYIL 106
Cdd:pfam03706  20 DLSELAELLRSADPGWLLLALLLALLSLLLRALRWRLLLRALGARISFRRAFRAYLIGYFANNVTPGR-LGGEVVRAYLL 98

                          90       100
                  ....*....|....*....|....*....
gi 1491109166 107 SRMDNIKSEKAFATITADRVFDSFPYVFL 135
Cdd:pfam03706  99 KRREGLSLSKALASVVLERLLDLLTLLLL 127
AglD2 COG0392
Predicted membrane flippase AglD2/YbhN, UPF0104 family [Cell wall/membrane/envelope biogenesis] ...
 35-135 4.55e-16

Predicted membrane flippase AglD2/YbhN, UPF0104 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440161  Cd Length: 289  Bit Score: 72.29  E-value: 4.55e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491109166  35 LKNIKLPFLLLGIFIELFLFGLWGYRWKIILEAAKEKISIKNLYLSLFIGVLVNNITPAAkAGGEPLRAYILSRmDNIKS 114
Cdd:COG0392     1 LRAANPWWLLLALLLTLLSYLLLALRWRLLLRALGVKLPFRRLFLVSFIGYFGNNIGPGA-LGGEAVRARLLSR-RGVPA 78

                          90       100
                  ....*....|....*....|.
gi 1491109166 115 EKAFATITADRVFDSFPYVFL 135
Cdd:COG0392    79 GKAAAIVALERLTDLLGLLLL 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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